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https://www.readbyqxmd.com/read/29045996/sicko-development-of-a-multi-disciplinary-training-concept-for-paediatric-oncology
#1
Petra Tiroke, Birte Sänger, Urs Mücke, Lea Berndt, Henrike Wittenbecher, Lorenz Grigull
Background Treating children with cancer requires multiple different skills. For the healthcare personnel (HCP) in Germany the practice of ongoing training to improve professional skills is almost non-existent. Therefore, we developed a programme called 'SICKO' to support HCPs skills and attitudes by means of a multidisciplinary workshop. Methods Following a qualitative analysis, we then designed a modular (3 day) workshop. During day one (8 h) participants learn practical skills, the fundamentals of chemotherapy, and effective communication skills...
October 18, 2017: Klinische Pädiatrie
https://www.readbyqxmd.com/read/29045978/-clinicopathologic-features-of-infant-dysembryoplastic-neuroepithelial-tumor-a-case-report-and-literature-review
#2
H Wang, J T Ye, H X Yao, D Li, Y Dong
Dysembryoplastic neuroepithelial tumor (DNT) has traditionally been viewed as rare benign tumors that present with seizure widely considered curable with surgery alone. Most DNTs occur in childhood and young adults. However, rare reported cases occur in infants. This paper reported an infant case of DNT and its diagnosis, differential diagnosis, treatment, molecular features and prognosis based on the review of current literatures. The age onset of this patient was only 11 months old. The clinical manifestations were partial seizures and the imaging data untypical; CT and MRI were all supportive of astrocytoma...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045961/-effects-of-recent-upper-respiratory-tract-infections-on-incidence-of-the-perioperative-respiratory-adverse-events-in-children-a-prospective-cohort-study
#3
C Q Li, D X Wang, T Cheng, X Y Zheng
OBJECTIVE: To investigate the effects of the recent upper respiratory tract infections (URI) on the incidence of perioperative respiratory adverse events in children scheduled to undergo general anesthesia and elective surgery. METHODS: In the study, 232 children undergoing general anesthesia with laryngeal mask airway (LMA) for elective ophthalmic surgeries at Peking University First Hospital, Beijing, China, from Nov. 1, 2015 to May 10, 2016 were enrolled. On the day of the surgery, the parents of the children were preoperatively asked to fill out a questionnaire regarding the baseline characteristics and medical history of the children, including gender, age, height, weight, history of URI within the last 2 weeks before anesthesia, history of premature, long-term passive smoking exposure, habitual sleep snoring, and history of asthma...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045952/-progress-in-diagnosis-and-management-of-syncope-in-children
#4
W R Xu, Y Liao, H F Jin, Q Y Zhang, C S Tang, J B DU
Syncope is a common emergency of children and adolescents, which has serious influence on the quality of life. Neurally-mediated syncope, including postural tachycardia syndrome, vasovagal syncope, orthostatic hypotension and orthostatic hypertension, is the main cause of syncope in children and adolescents. The main manifestations of neurally-mediated syncope are diverse, such as dizziness, headache, chest tightness, chest pain, pale complexion, fatigue, pre-syncope and syncope. Although the clinical manifestations are similar, each subtype of syncope has its hemodynamic feature and optimal treatment option...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045949/effectiveness-of-a-home-based-active-video-game-programme-in-young-cystic-fibrosis-patients
#5
Tamara Del Corral, Maria Àngels Cebrià I Iranzo, Ibai López-de-Uralde-Villanueva, Roberto Martínez-Alejos, Isabel Blanco, Jordi Vilaró
BACKGROUND: Exercise-based rehabilitation is already a part of cystic fibrosis (CF) treatment; however, patient adherence is low. OBJECTIVES: To assess the effectiveness of a home exercise programme using active video games (AVGs) as a training modality for children and adolescents with CF. METHODS: Thirty-nine children with CF were randomised to a control group (CG, n = 20, age 11 ± 6 years; FEV1 86.2 ± 20.5% of predicted) or a training group (AVGG, n = 19, age 13 ± 3 years; FEV1 82...
