keyword
MENU ▼
Read by QxMD icon Read
search

Statistical genetics

keyword
https://www.readbyqxmd.com/read/29049220/the-association-between-ccnd1-g870a-polymorphism-and-colorectal-cancer-risk-a-meta-analysis
#1
Mei Xie, Fen Zhao, Xiaoling Zou, Shuai Jin, Shaoquan Xiong
BACKGROUND: CyclinD1 (CCND1) is a key cell cycle regulatory protein. A large number of epidemiological studies have assessed the potential correlation between the CCND1 G870A polymorphism and the risk of colorectal cancer (CRC), but their findings have been inconsistent. To obtain a more precise understanding of the association between the G870A polymorphism in the CCND1 gene and the CRC risk, we conducted a more comprehensive meta-analysis. METHODOLOGY: We searched PubMed, Ovid, Springer, Weipu, China National Knowledge Infrastructure (CNKI), and Wanfang databases, covering all publications (the last search was updated on January 10, 2017)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049185/relationship-between-add1-gly460trp-gene-polymorphism-and-essential-hypertension-in-madeira-island
#2
Ana Célia Sousa, Roberto Palma Dos Reis, Andreia Pereira, Sofia Borges, Ana Isabel Freitas, Graça Guerra, Teresa Góis, Mariana Rodrigues, Eva Henriques, Sónia Freitas, Ilídio Ornelas, Décio Pereira, António Brehm, Maria Isabel Mendonça
Essential hypertension (EH) is a complex disease in which physiological, environmental, and genetic factors are involved in its genesis. The genetic variant of the alpha-adducin gene (ADD1) has been described as a risk factor for EH, but with controversial results.The objective of this study was to evaluate the association of ADD1 (Gly460Trp) gene polymorphism with the EH risk in a population from Madeira Island.A case-control study with 1614 individuals of Caucasian origin was performed, including 817 individuals with EH and 797 controls...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049177/association-of-bmp-14-rs143383-ploymorphism-with-its-susceptibility-to-osteoarthritis-a-meta-analysis-and-systematic-review-according-to-prisma-guideline
#3
Yi Yin, Yan Wang
BACKGROUND: Osteoarthritis (OA) is a complex disease which can be caused by both environmental and genetic factors. A functional locus rs143383 of bone morphogenetic protein-14 (BMP-14) has been pointed out to be associated with OA etiology, but conflicting conclusions have been reached. To provide a more comprehensive conclusion about this issue, we performed this meta-analysis. METHODS: Relevant studies were searched from electronic databases including PubMed, Chinese National Knowledge Infrastructure, Embase, and Wanfang...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29049139/the-role-of-the-cys23ser-rs6318-polymorphism-of-the-htr2c-gene-in-suicidal-behavior-systematic-review-and-meta-analysis
#4
Thelma B González-Castro, Yazmín Hernandez-Diaz, Isela E Juárez-Rojop, Lilia López-Narváez, Carlos A Tovilla-Zárate, José M Rodriguez-Perez, Juan P Sánchez-de la Cruz
OBJECTIVE: The polymorphisms of the serotonin receptor 2C (HTR2C) gene have been proposed to influence suicidal behavior. The aim of our study was to explore the role of the HTR2C gene variant Cys23Ser (rs6318) in the pathogenesis of suicidal behavior through a systematic review and meta-analysis. METHODS: The search was performed using EBSCO and PubMed databases. To be included in the analysis, the studies had to evaluate suicidal behavior (attempted, ideation, or completed suicide)...
October 18, 2017: Psychiatric Genetics
https://www.readbyqxmd.com/read/29048744/comorbidity-of-alcohol-use-disorder-and-chronic-pain-genetic-influences-on-brain-reward-and-stress-systems
#5
REVIEW
Ellen W Yeung, Jason G Craggs, Ian R Gizer
Alcohol use disorder (AUD) is highly comorbid with chronic pain (CP). Evidence has suggested that neuroadaptive processes characterized by reward deficit and stress surfeit are involved in the development of AUD and pain chronification. Neurological data suggest that shared genetic architecture associated with the reward and stress systems may contribute to the comorbidity of AUD and CP. This monograph first delineates the prevailing theories of the development of AUD and pain chronification focusing on the reward and stress systems...
October 19, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/29048524/krait-an-ultrafast-tool-for-genome-wide-survey-of-microsatellites-and-primer-design
#6
Lianming Du, Chi Zhang, Qin Liu, Xiuyue Zhang, Bisong Yue
Summary: Microsatellites are found to be related with various diseases and widely used in population genetics as genetic markers. However, it remains a challenge to identify microsatellite from large genome and screen microsatellites for primer design from a huge result dataset. Here, we present Krait, a robust and flexible tool for fast investigation of microsatellites in DNA sequences. Krait is designed to identify all types of perfect or imperfect microsatellites on a whole genomic sequence, and is also applicable to identification of compound microsatellites...
