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https://www.readbyqxmd.com/read/28061997/evaluation-of-the-pooled-cohort-equations-for-prediction-of-cardiovascular-risk-in-a-contemporary-prospective-cohort
#1
Connor A Emdin, Amit V Khera, Pradeep Natarajan, Derek Klarin, Usman Baber, Roxana Mehran, Daniel J Rader, Valentin Fuster, Sekar Kathiresan
Most guidelines suggest a baseline risk assessment to guide atherosclerotic cardiovascular disease (ASCVD) prevention strategies. The American Heart Association/American College of Cardiology Pooled Cohort Equations (PCEs) is one tool to assess baseline risk; however, the accuracy of this tool has been called into question. We aimed to examine the calibration and discrimination of the PCEs in the BioImage study, a contemporary multiethnic cohort of asymptomatic adults enrolled from 2008 to 2009 in the Humana Health System in Chicago, Illinois, and Fort Lauderdale, Florida...
December 18, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/28057233/a-devotion-to-never-feeling-satisfied-new-jacc-content-avenues
#2
EDITORIAL
Valentin Fuster
No abstract text is available yet for this article.
January 3, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27993926/oxidized-ldl-is-associated-with-metabolic-syndrome-traits-independently-of-central-obesity-and-insulin-resistance
#3
Yamilee Hurtado-Roca, Hector Bueno, Antonio Fernandez-Ortiz, Jose Maria Ordovas, Borja Ibañez, Valentin Fuster, Fernando Rodriguez-Artalejo, Martin Laclaustra
This study assesses whether oxidative stress, using oxidized LDL (ox-LDL) as proxy, is associated with metabolic syndrome (MS), whether ox-LDL mediates the association between central obesity and MS, and whether insulin resistance mediates the association between ox-LDL and MS. We examined baseline data from 3987 non-diabetic subjects in the Progression of Early Subclinical Atherosclerosis (PESA) Study. For the 2nd, 3rd, and 4th ox-LDL quartiles versus the 1st, the odds ratios (95% confidence interval) for MS were 0...
December 19, 2016: Diabetes
https://www.readbyqxmd.com/read/27988210/neuropilin1-regulates-glomerular-function-and-basement-membrane-composition-through-pericytes-in-the-mouse-kidney
#4
Monika Wnuk, Manuel A Anderegg, Werner A Graber, Regula Buergy, Daniel G Fuster, Valentin Djonov
Neuropilin1 (Nrp1) is a co-receptor best known to regulate the development of endothelial cells and is a target of anticancer therapies. However, its role in other vascular cells including pericytes is emergent. The kidney is an organ with high pericyte density and cancer patients develop severe proteinuria following administration of NRP1B-neutralizing antibody combined with bevacizumab. Therefore, we investigated whether Nrp1 regulates glomerular capillary integrity after completion of renal development using two mouse models; tamoxifen-inducible NG2Cre to delete Nrp1 specifically in pericytes and administration of Nrp1-neutralizing antibodies...
December 14, 2016: Kidney International
https://www.readbyqxmd.com/read/27959714/genetic-risk-adherence-to-a-healthy-lifestyle-and-coronary-disease
#5
Amit V Khera, Connor A Emdin, Isabel Drake, Pradeep Natarajan, Alexander G Bick, Nancy R Cook, Daniel I Chasman, Usman Baber, Roxana Mehran, Daniel J Rader, Valentin Fuster, Eric Boerwinkle, Olle Melander, Marju Orho-Melander, Paul M Ridker, Sekar Kathiresan
Background Both genetic and lifestyle factors contribute to individual-level risk of coronary artery disease. The extent to which increased genetic risk can be offset by a healthy lifestyle is unknown. Methods Using a polygenic score of DNA sequence polymorphisms, we quantified genetic risk for coronary artery disease in three prospective cohorts - 7814 participants in the Atherosclerosis Risk in Communities (ARIC) study, 21,222 in the Women's Genome Health Study (WGHS), and 22,389 in the Malmö Diet and Cancer Study (MDCS) - and in 4260 participants in the cross-sectional BioImage Study for whom genotype and covariate data were available...
15, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/27938844/little-beacons-of-change-targeting-preschool-children-to-drive-a-culture-of-health
#6
EDITORIAL
Jacqueline Latina, Sameer Bansilal, Rajesh Vedanthan, Valentin Fuster
No abstract text is available yet for this article.
