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Michael Doherty

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https://www.readbyqxmd.com/read/29040686/the-world-health-organization-s-response-to-emerging-human-immunodeficiency-virus-drug-resistance-and-a-call-for-global-action
#1
Silvia Bertagnolio, Rachel L Beanland, Michael R Jordan, Meg Doherty, And Gottfried Hirnschall
The global community, including the World Health Organization (WHO), has committed to ending the AIDS epidemic and to ensuring that 90% of people living with human immunodeficiency virus (HIV) are diagnosed, 90% start treatment, and 90% achieve and maintain virological suppression. The emergence of HIV drug resistance (HIVDR) as antiretroviral treatment programs expand could preclude the 90-90-90 targets adopted by the United Nations General Assembly at the High-Level Meeting on Ending AIDS from being achieved...
October 13, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29023487/triggers-of-acute-attacks-of-gout-does-age-of-gout-onset-matter-a-primary-care-based-cross-sectional-study
#2
Abhishek Abhishek, Ana M Valdes, Wendy Jenkins, Weiya Zhang, Michael Doherty
OBJECTIVES: To determine the proportion of people with gout who self-report triggers of acute attacks; identify the commonly reported triggers, and examine the disease and demographic features associated with self-reporting any trigger(s) of acute attacks of gout. METHODS: Individuals with gout were asked to fill a questionnaire enquiring about triggers that precipitated their acute gout attacks. Binary logistic regression was used to compute odds ratio (OR) and 95% confidence intervals (CI) to examine the association between having ≥1 self-reported trigger of acute gout and disease and demographic risk factors and to adjust for covariates...
2017: PloS One
https://www.readbyqxmd.com/read/28968809/the-worldwide-incidence-and-prevalence-of-systemic-lupus-erythematosus-a-systematic-review-of-epidemiological-studies
#3
Frances Rees, Michael Doherty, Matthew J Grainge, Peter Lanyon, Weiya Zhang
Objectives: The aim was to review the worldwide incidence and prevalence of SLE and variation with age, sex, ethnicity and time. Methods: A systematic search of MEDLINE and EMBASE search engines was carried out using Medical Subject Headings and keyword search terms for Systemic Lupus Erythematosus combined with incidence, prevalence and epidemiology in August 2013 and updated in September 2016. Author, journal, year of publication, country, region, case-finding method, study period, number of incident or prevalent cases, incidence (per 100 000 person-years) or prevalence (per 100 000 persons) and age, sex or ethnic group-specific incidence or prevalence were collected...
August 9, 2017: Rheumatology
https://www.readbyqxmd.com/read/28964826/randomized-four-arm-dose-response-clinical-trial-to-optimize-resistance-exercise-training-for-older-adults-with-age-related-muscle-atrophy
#4
Michael J Stec, Anna Thalacker-Mercer, David L Mayhew, Neil A Kelly, S Craig Tuggle, Edward K Merritt, Cynthia J Brown, Samuel T Windham, Louis J Dell'Italia, C Scott Bickel, Brandon M Roberts, Kristina M Vaughn, Irina Isakova-Donahue, Gina M Many, Marcas M Bamman
PURPOSE: The myriad consequences of age-related muscle atrophy include reduced muscular strength, power, and mobility; increased risk of falls, disability, and metabolic disease; and compromised immune function. At its root, aging muscle atrophy results from a loss of myofibers and atrophy of the remaining type II myofibers. The purpose of this trial (NCT02442479) was to titrate the dose of resistance training (RT) in older adults in an effort to maximize muscle regrowth and gains in muscle function...
September 28, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28941818/a-comparison-of-4-predictive-models-of-calving-assistance-and-difficulty-in-dairy-heifers-and-cows
#5
Caroline Fenlon, Luke O'Grady, John F Mee, Stephen T Butler, Michael L Doherty, John Dunnion
The aim of this study was to build and compare predictive models of calving difficulty in dairy heifers and cows for the purpose of decision support and simulation modeling. Models to predict 3 levels of calving difficulty (unassisted, slight assistance, and considerable or veterinary assistance) were created using 4 machine learning techniques: multinomial regression, decision trees, random forests, and neural networks. The data used were sourced from 2,076 calving records in 10 Irish dairy herds. In total, 19...
