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https://www.readbyqxmd.com/read/27908353/the-risk-continuum-of-atherosclerosis-and%C3%A2-its-implications-for-defining-chd-by%C3%A2-coronary-angiography
#1
REVIEW
Armin Arbab-Zadeh, Valentin Fuster
Patients undergoing coronary angiography for suspected coronary heart disease who are found to have coronary atherosclerotic disease with <50% diameter stenosis may carry a risk of adverse cardiac events similar to that in patients with single-vessel obstructive disease. Yet clinical practice guidelines offer no direction for managing symptomatic patients with nonobstructive coronary atherosclerosis because current diagnostic criteria for coronary heart disease are not met. Accordingly, secondary preventive measures are not endorsed, and their role is not defined in this setting...
December 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27888762/nutritional-preconditioning-by-marine-omega-3-fatty-acids-in-patients-with-st-segment-elevation-myocardial-infarction-a-metocard-cnic-trial-substudy
#2
Aleix Sala-Vila, Rodrigo Fernández-Jiménez, Gonzalo Pizarro, Carlos Calvo, Jose M García-Ruiz, Leticia Fernández-Friera, Maite D Rodriguez, Noemí Escalera, Jorge Palazuelos, Angel Macías, Braulio Pérez-Asenjo, Antonio Fernández-Ortiz, Emilio Ros, Valentín Fuster, Borja Ibáñez
No abstract text is available yet for this article.
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27886793/innovative-approaches-to-hypertension-control-in-low-and-middle-income-countries
#3
REVIEW
Rajesh Vedanthan, Antonio Bernabe-Ortiz, Omarys I Herasme, Rohina Joshi, Patricio Lopez-Jaramillo, Amanda G Thrift, Jacqui Webster, Ruth Webster, Karen Yeates, Joyce Gyamfi, Merina Ieremia, Claire Johnson, Jemima H Kamano, Maria Lazo-Porras, Felix Limbani, Peter Liu, Tara McCready, J Jaime Miranda, Sailesh Mohan, Olugbenga Ogedegbe, Brian Oldenburg, Bruce Ovbiagele, Mayowa Owolabi, David Peiris, Vilarmina Ponce-Lucero, Devarsetty Praveen, Arti Pillay, Jon-David Schwalm, Sheldon W Tobe, Kathy Trieu, Khalid Yusoff, Valentin Fuster
Elevated blood pressure, a major risk factor for ischemic heart disease, heart failure, and stroke, is the leading global risk for mortality. Treatment and control rates are very low in low- and middle-income countries. There is an urgent need to address this problem. The Global Alliance for Chronic Diseases sponsored research projects focus on controlling hypertension, including community engagement, salt reduction, salt substitution, task redistribution, mHealth, and fixed-dose combination therapies. This paper reviews the rationale for each approach and summarizes the experience of some of the research teams...
February 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/27872105/multiethnic-exome-wide-association-study-of-subclinical-atherosclerosis
#4
Pradeep Natarajan, Joshua C Bis, Lawrence F Bielak, Amanda J Cox, Marcus Dörr, Mary F Feitosa, Nora Franceschini, Xiuqing Guo, Shih-Jen Hwang, Aaron Isaacs, Min A Jhun, Maryam Kavousi, Ruifang Li-Gao, Leo-Pekka Lyytikäinen, Riccardo E Marioni, Ulf Schminke, Nathan O Stitziel, Hayato Tada, Jessica van Setten, Albert V Smith, Dina Vojinovic, Lisa R Yanek, Jie Yao, Laura M Yerges-Armstrong, Najaf Amin, Usman Baber, Ingrid B Borecki, J Jeffrey Carr, Yii-Der Ida Chen, L Adrienne Cupples, Pim A de Jong, Harry de Koning, Bob D de Vos, Ayse Demirkan, Valentin Fuster, Oscar H Franco, Mark O Goodarzi, Tamara B Harris, Susan R Heckbert, Gerardo Heiss, Udo Hoffmann, Albert Hofman, Ivana Išgum, J Wouter Jukema, Mika Kähönen, Sharon L R Kardia, Brian G Kral, Lenore J Launer, Joseph Massaro, Roxana Mehran, Braxton D Mitchell, Thomas H Mosley, Renée de Mutsert, Anne B Newman, Khanh-Dung Nguyen, Kari E North, Jeffrey R O'Connell, Matthijs Oudkerk, James S Pankow, Gina M Peloso, Wendy Post, Michael A Province, Laura M Raffield, Olli T Raitakari, Dermot F Reilly, Fernando Rivadeneira, Frits Rosendaal, Samantha Sartori, Kent D Taylor, Alexander Teumer, Stella Trompet, Stephen T Turner, André G Uitterlinden, Dhananjay Vaidya, Aad van der Lugt, Uwe Völker, Joanna M Wardlaw, Christina L Wassel, Stefan Weiss, Mary K Wojczynski, Diane M Becker, Lewis C Becker, Eric Boerwinkle, Donald W Bowden, Ian J Deary, Abbas Dehghan, Stephan B Felix, Vilmundur Gudnason, Terho Lehtimäki, Rasika Mathias, Dennis O Mook-Kanamori, Bruce M Psaty, Daniel J Rader, Jerome I Rotter, James G Wilson, Cornelia M van Duijn, Henry Völzke, Sekar Kathiresan, Patricia A Peyser, Christopher J O'Donnell
BACKGROUND: -The burden of subclinical atherosclerosis in asymptomatic individuals is heritable and associated with elevated risk of developing clinical coronary heart disease (CHD). We sought to identify genetic variants in protein-coding regions associated with subclinical atherosclerosis and the risk of subsequent CHD. METHODS AND RESULTS: -We studied a total of 25,109 European ancestry and African-American participants with coronary artery calcification (CAC) measured by cardiac computed tomography and 52,869 with common carotid intima media thickness (CIMT) measured by ultrasonography within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium...
