keyword
MENU ▼
Read by QxMD icon Read
search

Michael Doherty

keyword
https://www.readbyqxmd.com/read/27908116/energetic-and-entropic-components-of-the-tolman-length-for-mw-and-tip4p-2005-water-nanodroplets
#1
Mark N Joswiak, Ryan Do, Michael F Doherty, Baron Peters
The surface free energy of a droplet is approximately γ(R)=γ(∞)(1-2δ/R), with R being the droplet radius and δ being the Tolman length. Here we use the mitosis method to compute δ=-0.56±0.1Å at 300 K for mW water, indicating that γ(R) increases as the droplet size decreases. The computed Tolman length agrees quite well with a previous study of TIP4P/2005 water. We also decompose the size-dependent surface free energy into energetic and entropic contributions for the mW and TIP4P/2005 force fields...
November 28, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/27878478/liver-resection-after-selective-internal-radiation-therapy-with-yttrium-90-is-safe-and-feasible-a-bi-institutional-analysis
#2
G Paul Wright, J Wallis Marsh, Manish K Varma, Michael G Doherty, David L Bartlett, Mathew H Chung
BACKGROUND: Treatment with yttrium-90 (Y90) microspheres has emerged as a viable liver-directed therapy for patients with unresectable tumors and those outside transplantation criteria. A select number of patients demonstrate a favorable response and become candidates for surgical resection. METHODS: Patients who underwent selective internal radiation therapy (SIRT) with Y90 microspheres at two institutions were reviewed. Patients who underwent liver resection were included in the study...
November 22, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/27872260/familial-aggregation-and-heritability-of-schizophrenia-and-co-aggregation-of-psychiatric-illnesses-in-affected-families
#3
I-Jun Chou, Chang-Fu Kuo, Yu-Shu Huang, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Lu-Shuang Huang, Wen-Yi Tseng, Weiya Zhang, Michael Doherty
Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of schizophrenia, and the relative risks (RRs) of other psychiatric diseases, in relatives of people with schizophrenia using the Taiwan National Health Insurance Database. The study population included individuals with affected first-degree or second-degree relatives identified from all beneficiaries (n = 23 422 955) registered in 2013...
November 21, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27862567/large-scale-multi-directional-larval-connectivity-among-coral-reef-fish-populations-in-the-great-barrier-reef-marine-park
#4
David H Williamson, Hugo B Harrison, Glenn R Almany, Michael L Berumen, Michael Bode, Mary C Bonin, Severine Choukroun, Peter J Doherty, Ashley J Frisch, Pablo Saenz-Agudelo, Geoffrey P Jones
Larval dispersal is the key process by which populations of most marine fishes and invertebrates are connected and replenished. Advances in larval tagging and genetics have enhanced our capacity to track larval dispersal, assess scales of population connectivity, and quantify larval exchange among no-take marine reserves and fished areas. Recent studies have found that reserves can be a significant source of recruits for populations up to 40 km away, but the scale and direction of larval connectivity across larger seascapes remain unknown...
November 11, 2016: Molecular Ecology
https://www.readbyqxmd.com/read/27856332/allergy-and-infant-feeding-guidelines-in-the-context-of-resource-constrained-settings
#5
Michael Levin, Ameena Goga, Tanya Doherty, Hoosen Coovadia, David Sanders, Robin J Green, Sharon Kling
No abstract text is available yet for this article.
November 14, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27852956/preparation-for-a-first-in-man-lentivirus-trial-in-patients-with-cystic-fibrosis
#6
Eric W F W Alton, Jeffery M Beekman, A Christopher Boyd, June Brand, Marianne S Carlon, Mary M Connolly, Mario Chan, Sinead Conlon, Heather E Davidson, Jane C Davies, Lee A Davies, Johanna F Dekkers, Ann Doherty, Sabrina Gea-Sorli, Deborah R Gill, Uta Griesenbach, Mamoru Hasegawa, Tracy E Higgins, Takashi Hironaka, Laura Hyndman, Gerry McLachlan, Makoto Inoue, Stephen C Hyde, J Alastair Innes, Toby M Maher, Caroline Moran, Cuixiang Meng, Michael C Paul-Smith, Ian A Pringle, Kamila M Pytel, Andrea Rodriguez-Martinez, Alexander C Schmidt, Barbara J Stevenson, Stephanie G Sumner-Jones, Richard Toshner, Shu Tsugumine, Marguerite W Wasowicz, Jie Zhu
We have recently shown that non-viral gene therapy can stabilise the decline of lung function in patients with cystic fibrosis (CF). However, the effect was modest, and more potent gene transfer agents are still required. Fuson protein (F)/Hemagglutinin/Neuraminidase protein (HN)-pseudotyped lentiviral vectors are more efficient for lung gene transfer than non-viral vectors in preclinical models. In preparation for a first-in-man CF trial using the lentiviral vector, we have undertaken key translational preclinical studies...
