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valentin fuster

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https://www.readbyqxmd.com/read/28801077/myocardial-amyloid-quantification-with-look-locker-magnetic-resonance-sequence-in-cardiac-amyloidosis-diagnostic-accuracy-in-clinical-practice-and-histological-validation
#1
Eduardo Pozo, Jose M Castellano, Anubhav Kanwar, Rajiv Deochand, Mireia Castillo-Martin, Pablo Pazos-López, Carlos González-Lengua, Keren Osman, Matthew Cham, Carlos Cordon-Cardo, Jagat Narula, Valentin Fuster, Javier Sanz
BACKGROUND: Cardiac magnetic resonance (CMR) has demonstrated its utility in the non-invasive diagnosis of cardiac amyloidosis (CA). Our aim was to evaluate the ability of standard Look-Locker sequences to quantify amyloid deposition in CA. METHODS AND RESULTS: Consecutive patients referred for CMR for possible CA were retrospectively evaluated. Positive cardiac biopsy and/or typical pattern of late gadolinium enhancement were required for the diagnosis of CA. Post-contrast T1 values were obtained from Look-Locker sequences, and correlated with markers of severity of disease and major events...
August 8, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28768756/impact-of-timing-on-the-functional-recovery-achieved-with-platelet-supplementation-after-treatment-with-ticagrelor
#2
M Urooj Zafar, Donald A Smith, Usman Baber, Samantha Sartori, Kevin Chen, David W Lam, Carlos A Linares-Koloffon, Juan Rey-Mendoza, Gustavo Jimenez Britez, Gines Escolar, Valentin Fuster, Juan J Badimon
BACKGROUND: American College of Cardiology/American Heart Association guidelines advise waiting 5 to 7 days before operating on P2Y12 inhibitor-treated acute coronary syndrome patients, to allow dissipation of its antiplatelet effects. Platelet transfusion is often used to restore hemostasis during operations, but its effectiveness and optimal timing are unclear. We investigated the degree of functional gains obtained from platelet supplementation after loading and maintenance of dual antiplatelet therapy with ticagrelor and the influence of timing on this strategy...
August 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28705310/subclinical-atherosclerosis-burden-by-3d%C3%A2-ultrasound-in-mid-life-the-pesa-study
#3
Beatriz López-Melgar, Leticia Fernández-Friera, Belén Oliva, José Manuel García-Ruiz, José Luis Peñalvo, Sandra Gómez-Talavera, Javier Sánchez-González, José María Mendiguren, Borja Ibáñez, Antonio Fernández-Ortiz, Javier Sanz, Valentín Fuster
BACKGROUND: Detection of subclinical atherosclerosis improves risk prediction beyond cardiovascular risk factors (CVRFs) and risk scores, but quantification of plaque burden may improve it further. Novel 3-dimensional vascular ultrasound (3DVUS) provides accurate volumetric quantification of plaque burden. OBJECTIVES: The authors evaluated associations between 3DVUS-based plaque burden and CVRFs and explored potential added value over simple plaque detection. METHODS: The authors included 3,860 (92...
July 18, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28697239/cardiovascular-risk-factor-control-for-all
#4
Philip Greenland, Valentin Fuster
No abstract text is available yet for this article.
July 11, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28687712/dynamic-edematous-response-of-the-human-heart-to-myocardial-infarction-implications-for-assessing-myocardial-area-at-risk-and-salvage
#5
Rodrigo Fernández-Jiménez, Manuel Barreiro-Pérez, Ana Martin-García, Javier Sánchez-González, Jaume Agüero, Carlos Galán-Arriola, Jaime García-Prieto, Elena Díaz-Pelaez, Pedro Vara, Irene Martinez, Ivan Zamarro, Beatriz Garde, Javier Sanz, Valentin Fuster, Pedro L Sánchez, Borja Ibanez
Background -Clinical protocols aimed to characterize the post-myocardial infarction (MI) heart by cardiac magnetic resonance (CMR) need to be standardized to take account of dynamic biological phenomena evolving early after the index ischemic event. Here we evaluated the time-course of edema reaction in ST-segment elevation MI (STEMI) patients by CMR and assessed its implications for myocardium-at-risk (MaR) quantification both in patients and in a large animal model. Methods -A total of 16 anterior STEMI patients successfully treated by primary angioplasty and 16 matched controls were prospectively recruited...
