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https://www.readbyqxmd.com/read/28433796/genetic-diversity-and-virulence-genes-of-salmonella-enterica-subspecies-enterica-serotype-enteritidis-isolated-from-meats-and-eggs
#1
Fatemeh Fardsanei, Mohammad Mehdi Soltan Dallal, Masoumeh Douraghi, Taghi Zahraei Salehi, Mahmood Mahmoodi, Hamed Memariani, Farhad Nikkhahi
Salmonella enterica subspecies enterica serotype Enteritidis (S. Enteritidis) is one of the leading causes of food-borne gastroenteritis associated with the consumption of contaminated food products of animal origin. Little is known about the genetic diversity and virulence content of S. Enteritidis isolated from poultry meats and eggs in Iran. A total of 34 S. Enteritidis strains were collected from different food sources of animal origin in Tehran from May 2015 to July 2016. All of the S. Enteritidis strains were serotyped, antimicrobial susceptibility tested, and characterized for virulence genes...
April 19, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28433558/spatial-relationship-of-organized-rotational-and-focal-sources-in-human-atrial-fibrillation-to-autonomic-ganglionated-plexi
#2
Tina Baykaner, Theodoros A Zografos, Junaid A B Zaman, Ioannis Pantos, Mahmood Alhusseini, Rachita Navara, David E Krummen, Sanjiv M Narayan, Demosthenes G Katritsis
BACKGROUND: One approach to improve ablation for atrial fibrillation (AF) is to focus on physiological targets including focal or rotational sources or ganglionic plexi (GP). However, the spatial relationship between these potential mechanisms has never been studied. We tested the hypothesis that rotors and focal sources for AF may co-localize with ganglionated plexi (GP). METHODS: We prospectively identified locations of AF rotors and focal sources, and correlated these to GP sites in 97 consecutive patients (age 59...
April 19, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28433160/thiolated-chitosan-micelles-highly-mucoadhesive-drug-carriers
#3
Arshad Mahmood, Melanie Lanthaler, Flavia Laffleur, Christian W Huck, Andreas Bernkop-Schnürch
Current study was aimed to generate thiolated chitosan micelles based on amphiphilic chitosan-stearic acid conjugate (CSA) and to evaluate adhesive properties on mucosal membranes. Chitosan-stearic acid-thioglycolic acid (CSA-TGA) conjugate was synthesized via stearic acid linkage to chitosan and later, thioglycolic acid was covalently attached to CSA. CSA-TGA and CSA were characterized by degree of amine substitution, thiol group determination, ATR-FTIR and cytotoxicity analysis. Micelle size was 13.40±9...
July 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28431549/household-food-insecurity-is-associated-with-abdominal-but-not-general-obesity-among-iranian-children
#4
Fateme Jafari, Simin Ehsani, Azadeh Nadjarzadeh, Ahmad Esmaillzadeh, Mahmood Noori-Shadkam, Amin Salehi-Abargouei
BACKGROUND: Childhood obesity is increasing all over the world. Food insecurity is mentioned as a possible risk factor; however, previous studies have led to inconsistent results in different societies while data are lacking for the Middle East. We aimed to investigate the relationship between food insecurity and general or abdominal obesity in Iranian children in a cross-sectional study. METHODS: Anthropometric data including height, weight, and waist circumference were measured by trained nutritionists...
April 21, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28427897/boosters-and-barriers-for-direct-cardiac-reprogramming
#5
REVIEW
Mahmood Talkhabi, Elmira Rezaei Zonooz, Hossein Baharvand
Heart disease is currently the most significant cause of morbidity and mortality worldwide, which accounts for approximately 33% of all deaths. Recently, a promising and alchemy-like strategy has been developed called direct cardiac reprogramming, which directly converts somatic cells such as fibroblasts to cardiac lineage cells such as cardiomyocytes (CMs), termed induced CMs or iCMs. The first in vitro cardiac reprogramming study, mediated by cardiac transcription factors (TFs)-Gata4, Tbx5 and Mef2C-, was not enough efficient to produce an adequate number of fully reprogrammed, functional iCMs...