October 18, 2017: Bioinformatics
https://www.readbyqxmd.com/read/29048420/characterization-of-pulmonary-arteriovenous-malformations-in-acvrl1-versus-eng-mutation-carriers-in-hereditary-hemorrhagic-telangiectasia
#7
Weiyi Mu, Zachary A Cordner, Kevin Yuqi Wang, Kate Reed, Gina Robinson, Sally Mitchell, Doris Lin
PurposePulmonary arteriovenous malformations (pAVMs) are major contributors to morbidity and mortality in hereditary hemorrhagic telangiectasia (HHT). Mutations in ENG and ACVRL1 underlie the vast majority of clinically diagnosed cases. The aims of this study were to characterize and compare the clinical and morphologic features of pAVMs between these two genotype groups.MethodsSixty-six patients with HHT and affected family members were included. Genotype, phenotypic data, and imaging were obtained from medical records...
October 19, 2017: Genetics in Medicine: Official Journal of the American College of Medical Genetics
https://www.readbyqxmd.com/read/29047346/mapping-eqtl-by-leveraging-multiple-tissues-and-dna-methylation
#8
Chaitanya R Acharya, Kouros Owzar, Andrew S Allen
BACKGROUND: DNA methylation is an important tissue-specific epigenetic event that influences transcriptional regulation of gene expression. Differentially methylated CpG sites may act as mediators between genetic variation and gene expression, and this relationship can be exploited while mapping multi-tissue expression quantitative trait loci (eQTL). Current multi-tissue eQTL mapping techniques are limited to only exploiting gene expression patterns across multiple tissues either in a joint tissue or tissue-by-tissue frameworks...
October 18, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29046403/distinguishing-among-modes-of-convergent-adaptation-using-population-genomic-data
#9
Kristin M Lee, Graham Coop
Geographically separated populations can convergently adapt to the same selection pressure. Convergent evolution at the level of a gene may arise via three distinct modes. The selected alleles can (1) have multiple independent mutational origins, (2) be shared due to shared ancestral standing variation, or (3) spread throughout subpopulations via gene ow. We present a model-based, statistical approach that utilizes genomic data to detect cases of convergent adaptation at the genetic level, identify the loci involved and distinguish among these modes...
October 18, 2017: Genetics
https://www.readbyqxmd.com/read/29045954/-pulmonary-arterial-hypertension-as-leading-manifestation-of-methylmalonic-aciduria-clinical-characteristics-and-gene-testing-in-15-cases
#10
X Q Liu, H Yan, J X Qiu, C Y Zhang, J G Qi, X Zhang, H J Xiao, Y L Yang, Y H Chen, J B DU
OBJECTIVE: To deepen our understanding of Methylmalonic aciduria (MMA) associated pulmonary hypertension (PH) by analyzing the characteristics of clinical presentation, pulmonary high resolusion CT(HRCT), treatment response and gene mutation. METHODS: This study includes 15 cases of pediatric patients with MMA associated PH diagnosed and treated in Peking University First Hospital pediatric department between May 2012 and May 2016 with symptoms of PH as their leading presentation...
October 18, 2017: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29045754/genomic-studies-of-local-adaptation-in-natural-plant-populations
#11
Victoria L Sork
Local adaptation arises as a result of selection by the local environment favoring phenotypes that enhance fitness. Geographic patterns of phenotypic variation are in part due to this selective process. Classically, the genetic basis of those phenotypes has been studied in plant populations using a quantitative genetic approach in which plants from different source populations are grown in common environments, in reciprocal transplant experiments, or in studies across a wide geographic and environmentally heterogeneous area...
October 14, 2017: Journal of Heredity
https://www.readbyqxmd.com/read/29044475/the-site-of-care-matters-an-examination-of-the-relationship-between-high-medicaid-burden-hospitals-and-the-use-cost-and-complications-of-immediate-breast-reconstruction-after-mastectomy
#12
Anaeze C Offodile, L Daniel Muldoon, Faiz Gani, Joseph K Canner, Lisa K Jacobs
BACKGROUND: Diminished use and worse outcomes after immediate breast reconstruction (IBR) have been documented for Medicaid beneficiaries. However, to the authors' knowledge, the contribution of patient clustering at hospitals with a high percentage of Medicaid patients to these inequalities in IBR delivery is unknown. METHODS: A cross-sectional analysis of patients undergoing IBR after mastectomy using the 2007 to 2011 Nationwide Inpatient Sample database was performed...
October 17, 2017: Cancer
https://www.readbyqxmd.com/read/29044472/population-stratification-in-genetic-association-studies
#13
Jacklyn N Hellwege, Jacob M Keaton, Ayush Giri, Xiaoyi Gao, Digna R Velez Edwards, Todd L Edwards
Population stratification (PS) is a primary consideration in studies of genetic determinants of human traits. Failure to control for PS may lead to confounding, causing a study to fail for lack of significant results, or resources to be wasted following false-positive signals. Here, historical and current approaches for addressing PS when performing genetic association studies in human populations are reviewed. Methods for detecting the presence of PS, including global and local ancestry methods, are described...
