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Inflammatory heart diseases

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https://www.readbyqxmd.com/read/28722106/anti-inflammatory-effects-of-exercise-role-in-diabetes-and-cardiovascular-disease
#1
REVIEW
Bente Klarlund Pedersen
BACKGROUND: Persistent inflammation is involved in the pathogenesis of chronic diseases such as type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD). AIMS: The aim of this review was to provide the reader with an update of the mechanisms whereby exercise-induced cytokines may impact cardiometabolic diseases. RESULTS: Evidence exists that interleukin (IL)-1β is involved in pancreatic β-cell damage, whereas TNF-α is a key molecule in peripheral insulin resistance...
July 19, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28718586/-adverse-events-of-biologic-therapies
#2
Gregory Fleury, Cem Gabay
Biological therapies have revolutionized the management and the outcome of patients with inflammatory rheumatic diseases. The prescription and the number of patients under biotherapies have greatly increased. Unfortunately, these treatments are occasionally accompanied by side effects usually reversible upon treatment discontinuation. Some are preventable or can be reduced, including through the screening and prevention (tuberculosis screening, vaccination…). It is important to be aware of these different side effects to adapt the prescription of biologics according to the patient's profile (history of infection, malignancy, heart failure…)...
March 8, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28714932/thrombospondins-a-role-in-cardiovascular-disease
#3
REVIEW
Dimitry A Chistiakov, Alexandra A Melnichenko, Veronika A Myasoedova, Andrey V Grechko, Alexander N Orekhov
Thrombospondins (TSPs) represent extracellular matrix (ECM) proteins belonging to the TSP family that comprises five members. All TSPs have a complex multidomain structure that permits the interaction with various partners including other ECM proteins, cytokines, receptors, growth factors, etc. Among TSPs, TSP1, TSP2, and TSP4 are the most studied and functionally tested. TSP1 possesses anti-angiogenic activity and is able to activate transforming growth factor (TGF)-β, a potent profibrotic and anti-inflammatory factor...
July 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28709692/ampk-orchestrates-an-elaborate-cascade-protecting-tissue-from-fibrosis-and-aging
#4
REVIEW
Shuai Jiang, Tian Li, Zhi Yang, Wei Yi, Shouyin Di, Yang Sun, Dongjin Wang, Yang Yang
Fibrosis is a common process characterized by excessive extracellular matrix (ECM) accumulation after inflammatory injury, which is also a crucial cause of aging. The process of fibrosis is involved in the pathogenesis of most diseases of the heart, liver, kidney, lung, and other organs/tissues. However, there are no effective therapies for this pathological alteration. Annually, fibrosis represents a huge financial burden for the USA and the world. 5'-AMP-activated protein kinase (AMPK) is a pivotal energy sensor that alleviates or delays the process of fibrogenesis...
July 11, 2017: Ageing Research Reviews
https://www.readbyqxmd.com/read/28707261/from-inflammation-to-fibrosis-molecular-and-cellular-mechanisms-of-myocardial-tissue-remodelling-and-perspectives-on-differential-treatment-opportunities
#5
REVIEW
Navin Suthahar, Wouter C Meijers, Herman H W Silljé, Rudolf A de Boer
PURPOSE OF REVIEW: In this review, we highlight the most important cellular and molecular mechanisms that contribute to cardiac inflammation and fibrosis. We also discuss the interplay between inflammation and fibrosis in various precursors of heart failure (HF) and how such mechanisms can contribute to myocardial tissue remodelling and development of HF. RECENT FINDINGS: Recently, many research articles attempt to elucidate different aspects of the interplay between inflammation and fibrosis...
July 13, 2017: Current Heart Failure Reports
https://www.readbyqxmd.com/read/28698147/rip2-deficiency-attenuates-cardiac-hypertrophy-inflammation-and-fibrosis-in-pressure-overload-induced-mice
#6
Cui-Hua Zhao, Xiang Ma, Hong-Yu Guo, Peng Li, Hong-Yang Liu
Although the pathological cardiac hypertrophy presents a leading cause of morbidity and mortality worldwide, our knowledge of the molecular mechanisms underlying the disease is still poor. Here, we reported that receptor-interacting serine/threonine-protein kinase 2 (RIP2), promoting pro-inflammatory gene expression, enhanced the pathological cardiac hypertrophy in animals. The effects of RIP2 on the cardiac hypertrophy triggered by pathological stimuli have not been fully investigated. In our study, mice were subjected to aortic banding (AB) surgery to explore the pathological, echocardiographic and molecular mechanisms...