April 17, 2017: Life Sciences
https://www.readbyqxmd.com/read/28422778/ultrasound-as-a-screening-tool-for-central-venous-catheter-positioning-and-exclusion-of-pneumothorax
#6
Rabia Amir, Ziyad O Knio, Feroze Mahmood, Achikam Oren-Grinberg, Akiva Leibowitz, Ruma Bose, Shahzad Shaefi, John D Mitchell, Muneeb Ahmed, Amit Bardia, Daniel Talmor, Robina Matyal
OBJECTIVES: Although real-time ultrasound guidance during central venous catheter insertion has become a standard of care, postinsertion chest radiograph remains the gold standard to confirm central venous catheter tip position and rule out associated lung complications like pneumothorax. We hypothesize that a combination of transthoracic echocardiography and lung ultrasound is noninferior to chest radiograph when used to accurately assess central venous catheter positioning and screen for pneumothorax...
April 18, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28422704/influencing-factors-on-high-risk-sexual-behaviors-in-young-people-an-ecological-perspective
#7
Hoda Arabi-Mianrood, Zeinab Hamzehgardeshi, Elham Khoori, Mahmood Moosazadeh, Zohreh Shahhosseini
Background In recent years, high-risk sexual behaviors due to their negative consequences both for the individual and society have received more attention than other high-risk behaviors. Objective The aim of this study was to review the influencing factors of high-risk sexual behaviors among young people from an ecological point of view. Methods This review was conducted through searching databases including PubMed, Web of Science, Scopus, Google Scholar and the Cochrane Library with keywords such as sexual risk-taking behavior, high-risk sex, unprotected sex and unsafe sex...
April 19, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28417046/re-coexistence-of-autism-spectrum-disorders-among-three-children-with-tuberous-sclerosis-complex-case-reports-and-review-of-literature
#8
COMMENT
Mahmood D Al-Mendalawi
No abstract text is available yet for this article.
February 2017: Sultan Qaboos University Medical Journal
https://www.readbyqxmd.com/read/28413440/predictors-of-depression-among-patients-receiving-treatment-for-snakebite-in-general-hospital-kaltungo-gombe-state-nigeria-august-2015
#9
Abdulaziz Muhammed, Mahmood M Dalhat, Babalola O Joseph, Abubakar Ahmed, Patrick Nguku, Gabriele Poggensee, Mukthar Adeiza, Garba I Yahya, Muhammad Hamza, Zaiyad G Habib, Abisola M Oladimeji, Abdulsalam Nasidi, Abubakar Balla, Ibrahim Nashabaru, Nasir Sani-Gwarzo, Ahmad M Yakasai, Joshua A Difa, Taiwo Lateef Sheikh, Abdulrazaq G Habib
BACKGROUND: Snakebite though neglected, affects 5 million people yearly. More neglected is the psychological effect of envenomation. We determined prevalence and pattern of depression among patients admitted into snakebite wards of Kaltungo General Hospital Nigeria, and percentage recognized by clinicians. We also assessed for factors associated with depression. METHODS: In a descriptive hospital based study, we used Patient Health questionnaire (PHQ-9) to make diagnosis of depression among the patients...
2017: International Journal of Mental Health Systems
https://www.readbyqxmd.com/read/28408970/differential-regulation-of-cardiac-function-and-intracardiac-cytokines-by-rapamycin-in-healthy-and-diabetic-rats
#10
Christian Luck, Vincent G DeMarco, Abuzar Mahmood, Madhavi P Gavini, Lakshmi Pulakat
Diabetes is comorbid with cardiovascular disease and impaired immunity. Rapamycin improves cardiac functions and extends lifespan by inhibiting the mechanistic target of rapamycin complex 1 (mTORC1). However, in diabetic murine models, Rapamycin elevates hyperglycemia and reduces longevity. Since Rapamycin is an immunosuppressant, we examined whether Rapamycin (750 μg/kg/day) modulates intracardiac cytokines, which affect the cardiac immune response, and cardiac function in male lean (ZL) and diabetic obese Zucker (ZO) rats...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28408799/the-antiulcer-effect-of-cibotium-barometz-leaves-in-rats-with-experimentally-induced-acute-gastric-ulcer
#11
Nahla Saeed Al-Wajeeh, Maryam Hajrezaie, Nawal Al-Henhena, Sareh Kamran, Elham Bagheri, Maryam Zahedifard, Kamelia Saremi, Suzita Mohd Noor, Hapipah Mohd Ali, Mahmood Ameen Abdulla