December 2016: Global Heart
https://www.readbyqxmd.com/read/27938821/cardiovascular-diseases-on-the-global-agenda-the-united-nations-high-level-meeting-sustainable-development-goals-and-the-way-forward
#7
REVIEW
Johanna Ralston, K Srinath Reddy, Valentin Fuster, Jagat Narula
In 2011, the United Nations (UN) organized the first ever meeting for heads of state to discuss the problem of noncommunicable diseases (NCD), including cardiovascular disease (CVD), cancer, chronic respiratory disease, and diabetes mellitus. Recognizing that these had emerged as leading causes of morbidity and mortality in the world, including in many low- and middle-income countries, advocates from government and civil society had called for increased attention and a UN response. Earlier, NCD including CVD were absent from the global health agenda in part because of their omission from the Millennium Development Goals...
December 2016: Global Heart
https://www.readbyqxmd.com/read/27908353/the-risk-continuum-of-atherosclerosis-and%C3%A2-its-implications-for-defining-chd-by%C3%A2-coronary-angiography
#8
REVIEW
Armin Arbab-Zadeh, Valentin Fuster
Patients undergoing coronary angiography for suspected coronary heart disease who are found to have coronary atherosclerotic disease with <50% diameter stenosis may carry a risk of adverse cardiac events similar to that in patients with single-vessel obstructive disease. Yet clinical practice guidelines offer no direction for managing symptomatic patients with nonobstructive coronary atherosclerosis because current diagnostic criteria for coronary heart disease are not met. Accordingly, secondary preventive measures are not endorsed, and their role is not defined in this setting...
December 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27888762/nutritional-preconditioning-by-marine-omega-3-fatty-acids-in-patients-with-st-segment-elevation-myocardial-infarction-a-metocard-cnic-trial-substudy
#9
Aleix Sala-Vila, Rodrigo Fernández-Jiménez, Gonzalo Pizarro, Carlos Calvo, Jose M García-Ruiz, Leticia Fernández-Friera, Maite D Rodriguez, Noemí Escalera, Jorge Palazuelos, Angel Macías, Braulio Pérez-Asenjo, Antonio Fernández-Ortiz, Emilio Ros, Valentín Fuster, Borja Ibáñez
No abstract text is available yet for this article.
February 1, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/27886793/innovative-approaches-to-hypertension-control-in-low-and-middle-income-countries
#10
REVIEW
Rajesh Vedanthan, Antonio Bernabe-Ortiz, Omarys I Herasme, Rohina Joshi, Patricio Lopez-Jaramillo, Amanda G Thrift, Jacqui Webster, Ruth Webster, Karen Yeates, Joyce Gyamfi, Merina Ieremia, Claire Johnson, Jemima H Kamano, Maria Lazo-Porras, Felix Limbani, Peter Liu, Tara McCready, J Jaime Miranda, Sailesh Mohan, Olugbenga Ogedegbe, Brian Oldenburg, Bruce Ovbiagele, Mayowa Owolabi, David Peiris, Vilarmina Ponce-Lucero, Devarsetty Praveen, Arti Pillay, Jon-David Schwalm, Sheldon W Tobe, Kathy Trieu, Khalid Yusoff, Valentin Fuster
Elevated blood pressure, a major risk factor for ischemic heart disease, heart failure, and stroke, is the leading global risk for mortality. Treatment and control rates are very low in low- and middle-income countries. There is an urgent need to address this problem. The Global Alliance for Chronic Diseases sponsored research projects focus on controlling hypertension, including community engagement, salt reduction, salt substitution, task redistribution, mHealth, and fixed-dose combination therapies. This paper reviews the rationale for each approach and summarizes the experience of some of the research teams...
