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Michael Doherty

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https://www.readbyqxmd.com/read/29459986/hydroxychloroquine-effectiveness-in-reducing-symptoms-of-hand-osteoarthritis-a-randomized-trial
#1
Sarah R Kingsbury, Puvan Tharmanathan, Ada Keding, Sarah J Ronaldson, Andrew Grainger, Richard J Wakefield, Catherine Arundel, Fraser Birrell, Michael Doherty, Tonia Vincent, Fiona E Watt, Krysia Dziedzic, Terence W O'Neill, Nigel K Arden, David L Scott, John Dickson, Toby Garrood, Michael Green, Ajit Menon, Tom Sheeran, David Torgerson, Philip G Conaghan
Background: Synovitis is believed to play a role in producing symptoms in persons with hand osteoarthritis, but data on slow-acting anti-inflammatory treatments are sparse. Objective: To determine the effectiveness of hydroxychloroquine versus placebo as an analgesic treatment of hand osteoarthritis. Design: Randomized, double-blind, placebo-controlled clinical trial with 12-month follow-up. (ISRCTN registry number: ISRCTN91859104). Setting: 13 primary and secondary care centers in England...
February 20, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29438225/traits-associated-with-central-pain-augmentation-in-the-knee-pain-in-the-community-kpic-cohort
#2
Kehinde Akin-Akinyosoye, Nadia Frowd, Laura Marshall, Joanne Stocks, Gwen Fernandes, Ana Valdes, Daniel F McWilliams, Weiya Zhang, Michael Doherty, Eamonn Ferguson, David A Walsh
This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n=420) in the Knee Pain and related health In the Community (KPIC) baseline survey undertook pressure pain threshold (PPT) assessments. Items measuring specific traits related to central pain mechanisms were selected from the survey based on expert consensus, face validity, item association to underlying constructs measured by originating host questionnaires, adequate targeting and PPT correlations...
February 9, 2018: Pain
https://www.readbyqxmd.com/read/29436380/relative-efficacy-and-safety-of-topical-non-steroidal-anti-inflammatory-drugs-for-osteoarthritis-a-systematic-review-and-network-meta-analysis-of-randomised-controlled-trials-and-observational-studies
#3
REVIEW
Chao Zeng, Jie Wei, Monica S M Persson, Aliya Sarmanova, Michael Doherty, Dongxing Xie, YiLun Wang, Xiaoxiao Li, Jiatian Li, Huizhong Long, Guanghua Lei, Weiya Zhang
OBJECTIVES: To compare the efficacy and safety of topical non-steroidal anti-inflammatory drugs (NSAIDs), including salicylate, for the treatment of osteoarthritis (OA). METHODS: PubMed, Embase, Cochrane Library and Web of Science were searched from 1966 to January 2017. Randomised controlled trials (RCTs) comparing topical NSAIDs with placebo or each other in patients with OA and observational studies comparing topical NSAIDs with no treatment or each other irrespective of disease were included...
February 7, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29435177/prostate-selective-%C3%AE-antagonists-increase-fracture-risk-in-prostate-cancer-patients-with-and-without-a-history-of-androgen-deprivation-therapy-a-nationwide-population-based-study
#4
Wei-Heng Kao, Chang-Fu Kuo, I-Jun Chou, Lai-Chu See, Wen-Kuan Huang, Meng-Jiun Chiou, Weiya Zhang, Michael Doherty, Chun-Chieh Wang, Jun-Te Hsu, Hsien-Hsin Chen, Ji-Hong Hong
Introductions: Prostate-selective α antagonists are recommended for relief of lower urinary tract symptoms in prostate cancer patients despite uncertainty of fracture risk as an addition to androgen deprivation therapy (ADT). The purpose of this study is to estimate fracture risk associated with these medications in prostate cancer patients who did and did not receive ADT. Methods: The Taiwan National Health Insurance database was used to identify prostate cancer patients...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29395023/is-there-a-role-for-ytrrium-90-in-the-treatment-of-unresectable-and-metastatic-intrahepatic-cholangiocarcinoma
#5
Tamer M Shaker, Chloe Chung, Manish K Varma, Michael G Doherty, Andrea M Wolf, Mathew H Chung, M Mura Assifi
BACKGROUND: Selective internal radiation therapy (SIRT) with Ytrrium-90 (Y-90) has been used to treat hepatic malignancies with success. This study focuses on the efficacy and safety of Y-90 in the treatment of unresectable and metastatic intrahepatic cholangiocarcinoma (ICC). METHODS: A single-institution retrospective case review was performed for patients with unresectable and metastatic ICC treated with Y-90 between 2006 and 2016. RESULTS: Seventeen patients with ICC underwent 21 Y-90 treatments...
