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https://www.readbyqxmd.com/read/27871281/physical-multimorbidity-and-psychosis-comprehensive-cross-sectional-analysis-including-242-952-people-across-48-low-and-middle-income-countries
#1
Brendon Stubbs, Ai Koyanagi, Nicola Veronese, Davy Vancampfort, Marco Solmi, Fiona Gaughran, André F Carvalho, John Lally, Alex J Mitchell, James Mugisha, Christoph U Correll
BACKGROUND: In people with psychosis, physical comorbidities, including cardiovascular and metabolic diseases, are highly prevalent and leading contributors to the premature mortality encountered. However, little is known about physical health multimorbidity in this population or in people with subclinical psychosis and in low- and middle-income countries (LMICs). This study explores physical health multimorbidity patterns among people with psychosis or subclinical psychosis. METHODS: Overall, data from 242,952 individuals from 48 LMICs, recruited via the World Health Survey, were included in this cross-sectional study...
November 22, 2016: BMC Medicine
https://www.readbyqxmd.com/read/27814579/the-emergence-of-aspergillus-species-in-chronic-respiratory-disease
#2
Anthony Ca Yii, Mariko S Koh, Therese S Lapperre, Gan L Tan, Sanjay H Chotirmall
Chronic lung disease is recognized as an important risk factor for developing pulmonary aspergillosis. The development of specific aspergillus-associated syndromes depends on host immunity and underlying lung disease. In the setting of asthma, hypersensitivity to Aspergillus can lead to allergic bronchopulmonary aspergillosis (ABPA) or severe asthma with fungal sensitization (SAFS). Chronic use of systemic or inhaled corticosteroids coupled with recurrent antibiotic use for exacerbations prevalent in chronic obstructive pulmonary disease (COPD) predisposes to chronic pulmonary aspergillosis (CPA)...
January 1, 2017: Frontiers in Bioscience (Scholar Edition)
https://www.readbyqxmd.com/read/27806533/epidemiologic-correlates-of-chronic-respiratory-infections-in-adults-an-urban-slum-of-bhubaneswar-odisha-india
#3
Sonali Kar, Ipsa Mohapatra, Amrita Konar
INTRODUCTION: Urbanization is marked by emergence of slum areas, wherein migrants from the nearby villages stay in temporary establishments for seeking avenues of employment. These dwellings lack most of the essential living conditions like safe water, healthy living conditions and access to health services. This population is also vulnerable to social evils like alcohol and tobacco addiction. KIMS, a medical college in Bhubaneswar, Odisha, India has an Urban Health Training Centre (UHTC) that caters to a slum population of nearly 12,000 population for their primary health needs...
August 4, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27789254/estimating-the-burden-of-invasive-and-serious-fungal-disease-in-the-united-kingdom
#4
Matthew Pegorie, David W Denning, William Welfare
BACKGROUND: The burden of fungal disease in the UK is unknown. Only limited data are systematically collected. We have estimated the annual burden of invasive and serious fungal disease. METHODS: We used several estimation approaches. We searched and assessed published estimates of incidence, prevalence or burden of specific conditions in various high risk groups. Studies with adequate internal and external validity allowed extrapolation to estimate current UK burden...
October 24, 2016: Journal of Infection
https://www.readbyqxmd.com/read/27787715/bifunctional-drugs-for-the-treatment-of-respiratory-diseases
#5
Clive Page, Mario Cazzola
Over the last decade, there has been a steady increase in the use of fixed dose combinations for the treatment of a range of diseases, including cancer, AIDS, tuberculosis and other infectious diseases. It is now evident that patients with asthma or chronic obstructive pulmonary disease (COPD) can also benefit from the use of fixed dose combinations, including combinations of a long-acting β2-agonist (LABA) and an inhaled corticosteroid (ICS), and combinations of LABAs and long-acting muscarinic receptor antagonists (LAMAs)...
