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https://www.readbyqxmd.com/read/28549195/the-british-society-for-rheumatology-guideline-for-the-management-of-gout
#1
Michelle Hui, Alison Carr, Stewart Cameron, Graham Davenport, Michael Doherty, Harry Forrester, Wendy Jenkins, Kelsey M Jordan, Christian D Mallen, Thomas M McDonald, George Nuki, Anthony Pywell, Weiya Zhang, Edward Roddy
No abstract text is available yet for this article.
May 26, 2017: Rheumatology
https://www.readbyqxmd.com/read/28549177/the-british-society-for-rheumatology-guideline-for-the-management-of-gout
#2
Michelle Hui, Alison Carr, Stewart Cameron, Graham Davenport, Michael Doherty, Harry Forrester, Wendy Jenkins, Kelsey M Jordan, Christian D Mallen, Thomas M McDonald, George Nuki, Anthony Pywell, Weiya Zhang, Edward Roddy
No abstract text is available yet for this article.
May 26, 2017: Rheumatology
https://www.readbyqxmd.com/read/28502328/the-association-between-endocan-levels-and-subclinical-atherosclerosis-in-patients-with-type-2-diabetes-mellitus
#3
Yaya Lv, Yaqiong Zhang, Weiya Shi, Juxiang Liu, Yonghong Li, Zubang Zhou, Qijuan He, Suhong Wei, Jing Liu, Jinxing Quan
BACKGROUND: Proinflammatory conditions induced by circulating factors in diabetes play a pivotal role in endothelial dysfunction and related vascular complications. Endothelial cell-specific molecule-1 or endocan is a dermatan sulfate proteoglycan secreted primarily by the vascular endothelium. Although endocan has been shown to be a potential biomarker in coronary heart disease, its role in the pathogenesis of atherosclerosis (AS) in diabetes remains unclear. In this study, we investigated the correlation between serum endocan levels and subclinical AS in patients with type 2 diabetes mellitus (T2DM)...
May 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28501941/paracrine-release-of-il-2-and-anti-ctla-4-enhances-the-ability-of-artificial-polymer-antigen-presenting-cells-to-expand-antigen-specific-t-cells-and-inhibit-tumor-growth-in-a-mouse-model
#4
Lei Zhang, Limin Wang, Khawar Ali Shahzad, Tao Xu, Xin Wan, Weiya Pei, Chuanlai Shen
Accumulating evidence indicates that bead-based artificial antigen-presenting cells (aAPCs) are a powerful tool to induce antigen-specific T cell responses in vitro and in vivo. To date, most conventional aAPCs have been generated by coupling an antigen signal (signal 1) and one or two costimulatory signals, such as anti-CD28 with anti-LFA1 or anti-4-1BB (signal 2), onto the surfaces of cell-sized or nanoscale magnetic beads or polyester latex beads. The development of a biodegradable scaffold and the combined use of multiple costimulatory signals as well as third signals for putative clinical applications is the next step in the development of this technology...
May 13, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28438380/the-role-of-muscle-strengthening-in-exercise-therapy-for-knee-osteoarthritis-a-systematic-review-and-meta-regression-analysis-of-randomized-trials
#5
REVIEW
Cecilie Bartholdy, Carsten Juhl, Robin Christensen, Hans Lund, Weiya Zhang, Marius Henriksen
OBJECTIVES: To analyze if exercise interventions for patients with knee osteoarthritis (OA) following the American College of Sports Medicine (ACSM) definition of muscle strength training differs from other types of exercise, and to analyze associations between changes in muscle strength, pain, and disability. METHODS: A systematic search in 5 electronic databases was performed to identify randomized controlled trials comparing exercise interventions with no intervention in knee OA, and reporting changes in muscle strength and in pain or disability assessed as standardized mean differences (SMD) with 95% confidence intervals (95% CI)...