July 7, 2017: Circulation
https://www.readbyqxmd.com/read/28683970/oxidative-stress-and-cardiovascular-risk-obesity-diabetes-smoking-and-pollution-part-3-of-a-3-part-series
#6
REVIEW
Bernd Niemann, Susanne Rohrbach, Mark R Miller, David E Newby, Valentin Fuster, Jason C Kovacic
Oxidative stress occurs whenever the release of reactive oxygen species (ROS) exceeds endogenous antioxidant capacity. In this paper, we review the specific role of several cardiovascular risk factors in promoting oxidative stress: diabetes, obesity, smoking, and excessive pollution. Specifically, the risk of developing heart failure is higher in patients with diabetes or obesity, even with optimal medical treatment, and the increased release of ROS from cardiac mitochondria and other sources likely contributes to the development of cardiac dysfunction in this setting...
July 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28683969/impact-of-oxidative-stress-on-the-heart%C3%A2-and-vasculature-part-2-of-a-3-part-series
#7
REVIEW
Thomas Münzel, Giovanni G Camici, Christoph Maack, Nicole R Bonetti, Valentin Fuster, Jason C Kovacic
Vascular disease and heart failure impart an enormous burden in terms of global morbidity and mortality. Although there are many different causes of cardiac and vascular disease, most causes share an important pathological mechanism: oxidative stress. In the failing heart, oxidative stress occurs in the myocardium and correlates with left ventricular dysfunction. Reactive oxygen species (ROS) negatively affect myocardial calcium handling, cause arrhythmia, and contribute to cardiac remodeling by inducing hypertrophic signaling, apoptosis, and necrosis...
July 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28683968/basic-biology-of-oxidative-stress-and-the%C3%A2-cardiovascular-system-part-1-of-a-3-part-series
#8
REVIEW
Michael N Sack, Frej Y Fyhrquist, Outi J Saijonmaa, Valentin Fuster, Jason C Kovacic
The generation of reactive oxygen species (ROS) is a fundamental aspect of normal human biology. However, when ROS generation exceeds endogenous antioxidant capacity, oxidative stress arises. If unchecked, ROS production and oxidative stress mediate tissue and cell damage that can spiral in a cycle of inflammation and more oxidative stress. This article is part 1 of a 3-part series covering the role of oxidative stress in cardiovascular disease. The broad theme of this first paper is the mechanisms and biology of oxidative stress...
July 11, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28636844/clonal-hematopoiesis-and-risk-of-atherosclerotic-cardiovascular-disease
#9
Siddhartha Jaiswal, Pradeep Natarajan, Alexander J Silver, Christopher J Gibson, Alexander G Bick, Eugenia Shvartz, Marie McConkey, Namrata Gupta, Stacey Gabriel, Diego Ardissino, Usman Baber, Roxana Mehran, Valentin Fuster, John Danesh, Philippe Frossard, Danish Saleheen, Olle Melander, Galina K Sukhova, Donna Neuberg, Peter Libby, Sekar Kathiresan, Benjamin L Ebert
BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the presence of an expanded somatic blood-cell clone in persons without other hematologic abnormalities, is common among older persons and is associated with an increased risk of hematologic cancer. We previously found preliminary evidence for an association between CHIP and atherosclerotic cardiovascular disease, but the nature of this association was unclear. METHODS: We used whole-exome sequencing to detect the presence of CHIP in peripheral-blood cells and associated such presence with coronary heart disease using samples from four case-control studies that together enrolled 4726 participants with coronary heart disease and 3529 controls...
July 13, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/28624396/hybrid-magnetic-resonance-imaging-and-positron-emission-tomography-with-fluorodeoxyglucose-to-diagnose-active-cardiac-sarcoidosis
#10
Marc R Dweck, Ronan Abgral, Maria Giovanna Trivieri, Philip M Robson, Nicolas Karakatsanis, Venkatesh Mani, Anna Palmisano, Marc A Miller, Anuradha Lala, Helena L Chang, Javier Sanz, Johanna Contreras, Jagat Narula, Valentin Fuster, Maria Padilla, Zahi A Fayad, Jason C Kovacic
OBJECTIVES: The purpose of this study was to explore the diagnostic usefulness of hybrid cardiac magnetic resonance (CMR) and positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) for active cardiac sarcoidosis. BACKGROUND: Active cardiac sarcoidosis (aCS) is underdiagnosed and has a high mortality. METHODS: Patients with clinical suspicion of aCS underwent hybrid CMR/PET with late gadolinium enhancement (LGE) and FDG to assess the pattern of injury and disease activity, respectively...
June 9, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28619199/changing-demographics-a-new-approach-to-global-health-care-due-to-the-aging-population
#11
EDITORIAL
Valentin Fuster
No abstract text is available yet for this article.
