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https://www.readbyqxmd.com/read/29453409/a-potential-prognostic-long-noncoding-rna-signature-to-predict-recurrence-among-er-positive-breast-cancer-patients-treated-with-tamoxifen
#1
Kang Wang, Jie Li, Yong-Fu Xiong, Zhen Zeng, Xiang Zhang, Hong-Yuan Li
Limited predictable long noncoding RNA (lncRNA) signature was reported in tamoxifen resistance among estrogen receptor (ER)-positive breast cancer (BC) patients. The aim of this study was to identify and assess prognostic lncRNA signature to predict recurrence among ER-positive BC patients treated with tamoxifen. Cohorts from Gene Expression Omnibus (GEO) (n = 298) and The Cancer Genome Atlas (TCGA) (n = 160) were defined as training and validation cohort, respectively. BC relapse associated lnRNAs was identify within training cohort, and the predictable value of recurrence was assessed in both cohorts...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29452180/the-m-maze-task-an-automated-method-for-studying-fear-memory-in-rats-exposed-to-protracted-aversive-conditioning
#2
Rimenez R Souza, Nicole M Robertson, David T Pruitt, Lindsey Noble, Eric C Meyers, Phillip A Gonzales, Nathaniel P Bleker, Holle L Carey, Seth A Hays, Michael P Kilgard, Christa K McIntyre, Robert L Rennaker
BACKGROUND: Fear conditioning (FC) in rodents is the most used animal model to investigate the neurobiology of posttraumatic stress disorder (PTSD). Although research using FC has generated a better understanding of fear memories, studies often rely on mild or moderate FC training and behavioral analysis generally focuses on measuring freezing responses within few test sessions. NEW METHOD: We introduce the M-Maze task, a system to measures extinction of conditioned fear using suppression of operant behavior...
February 13, 2018: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/29452135/evidence-based-exercise-recommendations-to-reduce-hepatic-fat-content-in-youth-a-systematic-review-and-meta-analysis
#3
REVIEW
María Medrano, Cristina Cadenas-Sanchez, Celia Álvarez-Bueno, Iván Cavero-Redondo, Jonatan R Ruiz, Francisco B Ortega, Idoia Labayen
The main purposes of this study were to elucidate the effects of supervised-exercise training (ET) interventions on hepatic fat content and on non-alcoholic fatty liver disease (NAFLD) prevalence in children and adolescents and to provide information about the optimal ET prescription (type, intensity, volume, and frequency) needed to reduce hepatic fat content in youths. Supervised-ET interventions performed in children and adolescents (6-19 years) that provided results of exercise effects on hepatic fat content or NAFLD prevalence were included...
February 13, 2018: Progress in Cardiovascular Diseases
https://www.readbyqxmd.com/read/29451065/shoulder-and-arm-muscle-activity-during-elastic-band-exercises-performed-in-a-hospital-bed
#4
Sebastian Skals, Jonas Vinstrup, Emil Sundstrup, Markus D Jakobsen, Christoffer H Andersen, Lars L Andersen
OBJECTIVE: Muscle atrophy is a common side-effect of bed rest during hospitalization. However, resistance training may minimize or even prevent these complications. Therefore, we evaluated the efficiency of four upper-body elastic resistance exercises that could be performed while lying or sitting in a hospital bed. METHODS: Twenty-two healthy subjects performed three repetitions of each exercise in a supine and seated position with a perceived intensity of 3 (low) and 8 (high) on the Borg CR10 Scale...
February 16, 2018: Physician and Sportsmedicine
https://www.readbyqxmd.com/read/29450404/reengineering-deep-brain-stimulation-for-movement-disorders-emerging-technologies
#5
Aysegul Gunduz, Kelly D Foote, Michael S Okun
Deep brain stimulation (DBS) is a neurosurgical technique, which consists of continuous delivery of an electrical pulse through chronically implanted electrodes connected to a neurostimulator, programmable in amplitude, pulse width, frequency, and stimulation channel. DBS is a promising treatment option for addressing severe and drug-resistant movement disorders. The success of DBS therapy is a combination of surgical implantation techniques, device technology, and clinical programming strategies. Changes in device settings require highly trained and experienced clinicians to achieve maximal therapeutic benefit for each targeted symptom, and optimization of stimulation parameters can take many visits...
