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https://www.readbyqxmd.com/read/27879375/the-role-of-oxidative-stress-in-koenimbine-induced-dna-damage-and-heat-shock-protein-modulation-in-hepg2-cells
#1
Yahya Hasan Hobani
Murraya koenigii (L.) Spreng, is a significant herb of traditional Ayurvedic system of medicine. Koenimbine, a carbazole alkaloid isolated from this plant holds antiproliferative and apoptotic effects. The aim of this study was to assess koenimbine-induced DNA damage and to clarify the role of free radicals in cell death mechanisms, using HepG2 cells. Methods The level of cytotoxicity was assayed by MTT assay. To elucidate the role of glutathione (GSH), the intracellular GSH level was analyzed. The effect of koenimbine in the cell mitochondria was evaluated using mitochondrial membrane potential (MMP) changes...
November 21, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/27793885/molecular-mechanisms-of-anti-metastatic-activity-of-curcumin
#2
REVIEW
Y I Deng, Elise Verron, Ramin Rohanizadeh
Cancer is the leading cause of death worldwide. Although cancer occurs as a localized disease, its morbidity and mortality rates remain high due to the ability of cancer cells to break-off from the primary tumor and spread to distant organs. Currently, chemotherapy is the main treatment for cancer; however, the increase in proportion of drug-resistant cancer cells and unpleasant side-effects of chemotherapy are still the major challenges in cancer therapy. Curcumin is a natural polyphenol compound and the main bioactive constituent of Indian spice turmeric, widely used in Indian and Chinese medicines...
November 2016: Anticancer Research
https://www.readbyqxmd.com/read/27781560/precision-medicine-in-genetic-epilepsies-break-of-dawn
#3
Philipp Sebastian Reif, Meng-Han Tsai, Ingo Helbig, Felix Rosenow, Karl Martin Klein
Therapy with current antiepileptic drugs aims at reducing the likelihood of seizure occurrence rather than influencing the underlying disease process. Therefore, antiepileptic drugs have an anticonvulsant rather than antiepileptic property. Areas covered: The increasing identification of genetic causes for epilepsy over the recent years improves the understanding of the underlying epileptogenic process and allows for the possibility of directed therapeutic approaches. An ideal antiepileptic therapy consists of a drug which is able to influence the functional changes caused by a specific pathogenic variant...
November 10, 2016: Expert Review of Neurotherapeutics
https://www.readbyqxmd.com/read/27779437/when-pain-is-medicine
#4
S Sindhu
Stripped of any sense of comfort or dignity on that hospital bed, my 84-year-old father, my best friend, was enduring raw, intrusive medical procedures against his own wish; defenseless, vulnerable, agonized. A feeding tube went in through his nose; catheter tubes drained urine out of his bladder; a suction pump drew out fluid from his airway. A needle jammed into the central line, making it impossible for him to turn his head. Dialysis took over the job of his kidneys. But no painkillers were given for fear his weak heart could not take more chemicals...
October 25, 2016: Journal of Pain & Palliative Care Pharmacotherapy
https://www.readbyqxmd.com/read/27643977/duplex-real-time-pcr-assay-using-sybr-green-to-detect-and-quantify-malayan-box-turtle-cuora-amboinensis-materials-in-meatballs-burgers-frankfurters-and-traditional-chinese-herbal-jelly-powder
#5
Asing, Md Eaqub Ali, Sharifah Bee Abd Hamid, Md Motalib Hossain, Mohammad Nasir Uddin Ahamad, S M Azad Hossain, Nina Naquiah, I S M Zaidul
The Malayan box turtle (Cuora amboinensis) (MBT) is a vulnerable and protected species widely used in exotic foods and traditional medicines. Currently available polymerase chain reaction (PCR) assays to identify MBT lack automation and involve long targets which break down in processed or denatured tissue. This SYBR Green duplex real-time PCR assay has addressed this research gap for the first time through the combination of 120- and 141-bp targets from MBT and eukaryotes for the quantitative detection of MBT DNA in food chain and herbal medicinal preparations...
