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Weiya Zhang

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https://www.readbyqxmd.com/read/28916715/response-to-different-glucosamine-sulfate-products-generate-different-outcomes-on-osteoarthritis-symptoms-by-reginster-et-al
#1
Jos Runhaar, Rianne M Rozendaal, Marienke van Middelkoop, Hans J W Bijlsma, Michael Doherty, Krysia S Dziedzic, L Stefan Lohmander, Timothy McAlindon, Weiya Zhang, Sita Bierma Zeinstra
No abstract text is available yet for this article.
September 15, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28872930/inconsistence-between-number-and-function-of-autoreactive-t-cells-in-the-course-of-experimental-autoimmune-encephalomyelitis
#2
Xin Wan, Weiya Pei, Yiming Zhang, Lei Zhang, Khawar Ali Shahzad, Tao Xu, Chuanlai Shen
BACKGROUND: Mouse experimental autoimmune encephalomyelitis (EAE) is widely used model of multiple sclerosis (MS). The role of autoreactive CD4(+) and CD8(+) T cells in the development of mouse EAE has been demonstrated. However, little information is available about the relation between the frequency and reactivity of myelin antigen-reactive CD4(+) and CD8(+) T cells in secondary lymphoid organs and their relevance with the inflammation and pathological lesion of CNS during the course of EAE mouse model...
September 5, 2017: Immunological Investigations
https://www.readbyqxmd.com/read/28800620/experimental-study-of-ascs-combined-with-poc-pla-patch-for-the-reconstruction-of-full-thickness-chest-wall-defects
#3
Yuanzheng Zhang, Shuo Fang, Jiezhi Dai, Lei Zhu, Hao Fan, Weiya Tang, Yongjie Fan, Haiying Dai, Peipei Zhang, Ying Wang, Xin Xing, Chao Yang
To explore the repairing effect of combination of adipose stem cells (ASCs) and composite scaffolds on CWR, the electrospun Poly 1, 8-octanediol-co-citric acid (POC)-poly-L-lactide acid (PLA) composite scaffolds were prepared, followed by in vitro and in vivo biocompatibility evaluation of the scaffolds. Afterwards, ASCs were seeded on POC-PLA to construct the POC-PLA-ASCs scaffolds, and the POC-PLA, POC-PLA-ASCs, and traditional materials expanded polytetrafluoroethylene (ePTFE) were adopt for CWR in New Zealand white (NZW) rabbit models...
2017: PloS One
https://www.readbyqxmd.com/read/28754801/subgroup-analyses-of-the-effectiveness-of-oral-glucosamine-for-knee-and-hip-osteoarthritis-a-systematic-review-and-individual-patient-data-meta-analysis-from-the-oa-trial-bank
#4
Jos Runhaar, Rianne M Rozendaal, Marienke van Middelkoop, Hans J W Bijlsma, Michael Doherty, Krysia S Dziedzic, L Stefan Lohmander, Timothy McAlindon, Weiya Zhang, Sita Bierma Zeinstra
OBJECTIVE: To evaluate the effectiveness of oral glucosamine in subgroups of people with hip or knee osteoarthritis (OA) based on baseline pain severity, body mass index (BMI), sex, structural abnormalities and presence of inflammation using individual patient data. METHODS: After a systematic search of the literature and clinical trial registries, all randomised controlled trials (RCTs) evaluating the effect of any oral glucosamine substance in patients with clinically or radiographically defined hip or knee OA were contacted...
July 28, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28736278/efficacy-paradox-and-proportional-contextual-effect-pce
#5
Weiya Zhang, Michael Doherty
The "efficacy paradox" is when the effect of a treatment tested in an RCT, or evidence-based guideline advice, differs markedly from treatment benefits observed in clinical practice. This arises because in RCT reporting and guideline development treatment efficacy is judged by the separation of the treatment group from the placebo group (the specific treatment effect) whereas in clinical practice it is the overall treatment effect, which includes both specific and contextual responses, that patients experience...
