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Kashif Bashir, Romana Sarwar, Shazia Fatima, Soma Saeed, Ishrat Mahjabeen, Mahmood Akhtar Kayani
PURPOSE: Variants in DNA repair genes may alter the repair mechanisms that make the persons vulnerable to DNA damage. These polymorphic variants in the DNA repair pathway genes, such as XRCC1, have been associated with susceptibility of several types of cancer including thyroid cancer. This study was designed to explore the link between XRCC1 polymorphisms and modulation of thyroid cancer risk. METHODS: Our study consisted of 456 thyroid cancer patients and 400 controls...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Imran Hameed Khaliq, Hafiz Zahid Mahmood, Naveed Akhter, Muhammad Danish Sarfraz, Khadija Asim, Khalid Masood Gondal
PURPOSE: Breast cancer is one of the major causes of death incurring highest morbidity and mortality amongst women of Pakistan. The purpose of this study was to assess and compare the role of two public sector tertiary care hospitals' management in reducing out of pocket (OOP) expenses on direct medical costs borne by breast carcinoma patients' household from diagnosis through treatment. Moreover, the study intended to explore the reasons of opting private diagnostic facilities by the said patients during the services taken from the foresaid tertiary care centers...
January 2018: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
Qiaomu Tian, Jose Antonio Mendez, Laura Rivera-Castaneda, Omar Mahmood, Adam Showalter, Elizabeth Ang, Sarah Kazmi, Huinan Liu
Medical implants play a key role in treating bone fractures. Permanent implants are currently used for immobilization of fractures and bearing physiological loads during bone healing. After bone has healed, these implants, if not removed, often cause complications in the long run; and secondary surgeries for removing them pose additional discomfort and expenses for patients. Magnesium (Mg)-based bioresorbable implants, can potentially eliminate the need for additional surgeries by degrading safely over time in the human body...
April 15, 2018: Materials Letters
Ouajdi Felfoul, Mahmood Mohammadi, Samira Taherkhani, Dominic de Lanauze, Yong Zhong Xu, Michel Lafleur, Louis Gaboury, Maryam Tabrizian, Té Vuong, Gerald Batist, Nicole Beauchemin, Danuta Radzioch, Sylvain Martel
No abstract text is available yet for this article.
March 2018: Médecine Sciences: M/S
Mahmood Karimy, Ahmad Fakhri, Esmaeel Vali, Farzaneh Vali, Feliciano H Veiga, L A R Stein, Marzieh Araban
Background: Growing evidence indicates that if disruptive behavior is left unidentified and untreated, a significant proportion of these problems will persist and may develop into problems linked with delinquency, substance abuse, and violence. Research is needed to develop valid and reliable measures of disruptive behavior to assist recognition and impact of treatments on disruptive behavior. The aim of this study was to develop and evaluate the psychometric properties of a scale for disruptive behavior in adolescents...
2018: Child and Adolescent Psychiatry and Mental Health
Khalid Mahmood, Mukhtar A Memon, Shabbir A Naeem
No abstract text is available yet for this article.
March 2018: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
Mahmood D Al-Mendalawi, Safa A Al-Shaikh
[No Abstract Available].
March 2018: Saudi Medical Journal
Shatha A Al Shanqeeti, Yasser N Alkhudairy, Alwaleed A Alabdulwahed, Anwar E Ahmed, Maysoon S Al-Adham, Naveed M Mahmood
To estimate the prevalence of subclinical hypothyroidism (SCH) in Saudi Arabia and assess the need for an SCH screening program. Methods: This cross-sectional study was conducted at King Abdulaziz Medical City and the Khashmulaan Clinic at the National Guard Health Affairs, Riyadh, Saudi Arabia in August 2016. All women attending the antenatal clinics were  invited to participate in the study. In addition, data were retrieved from the files of pregnant women who had been screened for hypothyroidism from January 2016 to August 2016...