December 2017: Current Opinion in Biomedical Engineering
https://www.readbyqxmd.com/read/29448855/acute-effects-of-blood-flow-restriction-on-exercise-induced-free-radical-production-in-young-and-healthy-subjects
#6
Christoph Centner, Denise Zdzieblik, Patrick Dressler, Bruno Fink, Albert Gollhofer, Daniel König
The main purpose of this study was to investigate the acute local and systemic effects of low-load resistance exercise (30% 1RM) with partial vascular occlusion on exercise-induced free radical production and to compare these effects with other established training methods. Fifteen young and healthy males (25 ± 3 years) performed the following four sessions in a counterbalanced order on separate days: low-load resistance exercise (LI: 30% 1RM), low-load resistance exercise with blood flow restriction (LIBR: 30% 1RM), high-load resistance exercise (HI: 80% 1RM) and an additional session without exercise but blood flow restriction only (BR)...
February 16, 2018: Free Radical Research
https://www.readbyqxmd.com/read/29447936/inducing-hypertrophic-effects-of-type-i-skeletal-muscle-fibers-a-hypothetical-role-of-time-under-load-in-resistance-training-aimed-at-muscular-hypertrophy
#7
Jozo Grgic, Jan Homolak, Pavle Mikulic, Javier Botella, Brad J Schoenfeld
An emerging body of evidence is starting to suggest that the hypertrophy of skeletal muscle fibers might be load specific. In other words, it may be that resistance training with high loads (i.e., ≥60% of 1 repetition maximum [RM]) emphasizes a greater growth of type II muscle fibers, while resistance training with low loads (i.e., <60% of 1RM) might primarily augment hypertrophy of type I muscle fibers. Type I and type II muscle fibers possess certain distinct characteristics, with type II muscle fibers having faster calcium kinetics, faster shortening velocities, and ability to generate more power than type I muscle fibers...
March 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29444538/-effects-of-judo-specific-resistance-training-on-kinetic-and-electromyographic-parameters-of-pulling-exercises-in-judo-athletes
#8
Norman Helm, Olaf Prieske, Thomas Muehlbauer, Tom Krüger, Urs Granacher
BACKGROUND: In judo, rapid force production during pulling movements is an important component of athletic performance, which is why this capacity needs to be specifically exercised in judo. This study aimed at examining the effects of a judo-specific resistance training program using a judo ergometer system (PTJ) versus a traditional resistance training regime using a partner (PTP) on kinetics and muscle activity of judo-specific pulling exercises. METHOD: Twenty-four male judo athletes (age: 22 ± 4 years, training experience: 15 ± 3 years) were randomly assigned to two groups...
February 14, 2018: Sportverletzung Sportschaden: Organ der Gesellschaft Für Orthopädisch-Traumatologische Sportmedizin
https://www.readbyqxmd.com/read/29444181/correction-early-and-later-phases-satellite-cell-responses-and-myonuclear-content-with-resistance-training-in-young-men
#9
(no author information available yet)
[This corrects the article DOI: 10.1371/journal.pone.0191039.].
2018: PloS One
https://www.readbyqxmd.com/read/29443549/endurance-exercise-training-and-high-fat-diet-differentially-affect-composition-of-diacylglycerol-molecular-species-in-rat-skeletal-muscle
#10
Noriaki Kawanishi, Kana Takagi, Hyeon-Cheol Lee, Daiki Nakano, Toshiaki Okuno, Takehiko Yokomizo, Shuichi Machida
Insulin resistance of peripheral muscle is implicated in the aetiology of metabolic syndrome in obesity. Although accumulation of glycerolipids, such as triacylglycerol and diacylglycerol (DAG), in muscle contributes to insulin resistance in obese individuals, endurance-trained athletes also have higher glycerolipid levels but normal insulin sensitivity. We hypothesised that the difference in insulin sensitivity of skeletal muscle between athletes and obese individuals stems from changes in fatty acid composition of accumulated lipids...