July 8, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28691076/self-assembling-cyclic-d-l-%C3%AE-peptides-as-modulators-of-plasma-hdl-function-a-supramolecular-approach-toward-antiatherosclerotic-agents
#7
Yannan Zhao, Luke J Leman, Debra J Search, Ricardo A Garcia, David A Gordon, Bruce E Maryanoff, M Reza Ghadiri
There is great interest in developing new modes of therapy for atherosclerosis to treat coronary heart disease and stroke, particularly ones that involve modulation of high-density lipoproteins (HDLs). Here, we describe a new supramolecular chemotype for altering HDL morphology and function. Guided by rational design and SAR-driven peptide sequence enumerations, we have synthesized and determined the HDL remodeling activities of over 80 cyclic d,l-α-peptides. We have identified a few distinct sequence motifs that are effective in vitro in remodeling human and mouse plasma HDLs to increase the concentration of lipid-poor pre-beta HDLs, which are key initial acceptors of cholesterol in the reverse cholesterol transport (RCT) process, and concomitantly promote cholesterol efflux from macrophage cells...
June 28, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28690546/repeated-excessive-exercise-attenuates-the-anti-inflammatory-effects-of-exercise-in-older-men
#8
Ronni E Sahl, Peter R Andersen, Katja Gronbaek, Thomas H Morville, Mads Rosenkilde, Hanne K Rasmusen, Steen S Poulsen, Clara Prats, Flemming Dela, Jørn W Helge
Introduction/Purpose: A number of studies have investigated the effect of training with a moderate exercise dose (3-6 h/weekly) on the inflammatory profile in blood, and the data are inconsistent. Cross-sectional studies indicate a positive effect of physical activity level on inflammation levels and risk of metabolic disease. However, it is not clear whether this may be dose dependent and if very prolonged repeated exercise therefore may be beneficial for low-grade inflammation. Based on this we studied how excessive repeated prolonged exercise influenced low-grade inflammation and adipose tissue anti-inflammatory macrophage content in six older male recreationally trained cyclists...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28689586/cardiovascular-manifestations-of-hepatitis-c-virus
#9
REVIEW
Nicolas Goossens, Francesco Negro
Hepatitis C virus (HCV) infection is a prevalent condition associated with numerous extrahepatic manifestations. Epidemiologic studies have found that HCV is associated with increased cardiovascular morbidity and mortality, in particular with carotid atherosclerosis, cerebrovascular events, and coronary heart disease. The mechanisms involved encompass a chronic systemic inflammatory state, insulin resistance, and a potential, direct infection of the vascular endothelium. Sustained virologic response with interferon-based regimens is associated with reduced cardiovascular events, although this must be validated with newer direct-acting antivirals...
August 2017: Clinics in Liver Disease
https://www.readbyqxmd.com/read/28688892/vascular-ossification-pathology-mechanisms-and-clinical-implications
#10
Michael A Fuery, Lusha Liang, Frederick S Kaplan, Emile R Mohler
In recent years, the mechanisms and clinical significance of vascular calcification have been increasingly investigated. For over a century, however, pathologists have recognized that vascular calcification is a form of heterotopic ossification. In this review, we aim to describe the pathology and molecular processes of vascular ossification, to characterize its clinical significance and treatment options, and to elucidate areas that require further investigation. The molecular mechanisms of vascular ossification involve the activation of regulators including bone morphogenic proteins and chondrogenic transcription factors and the loss of mineralization inhibitors like fetuin-A and pyrophosphate...