March 18, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28389554/eular-recommendations-for-the-use-of-imaging-in-the-clinical-management-of-peripheral-joint-osteoarthritis
#6
Garifallia Sakellariou, Philip G Conaghan, Weiya Zhang, Johannes W J Bijlsma, Pernille Boyesen, Maria Antonietta D'Agostino, Michael Doherty, Daniela Fodor, Margreet Kloppenburg, Falk Miese, Esperanza Naredo, Mark Porcheret, Annamaria Iagnocco
The increased information provided by modern imaging has led to its more extensive use. Our aim was to develop evidence-based recommendations for the use of imaging in the clinical management of the most common arthropathy, osteoarthritis (OA). A task force (including rheumatologists, radiologists, methodologists, primary care doctors and patients) from nine countries defined 10 questions on the role of imaging in OA to support a systematic literature review (SLR). Joints of interest were the knee, hip, hand and foot; imaging modalities included conventional radiography (CR), MRI, ultrasonography, CT and nuclear medicine...
April 7, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28337987/high-performance-and-compact-designed-flexible-thermoelectric-modules-enabled-by-a-reticulate-carbon-nanotube-architecture
#7
Wenbin Zhou, Qingxia Fan, Qiang Zhang, Le Cai, Kewei Li, Xiaogang Gu, Feng Yang, Nan Zhang, Yanchun Wang, Huaping Liu, Weiya Zhou, Sishen Xie
It is a great challenge to substantially improve the practical performance of flexible thermoelectric modules due to the absence of air-stable n-type thermoelectric materials with high-power factor. Here an excellent flexible n-type thermoelectric film is developed, which can be conveniently and rapidly prepared based on the as-grown carbon nanotube continuous networks with high conductivity. The optimum n-type film exhibits ultrahigh power factor of ∼1,500 μW m(-1) K(-2) and outstanding stability in air without encapsulation...
March 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28299460/the-placebo-effect-and-its-determinants-in-fibromyalgia-meta-analysis-of-randomised-controlled-trials
#8
Xi Chen, Kun Zou, Natasya Abdullah, Nicola Whiteside, Aliya Sarmanova, Michael Doherty, Weiya Zhang
The aims of this study were to determine whether placebo treatment in randomised controlled trials (RCTs) is effective for fibromyalgia and to identify possible determinants of the magnitude of any such placebo effect. A systematic literature search was undertaken for RCTs in people with fibromyalgia that included a placebo and/or a no-treatment (observation only or waiting list) control group. Placebo effect size (ES) for pain and other outcomes was measured as the improvement of each outcome from baseline divided by the standard deviation of the change from baseline...
March 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28249762/adsorptive-removal-of-phosphate-from-water-using-mesoporous-materials-a-review
#9
REVIEW
Weiya Huang, Yuanming Zhang, Dan Li
Mesoporous materials have significant potential for use as adsorbents for removal of phosphate from water. The chemical and structural properties of materials greatly affect their capacity and rate in the phosphate adsorption process. This paper reviews recent activities in the development of mesoporous materials as phosphate adsorbents. In particular, it mainly focuses on the synthesis, properties and phosphate removal efficiency of various materials with mesoporosity, including metal-coordinated amino-functionalized silicas, ammonium-functionalized silicas, metal-doped mesoporous silicas, metal oxides, metal sulfate and carbon...
May 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28207850/the-association-between-human-endogenous-retroviruses-and-multiple-sclerosis-a-systematic-review-and-meta-analysis
#10
Elena Morandi, Radu Tanasescu, Rachael E Tarlinton, Cris S Constantinescu, Weiya Zhang, Christopher Tench, Bruno Gran
BACKGROUND: The interaction between genetic and environmental factors is crucial to multiple sclerosis (MS) pathogenesis. Human Endogenous Retroviruses (HERVs) are endogenous viral elements of the human genome whose expression is associated with MS. OBJECTIVE: To perform a systematic review and meta-analysis and to assess qualitative and quantitative evidence on the expression of HERV families in MS patients. METHODS: Medline, Embase and the Cochrane Library were searched for published studies on the association of HERVs and MS...
