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https://www.readbyqxmd.com/read/29160060/phase-transition-nanoparticles-as-multimodality-contrast-agents-for-the-detection-of-thrombi-and-targeting-thrombolysis-in-vitro-and-in-vivo-experiments
#1
Jie Xu, Jun Zhou, Yixin Zhong, Yu Zhang, Jia Liu, Yuli Chen, Liming Deng, Danli Sheng, Zhigang Wang, Haitao Ran, Dajing Guo
Thrombotic disease is extremely harmful to human health, and early detection and treatment can improve the prognosis and reduce mortality. Multimodal molecular imaging can provide abundant information about thrombi, but to date, few studies have used multimodal and multifunctional nanoparticles (NPs) for thrombus detection and targeting thrombolysis. In this study, phase transition multimodal and multifunctional NPs (EWVDV-Fe-Ink-PFH NPs) were constructed for the first time using a three-step emulsification and carbodiimide method, and the physical and chemical properties of the NPs were investigated...
November 21, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29158937/connatal-urinary-ascites-in-a-female-preterm
#2
Barbara Brunner, Elisabeth Ralser, Elisabeth D'Costa, Kathrin Maurer, Ursula Kiechl-Kohlendorfer, Elke Griesmaier
Background: Connatal urinary ascites is rare in females without associated malformations and occurs following bladder rupture. Case Presentation: A female very preterm was delivered by caesarean section because of abnormal Doppler findings. The mother suffered from viral pneumonia requiring intensive care in the third trimester of pregnancy. Serial fetal ultrasound examinations showed a megacystis and ascites. Postnatally, pronounced isolated ascites was drained and its urinary nature was confirmed...
2017: Case Reports in Pediatrics
https://www.readbyqxmd.com/read/29158836/a-laser-activated-biocompatible-theranostic-nanoagent-for-targeted-multimodal-imaging-and-photothermal-therapy
#3
Liming Deng, Xiaojun Cai, Danli Sheng, Yang Yang, Eric M Strohm, Zhigang Wang, Haitao Ran, Dong Wang, Yuanyi Zheng, Pan Li, Tingting Shang, Yi Ling, Fengjuan Wang, Yang Sun
Multifunctional nanoparticles have been reported for cancer detection and treatment currently. However, the accurate diagnosis and efficient treatment for tumors are still not satisfied. Here we report on the development of targeted phase change multimodal polymeric nanoparticles for the imaging and treatment of HER2-positive breast cancer. METHODS: We evaluated the multimodal imaging capabilities of the prepared nanoparticles in vitro using agar-based phantoms. The targeting performance and cytotoxicity of the nanoparticles were examined in cell culture using SKBR3 (over-expressing HER2) and MDA-MB-231 (HER2 negative) cells...
2017: Theranostics
https://www.readbyqxmd.com/read/29157478/treatment-of-low-flow-vascular-malformations-of-the-extremities-using-mr-guided-high-intensity-focused-ultrasound-preliminary-experience
#4
Pejman Ghanouni, Sirish Kishore, Matthew P Lungren, Rachelle Bitton, Lauren Chan, Raffi Avedian, Alberto Bazzocchi, Kim Butts Pauly, Alessandro Napoli, David M Hovsepian
Five patients with painful vascular malformations of the extremities that were refractory to standard treatment and were confirmed as low-flow malformations on dynamic contrast-enhanced magnetic resonance (MR) imaging were treated with MR imaging-guided high intensity focused ultrasound. Daily maximum numeric rating scale scores for pain improved from 8.4 ± 1.5 to 1.6 ± 2.2 (P = .004) at a median follow-up of 9 months (range, 4-36 mo). The size of the vascular malformations decreased on follow-up MR imaging (median enhancing volume, 8...
December 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/29157067/role-of-endoscopic-ultrasound-in-the-management-of-tubercular-uveitis
#5
Deepa Sharma, Manisha Agarwal, Vikas Singla, Vivek Jha, Ankita Shrivastav
PURPOSE: To evaluate the role and safety of endoscopic ultrasound-guided fine-needle aspiration cytology (EUS-FNAC) in patients of tubercular uveitis. DESIGN: Interventional case series Methods: Thirty patients suspected of tubercular uveitis that underwent EUS-FNAC were enrolled in the study. The patient details recorded were age, gender, systemic history, ocular complaints and clinical manifestations. The details of the investigations - skin test, X-Ray chest, CECT (contrast enhanced computed tomography) of chest and findings on EUS-FNAC were also recorded...