July 5, 2017: Bone
https://www.readbyqxmd.com/read/28687233/overview-of-immune-abnormalities-in-lysosomal-storage-disorders
#11
REVIEW
Donato Rigante, Clelia Cipolla, Umberto Basile, Francesca Gulli, Maria Cristina Savastano
The critical relevance of the lysosomal compartment for normal cellular function can be proved by numbering the clinical phenotypes that arise in lysosomal storage disorders (LSDs), a group of around 70 different monogenic autosomal or X-linked syndromes, caused by specific lysosomal enzyme deficiencies: all LSDs are characterized by progressive accumulation of heterogeneous biologic materials in the lysosomes of various parts of the body such as viscera, skeleton, skin, heart, and central nervous system. At least a fraction of LSDs has been associated with mixed abnormalities involving the immune system, while some patients with LSDs may result more prone to autoimmune phenomena...
July 4, 2017: Immunology Letters
https://www.readbyqxmd.com/read/28687076/baccaurea-angulata-fruit-juice-reduces-atherosclerotic-lesions-in-diet-induced-hypercholesterolemic-rabbits
#12
Muhammad Ibrahim, Idris Adewale Ahmed, Maryam Abimbola Mikail, Afeez Adekunle Ishola, Samsul Draman, Muhammad Lokman Md Isa, Afzan Mat Yusof
BACKGROUND: Atherosclerosis is the most common disease of large and medium-sized arteries linked to oxidative stress, dyslipidemia as well as chronic inflammation. The aim of this study was to evaluate the potential health benefits of Baccaurea angulata (BA) fruit juice on the aorta of diet-induced hypercholesterolemic rabbits, to detect an accumulation of fatty streak and evaluate the percentage of atherosclerotic lesion accrued. METHODS: Thirty-five healthy male adults New Zealand White rabbits were assigned to seven different groups...
July 7, 2017: Lipids in Health and Disease
https://www.readbyqxmd.com/read/28684396/cardiac-stress-and-inflammatory-markers-as-predictors-of-heart-failure-in-patients-with-type-2-diabetes-the-advance-trial
#13
Toshiaki Ohkuma, Min Jun, Mark Woodward, Sophia Zoungas, Mark E Cooper, Diederick E Grobbee, Pavel Hamet, Giuseppe Mancia, Bryan Williams, Paul Welsh, Naveed Sattar, Jonathan E Shaw, Kazem Rahimi, John Chalmers
OBJECTIVE: This study examined the individual and combined effect of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high-sensitivity cardiac troponin T (hs-cTnT), interleukin-6 (IL-6), and hs-CRP on the prediction of heart failure incidence or progression in patients with type 2 diabetes. RESEARCH DESIGN AND METHODS: A nested case-cohort study was conducted in 3,098 participants with type 2 diabetes in the Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation (ADVANCE) trial...
July 6, 2017: Diabetes Care
https://www.readbyqxmd.com/read/28684235/cardioprotective-time-window-of-penehyclidine-hydrochloride-postconditioning-a-rat-study
#14
Hongbao Tan, Duomao Lin, Zhaoqi Wang, Yanli Yang, Jun Ma
Pharmacological postconditioning offers a clinical perspective for all patients with ischemic heart disease. Penehyclidine hydrochloride (PHC) is a new type of anticholinergic drug. We previously reported that PHC preconditioning protects against I/R injury in rat hearts in vivo. Ischemic heart disease often occurs suddenly, so postconditioning is more significant than preconditioning. However, studies evaluating myocardial protective effects of PHC postconditioning are unavailable. We explored the effects and time-window of cardioprotection of PHC postconditioning in myocardial I/R injury...
July 3, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28683166/multi-biomarker-analysis-in-patients-with-acute-myocardial-infarction
#15
Christiana Schernthaner, Michael Lichtenauer, Bernhard Wernly, Vera Paar, Rudin Pistulli, Ilonka Rohm, Christian Jung, Hans-Reiner Figulla, Attila Yilmaz, Janne Cadamuro, Elisabeth Haschke-Becher, John Pernow, P Christian Schulze, Uta C Hoppe, Daniel Kretzschmar
BACKGROUND: Novel biomarkers representing different pathobiological pathways and their role in patients with acute myocardial infarction (AMI) were studied. METHODS: We retrospectively analyzed serum levels of soluble suppression of tumorigenicity (sST2), growth-differentiation factor-15 (GDF-15), soluble urokinase plasminogen activator receptor (suPAR), heart-type fatty acid-binding protein (H-FABP) and plasma fetuin A in blood of patients with AMI (STEMI, n=61; NSTEMI, n=57) compared to controls with excluded coronary artery disease (n=76)...