July 20, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://www.readbyqxmd.com/read/28691826/cu-catalyzed-aminodifluoroalkylation-of-alkynes-and-%C3%AE-bromodifluoroacetamides
#6
Yunhe Lv, Weiya Pu, Qian Chen, Qingqing Wang, Jiejie Niu, Qian Zhang
The copper-catalyzed highly regioselective aminodifluoroalkylation of alkynes and α-bromodifluoroacetamides was realized for the first time. With this method, 3,3-difluoro-1H-pyrrol-2(3H)-ones were constructed in a single step from various alkynes and α-bromodifluoroacetamides substrates without using any extra oxidant.
July 19, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28678986/association-of-a-family-history-of-atrial-fibrillation-with-incidence-and-outcomes-of-atrial-fibrillation-a-population-based-family-cohort-study
#7
Shang-Hung Chang, Chang-Fu Kuo, I-Jun Chou, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Lu-Hsiang Huang, Weiya Zhang, Michael Doherty, Ming-Shien Wen, Chi-Tai Kuo, Yung-Hsin Yeh
Importance: The heritability of atrial fibrillation (AF), the contribution of genetic and environmental factors, and the association of a family history of AF with prognosis are unclear. Objectives: To measure genetic and environmental factors in the familial aggregation of AF and to estimate the association of a family history of AF with major adverse cardiovascular events (MACE). Design, Setting, and Participants: In this Taiwanese nationwide population-based study among more than 23 million people, a custom data set was obtained using the data of all patients having a diagnosis of AF recorded between January 1996 and December 2013 in the Taiwan National Health Insurance Research Database...
August 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28678807/risk-of-cardiovascular-disease-in-chinese-patients-with-rheumatoid-arthritis-a-cross-sectional-study-based-on-hospital-medical-records-in-10-years
#8
Kun Zou, Fu-Kun Xiao, Hong-Ying Li, Qiao Zhou, Lu Ban, Min Yang, Chang-Fu Kuo, Weiya Zhang
OBJECTIVE: Though the risk of cardiovascular disease (CVD) in rheumatoid arthritis (RA) has been established in Western population, little is known about the risk in Chinese people with RA. Our objective was to estimate the risk of CVD in Chinese people with RA using hospital medical records data. METHODS: The inpatients medical record database 2005-2015 of Sichuan provincial people's hospital was examined. All individuals with a primary diagnosis of RA were included as cases, and those of osteoarthritis (OA) were included as controls, which consisted of the unmatched dataset...
2017: PloS One
https://www.readbyqxmd.com/read/28663061/family-aggregation-and-heritability-of-esrd-in-taiwan-a-population-based-study
#9
Hsin Hsu Wu, Chang Fu Kuo, I Jung Li, Cheng Hao Weng, Cheng Chia Lee, Kun Hua Tu, Shou Hsuan Liu, Yung Chang Chen, Chih Wei Yang, Shue Fen Luo, Lai Chu See, Kuang Hui Yu, Lu Hsiang Huang, Weiya Zhang, Michael Doherty, Ya Chung Tian
BACKGROUND: Aggregation of end-stage renal disease (ESRD) has been observed in families of European origin, as well as those of African origin. However, it is not well documented if this disease aggregates in Asian families. Furthermore, the contribution of genetic factors and shared environmental factors to family aggregation remains unclear. STUDY DESIGN: Population-based cross-sectional cohort study. SETTING & PARTICIPANTS: All 23,422,955 individuals registered in the Taiwan National Health Insurance Research Database in 2013...
June 26, 2017: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
https://www.readbyqxmd.com/read/28655782/ada-07-suppresses-solar-ultraviolet-induced-skin-carcinogenesis-by-directly-inhibiting-topk
#10
Ge Gao, Tianshun Zhang, Qiushi Wang, Kanamata Reddy, Hanyong Chen, Ke Yao, Keke Wang, Eunmiri Roh, Tatyana Zykova, Weiya Ma, Joohyun Ryu, Clara Curiel-Lewandrowski, David Alberts, Sally E Dickinson, Ann M Bode, Ying Xing, Zigang Dong
Cumulative exposure to solar ultraviolet (SUV) irradiation is regarded as the major etiologic factor in the development of skin cancer. The activation of the MAPK cascades occurs rapidly and is vital in the regulation of SUV-induced cellular responses. The T-LAK cell-originated protein kinase (TOPK), an upstream activator of MAPKs, is heavily involved in inflammation, DNA damage, and tumor development. However, the chemopreventive and therapeutic effects of specific TOPK inhibitors in SUV-induced skin cancer have not yet been elucidated...