February 14, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29443103/paradigms-of-lower-extremity-electrical-stimulation-training-after-spinal-cord-injury
#11
Ashraf S Gorgey, Refka E Khalil, Robert M Lester, Gary A Dudley, David R Gater
Skeletal muscle atrophy, increased adiposity and reduced physical activity are key changes observed after spinal cord injury (SCI) and are associated with numerous cardiometabolic health consequences. These changes are likely to increase the risk of developing chronic secondary conditions and impact the quality of life in persons with SCI. Surface neuromuscular electrical stimulation evoked resistance training (NMES-RT) was developed as a strategy to attenuate the process of skeletal muscle atrophy, decrease ectopic adiposity, improve insulin sensitivity and enhance mitochondrial capacity...
February 1, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29440695/combination-of-nutritional-polyphenols-supplementation-with-exercise-training-counteracts-insulin-resistance-and-improves-endurance-in-high-fat-diet-induced-obese-rats
#12
Karen Lambert, Marie Hokayem, Claire Thomas, Odile Fabre, Cécile Cassan, Annick Bourret, Florence Bernex, Christine Feuillet-Coudray, Cécile Notarnicola, Jacques Mercier, Antoine Avignon, Catherine Bisbal
Separately, polyphenols and exercise are known to prevent insulin resistance (IR) but their combined curative effects on established obesity and IR require further investigation. Therefore, we compared the metabolic effects of a combination of exercise and grape polyphenols supplementation in obese IR rats with high-fat diet (EXOPP) to the effect of high-fat diet alone (HF) or with a nutritional supplementation of grape polyphenols (PP) or with endurance exercise (EXO) during 8 wks. We observed an improvement of systemic and skeletal muscle insulin sensitivity in EXO and EXOPP rats...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29440149/cancer-cachexia-rationale-for-the-menac-multimodal-exercise-nutrition-and-anti-inflammatory-medication-for-cachexia-trial
#13
REVIEW
Tora S Solheim, Barry J A Laird, Trude R Balstad, Asta Bye, Guro Stene, Vickie Baracos, Florian Strasser, Gareth Griffiths, Matthew Maddocks, Marie Fallon, Stein Kaasa, Kenneth Fearon
Cancer cachexia is a multifactorial syndrome characterised by an ongoing loss of skeletal muscle mass that cannot be fully reversed by conventional nutritional support alone. Cachexia has a high prevalence in cancer and a major impact on patient physical function, morbidity and mortality. Despite the consequences of cachexia, there is no licensed treatment for cachexia and no accepted standard of care. It has been argued that the multifactorial genesis of cachexia lends itself to therapeutic targeting through a multimodal treatment...
February 9, 2018: BMJ Supportive & Palliative Care
https://www.readbyqxmd.com/read/29439005/randomised-controlled-trial-using-a-theory-based-m-health-intervention-to-improve-physical-activity-and-sleep-health-in-adults-the-synergy-study-protocol
#14
Beatrice Murawski, Ronald C Plotnikoff, Anna T Rayward, Corneel Vandelanotte, Wendy J Brown, Mitch J Duncan
INTRODUCTION: There is a need to reduce physical inactivity and poor sleep health in the adult population to decrease chronic disease rates and the associated burden. Given the high prevalence of these risk behaviours, effective interventions with potential for wide reach are warranted. METHODS AND ANALYSIS: The aim of this two-arm RCT will be to test the effect of a three month personalised mobile app intervention on two main outcomes: minutes of moderate-to-vigorous-intensity physical activity and overall sleep quality...
February 8, 2018: BMJ Open
https://www.readbyqxmd.com/read/29438735/high-intensity-stretch-shortening-contraction-training-modifies-responsivity-of-skeletal-muscle-in-old-male-rats
#15
Erik P Rader, Marshall A Naimo, James Ensey, Brent A Baker
Utilization of high-intensity resistance training to counter age-related sarcopenia is currently debated because of the potential for maladaptation when training design is inappropriate. Training design is problematic because the influence of various loading variables (e.g. contraction mode, repetition number, and training frequency) is still not well characterized at old age. To address this in a precisely controlled manner, we developed a rodent model of high-intensity training consisting of maximally-activated stretch-shortening contractions (SSCs), contractions typical during resistance training...
