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https://www.readbyqxmd.com/read/29775982/the-supraclavicular-artery-perforator-flap-a-comparative-study-of-imaging-techniques-used-in-preoperative-mapping
#1
Hemin Oathman Sheriff, Kawa Abdullah Mahmood, Nzar Hamawandi, Aram Jamal Mirza, Jawad Hawas, Esther Granell Moreno, Juan Antonio Clavero, Christopher Hankins, Jaume Masia
BACKGROUND:  The supraclavicular artery flap is an excellent flap for head and neck reconstruction. The aim of this study is to assess imaging techniques to define the precise vascular boundaries of this flap. METHODS:  Six imaging techniques were used for supraclavicular artery mapping in 65 cases; handheld Doppler, triplex ultrasound, computed tomography angiography, magnetic resonance angiography, digital subtraction angiography, and indocyanine green angiography...
May 18, 2018: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/29773013/critical-review-on-curcumin-as-a-therapeutic-agent-from-traditional-herbal-medicine-to-an-ideal-therapeutic-agent
#2
Muhammad Usman Akbar, Kanwal Rehman, Khalid Mahmood Zia, Muhammad Imran Qadir, Muhammad Sajid Hamid Akash, Muhammad Ibrahim
Traditionally, many natural medicinal plants have been used to treat a variety of diseases since ancient times and are considered a potential source of phytochemicals for the development of new drugs. One of these is curcumin, which is an easily accessible, inexpensive, and nontoxic bioactive compound. Curcumin is a very important, naturally occurring, and highly lipophilic and phenolic substance derived from the rhizomes of plant Curcuma longa, a member of the Zingiberaceae (ginger) family, which is mostly used as a curry spice, flavoring agent, insect repellent, coloring agent in food, traditional drug, and ingredient in cosmetics...
2018: Critical Reviews in Eukaryotic Gene Expression
https://www.readbyqxmd.com/read/29772871/access-to-dialysis-services-a-systematic-mapping-review-based-on-geographical-information-systems
#3
Benyamin Hoseini, Nasser Bagheri, Behzad Kiani, Amirabbas Azizi, Hamed Tabesh, Mahmood Tara
Equitable access to healthcare services constitutes one of the leading priorities of healthcare provision and access to dialysis services (ADS) has an essential impact on patients depending on renal dialysis. The many existing GIS-based ADS evaluations include various spatial and non-spatial factors affecting ADS. We systematically mapped and reviewed the available literature with reference to this area identifying gaps in current GIS-based ADS measurements and developing recommendations for future studies...
May 7, 2018: Geospatial Health
https://www.readbyqxmd.com/read/29772469/synthesis-of-steroidal-imidazolidinthiones-as-potential-apoptotic-agents-investigation-by-theoretical-and-experimental-studies
#4
Ayaz Mahmood Dar, Rizwan Nabi, Shafia Mir, Manzoor Ahmad Gatoo, Shamsuzzaman, Shabir H Lone
New steroidal imidazolidinthione derivatives (4-6) were synthesized from steroidal thiosemicarbazones and dichloroethane. The synthesized compounds were characterized using spectral data analysis. Theoretical DFT involving B3LYP/6-31G∗∗ level of theory was employed to gain insights into the molecular structure of the target compounds. MEPS and FMO analysis were carried out. HOMO-LUMO energy gap was determined which helped to evaluate various global descriptors like hardness, chemical potential, electronegativity, nucleophilicity and electrophilicity index, etc...
May 2, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29771107/design-and-synthesis-of-a-biocompatible-1d-coordination-polymer-as-anti-breast-cancer-drug-carrier-5-fu-in-vitro-and-in-vivo-studies
#5
Mahsa Rezaei, Alireza Abbasi, Rassoul Dinarvand, Mahmood Jeddi-Tehrani, Jan Janczak
Designable coordination polymers with suitable chemical diversities and biocompatible structures have been proposed as a promising class of vehicles for drug delivery systems. Here, we hydrothermally synthesized a novel one-dimensional (1D) coordination polymer, [Zn(H2 O)6 K2 (H2 BTC)2 (H2 O)4 ](H2 BTC)2 ·2H2 O, where H3 BTC = benzene-1,3,5-tricarboxylic acid (trimesic acid), cp.1. As the hydrogen bonds stabilized 1D chains in three dimensions, the cp.1 could be a good candidate for delivering small-molecule chemotherapeutics such as 5-fluorouracil (5-Fu)...