November 16, 2016: Thorax
https://www.readbyqxmd.com/read/27828972/coral-reefs-and-people-in-a-high-co2-world-where-can-science-make-a-difference-to-people
#7
Linwood Pendleton, Adrien Comte, Chris Langdon, Julia A Ekstrom, Sarah R Cooley, Lisa Suatoni, Michael W Beck, Luke M Brander, Lauretta Burke, Josh E Cinner, Carolyn Doherty, Peter E T Edwards, Dwight Gledhill, Li-Qing Jiang, Ruben J van Hooidonk, Louise Teh, George G Waldbusser, Jessica Ritter
REEFS AND PEOPLE AT RISK: Increasing levels of carbon dioxide in the atmosphere put shallow, warm-water coral reef ecosystems, and the people who depend upon them at risk from two key global environmental stresses: 1) elevated sea surface temperature (that can cause coral bleaching and related mortality), and 2) ocean acidification. These global stressors: cannot be avoided by local management, compound local stressors, and hasten the loss of ecosystem services. Impacts to people will be most grave where a) human dependence on coral reef ecosystems is high, b) sea surface temperature reaches critical levels soonest, and c) ocean acidification levels are most severe...
2016: PloS One
https://www.readbyqxmd.com/read/27793184/identifying-placebo-responders-and-predictors-of-response-in-osteoarthritis-a-protocol-for-individual-patient-data-meta-analysis
#8
Yu Fu, Monica S M Persson, Archan Bhattacharya, Siew-Li Goh, Joanne Stocks, Marienke van Middelkoop, Sita M A Bierma-Zeinstra, David Walsh, Michael Doherty, Weiya Zhang
BACKGROUND: The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. On average, 75 % of the analgesic effect from OA treatments in clinical trials can be attributed to a placebo response, and this response varies greatly from patient to patient. This individual patient data (IPD) meta-analysis aims to identify placebo responders and the potential determinants of the placebo response in OA...
October 28, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27791084/wildfire-climate-and-invasive-grass-interactions-negatively-impact-an-indicator-species-by-reshaping-sagebrush-ecosystems
#9
Peter S Coates, Mark A Ricca, Brian G Prochazka, Matthew L Brooks, Kevin E Doherty, Travis Kroger, Erik J Blomberg, Christian A Hagen, Michael L Casazza
Iconic sagebrush ecosystems of the American West are threatened by larger and more frequent wildfires that can kill sagebrush and facilitate invasion by annual grasses, creating a cycle that alters sagebrush ecosystem recovery post disturbance. Thwarting this accelerated grass-fire cycle is at the forefront of current national conservation efforts, yet its impacts on wildlife populations inhabiting these ecosystems have not been quantified rigorously. Within a Bayesian framework, we modeled 30 y of wildfire and climatic effects on population rates of change of a sagebrush-obligate species, the greater sage-grouse, across the Great Basin of western North America...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27753711/an-international-interprofessional-study-of-mental-models-and-factors-delaying-neuroimaging-of-critically-head-injured-children-presenting-to-emergency-departments
#10
Marc Auerbach, Joanne Cole, Pina Violano, Linda Roney, Catherine Doherty, Michael Shepherd, Ralph MacKinnon
OBJECTIVES: Thousands of head-injured children are cared for by interprofessional teams in emergency departments every day. Teams must balance performing time-consuming interventions with safe transport for neuroimaging. This study aims to describe and compare providers' perspectives on the transfer of head-injured children to neuroimaging and factors contributing to delays. METHODS: Participants were interprofessional health care providers involved in the care of head-injured children at sites in the United Kingdom, the United States, and New Zealand...
October 8, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27744254/teenage-motherhood-where-you-live-is-also-important-a-prospective-cohort-study-of-14-000-women
#11
David M Wright, Michael Rosato, Rachel Doherty, Dermot O'Reilly
The United Kingdom has among the highest rates of teenage motherhood (TM) in Western Europe. The relationship to individual social and material disadvantage is well established but the influence of area of residence is unclear. We tested for additional TM risks in deprived areas or in cities. The Northern Ireland Longitudinal Study was used to identify 14,055 nulliparous females (15-18). TM risk was measured using multilevel logistic regression, adjusting for health status, religion, family structure, socio-economic status, rurality and employment-based area deprivation...