November 20, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29154313/automatic-segmentation-of-tumors-in-b-mode-breast-ultrasound-images-using-information-gain-based-neutrosophic-clustering
#6
Madan Lal, Lakhwinder Kaur, Savita Gupta
BACKGROUND: Since breast ultrasound images are of low contrast, contain inherent noise and shadowing effect due to its imaging process, segmentation of breast tumors depicting ultrasound image is a challenging task. Thus, a robust breast ultrasound image segmentation technique is inevitable. OBJECTIVE: To develop an automatic lesion segmentation technique and scheme for breast ultrasound images. METHODS: First, the scheme automatically detects the suspicious tumor region of interest and dscards the unwanted complex background regions...
November 16, 2017: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/29153901/use-of-5-alpha-reductase-inhibitors-as-alternatives-to-luteinizing-hormone-releasing-hormone-lhrh-analogs-or-anti-androgens-for-prostate-downsizing-before-brachytherapy
#7
Hee Joon Bae, Omar Mian, Dhananjay Vaidya, Theodore L DeWeese, Daniel Y Song
INTRODUCTION: Prostate hypertrophy, median lobe hypertrophy, and pubic arch interference (PAI) are relative contraindications to brachytherapy because of potential morbidity and technical considerations. GnRH analogs or non-steroidal anti-androgens are currently utilized to achieve prostatic downsizing prior to brachytherapy. However, such agents have been associated with effects on body habitus, metabolism, and quality of life. In contrast, 5-alpha reductase inhibitors (5-ARI) are far less frequently associated with these morbidities...
October 10, 2017: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29153371/liver-metastases-detection-and-staging
#8
REVIEW
Therese Lincke, Christoph J Zech
The liver is more often involved with metastatic disease than primary liver tumors. The accurate detection and characterization of liver metastases are crucial since patient management depends on it. The imaging options, mainly consisting of contrast-enhanced ultrasound (CEUS), multidetector computed tomography (CT), magnetic resonance imaging (MRI) with diffusion-weighted imaging (DWI), extra-cellular contrast media and liver-specific contrast media as well as positron emission tomography/computed tomography (PET/CT), are constantly evolving...
December 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29151981/cellular-uptake-of-plain-and-spion-modified-microbubbles-for-potential-use-in-molecular-imaging
#9
Mona Ahmed, Barbara Cerroni, Anton Razuvaev, Johan Härmark, Gaio Paradossi, Kenneth Caidahl, Björn Gustafsson
Introduction: Both diagnostic ultrasound (US) and magnetic resonance imaging (MRI) accuracy can be improved by using contrast enhancement. For US gas-filled microbubbles (MBs) or silica nanoparticles (SiNPs), and for MRI superparamagnetic or paramagnetic agents, contribute to this. However, interactions of MBs with the vascular wall and cells are not fully known for all contrast media. Methods: We studied the in vitro interactions between three types of non-targeted air-filled MBs with a polyvinyl-alcohol shell and murine macrophages or endothelial cells...
2017: Cellular and Molecular Bioengineering
https://www.readbyqxmd.com/read/29151131/contrast-enhanced-ultrasound-of-the-liver-technical-and-lexicon-recommendations-from-the-acr-ceus-li-rads-working-group
#10
Andrej Lyshchik, Yuko Kono, Christoph F Dietrich, Hyun-Jung Jang, Tae Kyoung Kim, Fabio Piscaglia, Alexander Vezeridis, Juergen K Willmann, Stephanie R Wilson
Contrast-enhanced ultrasound (CEUS) is a specific form of ultrasound imaging performed with intravenous administration of microbubble contrast agents. It has been extensively used for liver tumor characterization and was recently added to the American College of Radiology Liver Imaging Reporting and Data System (CEUS LI-RADS). This paper describes technical recommendations for successful liver CEUS lesion characterization, and provides imaging protocol and Lexicon of imaging findings.