September 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28605531/the-british-society-for-rheumatology-guideline-for-the-management-of-gout
#11
Michelle Hui, Alison Carr, Stewart Cameron, Graham Davenport, Michael Doherty, Harry Forrester, Wendy Jenkins, Kelsey M Jordan, Christian D Mallen, Thomas M McDonald, George Nuki, Anthony Pywell, Weiya Zhang, Edward Roddy
No abstract text is available yet for this article.
July 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28587375/c-x-c-motif-chemokine-ligand-8-promotes-endothelial-cell-homing-via-the-akt-signal-transducer-and-activator-of-transcription-pathway-to-accelerate-healing-of-ischemic-and-hypoxic-skin-ulcers
#12
Lei Shen, Peng Zhang, Shanqiang Zhang, Liping Xie, Lijie Yao, Weiya Lang, Jie Lian, Wei Qin, Meng Zhang, Liang Ji
C-X-C motif chemokine ligand 8 (CXCL-8) promotes cell homing and angiogenesis. However, under hypoxic conditions, the role of CXCL-8 in the homing of human umbilical vein endothelial cells (HUVECs), and its effect on the healing of skin ulcers caused by ischemia and hypoxia remain unknown. In the current study, assays measuring cell proliferation, in vitro angiogenesis and cell migration were performed to evaluate alterations in the proliferation, angiogenic capacity and chemotaxis of HUVECs treated with CXCL-8 protein and/or an Akt inhibitor (AZD5363 group) under hypoxic conditions...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28549195/the-british-society-for-rheumatology-guideline-for-the-management-of-gout
#13
Michelle Hui, Alison Carr, Stewart Cameron, Graham Davenport, Michael Doherty, Harry Forrester, Wendy Jenkins, Kelsey M Jordan, Christian D Mallen, Thomas M McDonald, George Nuki, Anthony Pywell, Weiya Zhang, Edward Roddy
No abstract text is available yet for this article.
July 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28549177/the-british-society-for-rheumatology-guideline-for-the-management-of-gout
#14
Michelle Hui, Alison Carr, Stewart Cameron, Graham Davenport, Michael Doherty, Harry Forrester, Wendy Jenkins, Kelsey M Jordan, Christian D Mallen, Thomas M McDonald, George Nuki, Anthony Pywell, Weiya Zhang, Edward Roddy
No abstract text is available yet for this article.
July 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28502328/the-association-between-endocan-levels-and-subclinical-atherosclerosis-in-patients-with-type-2-diabetes-mellitus
#15
Yaya Lv, Yaqiong Zhang, Weiya Shi, Juxiang Liu, Yonghong Li, Zubang Zhou, Qijuan He, Suhong Wei, Jing Liu, Jinxing Quan
BACKGROUND: Proinflammatory conditions induced by circulating factors in diabetes play a pivotal role in endothelial dysfunction and related vascular complications. Endothelial cell-specific molecule-1 or endocan is a dermatan sulfate proteoglycan secreted primarily by the vascular endothelium. Although endocan has been shown to be a potential biomarker in coronary heart disease, its role in the pathogenesis of atherosclerosis (AS) in diabetes remains unclear. In this study, we investigated the correlation between serum endocan levels and subclinical AS in patients with type 2 diabetes mellitus (T2DM)...
May 2017: American Journal of the Medical Sciences
https://www.readbyqxmd.com/read/28501941/paracrine-release-of-il-2-and-anti-ctla-4-enhances-the-ability-of-artificial-polymer-antigen-presenting-cells-to-expand-antigen-specific-t-cells-and-inhibit-tumor-growth-in-a-mouse-model
#16
Lei Zhang, Limin Wang, Khawar Ali Shahzad, Tao Xu, Xin Wan, Weiya Pei, Chuanlai Shen
Accumulating evidence indicates that bead-based artificial antigen-presenting cells (aAPCs) are a powerful tool to induce antigen-specific T cell responses in vitro and in vivo. To date, most conventional aAPCs have been generated by coupling an antigen signal (signal 1) and one or two costimulatory signals, such as anti-CD28 with anti-LFA1 or anti-4-1BB (signal 2), onto the surfaces of cell-sized or nanoscale magnetic beads or polyester latex beads. The development of a biodegradable scaffold and the combined use of multiple costimulatory signals as well as third signals for putative clinical applications is the next step in the development of this technology...