September 20, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28916715/response-to-different-glucosamine-sulfate-products-generate-different-outcomes-on-osteoarthritis-symptoms-by-reginster-et-al
#6
Jos Runhaar, Rianne M Rozendaal, Marienke van Middelkoop, Hans J W Bijlsma, Michael Doherty, Krysia S Dziedzic, L Stefan Lohmander, Timothy McAlindon, Weiya Zhang, Sita Bierma Zeinstra
No abstract text is available yet for this article.
September 15, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28888596/relative-importance-of-herd-level-risk-factors-for-probability-of-infection-with-paratuberculosis-in-irish-dairy-herds
#7
Conor G McAloon, Michael L Doherty, Paul Whyte, Simon J More, Luke O'Grady, Lorna Citer, Martin J Green
Control of paratuberculosis is challenging due to the relatively poor performance of diagnostic tests, a prolonged incubation period, and protracted environmental survival. Prioritization of herd-level interventions is not possible because putative risk factors are often not supported by risk factor studies. The objective for this study was to investigate the relative importance of risk factors for an increased probability of herd paratuberculosis infection. Risk assessment data, comprehensive animal purchase history, and diagnostic test data were available for 936 Irish dairy herds...
November 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28883634/association-of-the-resolvin-precursor-17-hdha-but-not-d-or-e-series-resolvins-with-heat-pain-sensitivity-and-osteoarthritis-pain-in-humans
#8
Ana M Valdes, Srinivasarao Ravipati, Cristina Menni, Abhishek Abhishek, Sarah Metrustry, Juliette Harris, Ayrun Nessa, Frances M K Williams, Tim D Spector, Michael Doherty, Victoria Chapman, David A Barrett
Resolvins are omega-3 fatty acid derived potent bioactive lipids that resolve inflammation and modulate transient receptor potential channels. Exogenous administration of the resolvin precursor 17-HDHA shows a strong analgesic effect in animal models of osteoarthritis and acute inflammatory pain, but has not been studied in humans. Our aim was to assess the role of 17-HDHA and resolvins in heat pain sensitivity and in osteoarthritis pain in humans. Resolvins D1, D2, D3, D5, E1 and 17-HDHA, were measured by liquid chromatography-mass spectrometry and tested for association with heat pain thresholds in 250 healthy volunteers who had undergone quantitative sensory testing...
September 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28882829/childhood-cognitive-development-in-22q11-2-deletion-syndrome-case-control-study
#9
Samuel J R A Chawner, Joanne L Doherty, Hayley Moss, Maria Niarchou, James T R Walters, Michael J Owen, Marianne B M van den Bree
Background22q11.2 deletion syndrome (22q11.2DS) is associated with a high risk of childhood as well as adult psychiatric disorders, in particular schizophrenia. Childhood cognitive deterioration in 22q11.2DS has previously been reported, but only in studies lacking a control sample.AimsTo compare cognitive trajectories in children with 22q11.2DS and unaffected control siblings.MethodA longitudinal study of neurocognitive functioning (IQ, executive function, processing speed and attention) was conducted in children with 22q11...
October 2017: British Journal of Psychiatry: the Journal of Mental Science
https://www.readbyqxmd.com/read/28838393/prognostic-and-predictive-effects-of-tp53-co-mutation-in-patients-with-egfr-mutated-non-small-cell-lung-cancer-nsclc
#10
Catherine Labbé, Michael Cabanero, Grzegorz J Korpanty, Pascale Tomasini, Mark K Doherty, Céline Mascaux, Kevin Jao, Bethany Pitcher, Rick Wang, Melania Pintilie, Natasha B Leighl, Ronald Feld, Geoffrey Liu, Penelope Ann Bradbury, Suzanne Kamel-Reid, Ming-Sound Tsao, Frances A Shepherd
INTRODUCTION: TP53 mutations are common in non-small cell lung cancer (NSCLC) and have been reported as prognostic of poor outcome. The impact of TP53 co-mutations in epidermal growth factor receptor (EGFR)-mutated NSCLC is unclear. MATERIALS AND METHODS: Tissue from 105 patients with EGFR-mutated NSCLC at Princess Margaret Cancer Centre was analyzed by next-generation or Sanger sequencing to determine TP53 mutational status. Associations between TP53 status and baseline patient and tumor characteristics, treatments and outcomes (relapse-free survival [RFS] after surgical resection, overall survival [OS], overall response rate [ORR] and progression-free survival [PFS] on EGFR tyrosine kinase inhibitors [TKIs]), were investigated...
