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https://www.readbyqxmd.com/read/29226812/the-right-diet-for-heart-failure-finding-morsels-for-success
#1
EDITORIAL
Sumeet S Mitter, Rajesh Vedanthan, Valentin Fuster
No abstract text is available yet for this article.
November 27, 2017: JACC. Heart Failure
https://www.readbyqxmd.com/read/29217712/cantos-a-gigantic-proof-of-concept-trial
#2
Borja Ibañez, Valentin Fuster
No abstract text is available yet for this article.
December 8, 2017: Circulation Research
https://www.readbyqxmd.com/read/29217711/cardiovascular-research-center-at-icahn-school-of-medicine-at-mount-sinai-translational-mission
#3
Roger J Hajjar, Kiyotake Ishikawa, Jason C Kovacic, Valentin Fuster
No abstract text is available yet for this article.
December 8, 2017: Circulation Research
https://www.readbyqxmd.com/read/29216983/atrial-infarction-and-ischemic-mitral-regurgitation-contribute-to-post-mi-remodeling-of-the-left-atrium
#4
Jaume Aguero, Carlos Galan-Arriola, Rodrigo Fernandez-Jimenez, Javier Sanchez-Gonzalez, Nina Ajmone, Victoria Delgado, Jorge Solis, Gonzalo J Lopez, Antonio de Molina-Iracheta, Roger J Hajjar, Jeroen J Bax, Valentin Fuster, Borja Ibáñez
BACKGROUND: Left atrial (LA) remodeling after an acute myocardial infarction (MI) is poorly characterized regarding its determinants or its effect on ischemic mitral regurgitation (MR) development. OBJECTIVES: The purpose of this study was: 1) to compare LA structural remodeling in experimental MI swine models recapitulating the effects of left ventricular (LV) dysfunction, ischemic MR, and left atrial infarction (LAI); and 2) to analyze how LA remodeling influences ischemic MR development...
December 12, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29198877/the-future-role-of-the-united-states-in-global-health-emphasis-on-cardiovascular-disease
#5
REVIEW
Valentin Fuster, Jendayi Frazer, Megan Snair, Rajesh Vedanthan, Victor Dzau
U.S. global health investment has focused on detection, treatment, and eradication of infectious diseases such as tuberculosis, malaria, and human immunodeficiency virus/acquired immunodeficiency syndrome, with significant results. Although efforts should be maintained and expanded to provide ongoing therapy for chronic infectious disease, there is a pressing need to meet the challenge of noncommunicable diseases, which constitute the highest burden of diseases globally. A Committee of the National Academies of Sciences, Engineering, and Medicine has made 14 recommendations that require ongoing commitments to eradication of infectious disease and increase the emphasis on chronic diseases such as cardiovascular disease...
November 23, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29168477/prevention-saving-lives-the-importance-of-having-resolve
#6
Rajesh Vedanthan, Valentin Fuster
No abstract text is available yet for this article.
November 23, 2017: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/29157982/who-truly-benefits-from-pre-publishing-and-rushing-publishing-not-patients-nor-clinicians
#7
EDITORIAL
Valentin Fuster
No abstract text is available yet for this article.
November 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29155386/one-year-clinical-outcome-of-early-administration-of-intravenous-beta-blockers-in-patients-with-st-segment-elevation-myocardial-infarction-before-primary-percutaneous-coronary-reperfusion-one-year-results-from-the-early-bami-trial
#8
Vincent Roolvink, Jan Paul Ottervanger, Borja Ibáñez, Jan Henk Dambrink, Marcel Gosselink, Elvin Kedhi, Niels van Royen, Erik Lipsic, Wouter Remkes, Jan Piek, Valentin Fuster, Arnoud van 't Hof
AIMS: The EARLY-BAMI (Early intravenous beta-blockers in patients with ST-segment elevation myocardial infarction before PPCI) trial included 684 STEMI patients to iv metoprolol (2 x 5 mg bolus) or matched placebo before PPCI. One year clinical outcome was defined by major cardiac adverse event (MACE) rate, defined as cardiac death, nonfatal reinfarction, or target vessel revascularization. METHODS AND RESULTS: One year follow up was obtained in 629 patients (92%)...
