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https://www.readbyqxmd.com/read/29908353/the-impact-of-prenatal-diagnosis-on-congenital-anomaly-outcomes-data-from-1997-to-2016
#1
REVIEW
Paula Braz, Ausenda Machado, Carlos Matias Dias
The term prenatal diagnosis comprises a variety of techniques aimed to determine the health and condition of the embryo or foetus. Its main goal is to identify at an early stage of the pregnancy, if possible, malformations or other conditions that could increase the risk of a negative outcome in the pregnancy. The aim of this study was to assess the impact of prenatal diagnosis in Portugal in pregnancies with congenital anomalies. A cross sectional study was implemented using data for the years 1997-2016 from the Portuguese registry of congenital anomalies (RENAC), a population-based registry that follows EUROCAT guidelines...
June 13, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29908231/haploidentical-bone-marrow-transplantation-with-post-transplant-cyclophosphamide-bendamustine-in-pediatric-and-young-adult-patients-with-hematologic-malignancies
#2
Emmanuel Katsanis, Lauren N Sapp, Nicole Varner, Shannon Koza, Baldassarre Stea, Yi Zeng
More than half of patients undergoing hematopoietic cell transplantation at our institution are ethnic or racial minorities, making the search for matched unrelated donors more challenging. Since the introduction of haploidentical bone marrow transplant (haplo-BMT) into our pediatric BMT program in 2015, 69.2% of the recipients have been minorities. Herein, we describe our experience with the first thirteen pediatric and young adult patients with hematologic malignancies who have undergone T-cell replete haplo-BMT following myeloablative conditioning (MAC) at our institution...
June 13, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29908103/prevalence-of-human-respiratory-syncytial-virus-infection-in-people-with-acute-respiratory-tract-infections-in-africa-a-systematic-review-and-meta-analysis
#3
Sebastien Kenmoe, Jean Joel Bigna, Estelle Amandine Well, Fredy Brice N Simo, Véronique B Penlap, Astrid Vabret, Richard Njouom
AIM: The epidemiology of Human Respiratory Syncytial virus (HRSV) infection has not yet been systematically investigated in Africa. This systematic review and meta-analysis is to estimate the prevalence of HRSV infections in people with acute respiratory tract infections (ARTI) in Africa. METHOD: We searched PubMed, EMBASE, Africa Journal Online, and Global Index Medicus to identify observational studies published from Jan 1, 2000 to Aug 1, 2017. We used a random-effects model to estimate the prevalence across studies...
June 16, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29908039/no-neurodevelopmental-benefit-of-cerebral-oximetry-in-the-first-randomised-trial-in-preterm-infants-during-the-first-days-of-life-safeboosc-ii
#4
Anne M Plomgaard, Thomas Alderliesten, Frank van Bel, Manon Benders, Olivier Claris, Malaika Cordeiro, Eugene Dempsey, Monica Fumagalli, Christian Gluud, Simon Hyttel-Sorensen, Petra Lemmers, Adelina Pellicer, Gerhard Pichler, Gorm Greisen
AIM: Cerebral hypoxia has been associated with neurodevelopmental impairment. We studied whether reducing cerebral hypoxia in extremely preterm infants during the first 72 hours of life affected neurological outcomes at two years of corrected age. METHODS: In 2012-2013 the phase II randomised Safeguarding the Brains of our Smallest Children trial compared visible cerebral near infrared spectroscopy (NIRS) monitoring in an intervention group and blinded NIRS monitoring in a control group...
June 16, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29908035/relationship-between-tongue-pressure-and-maxillofacial-morphology-in-japanese-children-based-on-skeletal-classification
#5
Hiroyuki Kurabeishi, Ryu Tatsuo, Nezu Makoto, Fukui Kazunori
BACKGROUND: During childhood, perioral muscle function is closely associated with malocclusion. OBJECTIVE: To clarify effects of tongue function on maxillofacial morphology in children, tongue pressure and maximum lip-closing force (LCF) were measured and the relationship between perioral muscle function and maxillofacial morphology were evaluated according to skeletal classification. METHODS: Maximum tongue pressure (MTP) and swallowing tongue pressure (STP) were measured on the anterior palatine rugae in 100 children (Hellman's dental stages IIIA-IIIC) using a balloon-type tongue-pressure-measurement device...
