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Peri-implantitis

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https://www.readbyqxmd.com/read/27924602/genome-wide-analysis-of-periodontal-and-peri-implant-cells-and-tissues
#1
Moritz Kebschull, Claudia Hülsmann, Per Hoffmann, Panos N Papapanou
Omics analyses, including the systematic cataloging of messenger RNA and microRNA sequences or DNA methylation patterns in a cell population, organ or tissue sample, are powerful means of generating comprehensive genome-level data sets on complex diseases. We have systematically assessed the transcriptome, miRNome and methylome of gingival tissues from subjects with different diagnostic entities of periodontal disease, and studied the transcriptome of primary cells ex vivo, or in vitro after infection with periodontal pathogens...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/27915981/molecular-cellular-and-pharmaceutical-aspects-of-autologous-grafts-for-peri-implant-hard-and-soft-tissue-defects
#2
Jiayu Lu, Yongming Hao, Wei Zhao, Chengqi Lv, Derong Zou
The lack of supporting hard and soft tissues always prevents the rehabilitation with dental implants. Among various hard and soft tissue augmentation procedures, autologous grafts have been considered to be the gold standard. Autologous mesenchymal stem cells (MSCs) from bone marrow, dental tissue and adipose tissue have been described as promising alternatives for bone regeneration in the field of dental implantation. Mucosal cells, gingival fibroblasts and dental progenitor cells (DPS) can enhance peri-implant soft tissue augmentation and regenerate periodontal tissues around dental implants...
December 1, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27915135/primary-stability-and-viscoelastic-displacement-of-mini-implant-system-under-loading
#3
Jim Lee, Yong-Hoon Jeong, Joseph Pittman, Toru Deguchi, William M Johnston, Henry W Fields, Do-Gyoon Kim
BACKGROUND: The objectives of the current study were to examine the effects of mini-implant diameters on 1) primary stability before bone properties are changed by active peri-implant bone remodeling and 2) the time-dependent displacement of mini-implant systems in bone under a functional radial loading and their associations with bone mineral density. METHODS: Twenty one, 8mm length mini-implants (7 each for 1.4mm, 1.6mm, and 2mm diameters) were placed in mandibular sections of human cadavers (4 males and 3 females, average 69...
November 24, 2016: Clinical Biomechanics
https://www.readbyqxmd.com/read/27898948/%C3%AE-and-%C3%AE-adrenergic-receptors-stimulation-relaxes-porcine-myometrium-in-the-peri-implantation-period
#4
W Markiewicz, J J Jaroszewski
These studies were to demonstrate whether the β-receptor is involved in regulating the contractility of the swine myometrium in the peri-implantation period and to compare a relaxing activity of selective β- and β-adrenergic agonists (salbutamol and BRL 37344, respectively). Myometrial strips were collected form the gilts ( = 8) on d 12 to 14 of pregnancy. Changes in the contractility of myometrial strips were assessed further to the administration of increasing concentrations of the agonists (10 to 10 ) with and without β-adrenergic receptor antagonists: butoxamine, propranolol, and bupranolol at 10 ...
November 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27895679/the-impact-of-body-mass-index-on-dosimetric-quality-in-low-dose-rate-prostate-brachytherapy
#5
Michelle I Echevarria, Arash O Naghavi, Puja S Venkat, Yazan A Abuodeh, Carlos Chevere, Kosj Yamoah
PURPOSE: Low-dose-rate (LDR) brachytherapy has been established as an effective and safe treatment option for men with low and intermediate risk prostate cancer. In this retrospective analysis, we sought to study the effect of body mass index (BMI) on post-implant dosimetric quality. MATERIAL AND METHODS: After institutional approval, records of patients with non-metastatic prostate cancer treated in Puerto Rico with LDR brachytherapy during 2008-2013 were reviewed...
