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Interventional spinal Injections

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https://www.readbyqxmd.com/read/29920172/the-protection-of-acute-spinal-cord-injury-by-subarachnoid-space-injection-of-danshen-in-animal-models
#1
Yong-Gui Yu, Jian Yang, Xin-Hua Cheng, Wei Shang, Bing-Hao Zhao, Fei Zhao, Zhi-Guo Chen, Zhen-Hua Huang
Context/Objective Following acute spinal cord injury (ASCI) in rabbits, subarachnoid space injection of Danshen was performed to protect the neurological damage. In this study, we established rabbit models of spinal cord injury using a modified Allen's method. Design After the operation introducing the injuries, the rabbits were randomized into two different groups, control group (normal saline, NS) and Danshen, a component extracted from Chinese herb, treatment group. Each rabbit was supplied with either the drug or placebo at 0...
June 19, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29883820/extensive-spinal-adhesive-arachnoiditis-after-extradural-spinal-infection-spinal-dura-mater-is-no-barrier-to-inflammation
#2
Theresa Krätzig, Marc Dreimann, Klaus Christian Mende, Ingo Königs, Manfred Westphal, Sven Oliver Eicker
BACKGROUND: Spinal adhesive arachnoiditis (SAA) is an inflammatory process of the meninges. Cystic changes and cicatrisation may lead to neurological deficits and immobilization. Therapy is difficult and often unsatisfactory. We describe eight cases of extensive SAA following extradural spinal infection. METHODS: 238 patients with epidural abscess or osteomyelitis were treated at our institution between 2011 and 2018. We identified eight patients who developed extensive SAA on follow-up...
June 5, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29880162/comparison-of-local-and-intra-venous-dexamethasone-on-post-operative-pain-and-recovery-after-caeseream-section-a-randomized-controlled-trial
#3
Ahmed M Maged, Wesam Sayed Deeb, Sahar Elbaradie, Ahmed R Elzayat, Ahmed A Metwally, Mohamed Hamed, Ahmed Shaker
OBJECTIVE: To compare the effect of local infiltration and intravenous dexamethasone on postoperative pain and recovery after Cesarean Section (CS). MATERIAL AND METHODS: A Prospective, randomized study conducted on 120 pregnant women attending the labor wards. All participants were scheduled for elective CS under spinal anaesthesia and were randomly divided into 3 equal groups. Group 1 received 16 mg Dexamethasone IV drip. Group II received 16 mg Dexamethasone subcutaneous injection around the caesarean section scar after skin closure and Group III received Placebo (500 cc saline infusion)...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29871373/response-to-cervical-medial-branch-blocks-in-patients-with-cervicogenic-vertigo
#4
Tim Hahn, Marc-Eric Halatsch, Christian Wirtz, Stephan Klessinger
BACKGROUND: Among the various causes of vertigo, the so-called cervicogenic vertigo (CV) has been the most controversial. However, perturbations of proprioceptive signals and abnormal activity of the cervical afferents can induce vertigo. Medial branch blocks (MBBs) are a diagnostic tool designed to test whether a patient's neck pain is mediated by one or more of the medial branches of the dorsal rami of the spinal nerve. It is unknown whether MBBs are also suitable for testing symptoms other than pain...
May 2018: Pain Physician
https://www.readbyqxmd.com/read/29860396/eliciting-inflammation-enables-successful-rehabilitative-training-in-chronic-spinal-cord-injury
#5
Abel Torres-Espín, Juan Forero, Keith K Fenrich, Ana M Lucas-Osma, Aleksandra Krajacic, Emma Schmidt, Romana Vavrek, Pamela Raposo, David J Bennett, Phillip G Popovich, Karim Fouad
Rehabilitative training is one of the most successful therapies to promote motor recovery after spinal cord injury, especially when applied early after injury. Polytrauma and management of other medical complications in the acute post-injury setting often preclude or complicate early rehabilitation. Therefore, interventions that reopen a window of opportunity for effective motor training after chronic injury would have significant therapeutic value. Here, we tested whether this could be achieved in rats with chronic (8 weeks) dorsolateral quadrant sections of the cervical spinal cord (C4) by inducing mild neuroinflammation...