October 17, 2016: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/27642271/metabolomics-enables-precision-medicine-a-white-paper-community-perspective
#6
Richard D Beger, Warwick Dunn, Michael A Schmidt, Steven S Gross, Jennifer A Kirwan, Marta Cascante, Lorraine Brennan, David S Wishart, Matej Oresic, Thomas Hankemeier, David I Broadhurst, Andrew N Lane, Karsten Suhre, Gabi Kastenmüller, Susan J Sumner, Ines Thiele, Oliver Fiehn, Rima Kaddurah-Daouk
INTRODUCTION BACKGROUND TO METABOLOMICS: Metabolomics is the comprehensive study of the metabolome, the repertoire of biochemicals (or small molecules) present in cells, tissues, and body fluids. The study of metabolism at the global or "-omics" level is a rapidly growing field that has the potential to have a profound impact upon medical practice. At the center of metabolomics, is the concept that a person's metabolic state provides a close representation of that individual's overall health status...
2016: Metabolomics: Official Journal of the Metabolomic Society
https://www.readbyqxmd.com/read/27536285/veterinary-medicine-needs-new-green-antimicrobial-drugs
#7
REVIEW
Pierre-Louis Toutain, Aude A Ferran, Alain Bousquet-Melou, Ludovic Pelligand, Peter Lees
Given that: (1) the worldwide consumption of antimicrobial drugs (AMDs) used in food-producing animals will increase over the coming decades; (2) the prudent use of AMDs will not suffice to stem the rise in human antimicrobial resistance (AMR) of animal origin; (3) alternatives to AMD use are not available or not implementable, there is an urgent need to develop novel AMDs for food-producing animals. This is not for animal health reasons, but to break the link between human and animal resistomes. In this review we establish the feasibility of developing for veterinary medicine new AMDs, termed "green antibiotics," having minimal ecological impact on the animal commensal and environmental microbiomes...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27525019/chinese-herbal-mixture-tien-hsien-liquid-induces-g2-m-cycle-arrest-and-radiosensitivity-in-mcf-7-human-breast-cancer-cells-through-mechanisms-involving-dnmt1-and-rad51-downregulation
#8
Chih-Jung Yao, Jyh-Ming Chow, Chia-Ming Yang, Hui-Ching Kuo, Chia-Lun Chang, Hsin-Lun Lee, I-Chun Lai, Shuang-En Chuang, Gi-Ming Lai
The Chinese herbal mixture, Tien-Hsien Liquid (THL), has been proven to suppress the growth and invasiveness of cancer cells and is currently regarded as a complementary medicine for the treatment of cancer. Our previous study using acute promyelocytic leukemia cells uncovered its effect on the downregulation of DNA methyltransferase 1 (DNMT1) which is often overexpressed in cancer cells resulting in the repression of tumor suppressors via hypermethylation. Herein, we explored the effects of THL in MCF-7 breast cancer cells that also demonstrate elevated DNMT1...
2016: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/27497456/innovative-patient-centered-skills-training-addressing-challenging-issues-in-cancer-communications-using-patient-s-stories-that-teach
#9
Thomas W Bishop, James Gorniewicz, Michael Floyd, Fred Tudiver, Amy Odom, Kathy Zoppi
This workshop demonstrated the utility of a patient-centered web-based/digital Breaking Bad News communication training module designed to educate learners of various levels and disciplines. This training module is designed for independent, self-directed learning as well as group instruction. These interactive educational interventions are based upon video-recorded patient stories. Curriculum development was the result of an interdisciplinary, collaborative effort involving faculty from the East Tennessee State University (ETSU) Graduate Storytelling Program and the departments of Family and Internal Medicine at the James H...