October 2016: Journal of Contemporary Brachytherapy
https://www.readbyqxmd.com/read/27890003/biofilm-mediated-antibiotic-resistant-oral-bacterial
#6
Indu Lata Kanwar, Abhishek Kumar Sah, Preeti K Suresh
Oral diseases like dental caries and periodontal disease are directly associated with the capability of bacteria to form biofilm. Periodontal diseases have been associated to anaerobic Gram-negative bacteria forming a subgingival plaque (Porphyromonas gingivalis, Actinobacillus, Prevotella and Fusobacterium). Biofilm is a complex bacterial community that is highly resistant to antibiotics and human immunity. Biofilm communities are the causative agents of biological developments such as dental caries, periodontitis, and peri-implantitis, and causing periodontal tissue breakdown...
November 24, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27888491/twist-removal-of-healed-vs-nonhealed-implants-a-mechanical-and-histological-study-in-mini-pigs
#7
Ricardo de Oliveira Silva, Fabrício Passador, Paulo Henrique Ferreira Caria
PURPOSE: The objective of this study was to evaluate the effect of removal torque (reverse torque) of titanium implants in peri-implant bone. METHODS: The P1-M1 teeth were extracted bilaterally of 6 mini pigs (BR-1). Each animal received 6 titanium implants, three for each side of mandible. On the right side of mandible, 3 implants reminded 9 months (9M) under masticatory activity and on the left side, other 3 implants were placed and immediately removed (IR). All 36 implants were removed by removal torque, and the recorded values were statistically analyzed...
December 2016: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/27885966/er-cr-ysgg-laser-effectively-ablates-single-species-biofilms-on-titanium-disks-without-detectable-surface-damage
#8
Jason M Strever, Jaebum Lee, William Ealick, Mark Peacock, Daniel Shelby, Cristiano Susin, Donald Mettenberg, Ahmed El-Awady, Frederick Rueggeberg, Christopher W Cutler
BACKGROUND: Increasing evidence implicates biofilms, consisting of species such as Porphyromonas gingivalis, in the etiology of peri-implantitis. Multiple approaches to ablate biofilms on failing implants have been proposed, include the use of lasers; most recently the Er,Cr:YSGG laser. The purpose of this study is to establish an in-vitro single-species biofilm model on implant surfaces and determine power settings of the Er,Cr:YSGG laser that remove the biofilm while not causing physical damage to the disk...
November 25, 2016: Journal of Periodontology
https://www.readbyqxmd.com/read/27884740/effect-of-mechanical-debridement-with-adjunct-antimicrobial-photodynamic-therapy-in-the-treatment-of-peri-implant-diseases-in-type-2-diabetic-smokers-and-non-smokers
#9
Tariq Abduljabbar
OBJECTIVE: The aim of the present 6-month follow-up study was to assess the effect of mechanical debridement (MD) with adjunct antimicrobial photodynamic therapy (aPDT) in the treatment of peri-implant diseases in type-2 diabetic smokers and non-smokers. METHODS: Patients were divided into 2 groups: (a) Group-1: type-2 diabetic smokers; and (b) Group-2: type-2 diabetic non-smokers. In both groups, hemoglobin A1c (HbA1c) levels and peri-implant bleeding on probing (BOP) and probing depth (PD) ≥4mm were measured at baseline and after 6 months of follow-up...
November 21, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27883203/impact-of-platform-switching-on-interproximal-bone-levels-around-8-5-mm-implants-in-the-posterior-region-5-year-results-from-a-randomized-clinical-trial
#10
Gerdien Telleman, Gerry M Raghoebar, Arjan Vissink, Henny J A Meijer
AIM: To assess the medium-term results of 8.5 mm implants supplied with a conventional platform-matched implant-abutment connection or a platform-switched design. MATERIALS & METHODS: Eighty patients with 1 or more missing teeth in the maxillary or mandibular posterior zone were randomly assigned for treatment with implants with a conventional (control group) or platform-switched (test group) implant-abutment connection. Follow-up visits were conducted 1 month, 1 year and 5 years after functional loading...