October 18, 2017: Current Protocols in Human Genetics
https://www.readbyqxmd.com/read/29044470/analysis-of-gene-gene-interactions
#14
Brian S Cole, Molly A Hall, Ryan J Urbanowicz, Diane Gilbert-Diamond, Jason H Moore
The goal of this unit is to introduce epistasis, or gene-gene interactions, as a significant contributor to the genetic architecture of complex traits, including disease susceptibility. This unit begins with an historical overview of the concept of epistasis and the challenges inherent in the identification of potential gene-gene interactions. Then, it reviews statistical and machine learning methods for discovering epistasis in the context of genetic studies of quantitative and categorical traits. This unit concludes with a discussion of meta-analysis, replication, and other topics of active research...
October 18, 2017: Current Protocols in Human Genetics
https://www.readbyqxmd.com/read/29044056/association-of-polymorphisms-in-the-intron-of-tcf4-gene-to-late-onset-fuchs-endothelial-corneal-dystrophy-an-indian-cohort-study
#15
Bhavna S Rao, Arokiasamy Tharigopala, Sudhir R Rachapalli, Rama Rajagopal, Nagasamy Soumittra
PURPOSE: Fuchs endothelial corneal dystrophy (FECD) is a progressive degenerative disease of the corneal endothelium. It is genetically heterogeneous and follows either an autosomal dominant or sporadic pattern of inheritance. Here, we have explored the association of four previously reported intronic single nucleotide polymorphisms and intronic CTG repeat expansions in TCF4 gene to FECD in an Indian cohort. METHODS: The cohort consisting of 52 sporadic late-onset cases, 5 early-onset cases, and 148 controls was taken for the study...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29044055/assessment-of-bicc-family-rna-binding-protein-1-and-ras-protein-specific-guanine-nucleotide-releasing-factor-1-as-candidate-genes-for-high-myopia-a-case-control-study
#16
Li Hepei, Xie Mingkun, Wang Li, Wu Jin
PURPOSE: The aim is to evaluate the association between high myopia and genetic variant in the BicC family RNA binding protein 1 (BICC1) as well as its association with Ras protein specific guanine nucleotide releasing factor 1 (RASGRF1) genes in a Chinese Han population with a case-control study. METHODS: Five TagSNPs in BICC1 and RASGRF1 genes were selected and genotyped in 821 unrelated subjects, which composed of 419 controls (spherical equivalent within ±1...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29043699/multiplex-polymerase-chain-reaction-for-detecting-microdeletions-in-the-azoospermia-factor-region-of-y-chromosome-in-iranian-couples-with-non-obstructive-infertility-and-recurrent-pregnancy-loss
#17
Afsaneh Mojtabanezhad Shariatpanahi, Hassan Ahmadnia, Adam Torkamanzehi, Mahnaz Mansouri Torshizi, Mohammad Amin Kerachian
Background: Approximately 15% of couples are infertile with the male factor explaining approximately 50% of the cases. One of the main genetic factors playing a role in male infertility is Y chromosomal microdeletions within the proximal long arm of the Y chromosome (Yq11), named the azoospermia factor (AZF) region. Recent studies have shown there is a potential connection between deletions of the AZF region and recurrent pregnancy loss (RPL). The aim of this study is to examine this association by characterizing AZF microdeletions in two infertile groups: in men with non-obstructive infertility and in men with wives displaying RPL...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29043515/the-2018-international-workshop-on-statistical-genetic-methods-for-human-complex-traits-formerly-the-methodology-of-twin-and-family-studies-introductory-workshop-march-5th-march-9th-2018
#18
https://www.readbyqxmd.com/read/29043102/the-distribution-of-calbindin-d28k-parvalbumin-and-calretinin-immunoreactivity-in-the-inferior-colliculus-of-circling-mouse
#19
Jin-Koo Lee, Myeung Ju Kim
The circling mice with tmie gene mutation are known as an animal deafness model, which showed hyperactive circling movement. Recently, the reinvestigation of circling mouse was performed to check the inner ear pathology as a main lesion of early hearing loss. In this trial, the inner ear organs were not so damaged to cause the hearing deficit of circling (cir/cir) mouse at 18 postnatal day (P18) though auditory brainstem response data indicated hearing loss of cir/cir mice at P18. Thus, another mechanism may be correlated with the early hearing loss of cir/cir mice at P18...
September 2017: Anatomy & Cell Biology
https://www.readbyqxmd.com/read/29042150/paul-joyce-and-the-infinite-alleles-model
#20
Stephen M Krone
Paul Joyce's work touched on a variety of topics in population genetics-from mathematical models of idealized systems to working closely with biologists on experimental evolution and landscape genetics. I will focus on his earlier mathematical/statistical work that centered on the infinite alleles model.
October 14, 2017: Theoretical Population Biology
keyword
keyword
80094
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"