Junli Shao, Chengze Lai, Qiuyi Zheng, Yu Luo, Chengji Li, Bin Zhang, Yanqin Sun, Shizhen Liu, Yingying Shi, Jinglin Li, Zuguo Zhao, Lianxian Guo
Arsenic, a ubiquitous environmental toxicant with various forms and complex food matrix interactions, can reportedly exert differential effects on the liver compared to drinking water exposure. To examine its specific liver-related harms, we targeted the liver in C57BL/6 J mice (n=48, 8-week-old) fed with arsenic-contaminated food (30 mg/kg) for 60 days, mimicking the rice arsenic composition observed in real-world scenarios (iAsV : 7.3%, iAsIII : 72.7%, MMA: 1.0%, DMA: 19.0%). We then comprehensively evaluated liver histopathology, metabolic changes, and the potential role of the gut-liver axis using human hepatocellular carcinoma cells (HepG2) and microbiota/metabolite analyses...
March 8, 2024: Ecotoxicology and Environmental Safety