May 17, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29769445/vegf-vegfr2-blockade-does-not-cause-retinal-atrophy-in-amd-relevant-models
#6
Da Long, Yogita Kanan, Jikui Shen, Sean F Hackett, Yuanyuan Liu, Zibran Hafiz, Mahmood Khan, Lili Lu, Peter A Campochiaro
Intraocular injections of VEGF-neutralizing proteins provide tremendous benefits in patients with choroidal neovascularization (NV) due to age-related macular degeneration (AMD), but during treatment some patients develop retinal atrophy. Suggesting that VEGF is a survival factor for retinal neurons, a clinical trial group attributed retinal atrophy to VEGF suppression and cautioned against frequent anti-VEGF injections. This recommendation may contribute to poor outcomes in clinical practice from insufficient treatment...
May 17, 2018: JCI Insight
https://www.readbyqxmd.com/read/29765576/a-trend-analysis-of-surgical-operations-under-a-global-payment-system-in-tehran-iran-2005-2015
#7
Faranak Behzadi Goudari, Arash Rashidian, Mohammad Arab, Mahmood Mahmoudi, Ebrahim Jaafaripooyan
Background: Global payment system is a first example of per-case payment system that contains 60 commonly used surgical operations for which payment is based on the average cost per case in Iran. Objective: The aim of the study was to determine the amount of reduction, increase or no change in the trend of global operations. Methods: In this retrospective longitudinal study, data on the 60 primary global surgery codes was gathered from Tehran Health Insurance Organization within the ten-year period of 2005-2015 separately, for each month...
March 2018: Electronic Physician
https://www.readbyqxmd.com/read/29764704/current-understanding-of-neuroinflammation-after-traumatic-brain-injury-and-cell-based-therapeutic-opportunities
#8
REVIEW
Ye Xiong, Asim Mahmood, Michael Chopp
Traumatic brain injury (TBI) remains a major cause of death and disability worldwide. Increasing evidence indicates that TBI is an important risk factor for neurodegenerative diseases including Alzheimer's disease, Parkinson's disease, and chronic traumatic encephalopathy. Despite improved supportive and rehabilitative care of TBI patients, unfortunately, all late phase clinical trials in TBI have yet to yield a safe and effective neuroprotective treatment. The disappointing clinical trials may be attributed to variability in treatment approaches and heterogeneity of the population of TBI patients as well as a race against time to prevent or reduce inexorable cell death...
April 24, 2018: Chinese Journal of Traumatology, Zhonghua Chuang Shang za Zhi
https://www.readbyqxmd.com/read/29764219/morningness-eveningness-preferences-learning-approach-and-academic-achievement-of-undergraduate-medical-students
#9
Nimra Akram, Naheed Khan, Mehreen Ameen, Shahmeera Mahmood, Komal Shamim, Marium Amin, Qurrat Ul Ain Rana
Several studies have focused on determining the effect of chronotype and learning approach on academic achievement separately indicating that morning types have an academic advantage over the evening types and so have the deep learners over the surface learners. But, surprisingly none have assessed the possible relationship between chronotype and learning approach. So, the current study aimed to evaluate this association and their individual influence on academic performance as indicated by the Cumulative Grade Point Average (CGPA) as well as the effect of their interaction on academic performance...
May 15, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29762500/circulating-micrornas-in-young-patients-with-acute-coronary-syndrome
#10
Kind-Leng Tong, Ahmad Syadi Mahmood Zuhdi, Wan Azman Wan Ahmad, Paul M Vanhoutte, Joao Pedro de Magalhaes, Mohd Rais Mustafa, Pooi-Fong Wong
Circulating microRNAs (miRNAs) hold great potential as novel diagnostic markers for acute coronary syndrome (ACS). This study sought to identify plasma miRNAs that are differentially expressed in young ACS patients (mean age of 38.5 ± 4.3 years) and evaluate their diagnostic potentials. Small RNA sequencing (sRNA-seq) was used to profile plasma miRNAs. Discriminatory power of the miRNAs was determined using receiver operating characteristic (ROC) analysis. Thirteen up-regulated and 16 down-regulated miRNAs were identified in young ACS patients...
