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Weiya Zhang

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https://www.readbyqxmd.com/read/28064207/rheumatoid-arthritis-is-getting-less-frequent-results-of-a-nationwide-population-based-cohort-study
#1
Abhishek Abhishek, Michael Doherty, Chang-Fu Kuo, Christian D Mallen, Weiya Zhang, Matthew J Grainge
OBJECTIVES: The objectives of this study were to examine changes in the incidence and prevalence of RA between 1990 and 2014 and to explore if there is any geographic variation in the incidence and prevalence of RA in the UK. METHODS: This was a primary care-based prospective cohort study. People contributing acceptable data to Clinical Practice Research Datalink between 1 January 1990 and 31 December 2014 were included. Read codes were used to identify RA cases ⩾18 years of age...
January 7, 2017: Rheumatology
https://www.readbyqxmd.com/read/28041961/expression-of-angiopoietins-in-central-nervous-system-hemangioblastomas-is-associated-with-cyst-formation
#2
Xiang Li, Wenke Liu, Jianping Liu, Weiya Wang, Si Zhang, Jian Chen, Xuhui Hui
PURPOSE: This study aimed to determine the expression of angiopoietin-1 (Ang-1), angiopoietin-2 (Ang-2), and endothelial tyrosine kinase receptor (Tie-2) in central nervous system (CNS) hemangioblastomas (HBs) and explore the correlation with peritumoral cyst formation. METHOD: A total of 22 paraffin-embedded specimens derived from 11 cyst-associated and 11 solid solitary CNS HBs were collected for streptavidin-peroxidase immunohistochemical staining. The expression levels of Ang-1, Ang-2 and Tie-2 in cystic and solid HBs were estimated and compared according to the integrated optical density (IOD) of staining in the sections...
December 29, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/28038744/characterization-of-glabridin-hydroxypropyl-%C3%AE-cyclodextrin-inclusion-complex-with-robust-solubility-and-enhanced-bioactivity
#3
Yongqin Wei, Jin Zhang, Yan Zhou, Weiya Bei, Yuan Li, Qipeng Yuan, Hao Liang
Various biological activities of glabridin have been reported in literature, however, the bioavailability and clinical application was limited by its low water solubility. In this study, we developed a novel inclusion complex of glabridin and hydroxypropyl-β-cyclodextrin (HP-β-CD) that features improved solubility and bioactivity. The formation of the inclusion complex was supported by data from FT-IR, PXRD, SEM and NMR. Specifically, the NMR results indicated that the aromatic ring of glabridin was merged into and located at the narrow side the cavity of HP-β-CD...
March 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27995369/responsiveness-of-sf-36-health-survey-and-patient-generated-index-in-people-with-chronic-knee-pain-commenced-on-oral-analgesia-analysis-of-data-from-a-randomised-controlled-clinical-trial
#4
Alex Papou, Salma Hussain, Daniel McWilliams, Weiya Zhang, Michael Doherty
PURPOSE: (1) To assess the responsiveness of the Short Form 36 Health Survey (SF-36) and Patient Generated Index (PGI) in people with knee pain who were given oral analgesics; and (2) to perform content analysis of the SF-36 and PGI aiming to identify differences between the instruments and causes of different responsiveness. METHODS: An observational study nested within a randomised controlled trial comparing oral paracetamol, ibuprofen or a combination of the two in 884 community-derived people with chronic knee pain...
December 19, 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27899696/selective-antagonism-of-trpa1-produces-limited-efficacy-in-models-of-inflammatory-and-neuropathic-induced-mechanical-hypersensitivity-in-rats
#5
Sonya G Lehto, Andy D Weyer, Beth D Youngblood, Maosheng Zhang, Ruoyuan Yin, Weiya Wang, Yohannes Teffera, Melanie Cooke, Cheryl L Stucky, Laurie Schenkel, Stephanie Geuns-Meyer, Bryan D Moyer, Kenneth D Wild, Narender R Gavva
The transient receptor potential ankyrin 1 (TRPA1) channel has been implicated in pathophysiological processes that include asthma, cough, and inflammatory pain. Agonists of TRPA1 such as mustard oil and its key component allyl isothiocyanate (AITC) cause pain and neurogenic inflammation in humans and rodents, and TRPA1 antagonists have been reported to be effective in rodent models of pain. In our pursuit of TRPA1 antagonists as potential therapeutics, we generated AMG0902, a potent (IC90 of 300 nM against rat TRPA1), selective, brain penetrant (brain to plasma ratio of 0...