November 21, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29145946/predicting-subclinical-atherosclerosis-in-low-risk%C3%A2-individuals-ideal-cardiovascular-health-score-and-fuster-bewat-score
#9
Juan Miguel Fernández-Alvira, Valentín Fuster, Stuart Pocock, Javier Sanz, Leticia Fernández-Friera, Martín Laclaustra, Rodrigo Fernández-Jiménez, José Mendiguren, Antonio Fernández-Ortiz, Borja Ibáñez, Héctor Bueno
BACKGROUND: The ideal cardiovascular health score (ICHS) is recommended for use in primary prevention. Simpler tools not requiring laboratory tests, such as the Fuster-BEWAT (blood pressure [B], exercise [E], weight [W], alimentation [A], and tobacco [T]) score (FBS), are also available. OBJECTIVES: The purpose of this study was to compare the effectiveness of ICHS and FBS in predicting the presence and extent of subclinical atherosclerosis. METHODS: A total of 3,983 participants 40 to 54 years of age were enrolled in the PESA (Progression of Early Subclinical Atherosclerosis) cohort...
November 14, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29083408/exome-wide-association-study-of-plasma-lipids-in-300-000-individuals
#10
Dajiang J Liu, Gina M Peloso, Haojie Yu, Adam S Butterworth, Xiao Wang, Anubha Mahajan, Danish Saleheen, Connor Emdin, Dewan Alam, Alexessander Couto Alves, Philippe Amouyel, Emanuele Di Angelantonio, Dominique Arveiler, Themistocles L Assimes, Paul L Auer, Usman Baber, Christie M Ballantyne, Lia E Bang, Marianne Benn, Joshua C Bis, Michael Boehnke, Eric Boerwinkle, Jette Bork-Jensen, Erwin P Bottinger, Ivan Brandslund, Morris Brown, Fabio Busonero, Mark J Caulfield, John C Chambers, Daniel I Chasman, Y Eugene Chen, Yii-Der Ida Chen, Rajiv Chowdhury, Cramer Christensen, Audrey Y Chu, John M Connell, Francesco Cucca, L Adrienne Cupples, Scott M Damrauer, Gail Davies, Ian J Deary, George Dedoussis, Joshua C Denny, Anna Dominiczak, Marie-Pierre Dubé, Tapani Ebeling, Gudny Eiriksdottir, Tõnu Esko, Aliki-Eleni Farmaki, Mary F Feitosa, Marco Ferrario, Jean Ferrieres, Ian Ford, Myriam Fornage, Paul W Franks, Timothy M Frayling, Ruth Frikke-Schmidt, Lars G Fritsche, Philippe Frossard, Valentin Fuster, Santhi K Ganesh, Wei Gao, Melissa E Garcia, Christian Gieger, Franco Giulianini, Mark O Goodarzi, Harald Grallert, Niels Grarup, Leif Groop, Megan L Grove, Vilmundur Gudnason, Torben Hansen, Tamara B Harris, Caroline Hayward, Joel N Hirschhorn, Oddgeir L Holmen, Jennifer Huffman, Yong Huo, Kristian Hveem, Sehrish Jabeen, Anne U Jackson, Johanna Jakobsdottir, Marjo-Riitta Jarvelin, Gorm B Jensen, Marit E Jørgensen, J Wouter Jukema, Johanne M Justesen, Pia R Kamstrup, Stavroula Kanoni, Fredrik Karpe, Frank Kee, Amit V Khera, Derek Klarin, Heikki A Koistinen, Jaspal S Kooner, Charles Kooperberg, Kari Kuulasmaa, Johanna Kuusisto, Markku Laakso, Timo Lakka, Claudia Langenberg, Anne Langsted, Lenore J Launer, Torsten Lauritzen, David C M Liewald, Li An Lin, Allan Linneberg, Ruth J F Loos, Yingchang Lu, Xiangfeng Lu, Reedik Mägi, Anders Malarstig, Ani Manichaikul, Alisa