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https://www.readbyqxmd.com/read/28416795/neutrophil-stunning-by-metoprolol-reduces-infarct-size
#1
Jaime García-Prieto, Rocío Villena-Gutiérrez, Mónica Gómez, Esther Bernardo, Andrés Pun-García, Inés García-Lunar, Georgiana Crainiciuc, Rodrigo Fernández-Jiménez, Vinatha Sreeramkumar, Rafael Bourio-Martínez, José M García-Ruiz, Alfonso Serrano Del Valle, David Sanz-Rosa, Gonzalo Pizarro, Antonio Fernández-Ortiz, Andrés Hidalgo, Valentín Fuster, Borja Ibanez
The β1-adrenergic-receptor (ADRB1) antagonist metoprolol reduces infarct size in acute myocardial infarction (AMI) patients. The prevailing view has been that metoprolol acts mainly on cardiomyocytes. Here, we demonstrate that metoprolol reduces reperfusion injury by targeting the haematopoietic compartment. Metoprolol inhibits neutrophil migration in an ADRB1-dependent manner. Metoprolol acts during early phases of neutrophil recruitment by impairing structural and functional rearrangements needed for productive engagement of circulating platelets, resulting in erratic intravascular dynamics and blunted inflammation...
April 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28341414/myocardial-extracellular-volume-is-not-associated-with-malignant-ventricular-arrhythmias-in-high-risk-hypertrophic-cardiomyopathy
#2
Jesús G Mirelis, Javier Sánchez-González, Esther Zorio, Tomas Ripoll-Vera, Rafael Salguero-Bodes, David Filgueiras-Rama, Esther González-López, María Gallego-Delgado, Rodrigo Fernández-Jiménez, María Jesús Soleto, Juana Núñez, Gonzalo Pizarro, Javier Sanz, Valentín Fuster, Pablo García-Pavía, Borja Ibáñez
INTRODUCTION AND OBJECTIVES: Myocardial interstitial fibrosis, a hallmark of hypertrophic cardiomyopathy (HCM), has been proposed as an arrhythmic substrate. Fibrosis is associated with increased extracellular volume (ECV), which can be quantified by computed tomography (CT). We aimed to analyze the association between CT-determined ECV and malignant ventricular arrhythmias. METHODS: A retrospective case-control observational study was conducted in HCM patients with implantable cardioverter-defibrillator, undergoing a CT-protocol with continuous iodine contrast infusion to determine equilibrium ECV...
March 21, 2017: Revista Española de Cardiología
https://www.readbyqxmd.com/read/28335846/the-proliferation-of-scoring%C3%A2-systems-trying-to-keep-our-heads-out-of-the-clouds
#3
EDITORIAL
Valentin Fuster
No abstract text is available yet for this article.
March 28, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28302548/availability-use-and-barriers-to-cardiac-rehabilitation-in-lmic
#4
Loheetha Ragupathi, Judy Stribling, Yuliya Yakunina, Valentin Fuster, Mary Ann McLaughlin, Rajesh Vedanthan
BACKGROUND: Cardiac rehabilitation (CR) is a cornerstone of secondary prevention of ischemic heart disease. It is critically important in low- and middle-income countries (LMIC), where the burden of ischemic heart disease is substantial and growing. However, the availability and utilization of CR in LMIC is not systematically known. OBJECTIVES: This study sought to characterize the availability, use, and barriers to the use of CR. METHODS: Electronic databases (Cochrane Library, EMBASE, PubMed, Web of Science) were searched from January 1, 1980 to May 31, 2013 for articles on CR in LMIC...
March 13, 2017: Global Heart
https://www.readbyqxmd.com/read/28224926/a-30-month-worksite-based-lifestyle-program-to-promote-cardiovascular-health-in-middle-aged-bank-employees-design-of-the-tansnip-pesa-randomized-controlled-trial
#5
Jennifer K Coffeng, Hidde P van der Ploeg, José M Castellano, Juan M Fernández-Alvira, Borja Ibáñez, Inés García-Lunar, Allard J van der Beek, Antonio Fernández-Ortiz, Agustín Mocoroa, Laura García-Leal, Evelyn Cárdenas, Carolina Rojas, María I Martínez-Castro, Silvia Santiago-Sacristán, Miriam Fernández-Gallardo, José M Mendiguren, Sameer Bansilal, Willem van Mechelen, Valentín Fuster
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of death worldwide. With atherosclerosis as the underlying cause for many CVD events, prevention or reduction of subclinical atherosclerotic plaque burden (SAPB) through a healthier lifestyle may have substantial public health benefits. OBJECTIVE: The objective was to describe the protocol of a randomized controlled trial investigating the effectiveness of a 30-month worksite-based lifestyle program aimed to promote cardiovascular health in participants having a high or a low degree of SAPB compared with standard care...
