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https://www.readbyqxmd.com/read/28960035/lactate-parameters-predict-clinical-outcomes-in-patients-with-nonvariceal-upper-gastrointestinal-bleeding
#1
Seung Hoon Lee, Yang Won Min, Joohwan Bae, Hyuk Lee, Byung Hoon Min, Jun Haeng Lee, Poong Lyul Rhee, Jae J Kim
The predictive role of lactate in patients with nonvariceal upper gastrointestinal bleeding (NVUGIB) has been suggested. This study evaluated several lactate parameters in terms of predicting outcomes of bleeding patients and sought to establish a new scoring model by combining lactate parameters and the AIMS65 score. A total of 114 patients with NVUGIB who underwent serum lactate level testing at least twice and endoscopic hemostasis within 24 hours after admission were retrospectively analyzed. The associations between five lactate parameters and clinical outcomes were evaluated and the predictive power of lactate parameter combined AIMS65s (L-AIMS65s) and AIMS56 scoring was compared...
November 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28924593/use-of-the-over-the-scope-clip-otsc-in-non-variceal-upper-gastrointestinal-bleeding-in-patients-with-severe-cardiovascular-comorbidities-a-retrospective-study
#2
Edris Wedi, Daniel von Renteln, Susana Gonzalez, Olena Tkachenko, Carlo Jung, Sinan Orkut, Victor Roth, Selin Tumay, Juergen Hochberger
INTRODUCTION:  The over-the-scope-clip (OTSC) can potentially overcome limitations of standard clips and achieve more efficient and reliable hemostasis. Data on OTSC use for non-variceal upper gastrointestinal bleeding (NVUGIB) in patients with cardiovascular comorbidities are currently limited. PATIENTS AND METHODS:  We prospectively collected and retrospectively analyzed our database from February 2009 to September 2015 from all patients who underwent emergency endoscopy for high-risk NVUGIB in 2 academic centers and were treated with OTSC as first-line (n = 81) or second-line therapy (n = 19)...
September 2017: Endoscopy International Open
https://www.readbyqxmd.com/read/28839866/antithrombotic-drugs-and-non-variceal-bleeding-outcomes-and-risk-scoring-systems-comparison-of-glasgow-blatchford-rockall-and-charlson-scores
#3
Ali S Taha, Caroline McCloskey, Theresa Craigen, Wilson J Angerson
OBJECTIVES: Antithrombotic drugs (ATDs) cause non-variceal upper gastrointestinal bleeding (NVUGIB). Risk scoring systems have not been validated in ATD users. We compared Blatchford, Rockall and Charlson scores in predicting outcomes of NVUGIB in ATD users and controls. METHODS: A total of 2071 patients with NVUGIB were grouped into ATD users (n=851) and controls (n=1220) in a single-centre retrospective analysis. Outcomes included duration of hospital admission, the need for blood transfusion, rebleeding requiring surgery and 30-day mortality...
October 2016: Frontline Gastroenterology
https://www.readbyqxmd.com/read/28656336/multicenter-evaluation-of-first-line-endoscopic%C3%A2-treatment%C3%A2-with-the%C3%A2-otsc-in-acute-non-variceal-upper-gastrointestinal%C3%A2-bleeding-and-comparison-with-the-rockall-cohort-the-fletrock-study
#4
E Wedi, A Fischer, J Hochberger, C Jung, S Orkut, H J Richter-Schrag
INTRODUCTION: The over-the-scope clip (OTSC) overcomes limitations of standard clips and achieves a more efficient and reliable hemostasis in non-variceal upper gastrointestinal bleeding (NVUGIB). The study aims to evaluate mortality, rebleeding, and mortality after rebleeding of patients in whom the OTSC was used as the first-line endoscopic treatment (FLET) of NVUGIB. PATIENTS AND METHODS: In total, 118 patients (FLET cohort) with a median age of 73.5 years (range 29-93 years; mean (±SD) 71...