October 19, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/29045726/efficacy-and-safety-outcomes-in-systematic-reviews-of-interventions-for-postoperative-pain-in-children-comparison-against-the-recommended-core-outcome-set
#6
Krste Boric, Svjetlana Dosenovic, Antonia Jelicic Kadic, Matija Boric, Milka Jeric, Livia Puljak
Objective: To investigate the range of efficacy and safety outcomes used in systematic reviews (SRs) of randomized controlled trials (RCTs) of interventions for postoperative pain in children and compare them with outcome domains recommended in the Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (PedIMMPACT). Methods: Five electronic databases were searched: MEDLINE, Cochrane Database of Systematic Reviews, DARE, CINAHL, and PsycINFO...
October 16, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29045351/awareness-and-implementation-of-the-2014%C3%A2-espghan-naspghan-guideline-for-childhood-functional-constipation
#7
Ilan J N Koppen, M H Vriesman, M M Tabbers, C Di Lorenzo, M A Benninga
OBJECTIVE: To assess if physicians approach children with functional constipation according to the 2014 ESPGHAN/NASPGHAN guideline. METHODS: We invited pediatricians and pediatric gastroenterologists in the Netherlands and the U.S. to participate in this anonymous survey using a self-developed questionnaire containing 19 multiple-choice questions concerning evaluation and treatment of children with constipation. RESULTS: We included 328 physicians (67% from the U...
October 17, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29045309/cardiovascular-mortality-among-76%C3%A2-864-survivors-of-childhood-cancers-in-the-united-states-a-report-from-the-surveillance-epidemiology-and-end-results-program
#8
Saurav Uppal, Sadeer G Al-Kindi, Guilherme H Oliveira
BACKGROUND: Childhood cancer survivors have increased risk for cardiovascular disease. We sought to describe the trends of cardiovascular mortality (CVM) among survivors of childhood cancers in the United States. METHODS: We used the Surveillance, Epidemiology, and End-Results 18 database to identify all children who were diagnosed with childhood cancers between 1973 and 2013. We describe the incidence of CVM in four eras (era 1: 1973-1982, era 2: 1983-1992, era 3: 1993-2002, and era 4: 2003-2013)...
October 16, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/29045303/riluzole-serum-concentration-in-pediatric-patients-treated-for-obsessive-compulsive-disorder
#9
Paul Grant, Cristan Farmer, Jane Song, Timothy Kish, Susan Swedo
PURPOSE/BACKGROUND: The goals of this study were to determine whether pediatric serum concentration of riluzole is similar to that observed in adults and to determine whether riluzole serum concentration is associated with adverse effects or efficacy in children and adolescents with treatment-refractory obsessive-compulsive disorder. METHODS/PROCEDURES: Data were drawn from previously published studies: 1 open-label trial and 1 randomized controlled trial with an open-label extension phase...
October 17, 2017: Journal of Clinical Psychopharmacology
https://www.readbyqxmd.com/read/29045264/patterns-of-failure-in-patients-with-adult-medulloblastoma-presenting-without-extraneural-metastasis
#10
Meriem Mokhtech, Christopher G Morris, Daniel J Indelicato, Michael S Rutenberg, Robert J Amdur
OBJECTIVES: The objective of this study is to evaluate long-term outcomes, specifically patterns of tumor recurrence, in patients with adult medulloblastoma treated with radiotherapy. METHODS: We recorded outcomes of 28 (median age, 25 y) patients 18 years old or above with M0 to M3 medulloblastoma treated between 1971 and 2012. Among them, 61% had standard-risk disease. All received craniospinal irradiation with a posterior fossa boost. Median dose to the craniospinal axis was 36 Gy...