2016: Molecular Pain
https://www.readbyqxmd.com/read/27898816/genome-wide-association-analysis-reveals-different-genetic-control-in-panicle-architecture-between-and-rice
#6
Xufeng Bai, Hu Zhao, Yong Huang, Weibo Xie, Zhongmin Han, Bo Zhang, Zilong Guo, Lin Yang, Haijiao Dong, Weiya Xue, Guangwei Li, Gang Hu, Yong Hu, Yongzhong Xing
Panicle architecture determines the number of spikelets per panicle (SPP) and is highly associated with grain yield in rice ( L.). Understanding the genetic basis of panicle architecture is important for improving the yield of rice grain. In this study, we dissected panicle architecture traits into eight components, which were phenotyped from a germplasm collection of 529 cultivars. Multiple regression analysis revealed that the number of secondary branch (NSB) was the major factor that contributed to SPP. Genome-wide association analysis was performed independently for the eight particle architecture traits observed in the and rice subpopulations compared with the whole rice population...
July 2016: Plant Genome
https://www.readbyqxmd.com/read/27872260/familial-aggregation-and-heritability-of-schizophrenia-and-co-aggregation-of-psychiatric-illnesses-in-affected-families
#7
I-Jun Chou, Chang-Fu Kuo, Yu-Shu Huang, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Lu-Shuang Huang, Wen-Yi Tseng, Weiya Zhang, Michael Doherty
Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of schizophrenia, and the relative risks (RRs) of other psychiatric diseases, in relatives of people with schizophrenia using the Taiwan National Health Insurance Database. The study population included individuals with affected first-degree or second-degree relatives identified from all beneficiaries (n = 23 422 955) registered in 2013...
November 21, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27793184/identifying-placebo-responders-and-predictors-of-response-in-osteoarthritis-a-protocol-for-individual-patient-data-meta-analysis
#8
Yu Fu, Monica S M Persson, Archan Bhattacharya, Siew-Li Goh, Joanne Stocks, Marienke van Middelkoop, Sita M A Bierma-Zeinstra, David Walsh, Michael Doherty, Weiya Zhang
BACKGROUND: The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. On average, 75 % of the analgesic effect from OA treatments in clinical trials can be attributed to a placebo response, and this response varies greatly from patient to patient. This individual patient data (IPD) meta-analysis aims to identify placebo responders and the potential determinants of the placebo response in OA...
October 28, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27729087/familial-risk-of-systemic-sclerosis-and-co-aggregation-of-autoimmune-diseases-in-affected-families
#9
Chang-Fu Kuo, Shue-Fen Luo, Kuang-Hui Yu, Lai-Chu See, Weiya Zhang, Michael Doherty
BACKGROUND: Systemic sclerosis (SSc) is a rare and devastating disease affecting skin and internal organs. Familial aggregation of SSc and co-aggregation with other autoimmune diseases is rarely reported. METHODS: We identified 23,658,577 beneficiaries registered with the National Health Insurance database in 2010, 1891 of whom had SSc. We identified 21,009,551 parent-child relationships and 17,168,340 full sibling pairs. The familial risks of SSc and other autoimmune diseases and familial transmission were estimated...
October 12, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27714203/hydro-actuation-of-hybrid-carbon-nanotube-yarn-muscles
#10
Xiaogang Gu, Qingxia Fan, Feng Yang, Le Cai, Nan Zhang, Wenbin Zhou, Weiya Zhou, Sishen Xie
Hybrid hydro-responsive actuators are developed by infiltrating carbon nanotube yarns using poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate). These actuators demonstrate impressive rotation and contraction in response to water due to volumetric expansion of the helical arrangement of carbon nanotubes. The total torsional stroke is 3720 revolutions per m and the simultaneously generated contractive strain reaches 24% at a paddle-to-yarn mass ratio of 350. The contraction output can furthermore be significantly enhanced by constraining the rotational motion and it reaches 68% with an applied stress of 1 MPa...