July 6, 2017: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28680407/cardiac-ion-channel-regulation-in-obesity-and-the-metabolic-syndrome-relevance-to-long-qt-syndrome-and-atrial-fibrillation
#16
REVIEW
Ademuyiwa S Aromolaran, Mohamed Boutjdir
Obesity and its associated metabolic dysregulation leading to metabolic syndrome is an epidemic that poses a significant public health problem. More than one-third of the world population is overweight or obese leading to enhanced risk of cardiovascular disease (CVD) incidence and mortality. Obesity predisposes to atrial fibrillation, ventricular, and supraventricular arrhythmias; conditions that are underlain by dysfunction in electrical activity of the heart. To date, current therapeutic options for cardiomyopathy of obesity are limited, suggesting that there is considerable room for development of therapeutic interventions with novel mechanisms of action that will help normalize rhythm in obese patients...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28679294/inflammation-in-heart-failure-known-knowns-and-unknown-unknowns
#17
Giuseppe Cocco, Paul Jerie, Philip Amiet, Stefano Pandolfi
The review deals with inflammation in heart failure (HF). Many data show that systemic inflammation is frequent in HF and implicate that inflammation contributes to damage and dysfunction of the cardiovascular system. Areas Covered: Experimental data have been mainly obtained in acute laboratory animal models. It is questionable whether animals' data can be translated into clinical settings with patients with chronic HF who have concomitant pathologies. The idea of a common inflammatory pathway that characterizes all different forms of clinical HF is unrealistic...
July 6, 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28675488/eicosapentaenoic-acid-and-docosahexaenoic-acid-containing-supplements-modulate-risk-factors-for-cardiovascular-disease-a-meta-analysis-of-randomised-placebo-control-human-clinical-trials
#18
S AbuMweis, S Jew, R Tayyem, L Agraib
BACKGROUND: Over 200 clinical trials have examined the effect of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) supplements on risk factors associated with cardiovascular disease. However, an updated analysis of the evidence is lacking. The aim of the present meta-analysis was to quantify the effect of supplements containing EPA and DHA on risk factors for cardiovascular disease. METHODS: An analysis was carried on 171 clinical trials with acceptable quality (Jadad score ≥3) that were identified from a comprehensive electronic search strategy of two databases (Pubmed and Cochrane Library)...
July 4, 2017: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
https://www.readbyqxmd.com/read/28675268/-news-about-pericardial-diseases-in-2016
#19
Baris Karpuz, Valèrie Duchatelle, Maxime Tapponnier, Raluca Alexe, Christophe Sierro, Grègoire Girod
The European Society of Cardiology published in 2015 the new Guidelines on the management of pericardial diseases. Based on experts' opinions and recent clinical studies of respectable size, the new guidelines thoroughly revisit the criteria for hospitalization and precisely define severe cases. Another highlight regards medication. From now, first-line medical therapy should include the association of colchicine to the traditional non steroidal anti-inflammatory drugs or aspirin. The bi-therapy is recommended as soon as the first episode of pericarditis, for duration of 3 months...
September 7, 2016: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28674622/use-of-non-steroidal-anti-inflammatory-drugs-in-us-adults-changes-over-time-and-by-demographic
#20
Jennifer S Davis, Hwa Young Lee, Jihye Kim, Shailesh M Advani, Ho-Lan Peng, Emilyn Banfield, Ernest T Hawk, Shine Chang, Alexis C Frazier-Wood
OBJECTIVE: Aspirin and non-aspirin non-steroidal anti-inflammatory drugs (NSAIDs) are preventive against cardiovascular disease (CVD) and several cancer types, but long-term use has been associated with significant health risks, resulting in conflicting recommendations on NSAID use for prevention of CVD and cancer. Previous research indicates that aspirin use increases with age and CVD risk factors and that a large percentage of the US population regularly use analgesics, including NSAIDs, but there has not been a recent, in-depth assessment of NSAID use prevalence, changes in use over time or predictors of NSAID use in the USA...
2017: Open Heart
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