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Michael Doherty

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https://www.readbyqxmd.com/read/29220880/development-of-a-new-biochip-array-for-apoe4-classification-from-plasma-samples-using-immunoassay-based-methods
#1
Sigrun Badrnya, Tara Doherty, Ciaran Richardson, Robert I McConnell, John V Lamont, Michael Veitinger, Stephen P FitzGerald, Maria Zellner, Ellen Umlauf
BACKGROUND: Apolipoprotein E (APOE) is a key player in lipid transport and metabolism and exists in three common isoforms: APOE2, APOE3 and APOE4. The presence of the E4 allelic variant is recognized as a major genetic risk factor for dementia and other chronic (neuro)degenerative diseases. The availability of a validated assay for rapid and reliable APOE4 classification is therefore advantageous. METHODS: Biochip array technology (BAT) was successfully applied to identify directly the APOE4 status from plasma within 3 h, through simultaneous immunoassay-based detection of both specific APOE4 and total APOE levels...
December 7, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29208732/the-next-generation-of-training-for-arabidopsis-researchers-bioinformatics-and-quantitative-biology
#2
Joanna Friesner, Sarah M Assmann, Ruth Bastow, Julia Bailey-Serres, Jim Beynon, Volker Brendel, C Robin Buell, Alexander Bucksch, Wolfgang Busch, Taku Demura, Jose R Dinneny, Colleen J Doherty, Andrea L Eveland, Pascal Falter-Braun, Malia A Gehan, Michael Gonzales, Erich Grotewold, Rodrigo Gutierrez, Ute Kramer, Gabriel Krouk, Shisong Ma, R J Cody Markelz, Molly Megraw, Blake C Meyers, James A H Murray, Nicholas J Provart, Sue Rhee, Roger Smith, Edgar P Spalding, Crispin Taylor, Tracy K Teal, Keiko U Torii, Chris Town, Matthew Vaughn, Richard Vierstra, Doreen Ware, Olivia Wilkins, Cranos Williams, Siobhan M Brady
No abstract text is available yet for this article.
December 2017: Plant Physiology
https://www.readbyqxmd.com/read/29201347/the-creation-and-evaluation-of-a-model-to-simulate-the-probability-of-conception-in-seasonal-calving-pasture-based-dairy-heifers
#3
Caroline Fenlon, Luke O'Grady, Stephen Butler, Michael L Doherty, John Dunnion
Background: Herd fertility in pasture-based dairy farms is a key driver of farm economics. Models for predicting nulliparous reproductive outcomes are rare, but age, genetics, weight, and BCS have been identified as factors influencing heifer conception. The aim of this study was to create a simulation model of heifer conception to service with thorough evaluation. Methods: Artificial Insemination service records from two research herds and ten commercial herds were provided to build and evaluate the models...
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/29198909/hiv-1-drug-resistance-before-initiation-or-re-initiation-of-first-line-antiretroviral-therapy-in-low-income-and-middle-income-countries-a-systematic-review-and-meta-regression-analysis
#4
Ravindra K Gupta, John Gregson, Neil Parkin, Hiwot Haile-Selassie, Amilcar Tanuri, Liliana Andrade Forero, Pontiano Kaleebu, Christine Watera, Avelin Aghokeng, Nicholus Mutenda, Janet Dzangare, San Hone, Zaw Zaw Hang, Judith Garcia, Zully Garcia, Paola Marchorro, Enrique Beteta, Amalia Giron, Raph Hamers, Seth Inzaule, Lisa M Frenkel, Michael H Chung, Tulio de Oliveira, Deenan Pillay, Kogie Naidoo, Ayesha Kharsany, Ruthiran Kugathasan, Teresa Cutino, Gillian Hunt, Santiago Avila Rios, Meg Doherty, Michael R Jordan, Silvia Bertagnolio
BACKGROUND: Pretreatment drug resistance in people initiating or re-initiating antiretroviral therapy (ART) containing non-nucleoside reverse transcriptase inhibitors (NNRTIs) might compromise HIV control in low-income and middle-income countries (LMICs). We aimed to assess the scale of this problem and whether it is associated with the intiation or re-initiation of ART in people who have had previous exposure to antiretroviral drugs. METHODS: This study was a systematic review and meta-regression analysis...
November 30, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29198315/mimicking-the-effects-of-spaceflight-on-bone-combined-effects-of-disuse-and-chronic-low-dose-rate-radiation-exposure-on-bone-mass-in-mice
#5
Kanglun Yu, Alison H Doherty, Paula C Genik, Sara E Gookin, Danielle M Roteliuk, Samantha J Wojda, Zhi-Sheng Jiang, Meghan E McGee-Lawrence, Michael M Weil, Seth W Donahue
During spaceflight, crewmembers are subjected to biomechanical and biological challenges including microgravity and radiation. In the skeleton, spaceflight leads to bone loss, increasing the risk of fracture. Studies utilizing hindlimb suspension (HLS) as a ground-based model of spaceflight often neglect the concomitant effects of radiation exposure, and even when radiation is accounted for, it is often delivered at a high-dose rate over a very short period of time, which does not faithfully mimic spaceflight conditions...