January 30, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29315623/tnf-family-member-light-acts-with-il-1%C3%AE-and-tgf-%C3%AE-to-promote-airway-remodeling-during-rhinovirus-infection
#6
Amit K Mehta, Taylor Doherty, David Broide, Michael Croft
BACKGROUND: Rhinovirus (RV) can exacerbate allergen-driven asthma. However, it has been suggested that serial infections with RV may also lead to asthma-like features in childhood without prior allergen exposure. AIM: We sought to test the effects of RV infection in the absence of allergen challenge on lung tissue remodeling and to understand if RV induced factors in common with allergen that promote remodeling. METHODS: We infected C57BL/6 mice multiple times with RV in the absence or presence of allergen to assess airway remodeling...
January 9, 2018: Allergy
https://www.readbyqxmd.com/read/29311331/ion-dissolution-mechanism-and-kinetics-at-kink-sites-on-nacl-surfaces
#7
Mark N Joswiak, Michael F Doherty, Baron Peters
Desolvation barriers are present for solute-solvent exchange events, such as ligand binding to an enzyme active site, during protein folding, and at battery electrodes. For solution-grown crystals, desolvation at kink sites can be the rate-limiting step for growth. However, desolvation and the associated kinetic barriers are poorly understood. In this work, we use rare-event simulation techniques to investigate attachment/detachment events at kink sites of a NaCl crystal in water. We elucidate the desolvation mechanism and present an optimized reaction coordinate, which involves one solute collective variable and one solvent collective variable...
January 8, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29290291/a-discussion-of-calibration-techniques-for-evaluating-binary-and-categorical-predictive-models
#8
REVIEW
Caroline Fenlon, Luke O'Grady, Michael L Doherty, John Dunnion
Modelling of binary and categorical events is a commonly used tool to simulate epidemiological processes in veterinary research. Logistic and multinomial regression, naïve Bayes, decision trees and support vector machines are popular data mining techniques used to predict the probabilities of events with two or more outcomes. Thorough evaluation of a predictive model is important to validate its ability for use in decision-support or broader simulation modelling. Measures of discrimination, such as sensitivity, specificity and receiver operating characteristics, are commonly used to evaluate how well the model can distinguish between the possible outcomes...
January 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29287118/serum-n-propeptide-of-collagen-iia-piianp-as-a-marker-of-radiographic-osteoarthritis-burden
#9
Hikmat N Daghestani, Joanne M Jordan, Jordan B Renner, Michael Doherty, A Gerry Wilson, Virginia B Kraus
OBJECTIVE: Cartilage homeostasis relies on a balance of catabolism and anabolism of cartilage matrix. Our goal was to evaluate the burden of radiographic osteoarthritis and serum levels of type IIA procollagen amino terminal propeptide (sPIIANP), a biomarker representing type II collagen synthesis, in osteoarthritis. METHODS: OA burden was quantified on the basis of radiographic features as total joint faces with an osteophyte, joint space narrowing, or in the spine, disc space narrowing...