May 15, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29760788/the-effectiveness-of-stress-management-training-on-blood-glucose-control-in-patients-with-type-2-diabetes
#11
Fereshteh Zamani-Alavijeh, Marzieh Araban, Hamid Reza Koohestani, Mahmood Karimy
Background: Type 2 diabetes is a chronic disease that is expanding at an alarming rate in the world. Research on individuals with type 2 diabetes showed that stressful life events cause problems in the effective management and control of diabetes. This study aimed at investigating the effect of a stress management intervention on blood glucose control in individuals with type 2 diabetes referred to Zarandeh clinic, Iran. Methods: In this experimental study, 230 individuals with type 2 diabetes (179 female and 51 male) were enrolled and assigned to experimental (n = 115) and control (n = 115) groups...
2018: Diabetology & Metabolic Syndrome
https://www.readbyqxmd.com/read/29758187/antigenic-targets-of-car-t-cell-therapy-a-retrospective-view-on-clinical-trials
#12
REVIEW
Fatemeh Arabi, Monireh Torabi-Rahvar, Ali Shariati, Naser Ahmadbeigi, Mahmood Naderi
Chimeric antigen receptor (CAR) T cell therapy is anticipated to be increasingly implemented in the context of cancer treatment after two current FDA approval of anti-CD19 CAR-T cells (KymriahTM & YescartaTM ). The success of CD19 is mainly attributable to the proper selection of the antigen, CD19, as the target of the disease, highlighting the importance of target selection for other CAR therapies. Therefore, here we performed a global analysis of targets that are the prime focus for various CAR-T cell therapies in human clinical trials...
May 11, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29755625/minimal-invasive-technique-in-atrial-septal-defect-surgery
#13
Feridoun Sabzi, Reza Faraji, Mahmood Kazeminasab
Background: Median sternotomy with minimal skin incision (MSWMSI) and modified anterior mini-thoracotomy (MAMT) approach that both are innovative techniques modified from previous documented techniques are important alternative to conventional median sternotomy in atrial septal defect (ASD) repair. Our aim is to explain the details of two performed techniques in our center and explain the results. Methods: Totally 54 children with ASD (20 female and 34 male) were operated with two different techniques i...
April 2018: Cardiology Research
https://www.readbyqxmd.com/read/29754800/pcyt1a-regulates-phosphatidylcholine-homeostasis-from-the-inner-nuclear-membrane-in-response-to-membrane-stored-curvature-elastic-stress
#14
Afreen Haider, Yu-Chen Wei, Koini Lim, Antonio D Barbosa, Che-Hsiung Liu, Ursula Weber, Marek Mlodzik, Kadri Oras, Simon Collier, M Mahmood Hussain, Liang Dong, Satish Patel, Anna Alvarez-Guaita, Vladimir Saudek, Benjamin J Jenkins, Albert Koulman, Marcus K Dymond, Roger C Hardie, Symeon Siniossoglou, David B Savage
Cell and organelle membranes consist of a complex mixture of phospholipids (PLs) that determine their size, shape, and function. Phosphatidylcholine (PC) is the most abundant phospholipid in eukaryotic membranes, yet how cells sense and regulate its levels in vivo remains unclear. Here we show that PCYT1A, the rate-limiting enzyme of PC synthesis, is intranuclear and re-locates to the nuclear membrane in response to the need for membrane PL synthesis in yeast, fly, and mammalian cells. By aligning imaging with lipidomic analysis and data-driven modeling, we demonstrate that yeast PCYT1A membrane association correlates with membrane stored curvature elastic stress estimates...
May 7, 2018: Developmental Cell
https://www.readbyqxmd.com/read/29754419/integration-of-t-cell-receptor-notch-and-cytokine-signals-programs-in-mouse-%C3%AE-%C3%AE-t-cell-effector-differentiation
#15
Payam Zarin, Tracy S H In, Edward L Y Chen, Jastaranpreet Singh, Gladys W Wong, Mahmood Mohtashami, David L Wiest, Michele K Anderson, Juan Carlos Zúñiga-Pflücker
γδ T-cells perform a wide range of tissue and disease specific functions that are dependent on the effector cytokines produced by these cells. However, the aggregate signals required for the development of interferon-γ (IFNγ) and interleukin-17 (IL-17) producing γδ T-cells remain unknown. Here, we define the cues involved in the functional programming of γδ T-cells, by examining the roles of T-cell receptor (TCR), Notch, and cytokine-receptor signaling. KN6 γδTCR-transduced Rag2-/- T-cell progenitors were cultured on stromal cells variably expressing TCR and Notch ligands, supplemented with different cytokines...