November 24, 2016: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/27883036/the-mevalonate-pathway-regulates-primitive-streak-formation-via-protein-farnesylation
#11
Yoshimi Okamoto-Uchida, Ruoxing Yu, Norio Miyamura, Norie Arima, Mari Ishigami-Yuasa, Hiroyuki Kagechika, Suguru Yoshida, Takamitsu Hosoya, Makiko Nawa, Takeshi Kasama, Yoichi Asaoka, Reiner Wimmer Alois, Ulrich Elling, Josef M Penninger, Sachiko Nishina, Noriyuki Azuma, Hiroshi Nishina
The primitive streak in peri-implantation embryos forms the mesoderm and endoderm and controls cell differentiation. The metabolic cues regulating primitive streak formation remain largely unknown. Here we utilised a mouse embryonic stem (ES) cell differentiation system and a library of well-characterised drugs to identify these metabolic factors. We found that statins, which inhibit the mevalonate metabolic pathway, suppressed primitive streak formation in vitro and in vivo. Using metabolomics and pharmacologic approaches we identified the downstream signalling pathway of mevalonate and revealed that primitive streak formation requires protein farnesylation but not cholesterol synthesis...
November 24, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27882310/minimal-invasive-horizontal-ridge-augmentation-using-subperiosteal-tunneling-technique
#12
Hyun-Suk Kim, Young-Kyun Kim, Pil-Young Yun
BACKGROUND: The goal of this study was to retrospectively evaluate the prognosis of minimal invasive horizontal ridge augmentation (MIHRA) technique using small incision and subperiosteal tunneling technique. METHODS: This study targeted 25 partially edentulous patients (10 males and 15 females, mean age 48.8 ± 19.7 years) who needed bone graft for installation of the implants due to alveolar bone deficiency. The patients took the radiographic exam, panoramic and periapical view at first visit, and had implant fixture installation surgery...
December 2016: Maxillofacial Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/27880763/inhibition-of-mtor-induces-a-paused-pluripotent-state
#13
Aydan Bulut-Karslioglu, Steffen Biechele, Hu Jin, Trisha A Macrae, Miroslav Hejna, Marina Gertsenstein, Jun S Song, Miguel Ramalho-Santos
Cultured pluripotent stem cells are a cornerstone of regenerative medicine owing to their ability to give rise to all cell types of the body. Although pluripotent stem cells can be propagated indefinitely in vitro, pluripotency is paradoxically a transient state in vivo, lasting 2-3 days around the time of blastocyst implantation. The exception to this rule is embryonic diapause, a reversible state of suspended development triggered by unfavourable conditions. Diapause is a physiological reproductive strategy widely employed across the animal kingdom, including in mammals, but its regulation remains poorly understood...
December 1, 2016: Nature
https://www.readbyqxmd.com/read/27878464/impact-of-abutment-material-on-peri-implant-soft-tissue-color-an-in-vitro-study
#14
Sala Leticia, Bascones-Martínez Antonio, Carrillo-de-Albornoz Ana
OBJECTIVES: The objectives of the present study is to determine the differences in peri-implant soft tissue color with the utilization of titanium, titanium gold-plated, white zirconia, Vita Classical (VC) A4-shaded zirconia, and fluorescent white zirconia abutments and to establish the influence of gingival thickness on the resulting color. METHODS: Four implants were contralaterally inserted in 19 fresh pig mandibles, and the color of the peri-implant mucosa with the different abutments was spectrophotometrically measured at 1-, 2-, and 3-mm height from the margin...
November 22, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27873018/soft-tissue-augmentation-around-osseointegrated-and-uncovered-dental-implants-a-systematic-review
#15
REVIEW
Renzo G Bassetti, Alexandra Stähli, Mario A Bassetti, Anton Sculean
OBJECTIVES: The aim was to compile the current knowledge about the efficacy of different soft tissue correction methods around osseointegrated, already uncovered and/or loaded (OU/L) implants with insufficient soft tissue conditions. Procedures to increase peri-implant keratinized mucosa (KM) width and/or soft tissue volume were considered. MATERIALS AND METHODS: Screening of two databases: MEDLINE (PubMed) and EMBASE (OVID), and manual search of articles were performed...