June 27, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28283314/the-progetto-nazionale-emorragia-digestiva-pned-system-vs-the-rockall-score-as-mortality-predictors-in-patients-with-nonvariceal-upper-gastrointestinal-bleeding-a-multicenter-prospective-study
#5
MULTICENTER STUDY
R Contreras-Omaña, J A Alfaro-Reynoso, C E Cruz-Chávez, A Velarde-Ruiz Velasco, D I Flores-Ramírez, I Romero-Hernández, I Donato-Olguín, X García-Samper, A Bautista-Santos, M Reyes-Bastidas, E Millán-Marín
BACKGROUND: The predictive scale for mortality risk in patients with nonvariceal upper gastrointestinal bleeding (NVUGIB) proposed by Italy's PNED (Progetto Nazionale Emorragia Digestiva) group has not been validated in Latin America since its original publication. AIM: To compare the PNED system and the Rockall score as mortality predictors in patients hospitalized for NVUGIB. MATERIAL AND METHODS: A multicenter, prospective, cross-sectional, analytic study was conducted that recruited patients diagnosed with nonvariceal upper gastrointestinal bleeding within the time frame of 2011 to 2015...
April 2017: Revista de Gastroenterología de México
https://www.readbyqxmd.com/read/28101125/preventive-transarterial-embolization-in-upper-nonvariceal-gastrointestinal-bleeding
#6
Aleksejs Kaminskis, Aina Kratovska, Sanita Ponomarjova, Anna Tolstova, Maksims Mukans, Solvita Stabiņa, Raivis Gailums, Andrejs Bernšteins, Patricija Ivanova, Viesturs Boka, Guntars Pupelis
BACKGROUND: Transarterial embolization (TAE) is a therapeutic option for patients with a high risk of recurrent bleeding after endoscopic haemostasis. The aim of our prospective study was a preliminary assessment of the safety, efficacy, and clinical outcomes following preventive TAE in patients with non-variceal acute upper gastrointestinal bleeding (NVUGIB) with a high risk of recurrent bleeding after endoscopic haemostasis. METHODS: Preventive visceral angiography and TAE were performed after endoscopic haemostasis on patients with NVUGIB who were at a high risk of recurrent bleeding (PE+ group)...
2017: World Journal of Emergency Surgery: WJES
https://www.readbyqxmd.com/read/27928663/volume-of-hospital-is-important-for-the-prognosis-of-high-risk-patients-with-nonvariceal-upper-gastrointestinal-bleeding-nvugib
#7
Jin Woo Choi, Seong Woo Jeon, Jung Gu Kwon, Dong Wook Lee, Chang Yoon Ha, Kwang Bum Cho, Byung Ik Jang, Jung Bae Park, Youn Sun Park
BACKGROUND AND AIM: Nonvariceal upper gastrointestinal bleeding (NVUGIB) is a potentially life-threatening hospital emergency requiring hemodynamic stabilization and resuscitation. This study is carried out to determine whether hospital volume can influence outcome in patients with NVUGIB. METHOD: This is a retrospective study with a prospective cohort database (KCT 0000514. cris.nih.go.kr). Eight teaching hospitals were divided into two different groups: high-volume centers (HVC, ≥60 NVUGIB patients/year, four clinics) and low-volume centers (LVC, <60 NVUGIB patients/year, four clinics)...
August 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/27749635/using-hemospray-improves-the-cost-effectiveness-ratio-in-the-management-of-upper-gastrointestinal-nonvariceal-bleeding
#8
Alan N Barkun, Viviane Adam, Yidan Lu, Yen-I Chen, Myriam Martel
GOALS: We compared the cost-effectiveness of traditional recommended endoscopic hemostatic therapies and Hemospray alone or in combination when treating nonvariceal upper gastrointestinal bleeding (NVUGIB). BACKGROUND: Hemospray (TC-325) is a novel endoscopic hemostatic powder, achieving hemostasis through adherence to actively bleeding biological surfaces. STUDY: A decision tree of patients with NVUGIB assessed 4 possible treatment strategies: traditional therapy alone (T), Hemospray alone (H), traditional therapy completed by Hemospray if needed (T+H), or Hemospray completed by traditional therapy if needed (H+T)...