May 30, 2018: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29858776/pain-inhibits-pain-an-ascending-descending-pain-modulation-pathway-linking-mesolimbic-and-classical-descending-mechanisms
#6
Glaucia Tobaldini, Natalia F Sardi, Vinicius A Guilhen, Luana Fischer
The ability to modulate pain perception is as critical to survival as pain itself. The most known pain modulation pathway is the PAG-RVM (periaqueductal gray-rostral ventromedial medulla) descending system. In this study, we hypothesized that it is functionally linked to the ascending nociceptive control, which is a form of pain-induced analgesia dependent on mesolimbic mechanisms. To test this hypothesis, we used a pharmacological approach, in which the antinociception induced by noxious stimulation (forepaw injection of capsaicin) was detected in a standard rat model of inflammatory pain (hindpaw injection of carrageenan)...
June 1, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29847797/inhibition-of-neuroinflammation-by-aibp-spinal-effects-upon-facilitated-pain-states
#7
Sarah A Woller, Soo-Ho Choi, Eun Jung An, Hann Low, Dina A Schneider, Roshni Ramachandran, Jungsu Kim, Yun Soo Bae, Dmitri Sviridov, Maripat Corr, Tony L Yaksh, Yury I Miller
Apolipoprotein A-I binding protein (AIBP) reduces lipid raft abundance by augmenting the removal of excess cholesterol from the plasma membrane. Here, we report that AIBP prevents and reverses processes associated with neuroinflammatory-mediated spinal nociceptive processing. The mechanism involves AIBP binding to Toll-like receptor-4 (TLR4) and increased binding of AIBP to activated microglia, which mediates selective regulation of lipid rafts in inflammatory cells. AIBP-mediated lipid raft reductions downregulate LPS-induced TLR4 dimerization, inflammatory signaling, and expression of cytokines in microglia...
May 29, 2018: Cell Reports
https://www.readbyqxmd.com/read/29777277/impact-of-muscle-atrophy-on-bone-metabolism-and-bone-strength-implications-for-muscle-bone-crosstalk-with-aging-and-disuse
#8
REVIEW
T Bettis, B-J Kim, M W Hamrick
Bone fractures in older adults are often preceded by a loss of muscle mass and strength. Likewise, bone loss with prolonged bed rest, spinal cord injury, or with exposure to microgravity is also preceded by a rapid loss of muscle mass. Recent studies using animal models in the setting of hindlimb unloading or botulinum toxin (Botox) injection also reveal that muscle loss can induce bone loss. Moreover, muscle-derived factors such as irisin and leptin can inhibit bone loss with unloading, and knockout of catabolic factors in muscle such as the ubiquitin ligase Murf1 or the myokine myostatin can reduce osteoclastogenesis...
May 18, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29770432/automated-mandatory-bolus-versus-basal-infusion-for-maintenance-of-epidural-analgesia-in-labour
#9
REVIEW
Ban Leong Sng, Yanzhi Zeng, Nurun Nisa A de Souza, Wan Ling Leong, Ting Ting Oh, Fahad Javaid Siddiqui, Pryseley N Assam, Nian-Lin R Han, Edwin Sy Chan, Alex T Sia
BACKGROUND: Childbirth may cause the most severe pain some women experience in their lifetime. Epidural analgesia is an effective form of pain relief during labour and is considered to be the reference standard. Traditionally epidural analgesia has been delivered as a continuous infusion via a catheter in the epidural space, with or without the ability for the patient to supplement the analgesia received by activating a programmable pump to deliver additional top-up doses, known as patient-controlled epidural analgesia (PCEA)...
May 17, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29767782/factfinders-for-patient-safety-are-gadolinium-based-contrast-media-safe-alternatives-to-iodinated-contrast-agents-for-the-safe-performance-of-spinal-injection-procedures
#10
Adrian Popescu, Jaymin Patel, Zachary L McCormick, Timothy P Maus, Meghan Rodes, David R Walega, Clark C Smith
No abstract text is available yet for this article.