May 2016: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/27404275/the-effect-of-information-on-preferences-for-treatments-of-metastatic-renal-cell-carcinoma
#10
Carol Mansfield, Sandy Srinivas, Connie Chen, A Brett Hauber, Subramanian Hariharan, Ewa Matczak, Rickard Sandin
OBJECTIVE: Limited information exists regarding the effect of uncertainty in outcomes on patient preferences for metastatic renal cell carcinoma (mRCC) treatments. This study tested the effect on patients' preferences and willingness to tolerate toxicities when patients were provided information about possible correlations between treatment-related toxicities and efficacy. RESEARCH DESIGN AND METHODS: Patients with self-reported RCC diagnosis completed an online survey...
July 12, 2016: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/27368114/dna-damage-repair-and-the-emerging-role-of-poly-adp-ribose-polymerase-inhibition-in-cancer-therapeutics
#11
REVIEW
Karen Rabenau, Erin Hofstatter
PURPOSE: As a result of improved understanding of DNA repair mechanisms, poly(ADP-ribose) polymerase inhibitors (PARPi) are increasingly recognized to play an important therapeutic role in the treatment of cancer. The aim of this article is to provide a review of PARPi function in DNA damage repair and synthetic lethality and to demonstrate how these mechanisms can be exploited to provide new PARPi-based therapies to patients with solid tumors. METHODS: Literature from a range of sources, including PubMed and MEDLINE, were searched to identify recent reports regarding DNA damage repair and PARPi...
July 2016: Clinical Therapeutics
https://www.readbyqxmd.com/read/27345434/crispr-cas9-technology-applications-and-human-disease-modelling
#12
Raul Torres-Ruiz, Sandra Rodriguez-Perales
Genome engineering is a powerful tool for a wide range of applications in biomedical research and medicine. The development of the clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 system has revolutionized the field of gene editing, thus facilitating efficient genome editing through the creation of targeted double-strand breaks of almost any organism and cell type. In addition, CRISPR-Cas9 technology has been used successfully for many other purposes, including regulation of endogenous gene expression, epigenome editing, live-cell labelling of chromosomal loci, edition of single-stranded RNA and high-throughput gene screening...
June 26, 2016: Briefings in Functional Genomics
https://www.readbyqxmd.com/read/27282999/a-philosophical-argument-against-evidence-based-policy
#13
Rani Lill Anjum, Stephen D Mumford
RATIONALE, AIMS AND OBJECTIVES: Evidence-based medicine has two components. The methodological or ontological component consists of randomized controlled trials and their systematic review. This makes use of a difference-making conception of cause. But there is also a policy component that makes a recommendation for uniform intervention, based on the evidence from randomized controlled trials. METHODS: The policy side of evidence-based medicine is basically a form of rule utilitarianism...
June 10, 2016: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/27273989/-application-of-silk-based-tissue-engineering-scaffold-for-tendon-ligament-regeneration
#14
Yejun Hu, Huihui Le, Zhangchu Jin, Xiao Chen, Zi Yin, Weiliang Shen, Hongwei Ouyang
Tendon/ligament injury is one of the most common impairments in sports medicine. The traditional treatments of damaged tissue repair are unsatisfactory, especially for athletes, due to lack of donor and immune rejection. The strategy of tissue engineering may break through these limitations, and bring new hopes to tendon/ligament repair, even regeneration. Silk is a kind of natural biomaterials, which has good biocompatibility, wide range of mechanical properties and tunable physical structures; so it could be applied as tendon/ligament tissue engineering scaffolds...
March 2016: Zhejiang da Xue Xue Bao. Yi Xue Ban, Journal of Zhejiang University. Medical Sciences
https://www.readbyqxmd.com/read/27245022/-advantages-of-population-pharmacokinetics-and-its-application-in-the-field-of-traditional-chinese-medicine
#15
Jun-jie Jiang, Jian-nong Wang, Yan-ming Xie
The accurate medical treatment is based on the information of the genome, which is the best treatment for the patients. Population pharmacokinetic study can be formulated according to the individual differences of patients to the dose, in the accurate medical model which has a unique advantage. At present, there are many problems such as adverse drug reaction in Chinese traditional medicine, and it is necessary to introduce a group of medicine on the basis of precise medical treatment. However, due to the different characteristics of traditional Chinese medicine and chemical medicine, it is necessary to combine the population pharmacokinetics, genetics and statistical methods to establish a research method which is in line with the characteristics of Chinese medicine...