October 4, 2016: Journal of Clinical Gastroenterology
https://www.readbyqxmd.com/read/27518195/effects-of-different-omeprazole-dosing-on-gastric-ph-in-non-variceal-upper-gastrointestinal-bleeding-a-randomized-prospective-study
#9
RANDOMIZED CONTROLLED TRIAL
Adam Chwiesko, Radoslaw Charkiewicz, Jacek Niklinski, Wojciech Luczaj, Elzbieta Skrzydlewska, Robert Milewski, Andrzej Baniukiewicz, Eugeniusz Wroblewski, Mariusz Rosolowski, Andrzej Dabrowski
OBJECTIVE: We aimed to identify the best method of omeprazole (OME) application with respect to intragastric pH, cytochrome P450 2C19 (CYP2C19) genotype and phenotype. METHODS: The patients with non-variceal upper gastrointestinal bleeding (NVUGIB) were prospectively enrolled. After the achievement of endoscopic hemostasis, the patients were randomized to 40-mg intravenous (i.v.) OME bolus injection every 12 h or 8-mg/h continuous i.v. infusion for 72 h after an 80-mg i...
September 2016: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/27462392/aspirin-use-for-primary-prophylaxis-adverse-outcomes-in-non-variceal-upper-gastrointestinal-bleeding
#10
Karina M Souk, Hani M Tamim, Hussein A Abu Daya, Don C Rockey, Kassem A Barada
AIM: To compare outcomes of patients with non-variceal upper gastrointestinal bleeding (NVUGIB) taking aspirin for primary prophylaxis to those not taking it. METHODS: Patients not known to have any vascular disease (coronary artery or cerebrovascular disease) who were admitted to the American University of Beirut Medical Center between 1993 and 2010 with NVUGIB were included. The frequencies of in-hospital mortality, re-bleeding, severe bleeding, need for surgery or embolization, and of a composite outcome defined as the occurrence of any of the 4 bleeding related adverse outcomes were compared between patients receiving aspirin and those on no antithrombotics...
July 27, 2016: World Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/27377742/comparison-of-aims65-score-and-other-scoring-systems-for-predicting-clinical-outcomes-in-koreans-with-nonvariceal-upper-gastrointestinal-bleeding
#11
COMPARATIVE STUDY
Sung Min Park, Seok Cheon Yeum, Byung-Wook Kim, Joon Sung Kim, Ji Hee Kim, Eun Hui Sim, Jeong-Seon Ji, Hwang Choi
BACKGROUND/AIMS: The AIMS65 score has not been sufficiently validated in Korea. The objective of this study was to compare the AIMS65 and other scoring systems for the prediction of various clinical outcomes in Korean patients with acute nonvariceal upper gastrointestinal bleeding (NVUGIB). METHODS: The AIMS65 score, clinical and full Rockall scores (cRS and fRS) and Glasgow-Blatchford (GBS) score were calculated in patients with NVUGIB in a single center retrospectively...