October 28, 2016: Handbook of Experimental Pharmacology
https://www.readbyqxmd.com/read/27773800/in-vitro-and-in-vivo-antimycobacterial-hepatoprotective-and-immunomodulatory-activity-of-euclea-natalensis-and-its-mode-of-action
#6
Namrita Lall, Vivek Kumar, Debra Meyer, Nomasomi Gasa, Chris Hamilton, Motlalepula Matsabisa, Carel Oosthuizen
ETHNOPHARMACOLOGICAL RELEVANCE: The Natal gwarri or Natal ebony (Euclea natalensis A.DC.) is a deciduous tree found widespread throughout southern Africa, especially in Kwazulu-Natal and the southern cost. It has been widely used by indigenous communities such as the Zulus, Tsongas and Vendas for symptoms related to tuberculosis (TB). The decoctions made from the plant parts are administered for chest diseases to treat complications such as chest pains, bronchitis, pleurisy and asthma...
October 20, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27761428/effects-of-flavonoids-from-martynia-annua-and-tephrosia-purpurea-on-cutaneous-wound-healing
#7
Santram Lodhi, Avijeet Jain, Alok Pal Jain, Rajesh Singh Pawar, Abhay Kumar Singhai
OBJECTIVE: Martynia annua L. (M. annua), (Martyniaccae) has been traditionally used in the treatment of epilepsy, sore throat and inflammatory disorders. The leaf paste is used topically on Tuberculosis of the lymphatic glands and wounds of domestic animals. Tephrosia purpurea (T. purpurea), (Fabaceae) has been used traditionally as a remedy for asthma, gonorrhea, rheumatism and ulcers. This study aimed to evaluate the potential wound healing effects of different fractions ofethanol extract of M...
September 2016: Avicenna Journal of Phytomedicine
https://www.readbyqxmd.com/read/27725053/primary-care-physicians-ability-to-diagnose-the-most-prevalent-respiratory-diseases
#8
B P de São José, P A M Camargos, E D Bateman, C M A Botelho, J G F de Seixas Maciel, E V Mancuzo, R de Amorim Corrêa
BACKGROUND: There are few reports on the ability of primary care physicians (PCPs) to diagnose acute and chronic respiratory diseases. We assessed the agreement between PCPs and pulmonologists in diagnosing pulmonary tuberculosis (TB), chronic obstructive pulmonary disease (COPD), asthma and acute respiratory infections (ARI). SETTING: Metropolitan Region of Belo Horizonte, State of Minas Gerais, Brazil. METHODS: PCPs filled out a symptom-based questionnaire for adult patients presenting with respiratory symptoms...
October 2016: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/27720448/risk-factors-associated-with-hospitalisation-for-influenza-associated-severe-acute-respiratory-illness-in-south-africa-a-case-population-study
#9
Tochukwu Raphael Abadom, Adrian D Smith, Stefano Tempia, Shabir A Madhi, Cheryl Cohen, Adam L Cohen
BACKGROUND: Influenza is a common cause of severe respiratory illness, but risk factors for hospitalisation in low income settings with a high HIV prevalence are not well described. We aimed to assess risk factors associated with influenza-associated severe acute respiratory illness (SARI) hospitalisation in South Africa. METHODS: We conducted a case-population study using data on risk conditions in patients hospitalised with SARI and the national prevalence of these conditions...
October 6, 2016: Vaccine
https://www.readbyqxmd.com/read/27631224/prognostic-effect-of-tuberculosis-on-patients-with-occupational-lung-diseases-a-13-year-observational-study-in-a-nationwide-cohort
#10
Chung-Lin Hung, Po-Lan Su, Chih-Ying Ou
Occupational lung diseases are well recognized risk factors for tuberculosis (TB). However, little research investigated the effect of TB on the clinical course and outcome of occupational lung diseases.We conducted a 13-year observational study of a nationwide cohort to evaluate the risk and prognosis of TB among patients with occupational lung diseases in Taiwan.By using the Taiwan National Health Insurance database, occupational lung diseases cohort was identified according to diagnosis codes from 1998 to 2008 and prospectively monitored until the end of 2010, loss to follow-up, or death...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27609056/the-double-burden-of-disease-among-mining-workers-in-papua-indonesia-at-the-crossroads-between-old-and-new-health-paradigms
#11
Rodrigo Rodriguez-Fernandez, Nawi Ng, Dwidjo Susilo, John Prawira, Michael J Bangs, Rachel M Amiya
BACKGROUND: As the global shift toward non-communicable diseases overlaps with the unfinished agenda of confronting infectious diseases in low- and middle-income countries, epidemiological links across both burdens must be recognized. This study examined the non-communicable disease-infectious disease overlap in the specific comorbidity rates for key diseases in an occupational cohort in Papua, Indonesia. METHODS: Diagnosed cases of ischaemic heart disease, stroke, hypertension, diabetes (types 1 and 2), chronic obstructive pulmonary disease, asthma, cancer, HIV and AIDS, tuberculosis, and malaria were extracted from 22,550 patient records (21,513 men, 1037 women) stored in identical electronic health information systems from two clinic sites in Papua, Indonesia...