September 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28830942/diabetes-exacerbates-infection-via-hyperinflammation-by-signaling-through-tlr4-and-rage
#11
Travis B Nielsen, Paul Pantapalangkoor, Jun Yan, Brian M Luna, Ken Dekitani, Kevin Bruhn, Brandon Tan, Justin Junus, Robert A Bonomo, Ann Marie Schmidt, Michael Everson, Frederick Duncanson, Terence M Doherty, Lin Lin, Brad Spellberg
For more than a century, diabetic patients have been considered immunosuppressed due to defects in phagocytosis and microbial killing. We confirmed that diabetic mice were hypersusceptible to bacteremia caused by Gram-negative bacteria (GNB), dying at inocula nonlethal to nondiabetic mice. Contrary to the pervasive paradigm that diabetes impedes phagocytic function, the bacterial burden was no greater in diabetic mice despite excess mortality. However, diabetic mice did exhibit dramatically increased levels of proinflammatory cytokines in response to GNB infections, and immunosuppressing these cytokines with dexamethasone restored their resistance to infection, both of which are consistent with excess inflammation...
August 22, 2017: MBio
https://www.readbyqxmd.com/read/28799350/critical-length-of-a-one-dimensional-nucleus
#12
Mark N Joswiak, Michael F Doherty, Baron Peters
One-dimensional (1D) nucleation is important in crystal growth, amyloid fibril formation, and supramolecular polymerization. The nucleation rate can be readily calculated, but there is no consensus on the critical length. In this work, we employ a splitting probability to derive an analytical expression for the critical length, which corresponds to a 50% survival probability. For a 1D nucleus on a crystal step, this critical length depends on the supersaturation (driving force) and is nearly independent of the kink (surface) energy...
December 7, 2016: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28797283/incident-gout-and-erectile-dysfunction-is-hyperuricaemia-the-elephant-in-the-room
#13
EDITORIAL
Abhishek Abhishek, Michael Doherty
The first prospective population-based study to examine risk of erectile dysfunction in men with gout in the western world has been published. It reports that following their first diagnosis of gout, men have a 31% higher risk of erectile dysfunction than matched controls, although the absolute increase in risk is small. Of interest, the incidence of erectile dysfunction reported in this study is tenfold higher than those reported in nation-wide cohort studies from Taiwan. There is a need for further prospective cohort studies to examine the possible mechanistic association between gout, hyperuricaemia and erectile dysfunction...
August 10, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28794514/discordant-american-college-of-physicians-and-international-rheumatology-guidelines-for-gout-management-consensus-statement-of-the-gout-hyperuricemia-and-crystal-associated-disease-network-g-can
#14
REVIEW
Nicola Dalbeth, Thomas Bardin, Michael Doherty, Frédéric Lioté, Pascal Richette, Kenneth G Saag, Alexander K So, Lisa K Stamp, Hyon K Choi, Robert Terkeltaub
In November 2016, the American College of Physicians (ACP) published a clinical practice guideline on the management of acute and recurrent gout. This guideline differs substantially from the latest guidelines generated by the American College of Rheumatology (ACR), European League Against Rheumatism (EULAR) and 3e (Evidence, Expertise, Exchange) Initiative, despite reviewing largely the same body of evidence. The Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN) convened an expert panel to review the methodology and conclusions of these four sets of guidelines and examine possible reasons for discordance between them...
September 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28777934/mutations-in-trappc12-manifest-in-progressive-childhood-encephalopathy-and-golgi-dysfunction
#15
Miroslav P Milev, Megan E Grout, Djenann Saint-Dic, Yong-Han Hank Cheng, Ian A Glass, Christopher J Hale, David S Hanna, Michael O Dorschner, Keshika Prematilake, Avraham Shaag, Orly Elpeleg, Michael Sacher, Dan Doherty, Simon Edvardson
Progressive childhood encephalopathy is an etiologically heterogeneous condition characterized by progressive central nervous system dysfunction in association with a broad range of morbidity and mortality. The causes of encephalopathy can be either non-genetic or genetic. Identifying the genetic causes and dissecting the underlying mechanisms are critical to understanding brain development and improving treatments. Here, we report that variants in TRAPPC12 result in progressive childhood encephalopathy. Three individuals from two unrelated families have either a homozygous deleterious variant (c...