November 21, 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/27816118/relation-of-post-coronary-artery-bypass-graft-creatine-kinase-mb-elevations-and-new-q-waves-with-long-term-cardiovascular-death-in-patients-with-diabetes-mellitus-and-multivessel-coronary-artery-disease
#5
Michael Domanski, Michael E Farkouh, Victor Zak, John French, John H Alexander, Andrzej Bochenek, Martial Hamon, Kenneth Mahaffey, John Puskas, Peter Smith, Peter Shrader, Valentin Fuster
Associations of early creatine phosphokinase-MB (CK-MB) elevation and new Q waves and their association with cardiovascular death (CVD) after coronary artery bypass grafting (CABG) have been reported, but this association has not been studied in a large population of patients with diabetes mellitus. In this study, we examine the association of periprocedural CK-MB elevations and new Q waves with CVD in the Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease trial...
August 30, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27793511/cultural-third-world-war-how-economic-disparity-adversely%C3%A2-affects%C3%A2-health
#6
EDITORIAL
Valentin Fuster
No abstract text is available yet for this article.
October 26, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27712639/antithrombotic-approaches-in-acute-coronary-syndromes-optimizing-benefit-vs-bleeding-risks
#7
Mandeep Singh, Deepak L Bhatt, Gregg W Stone, Charanjit S Rihal, Bernard J Gersh, Ryan J Lennon, Jagat Narula, Valentin Fuster
It is estimated that in the United States, each year, approximately 620,000 persons will experience an acute coronary syndrome and approximately 70% of these will have non-ST-elevation acute coronary syndrome. Cardiovascular disease still accounts for 1 of every 3 deaths in the United States, and there is an urgent need to improve the prognosis of patients presenting with acute coronary syndrome. Cardiovascular mortality and ischemic complications are common after acute coronary syndrome, and the advent of newer antithrombotic therapies has reduced ischemic complications, but at the expense of greater bleeding...
October 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27635081/the-cnic-a-successful-vision-in-cardiovascular-research
#8
Valentín Fuster, Borja Ibáñez, Vicente Andrés
No abstract text is available yet for this article.
September 16, 2016: Circulation Research
https://www.readbyqxmd.com/read/27601365/magnetic-resonance-characterization-of-cardiac-adaptation-and-myocardial-fibrosis-in-pulmonary-hypertension-secondary-to-systemic-to-pulmonary-shunt
#9
Daniel Pereda, Inés García-Lunar, Federico Sierra, Damián Sánchez-Quintana, Evelyn Santiago, Constanza Ballesteros, Juan F Encalada, Javier Sánchez-González, Valentín Fuster, Borja Ibáñez, Ana García-Álvarez
BACKGROUND: Pulmonary hypertension (PH) and right ventricular (RV) dysfunction are strong predictors of morbidity and mortality among patients with congenital heart disease. Early detection of RV involvement may be useful in the management of these patients. We aimed to assess progressive cardiac adaptation and quantify myocardial extracellular volume in an experimental porcine model of PH because of aorto-pulmonary shunt using cardiac magnetic resonance (CMR). METHODS AND RESULTS: To characterize serial cardiac adaptation, 12 pigs (aorto-pulmonary shunt [n=6] or sham operation [n=6]) were evaluated monthly with right heart catheterization, CMR, and computed tomography during 4 months, followed by pathology analysis...