November 2016: Health & Place
https://www.readbyqxmd.com/read/27744128/assessing-occurrence-of-hypoglycemia-and-its-severity-from-electronic-health-records-of-patients-with-type-2-diabetes-mellitus
#12
Anthony P Nunes, Jing Yang, Larry Radican, Samuel S Engel, Karen Kurtyka, Kaan Tunceli, Shengsheng Yu, Kristy Iglay, Michael C Doherty, David D Dore
AIMS: Accurate measures of hypoglycemia within electronic health records (EHR) can facilitate clinical population management and research. We quantify the occurrence of serious and mild-to-moderate hypoglycemia in a large EHR database in the US, comparing estimates based only on structured data to those from structured data and natural language processing (NLP) of clinical notes. METHODS: This cohort study included patients with type 2 diabetes identified from January 2009 through March 2014...
September 21, 2016: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/27729087/familial-risk-of-systemic-sclerosis-and-co-aggregation-of-autoimmune-diseases-in-affected-families
#13
Chang-Fu Kuo, Shue-Fen Luo, Kuang-Hui Yu, Lai-Chu See, Weiya Zhang, Michael Doherty
BACKGROUND: Systemic sclerosis (SSc) is a rare and devastating disease affecting skin and internal organs. Familial aggregation of SSc and co-aggregation with other autoimmune diseases is rarely reported. METHODS: We identified 23,658,577 beneficiaries registered with the National Health Insurance database in 2010, 1891 of whom had SSc. We identified 21,009,551 parent-child relationships and 17,168,340 full sibling pairs. The familial risks of SSc and other autoimmune diseases and familial transmission were estimated...
October 12, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27720537/mortality-among-men-with-advanced-prostate-cancer-excluded-from-the-protect-trial
#14
Thomas J Johnston, Greg L Shaw, Alastair D Lamb, Deepak Parashar, David Greenberg, Tengbin Xiong, Alison L Edwards, Vincent Gnanapragasam, Peter Holding, Phillipa Herbert, Michael Davis, Elizabeth Mizielinsk, J Athene Lane, Jon Oxley, Mary Robinson, Malcolm Mason, John Staffurth, Prasad Bollina, James Catto, Andrew Doble, Alan Doherty, David Gillatt, Roger Kockelbergh, Howard Kynaston, Steve Prescott, Alan Paul, Philip Powell, Derek Rosario, Edward Rowe, Jenny L Donovan, Freddie C Hamdy, David E Neal
BACKGROUND: Early detection and treatment of asymptomatic men with advanced and high-risk prostate cancer (PCa) may improve survival rates. OBJECTIVE: To determine outcomes for men diagnosed with advanced PCa following prostate-specific antigen (PSA) testing who were excluded from the ProtecT randomised trial. DESIGN, SETTING, AND PARTICIPANTS: Mortality was compared for 492 men followed up for a median of 7.4 yr to a contemporaneous cohort of men from the UK Anglia Cancer Network (ACN) and with a matched subset from the ACN...
October 6, 2016: European Urology
https://www.readbyqxmd.com/read/27716335/feasibility-of-community-level-interventions-for-pre-eclampsia-perspectives-knowledge-and-task-sharing-from-nigeria-mozambique-pakistan-and-india
#15
Mary V Kinney, Jeffrey Michael Smith, Tanya Doherty, Jorge Hermida, Karen Daniels, José M Belizán
Hypertensive disorders of pregnancy (HDP), particularly pre-eclampsia and eclampsia, remain one of the leading causes of maternal mortality and are contributory in many foetal/newborn deaths. This editorial discusses a supplement of seven papers which provide the results of the first round of the CLIP (Community Level Interventions for Pre-eclampsia) Feasibility Studies. These studies report a number of enablers and barriers in each setting, which have informed the implementation of a cluster-randomized trial (cRCT) aimed at reducing pre-eclampsia-related, and all-cause, maternal and perinatal mortality and major morbidity using community-based identification and treatment of pre-eclampsia in selected geographies of Nigeria, Mozambique, Pakistan and India...