August 3, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28776014/new-tricks-of-the-trade-for-crystal-structure-refinement
#16
Jinjin Li, Yuriy A Abramov, Michael F Doherty
Accurate crystal structures and their experimental uncertainties, determined by X-ray diffraction/neutron diffraction techniques, are vital for crystal engineering studies, such as polymorph stability and crystal morphology calculations. Because of differences in crystal growth and data measurement conditions, crystallographic databases often contain multiple entries of varying quality of the same compound. The choice of the most reliable and best quality crystal structure from many very similar structures remains an unresolved problem, especially for nonexperts...
July 26, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28759580/knowledge-attitudes-and-practices-towards-yaws-and-yaws-like-skin-disease-in-ghana
#17
Michael Marks, Cynthia Kwakye-Maclean, Rachel Doherty, Paul Adwere, Abdul Aziz Abdulai, Fredrick Duah, Sally-Ann Ohene, Oriol Mitja, Blanche Oguti, Anthony W Solomon, David C W Mabey, Yaw Adu-Sarkodie, Kingsley Asiedu, Mercy M Ackumey
INTRODUCTION: Yaws is endemic in Ghana. The World Health Organization (WHO) has launched a new global eradication campaign based on total community mass treatment with azithromycin. Achieving high coverage of mass treatment will be fundamental to the success of this new strategy; coverage is dependent, in part, on appropriate community mobilisation. An understanding of community knowledge, attitudes and practices related to yaws in Ghana and other endemic countries will be vital in designing effective community engagement strategies...
July 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28754801/subgroup-analyses-of-the-effectiveness-of-oral-glucosamine-for-knee-and-hip-osteoarthritis-a-systematic-review-and-individual-patient-data-meta-analysis-from-the-oa-trial-bank
#18
Jos Runhaar, Rianne M Rozendaal, Marienke van Middelkoop, Hans J W Bijlsma, Michael Doherty, Krysia S Dziedzic, L Stefan Lohmander, Timothy McAlindon, Weiya Zhang, Sita Bierma Zeinstra
OBJECTIVE: To evaluate the effectiveness of oral glucosamine in subgroups of people with hip or knee osteoarthritis (OA) based on baseline pain severity, body mass index (BMI), sex, structural abnormalities and presence of inflammation using individual patient data. METHODS: After a systematic search of the literature and clinical trial registries, all randomised controlled trials (RCTs) evaluating the effect of any oral glucosamine substance in patients with clinically or radiographically defined hip or knee OA were contacted...
July 28, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28753313/neuroactive-steroids-2-3%C3%AE-hydroxy-3%C3%AE-methyl-21-4-cyano-1h-pyrazol-1-yl-19-nor-5%C3%AE-pregnan-20-one-sage-217-a-clinical-next-generation-neuroactive-steroid-positive-allosteric-modulator-of-the-%C3%AE-aminobutyric-acid-a-receptor
#19
Gabriel Martinez Botella, Francesco G Salituro, Boyd L Harrison, Richard T Beresis, Zhu Bai, Maria-Jesus Blanco, Gabriel M Belfort, Jing Dai, Carlos M Loya, Michael A Ackley, Alison L Althaus, Scott J Grossman, Ethan Hoffmann, James J Doherty, Albert J Robichaud
Certain classes of neuroactive steroids (NASs) are positive allosteric modulators (PAM) of synaptic and extrasynaptic GABAA receptors. Herein, we report new SAR insights in a series of 5β-nor-19-pregnan-20-one analogues bearing substituted pyrazoles and triazoles at C-21, culminating in the discovery of 3α-hydroxy-3β-methyl-21-(4-cyano-1H-pyrazol-1'-yl)-19-nor-5β-pregnan-20-one (SAGE-217, 3), a potent GABAA receptor modulator at both synaptic and extrasynaptic receptor subtypes, with excellent oral DMPK properties...
September 28, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28736278/efficacy-paradox-and-proportional-contextual-effect-pce
#20
Weiya Zhang, Michael Doherty
The "efficacy paradox" is when the effect of a treatment tested in an RCT, or evidence-based guideline advice, differs markedly from treatment benefits observed in clinical practice. This arises because in RCT reporting and guideline development treatment efficacy is judged by the separation of the treatment group from the placebo group (the specific treatment effect) whereas in clinical practice it is the overall treatment effect, which includes both specific and contextual responses, that patients experience...
July 20, 2017: Clinical Immunology: the Official Journal of the Clinical Immunology Society
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