June 20, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28618914/role-of-the-polypill-for-secondary-prevention-in-ischaemic-heart-disease
#12
José M Castellano, Valentín Fuster, Catriona Jennings, Eva Prescott, Héctor Bueno
In 2011, for the first time in the history of humankind, non-communicable diseases became the leading cause of death worldwide. This change in trend is obviously multifactorial and very complex, as it is the paradoxical result of social, economic and health system growth worldwide. Vaccination and infectious diseases control, changing dietary habits worldwide, sedentary behaviour, globalisation, industrialisation (resulting in a shift from manual to sedentary labour), tobacco and sugary beverage surges in low- and middle-income countries and rapid urbanisation have all played a role in this epidemic transition...
June 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28596216/effect-of-ischemia-duration-and-protective-interventions-on-the-temporal-dynamics-of-tissue-composition-after-myocardial-infarction
#13
Rodrigo Fernández-Jiménez, Carlos Galán-Arriola, Javier Sánchez-González, Jaume Agüero, Gonzalo J López-Martín, Sandra Gomez-Talavera, Jaime Garcia-Prieto, Austin Benn, Antonio Molina-Iracheta, Manuel Barreiro-Pérez, Ana Martin-García, Inés García-Lunar, Gonzalo Pizarro, Javier Sanz, Pedro L Sánchez, Valentin Fuster, Borja Ibanez
RATIONALE: The impact of cardioprotective strategies and ischemia duration on postischemia/reperfusion (I/R) myocardial tissue composition (edema, myocardium at risk, infarct size, salvage, intramyocardial hemorrhage, and microvascular obstruction) is not well understood. OBJECTIVE: To study the effect of ischemia duration and protective interventions on the temporal dynamics of myocardial tissue composition in a translational animal model of I/R by the use of state-of-the-art imaging technology...
August 4, 2017: Circulation Research
https://www.readbyqxmd.com/read/28577673/bridging-income-generation-with-group-integrated-care-for-cardiovascular-risk-reduction-rationale-and-design-of-the-bigpic-study
#14
RANDOMIZED CONTROLLED TRIAL
Rajesh Vedanthan, Jemima H Kamano, Hana Lee, Benjamin Andama, Gerald S Bloomfield, Allison K DeLong, David Edelman, Eric A Finkelstein, Joseph W Hogan, Carol R Horowitz, Simon Manyara, Diana Menya, Violet Naanyu, Sonak D Pastakia, Thomas W Valente, Cleophas C Wanyonyi, Valentin Fuster
BACKGROUND: Cardiovascular disease (CVD) is the leading cause of mortality worldwide, with >80% of CVD deaths occurring in low and middle income countries (LMICs). Diabetes mellitus and pre-diabetes are risk factors for CVD, and CVD is the major cause of morbidity and mortality among individuals with DM. There is a critical period now during which reducing CVD risk among individuals with diabetes and pre-diabetes may have a major impact. Cost-effective, culturally appropriate, and context-specific approaches are required...
June 2017: American Heart Journal
https://www.readbyqxmd.com/read/28575280/global-position-paper-on-cardiovascular-regenerative-medicine-scientific-statement-of-the-transnational-alliance-for-regenerative-therapies-in-cardiovascular-syndromes-tactics-international-group-for-the-comprehensive-cardiovascular-application-of-regenerative
#15
Francisco Fernández-Avilés, Ricardo Sanz-Ruiz, Andreu M Climent, Lina Badimon, Roberto Bolli, Dominique Charron, Valentin Fuster, Stefan Janssens, Jens Kastrup, Hyo-Soo Kim, Thomas F Lüscher, John F Martin, Philippe Menasché, Robert D Simari, Gregg W Stone, Andre Terzic, James T Willerson, Joseph C Wu
No abstract text is available yet for this article.
May 30, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28545641/changing-our-dietary-habits-empathizing-with-sisyphus
#16
EDITORIAL
Valentin Fuster
No abstract text is available yet for this article.