November 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29198264/international-quality-improvement-initiatives
#6
Patricia A Hickey, Jean A Connor, Kotturathu M Cherian, Kathy Jenkins, Kaitlin Doherty, Haibo Zhang, Michael Gaies, Sara Pasquali, Sarah Tabbutt, James D St Louis, George E Sarris, Hiromi Kurosawa, Richard A Jonas, Nestor Sandoval, Christo I Tchervenkov, Jeffery P Jacobs, Giovanni Stellin, James K Kirklin, Rajnish Garg, David F Vener
Across the globe, the implementation of quality improvement science and collaborative learning has positively affected the care and outcomes for children born with CHD. These efforts have advanced the collective expertise and performance of inter-professional healthcare teams. In this review, we highlight selected quality improvement initiatives and strategies impacting the field of cardiovascular care and describe implications for future practice and research. The continued leveraging of technology, commitment to data transparency, focus on team-based practice, and recognition of cultural norms and preferences ensure the success of sustainable models of global collaboration...
December 2017: Cardiology in the Young
https://www.readbyqxmd.com/read/29190847/adverse-maternal-and-neonatal-outcomes-in-indicated-compared-with-spontaneous-preterm-birth-in-healthy-nulliparas-a-secondary-analysis-of-a-randomized-trial
#7
Alan T Tita, Lindsay Doherty, Jim M Roberts, Leslie Myatt, Kenneth J Leveno, Michael W Varner, Ronald J Wapner, John M Thorp, Brian M Mercer, Alan Peaceman, Susan M Ramin, Marshall W Carpenter, Jay Iams, Anthony Sciscione, Margaret Harper, Jorge E Tolosa, George R Saade, Yoram Sorokin
No abstract text is available yet for this article.
November 30, 2017: American Journal of Perinatology
https://www.readbyqxmd.com/read/29174084/cost-effectiveness-of-public-health-policy-options-in-the-presence-of-pretreatment-nnrti-drug-resistance-in-sub-saharan-africa-a-modelling-study
#8
Andrew N Phillips, Valentina Cambiano, Fumiyo Nakagawa, Paul Revill, Michael R Jordan, Timothy B Hallett, Meg Doherty, Andrea De Luca, Jens D Lundgren, Mutsa Mhangara, Tsitsi Apollo, John Mellors, Brooke Nichols, Urvi Parikh, Deenan Pillay, Tobias Rinke de Wit, Kim Sigaloff, Diane Havlir, Daniel R Kuritzkes, Anton Pozniak, David van de Vijver, Marco Vitoria, Mark A Wainberg, Elliot Raizes, Silvia Bertagnolio
BACKGROUND: There is concern over increasing prevalence of non-nucleoside reverse-transcriptase inhibitor (NNRTI) resistance in people initiating antiretroviral therapy (ART) in low-income and middle-income countries. We assessed the effectiveness and cost-effectiveness of alternative public health responses in countries in sub-Saharan Africa where the prevalence of pretreatment drug resistance to NNRTIs is high. METHODS: The HIV Synthesis Model is an individual-based simulation model of sexual HIV transmission, progression, and the effect of ART in adults, which is based on extensive published data sources and considers specific drugs and resistance mutations...
November 22, 2017: Lancet HIV
https://www.readbyqxmd.com/read/29127345/the-synthetic-neuroactive-steroid-sge-516-reduces-seizure-burden-and-improves-survival-in-a-dravet-syndrome-mouse-model
#9
Nicole A Hawkins, Michael Lewis, Rebecca S Hammond, James J Doherty, Jennifer A Kearney
Dravet syndrome is an infant-onset epileptic encephalopathy with multiple seizure types that are often refractory to conventional therapies. Treatment with standard benzodiazepines like clobazam, in combination with valproate and stiripentol, provides only modest seizure control. While benzodiazepines are a first-line therapy for Dravet syndrome, they are limited by their ability to only modulate synaptic receptors. Unlike benzodiazepines, neuroactive steroids potentiate a wider-range of GABAA receptors. The synthetic neuroactive steroid SGE-516 is a potent positive allosteric modulator of both synaptic and extrasynaptic GABAA receptors...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29110264/optimization-of-drug-prescription-and-medication-management-in-older-adults-with-cardiovascular-disease
#10
Nanette K Wenger, Caroline Lloyd Doherty, Jerry H Gurwitz, Glenn A Hirsch, Holly M Holmes, Matthew S Maurer, Michael D Murray
Cardiovascular disease increases incrementally with age and elderly patients concomitantly sustain multimorbidities, with resultant prescription of multiple medications. Despite conforming with disease-specific cardiovascular clinical practice guidelines, this polypharmacy predisposes many elderly individuals with cardiovascular disease to adverse drug events and non-adherence. Patient-centered care requires that the clinician explore with each patient his or her goals of care and that this shared decision-making constitutes the basis for optimization of medication management...