February 2017: American Heart Journal
https://www.readbyqxmd.com/read/28223407/polygenic-risk-score-identifies-subgroup-with-higher-burden-of-atherosclerosis-and-greater-relative-benefit-from-statin-therapy-in-the-primary-prevention-setting
#6
Pradeep Natarajan, Robin Young, Nathan O Stitziel, Sandosh Padmanabhan, Usman Baber, Roxana Mehran, Samantha Sartori, Valentin Fuster, Dermot F Reilly, Adam S Butterworth, Daniel J Rader, Ian Ford, Naveed Sattar, Sekar Kathiresan
Background -Relative risk reduction with statin therapy has been consistent across nearly all subgroups studied to date. However, in analyses of two randomized controlled primary prevention trials (ASCOT and JUPITER), statin therapy led to a greater relative risk reduction among a subgroup at high genetic risk. Here, we sought to confirm this observation in a third primary prevention randomized controlled trial. Additionally, we assessed if those at high genetic risk had a greater burden of subclinical coronary atherosclerosis...
February 21, 2017: Circulation
https://www.readbyqxmd.com/read/28205517/corrigendum-endothelial-to-mesenchymal-transition-is-common-in-atherosclerotic-lesions-and-is-associated-with-plaque-instability
#7
Solene M Evrard, Laura Lecce, Katherine C Michelis, Aya Nomura-Kitabayashi, Gaurav Pandey, K-Raman Purushothaman, Valentina d'Escamard, Jennifer R Li, Lahouaria Hadri, Kenji Fujitani, Pedro R Moreno, Ludovic Benard, Pauline Rimmele, Ariella Cohain, Brigham Mecham, Gwendalyn J Randolph, Elizabeth G Nabel, Roger Hajjar, Valentin Fuster, Manfred Boehm, Jason C Kovacic
No abstract text is available yet for this article.
February 16, 2017: Nature Communications
https://www.readbyqxmd.com/read/28188434/bloodless-reperfusion-with-the-oxygen-carrier-hboc-201-in-acute-myocardial-infarction-a-novel-platform-for-cardioprotective-probes-delivery
#8
Jose M García-Ruiz, Carlos Galán-Arriola, Rodrigo Fernández-Jiménez, Jaume Aguero, Javier Sánchez-González, Ana García-Alvarez, Mario Nuno-Ayala, Gregory P Dubé, Zafiris Zafirelis, Gonzalo J López-Martín, Juan A Bernal, Enrique Lara-Pezzi, Valentín Fuster, Borja Ibáñez
Reperfusion, despite being required for myocardial salvage, is associated with additional injury. We hypothesize that infarct size (IS) will be reduced by a period of bloodless reperfusion with hemoglobin-based oxygen carriers (HBOC) before blood-flow restoration. In the pig model, we first characterized the impact of intracoronary perfusion with a fixed volume (600 ml) of a pre-oxygenated acellular HBOC, HBOC-201, on the healthy myocardium. HBOC-201 was administered through the lumen of the angioplasty balloon (i...
March 2017: Basic Research in Cardiology
https://www.readbyqxmd.com/read/28166827/the-polypill-approach-an-innovative-strategy-to-improve-cardiovascular-health-in-europe
#9
Valentín Fuster, Francesc Gambús, Aldo Patriciello, Margaretha Hamrin, Diederick E Grobbee
BACKGROUND: Cardiovascular disease (CVD) is a major cause of disability and premature death. Despite European guidelines advocating the use of medical therapies in CVD, many patients still do not achieve the guideline-recommended treatment, which highlights the need for change and innovations in this field. This requirement has been widely recognised by the national ministries of health, several European cardiology societies, and the European Parliament, who support the initiation of strategies to improve and promote cardiovascular health...