July 15, 2016: Gut and Liver
https://www.readbyqxmd.com/read/27367977/simple-risk-factors-to-predict-urgent-endoscopy-in-nonvariceal-upper-gastrointestinal-bleeding-pre-endoscopically
#12
Jianzong Wang, Duanming Hu, Wen Tang, Chuanyin Hu, Qin Lu, Juan Li, Jianhong Zhu, Liming Xu, Zhenyu Sui, Mingjie Qian, Shaofeng Wang, Guojian Yin
The goal of this study is to evaluate how to predict high-risk nonvariceal upper gastrointestinal bleeding (NVUGIB) pre-endoscopically. A total of 569 NVUGIB patients between Match 2011 and January 2015 were retrospectively studied. The clinical characteristics and laboratory data were statistically analyzed. The severity of NVUGIB was based on high-risk NVUGIB (Forrest I-IIb), and low-risk NVUGIB (Forrest IIc and III). By logistic regression and receiver-operating characteristic curve, simple risk score systems were derived which predicted patients' risks of potentially needing endoscopic intervention to control bleeding...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27108061/the-use-of-hemostatic-spray-as-an-adjunct-to-conventional-hemostatic-measures-in-high-risk-nonvariceal-upper-gi-bleeding-with-video
#13
Rohit Sinha, Khalida A Lockman, Nicholas I Church, John N Plevris, Peter C Hayes
BACKGROUND: Endoscopic management of nonvariceal upper GI bleed (NVUGIB) can be challenging. Hemospray is a novel endoscopic hemostatic agent for NVUGIB. Its efficacy in attaining hemostasis in NVUGIB is promising, particularly with respect to technically difficult lesions. However, most of the currently available data are focused on its application as monotherapy. The aim of this study was to evaluate its efficacy as a second agent to adrenaline, or as an addition to the combination of adrenaline with either clips or a thermal device in NVUGIB...
December 2016: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/26921080/the-novel-scoring-system-for-30-day-mortality-in-patients-with-non-variceal-upper-gastrointestinal-bleeding
#14
MULTICENTER STUDY
Sejin Hwang, Seong Woo Jeon, Joong Goo Kwon, Dong Wook Lee, Chang Yoon Ha, Kwang Bum Cho, ByungIk Jang, Jung Bae Park, Youn Sun Park
BACKGROUND: Although the mortality rates for non-variceal upper gastrointestinal bleeding (NVUGIB) have recently decreased, it remains a significant medical problem. AIM: The main aim of this prospective multicenter database study was to construct a clinically useful predictive scoring system by using our predictors and compare its prognostic accuracy with that of the Rockall scoring system. METHODS: Data were collected from consecutive patients with NVUGIB...
July 2016: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26767858/predictive-factors-of-mortality-within-30-days-in-patients-with-nonvariceal-upper-gastrointestinal-bleeding
#15
Yoo Jin Lee, Bo Ram Min, Eun Soo Kim, Kyung Sik Park, Kwang Bum Cho, Byoung Kuk Jang, Woo Jin Chung, Jae Seok Hwang, Seong Woo Jeon
BACKGROUND/AIMS: Nonvariceal upper gastrointestinal bleeding (NVUGIB) is a common medical emergency that can be life threatening. This study evaluated predictive factors of 30-day mortality in patients with this condition. METHODS: A prospective observational study was conducted at a single hospital between April 2010 and November 2012, and 336 patients with symptoms and signs of gastrointestinal bleeding were consecutively enrolled. Clinical characteristics and endoscopic findings were reviewed to identify potential factors associated with 30-day mortality...
January 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/26289241/-comparison-on-endoscopic-hemoclip-and-hemoclip-combination-therapy-in-non-variceal-upper-gastrointestinal-bleeding-patients-based-on-clinical-practice-data-is-there-difference-between-prospective-cohort-study-and-randomized-study
#16
MULTICENTER STUDY
Su Hyun Lee, Jin Tae Jung, Dong Wook Lee, Chang Yoon Ha, Kyung Sik Park, Si Hyung Lee, Chang Heon Yang, Youn Sun Park, Seong Woo Jeon
BACKGROUND/AIMS: Endoscopic hemoclip application is an effective and safe method of endoscopic hemostasis. We conducted a multicenter retrospective study on hemoclip and hemoclip combination therapy based on prospective cohort database in terms of hemostatic efficacy not in clinical trial but in real clinical practice. METHODS: Data on endoscopic hemostasis for non-variceal upper gastrointestinal bleeding (NVUGIB) were prospectively collected from February 2011 to December 2013...