May 14, 2018: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29742720/sacral-epiduroscopic-laser-decompression-for-complex-regional-pain-syndrome-after-lumbar-spinal-surgery-a-case-report
#11
Jae-Wook Jung, Yong Han Kim, Hyojoong Kim, Eunsu Kang, Hyunji Jo, Myoung Jin Ko
RATIONALE: CRPS after a lumbar surgery has symptoms that are similar to PSSS. However, standard criteria for distinguishing CRPS from PSSS do not exist. We present a case report of a 31-year-old female with CRPS symptoms after lumbar spinal surgery treated by performing SELD. PATIENT CONCERNS: This patient was referred to our pain clinic for left ankle pain. She received a lumbar discectomy for a herniated lumbar disc (L5/S1) but the pain was aggravated after surgery...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29742708/the-effectiveness-and-safety-of-nonsurgical-integrative-interventions-for-symptomatic-lumbar-spinal-spondylolisthesis-a-randomized-controlled-multinational-multicenter-trial-protocol
#12
RANDOMIZED CONTROLLED TRIAL
Kiok Kim, Yousuk Youn, Sang Ho Lee, Jung Chul Choi, Jae Eun Jung, Jaehong Kim, Wenchun Qu, Jason Eldrige, Tae-Hun Kim
BACKGROUND: Surgery is generally accepted as the main therapeutic option for symptomatic lumbar spondylolisthesis. However, new nonsurgical therapeutic options need to be explored for this population. OBJECTIVES: The objective of this study is to assess the effectiveness and safety of a 5-week Mokhuri treatment program compared with conventional nonsurgical treatments for symptomatic lumbar spondylolisthesis. METHODS: This is a study protocol for a multinational, multicenter clinical randomized controlled trial comparing the effectiveness and safety of 5 weeks of nonsurgical integrative treatments (a Mokhuri treatment program consisting of Chuna, acupuncture, and patient education) with nonsurgical conventional treatments (drugs for pain relief, epidural steroid injections, and physical therapy)...
May 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29705337/cost-effectiveness-of-circumferential-fusion-for-lumbar-spondylolisthesis-propensity-matched-comparison-of-transforaminal-lumbar-interbody-fusion-versus-anterior-posterior-fusion
#13
Ehsan Jazini, Jeffrey L Gum, Steven D Glassman, Charles H Crawford, Mladen Djurasovic, R Kirk Owens, John R Dimar, Katlyn E McGraw, Leah Y Carreon
BACKGROUND CONTEXT: Transforaminal Lumbar Interbody Fusion (TLIF) and dual approach antero-posterior (AP) are common techniques to achieve circumferential fusion for lumbar spondylolisthesis. It is unclear which approach is more cost-effective. PURPOSE: Our goal is to determine the incremental cost-effectiveness ratio (ICER) by calculating the cost per quality-adjusted life year (QALY) for each approach. STUDY DESIGN/SETTING: Propensity matched cost-effectiveness comparison...
April 26, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29685405/high-prevalence-of-greater-trochanteric-pain-syndrome-among-patients-presenting-to-spine-clinic-for-evaluation-of-degenerative-lumbar-pathologies
#14
Lee A Tan, Barlas Benkli, Alexander Tuchman, Xudong J Li, Natasha N Desai, Thomas S Bottiglieri, Jeffrey Pavel, Lawrence G Lenke, Ronald A Lehman
BACKGROUND: Greater trochanteric pain syndrome (GTPS) is a relatively common diagnosis among the general population. OBJECTIVE: We aim to determine the prevalence of GTPS among patients who presented to the spine clinic. METHODS: Medical records of patients who were evaluated in the spine clinic were reviewed over a 12-month period (4/1/2016 to 3/31/2017). Patient demographics, presenting symptomatology, physical examination findings, presence or absence of GTPS, medical imaging findings, and interventions were recorded analyzed...
July 2018: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29618074/letter-epidural-steroid-injection-induced-menorrhagia-an-under-recognized-complication-associated-with-a-common-spinal-intervention
#15
Ketan Yerneni, John F Burke, Lee A Tan
No abstract text is available yet for this article.
