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Michael Doherty

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https://www.readbyqxmd.com/read/29922084/bidirectional-association-between-disturbed-sleep-and-neuropathic-pain-symptoms-a-prospective-cohort-study-in-post-total-joint-replacement-participants
#1
Joanne Stocks, Nicole Ky Tang, David A Walsh, Sophie C Warner, Hollie L Harvey, Wendy Jenkins, Abhishek Abhishek, Michael Doherty, Ana M Valdes
Background: Disturbed sleep is strongly correlated with chronic pain. The aim of this study was to examine the association between sleep disturbance and incident joint pain focusing on neuropathic-like pain symptoms. Methods: A total of 423 individuals who had undergone total joint replacement (TJR) for osteoarthritis were assessed at the mean time of 3.6 years post-surgery and again at 5.9 years post-TJR, using the Medical Outcomes Survey sleep subscale, Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and painDETECT questionnaire instruments...
2018: Journal of Pain Research
https://www.readbyqxmd.com/read/29917100/conventional-and-biologic-disease-modifying-anti-rheumatic-drugs-for-osteoarthritis-a-meta-analysis-of-randomized-controlled-trials
#2
Monica S M Persson, Aliya Sarmanova, Michael Doherty, Weiya Zhang
Objectives: The role of inflammation in OA is controversial and it is unclear whether suppressing inflammation with conventional or biologic DMARDs is effective. A systematic review and meta-analysis of randomized controlled trials (RCTs) was conducted to compare DMARDs with placebo in participants with symptomatic OA. Methods: Databases (Medline, Embase, Allied and Complementary Medicine Database, Web of Science and Cochrane Library), conference abstracts and ClinicalTrials...
June 16, 2018: Rheumatology
https://www.readbyqxmd.com/read/29901743/predictors-and-temporal-trend-of-flu-vaccination-in-auto-immune-rheumatic-diseases-in-the-uk-a-nationwide-prospective-cohort-study
#3
Georgina Nakafero, Matthew J Grainge, Puja R Myles, Christian D Mallen, Weiya Zhang, Michael Doherty, Jonathan S Nguyen-Van-Tam, Abhishek Abhishek
Objectives: To examine temporal trend in uptake of seasonal influenza vaccine (SIV) in the UK and explore disease and demographic factors associated with vaccination. Methods: From the Clinical Practice Research Datalink, 32 751 people with auto-immune rheumatic diseases prescribed DMARDs between 2006 and 2016 were identified. The proportion vaccinated between 1 September of one year and 31 March of the next year was calculated and stratified by age, other indications for vaccination, auto-immune rheumatic diseases type and number of DMARDs prescribed...
June 12, 2018: Rheumatology
https://www.readbyqxmd.com/read/29895892/large-scale-mapping-of-cortical-alterations-in-22q11-2-deletion-syndrome-convergence-with-idiopathic-psychosis-and-effects-of-deletion-size
#4
Daqiang Sun, Christopher R K Ching, Amy Lin, Jennifer K Forsyth, Leila Kushan, Ariana Vajdi, Maria Jalbrzikowski, Laura Hansen, Julio E Villalon-Reina, Xiaoping Qu, Rachel K Jonas, Therese van Amelsvoort, Geor Bakker, Wendy R Kates, Kevin M Antshel, Wanda Fremont, Linda E Campbell, Kathryn L McCabe, Eileen Daly, Maria Gudbrandsen, Clodagh M Murphy, Declan Murphy, Michael Craig, Jacob Vorstman, Ania Fiksinski, Sanne Koops, Kosha Ruparel, David R Roalf, Raquel E Gur, J Eric Schmitt, Tony J Simon, Naomi J Goodrich-Hunsaker, Courtney A Durdle, Anne S Bassett, Eva W C Chow, Nancy J Butcher, Fidel Vila-Rodriguez, Joanne Doherty, Adam Cunningham, Marianne B M van den Bree, David E J Linden, Hayley Moss, Michael J Owen, Kieran C Murphy, Donna M McDonald-McGinn, Beverly Emanuel, Theo G M van Erp, Jessica A Turner, Paul M Thompson, Carrie E Bearden
The 22q11.2 deletion (22q11DS) is a common chromosomal microdeletion and a potent risk factor for psychotic illness. Prior studies reported widespread cortical changes in 22q11DS, but were generally underpowered to characterize neuroanatomic abnormalities associated with psychosis in 22q11DS, and/or neuroanatomic effects of variability in deletion size. To address these issues, we developed the ENIGMA (Enhancing Neuro Imaging Genetics Through Meta-Analysis) 22q11.2 Working Group, representing the largest analysis of brain structural alterations in 22q11DS to date...