March 2018: Saudi Medical Journal
Mahmood Yousefi, Mehdi Yaseri, Ramin Nabizadeh, Elham Hooshmand, Mohsen Jalilzadeh, Amir Hossein Mahvi, Ali Akbar Mohammadi
Hypertension is becoming a global epidemic for both rural and urban populations; it is a major public health challenge in Iran. Fluoride can be a risk factor for hypertension. Cross-sectional analysis was conducted in two study areas to assess the relation of fluoride with blood pressure prevalence, BMI, waist circumference, and waist-to-hip ratio (WHR) among different age groups in both sexes. The mean value of fluoride concentration in the drinking water from the four study villages varied from 0.68 to 10...
March 14, 2018: Biological Trace Element Research
Vahid Kazemi Moghaddam, Mahmood Yousefi, Ahmad Khosravi, Mehdi Yaseri, Amir Hossein Mahvi, Mostafa Hadei, Ali Akbar Mohammadi, Zahrasadat Robati, Adel Mokammel
The presence of fluoride in drinking water can be either beneficial or harmful for human health, depending on its concentration. Most adverse effects of fluoride are observed at high concentrations (above 1.5 mg/L). This study was aimed to evaluate the effect of fluoride concentrations in drinking water on spontaneous abortion in two regions: one with low fluoride concentration and another with high fluoride concentration. The results showed that there is a relationship between the concentration of fluoride in drinking water and abortion, so that the risk of abortion increased at high concentrations of fluoride...
March 14, 2018: Biological Trace Element Research
Mehdi Ranjbaran, Faeze Mohammadshahi, Sorour Mani, Mahmood Karimy
Background: Tendency toward addiction is provided before drug use begins. The present study aimed to identify the risk factors for addiction potential in the students of Arak University of Medical Sciences. Methods: We conducted this cross-sectional study among 305 students from Arak University of Medical Sciences, Iran in 2016. We selected the students by stratified random sampling and collected the data by family and sociodemographic factors questionnaires and Addiction Potential Scale...
2018: International Journal of Preventive Medicine
Davood Afshari, Seyed Mahmood Latifi, Samira Kord, Maryam Nourollahi-Darabad
In 2011, load limits for manual lifting were adopted in Iran to protect workers from low back injury without prior testing of accuracy with Iranian workers. This investigation examined how accurate the adopted ACGIH TLVs at the allowable limits predict risk for LBP disorders for a group of Iranian workers using biomechanical criteria. Testing took place in the laboratory with participants completing a series of 2-handed lifting tasks as defined in the Iranian Guideline for Manual Lifting. To test accuracy, both compression and shear forces were estimated for fifteen male Iranian workers who completed 25 lift combinations that varied in height and reach with the maximal allowable load...
March 13, 2018: Industrial Health
Mohammad Nauzef Mahmood, Laura H C Peeters, Micha Paalman, Gijsbertus J Verkerke, Idsart Kingma, Jaap H van Dieën
BACKGROUND: Patients with Duchenne muscular dystrophy gradually lose the ability to use different muscles of their body. Consequently, they lose the ability to stabilize their trunk against gravity. This hinders them to effectively perform different daily activities. In this paper, we describe the design, realization and evaluation of a trunk orthosis for these patients that should allow them to move their trunk and maintain stability. METHOD: This study aimed to primarily assess the effectiveness of the trunk support system in terms of unloading of trunk muscles, so only healthy participants were recruited for this phase of the study...
March 14, 2018: Journal of Neuroengineering and Rehabilitation
Golnoosh Ahmadi, Mohsen Shahriari, Mahmood Keyvanara, Shahnaz Kohan
Methods: A qualitative study was used. Midwifery students from three universities in Iran participated. The study used a convenience sample of eighteen students. Data for this study was collected using semi-structured interviews (N=12) and focus groups (N=6). Data were recorded on a digital audio recorder and then transcribed. The qualitative data were analyzed using a content analysis approach. Results: Six broad themes emerged from the analysis: Limited opportunities to experience skills, difficulties with course plan gaps, need for creating a supportive clinical environment, learning drives, confusion between different methods, and stress in the clinical setting...