September 30, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27701424/novel-genetic-variants-for-cartilage-thickness-and-hip-osteoarthritis
#16
Martha C Castaño-Betancourt, Dan S Evans, Yolande F M Ramos, Cindy G Boer, Sarah Metrustry, Youfang Liu, Wouter den Hollander, Jeroen van Rooij, Virginia B Kraus, Michelle S Yau, Braxton D Mitchell, Kenneth Muir, Albert Hofman, Michael Doherty, Sally Doherty, Weiya Zhang, Robert Kraaij, Fernando Rivadeneira, Elizabeth Barrett-Connor, Rose A Maciewicz, Nigel Arden, Rob G H H Nelissen, Margreet Kloppenburg, Joanne M Jordan, Michael C Nevitt, Eline P Slagboom, Deborah J Hart, Floris Lafeber, Unnur Styrkarsdottir, Eleftheria Zeggini, Evangelos Evangelou, Tim D Spector, Andre G Uitterlinden, Nancy E Lane, Ingrid Meulenbelt, Ana M Valdes, Joyce B J van Meurs
Osteoarthritis is one of the most frequent and disabling diseases of the elderly. Only few genetic variants have been identified for osteoarthritis, which is partly due to large phenotype heterogeneity. To reduce heterogeneity, we here examined cartilage thickness, one of the structural components of joint health. We conducted a genome-wide association study of minimal joint space width (mJSW), a proxy for cartilage thickness, in a discovery set of 13,013 participants from five different cohorts and replication in 8,227 individuals from seven independent cohorts...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27698005/risk-prediction-for-epithelial-ovarian-cancer-in-11-united-states-based-case-control-studies-incorporation-of-epidemiologic-risk-factors-and-17-confirmed-genetic-loci
#17
Merlise A Clyde, Rachel Palmieri Weber, Edwin S Iversen, Elizabeth M Poole, Jennifer A Doherty, Marc T Goodman, Roberta B Ness, Harvey A Risch, Mary Anne Rossing, Kathryn L Terry, Nicolas Wentzensen, Alice S Whittemore, Hoda Anton-Culver, Elisa V Bandera, Andrew Berchuck, Michael E Carney, Daniel W Cramer, Julie M Cunningham, Kara L Cushing-Haugen, Robert P Edwards, Brooke L Fridley, Ellen L Goode, Galina Lurie, Valerie McGuire, Francesmary Modugno, Kirsten B Moysich, Sara H Olson, Celeste Leigh Pearce, Malcolm C Pike, Joseph H Rothstein, Thomas A Sellers, Weiva Sieh, Daniel Stram, Pamela J Thompson, Robert A Vierkant, Kristine G Wicklund, Anna H Wu, Argyrios Ziogas, Shelley S Tworoger, Joellen M Schildkraut
Previously developed models for predicting absolute risk of invasive epithelial ovarian cancer have included a limited number of risk factors and have had low discriminatory power (area under the receiver operating characteristic curve (AUC) < 0.60). Because of this, we developed and internally validated a relative risk prediction model that incorporates 17 established epidemiologic risk factors and 17 genome-wide significant single nucleotide polymorphisms (SNPs) using data from 11 case-control studies in the United States (5,793 cases; 9,512 controls) from the Ovarian Cancer Association Consortium (data accrued from 1992 to 2010)...
October 15, 2016: American Journal of Epidemiology
https://www.readbyqxmd.com/read/27696728/beta-blocker-use-associates-with-lower-prevalence-of-joint-pain-and-lower-opioid-requirement-in-people-with-osteoarthritis
#18
Ana M Valdes, Abhishek Abhishek, Kenneth Muir, Weiya Zhang, Rose A Maciewicz, Michael Doherty
OBJECTIVE: Recent findings suggest that β-adrenergic blockers have anti-nociceptive properties. The aim of this study was to compare levels of large joint pain between those on adrenergic blockers and those on other antihypertensive medications Methods: Data from the GOAL study, a secondary care cohort of osteoarthritis (OA), were used. Joint pain was assessed using the Western Ontario and McMaster Universities Arthritis (WOMAC) pain score in 873 individuals who had symptomatic hip and/or knee OA and hypertension, and who were on ≥1 prescription antihypertensive medications...
October 1, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27686859/relative-efficacy-of-topical-non-steroidal-anti-inflammatory-drugs-and-topical-capsaicin-in-osteoarthritis-protocol-for-an-individual-patient-data-meta-analysis
#19
Monica S M Persson, Yu Fu, Archan Bhattacharya, Siew-Li Goh, Marienke van Middelkoop, Sita M A Bierma-Zeinstra, David Walsh, Michael Doherty, Weiya Zhang
BACKGROUND: Pain is the most troubling issue to patients with osteoarthritis (OA), yet current pharmacological treatments offer only small-to-moderate pain reduction. Current guidelines therefore emphasise the need to identify predictors of treatment response. In line with these recommendations, an individual patient data (IPD) meta-analysis will be conducted. The study aims to investigate the relative treatment effects of topical non-steroidal anti-inflammatory drugs (NSAIDs) and topical capsaicin in OA and to identify patient-level predictors of treatment response...
September 29, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27668181/individualizing-therapies-with-responsive-epilepsy-neurostimulation-a-mirtazapine-case-study-of-hippocampal-excitability
#20
Nicole M Warner, Ryder P Gwinn, Michael J Doherty
OBJECTIVES: This study aimed to investigate mirtazapine-induced changes in responsive neurostimulator (RNS) recordings in a patient with epilepsy. MATERIALS AND METHODS: Cortical detection/stimulation counts from an RNS implanted in a patient with bitemporal epilepsy were matched to mirtazapine use to see if that drug altered hippocampal excitability. RESULTS: Mirtazapine decreased hippocampal stability; when mirtazapine was held after a washout period, DSC counts declined, but when it was retrialed, DSC counts increased...
2016: Epilepsy & Behavior Case Reports
keyword
keyword
80041
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"