K Manning, Pekka Mäntyselkä, Eirini Marouli, Nicholas G D Masca, Andrea Maschio, James B Meigs, Olle Melander, Andres Metspalu, Andrew P Morris, Alanna C Morrison, Antonella Mulas, Martina Müller-Nurasyid, Patricia B Munroe, Matt J Neville, Jonas B Nielsen, Sune F Nielsen, Børge G Nordestgaard, Jose M Ordovas, Roxana Mehran, Christoper J O'Donnell, Marju Orho-Melander, Cliona M Molony, Pieter Muntendam, Sandosh Padmanabhan, Colin N A Palmer, Dorota Pasko, Aniruddh P Patel, Oluf Pedersen, Markus Perola, Annette Peters, Charlotta Pisinger, Giorgio Pistis, Ozren Polasek, Neil Poulter, Bruce M Psaty, Daniel J Rader, Asif Rasheed, Rainer Rauramaa, Dermot F Reilly, Alex P Reiner, Frida Renström, Stephen S Rich, Paul M Ridker, John D Rioux, Neil R Robertson, Dan M Roden, Jerome I Rotter, Igor Rudan, Veikko Salomaa, Nilesh J Samani, Serena Sanna, Naveed Sattar, Ellen M Schmidt, Robert A Scott, Peter Sever, Raquel S Sevilla, Christian M Shaffer, Xueling Sim, Suthesh Sivapalaratnam, Kerrin S Small, Albert V Smith, Blair H Smith, Sangeetha Somayajula, Lorraine Southam, Timothy D Spector, Elizabeth K Speliotes, John M Starr, Kathleen E Stirrups, Nathan Stitziel, Konstantin Strauch, Heather M Stringham, Praveen Surendran, Hayato Tada, Alan R Tall, Hua Tang, Jean-Claude Tardif, Kent D Taylor, Stella Trompet, Philip S Tsao, Jaakko Tuomilehto, Anne Tybjaerg-Hansen, Natalie R van Zuydam, Anette Varbo, Tibor V Varga, Jarmo Virtamo, Melanie Waldenberger, Nan Wang, Nick J Wareham, Helen R Warren, Peter E Weeke, Joshua Weinstock, Jennifer Wessel, James G Wilson, Peter W F Wilson, Ming Xu, Hanieh Yaghootkar, Robin Young, Eleftheria Zeggini, He Zhang, Neil S Zheng, Weihua Zhang, Yan Zhang, Wei Zhou, Yanhua Zhou, Magdalena Zoledziewska, Joanna M M Howson, John Danesh, Mark I McCarthy, Chad A Cowan, Goncalo Abecasis, Panos Deloukas, Kiran Musunuru, Cristen J Willer, Sekar Kathiresan
We screened variants on an exome-focused genotyping array in >300,000 participants (replication in >280,000 participants) and identified 444 independent variants in 250 loci significantly associated with total cholesterol (TC), high-density-lipoprotein cholesterol (HDL-C), low-density-lipoprotein cholesterol (LDL-C), and/or triglycerides (TG). At two loci (JAK2 and A1CF), experimental analysis in mice showed lipid changes consistent with the human data. We also found that: (i) beta-thalassemia trait carriers displayed lower TC and were protected from coronary artery disease (CAD); (ii) excluding the CETP locus, there was not a predictable relationship between plasma HDL-C and risk for age-related macular degeneration; (iii) only some mechanisms of lowering LDL-C appeared to increase risk for type 2 diabetes (T2D); and (iv) TG-lowering alleles involved in hepatic production of TG-rich lipoproteins (TM6SF2 and PNPLA3) tracked with higher liver fat, higher risk for T2D, and lower risk for CAD, whereas TG-lowering alleles involved in peripheral lipolysis (LPL and ANGPTL4) had no effect on liver fat but decreased risks for both T2D and CAD...