September 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27592277/accuracy-of-area-at-risk-quantification-by-cardiac-magnetic-resonance-according-to-the-myocardial-infarction-territory
#10
Leticia Fernández-Friera, José Manuel García-Ruiz, Ana García-Álvarez, Rodrigo Fernández-Jiménez, Javier Sánchez-González, Xavier Rossello, Sandra Gómez-Talavera, Gonzalo J López-Martín, Gonzalo Pizarro, Valentín Fuster, Borja Ibáñez
INTRODUCTION AND OBJECTIVES: Area at risk (AAR) quantification is important to evaluate the efficacy of cardioprotective therapies. However, postinfarction AAR assessment could be influenced by the infarcted coronary territory. Our aim was to determine the accuracy of T2-weighted short tau triple-inversion recovery (T2W-STIR) cardiac magnetic resonance (CMR) imaging for accurate AAR quantification in anterior, lateral, and inferior myocardial infarctions. METHODS: Acute reperfused myocardial infarction was experimentally induced in 12 pigs, with 40-minute occlusion of the left anterior descending (n = 4), left circumflex (n = 4), and right coronary arteries (n = 4)...
August 31, 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/27585501/medical-treatment-and-revascularization-options-in-patients-with-type-2-diabetes-and-coronary-disease
#11
G B John Mancini, Michael E Farkouh, Maria M Brooks, Bernard R Chaitman, William E Boden, Helen Vlachos, Pamela M Hartigan, Flora S Siami, Mandeep S Sidhu, Vera Bittner, Robert Frye, Valentin Fuster
BACKGROUND: There are scant outcomes data in patients with type 2 diabetes and stable coronary artery disease (CAD) stratified by detailed angiographic burden of CAD or left ventricular ejection fraction (LVEF). OBJECTIVES: This study determined the effect of optimal medical therapy (OMT), with or without percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), on long-term outcomes with respect to LVEF and number of diseased vessels, including proximal left anterior descending artery involvement...
September 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27572072/comparative-efficacy-of-coronary-artery-bypass-surgery-vs-percutaneous-coronary-intervention-in-patients-with-diabetes-and-multivessel-coronary-artery-disease-with-or-without-chronic-kidney-disease
#12
Usman Baber, Michael E Farkouh, Yaron Arbel, Paul Muntner, George Dangas, Michael J Mack, Taye H Hamza, Roxana Mehran, Valentin Fuster
BACKGROUND: The optimal method of coronary revascularization among patients with diabetes mellitus (DM) and multivessel coronary artery disease (CAD) complicated by chronic kidney disease (CKD) remains unknown. PURPOSE: To examine the impact of coronary artery bypass surgery (CABG) vs. percutaneous coronary intervention (PCI) on cardiovascular outcomes in patients with diabetes with and without CKD. METHODS: We conducted an 'as-treated' subgroup analysis of the FREEDOM trial to examine the therapeutic efficacy of CABG vs...
August 29, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27561760/a-simple-disease-guided-approach-to-personalize-acc-aha-recommended-statin%C3%A2-allocation-in-elderly-people-the-bioimage-study
#13
Martin Bødtker Mortensen, Valentin Fuster, Pieter Muntendam, Roxana Mehran, Usman Baber, Samantha Sartori, Erling Falk
BACKGROUND: The 2013 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines recommend primary prevention with statins for individuals with ≥7.5% 10-year risk for atherosclerotic cardiovascular disease (ASCVD). Everyone living long enough will become eligible for risk-based statin therapy due to age alone. OBJECTIVES: This study sought to personalize ACC/AHA risk-based statin eligibility using noninvasive assessment of subclinical atherosclerosis...
August 30, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27539181/unlikely-allies-partnering-with-the-food-industry-to-fight-the-obesity-epidemic
#14
EDITORIAL
Valentin Fuster
No abstract text is available yet for this article.
August 23, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27539172/association-between-a-social-business%C3%A2-eating-pattern-and-early%C3%A2-asymptomatic-atherosclerosis
#15
José L Peñalvo, Leticia Fernández-Friera, Beatriz López-Melgar, Irina Uzhova, Belén Oliva, Juan Miguel Fernández-Alvira, Martín Laclaustra, Stuart Pocock, Agustín Mocoroa, José M Mendiguren, Ginés Sanz, Eliseo Guallar, Sameer Bansilal, Rajesh Vedanthan, Luis Jesús Jiménez-Borreguero, Borja Ibañez, José M Ordovás, Antonio Fernández-Ortiz, Héctor Bueno, Valentin Fuster
BACKGROUND: The importance of a healthy diet in relation to cardiovascular health promotion is widely recognized. Identifying specific dietary patterns related to early atherosclerosis would contribute greatly to inform effective primary prevention strategies. OBJECTIVES: This study sought to quantify the association between specific dietary patterns and presence and extent of subclinical atherosclerosis in a population of asymptomatic middle-aged adults. METHODS: The PESA (Progression of Early Subclinical Atherosclerosis) study enrolled 4,082 asymptomatic participants 40 to 54 years of age (mean age 45...