February 2017: Cardiology Clinics
https://www.readbyqxmd.com/read/27872105/multiethnic-exome-wide-association-study-of-subclinical-atherosclerosis
#11
Pradeep Natarajan, Joshua C Bis, Lawrence F Bielak, Amanda J Cox, Marcus Dörr, Mary F Feitosa, Nora Franceschini, Xiuqing Guo, Shih-Jen Hwang, Aaron Isaacs, Min A Jhun, Maryam Kavousi, Ruifang Li-Gao, Leo-Pekka Lyytikäinen, Riccardo E Marioni, Ulf Schminke, Nathan O Stitziel, Hayato Tada, Jessica van Setten, Albert V Smith, Dina Vojinovic, Lisa R Yanek, Jie Yao, Laura M Yerges-Armstrong, Najaf Amin, Usman Baber, Ingrid B Borecki, J Jeffrey Carr, Yii-Der Ida Chen, L Adrienne Cupples, Pim A de Jong, Harry de Koning, Bob D de Vos, Ayse Demirkan, Valentin Fuster, Oscar H Franco, Mark O Goodarzi, Tamara B Harris, Susan R Heckbert, Gerardo Heiss, Udo Hoffmann, Albert Hofman, Ivana Išgum, J Wouter Jukema, Mika Kähönen, Sharon L R Kardia, Brian G Kral, Lenore J Launer, Joe Massaro, Roxana Mehran, Braxton D Mitchell, Thomas H Mosley, Renée de Mutsert, Anne B Newman, Khanh-Dung Nguyen, Kari E North, Jeffrey R O'Connell, Matthijs Oudkerk, James S Pankow, Gina M Peloso, Wendy Post, Michael A Province, Laura M Raffield, Olli T Raitakari, Dermot F Reilly, Fernando Rivadeneira, Frits Rosendaal, Samantha Sartori, Kent D Taylor, Alexander Teumer, Stella Trompet, Stephen T Turner, Andre G Uitterlinden, Dhananjay Vaidya, Aad van der Lugt, Uwe Völker, Joanna M Wardlaw, Christina L Wassel, Stefan Weiss, Mary K Wojczynski, Diane M Becker, Lewis C Becker, Eric Boerwinkle, Donald W Bowden, Ian J Deary, Abbas Dehghan, Stephan B Felix, Vilmundur Gudnason, Terho Lehtimäki, Rasika Mathias, Dennis O Mook-Kanamori, Bruce M Psaty, Daniel J Rader, Jerome I Rotter, James G Wilson, Cornelia M van Duijn, Henry Völzke, Sekar Kathiresan, Patricia A Peyser, Christopher J O'Donnell
BACKGROUND: The burden of subclinical atherosclerosis in asymptomatic individuals is heritable and associated with elevated risk of developing clinical coronary heart disease. We sought to identify genetic variants in protein-coding regions associated with subclinical atherosclerosis and the risk of subsequent coronary heart disease. METHODS AND RESULTS: We studied a total of 25 109 European ancestry and African ancestry participants with coronary artery calcification (CAC) measured by cardiac computed tomography and 52 869 participants with common carotid intima-media thickness measured by ultrasonography within the CHARGE Consortium (Cohorts for Heart and Aging Research in Genomic Epidemiology)...
December 2016: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/27816118/relation-of-post-coronary-artery-bypass-graft-creatine-kinase-mb-elevations-and-new-q-waves-with-long-term-cardiovascular-death-in-patients-with-diabetes-mellitus-and-multivessel-coronary-artery-disease
#12
Michael Domanski, Michael E Farkouh, Victor Zak, John French, John H Alexander, Andrzej Bochenek, Martial Hamon, Kenneth Mahaffey, John Puskas, Peter Smith, Peter Shrader, Valentin Fuster
Associations of early creatine phosphokinase-MB (CK-MB) elevation and new Q waves and their association with cardiovascular death (CVD) after coronary artery bypass grafting (CABG) have been reported, but this association has not been studied in a large population of patients with diabetes mellitus. In this study, we examine the association of periprocedural CK-MB elevations and new Q waves with CVD in the Future Revascularization Evaluation in Patients with Diabetes Mellitus: Optimal Management of Multivessel Disease trial...
August 30, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27793511/cultural-third-world-war-how-economic-disparity-adversely%C3%A2-affects%C3%A2-health
#13
EDITORIAL
Valentin Fuster
No abstract text is available yet for this article.
October 26, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27712639/antithrombotic-approaches-in-acute-coronary-syndromes-optimizing-benefit-vs-bleeding-risks
#14
REVIEW
Mandeep Singh, Deepak L Bhatt, Gregg W Stone, Charanjit S Rihal, Bernard J Gersh, Ryan J Lennon, Jagat Narula, Valentin Fuster
It is estimated that in the United States, each year, approximately 620,000 persons will experience an acute coronary syndrome and approximately 70% of these will have non-ST-elevation acute coronary syndrome. Cardiovascular disease still accounts for 1 of every 3 deaths in the United States, and there is an urgent need to improve the prognosis of patients presenting with acute coronary syndrome. Cardiovascular mortality and ischemic complications are common after acute coronary syndrome, and the advent of newer antithrombotic therapies has reduced ischemic complications, but at the expense of greater bleeding...
October 2016: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/27635081/the-cnic-a-successful-vision-in-cardiovascular-research
#15
Valentín Fuster, Borja Ibáñez, Vicente Andrés
No abstract text is available yet for this article.