August 2015: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://www.readbyqxmd.com/read/26201415/first-line-endoscopic-treatment-with-otsc-in-patients-with-high-risk-non-variceal-upper-gastrointestinal-bleeding-preliminary-experience-in-40-cases
#17
Mauro Manno, Santi Mangiafico, Angelo Caruso, Carmelo Barbera, Helga Bertani, Vincenzo G Mirante, Flavia Pigò, Khanna Amardeep, Rita Conigliaro
BACKGROUND AND STUDY AIMS: The over-the-scope clip (OTSC; Ovesco, Tübingen, Germany) is a novel endoscopic clipping device designed for tissue approximation. The device has been used in the closure of fistulas and perforations. We hereby report a series of patients with high-risk non-variceal upper gastrointestinal bleeding (NVUGIB) lesions in whom OTSCs were used as first-line endoscopic treatment. PATIENTS AND METHODS: We prospectively collected and retrospectively analysed data over a period of 12 months from October 2013 to November 2014 from all consecutive patients who underwent emergency endoscopy for acute severe high-risk NVUGIB and were treated with OTSC as primary first-line therapy...
May 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/26177705/alcohol-abuse-increases-rebleeding-risk-and-mortality-in-patients-with-non-variceal-upper-gastrointestinal-bleeding
#18
Jussi M Kärkkäinen, Sami Miilunpohja, Tuomo Rantanen, Jenni M Koskela, Johanna Jyrkkä, Juha Hartikainen, Hannu Paajanen
BACKGROUND: No current data are available on rebleeding and mortality risk in patients who use alcohol excessively and are admitted for non-variceal upper gastrointestinal bleeding (NVUGIB). This information could help in planning interventions and follow-up protocols for these patients. AIM: This study provides contemporary data on the long-term outcome after first-time NVUGIB in alcohol abusers (AAs) compared to non-abusers (NAs). METHODS: Consecutive patients hospitalized for their first acute gastrointestinal bleeding from 2009 through 2011 were retrospectively recorded and categorized as AA or NA...
December 2015: Digestive Diseases and Sciences
https://www.readbyqxmd.com/read/26134614/embolization-versus-surgery-for-peptic-ulcer-bleeding-after-failed-endoscopic-hemostasis-a-meta-analysis
#19
REVIEW
Moe Kyaw, Yee Tse, Daphne Ang, Tiing Leong Ang, James Lau
BACKGROUND AND STUDY AIMS: A meta-analysis was conducted to assess the efficacy of transcatheter arterial embolization (TAE) compared with surgery in the management of patients with recurrent nonvariceal upper gastrointestinal bleeding (NVUGIB) after failure of endoscopic hemostasis. PATIENTS AND METHODS: Publications in English and non-English literatures (OVID, MEDLINE, and EMBASE) and abstracts from major international conferences were searched for studies comparing TAE with surgery for treatment of NVUGIB after endoscopic hemostasis failure...
March 2014: Endoscopy International Open
https://www.readbyqxmd.com/read/25732717/aspirin-has-a-protective-effect-against-adverse-outcomes-in-patients-with-nonvariceal-upper-gastrointestinal-bleeding
#20
Antonios Wehbeh, Hani M Tamim, Hussein Abu Daya, Rachel Abou Mrad, Rami J Badreddine, Mohamad A Eloubeidi, Don C Rockey, Kassem Barada
OBJECTIVE: To determine the effect of aspirin and anticoagulants on clinical outcomes and cause of in-hospital death in patients with nonvariceal upper gastrointestinal bleeding (NVUGIB). METHODS: Patients were identified from a tertiary center database that included all patients with UGIB. Clinical outcomes including (1) in-hospital mortality, (2) severe bleeding, (3) rebleeding, (4) in-hospital complications, and (5) length of hospital stay were examined in patients taking (a) aspirin only, (b) anticoagulants only, and (c) no antithrombotics...
July 2015: Digestive Diseases and Sciences
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