May 13, 2017: Cancer Immunology, Immunotherapy: CII
https://www.readbyqxmd.com/read/28438380/the-role-of-muscle-strengthening-in-exercise-therapy-for-knee-osteoarthritis-a-systematic-review-and-meta-regression-analysis-of-randomized-trials
#17
REVIEW
Cecilie Bartholdy, Carsten Juhl, Robin Christensen, Hans Lund, Weiya Zhang, Marius Henriksen
OBJECTIVES: To analyze if exercise interventions for patients with knee osteoarthritis (OA) following the American College of Sports Medicine (ACSM) definition of muscle strength training differs from other types of exercise, and to analyze associations between changes in muscle strength, pain, and disability. METHODS: A systematic search in 5 electronic databases was performed to identify randomized controlled trials comparing exercise interventions with no intervention in knee OA, and reporting changes in muscle strength and in pain or disability assessed as standardized mean differences (SMD) with 95% confidence intervals (95% CI)...
August 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28389554/eular-recommendations-for-the-use-of-imaging-in-the-clinical-management-of-peripheral-joint-osteoarthritis
#18
Garifallia Sakellariou, Philip G Conaghan, Weiya Zhang, Johannes W J Bijlsma, Pernille Boyesen, Maria Antonietta D'Agostino, Michael Doherty, Daniela Fodor, Margreet Kloppenburg, Falk Miese, Esperanza Naredo, Mark Porcheret, Annamaria Iagnocco
The increased information provided by modern imaging has led to its more extensive use. Our aim was to develop evidence-based recommendations for the use of imaging in the clinical management of the most common arthropathy, osteoarthritis (OA). A task force (including rheumatologists, radiologists, methodologists, primary care doctors and patients) from nine countries defined 10 questions on the role of imaging in OA to support a systematic literature review (SLR). Joints of interest were the knee, hip, hand and foot; imaging modalities included conventional radiography (CR), MRI, ultrasonography, CT and nuclear medicine...
September 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28337987/high-performance-and-compact-designed-flexible-thermoelectric-modules-enabled-by-a-reticulate-carbon-nanotube-architecture
#19
Wenbin Zhou, Qingxia Fan, Qiang Zhang, Le Cai, Kewei Li, Xiaogang Gu, Feng Yang, Nan Zhang, Yanchun Wang, Huaping Liu, Weiya Zhou, Sishen Xie
It is a great challenge to substantially improve the practical performance of flexible thermoelectric modules due to the absence of air-stable n-type thermoelectric materials with high-power factor. Here an excellent flexible n-type thermoelectric film is developed, which can be conveniently and rapidly prepared based on the as-grown carbon nanotube continuous networks with high conductivity. The optimum n-type film exhibits ultrahigh power factor of ∼1,500 μW m(-1) K(-2) and outstanding stability in air without encapsulation...
March 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28299460/the-placebo-effect-and-its-determinants-in-fibromyalgia-meta-analysis-of-randomised-controlled-trials
#20
Xi Chen, Kun Zou, Natasya Abdullah, Nicola Whiteside, Aliya Sarmanova, Michael Doherty, Weiya Zhang
The aims of this study were to determine whether placebo treatment in randomised controlled trials (RCTs) is effective for fibromyalgia and to identify possible determinants of the magnitude of any such placebo effect. A systematic literature search was undertaken for RCTs in people with fibromyalgia that included a placebo and/or a no-treatment (observation only or waiting list) control group. Placebo effect size (ES) for pain and other outcomes was measured as the improvement of each outcome from baseline divided by the standard deviation of the change from baseline...
July 2017: Clinical Rheumatology
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