February 7, 2017: BMC Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28109921/coronary-artery-pet-mr-imaging-feasibility-limitations-and-solutions
#10
Philip M Robson, Marc R Dweck, Maria Giovanna Trivieri, Ronan Abgral, Nicolas A Karakatsanis, Johanna Contreras, Umesh Gidwani, Jagat P Narula, Valentin Fuster, Jason C Kovacic, Zahi A Fayad
OBJECTIVES: The aims of this study were to describe the authors' initial experience with combined coronary artery positron emission tomographic (PET) and magnetic resonance (MR) imaging using (18)F-fluorodeoxyglucose ((18)F-FDG) and (18)F-sodium fluoride ((18)F-NaF) radiotracers, describe common problems and their solutions, and demonstrate the feasibility of coronary PET/MR imaging in appropriate patients. BACKGROUND: Recently, PET imaging has been applied to the aortic valve and regions of atherosclerosis...
January 13, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28104071/cardiac-autonomic-dysfunction-and-incidence-of-atrial-fibrillation-results-from-20-years-follow-up
#11
Sunil K Agarwal, Faye L Norby, Eric A Whitsel, Elsayed Z Soliman, Lin Y Chen, Laura R Loehr, Valentin Fuster, Gerardo Heiss, Josef Coresh, Alvaro Alonso
BACKGROUND: Cardiac autonomic perturbations frequently antecede onset of paroxysmal atrial fibrillation (AF). Interventions that influence autonomic inputs to myocardium may prevent AF. However, whether low heart rate or heart rate variability (HRV), which are noninvasive measures of cardiac autonomic dysfunction, are associated with AF incidence is unclear. OBJECTIVES: This study sought to study the association between HRV and risk of AF. METHODS: This study included 11,715 middle-aged adults in the ARIC (Atherosclerosis Risk In Communities) cohort with heart rate and HRV measures obtained from 2-min electrocardiogram recordings performed at baseline (1987 to 1989)...
January 24, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28061997/evaluation-of-the-pooled-cohort-equations-for-prediction-of-cardiovascular-risk-in-a-contemporary-prospective-cohort
#12
Connor A Emdin, Amit V Khera, Pradeep Natarajan, Derek Klarin, Usman Baber, Roxana Mehran, Daniel J Rader, Valentin Fuster, Sekar Kathiresan
Most guidelines suggest a baseline risk assessment to guide atherosclerotic cardiovascular disease (ASCVD) prevention strategies. The American Heart Association/American College of Cardiology Pooled Cohort Equations (PCEs) is one tool to assess baseline risk; however, the accuracy of this tool has been called into question. We aimed to examine the calibration and discrimination of the PCEs in the BioImage study, a contemporary multiethnic cohort of asymptomatic adults enrolled from 2008 to 2009 in the Humana Health System in Chicago, Illinois, and Fort Lauderdale, Florida...
March 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28057233/a-devotion-to-never-feeling-satisfied-new-jacc-content-avenues
#13
EDITORIAL
Valentin Fuster
No abstract text is available yet for this article.
January 3, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27993926/oxidized-ldl-is-associated-with-metabolic-syndrome-traits-independently-of-central-obesity-and-insulin-resistance
#14
Yamilee Hurtado-Roca, Hector Bueno, Antonio Fernandez-Ortiz, Jose Maria Ordovas, Borja Ibañez, Valentin Fuster, Fernando Rodriguez-Artalejo, Martin Laclaustra
This study assesses whether oxidative stress, using oxidized LDL (ox-LDL) as proxy, is associated with metabolic syndrome (MS), whether ox-LDL mediates the association between central obesity and MS, and whether insulin resistance mediates the association between ox-LDL and MS. We examined baseline data from 3987 non-diabetic subjects in the Progression of Early Subclinical Atherosclerosis (PESA) Study. For the 2nd, 3rd, and 4th ox-LDL quartiles versus the 1st, the odds ratios (95% confidence interval) for MS were 0...