2017: PloS One
https://www.readbyqxmd.com/read/29275348/subgrouping-and-targeted-exercise-programmes-for-knee-and-hip-osteoarthritis-steer-oa-a-systematic-review-update-and-individual-participant-data-meta-analysis-protocol
#10
Melanie A Holden, Danielle L Burke, Jos Runhaar, Danielle van Der Windt, Richard D Riley, Krysia Dziedzic, Amardeep Legha, Amy L Evans, J Haxby Abbott, Kristin Baker, Jenny Brown, Kim L Bennell, Daniël Bossen, Lucie Brosseau, Kanda Chaipinyo, Robin Christensen, Tom Cochrane, Mariette de Rooij, Michael Doherty, Helen P French, Sheila Hickson, Rana S Hinman, Marijke Hopman-Rock, Michael V Hurley, Carol Ingram, Jesper Knoop, Inga Krauss, Chris McCarthy, Stephen P Messier, Donald L Patrick, Nilay Sahin, Laura A Talbot, Robert Taylor, Carolien H Teirlinck, Marienke van Middelkoop, Christine Walker, Nadine E Foster
INTRODUCTION: Knee and hip osteoarthritis (OA) is a leading cause of disability worldwide. Therapeutic exercise is a recommended core treatment for people with knee and hip OA, however, the observed effect sizes for reducing pain and improving physical function are small to moderate. This may be due to insufficient targeting of exercise to subgroups of people who are most likely to respond and/or suboptimal content of exercise programmes. This study aims to identify: (1) subgroups of people with knee and hip OA that do/do not respond to therapeutic exercise and to different types of exercise and (2) mediators of the effect of therapeutic exercise for reducing pain and improving physical function...
December 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29258575/association-between-ultrasound-detected-synovitis-and-knee-pain-a-population-based-case-control-study-with-both-cross-sectional-and-follow-up-data
#11
Aliya Sarmanova, Michelle Hall, Gwen S Fernandes, Archan Bhattacharya, Ana M Valdes, David A Walsh, Michael Doherty, Weiya Zhang
BACKGROUND: An important role for synovial pathology in the initiation and progression of knee osteoarthritis has been emphasised recently. This study aimed to examine whether ultrasonography-detected synovial changes associate with knee pain (KP) in a community population. METHODS: A case-control study was conducted to compare people with early KP (n = 298), established KP (n = 100) or no KP (n = 94) at baseline. Multinomial logistic regression was used to estimate the odds ratio (OR) and 95% confidence interval (CI) between groups adjusted for radiographic osteoarthritis (ROA) severity and other confounding factors...
December 19, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29247577/ovarian-cancer-risk-aldh2-polymorphism-and-alcohol-drinking-asian-data-from-the-ovarian-cancer-association-consortium
#12
Tomotaka Ugai, Linda E Kelemen, Mika Mizuno, Jue-Sheng Ong, Penelope M Webb, Georgia Chenevix-Trench, Kristine G Wicklund, Jennifer Anne Doherty, Mary Anne Rossing, Pamela J Thompson, Lynne R Wilkens, Michael E Carney, Marc T Goodman, Joellen M Schildkraut, Andrew Berchuck, Daniel W Cramer, Kathryn L Terry, Hui Cai, Xiao-Ou Shu, Yu-Tang Gao, Yong-Bing Xiang, David Van Den Berg, Malcom C Pike, Anna H Wu, Celeste Leigh Pearce, Keitaro Matsuo
The ALDH2 polymorphism rs671 (Glu504Lys) causes ALDH2 inactivation and adverse acetaldehyde exposure among Asians, but little is known of the association between alcohol consumption and rs671 and ovarian cancer (OvCa) in Asians. We conducted a pooled analysis of Asian ancestry participants in the Ovarian Cancer Association Consortium. We included seven case-control studies and one cohort study comprising 460 invasive OvCa cases, 37 borderline mucinous OvCa and 1,274 controls of Asian descent with information on recent alcohol consumption...