October 17, 2017: American Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29045045/mesenchymal-stromal-cell-therapy-in-bronchopulmonary-dysplasia-systematic-review-and-meta-analysis-of-preclinical-studies
#11
Sajit Augustine, Marc T Avey, Brittany Harrison, Tiffany Locke, Mona Ghannad, David Moher, Bernard Thébaud
Extreme prematurity is the leading cause of death among children under 5 years of age. Currently, there is no treatment for bronchopulmonary dysplasia (BPD), the most common complication of extreme prematurity. Experimental studies in animal models of BPD suggest that mesenchymal stromal cells (MSCs) are lung protective. To date, no systematic review and meta-analysis has evaluated the preclinical evidence of this promising therapy. Our protocol was registered with Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies prior to searching MEDLINE (1946 to June 1, 2015), Embase (1947 to 2015 Week 22), Pubmed, Web of Science, and conference proceedings (1990 to present) for controlled comparative studies of neonatal animal models that received MSCs or cell free MSC-derived conditioned media (MSC-CM)...
October 17, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29044895/surveying-all-public-drinking-water-fountains-in-a-city-outdoor-field-observations-and-google-street-view
#12
Nick Wilson, Louise Signal, George Thomson
OBJECTIVE: Drinking fountains are a public amenity that may help counter the obesogenic environment (sugary beverages) and reduce the risk of heat stroke during heat waves. As a case study, we aimed to survey all public fountains in a city: Wellington, New Zealand, and to determine the utility of Google Street View in studying drinking fountains. METHODS: Using a sample of all public drinking fountains in a City Council map, a field observer assessed their exact location and tap functionality, and photographed them...
October 18, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29044852/firework-related-injury-in-the-top-end-a-16-year-review
#13
David J Read, Richard Bradbury, Edward Yeboah
BACKGROUND: On July 1st on 'Territory Day', the public in the Northern Territory are permitted to purchase and operate consumer fireworks without a licence. Serious permanent injuries from fireworks are well described, leading to their banning in many other jurisdictions. This study describes those seriously injured by fireworks in the Top End of the Northern Territory, with the aim of identifying opportunities for prevention and harm minimization. METHODS: This is a retrospective audit of all admitted patients with an injury from fireworks at the Royal Darwin Hospital between 2000 and 2015...
October 18, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/29044790/acute-appendicitis
#14
REVIEW
Mark D Stringer
Acute appendicitis is the most common reason for abdominal surgery in children. Luminal obstruction of the appendix progresses to suppurative inflammation and perforation, which causes generalised peritonitis or an appendix mass/abscess. Classical features include periumbilical pain that migrates to the right iliac fossa, anorexia, fever, and tenderness and guarding in the right iliac fossa. Atypical presentations are particularly common in preschool children. A clinical diagnosis is possible in most cases, after a period of active observation if necessary; inflammatory markers and an ultrasound scan are useful investigations when the diagnosis is uncertain...
October 17, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29044597/short-and-long-term-complications-of-in-utero-exposure-to-lamotrigine
#15
Merav Cohen-Israel, Itai Berger, Einat Y Martonovich, Gil Klinger, Bracha Stahl, Nehama Linder
AIM: The present study evaluates the effect of antenatal lamotrigine exposure, on short and long term pediatric outcome. METHODS: The study included the children of 83 epileptic women treated with lamotrigine during pregnancy, at a tertiary medical center between 2004-2014. All newborns were monitored for vital signs, congenital malformations and Finnegan score. In addition, the parents completed a questionnaire regarding child's development and health up to the age of 12 years...