June 13, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29879383/introduction
#5
Rachel A Segalman, Michael F Doherty
No abstract text is available yet for this article.
June 7, 2018: Annual Review of Chemical and Biomolecular Engineering
https://www.readbyqxmd.com/read/29806203/monosodium-urate-crystal-deposits-are-common-in-asymptomatic-sons-of-people-with-gout-the-sons-of-gout-study
#6
Abhishek Abhishek, Philip Courtney, Wendy Jenkins, Gabriela Sandoval-Plata, Adrian C Jones, Weiya Zhang, Michael Doherty
OBJECTIVE: To estimate the prevalence and distribution of asymptomatic monosodium urate (MSU) crystal deposition in sons of people with gout. METHOD: People with gout were mailed an explanatory letter enclosing a postage-paid study-pack to mail to their son(s) ≥20 years old. Sons interested in participating returned a reply-slip and underwent telephone screening. Subsequently they attended a study-visit for blood and urine collection, and musculoskeletal ultrasonography performed blind to serum urate (SU)...
May 27, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29796636/rheumatoid-arthritis-and-excess-mortality-down-but-not-out-a-primary-care-cohort-study-using-data-from-clinical-practice-research-datalink
#7
Abhishek Abhishek, Georgina Nakafero, Chang-Fu Kuo, Christian Mallen, Weiya Zhang, Matthew J Grainge, Michael Doherty
Objectives: To examine temporal trends in all-cause and cause-specific mortality in RA. Methods: Data from the Clinical Practice Research Datalink were used. Incident RA cases and four age-, sex- and general practice-matched controls were identified from at-risk cohorts for each calendar year and followed-up for up to 5 years. Mortality rates and 95% CIs were computed. Cox proportional hazard ratios (HRs) were calculated to estimate associations and adjusted for covariates...
June 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29770428/teaching-preschool-children-to-report-suspicious-packages-to-adults
#8
Michael E May, Ashley M Shayter, Ayla Schmick, Becky Barron, Meghan Doherty, Matthew Johnson
Law enforcement agencies stress that public reporting of terror-related crime is the predominant means for disrupting these actions. However, schools may be unprepared because the majority of the populace may not understand the threat of suspicious materials or what to do when they are found on school grounds. The purpose of this study was to systematically teach preschool children to identify and report suspicious packages across three experiments. In the first experiment, we used multiple exemplar training to teach children to identify the characteristics of safe and unsafe packages...
May 16, 2018: Journal of Applied Behavior Analysis
https://www.readbyqxmd.com/read/29770149/diffuse-gastric-ganglioneuromatosis-novel-presentation-of-pten-hamartoma-syndrome-case-report-and-review-of-gastric-ganglioneuromatous-proliferations-and-a-novel-pten-gene-mutation
#9
Alexander J Williams, Emily S Doherty, Michael H Hart, Douglas J Grider
Gastrointestinal ganglioneuromatous proliferations are rare, most often found in the colon, and are three types: polypoid ganglioneuromas, ganglioneuromatous polyposis, and diffuse ganglioneuromatosis. We present a case of diffuse ganglioneuromatosis in the posterior gastric wall in a nine-year-old female. To our knowledge, this is the first reported case of diffuse ganglioneuromatosis located in the stomach. Only six cases of gastric ganglioneuromatous proliferations have previously been reported, two in English and none were diffuse ganglioneuromatosis...