December 19, 2016: Diabetes
https://www.readbyqxmd.com/read/27988210/neuropilin1-regulates-glomerular-function-and-basement-membrane-composition-through-pericytes-in-the-mouse-kidney
#15
Monika Wnuk, Manuel A Anderegg, Werner A Graber, Regula Buergy, Daniel G Fuster, Valentin Djonov
Neuropilin1 (Nrp1) is a co-receptor best known to regulate the development of endothelial cells and is a target of anticancer therapies. However, its role in other vascular cells including pericytes is emergent. The kidney is an organ with high pericyte density and cancer patients develop severe proteinuria following administration of NRP1B-neutralizing antibody combined with bevacizumab. Therefore, we investigated whether Nrp1 regulates glomerular capillary integrity after completion of renal development using two mouse models; tamoxifen-inducible NG2Cre to delete Nrp1 specifically in pericytes and administration of Nrp1-neutralizing antibodies...
December 14, 2016: Kidney International
https://www.readbyqxmd.com/read/27959714/genetic-risk-adherence-to-a-healthy-lifestyle-and-coronary-disease
#16
Amit V Khera, Connor A Emdin, Isabel Drake, Pradeep Natarajan, Alexander G Bick, Nancy R Cook, Daniel I Chasman, Usman Baber, Roxana Mehran, Daniel J Rader, Valentin Fuster, Eric Boerwinkle, Olle Melander, Marju Orho-Melander, Paul M Ridker, Sekar Kathiresan
BACKGROUND: Both genetic and lifestyle factors contribute to individual-level risk of coronary artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle is unknown. METHODS: Using a polygenic score of DNA sequence polymorphisms, we quantified genetic risk for coronary artery disease in three prospective cohorts - 7814 participants in the Atherosclerosis Risk in Communities (ARIC) study, 21,222 in the Women's Genome Health Study (WGHS), and 22,389 in the Malmö Diet and Cancer Study (MDCS) - and in 4260 participants in the cross-sectional BioImage Study for whom genotype and covariate data were available...
December 15, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27938844/little-beacons-of-change-targeting-preschool-children-to-drive-a-culture-of-health
#17
EDITORIAL
Jacqueline Latina, Sameer Bansilal, Rajesh Vedanthan, Valentin Fuster
No abstract text is available yet for this article.
December 2016: Global Heart
https://www.readbyqxmd.com/read/27938821/cardiovascular-diseases-on-the-global-agenda-the-united-nations-high-level-meeting-sustainable-development-goals-and-the-way-forward
#18
REVIEW
Johanna Ralston, K Srinath Reddy, Valentin Fuster, Jagat Narula
In 2011, the United Nations (UN) organized the first ever meeting for heads of state to discuss the problem of noncommunicable diseases (NCD), including cardiovascular disease (CVD), cancer, chronic respiratory disease, and diabetes mellitus. Recognizing that these had emerged as leading causes of morbidity and mortality in the world, including in many low- and middle-income countries, advocates from government and civil society had called for increased attention and a UN response. Earlier, NCD including CVD were absent from the global health agenda in part because of their omission from the Millennium Development Goals...
December 2016: Global Heart
https://www.readbyqxmd.com/read/27908353/the-risk-continuum-of-atherosclerosis-and%C3%A2-its-implications-for-defining-chd-by%C3%A2-coronary-angiography
#19
REVIEW
Armin Arbab-Zadeh, Valentin Fuster
Patients undergoing coronary angiography for suspected coronary heart disease who are found to have coronary atherosclerotic disease with <50% diameter stenosis may carry a risk of adverse cardiac events similar to that in patients with single-vessel obstructive disease. Yet clinical practice guidelines offer no direction for managing symptomatic patients with nonobstructive coronary atherosclerosis because current diagnostic criteria for coronary heart disease are not met. Accordingly, secondary preventive measures are not endorsed, and their role is not defined in this setting...
December 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27888762/nutritional-preconditioning-by-marine-omega-3-fatty-acids-in-patients-with-st-segment-elevation-myocardial-infarction-a-metocard-cnic-trial-substudy
#20
Aleix Sala-Vila, Rodrigo Fernández-Jiménez, Gonzalo Pizarro, Carlos Calvo, Jose M García-Ruiz, Leticia Fernández-Friera, Maite D Rodriguez, Noemí Escalera, Jorge Palazuelos, Angel Macías, Braulio Pérez-Asenjo, Antonio Fernández-Ortiz, Emilio Ros, Valentín Fuster, Borja Ibáñez
No abstract text is available yet for this article.
February 1, 2017: International Journal of Cardiology
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