November 18, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29148219/breaking-free-from-vascular-confinement-status-and-prospects-for-submicron-ultrasound-contrast-agents
#11
REVIEW
Carly Pellow, David E Goertz, Gang Zheng
The development of encapsulated microbubbles (~1-6 μm) has expanded the utility of ultrasound from soft tissue anatomical imaging to not only functional intravascular imaging, but therapeutic interventions, with compelling studies of elicited biological effects. The large diameter of these bubbles has confined their utility to the vasculature, but converging interdisciplinary research pathways are giving rise to new submicron ultrasound contrast agents capable of extending their effects beyond the vascular compartment...
November 17, 2017: Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology
https://www.readbyqxmd.com/read/29147077/application-of-breast-ultrasound-elastography-to-differentiate-intracapsular-collection-from-silicone-induced-granuloma-of-breast-implant-capsule-complementarily-to-contrast-enhanced-breast-magnetic-resonance-imaging
#12
Eduardo de Faria Castro Fleury, Ana Claudia Gianini, Veronica Ayres, Luciana C Ramalho, Decio Roveda, Vilmar Marques de Oliveira
Background: To determine whether there is correlation between magnetic resonance imaging (MRI) findings and breast elastography to differentiate seroma/hematoma from silicone-induced granuloma of breast implant capsule (SIGBIC). Methods: Prospective study of 99 patients with breast implants submitted to breast MRI during the period from February 1 to May 1, 2017. Patients who present MRI findings of seroma/hematoma or SIGBIC were submitted to a complementary ultrasound elastography study to evaluate the correlation of the results...
2017: Breast Cancer: Basic and Clinical Research
https://www.readbyqxmd.com/read/29146416/fulminant-adrenergic-myocarditis-complicated-by-pulmonary-edema-cardiogenic-shock-and-cardiac-arrest
#13
Pawel Rostoff, Bohdan Nessler, Patrycja Pikul, Karolina Golinska-Grzybala, Tomasz Miszalski-Jamka, Jadwiga Nessler
Adrenergic myocarditis is an uncommon presentation of pheochromocytoma and extremely rare cause of de novo acute heart failure (AHF). We present a case of a 31-year-old Caucasian woman with a history of hypertension and recurrent occipital headaches who was admitted to the emergency department due to severe de novo AHF presenting as pulmonary edema and cardiogenic shock. During the hospital admission the patient experienced asystolic cardiac arrest and was successfully resuscitated, intubated, and mechanically ventilated...
November 10, 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29143912/determination-of-splenomegaly-by-coronal-oblique-length-on-ct
#14
Serra Ozbal Gunes, Yeliz Akturk
PURPOSE: The aims of this study were (a) to determine whether a coronal oblique length (COL) > 12 cm, which is often used to detect splenomegaly (SM) on ultrasound, can be used as a marker of SM on computed tomography (CT), (b) to compare the diagnostic accuracy of COL with other unidimensional linear measurements (ULM) in identifying SM, (c) to determine which ULM most closely correlates with splenic volume (SVol) according to the splenic index on CT, (d) to assess the relationship between SVol and patient's gender, age and body parameters (height, weight), and (e) to determine whether there is a difference between non-contrast-enhanced and contrast-enhanced CT images in identifying SM...
November 16, 2017: Japanese Journal of Radiology
https://www.readbyqxmd.com/read/29142969/elucidation-of-renal-scars-in-children-with%C3%A2-vesicoureteral-reflux-using-contrast-enhanced-ultrasound-a-pilot%C3%A2-study
#15
David S Hains, Harris L Cohen, M Beth McCarville, Ellen E Ellison, Amy Huffman, Stacey Glass, Aslam H Qureshi, Keith R Pierce, Ashlyn L Cahill, Ashley Dixon, Noel Delos Santos
Introduction: Vesicoureteral reflux is a common disorder in children but can result in kidney scarring following acute pyelonephritis. The gold standard diagnostic to detect renal scars in children is (99m)Tc-dimercaptosuccinic acid (DMSA) scintigraphy. DMSA has a number of limitations including radiation exposure, need for sedation, and radiotracer supply shortages. Contrast-enhanced ultrasound (CEUS) is a technique whereby biocompatible microspheres of inert gas are administered i.v...