2018: Case Reports in Medicine
https://www.readbyqxmd.com/read/29770136/cd3%C3%AE%C2%B5-expression-defines-functionally-distinct-subsets-of-v%C3%AE-1-t-cells-in-patients-with-human-immunodeficiency-virus-infection
#10
Pádraic J Dunne, Christina O Maher, Michael Freeley, Katie Dunne, Andreea Petrasca, Judy Orikiiriza, Margaret R Dunne, Derval Reidy, Siobhan O'Dea, Aisling Loy, Jim Woo, Aideen Long, Thomas R Rogers, Fiona Mulcahy, Derek G Doherty
Human γδ T cells expressing the Vδ1 T cell receptor (TCR) recognize self and microbial antigens and stress-inducible molecules in a major histocompatibility complex-unrestricted manner and are an important source of innate interleukin (IL)-17. Vδ1 T cells are expanded in the circulation and intestines of patients with human immunodeficiency virus (HIV) infection. In this study, we show that patients with HIV have elevated frequencies, but not absolute numbers, of circulating Vδ1 T cells compared to control subjects...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29748278/recent-asian-origin-of-chytrid-fungi-causing-global-amphibian-declines
#11
Simon J O'Hanlon, Adrien Rieux, Rhys A Farrer, Gonçalo M Rosa, Bruce Waldman, Arnaud Bataille, Tiffany A Kosch, Kris A Murray, Balázs Brankovics, Matteo Fumagalli, Michael D Martin, Nathan Wales, Mario Alvarado-Rybak, Kieran A Bates, Lee Berger, Susanne Böll, Lola Brookes, Frances Clare, Elodie A Courtois, Andrew A Cunningham, Thomas M Doherty-Bone, Pria Ghosh, David J Gower, William E Hintz, Jacob Höglund, Thomas S Jenkinson, Chun-Fu Lin, Anssi Laurila, Adeline Loyau, An Martel, Sara Meurling, Claude Miaud, Pete Minting, Frank Pasmans, Dirk S Schmeller, Benedikt R Schmidt, Jennifer M G Shelton, Lee F Skerratt, Freya Smith, Claudio Soto-Azat, Matteo Spagnoletti, Giulia Tessa, Luís Felipe Toledo, Andrés Valenzuela-Sánchez, Ruhan Verster, Judit Vörös, Rebecca J Webb, Claudia Wierzbicki, Emma Wombwell, Kelly R Zamudio, David M Aanensen, Timothy Y James, M Thomas P Gilbert, Ché Weldon, Jaime Bosch, François Balloux, Trenton W J Garner, Matthew C Fisher
Globalized infectious diseases are causing species declines worldwide, but their source often remains elusive. We used whole-genome sequencing to solve the spatiotemporal origins of the most devastating panzootic to date, caused by the fungus Batrachochytrium dendrobatidis , a proximate driver of global amphibian declines. We traced the source of B. dendrobatidis to the Korean peninsula, where one lineage, Bd ASIA-1, exhibits the genetic hallmarks of an ancestral population that seeded the panzootic. We date the emergence of this pathogen to the early 20th century, coinciding with the global expansion of commercial trade in amphibians, and we show that intercontinental transmission is ongoing...