December 16, 2017: Cancer Science
https://www.readbyqxmd.com/read/29234466/the-effect-of-variation-in-interpretation-of-the-la-trobe-radiographic-foot-atlas-on-the-prevalence-of-foot-osteoarthritis-in-older-women-the-chingford-general-population-cohort
#13
Peter McQueen, Lucy Gates, Michelle Marshall, Michael Doherty, Nigel Arden, Catherine Bowen
Background: The prevalence of foot osteoarthritis (OA) is much less understood than hip, knee and hand OA. The foot is anatomically complex and different researchers have investigated different joints with lack of methodological standardisation across studies. The La Trobe Foot Atlas (LFA) is the first to address these issues in providing quantitative assessment of radiographic foot OA, but has not been tested externally. The aim of this study was to evaluate three different interpretive approaches to using the LFA for grading OA when scoring is difficult due to indistinct views of interosseous space and joint contour...
2017: Journal of Foot and Ankle Research
https://www.readbyqxmd.com/read/29220880/development-of-a-new-biochip-array-for-apoe4-classification-from-plasma-samples-using-immunoassay-based-methods
#14
Sigrun Badrnya, Tara Doherty, Ciaran Richardson, Robert I McConnell, John V Lamont, Michael Veitinger, Stephen P FitzGerald, Maria Zellner, Ellen Umlauf
BACKGROUND: Apolipoprotein E (APOE) is a key player in lipid transport and metabolism and exists in three common isoforms: APOE2, APOE3 and APOE4. The presence of the E4 allelic variant is recognized as a major genetic risk factor for dementia and other chronic (neuro)degenerative diseases. The availability of a validated assay for rapid and reliable APOE4 classification is therefore advantageous. METHODS: Biochip array technology (BAT) was successfully applied to identify directly the APOE4 status from plasma within 3 h, through simultaneous immunoassay-based detection of both specific APOE4 and total APOE levels...
December 7, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29208732/the-next-generation-of-training-for-arabidopsis-researchers-bioinformatics-and-quantitative-biology
#15
Joanna Friesner, Sarah M Assmann, Ruth Bastow, Julia Bailey-Serres, Jim Beynon, Volker Brendel, C Robin Buell, Alexander Bucksch, Wolfgang Busch, Taku Demura, Jose R Dinneny, Colleen J Doherty, Andrea L Eveland, Pascal Falter-Braun, Malia A Gehan, Michael Gonzales, Erich Grotewold, Rodrigo Gutierrez, Ute Kramer, Gabriel Krouk, Shisong Ma, R J Cody Markelz, Molly Megraw, Blake C Meyers, James A H Murray, Nicholas J Provart, Sue Rhee, Roger Smith, Edgar P Spalding, Crispin Taylor, Tracy K Teal, Keiko U Torii, Chris Town, Matthew Vaughn, Richard Vierstra, Doreen Ware, Olivia Wilkins, Cranos Williams, Siobhan M Brady
No abstract text is available yet for this article.