2016: BMC Public Health
https://www.readbyqxmd.com/read/27599605/plant-based-vaccines-against-respiratory-diseases-current-status-and-future-prospects
#12
Verónica A Márquez-Escobar, Sergio Rosales-Mendoza, Josué I Beltrán-López, Omar González-Ortega
INTRODUCTION: Respiratory infections have an enormous, worldwide epidemiologic impact on humans and animals. Among the prophylactic measures, vaccination has the potential to neutralize this impact. New technologies for vaccine production and delivery are of importance in this field since they offer the potential to develop new immunization approaches overriding the current limitations that comprise high cost, safety issues, and limited efficacy. AREAS COVERED: In the present review, the state of the art in developing plant-based vaccines against respiratory diseases is presented...
September 6, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27580321/estimated-burden-of-fungal-infections-in-kenya
#13
John Abuga Guto, Christine C Bii, David W Denning
INTRODUCTION: Kenya is a developing country with a high rate of tuberculosis (TB) and a moderate HIV infection burden. No estimate of the burden of fungal diseases in Kenya is published. METHODOLOGY: We used specific populations at risk and fungal infection frequencies from the literature to estimate national incidence or prevalence of serious fungal infections. Used sources were: 2010 WHO TB statistics, Kenya Acquired Immunodeficiency Syndrome (AIDS) Epidemic Update 2012, Kenya Facts and figures 2012, Kenya Demographic and Health Survey 2008-2009...
August 31, 2016: Journal of Infection in Developing Countries
https://www.readbyqxmd.com/read/27574522/neutrophil-extracellular-traps-in-pulmonary-diseases-too-much-of-a-good-thing
#14
REVIEW
Bárbara Nery Porto, Renato Tetelbom Stein
Neutrophil extracellular traps (NETs) arise from the release of granular and nuclear contents of neutrophils in the extracellular space in response to different classes of microorganisms, soluble factors, and host molecules. NETs are composed by decondensed chromatin fibers coated with antimicrobial granular and cytoplasmic proteins, such as myeloperoxidase, neutrophil elastase (NE), and α-defensins. Besides being expressed on NET fibers, NE and MPO also regulate NET formation. Furthermore, histone deimination by peptidylarginine deiminase 4 (PAD4) is a central step to NET formation...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27462698/effects-of-quail-egg-on-kidney-functions-in-alloxan-induced-diabetic-wistar-rats
#15
E O Adewoye, T E Adekeye, A O Ige
UNLABELLED: Abstract INTRODUCTION: Uncontrolled diabetes mellitus has been reported to lead to renal dysfunction. Quail egg consumption has been reported to exert curative effects in some disease conditions like diabetes mellitus, tuberculosis, and asthma. This study investigated the effects of quail egg consumption on some kidney functions in alloxan induced diabetic rats. METHODS: Forty male Wistar rats with an average weight of 170g were randomly divided into four groups...
December 2015: African Journal of Medicine and Medical Sciences
https://www.readbyqxmd.com/read/27448321/post-inhaled-corticosteroid-pulmonary-tuberculosis-increases-lung-cancer-in-patients-with-asthma
#16
Zhi-Hong Jian, Jing-Yang Huang, Frank Cheau-Feng Lin, Oswald Ndi Nfor, Kai-Ming Jhang, Wen-Yuan Ku, Chien-Chang Ho, Chia-Chi Lung, Hui-Hsien Pan, Min-Chen Wu, Ming-Fang Wu, Yung-Po Liaw
PURPOSE: To evaluate the association between post-inhaled corticosteroid (ICS) pulmonary tuberculosis (TB), pneumonia and lung cancer in patients with asthma. METHODS: The study samples were collected from the National Health Insurance Database. Asthmatic patients who were first-time users of ICS between 2003 and 2005 were identified as cases. For each case, 4 control individuals were randomly matched for sex, age and date of ICS use. Cases and matched controls were followed up until the end of 2010...