May 11, 2018: Science
https://www.readbyqxmd.com/read/29729332/does-the-intensity-of-daily-walking-matter-for-protecting-against-the-development-of-a-slow-gait-speed-in-people-with-or-at-high-risk-of-knee-osteoarthritis-an-observational-study
#12
S A M Fenton, T Neogi, D Dunlop, M Nevitt, M Doherty, J L Duda, R Klocke, A Abhishek, A Rushton, W Zhang, C E Lewis, J Torner, G Kitas, D K White
OBJECTIVE: Knee osteoarthritis (OA) is a risk factor for a decline in gait speed. Daily walking reduces the risk of developing slow gait speed and future persistent functional limitation. However, the protective role of walking intensity is unclear. We investigated the association of substituting time spent not walking, with walking at light and moderate-to-vigorous intensities for incident slow gait over 2-years, among people with or at high risk of OA. METHOD: We used baseline and 2-year follow-up data from the Multicenter Osteoarthritis (MOST) study (n = 1731) and the Osteoarthritis Initiative (OAI, n = 1925)...
May 2, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29721020/detection-of-hiv-1-and-human-proteins-in-urinary-extracellular-vesicles-from-hiv-patients
#13
Samuel I Anyanwu, Akins Doherty, Michael D Powell, Chamberlain Obialo, Ming B Huang, Alexander Quarshie, Claudette Mitchell, Khalid Bashir, Gale W Newman
Background: Extracellular vesicles (EVs) are membrane bound, secreted by cells, and detected in bodily fluids, including urine, and contain proteins, RNA, and DNA. Our goal was to identify HIV and human proteins (HPs) in urinary EVs from HIV+ patients and compare them to HIV- samples. Methods: Urine samples were collected from HIV+ ( n = 35) and HIV- ( n = 12) individuals. EVs were isolated by ultrafiltration and characterized using transmission electron microscopy, tandem mass spectrometry (LC/MS/MS), and nanoparticle tracking analysis (NTA)...
2018: Advances in Virology
https://www.readbyqxmd.com/read/29692968/pilot-data-on-responsive-epilepsy-neurostimulation-measures-of-sleep-apnea-and-continuous-glucose-measurements
#14
Katie M Kinnear, Nicole M Warner, Anand Gersappe, Michael J Doherty
Objectives: To match responsive neurostimulator (RNS) and polysomnographic data to determine if RNS detections and stimulations correlate with measurements of sleep disordered breathing and continuous glucose measurements (CGM). Materials and methods: In a patient with an RNS with detection/stimulation leads implanted bi-temporally detection-stimulation counts were matched by time with coinciding polysomnogram and CGM data. Results: Temporal dispersion of RNS DSC were independent of measures of sleep apnea, hypopnea or glucose...
2018: Epilepsy & Behavior Case Reports
https://www.readbyqxmd.com/read/29669335/antenatal-corticosteroid-exposure-disrupts-myelination-in-the-auditory-nerve-of-preterm-sheep
#15
Judith Rittenschober-Böhm, Jennifer Rodger, Alan H Jobe, Suhas G Kallapur, Dorota A Doherty, Boris W Kramer, Matthew S Payne, Michael Archer, Christian Rittenschober, John P Newnham, Yuichiro Miura, Angelika Berger, Stephen G Matthews, Matthew W Kemp
BACKGROUND: Antenatal corticosteroids (ACS) improve preterm neonatal outcomes. However, uncertainty remains regarding the safety of ACS exposure for the developing fetus, particularly its neurosensory development. OBJECTIVES: We investigated the effect of single and multiple ACS exposures on auditory nerve development in an ovine model of pregnancy. METHODS: Ewes with a single fetus (gestational age [GA] 100 days) received an intramuscular injection of 150 mg medroxyprogesterone-acetate, followed by intramuscular (i) betamethasone (0...
2018: Neonatology
https://www.readbyqxmd.com/read/29629802/anastomotic-leaks-after-small-and-large-bowel-surgery-diagnostic-performance-of-ct-and-the-importance-of-intraluminal-contrast-administration
#16
Karim Bahadurali Samji, Ania Zofia Kielar, Michael Connolly, Najla Fasih, Geoffrey Doherty, Andrew Chung, Etienne Hache
OBJECTIVE: The objective of our study was to evaluate the diagnostic performance of CT in the identification of anastomotic leaks. MATERIALS AND METHODS: This was a study of patients who underwent bowel surgery and a subsequent postoperative CT examination performed specifically for investigating for an anastomotic leak. The study group included patients with surgically confirmed anastomotic leaks (n = 59), and the control group included patients without anastomotic leaks (n = 48) confirmed by either repeat surgery or uneventful clinical follow-up for at least 6 months...