May 30, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28521888/clinical-significance-of-lipid-rich-plaque%C3%A2-detected-by-optical-coherence%C3%A2-tomography-a%C3%A2-4-year-follow-up-study
#17
MULTICENTER STUDY
Lei Xing, Takumi Higuma, Zhao Wang, Aaron D Aguirre, Kyoichi Mizuno, Masamichi Takano, Harold L Dauerman, Seung-Jung Park, Yangsoo Jang, Chong-Jin Kim, Soo-Joong Kim, So-Yeon Choi, Tomonori Itoh, Shiro Uemura, Harry Lowe, Darren L Walters, Peter Barlis, Stephen Lee, Amir Lerman, Catalin Toma, Jack Wei Chieh Tan, Erika Yamamoto, Krzysztof Bryniarski, Jiannan Dai, Thomas Zanchin, Shaosong Zhang, Bo Yu, Hang Lee, James Fujimoto, Valentin Fuster, Ik-Kyung Jang
BACKGROUND: Lipid-rich plaque (LRP) is thought to be a precursor to cardiac events. However, its clinical significance in coronary arteries has never been systematically investigated. OBJECTIVES: This study investigated the prevalence and clinical significance of LRP in the nonculprit region of the target vessel in patients undergoing percutaneous coronary intervention (PCI). METHODS: The study included 1,474 patients from 20 sites across 6 countries undergoing PCI, who had optical coherence tomography (OCT) imaging of the target vessel...
May 23, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28454800/rationale-and-design-of-family-based-approach-in-a-minority-community-integrating-systems-biology-for-promotion-of-health-familia
#18
RANDOMIZED CONTROLLED TRIAL
Sameer Bansilal, Rajesh Vedanthan, Jason C Kovacic, Ana Victoria Soto, Jacqueline Latina, Johan L M Björkegren, Risa Jaslow, Maribel Santana, Samantha Sartori, Chiara Giannarelli, Venkatesh Mani, Roger Hajjar, Eric Schadt, Andrew Kasarskis, Zahi A Fayad, Valentin Fuster
BACKGROUND: The 2020 American Heart Association Impact Goal aims to improve cardiovascular health of all Americans by 20% while reducing deaths from cardiovascular disease and stroke by 20%. A large step toward this goal would be to better understand and take advantage of the significant intersection between behavior and biology across the entire life-span. In the proposed FAMILIA studies, we aim to directly address this major knowledge and clinical health gap by implementing an integrated family-centric health promotion intervention and focusing on the intersection of environment and behavior, while understanding the genetic and biologic basis of cardiovascular disease...
May 2017: American Heart Journal
https://www.readbyqxmd.com/read/28416795/neutrophil-stunning-by-metoprolol-reduces-infarct-size
#19
Jaime García-Prieto, Rocío Villena-Gutiérrez, Mónica Gómez, Esther Bernardo, Andrés Pun-García, Inés García-Lunar, Georgiana Crainiciuc, Rodrigo Fernández-Jiménez, Vinatha Sreeramkumar, Rafael Bourio-Martínez, José M García-Ruiz, Alfonso Serrano Del Valle, David Sanz-Rosa, Gonzalo Pizarro, Antonio Fernández-Ortiz, Andrés Hidalgo, Valentín Fuster, Borja Ibanez
The β1-adrenergic-receptor (ADRB1) antagonist metoprolol reduces infarct size in acute myocardial infarction (AMI) patients. The prevailing view has been that metoprolol acts mainly on cardiomyocytes. Here, we demonstrate that metoprolol reduces reperfusion injury by targeting the haematopoietic compartment. Metoprolol inhibits neutrophil migration in an ADRB1-dependent manner. Metoprolol acts during early phases of neutrophil recruitment by impairing structural and functional rearrangements needed for productive engagement of circulating platelets, resulting in erratic intravascular dynamics and blunted inflammation...
April 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28341414/myocardial-extracellular-volume-is-not-associated-with-malignant-ventricular-arrhythmias-in-high-risk-hypertrophic-cardiomyopathy
#20
Jesús G Mirelis, Javier Sánchez-González, Esther Zorio, Tomas Ripoll-Vera, Rafael Salguero-Bodes, David Filgueiras-Rama, Esther González-López, María Gallego-Delgado, Rodrigo Fernández-Jiménez, María Jesús Soleto, Juana Núñez, Gonzalo Pizarro, Javier Sanz, Valentín Fuster, Pablo García-Pavía, Borja Ibáñez
INTRODUCTION AND OBJECTIVES: Myocardial interstitial fibrosis, a hallmark of hypertrophic cardiomyopathy (HCM), has been proposed as an arrhythmic substrate. Fibrosis is associated with increased extracellular volume (ECV), which can be quantified by computed tomography (CT). We aimed to analyze the association between CT-determined ECV and malignant ventricular arrhythmias. METHODS: A retrospective case-control observational study was conducted in HCM patients with implantable cardioverter-defibrillator, undergoing a CT-protocol with continuous iodine contrast infusion to determine equilibrium ECV...
March 21, 2017: Revista Española de Cardiología
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