October 7, 2016: Nanoscale
https://www.readbyqxmd.com/read/27701424/novel-genetic-variants-for-cartilage-thickness-and-hip-osteoarthritis
#11
Martha C Castaño-Betancourt, Dan S Evans, Yolande F M Ramos, Cindy G Boer, Sarah Metrustry, Youfang Liu, Wouter den Hollander, Jeroen van Rooij, Virginia B Kraus, Michelle S Yau, Braxton D Mitchell, Kenneth Muir, Albert Hofman, Michael Doherty, Sally Doherty, Weiya Zhang, Robert Kraaij, Fernando Rivadeneira, Elizabeth Barrett-Connor, Rose A Maciewicz, Nigel Arden, Rob G H H Nelissen, Margreet Kloppenburg, Joanne M Jordan, Michael C Nevitt, Eline P Slagboom, Deborah J Hart, Floris Lafeber, Unnur Styrkarsdottir, Eleftheria Zeggini, Evangelos Evangelou, Tim D Spector, Andre G Uitterlinden, Nancy E Lane, Ingrid Meulenbelt, Ana M Valdes, Joyce B J van Meurs
Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, we here examined cartilage thickness, one of the structural components of joint health. We conducted a genome-wide association study of minimal joint space width (mJSW), a proxy for cartilage thickness, in a discovery set of 13,013 participants from five different cohorts and replication in 8,227 individuals from seven independent cohorts...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27696728/beta-blocker-use-associates-with-lower-prevalence-of-joint-pain-and-lower-opioid-requirement-in-people-with-osteoarthritis
#12
Ana M Valdes, Abhishek Abhishek, Kenneth Muir, Weiya Zhang, Rose A Maciewicz, Michael Doherty
OBJECTIVE: Recent findings suggest that β-adrenergic blockers have anti-nociceptive properties. The aim of this study was to compare levels of large joint pain between those on adrenergic blockers and those on other antihypertensive medications Methods: Data from the GOAL study, a secondary care cohort of osteoarthritis (OA), were used. Joint pain was assessed using the Western Ontario and McMaster Universities Arthritis (WOMAC) pain score in 873 individuals who had symptomatic hip and/or knee OA and hypertension, and who were on ≥1 prescription antihypertensive medications...
October 1, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27686859/relative-efficacy-of-topical-non-steroidal-anti-inflammatory-drugs-and-topical-capsaicin-in-osteoarthritis-protocol-for-an-individual-patient-data-meta-analysis
#13
Monica S M Persson, Yu Fu, Archan Bhattacharya, Siew-Li Goh, Marienke van Middelkoop, Sita M A Bierma-Zeinstra, David Walsh, Michael Doherty, Weiya Zhang
BACKGROUND: Pain is the most troubling issue to patients with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to identify predictors of treatment response. In line with these recommendations, an individual patient data (IPD) meta-analysis will be conducted. The study aims to investigate the relative treatment effects of topical non-steroidal anti-inflammatory drugs (NSAIDs) and topical capsaicin in OA and to identify patient-level predictors of treatment response...
September 29, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27590834/relative-efficacy-of-different-types-of-exercise-for-treatment-of-knee-and-hip-osteoarthritis-protocol-for-network-meta-analysis-of-randomised-controlled-trials
#14
Siew-Li Goh, Monica S M Persson, Archan Bhattacharya, Michelle Hall, Michael Doherty, Weiya Zhang
BACKGROUND: 'Exercise' is universally recommended as a core treatment for knee and hip osteoarthritis (OA). However, there are very few head-to-head comparative trials to determine the relative efficacy between different types of exercise. The aim of this study is to benchmark different types of exercises against each other through the use of a common comparator in a network meta-analysis of randomised controlled trials (RCTs). METHODS: This study will include only RCTs published in peer-reviewed journals...
2016: Systematic Reviews
https://www.readbyqxmd.com/read/27590234/therapeutic-effects-of-resveratrol-in-a-mouse-model-of-lps-and-cigarette-smoke-induced-copd
#15
Jinlong Chen, Xu Yang, Weiya Zhang, Danhua Peng, Yanan Xia, Yi Lu, Xiaodong Han, Guangjie Song, Jing Zhu, Renping Liu
This study was designed to examine whether resveratrol exerts the protective effects on LPS and cigarette smoke (LC)-induced COPD in a murine model. In lung histopathological studies, H&E, Masson's trichrome, and AB-PAS staining were performed. The cytokines (IL-6, IL-17, TGF-β, and TNF-α) and inflammatory cells in BALF were determined. The Beclin1 level in the lungs of mouse was analyzed. Compared with the LC-induced mouse, the level of inflammatory cytokines (IL-17, IL-6, TNF-α, and TGF-β) of the BALF in the resveratrol + cigarette smoke-treated mouse had obviously decreased...