June 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29621258/diva-metabolomics-differentiating-vaccination-status-following-viral-challenge-using-metabolomic-profiles
#17
Darren W Gray, Michael D Welsh, Fawad Mansoor, Simon Doherty, Olivier P Chevallier, Christopher T Elliott, Mark H Mooney
Bovine Respiratory Disease (BRD) is a major source of economic loss within the agricultural industry. Vaccination against BRD-associated viruses does not offer complete immune protection and vaccine failure animals present potential routes for disease spread. Serological differentiation of infected from vaccinated animals (DIVA) is possible using antigen-deleted vaccines, but during virus outbreaks DIVA responses are masked by wild-type virus preventing accurate serodiagnosis. Previous work by the authors has established the potential for metabolomic profiling to reveal metabolites associated with systemic immune responses to vaccination...
2018: PloS One
https://www.readbyqxmd.com/read/29609209/unmet-needs-and-the-path-forward-in-joint-disease-associated-with-calcium-pyrophosphate-crystal-deposition
#18
REVIEW
Abhishek Abhishek, Tuhina Neogi, Hyon Choi, Michael Doherty, Ann K Rosenthal, Robert Terkeltaub
Calcium pyrophosphate (CPP) crystal deposition (CPPD) is prevalent, and can be associated with synovitis and joint damage. The older-aged population predominantly affected by CPPD is growing rapidly. Since shortfalls exist in many aspects of CPPD, we conducted an anonymous survey of CPPD unmet needs, prioritized by experts from the Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN). We provide our perspectives on the survey results, and propose several CPPD basic and clinical translational research pathways...
April 2, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29599121/-what-s-my-risk-of-sustaining-an-acl-injury-while-playing-football-soccer-a-systematic-review-with-meta-analysis
#19
REVIEW
Alicia M Montalvo, Daniel K Schneider, Paula L Silva, Laura Yut, Kate E Webster, Michael A Riley, Adam W Kiefer, Jennifer L Doherty-Restrepo, Gregory D Myer
OBJECTIVE: To estimate the incidence proportion (IP) and incidence rate (IR) of ACL injury in football players. DESIGN: Systematic review with meta-analysis. DATA SOURCES: PubMed, CINAHL and SPORTDiscus electronic databases were searched from inception to 20 January 2017. ELIGIBILITY CRITERIA FOR SELECTING STUDY: Studies that reported the total number of participants/population by sex, total number of ACL injuries by sex and total person-time by sex were included...
March 29, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29533129/safety-study-of-live-oral-human-rotavirus-vaccine-a-cohort-study-in-united-states-health-insurance-plans
#20
Veena Hoffman, Remon Abu-Elyazeed, Cheryl Enger, Daina B Esposito, Michael C Doherty, Scott C Quinlan, Kathleen Skerry, Crystal N Holick, Peter Basile, Leonard R Friedland, Nicolas Praet, Stéphanie Wéry, Corinne Willame, David D Dore, Dominique Rosillon
As part of a regulatory commitment for post-licensure safety monitoring of live, oral human rotavirus vaccine (RV1), this study compared the incidence rates (IR) of intussusception, acute lower respiratory tract infection (LRTI) hospitalization, Kawasaki disease, convulsion, and mortality in RV1 recipients versus inactivated poliovirus vaccine (IPV) recipients in concurrent (cIPV) and recent historical (hIPV) comparison cohorts. Vaccine recipients were identified in 2 claims databases from August 2008 - June 2013 (RV1 and cIPV) and January 2004 - July 2008 (hIPV)...
March 13, 2018: Human Vaccines & Immunotherapeutics
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