March 9, 2018: International Journal of Medical Education
Mona Elsafadi, Muthurangan Manikandan, Sami Almalki, Mohammad Mobarak, Muhammad Atteya, Zafar Iqbal, Jamil Amjad Hashmi, Sameerah Shaheen, Nehad Alajez, Musaad Alfayez, Moustapha Kassem, Raed Abu Dawud, Amer Mahmood
TGF β is a potent regulator of several biological functions in many cell types, but its role in the differentiation of human bone marrow-derived skeletal stem cells (hMSCs) is currently poorly understood. In the present study, we demonstrate that a single dose of TGF β 1 prior to induction of osteogenic or adipogenic differentiation results in increased mineralized matrix or increased numbers of lipid-filled mature adipocytes, respectively. To identify the mechanisms underlying this TGF β -mediated enhancement of lineage commitment, we compared the gene expression profiles of TGF β 1-treated hMSC cultures using DNA microarrays...
2018: Stem Cells International
Javed Iqbal, Banzeer Ahsan Abbasi, Riffat Batool, Tariq Mahmood, Barkat Ali, Ali Talha Khalil, Sobia Kanwal, Sayed Afzal Shah, Riaz Ahmad
Breast cancer (BC) is a devastating disease in female around the world causing significant health care burden in both developed and developing countries. In many cases BC has shown resistance to chemotherapy, radiation and hormonal therapy. Development of new, cost effective, affordable treatment method is the need of hour. Chemical compounds isolated from plants are often biologically active and is attracting the attention of scientific community. Different in vitro and in vivo studies have shown a potential role in reducing the risk of cancer metastasis...
March 10, 2018: European Journal of Pharmacology
Hussain N Alhamami, Md Main Uddin, A S M Hasan Mahmood, Karen P Briski
The hypothalamic energy sensor adenosine 5'-monophosphate-activated protein kinase (AMPK), an important regulator of counter-regulatory responses to hypoglycemia, responds to pharmacological manipulation of hindbrain AMPK activity. Dorsomedial hindbrain A2 noradrenergic neurons express hypoglycemia-sensitive metabolo-sensory biomarkers, including AMPK. Here, adult male rats were pretreated by intra-caudal fourth ventricular administration of the selective neurotoxin 6-hydroxydopamine (6-OHDA) to determine if catecholamine signaling from the aforesaid site governs hypothalamic AMPK activation during insulin-induced hypoglycemia (IIH)...
March 10, 2018: Neuroscience
Valiollah Mehrzad, Mehdi Mahmood-Zadeh, Awat Feizi, Arash Raisi
Background: Neutropenic fever and mucositis with 70% outbreak average is one of the major reasons of death in the acute leukemia adult patients. The aim of this study was to determine the relationship of serum zinc level with neutropenic fever and mucositis prevalence in acute leukemia adult patients and comparison of the effects of therapeutic intervention with the serum zinc correct level in the group of patients with zinc deficiency. Materials and Methods: From May 2012 to May 2013 in a double-blind, randomized, placebo-controlled study, on the basis of zinc serum level, 40 acute leukemia adult patients were divided into two groups of normal and deficiency zinc, and neutropenic fever and mucositis prevalence were taken into consideration in each and every group...
2018: Advanced Biomedical Research
Onofrio Antonio Catalano, Vincent Wu, Umar Mahmood, Alberto Signore, Mark Vangel, Andrea Soricelli, Marco Salvatore, Debra Gervais, Bruce R Rosen
This study investigates the performance of PET/MR versus each sub-modality alone in the assessment of active inflammation in patients with Crohn disease, when compared to surgery as standard of reference. Sensitivity for detecting active inflammation was 91.5% for PET, 80% for MR, and 88% for PET/MR. Specificity for active inflammation was 74% for PET, 87% for MR, and 93% for PET/MR. Diagnostic accuracy was 84% for PET, 83% for MR, and 91% for PET/MR. In conclusion, PET/MR is significantly more accurate than either sub-modality alone and more specific than PET alone in the detection of active inflammation in patients with Crohn disease...
2018: American Journal of Nuclear Medicine and Molecular Imaging
Mahmood Dhahir Al-Mendalawi
No abstract text is available yet for this article.
February 2018: Indian Journal of Critical Care Medicine
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