November 6, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29101102/prevalence-of-knee-pain-radiographic-osteoarthritis-and-arthroplasty-in-retired-professional-footballers-compared-with-men-in-the-general-population-a-cross-sectional-study
#11
Gwen Sascha Fernandes, Sanjay Mukund Parekh, Jonathan Moses, Colin Fuller, Brigitte Scammell, Mark Edward Batt, Weiya Zhang, Michael Doherty
OBJECTIVES: To determine the prevalence of knee pain, radiographic knee osteoarthritis (RKOA), total knee replacement (TKR) and associated risk factors in male ex-professional footballers compared with men in the general population (comparison group). METHODS: 1207 male ex-footballers and 4085 men in the general population in the UK were assessed by postal questionnaire. Current knee pain was defined as pain in or around the knees on most days of the previous month...
November 3, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29094006/neuropathic-pain-like-symptoms-and-pre-surgery-radiographic-severity-contribute-to-patient-satisfaction-4-8-years-post-total-joint-replacement
#12
Sophie C Warner, Helen Richardson, Wendy Jenkins, Thomas Kurien, Michael Doherty, Ana M Valdes
AIM: To investigate a comprehensive range of factors that contribute to long-term patient satisfaction post-total joint replacement (TJR) in people who had undergone knee or hip replacement for osteoarthritis. METHODS: Participants (n = 1151) were recruited from Nottinghamshire post-total hip or knee replacement. Questionnaire assessment included medication use, the pain-DETECT questionnaire (PDQ) to assess neuropathic pain-like symptoms (NP) and TJR satisfaction measured on average 4...
October 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/29066081/acc-aats-aha-ase-asnc-hrs-scai-scct-scmr-sts-2017-appropriate-use-criteria-for-multimodality-imaging-in-valvular%C3%A2-heart-disease-a-report-of-the-american-college-of-cardiology-appropriate-use-criteria-task-force-american-association-for-thoracic-surgery-american
#13
John U Doherty, Smadar Kort, Roxana Mehran, Paul Schoenhagen, Prem Soman, Greg J Dehmer, John U Doherty, Paul Schoenhagen, Zahid Amin, Thomas M Bashore, Andrew Boyle, Dennis A Calnon, Blase Carabello, Manuel D Cerqueira, John Conte, Milind Desai, Daniel Edmundowicz, Victor A Ferrari, Brian Ghoshhajra, Praveen Mehrotra, Saman Nazarian, T Brett Reece, Balaji Tamarappoo, Wendy S Tzou, John B Wong, John U Doherty, Gregory J Dehmer, Steven R Bailey, Nicole M Bhave, Alan S Brown, Stacie L Daugherty, Larry S Dean, Milind Y Desai, Claire S Duvernoy, Linda D Gillam, Robert C Hendel, Christopher M Kramer, Bruce D Lindsay, Warren J Manning, Praveen Mehrotra, Manesh R Patel, Ritu Sachdeva, L Samuel Wann, David E Winchester, Michael J Wolk, Joseph M Allen
This document is 1 of 2 companion appropriate use criteria (AUC) documents developed by the American College of Cardiology, American Association for Thoracic Surgery, American Heart Association, American Society of Echocardiography, American Society of Nuclear Cardiology, Heart Rhythm Society, Society for Cardiovascular Angiography and Interventions, Society of Cardiovascular Computed Tomography, Society for Cardiovascular Magnetic Resonance, and Society of Thoracic Surgeons. This document addresses the evaluation and use of multimodality imaging in the diagnosis and management of valvular heart disease, whereas the second, companion document addresses this topic with regard to structural heart disease...
October 20, 2017: Journal of the American Society of Echocardiography
https://www.readbyqxmd.com/read/29040686/the-world-health-organization-s-response-to-emerging-human-immunodeficiency-virus-drug-resistance-and-a-call-for-global-action
#14
Silvia Bertagnolio, Rachel L Beanland, Michael R Jordan, Meg Doherty, And Gottfried Hirnschall
The global community, including the World Health Organization (WHO), has committed to ending the AIDS epidemic and to ensuring that 90% of people living with human immunodeficiency virus (HIV) are diagnosed, 90% start treatment, and 90% achieve and maintain virological suppression. The emergence of HIV drug resistance (HIVDR) as antiretroviral treatment programs expand could preclude the 90-90-90 targets adopted by the United Nations General Assembly at the High-Level Meeting on Ending AIDS from being achieved...