Cibotium barometz is a pharmaceutical plant customarily used in traditional medicine in Malaysia for the treatment of different diseases, such as gastric ulcer. The gastroprotective effect of C. barometz leaves against ethanol-induced gastric hemorrhagic abrasions in Sprague Dawley rats has been evaluated in terms of medicinal properties. Seven groups of rats (normal control and ulcerated control groups, omeprazole 20 mg/kg, 62.5, 125, 250, and 500 mg/kg of C. barometz correspondingly) were used in antiulcer experiment and pretreated with 10% Tween 20...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28408323/apolipoprotein-a-isoform-size-lipoprotein-a-concentration-and-coronary-artery-disease-a-mendelian-randomisation-analysis
#12
Danish Saleheen, Philip C Haycock, Wei Zhao, Asif Rasheed, Adam Taleb, Atif Imran, Shahid Abbas, Faisal Majeed, Saba Akhtar, Nadeem Qamar, Khan Shah Zaman, Zia Yaqoob, Tahir Saghir, Syed Nadeem Hasan Rizvi, Anis Memon, Nadeem Hayyat Mallick, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Khalid Mahmood, Naveeduddin Ahmed, Philippe Frossard, Sotirios Tsimikas, Joseph L Witztum, Santica Marcovina, Manjinder Sandhu, Daniel J Rader, John Danesh
BACKGROUND: The lipoprotein(a) pathway is a causal factor in coronary heart disease. We used a genetic approach to distinguish the relevance of two distinct components of this pathway, apolipoprotein(a) isoform size and circulating lipoprotein(a) concentration, to coronary heart disease. METHODS: In this mendelian randomisation study, we measured lipoprotein(a) concentration and determined apolipoprotein(a) isoform size with a genetic method (kringle IV type 2 [KIV2] repeats in the LPA gene) and a serum-based electrophoretic assay in patients and controls (frequency matched for age and sex) from the Pakistan Risk of Myocardial Infarction Study (PROMIS)...
April 10, 2017: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/28408165/alterations-in-protein-phosphorylation-in-the-amygdala-of-the-5xfamilial-alzheimer-s-disease-animal-model
#13
Eun-Jeong Yang, Usman Mahmood, Hyunju Kim, Moonseok Choi, Yunjung Choi, Jean-Pyo Lee, Moon-Jeong Chang, Hye-Sun Kim
Alzheimer's disease is the most common disease underlying dementia in humans. Two major neuropathological hallmarks of AD are neuritic plaques primarily composed of amyloid beta peptide and neurofibrillary tangles primarily composed of hyperphosphorylated tau. In addition to impaired memory function, AD patients often display neuropsychiatric symptoms and abnormal emotional states such as confusion, delusion, manic/depressive episodes and altered fear status. Brains from AD patients show atrophy of the amygdala which is involved in fear expression and emotional processing as well as hippocampal atrophy...
March 31, 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28406212/human-knockouts-and-phenotypic-analysis-in-a-cohort-with-a-high-rate-of-consanguinity
#14
Danish Saleheen, Pradeep Natarajan, Irina M Armean, Wei Zhao, Asif Rasheed, Sumeet A Khetarpal, Hong-Hee Won, Konrad J Karczewski, Anne H O'Donnell-Luria, Kaitlin E Samocha, Benjamin Weisburd, Namrata Gupta, Mozzam Zaidi, Maria Samuel, Atif Imran, Shahid Abbas, Faisal Majeed, Madiha Ishaq, Saba Akhtar, Kevin Trindade, Megan Mucksavage, Nadeem Qamar, Khan Shah Zaman, Zia Yaqoob, Tahir Saghir, Syed Nadeem Hasan Rizvi, Anis Memon, Nadeem Hayyat Mallick, Mohammad Ishaq, Syed Zahed Rasheed, Fazal-Ur-Rehman Memon, Khalid Mahmood, Naveeduddin Ahmed, Ron Do, Ronald M Krauss, Daniel G MacArthur, Stacey Gabriel, Eric S Lander, Mark J Daly, Philippe Frossard, John Danesh, Daniel J Rader, Sekar Kathiresan
A major goal of biomedicine is to understand the function of every gene in the human genome. Loss-of-function mutations can disrupt both copies of a given gene in humans and phenotypic analysis of such 'human knockouts' can provide insight into gene function. Consanguineous unions are more likely to result in offspring carrying homozygous loss-of-function mutations. In Pakistan, consanguinity rates are notably high. Here we sequence the protein-coding regions of 10,503 adult participants in the Pakistan Risk of Myocardial Infarction Study (PROMIS), designed to understand the determinants of cardiometabolic diseases in individuals from South Asia...