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29573872/prevention-and-treatment-of-low-back-pain-evidence-challenges-and-promising-directions
#16
REVIEW
Nadine E Foster, Johannes R Anema, Dan Cherkin, Roger Chou, Steven P Cohen, Douglas P Gross, Paulo H Ferreira, Julie M Fritz, Bart W Koes, Wilco Peul, Judith A Turner, Chris G Maher
Many clinical practice guidelines recommend similar approaches for the assessment and management of low back pain. Recommendations include use of a biopsychosocial framework to guide management with initial non-pharmacological treatment, including education that supports self-management and resumption of normal activities and exercise, and psychological programmes for those with persistent symptoms. Guidelines recommend prudent use of medication, imaging, and surgery. The recommendations are based on trials almost exclusively from high-income countries, focused mainly on treatments rather than on prevention, with limited data for cost-effectiveness...
March 20, 2018: Lancet
https://www.readbyqxmd.com/read/29565952/the-effect-of-bipolar-pulsed-radiofrequency-treatment-on-chronic-lumbosacral-radicular-pain-refractory-to-monopolar-pulsed-radiofrequency-treatment
#17
Dong Gyu Lee, Yun Woo Cho, Sang Ho Ahn, Min Cheol Chang
BACKGROUND: Patients with lumbosacral radicular pain may complain of persisting pain after monopolar pulsed radiofrequency (PRF) treatment. OBJECTIVE: We evaluated the effect of bipolar PRF stimulation of the dorsal root ganglion (DRG) in patients with chronic lumbosacral radicular pain who were unresponsive to both monopolar PRF stimulation of the DRG and transforaminal epidural steroid injection (TFESI). STUDY DESIGN: This is a prospective observational study...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29565946/anatomy-pathophysiology-and-interventional-therapies-for-chronic-pelvic-pain-a-review
#18
Corey W Hunter, Brad Stovall, Grant Chen, Jonathan Carlson, Robert Levy
BACKGROUND: Chronic pelvic pain (CPP) represents a group of poorly understood disorders that are often refractory to conventional treatment. Referral to pain management typically occurs later in the continuum of care; as such, many of the injections and nerve blocks commonly prescribed for such patients are potentially limited in efficacy. While neuromodulation is conventionally considered the next algorithmic step in the treatment of chronic pain after injections fail, there is a common perception that neuromodulation is largely ineffective for CPP conditions...
March 2018: Pain Physician
https://www.readbyqxmd.com/read/29550454/microrna-146a-5p-attenuates-visceral-hypersensitivity-through-targeting-chemokine-ccl8-in-the-spinal-cord-in-a-mouse-model-of-colitis
#19
Ying Lu, De-Li Cao, Lin-Xia Zhao, Yu Han, You-Li Zhang
Visceral pain, observed in inflammatory bowel disease (IBD) patients, is a challenging medical problem and remains poorly understood because the mechanisms underlying it are unclear. Emerging evidence indicates that microRNAs (miRNAs) play a crucial role in the pathogenesis of acute and chronic pain. In this study, we aimed to explore the potential role of miR-146a-5p (the mature form of miR-146a) in a mouse model of colitis induced by intracolonic injection of trinitrobenzene sulfonic acid (TNBS). We found that induction of colitis resulted in visceral hyperalgesia manifested by a decreased pain threshold to colorectal distension and upregulation of miR-146a-5p expression in the lumbosacral spinal cord...
May 2018: Brain Research Bulletin
https://www.readbyqxmd.com/read/29533040/-effects-of-decompression-combined-with-electro-acupuncture-on-rat-with-acute-severe-upper-cervical-spinal-cord-compression-injury
#20
Ming-Sheng Tan, Yan-Lei Wang, Ying-Na Qi, Chun-Ke Dong, Wei Wang, Ping Yi, Feng Yang, Xiang-Sheng Tang, Qing-Ying Hao
OBJECTIVE: To explore the effect and underlying mechanism of decompression(DE)combined with Governor Vessel(GV)electro-acupuncture(EA) on rats with acute severe upper cervical spinal cord compression injury. METHODS: Thirty SPF rats were randomly divided into 5 groups(control group A, B and experiment group C, D, E), 6 rats in each group. The model of acute severe upper cervical spinal cord compression injury were made by forcing a balloon catheter put in atlas pillow clearance...
January 25, 2018: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
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