December 2016: Inflammation
https://www.readbyqxmd.com/read/27588834/early-clinical-features-in-systemic-lupus-erythematosus-can-they-be-used-to-achieve-earlier-diagnosis-a-risk-prediction-model
#16
Frances Rees, Michael Doherty, Peter Lanyon, Graham Davenport, Richard D Riley, Weiya Zhang, Matthew J Grainge
OBJECTIVES: 1) To compare the primary care consulting behaviour prior to diagnosis of people with Systemic Lupus Erythematosus (SLE) with controls, 2) to develop and validate a risk prediction model to aid earlier SLE diagnosis. METHODS: 1,739 incident SLE cases practice-matched to 6,956 controls from the UK Clinical Practice Research Datalink. Odds ratios were calculated for age, gender, consultation rates, selected presenting clinical features and previous diagnoses in the 5 years preceding diagnosis date using logistic regression...
September 2, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27384014/efficient-inhibition-of-hepatitis-b-virus-infection-by-a-pres1-binding-peptide
#17
Xiaoli Ye, Ming Zhou, Yonggang He, Yanmin Wan, Weiya Bai, Shuai Tao, Yanqin Ren, Xinxin Zhang, Jianqing Xu, Jing Liu, Junqi Zhang, Kanghong Hu, Youhua Xie
Entry inhibitors are promising novel antivirals against hepatitis B virus (HBV) infection. The existing potential entry inhibitors have targeted the cellular receptor(s). In this study, we aim to develop the first entry inhibitor that inhibits HBV infection via targeting viral particles. The preS1 segment of the large envelope glycoprotein of HBV is essential for virion attachment and infection. Previously, we obtained a preS1-binding short peptide B10 by screening a phage display peptide library using the N-terminal half of preS1 (residues 1 to 60, genotype C)...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27348572/egfr-mutations-in-non-small-cell-lung-cancer-an-audit-from-west-china-hospital
#18
Yuan Tang, Wei-Ya Wang, Ke Zheng, Lili Jiang, Yan Zou, Xue-Ying Su, Jie Chen, Wen-Yan Zhang, Wei-Ping Liu
OBJECTIVES: To discover the incidence and characteristics of EGFR mutations in non-small cell lung cancer (NSCLC) in a single, large cohort as a part of routine diagnostic investigations. METHODS: We reviewed EGFR mutations investigated by Amplification Refractory Mutation System (ARMS) PCR (covering 29 known mutations) using DNA samples from FFPE tissue or cell clot specimens in a total of 3894 cases of NSCLC analysed between 2012-2014. RESULTS: EGFR mutations are preferentially associated with adenocarcinomaand adenosquamous histology, particularly those well to moderately differentiated, and were significantly more common in female than male patients irrespective of histological subtypes...
August 2016: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/27279864/primary-adrenal-schwannoma-with-catecholamine-hypersecretion
#19
Jianglong Hou, Lizhi Zhang, Yingkun Guo, Huizhu Chen, Weiya Wang
No abstract text is available yet for this article.
June 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27256715/intercritical-circulating-levels-of-neo-epitopes-reflecting-matrixmetalloprotease-driven-degradation-as-markers-of-gout-and-frequent-gout-attacks
#20
Ana M Valdes, Tina Manon-Jensen, Abhishek Abhishek, Wendy Jenkins, Anne Sofie Siebuhr, Morten A Karsdal, Sally Doherty, Weiya Zhang, Helen Richardson, Michael Doherty, Anne-Christine Bay-Jensen
OBJECTIVE: Recurrent flares constitute the main clinical burden of gout. Our aim was to assess whether biomarkers measuring MMP tissue degradation could be used as markers of frequent gout flares. METHODS: Fasting plasma samples from 112 men with gout and 170 controls, along with serum samples from 447 men with gout collected at baseline from an ongoing clinical trial, were analysed by ELISA for neo-epitopes from MMP degradation of collagens type I (C1M) and type III (C3M)...
September 2016: Rheumatology
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