May 2017: KI Reports
https://www.readbyqxmd.com/read/29142190/detection-of-atherosclerotic-plaques-in-the-rabbit-aorta-using-ultrasound-microbubbles-conjugated-to-interleukin-18-antibodies
#16
Zhen-Zhen Jiang, Xia-Tian Liu, Cai-Ye Ma, Cong He, Xing-Yun Li, Chuan-Lin Hou, Zu-Sheng Cheng, Guo-Yuan Xia
BACKGROUND The purpose of the study was to investigate the ability of microbubbles (MBs) targeting interleukin-18 (IL-18) to detect plaques in a rabbit atherosclerotic plaque model. MATERIAL AND METHODS A rabbit atherosclerotic plaque model was established. The locations of the atherosclerotic plaques were verified by two-dimensional scanning and color Doppler flow imaging. An IL-18 antibody was conjugated to naked MBs (MBc) using the biotin-streptavidin conjugation method, resulting in the formation of MBIL-18...
November 16, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29141515/mri-powered-biomedical-devices
#17
Sierra Hovet, Hongliang Ren, Sheng Xu, Bradford Wood, Junichi Tokuda, Zion Tsz Ho Tse
Magnetic resonance imaging (MRI) is beneficial for imaging-guided procedures because it provides higher resolution images and better soft tissue contrast than computed tomography (CT), ultrasound, and X-ray. MRI can be used to streamline diagnostics and treatment because it does not require patients to be repositioned between scans of different areas of the body. It is even possible to use MRI to visualize, power, and control medical devices inside the human body to access remote locations and perform minimally invasive procedures...
November 16, 2017: Minimally Invasive Therapy & Allied Technologies: MITAT
https://www.readbyqxmd.com/read/29141114/ph-ultrasound-dual-responsive-gas-generator-for-ultrasound-imaging-guided-therapeutic-inertial-cavitation-and-sonodynamic-therapy
#18
Qianhua Feng, Wanxia Zhang, Xuemei Yang, Yuzhen Li, Yongwei Hao, Hongling Zhang, Lin Hou, Zhenzhong Zhang
Herein, a pH/ultrasound dual-responsive gas generator is reported, which is based on mesoporous calcium carbonate (MCC) nanoparticles by loading sonosensitizer (hematoporphyrin monomethyl ether (HMME)) and modifying surface hyaluronic acid (HA). After pinpointing tumor regions with prominent targeting efficiency, HMME/MCC-HA decomposes instantaneously under the cotriggering of tumoral inherent acidic condition and ultrasound (US) irradiation, concurrently accompanying with CO2 generation and HMME release with spatial/temporal resolution...
November 15, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/29140316/hybrid-system-for-in-vivo-epifluorescence-and-4d-optoacoustic-imaging
#19
Zhenyue Chen, Xosé Luis Deán-Ben, Sven Gottschalk, Daniel Razansky
Epifluorescence imaging is widely used in cell and molecular biology due to its excellent sensitivity, contrast, and ease of implementation. Optoacoustic imaging has been shown to deliver a highly complementary and unique set of capabilities for biological discovery, such as high spatial resolution in noninvasive deep tissue observations, fast volumetric imaging capacity, and spectrally enriched contrast. In this Letter, we report on a hybrid system combining planar fluorescence and real-time volumetric four-dimensional optoacoustic imaging by means of a fiberscope integrated within a handheld hemispherical ultrasound detection array...
November 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/29138385/parameters-for-contrast-enhanced-ultrasound-ceus-of-enlarged-superficial-lymph-nodes-for-the-evaluation-of-therapeutic-response-in-lymphoma-a-preliminary-study
#20
Lei Xin, Zhimei Yan, Xiaojuan Zhang, Yichen Zang, Zhaoyan Ding, Hongwei Xue, Cheng Zhao
BACKGROUND The aims of this preliminary study were to evaluate contrast-enhanced ultrasound (CEUS) imaging and the therapeutic response of enlarged superficial lymph nodes in patients with lymphoma before and after chemotherapy and to determine the most useful CEUS response parameters. MATERIAL AND METHODS Forty-three patients with lymphoma, with 43 enlarged superficial lymph nodes, underwent CEUS and conventional ultrasound (US), before treatment and after the first three cycles of chemotherapy. Clinical responses included overall response (OR) and no response (NR)...
November 15, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
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