October 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29023487/triggers-of-acute-attacks-of-gout-does-age-of-gout-onset-matter-a-primary-care-based-cross-sectional-study
#15
Abhishek Abhishek, Ana M Valdes, Wendy Jenkins, Weiya Zhang, Michael Doherty
OBJECTIVES: To determine the proportion of people with gout who self-report triggers of acute attacks; identify the commonly reported triggers, and examine the disease and demographic features associated with self-reporting any trigger(s) of acute attacks of gout. METHODS: Individuals with gout were asked to fill a questionnaire enquiring about triggers that precipitated their acute gout attacks. Binary logistic regression was used to compute odds ratio (OR) and 95% confidence intervals (CI) to examine the association between having ≥1 self-reported trigger of acute gout and disease and demographic risk factors and to adjust for covariates...
2017: PloS One
https://www.readbyqxmd.com/read/28968809/the-worldwide-incidence-and-prevalence-of-systemic-lupus-erythematosus-a-systematic-review-of-epidemiological-studies
#16
REVIEW
Frances Rees, Michael Doherty, Matthew J Grainge, Peter Lanyon, Weiya Zhang
Objectives: The aim was to review the worldwide incidence and prevalence of SLE and variation with age, sex, ethnicity and time. Methods: A systematic search of MEDLINE and EMBASE search engines was carried out using Medical Subject Headings and keyword search terms for Systemic Lupus Erythematosus combined with incidence, prevalence and epidemiology in August 2013 and updated in September 2016. Author, journal, year of publication, country, region, case-finding method, study period, number of incident or prevalent cases, incidence (per 100 000 person-years) or prevalence (per 100 000 persons) and age, sex or ethnic group-specific incidence or prevalence were collected...
November 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28964826/randomized-four-arm-dose-response-clinical-trial-to-optimize-resistance-exercise-training-for-older-adults-with-age-related-muscle-atrophy
#17
Michael J Stec, Anna Thalacker-Mercer, David L Mayhew, Neil A Kelly, S Craig Tuggle, Edward K Merritt, Cynthia J Brown, Samuel T Windham, Louis J Dell'Italia, C Scott Bickel, Brandon M Roberts, Kristina M Vaughn, Irina Isakova-Donahue, Gina M Many, Marcas M Bamman
PURPOSE: The myriad consequences of age-related muscle atrophy include reduced muscular strength, power, and mobility; increased risk of falls, disability, and metabolic disease; and compromised immune function. At its root, aging muscle atrophy results from a loss of myofibers and atrophy of the remaining type II myofibers. The purpose of this trial (NCT02442479) was to titrate the dose of resistance training (RT) in older adults in an effort to maximize muscle regrowth and gains in muscle function...
December 1, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28941818/a-comparison-of-4-predictive-models-of-calving-assistance-and-difficulty-in-dairy-heifers-and-cows
#18
Caroline Fenlon, Luke O'Grady, John F Mee, Stephen T Butler, Michael L Doherty, John Dunnion
The aim of this study was to build and compare predictive models of calving difficulty in dairy heifers and cows for the purpose of decision support and simulation modeling. Models to predict 3 levels of calving difficulty (unassisted, slight assistance, and considerable or veterinary assistance) were created using 4 machine learning techniques: multinomial regression, decision trees, random forests, and neural networks. The data used were sourced from 2,076 calving records in 10 Irish dairy herds. In total, 19...
September 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28916715/response-to-different-glucosamine-sulfate-products-generate-different-outcomes-on-osteoarthritis-symptoms-by-reginster-et-al
#19
Jos Runhaar, Rianne M Rozendaal, Marienke van Middelkoop, Hans J W Bijlsma, Michael Doherty, Krysia S Dziedzic, L Stefan Lohmander, Timothy McAlindon, Weiya Zhang, Sita Bierma Zeinstra
No abstract text is available yet for this article.
September 15, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28888596/relative-importance-of-herd-level-risk-factors-for-probability-of-infection-with-paratuberculosis-in-irish-dairy-herds
#20
Conor G McAloon, Michael L Doherty, Paul Whyte, Simon J More, Luke O'Grady, Lorna Citer, Martin J Green
Control of paratuberculosis is challenging due to the relatively poor performance of diagnostic tests, a prolonged incubation period, and protracted environmental survival. Prioritization of herd-level interventions is not possible because putative risk factors are often not supported by risk factor studies. The objective for this study was to investigate the relative importance of risk factors for an increased probability of herd paratuberculosis infection. Risk assessment data, comprehensive animal purchase history, and diagnostic test data were available for 936 Irish dairy herds...
November 2017: Journal of Dairy Science
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