2016: PloS One
https://www.readbyqxmd.com/read/27448309/asthma-chronic-obstructive-pulmonary-diseases-overlap-syndrome-increases-the-risk-of-incident-tuberculosis-a-national-cohort-study
#17
Jun-Jun Yeh, Yu-Chiao Wang, Chia-Hung Kao
PURPOSE: The association between asthma-chronic obstructive pulmonary diseases (COPD) overlap syndrome (ACOS) and tuberculosis (TB) has yet to be studied. METHODS: The newly diagnosed TB patients (age > 20 y) treated from January 2000 to December 2008 were included (ACOS cohort, n = 10 751; non-ACOS cohort, n = 42 966). The non-ACOS cohort involved patients with confirmed absence of ACOS. We calculated incidence rate ratios (IRRs) for TB in the ACOS and non-ACOS cohorts by using poisson regression analysis...
2016: PloS One
https://www.readbyqxmd.com/read/27433170/korean-asthma-guideline-2014-summary-of-major-updates-to-the-korean-asthma-guideline-2014
#18
REVIEW
Deog Kyeom Kim, Yong Bum Park, Yeon-Mok Oh, Ki-Suck Jung, Ji Hong Yoo, Kwang-Ha Yoo, Kwan Hyung Kim
Asthma is a prevalent and serious health problem in Korea. Recently, the Korean Asthma Guideline has been updated by The Korean Academy of Tuberculosis and Respiratory Diseases (KATRD) in an effort to improve the clinical management of asthma. This guideline focuses on adult patients with asthma and aims to deliver up to date scientific evidence and recommendations to general physicians for the management of asthma. For this purpose, this guideline was updated following systematic review and meta-analysis of recent studies and adapting some points of international guidelines (Global Initiative for Asthma [GINA] report 2014, National Asthma Education and Prevention Program [NAEPP] 2007, British Thoracic Society [BTS/SIGN] asthma guideline 2012, and Canadian asthma guideline 2012)...
July 2016: Tuberculosis and Respiratory Diseases
https://www.readbyqxmd.com/read/27368009/retrospective-cohort-evaluation-on-risk-of-pneumonia-in-patients-with-pulmonary-tuberculosis
#19
Tsui-Ming Chang, Chih-Hsin Mou, Te-Chun Shen, Chien-Lung Yang, Min-Hui Yang, Fang-Yang Wu, Fung-Chang Sung
Pulmonary tuberculosis (PTb) and pneumonia are diseases that may exist concomitantly. Population study investigating the subsequent pneumonia development in PTb patients is limited. This study compares the risk of pneumonia between cohorts with and without PTb.We used the claims data of the Taiwan National Health Insurance to identify a cohort with PTb (N = 3417) newly diagnosed in 2000-2006 without pneumonia history, and a randomly selected comparison cohort (N = 6834) free of PTb and pneumonia, frequency matched by propensity score...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27336790/phenotyping-adults-with-non-cystic-fibrosis-bronchiectasis-a-10-year-cohort-study-in-a-french-regional-university-hospital-center
#20
Matthieu Buscot, Héloïse Pottier, Charles-Hugo Marquette, Sylvie Leroy
BACKGROUND: Data concerning phenotypes in bronchiectasis are scarce. OBJECTIVE: The aim of this study was to describe the clinical, functional and microbiological phenotypes of patients with bronchiectasis. METHODS: A monocentric retrospective study in a university hospital in France was conducted over 10 years (2002-2012). Non-cystic fibrosis patients with tomographic confirmation of bronchiectasis were included. The clinical, functional and microbiological data of patients were analyzed relying on the underlying etiology...
2016: Respiration; International Review of Thoracic Diseases
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