June 16, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29908025/seroprevalence-and-social-determinants-of-varicella-in-turkey
#6
Can Hüseyin Hekimoğlu, Özgen Alpay Özbek, Mestan Emek, Mehmet Ali Öktem, Galip Köroğlu, Mustafa Sertel, Sevin Özdeniz, Ali Ceylan, Ayla Açikgöz, Belgin Ünal
Background: In Turkey, varicella vaccine was introduced into routine childhood immunization in 2013, with a single dose administered to children aged 12 months. However, there is limited information on the morbidity (incidence and seroprevalence), mortality and burden of disease of varicella in the overall Turkish population. Aim: To determine varicella seroprevalence and its social determinants in Manisa Province, Turkey in children aged > 2 years before single-dose varicella vaccination was introduced in 2013...
June 10, 2018: Eastern Mediterranean Health Journal, la Revue de Santé de la Méditerranée Orientale
https://www.readbyqxmd.com/read/29908001/easy-words-reference-resolution-in-a-malevolent-referent-world
#7
Lila R Gleitman, John C Trueswell
This article describes early stages in the acquisition of a first vocabulary by infants and young children. It distinguishes two major stages, the first of which operates by a stand-alone word-to-world pairing procedure and the second of which, using the evidence so acquired, builds a domain-specific syntax-sensitive structure-to-world pairing procedure. As we show, the first stage of learning is slow, restricted in character, and to some extent errorful, whereas the second procedure is determinative, rapid, and essentially errorless...
June 15, 2018: Topics in Cognitive Science
https://www.readbyqxmd.com/read/29907917/neurologic-consequences-of-preterm-birth
#8
REVIEW
Margie A Ream, Lenora Lehwald
PURPOSE OF REVIEW: Preterm birth is the leading cause of death worldwide in children < 5 years of age; however, technology and advances in medical knowledge are increasing the survival of children born even at the fringes of viability. With increased survival comes increased risk of long-term neurologic impairments. This paper aims to review recent findings related to changes in brain development associated with prematurity and its impact on neurodevelopmental disabilities. RECENT FINDINGS: Advanced imaging techniques, longitudinal follow-up of individuals born extremely preterm into adulthood and improved understanding of risk factors associated with neurologic impairment contribute to recent discoveries...
June 16, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29907863/attenuation-of-retinal-vascular-development-in-neonatal-mice-subjected-to-hypoxic-ischemic-encephalopathy
#9
Ismail S Zaitoun, Ulas Cikla, Dila Zafer, Eshwar Udho, Reem Almomani, Andrew Suscha, Pelin Cengiz, Christine M Sorenson, Nader Sheibani
A significant proportion of children that survive hypoxic-ischemic encephalopathy (HIE) develop visual impairment. These visual deficits are generally attributed to injuries that occur in the primary visual cortex and other visual processing systems. Recent studies suggested that neuronal damage might also occur in the retina. An important structure affecting the viability of retinal neurons is the vasculature. However, the effects of HIE on the retinal neurovasculature have not been systemically evaluated...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907818/speckle-tracking-stress-echocardiography-in-children-interobserver-and-intraobserver-reproducibility-and-the-impact-of-echocardiographic-image-quality
#10
Lucia Wilke, Francisca E Abellan Schneyder, Markus Roskopf, Andreas C Jenke, Andreas Heusch, Kai O Hensel
Speckle tracking echocardiography (STE) is increasingly used during functional assessments. However, reproducibility and dependence on echocardiographic image quality for speckle tracking stress echocardiography in pediatric patients have not been studied to date. 127 consecutive normotensive children without structural heart disease (mean age 13.4 ± 3.0 years, 50.4% female) underwent a stepwise semisupine cycle ergometric protocol. Left ventricular (LV) myocardial peak strain and strain rate were assessed at rest and during exercise...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907669/feasibility-and-reliability-of-the-spondyloarthritis-research-consortium-of-canada-sacroiliac-joint-structural-score-in-children
#11
Pamela F Weiss, Walter P Maksymowych, Robert G Lambert, Jacob L Jaremko, David M Biko, Joel Paschke, Timothy G Brandon, Rui Xiao, Nancy A Chauvin
OBJECTIVE: There is a critical need for measures to evaluate structural progression in the pediatric sacroiliac joint (SIJ). We aimed to evaluate the construct validity and reliability of the Spondyloarthritis Research Consortium of Canada SIJ Structural Score (SSS) in children with suspected or confirmed juvenile spondyloarthritis. METHODS: The SSS assesses structural lesions of the SIJ on magnetic resonance imaging (MRI) through the cartilaginous part of the joint...