August 23, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27539170/assessing-the-impact-of-medication%C3%A2-adherence-on-long-term-cardiovascular-outcomes
#16
Sameer Bansilal, Jose Maria Castellano, Ester Garrido, Henry G Wei, Allison Freeman, Claire Spettell, Fernando Garcia-Alonso, Irene Lizano, Renee J G Arnold, Jay Rajda, Gregory Steinberg, Valentin Fuster
BACKGROUND: Although guideline-recommended therapies reduce major adverse cardiovascular events (MACE) in patients after myocardial infarction (MI) or those with atherosclerotic disease (ATH), adherence is poor. OBJECTIVES: The goal of this study was to determine the association between medication adherence levels and long-term MACE in these patients. METHODS: We queried the claims database of a large health insurer for patients hospitalized for MI or with ATH...
August 23, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27474481/usefulness-of-a-cardiovascular-polypill-in-the-treatment-of-secondary-prevention-patients-in-spain-a-cost-effectiveness-study
#17
Vivencio Barrios, Lisette Kaskens, José María Castellano, Juan Cosin-Sales, José Emilio Ruiz, Ilonka Zsolt, Valentín Fuster, Alfredo Gracia
INTRODUCTION AND OBJECTIVES: To estimate the health benefits and cost-effectiveness of a polypill intervention (aspirin 100 mg, atorvastatin 20 mg, ramipril 10 mg) compared with multiple monotherapy for secondary prevention of cardiovascular events in adults with a history of myocardial infarction from the perspective of the Spanish National Health System. METHODS: An adapted version of a recently published Markov model developed and validated in Microsoft Excel was used to compare the cost-effectiveness of the polypill with that of its combined monocomponents over a 10-year time horizon...
July 26, 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/27440970/barriers-and-facilitators-to-nurse-management-of-hypertension-a-qualitative-analysis-from-western-kenya
#18
Rajesh Vedanthan, Nelly Tuikong, Claire Kofler, Evan Blank, Jemima H Kamano, Violet Naanyu, Sylvester Kimaiyo, Thomas S Inui, Carol R Horowitz, Valentin Fuster
BACKGROUND: Hypertension is the leading global risk for mortality. Poor treatment and control of hypertension in low- and middle-income countries is due to several reasons, including insufficient human resources. Nurse management of hypertension is a novel approach to address the human resource challenge. However, specific barriers and facilitators to this strategy are not known. OBJECTIVE: To evaluate barriers and facilitators to nurse management of hypertensive patients in rural western Kenya, using a qualitative research approach...
2016: Ethnicity & Disease
https://www.readbyqxmd.com/read/27383079/stroke-risk-assessment-in-atrial-fibrillation-risk-factors-and-markers-of-atrial-myopathy
#19
REVIEW
Brandon W Calenda, Valentin Fuster, Jonathan L Halperin, Christopher B Granger
Atrial fibrillation (AF) is a complex phenomenon associated with electrical, mechanical, and structural abnormalities of the atria. Ischaemic stroke in AF is only partially understood, but the mechanisms are known to be related to the atrial substrate as well as the atrial rhythm. The temporal dissociation between timing of AF and occurrence of stroke has led to the hypothesis that fibrotic, prothrombotic atrial tissue is an important cause of thrombus formation in patients with AF, independent of the atrial rhythm...
September 2016: Nature Reviews. Cardiology
https://www.readbyqxmd.com/read/27381860/acute-coronary-syndromes-in-low-and-middle-income-countries-moving-forward
#20
Benjamin Seligman, Rajesh Vedanthan, Valentin Fuster
Cardiovascular disease remains the leading cause of death worldwide, particularly in low- and middle-income countries (LMICs), with substantial mortality from acute coronary syndromes. These deaths, when compared against high-income countries, occur at younger ages, and, beyond the lives lost, often result in economic privation for families deprived of a breadwinner and indebted by the oftentimes catastrophic cost of inpatient medical care. This burden will likely grow in scale in the years ahead as more countries pass through the epidemiologic transition...
August 2016: International Journal of Cardiology
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