October 18, 2017: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29044519/unhealthy-dependency-in-victims-and-perpetrators-of-child-maltreatment-a-meta-analytic-review
#16
REVIEW
Fallon A Kane, Robert F Bornstein
OBJECTIVE: Theoretical conceptualizations of interpersonal dependency and dependent personality disorder suggest that (a) high levels of dependency in parents may increase risk for perpetration of child abuse and neglect and (b) children who are victimized may show elevated levels of dependency later in life. This study used meta-analytic techniques to examine these hypothesized links. METHOD: A systematic search of psychological and medical online databases revealed 14 published studies (21 effect sizes) examining the link between parental dependency and perpetration of abuse or neglect (overall N of perpetrators = 1,321), and 14 published studies (25 effect sizes) assessing dependency in victims of child abuse and neglect (overall N of victims = 38,265)...
October 17, 2017: Journal of Clinical Psychology
https://www.readbyqxmd.com/read/29044497/pediatric-headache-and-sleep-disturbance-a-comparison-of-diagnostic-groups
#17
Jonathan Rabner, Karen J Kaczynski, Laura E Simons, Alyssa LeBel
OBJECTIVE: To examine whether sleep disturbance differs by headache diagnosis in a pediatric sample, and whether this effect remains when other factors affecting sleep are included. BACKGROUND: Primary headache disorders can be severe and disabling, impacting a child's functioning and quality of life. Many children and adolescents with chronic headaches also experience sleep difficulties, and there is likely a bidirectional relationship between headaches and sleep difficulties...
October 17, 2017: Headache
https://www.readbyqxmd.com/read/29044435/impact-of-clinical-parameters-in-the-intrahost-evolution-of-hiv-1-subtype-b-in-pediatric-patients-a-machine-learning-approach
#18
Patricia Rojas Sánchez, Alberto Cobos, Marisa Navaro, José Tomas Ramos, Israel Pagán, África Holguín
Determining the factors modulating the genetic diversity of HIV-1 populations is essential to understand viral evolution. This study analyzes the relative importance of clinical factors in the intrahost HIV-1 subtype B (HIV-1B) evolution and in the fixation of drug resistance mutations (DRM) during longitudinal pediatric HIV-1 infection. We recovered 162 partial HIV-1B pol sequences (from 3 to 24 per patient) from 24 perinatally infected patients from the Madrid Cohort of HIV-1 infected children and adolescents in a time interval ranging from 2...
October 1, 2017: Genome Biology and Evolution
https://www.readbyqxmd.com/read/29044069/primary-nonendoscopic-endonasal-versus-external-dacryocystorhinostomy-in-nasolacrimal-duct-obstruction-in-children
#19
Nandini Bothra, Raashid M Wani, Anasua Ganguly, Devjyoti Tripathy, Suryasnata Rath
PURPOSE: The aim is to compare the outcome of nonendoscopic endonasal dacryocystorhinostomy (NEN DCR) with external DCR (EXT-DCR) in the treatment of nasolacrimal duct obstruction (NLDO) in children. METHODS: A retrospective, comparative chart analysis of all consecutive children <16 years after EXT-DCR or NEN-DCR between June 2012 and February 2016. RESULTS: Seventy-one children (79 eyes) underwent DCR in the study, of which 37 children (40 eyes) underwent EXT-DCR and 34 (39 eyes) NEN-DCR...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29044060/interocular-symmetry-of-retinal-nerve-fiber-layer-and-optic-nerve-head-parameters-measured-by-cirrus-high-definition-optical-coherence-tomography-in-a-normal-pediatric-population
#20
Neelam Pawar, Devendra Maheshwari, Meenakshi Ravindran, Renagappa Ramakrishnan
PURPOSE: To determine interocular differences in the retinal nerve fiber layer (RNFL) and optic nerve head (ONH) parameters in a pediatric population using Cirrus high-definition optical coherence tomography (HD-OCT). METHODS: Seventy normal Indian children aged 5-17 years presenting to the Pediatric Clinic were included in this observational cross-sectional study. All subjects underwent a comprehensive ophthalmologic examination and an evaluation of the RNFL and ONH by Cirrus HD-OCT...
October 2017: Indian Journal of Ophthalmology
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