2017: PloS One
https://www.readbyqxmd.com/read/28165709/epitaxial-growth-of-aligned-and-continuous-carbon-nanofibers-from-carbon-nanotubes
#11
Xiaoyang Lin, Wei Zhao, Wenbin Zhou, Peng Liu, Shu Luo, Haoming Wei, Guangzhi Yang, Junhe Yang, Jie Cui, Richeng Yu, Lina Zhang, Jiaping Wang, Qunqing Li, Weiya Zhou, Weisheng Zhao, Shoushan Fan, Kaili Jiang
Exploiting the superior properties of nanomaterials at macroscopic scale is a key issue of nanoscience. Different from the integration strategy, "additive synthesis" of macroscopic structures from nanomaterial templates may be a promising choice. In this paper, we report the epitaxial growth of aligned, continuous, and catalyst-free carbon nanofiber thin films from carbon nanotube films. The fabrication process includes thickening of continuous carbon nanotube films by gas-phase pyrolytic carbon deposition and further graphitization of the carbon layer by high-temperature treatment...
February 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28160009/familial-aggregation-of-rheumatoid-arthritis-and-co-aggregation-of-autoimmune-diseases-in-affected-families-a-nationwide-population-based-study
#12
Chang-Fu Kuo, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Kuang-Hui Yu, S W Steven Shaw, Shue-Fen Luo, Weiya Zhang, Michael Doherty
Objective.: The aim was to estimate familial relative risk (RR) for RA and other autoimmune diseases and the genetic contribution to RA phenotypic variance (heritability). Methods.: This study used the Taiwan National Health Insurance Research Database to identify all National Health Insurance registered beneficiaries (n = 23 658 577) in 2010; among them, 37 482 individuals had RA. We estimated familial RRs and 95% CIs of RA and other autoimmune diseases using marginal Cox proportional models and heritability of RA using a threshold liability model...
June 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28064207/rheumatoid-arthritis-is-getting-less-frequent-results-of-a-nationwide-population-based-cohort-study
#13
Abhishek Abhishek, Michael Doherty, Chang-Fu Kuo, Christian D Mallen, Weiya Zhang, Matthew J Grainge
OBJECTIVES: The objectives of this study were to examine changes in the incidence and prevalence of RA between 1990 and 2014 and to explore if there is any geographic variation in the incidence and prevalence of RA in the UK. METHODS: This was a primary care-based prospective cohort study. People contributing acceptable data to Clinical Practice Research Datalink between 1 January 1990 and 31 December 2014 were included. Read codes were used to identify RA cases ⩾18 years of age...
January 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28041961/expression-of-angiopoietins-in-central-nervous-system-hemangioblastomas-is-associated-with-cyst-formation
#14
Xiang Li, Wenke Liu, Jianping Liu, Weiya Wang, Si Zhang, Jian Chen, Xuhui Hui
PURPOSE: This study aimed to determine the expression of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and endothelial tyrosine kinase receptor (Tie-2) in central nervous system (CNS) hemangioblastomas (HBs) and explore the correlation with peritumoral cyst formation. METHOD: A total of 22 paraffin-embedded specimens derived from 11 cyst-associated and 11 solid solitary CNS HBs were collected for streptavidin-peroxidase immunohistochemical staining. The expression levels of Ang-1, Ang-2 and Tie-2 in cystic and solid HBs were estimated and compared according to the integrated optical density (IOD) of staining in the sections...
February 3, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28038744/characterization-of-glabridin-hydroxypropyl-%C3%AE-cyclodextrin-inclusion-complex-with-robust-solubility-and-enhanced-bioactivity
#15
Yongqin Wei, Jin Zhang, Yan Zhou, Weiya Bei, Yuan Li, Qipeng Yuan, Hao Liang
Various biological activities of glabridin have been reported in literature, however, the bioavailability and clinical application was limited by its low water solubility. In this study, we developed a novel inclusion complex of glabridin and hydroxypropyl-β-cyclodextrin (HP-β-CD) that features improved solubility and bioactivity. The formation of the inclusion complex was supported by data from FT-IR, PXRD, SEM and NMR. Specifically, the NMR results indicated that the aromatic ring of glabridin was merged into and located at the narrow side the cavity of HP-β-CD...