October 30, 2017: Nature Genetics
https://www.readbyqxmd.com/read/29059296/carotid-plaque-thickness-and-carotid-plaque-burden-predict-future-cardiovascular-events-in-asymptomatic-adult-americans
#11
Henrik Sillesen, Samantha Sartori, Benjamin Sandholt, Usman Baber, Roxana Mehran, Valentin Fuster
Introduction: Prediction of cardiovascular events improves using imaging, i.e. coronary calcium score and ultrasound assessment of carotid plaque. This study analysed the predictive value of two ultrasound measures of carotid plaque size: carotid plaque thickness and carotid and intima-media thickness (IMT). Methods and results: A total of 6102 asymptomatic persons underwent assessment of conventional risk factors and imaging by carotid ultrasound. Carotid plaque burden (cPB) and maximum carotid plaque thickness (cPTmax) were measured from 'cross-sectional sweep' video acquisition of the carotid artery...
October 20, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/29056410/the-lancet-commission-on-pollution-and-health
#12
REVIEW
Philip J Landrigan, Richard Fuller, Nereus J R Acosta, Olusoji Adeyi, Robert Arnold, Niladri Nil Basu, Abdoulaye Bibi Baldé, Roberto Bertollini, Stephan Bose-O'Reilly, Jo Ivey Boufford, Patrick N Breysse, Thomas Chiles, Chulabhorn Mahidol, Awa M Coll-Seck, Maureen L Cropper, Julius Fobil, Valentin Fuster, Michael Greenstone, Andy Haines, David Hanrahan, David Hunter, Mukesh Khare, Alan Krupnick, Bruce Lanphear, Bindu Lohani, Keith Martin, Karen V Mathiasen, Maureen A McTeer, Christopher J L Murray, Johanita D Ndahimananjara, Frederica Perera, Janez Potočnik, Alexander S Preker, Jairam Ramesh, Johan Rockström, Carlos Salinas, Leona D Samson, Karti Sandilya, Peter D Sly, Kirk R Smith, Achim Steiner, Richard B Stewart, William A Suk, Onno C P van Schayck, Gautam N Yadama, Kandeh Yumkella, Ma Zhong
No abstract text is available yet for this article.
October 19, 2017: Lancet
https://www.readbyqxmd.com/read/29050566/how-low-to-go-with-glucose-cholesterol-%C3%A2-and-blood-pressure-in-primary%C3%A2-prevention-of-cvd
#13
REVIEW
Kimberly N Hong, Valentin Fuster, Robert S Rosenson, Clive Rosendorff, Deepak L Bhatt
Diabetes, hyperlipidemia, and hypertension are modifiable risk factors that predict cardiovascular disease events. The effect of these risk factors on incident cardiovascular disease increases with progressively higher levels of glucose, low-density lipoprotein cholesterol, and blood pressure. The thresholds for initiating treatment of these modifiable risk factors and the optimal goals of risk factor modification are a focus of primary prevention research. Although an aggressive approach is appealing, adverse events may occur, and potential physiological barriers may exist...
October 24, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29025757/current-state-of-basic-and-translational-cardiovascular-research-in-spain
#14
Enrique Lara-Pezzi, Vicente Andrés, Francisco Fernández-Avilés, Valentín Fuster, Borja Ibáñez
No abstract text is available yet for this article.