November 21, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27870923/covering-the-implant-prosthesis-screw-access-hole-a-biological-approach-to-material-selection-and-technique
#16
Todd Schoenbaum, Chandur Wadhwani, Richard Stevenson
The traditional material for covering the implant abutment screw is cotton. As the implant-abutment junction flexes and wears overtime, leakage from the oral environment penetrates into the screw access chamber where the cotton pellet is located. The cotton serves as a scaffolding for the proliferation of anaerobic bacteria in the warm, oxygen free environment. The bacterial exudate causes foul odors and may cause additional inflammation of the peri-implant tissues. The use of PTFE tape or PVS impression material serves the same role as the cotton pellet, but forms a better seal and limits bacterial growth inside the implant and abutment...
November 21, 2016: Journal of Oral Implantology
https://www.readbyqxmd.com/read/27861672/a-two-year-evaluation-of-a-sloped-marginal-contour-implant-system-placed-in-healed-sites
#17
Philip Km Lee, Adam Sc Siu
PURPOSE: The purpose of this clinical trial was to evaluate the survival rate, bone remodeling, and soft tissue health around sloped marginal contour implants when placed in healed sites posteriorly in the mouth. MATERIALS AND METHODS: Implants were placed in healed sites at premolar and molar regions. After a 3-month osseointegration period, definitive prostheses were connected. Clinical and radiographic examinations were performed at implant placement and then 1, 3, 6, 12, and 24 months after implant placement...
November 2016: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/27861666/internal-vs-external-connection-single-implants-a-retrospective-study-in-an-italian-population-treated-by-certified-prosthodontists
#18
Paolo Vigolo, Stefano Gracis, Fabio Carboncini, Sabrina Mutinelli
PURPOSE: The design of an implant connection that allows prosthetic suprastructures to be attached to implants has long been debated in the dental literature. The goal of this retrospective study was to evaluate the 5-year clinical results for a large number of single implants restored by certified prosthodontists in an attempt to establish whether different clinical outcomes could be detected for external- or internal-connection implants. MATERIALS AND METHODS: All single implants with internal or external connections inserted in 27 private dental practices from January 1, 2003 to December 31, 2007 were evaluated...
November 2016: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/27861661/retrospective-cohort-study-of-4-591-straumann-implants-placed-in-2-060-patients-in-private-practice-with-up-to-10-year-follow-up-the-relationship-between-crestal-bone-level-and-soft-tissue-condition
#19
David French, David L Cochran, Ronen Ofec
PURPOSE: The purpose of this report is to describe the crestal bone level (CBL) around implants of various designs, describe the peri-implant soft tissue condition, and evaluate the relationship between the two over time. MATERIALS AND METHODS: This retrospective cohort study reports on 2,060 patients with 4,591 implants evaluated after 3 months; 1, 3, 5, and 7 years; and up to 10 years. Periapical radiographs were used to evaluate changes in CBL. The peri-implant soft tissue was evaluated using a modified Bleeding Index termed the Implant Mucosal Index (IMI) where: 0 = no bleeding; 1 = minimal, single-point bleeding; 2 = moderate, multipoint bleeding; 3 = profuse, multipoint bleeding; and 4 = suppuration...
November 2016: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/27861658/a-comparison-of-tapered-and-nontapered-implants-in-the-minipig
#20
David Cochran, Andreas Stavropoulos, Marcel Obrecht, Benjamin Pippenger, Michel Dard
PURPOSE: Tapered implants are thought to result in equivalent long-term stability and marginal peri-implant bone height in comparison to cylindrical implants. The goal of this study was to compare the primary stability and osseointegration of a novel bone-level tapered-wall implant to a control bone-level cylindrical implant with exactly the same surface characteristics, in a direct side-by-side comparison in an animal model. MATERIALS AND METHODS: Mandibular premolars and first molars were extracted in 11 G...
November 2016: International Journal of Oral & Maxillofacial Implants
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