March 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27995369/responsiveness-of-sf-36-health-survey-and-patient-generated-index-in-people-with-chronic-knee-pain-commenced-on-oral-analgesia-analysis-of-data-from-a-randomised-controlled-clinical-trial
#16
Alex Papou, Salma Hussain, Daniel McWilliams, Weiya Zhang, Michael Doherty
PURPOSE: (1) To assess the responsiveness of the Short Form 36 Health Survey (SF-36) and Patient Generated Index (PGI) in people with knee pain who were given oral analgesics; and (2) to perform content analysis of the SF-36 and PGI aiming to identify differences between the instruments and causes of different responsiveness. METHODS: An observational study nested within a randomised controlled trial comparing oral paracetamol, ibuprofen or a combination of the two in 884 community-derived people with chronic knee pain...
December 19, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27899696/selective-antagonism-of-trpa1-produces-limited-efficacy-in-models-of-inflammatory-and-neuropathic-induced-mechanical-hypersensitivity-in-rats
#17
Sonya G Lehto, Andy D Weyer, Beth D Youngblood, Maosheng Zhang, Ruoyuan Yin, Weiya Wang, Yohannes Teffera, Melanie Cooke, Cheryl L Stucky, Laurie Schenkel, Stephanie Geuns-Meyer, Bryan D Moyer, Kenneth D Wild, Narender R Gavva
The transient receptor potential ankyrin 1 (TRPA1) channel has been implicated in pathophysiological processes that include asthma, cough, and inflammatory pain. Agonists of TRPA1 such as mustard oil and its key component allyl isothiocyanate (AITC) cause pain and neurogenic inflammation in humans and rodents, and TRPA1 antagonists have been reported to be effective in rodent models of pain. In our pursuit of TRPA1 antagonists as potential therapeutics, we generated AMG0902, a potent (IC90 of 300 nM against rat TRPA1), selective, brain penetrant (brain to plasma ratio of 0...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27898816/genome-wide-association-analysis-reveals-different-genetic-control-in-panicle-architecture-between-and-rice
#18
Xufeng Bai, Hu Zhao, Yong Huang, Weibo Xie, Zhongmin Han, Bo Zhang, Zilong Guo, Lin Yang, Haijiao Dong, Weiya Xue, Guangwei Li, Gang Hu, Yong Hu, Yongzhong Xing
Panicle architecture determines the number of spikelets per panicle (SPP) and is highly associated with grain yield in rice ( L.). Understanding the genetic basis of panicle architecture is important for improving the yield of rice grain. In this study, we dissected panicle architecture traits into eight components, which were phenotyped from a germplasm collection of 529 cultivars. Multiple regression analysis revealed that the number of secondary branch (NSB) was the major factor that contributed to SPP. Genome-wide association analysis was performed independently for the eight particle architecture traits observed in the and rice subpopulations compared with the whole rice population...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27872260/familial-aggregation-and-heritability-of-schizophrenia-and-co-aggregation-of-psychiatric-illnesses-in-affected-families
#19
I-Jun Chou, Chang-Fu Kuo, Yu-Shu Huang, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Lu-Shuang Huang, Wen-Yi Tseng, Weiya Zhang, Michael Doherty
Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of schizophrenia, and the relative risks (RRs) of other psychiatric diseases, in relatives of people with schizophrenia using the Taiwan National Health Insurance Database. The study population included individuals with affected first-degree or second-degree relatives identified from all beneficiaries (n = 23 422 955) registered in 2013...
November 21, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27793184/identifying-placebo-responders-and-predictors-of-response-in-osteoarthritis-a-protocol-for-individual-patient-data-meta-analysis
#20
Yu Fu, Monica S M Persson, Archan Bhattacharya, Siew-Li Goh, Joanne Stocks, Marienke van Middelkoop, Sita M A Bierma-Zeinstra, David Walsh, Michael Doherty, Weiya Zhang
BACKGROUND: The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. On average, 75 % of the analgesic effect from OA treatments in clinical trials can be attributed to a placebo response, and this response varies greatly from patient to patient. This individual patient data (IPD) meta-analysis aims to identify placebo responders and the potential determinants of the placebo response in OA...
October 28, 2016: Systematic Reviews
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