December 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/27177238/berberine-in-combination-with-cisplatin-suppresses-breast-cancer-cell-growth-through-induction-of-dna-breaks-and-caspase-3-dependent-apoptosis
#16
Yuwan Zhao, Zuolei Jing, Yan Li, Weifeng Mao
Berberine (BBR) is an isoquinoline alkaloid extracted from medicinal plants such as Hydrastis canadensis, Berberis aristata and Coptis chinensis. BBR displays a number of beneficial roles in the treatment of various types of cancers, yet the precise mechanisms of its action remain unclear. Cisplatin is an effective cancer chemotherapeutic agent and functions by generating DNA damage, promoting DNA damage-induced cell cycle arrest and apoptosis; however, its efficacy is challenged by the resistance of tumor cells in clinical application...
July 2016: Oncology Reports
https://www.readbyqxmd.com/read/27176745/cost-evaluation-of-clinical-laboratory-in-taiwan-s-national-health-system-by-using-activity-based-costing
#17
Bin-Guang Su, Shao-Fen Chen, Shu-Hsing Yeh, Po-Wen Shih, Ching-Chiang Lin
BACKGROUND: To cope with the government's policies to reduce medical costs, Taiwan's healthcare service providers are striving to survive by pursuing profit maximization through cost control. This article aimed to present the results of cost evaluation using activity-based costing performed in the laboratory in order to throw light on the differences between costs and the payment system of National Health Insurance (NHI). METHODS: This study analyzed the data of costs and income of the clinical laboratory...
May 13, 2016: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/27136089/designing-highly-structured-polycaprolactone-fibers-using-microfluidics
#18
Farrokh Sharifi, Diamant Kurteshi, Nastaran Hashemi
Microfibers are becoming increasingly important for biomedical applications such as regenerative medicine and tissue engineering. We have used a microfluidic approach to create polycaprolactone (PCL) microfibers in a controlled manner. Through the variations of the sheath fluid flow rate and PCL concentration in the core solution, the morphology of the microfibers and their cross-sections can be tuned. The microfibers were made using PCL concentrations of 2%, 5%, and 8% in the core fluid with a wide range of sheath-to-core flow rate ratios from 120:5µL/min to 10:5µL/min, respectively...
August 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/27071242/-present-situation-and-development-strategies-of-chinese-medicine-preparation-in-medical-institutions
#19
Jie Wang, Xi-Yao Qiao, Fei Lin
As the actual clinical reflecting of transform Chinese medicine special curative effect, Chinese medicine preparation not only satisfies the need of hospital clinic, scientific research and teaching, but also plays an important role in deepening medical and health system reform, improving people's health level and contributing to the economic growth. However, some problems about administration and approval (tending to western medicine), contraction of the scale, lack of synchronization for clinic and scientific research, and the imbalance of regional development make Chinese medicine preparation move forwards slowly in contradiction...
November 2015: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/26819439/-the-korean-pharmaceutical-industry-and-the-expansion-of-the-general-pharmaceuticals-market-in-the-1950-1960s
#20
Kyu-Hwan Sihn
After the Liberation, the Korean economy was dependent on relief supplies and aid after the ruin of the colonial regime and war. The pharmaceutical business also searched for their share in the delivery of military supplies and the distribution of relief supplies. The supply-side pharmaceutical policy made the pharmaceutical market a wholesale business. The gravity of the situation led to an increased importation of medical supplies, and wholesalers took the lead in establishing the distribution structure, whereas consumers and pharmaceutical business were relatively intimidated...
December 2015: Ŭi Sahak
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