September 16, 2016: Circulation Research
https://www.readbyqxmd.com/read/27601365/magnetic-resonance-characterization-of-cardiac-adaptation-and-myocardial-fibrosis-in-pulmonary-hypertension-secondary-to-systemic-to-pulmonary-shunt
#16
Daniel Pereda, Inés García-Lunar, Federico Sierra, Damián Sánchez-Quintana, Evelyn Santiago, Constanza Ballesteros, Juan F Encalada, Javier Sánchez-González, Valentín Fuster, Borja Ibáñez, Ana García-Álvarez
BACKGROUND: Pulmonary hypertension (PH) and right ventricular (RV) dysfunction are strong predictors of morbidity and mortality among patients with congenital heart disease. Early detection of RV involvement may be useful in the management of these patients. We aimed to assess progressive cardiac adaptation and quantify myocardial extracellular volume in an experimental porcine model of PH because of aorto-pulmonary shunt using cardiac magnetic resonance (CMR). METHODS AND RESULTS: To characterize serial cardiac adaptation, 12 pigs (aorto-pulmonary shunt [n=6] or sham operation [n=6]) were evaluated monthly with right heart catheterization, CMR, and computed tomography during 4 months, followed by pathology analysis...
September 2016: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/27592277/accuracy-of-area-at-risk-quantification-by-cardiac-magnetic-resonance-according-to-the-myocardial-infarction-territory
#17
Leticia Fernández-Friera, José Manuel García-Ruiz, Ana García-Álvarez, Rodrigo Fernández-Jiménez, Javier Sánchez-González, Xavier Rossello, Sandra Gómez-Talavera, Gonzalo J López-Martín, Gonzalo Pizarro, Valentín Fuster, Borja Ibáñez
INTRODUCTION AND OBJECTIVES: Area at risk (AAR) quantification is important to evaluate the efficacy of cardioprotective therapies. However, postinfarction AAR assessment could be influenced by the infarcted coronary territory. Our aim was to determine the accuracy of T2-weighted short tau triple-inversion recovery (T2W-STIR) cardiac magnetic resonance (CMR) imaging for accurate AAR quantification in anterior, lateral, and inferior myocardial infarctions. METHODS: Acute reperfused myocardial infarction was experimentally induced in 12 pigs, with 40-minute occlusion of the left anterior descending (n = 4), left circumflex (n = 4), and right coronary arteries (n = 4)...
August 31, 2016: Revista Española de Cardiología
https://www.readbyqxmd.com/read/27585501/medical-treatment-and-revascularization-options-in-patients-with-type-2-diabetes-and-coronary-disease
#18
G B John Mancini, Michael E Farkouh, Maria M Brooks, Bernard R Chaitman, William E Boden, Helen Vlachos, Pamela M Hartigan, Flora S Siami, Mandeep S Sidhu, Vera Bittner, Robert Frye, Valentin Fuster
BACKGROUND: There are scant outcomes data in patients with type 2 diabetes and stable coronary artery disease (CAD) stratified by detailed angiographic burden of CAD or left ventricular ejection fraction (LVEF). OBJECTIVES: This study determined the effect of optimal medical therapy (OMT), with or without percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), on long-term outcomes with respect to LVEF and number of diseased vessels, including proximal left anterior descending artery involvement...
September 6, 2016: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/27572072/comparative-efficacy-of-coronary-artery-bypass-surgery-vs-percutaneous-coronary-intervention-in-patients-with-diabetes-and-multivessel-coronary-artery-disease-with-or-without-chronic-kidney-disease
#19
Usman Baber, Michael E Farkouh, Yaron Arbel, Paul Muntner, George Dangas, Michael J Mack, Taye H Hamza, Roxana Mehran, Valentin Fuster
BACKGROUND: The optimal method of coronary revascularization among patients with diabetes mellitus (DM) and multivessel coronary artery disease (CAD) complicated by chronic kidney disease (CKD) remains unknown. PURPOSE: To examine the impact of coronary artery bypass surgery (CABG) vs. percutaneous coronary intervention (PCI) on cardiovascular outcomes in patients with diabetes with and without CKD. METHODS: We conducted an 'as-treated' subgroup analysis of the FREEDOM trial to examine the therapeutic efficacy of CABG vs...
December 7, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27561760/a-simple-disease-guided-approach-to-personalize-acc-aha-recommended-statin%C3%A2-allocation-in-elderly-people-the-bioimage-study
#20
Martin Bødtker Mortensen, Valentin Fuster, Pieter Muntendam, Roxana Mehran, Usman Baber, Samantha Sartori, Erling Falk
BACKGROUND: The 2013 American College of Cardiology (ACC)/American Heart Association (AHA) guidelines recommend primary prevention with statins for individuals with ≥7.5% 10-year risk for atherosclerotic cardiovascular disease (ASCVD). Everyone living long enough will become eligible for risk-based statin therapy due to age alone. OBJECTIVES: This study sought to personalize ACC/AHA risk-based statin eligibility using noninvasive assessment of subclinical atherosclerosis...
August 30, 2016: Journal of the American College of Cardiology
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