December 2017: Plant Physiology
https://www.readbyqxmd.com/read/29201347/the-creation-and-evaluation-of-a-model-to-simulate-the-probability-of-conception-in-seasonal-calving-pasture-based-dairy-heifers
#16
Caroline Fenlon, Luke O'Grady, Stephen Butler, Michael L Doherty, John Dunnion
Background: Herd fertility in pasture-based dairy farms is a key driver of farm economics. Models for predicting nulliparous reproductive outcomes are rare, but age, genetics, weight, and BCS have been identified as factors influencing heifer conception. The aim of this study was to create a simulation model of heifer conception to service with thorough evaluation. Methods: Artificial Insemination service records from two research herds and ten commercial herds were provided to build and evaluate the models...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/29198909/hiv-1-drug-resistance-before-initiation-or-re-initiation-of-first-line-antiretroviral-therapy-in-low-income-and-middle-income-countries-a-systematic-review-and-meta-regression-analysis
#17
Ravindra K Gupta, John Gregson, Neil Parkin, Hiwot Haile-Selassie, Amilcar Tanuri, Liliana Andrade Forero, Pontiano Kaleebu, Christine Watera, Avelin Aghokeng, Nicholus Mutenda, Janet Dzangare, San Hone, Zaw Zaw Hang, Judith Garcia, Zully Garcia, Paola Marchorro, Enrique Beteta, Amalia Giron, Raph Hamers, Seth Inzaule, Lisa M Frenkel, Michael H Chung, Tulio de Oliveira, Deenan Pillay, Kogie Naidoo, Ayesha Kharsany, Ruthiran Kugathasan, Teresa Cutino, Gillian Hunt, Santiago Avila Rios, Meg Doherty, Michael R Jordan, Silvia Bertagnolio
BACKGROUND: Pretreatment drug resistance in people initiating or re-initiating antiretroviral therapy (ART) containing non-nucleoside reverse transcriptase inhibitors (NNRTIs) might compromise HIV control in low-income and middle-income countries (LMICs). We aimed to assess the scale of this problem and whether it is associated with the intiation or re-initiation of ART in people who have had previous exposure to antiretroviral drugs. METHODS: This study was a systematic review and meta-regression analysis...
November 30, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29198315/mimicking-the-effects-of-spaceflight-on-bone-combined-effects-of-disuse-and-chronic-low-dose-rate-radiation-exposure-on-bone-mass-in-mice
#18
Kanglun Yu, Alison H Doherty, Paula C Genik, Sara E Gookin, Danielle M Roteliuk, Samantha J Wojda, Zhi-Sheng Jiang, Meghan E McGee-Lawrence, Michael M Weil, Seth W Donahue
During spaceflight, crewmembers are subjected to biomechanical and biological challenges including microgravity and radiation. In the skeleton, spaceflight leads to bone loss, increasing the risk of fracture. Studies utilizing hindlimb suspension (HLS) as a ground-based model of spaceflight often neglect the concomitant effects of radiation exposure, and even when radiation is accounted for, it is often delivered at a high-dose rate over a very short period of time, which does not faithfully mimic spaceflight conditions...
November 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29198264/international-quality-improvement-initiatives
#19
Patricia A Hickey, Jean A Connor, Kotturathu M Cherian, Kathy Jenkins, Kaitlin Doherty, Haibo Zhang, Michael Gaies, Sara Pasquali, Sarah Tabbutt, James D St Louis, George E Sarris, Hiromi Kurosawa, Richard A Jonas, Nestor Sandoval, Christo I Tchervenkov, Jeffery P Jacobs, Giovanni Stellin, James K Kirklin, Rajnish Garg, David F Vener
Across the globe, the implementation of quality improvement science and collaborative learning has positively affected the care and outcomes for children born with CHD. These efforts have advanced the collective expertise and performance of inter-professional healthcare teams. In this review, we highlight selected quality improvement initiatives and strategies impacting the field of cardiovascular care and describe implications for future practice and research. The continued leveraging of technology, commitment to data transparency, focus on team-based practice, and recognition of cultural norms and preferences ensure the success of sustainable models of global collaboration...
December 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29190847/adverse-maternal-and-neonatal-outcomes-in-indicated-compared-with-spontaneous-preterm-birth-in-healthy-nulliparas-a-secondary-analysis-of-a-randomized-trial
#20
Alan T Tita, Lindsay Doherty, Jim M Roberts, Leslie Myatt, Kenneth J Leveno, Michael W Varner, Ronald J Wapner, John M Thorp, Brian M Mercer, Alan Peaceman, Susan M Ramin, Marshall W Carpenter, Jay Iams, Anthony Sciscione, Margaret Harper, Jorge E Tolosa, George R Saade, Yoram Sorokin
No abstract text is available yet for this article.
November 30, 2017: American Journal of Perinatology
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