May 13, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29752490/motor-innervation-pattern-of-labral-muscles-of-locusta-migratoria
#16
Abid Mahmood Alvi, Peter Bräunig
The current study investigates the motor innervation pattern of labral muscles in the adult locust and tries to interpret the results in the light of the hypothesis that the labrum phylogenetically developed by the fusion of paired appendages associated with the intercalary segment. Using Neurobiotin™ as a retrograde neuronal tracer, specific motor nerves or individual labral muscles were stained. Results show that the labral muscles receive innervation from tritocerebrum and suboesophageal ganglion. The axons of many motor neurons use three different pathways to cross the midline in the periphery to innervate ipsi- and contralateral muscles...
May 12, 2018: Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology
https://www.readbyqxmd.com/read/29751579/did-lizards-follow-unique-pathways-in-sex-chromosome-evolution
#17
REVIEW
Shayer Mahmood Ibney Alam, Stephen D Sarre, Dianne Gleeson, Arthur Georges, Tariq Ezaz
Reptiles show remarkable diversity in modes of reproduction and sex determination, including high variation in the morphology of sex chromosomes, ranging from homomorphic to highly heteromorphic. Additionally, the co-existence of genotypic sex determination (GSD) and temperature-dependent sex determination (TSD) within and among sister clades makes this group an attractive model to study and understand the evolution of sex chromosomes. This is particularly so with Lizards (Order Squamata) which, among reptiles, show extraordinary morphological diversity...
May 3, 2018: Genes
https://www.readbyqxmd.com/read/29750157/corrigendum-to-natural-treatment-systems-as-sustainable-ecotechnologies-for-the-developing-countries
#18
Qaisar Mahmood, Arshid Pervez, Bibi Saima Zeb, Habiba Zaffar, Hajra Yaqoob, Muhammad Waseem, Zahidullah, Sumera Afsheen
[This corrects the article DOI: 10.1155/2013/796373.].
2018: BioMed Research International
https://www.readbyqxmd.com/read/29750125/vitamin-d-status-and-its-associated-risk-factors-among-adults-in-the-southwest-region-of-cameroon
#19
Delphine A Tangoh, Tobias O Apinjoh, Yasir Mahmood, Robert V Nyingchu, Beatrice A Tangunyi, Emmanuel N Nji, Abid Azhar, Eric A Achidi
Background: Vitamin D has been shown to exert its actions on the musculoskeletal, gastrointestinal, prostate, renal, endocrine, immune, and cardiovascular systems. Current reported data of hypovitaminosis D reveals a global pandemic, with an estimated one billion people worldwide presenting with hypovitaminosis D. Objective: This study aimed at investigating the vitamin D status and its associated risk factors in Cameroonians from the South West Region. Method: The study was a community- and hospital-based prospective longitudinal study...
2018: Journal of Nutrition and Metabolism
https://www.readbyqxmd.com/read/29749981/high-prevalence-of-vitamin-d-deficiency-among-iranian-population-a-systematic-review-and-meta-analysis
#20
REVIEW
Reza Tabrizi, Mahmood Moosazadeh, Maryam Akbari, Mohammad Hossein Dabbaghmanesh, Minoo Mohamadkhani, Zatollah Asemi, Seyed Taghi Heydari, Mojtaba Akbari, Kamran B Lankarani
Background: The prevention and correction of vitamin D deficiency requires a precise depiction of the current situation and identification of risk factors in each region. The present study attempted to determine these entities using a systematic review and meta-analysis in Iran. Methods: Articles published online in Persian and English between 2000 and November 1, 2016, were reviewed. This was carried out using national databases such as SID, IranMedex, Magiran, and IranDoc and international databases such as PubMed, Google Scholar, and Scopus...
March 2018: Iranian Journal of Medical Sciences
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