October 13, 2017: Circulation Research
https://www.readbyqxmd.com/read/29025561/arterial-thrombus-stability-does-it-matter-and-can-we-detect-it
#15
REVIEW
Diana A Gorog, Zahi A Fayad, Valentin Fuster
The spontaneous lysis of a coronary thrombus is a natural protective mechanism against lasting occlusion and downstream infarction. Thrombus stability is thus a direct determinant of clinical outcome. Compared with the extensive study of the crucial role of platelets, coagulation, and flow in arterial thrombosis, little attention has been paid to factors affecting thrombus stability, despite evidence linking impaired spontaneous fibrinolytic activity with acute coronary events. We summarize experimental evidence for the importance of thrombus stability and highlight the need for physiologically relevant tests to assess spontaneous disintegration/fibrinolysis of platelet-rich thrombi under arterial flow conditions, review techniques to assess thrombus stability in vitro, and describe novel imaging techniques to characterize thrombosis in vivo...
October 17, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28982495/the-importance-of-breakfast-in-atherosclerosis-disease-insights-from-the-pesa-study
#16
Irina Uzhova, Valentín Fuster, Antonio Fernández-Ortiz, José M Ordovás, Javier Sanz, Leticia Fernández-Friera, Beatriz López-Melgar, José M Mendiguren, Borja Ibáñez, Héctor Bueno, José L Peñalvo
BACKGROUND: Daily habits, including the number and quality of eating occasions, are potential targets for primary prevention strategies with large health impacts. Skipping breakfast is considered a frequent and unhealthy habit associated with an increased cardiovascular (CV) risk. OBJECTIVES: The study sought to explore the association between different breakfast patterns and CV risk factors and the presence, distribution, and extension of subclinical atherosclerosis...
October 10, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28955040/proteomic-footprint-of-myocardial-ischemia-reperfusion-injury-longitudinal-study-of-the-at-risk-and-remote-regions-in-the-pig-model
#17
Aleksandra Binek, Rodrigo Fernández-Jiménez, Inmaculada Jorge, Emilio Camafeita, Juan Antonio López, Navratan Bagwan, Carlos Galán-Arriola, Andres Pun, Jaume Agüero, Valentin Fuster, Borja Ibanez, Jesús Vázquez
Reperfusion alters post-myocardial infarction (MI) healing; however, very few systematic studies report the early molecular changes following ischemia/reperfusion (I/R). Alterations in the remote myocardium have also been neglected, disregarding its contribution to post-MI heart failure (HF) development. This study characterizes protein dynamics and contractile abnormalities in the ischemic and remote myocardium during one week after MI. Closed-chest 40 min I/R was performed in 20 pigs sacrificed at 120 min, 24 hours, 4days, and 7days after reperfusion (n = 5 per group)...
September 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28953444/investing-in-global-health-for-our-future
#18
Victor Dzau, Valentin Fuster, Jendayi Frazer, Megan Snair
With connectedness among countries increasing, the United States exists in a highly interdependent world. All countries are now vulnerable to the ever-present threats of infectious disease outbreaks and epidemics, as well as the continuous challenges of malaria, tuberculosis, and human..
September 28, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28843389/impact-factor-a-curious-and-capricious-metric
#19
EDITORIAL
Valentin Fuster
No abstract text is available yet for this article.
September 19, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28837213/antithrombotic-potency-of-ticagrelor-versus-clopidogrel-in-type-2-diabetic-patients-with-cardiovascular-disease
#20
M Urooj Zafar, Usman Baber, Donald A Smith, Samantha Sartori, Johanna Contreras, Juan Rey-Mendoza, Carlos A Linares-Koloffon, Gines Escolar, Roxana Mehran, Valentin Fuster, Juan J Badimon
Type-2 Diabetes Mellitus [T2DM] is associated with increased platelet reactivity and hypo-response to antiplatelet drugs. Ticagrelor, with its faster and more potent antiplatelet effects, was shown to reduce adverse events more than clopidogrel in the overall CAD patient population of PLATO trial, but the benefits did not reach statistical significance in the T2DM subgroup. To better understand these findings, we compared the antithrombotic effects of ticagrelor versus with clopidogrel in T2DM patients with cardiovascular disease...
October 5, 2017: Thrombosis and Haemostasis
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