June 15, 2018: Journal of Rheumatology
https://www.readbyqxmd.com/read/29907664/ventilation-inhomogeneity-in-infants-with-recurrent-wheezing
#12
Zihang Lu, Rachel E Foong, Krzysztof Kowalik, Theo J Moraes, Ayanna Boyce, Aimee Dubeau, Susan Balkovec, Per Magnus Gustafsson, Allan B Becker, Piush J Mandhane, Stuart E Turvey, Wendy Lou, Felix Ratjen, Malcolm Sears, Padmaja Subbarao
BACKGROUND: The care of infants with recurrent wheezing relies largely on clinical assessment. The lung clearance index (LCI), a measure of ventilation inhomogeneity, is a sensitive marker of early airway disease in children with cystic fibrosis, but its utility has not been explored in infants with recurrent wheezing. OBJECTIVE: To assess ventilation inhomogeneity using LCI among infants with a history of recurrent wheezing compared with healthy controls. METHODS: This is a case-control study, including 37 infants with recurrent wheezing recruited from outpatient clinics, and 113 healthy infants from a longitudinal birth cohort, the Canadian Healthy Infant Longitudinal Development study...
June 15, 2018: Thorax
https://www.readbyqxmd.com/read/29907635/increasing-rate-of-pulmonary-embolism-diagnosed-in-hospitalized-children-in-the-united-states-from-2001-to-2014
#13
Shannon L Carpenter, Troy Richardson, Matt Hall
Although rare in children, pulmonary embolism (PE) can cause significant morbidity and mortality. Overall rates of venous thromboembolism (VTE) are increasing in hospitalized children. By using the Pediatric Health Information System database, we evaluated incidence, treatment, and outcome of PE in children younger than age 18 years from 2001 to 2014. Demographic characteristics for those admitted with VTE alone and those admitted with PE were compared. Rates of PE by year were compared with the number of hospital and VTE admissions...
June 26, 2018: Blood Advances
https://www.readbyqxmd.com/read/29907630/clinical-features-of-paediatric-uveitis-at-a-tertiary-referral-centre-in-s%C3%A3-o-paulo-sp-brazil
#14
Fernanda Maria Silveira Souto, Bárbara Vilela Giampietro, Julia Thiemi Takiuti, Lucia Maria Arruda Campos, Carlos Eduardo Hirata, Joyce Hisae Yamamoto
AIMS: To analyse the clinical features, systemic associations, treatment and visual outcomes of uveitis in children from a referral centre in São Paulo, Brazil. METHODS: Clinical records of patients under 16 years old who attended the Uveitis Service, Hospital das Clinicas, Faculdadede Medicina, Universidade de São PauloFMUSP, between April and September 2017, were reviewed retrospectively. Patients with incomplete medical records, previous ocular trauma, or less than six6 months of follow-up were excluded...
June 15, 2018: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/29907485/assessment-of-vaccine-wastage-rates-missed-opportunities-and-related-knowledge-attitudes-and-practices-during-introduction-of-a-second-dose-of-measles-containing-vaccine-into-cambodia-s-national-immunization-program
#15
Aaron S Wallace, Kong Krey, John Hustedt, Eleanor Burnett, Narin Choun, Danni Daniels, Margaret L Watkins, Sann Chan Soeung, Richard Duncan
INTRODUCTION: Missed opportunities for vaccination (MOV) can result in inadequate protection against disease. Although healthcare provider reluctance to open multi-dose, lyophilized vaccine vials (particularly the measles-containing vaccine [MCV]) for every eligible child due to concerns about wasting vaccine is a known reason for MOV, little is known about providers' related attitudes and practices. METHODS: In 100 randomly selected health facilities and 24 districts of Cambodia, we surveyed healthcare providers and their district supervisors regarding routine vaccine administration and wastage knowledge and practices, and child caregivers (five per facility) regarding MOV...