February 10, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29438584/regional-regulation-of-focal-adhesion-kinase-after-concentric-and-eccentric-loading-is-related-to-remodeling-of-human-skeletal-muscle
#16
Martino V Franchi, Severin Ruoss, Paola Valdivieso, Kyle W Mitchell, Kenneth Smith, Philip J Atherton, Marco V Narici, Martin Flück
AIMS: We assessed focal adhesion kinase (FAK) response to concentric (CON) versus eccentric (ECC) resistance training (RT) at two vastus lateralis (VL) sites, and the relationships between FAK, muscle protein synthesis (MPS), and morphological remodeling. METHODS: Six young males trained both legs unilaterally 3 times/week for 8 weeks; one leg performed CON RT, the contralateral performed ECC RT. Muscle biopsies were collected after training from VL midbelly (MID) and distal (Distal) sites at 0, 4, 8 weeks...
February 13, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29438547/effectiveness-of-general-practitioner-online-training-and-an-information-booklet-for-parents-on-antibiotic-prescribing-for-children-with-respiratory-tract-infection-in-primary-care-a-cluster-randomized-controlled-trial
#17
Anne R J Dekker, Theo J M Verheij, Berna D L Broekhuizen, Christopher C Butler, Jochen W L Cals, Nick A Francis, Paul Little, Elisabeth A M Sanders, Lucy Yardley, Nicolaas P A Zuithoff, Alike W van der Velden
Objectives: Antibiotics are too often prescribed in childhood respiratory tract infection (RTI), despite limited effectiveness, potential side effects and bacterial resistance. We aimed to reduce antibiotic prescribing for children with RTI by online training for general practitioners (GPs) and information for parents. Methods: A pragmatic cluster randomized controlled trial in primary care. The intervention consisted of online training for GPs and an information booklet for parents...
February 9, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29434550/select-skeletal-muscle-mrnas-related-to-exercise-adaptation-are-minimally-affected-by-different-pre-exercise-meals-that-differ-in-macronutrient-profile
#18
Pim Knuiman, Maria T E Hopman, Jeroen A Wouters, Marco Mensink
Background: Substantial research has been done on the impact of carbohydrate and fat availability on endurance exercise adaptation, though its role in the acute adaptive response to resistance exercise has yet to be fully characterized. Purpose: We aimed to assess the effects of a pre-resistance exercise isocaloric mixed meal containing different amounts of carbohydrates and fat, on post-resistance exercise gene expression associated with muscle adaptation. Methods: Thirteen young (age 21.2 ± 1.6 year), recreationally trained (VO 2max 51...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29434456/does-neuromuscular-electrical-stimulation-therapy-increase-voluntary-muscle-strength-after-spinal-cord-injury-a-systematic-review
#19
Gabriel Ribeiro de Freitas, Camila Szpoganicz, Jocemar Ilha
Background: Physical therapists frequently use neuromuscular electrical stimulation (NMES) therapy in an effort to increase the voluntary strength of partially paralyzed muscles in people with spinal cord injury (SCI), but it is not clear whether this treatment is effective. Objective: To determine the effectiveness of NMES for increasing voluntary strength in the partially paralyzed muscles of people with SCI. Methods: A systematic review of scientific literature was conducted in MEDLINE, CINAHL, PEDro, ScienceDirect, and Embase...
2018: Topics in Spinal Cord Injury Rehabilitation
https://www.readbyqxmd.com/read/29432326/exercise-improves-physical-activity-and-comorbidities-in-obese-adults-with-asthma
#20
Patrícia Duarte Freitas, Aline Grandi Silva, Palmira Gabriele Ferreira, Analuci da Silva, João Marcos Salge, Regina Maria Carvalho-Pinto, Alberto Cukier, Claudia M Brito, Marcio C Mancini, Celso R F Carvalho
INTRODUCTION: Obese adults with asthma have an increased number of comorbidities and reduced daily life physical activity (DLPA), which may worsen asthma symptoms. Exercise is recommended to improve asthma outcomes; however, the benefits of exercise for psychosocial comorbidities and physical activity levels in obese adults with asthma have been poorly investigated. OBJECTIVE: To assess the effects of exercise on DLPA, asthma symptoms and psychosocial comorbidities in obese adults with asthma...
February 9, 2018: Medicine and Science in Sports and Exercise
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