April 12, 2017: Nature
https://www.readbyqxmd.com/read/28405936/population-pharmacokinetics-some-observations-in-pediatric-modeling-for-drug-clearance
#15
Iftekhar Mahmood, Million A Tegenge
The objective of this study is to evaluate the predictive performance of several models to predict drug clearance in preterm and term neonates. Five models using different types of allometric and linear models were developed. Two sets of data were used to develop these models (data from preterm neonates to adults and data from preterm and term neonates). Models were also developed with (normalized to 70 kg) or without body weight normalization (body weight 1 kg). From the literature, clearance values for four drugs from neonates to adults were obtained...
April 12, 2017: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/28405171/estimation-of-the-depth-of-the-thoracic-epidural-space-in-children-using-magnetic-resonance-imaging
#16
Tariq M Wani, Mahmood Rafiq, Arif Nazir, Hatem A Azzam, Usama Al Zuraigi, Joseph D Tobias
BACKGROUND: The estimation of the distance from the skin to the thoracic epidural space or skin to epidural depth (SED) may increase the success rate and decrease the incidence of complications during placement of a thoracic epidural catheter. Magnetic resonance imaging (MRI) is the most comprehensive imaging modality of the spine, allowing for the accurate determination of tissue spaces and distances. The present study uses MRI-derived measurements to measure the SED and define the ratio between the straight and inclined SEDs at two thoracic levels (T6-7 and T9-10) in children...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28404638/kidney-triglyceride-accumulation-in-the-fasted-mouse-is-dependent-upon-serum-free-fatty-acids
#17
Diego Scerbo, Ni-Huiping Son, Alaa Sirwi, Lixia Zeng, Kelli M Sas, Vincenza Cifarelli, Gabriele Schoiswohl, Lesley-Ann Huggins, Namrata Gumaste, Yunying Hu, Subramaniam Pennathur, Nada A Abumrad, Erin E Kershaw, M Mahmood Hussain, Katalin Susztak, Ira J Goldberg
Lipid accumulation is a pathological feature of every type of kidney injury. Despite this striking histological feature, physiological accumulation of lipids in the kidney is poorly understood. We studied whether the accumulation of lipids in the fasted kidney are derived from lipoproteins or non-esterified fatty acids (NEFAs). With overnight fasting, kidneys accumulated triglyceride but had reduced levels of ceramide and glycosphingolipid species. Fasting led to a nearly 5-fold increase in kidney uptake of plasma [14C]oleic acid...
April 12, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28401147/toxinotyping-and-sequencing-of-clostridium-difficile-isolates-from-patients-in-a-tertiary-care-hospital-of-northern-india
#18
Meenakshi Singh, Chetana Vaishnavi, Safrun Mahmood, Rakesh Kochhar
BACKGROUND: Clostridium difficile is an important cause of infectious colitis among hospitalized patients across the globe. The pathogenic potential of C. difficile in producing significant morbidity and mortality is mainly due to production of toxins A and B. The outbreaks of C. difficile infection (CDI) are due to changes in the genetic sequences of the organism. There is hardly any molecular study reported on the prevalent types of C. difficile strains in India. Toxinotyping and sequencing of locally circulating C...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28400393/health-research-priorities-and-gaps-in-south-asia
#19
Soumya Swaminathan, Huma Qureshi, Mahmood Uz Jahan, Dharma K Baskota, Sunil De Alwis, Lalit Dandona
No abstract text is available yet for this article.
April 11, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28399454/detection-of-a-synthetic-sex-steroid-in-the-american-crocodile-crocodylus-acutus-evidence-for-a-novel-environmental-androgen
#20
Christopher M Murray, Mark Merchant, Michael Easter, Sergio Padilla, Davinia B Garrigós, Mahmood Sasa Marin, Craig Guyer
Endocrine-disrupting contaminants (EDC's) are well known to alter sexual differentiation among vertebrates via estrogenic effects during development, particularly in organisms characterized by temperature-dependent sex determination. However, substances producing androgenic effects typically lack potency when tested in laboratory settings and are virtually unstudied in field settings. Here, we assay levels of a synthetic androgen, 17α-methyltestosterone (MT), in a heavily male-biased population of American crocodiles in the Tempisque River Basin of Costa Rica based on the recent hypothesis that this chemical is an EDC in developing crocodilian embryos...
April 5, 2017: Chemosphere
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