June 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29907446/salvaging-the-dehisced-glans-penis
#16
C M White, M K Hanna
OBJECTIVE: The glans penis may show a deep groove (surgically favorable), or may appear flat with an absent sulcus (unfavorable). Glans dehiscence following hypospadias repair, especially after multiple surgeries, frequently results in a scarred, obliterated, or absent urethral plate. The glans penis appears to be flat and grooveless. This study reported on the outcome of a two-stage salvage repair for glans dehiscence in 49 consecutive patients. MATERIALS AND METHODS: Retrospective chart review was performed for all patients who underwent repair for glans dehiscence following hypospadias repair...
May 30, 2018: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/29907250/evaluating-risk-factors-for-differences-in-fibroid-size-and-number-using-a-large-electronic-health-record-population
#17
Michael J Bray, Eric S Torstenson, Sarah H Jones, Todd L Edwards, Digna R Velez Edwards
OBJECTIVE: To evaluate individual characteristics of women with fibroids in relation to fibroid size and number. METHODS: This cross-sectional study involved 2302 women (black and white, age range 18-87) with image- or surgery-confirmed fibroids from the Synthetic Derivative, a database of de-identified demographic and clinical information from patient electronic health records (EHRs) from the Vanderbilt University Medical Center. We performed multivariate regression analyses on the following outcomes: volume of largest fibroid, largest dimension of all fibroids, and number of fibroids (single vs multiple)...
August 2018: Maturitas
https://www.readbyqxmd.com/read/29907218/pediatric-breast-masses-an-argument-for-observation
#18
Cory M McLaughlin, Jessica Gonzalez-Hernandez, Monica Bennett, Hannah G Piper
BACKGROUND: Pediatric breast masses can be a diagnostic challenge. Nearly all are benign, but there is no consensus on which should be removed. We hypothesized that children with asymptomatic breast lesions can be safely managed nonoperatively. METHODS: We performed a single-institution retrospective review of children (≤18 y) who underwent breast mass excision from 2008 to 2016. Male patients with gynecomastia and those who had needle biopsy without formal excision were excluded...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907204/a-simulation-model-of-nail-bed-suture-and-nail-fixation-description-and-preliminary-evaluation
#19
Ida Giurin, Jean Bréaud, Virginie Rampal, Olivier Rosello, Federico Solla
BACKGROUND: Wounds of the finger nail bed represent a frequent injury, especially in children. Residents often learn nail bed repair on patients without prior training. We aimed to develop and evaluate a "low-fidelity" simulation model of nail bed repair. METHODS: The model consists of a false nail on a plastic finger and a hydrocolloid dressing, which is pasted on the nail bed site and cut horizontally. This model allows nail bed suture and nail fixation...
August 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29907090/fecal-carriage-of-multidrug-resistant-escherichia-coli-by-community-children-in-southern-taiwan
#20
I-Fei Huang, Wei-Yang Lee, Jiun-Ling Wang, Chih-Hsin Hung, Hong-Hsiang Hu, Wan-Yu Hung, Yun-Ju Hung, Wen-Chi Chen, Ying-Tso Shen, Ming-Fang Cheng
BACKGROUND: The emergence of multidrug-resistant (MDR) Escherichia coli (E. coli), particularly E. coli sequence type ST131, is becoming a global concern. Commensal bacteria, an important reservoir of antibiotic resistance genes, facilitate the spread of such genes to pathogenic bacterial strains. The objective of the study is to investigate the fecal carriage of MDR E. coli and ST131 E. coli in community children in Southern Taiwan. METHODS: In this prospective study, stool samples from children aged 0-18 years were obtained within 3 days of hospitalization from October 2013 to September 2014...
June 15, 2018: BMC Gastroenterology
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