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Michael Doherty

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https://www.readbyqxmd.com/read/29669335/antenatal-corticosteroid-exposure-disrupts-myelination-in-the-auditory-nerve-of-preterm-sheep
#1
Judith Rittenschober-Böhm, Jennifer Rodger, Alan H Jobe, Suhas G Kallapur, Dorota A Doherty, Boris W Kramer, Matthew S Payne, Michael Archer, Christian Rittenschober, John P Newnham, Yuichiro Miura, Angelika Berger, Stephen G Matthews, Matthew W Kemp
BACKGROUND: Antenatal corticosteroids (ACS) improve preterm neonatal outcomes. However, uncertainty remains regarding the safety of ACS exposure for the developing fetus, particularly its neurosensory development. OBJECTIVES: We investigated the effect of single and multiple ACS exposures on auditory nerve development in an ovine model of pregnancy. METHODS: Ewes with a single fetus (gestational age [GA] 100 days) received an intramuscular injection of 150 mg medroxyprogesterone-acetate, followed by intramuscular (i) betamethasone (0...
April 17, 2018: Neonatology
https://www.readbyqxmd.com/read/29629802/anastomotic-leaks-after-small-and-large-bowel-surgery-diagnostic-performance-of-ct-and-the-importance-of-intraluminal-contrast-administration
#2
Karim Bahadurali Samji, Ania Zofia Kielar, Michael Connolly, Najla Fasih, Geoffrey Doherty, Andrew Chung, Etienne Hache
OBJECTIVE: The objective of our study was to evaluate the diagnostic performance of CT in the identification of anastomotic leaks. MATERIALS AND METHODS: This was a study of patients who underwent bowel surgery and a subsequent postoperative CT examination performed specifically for investigating for an anastomotic leak. The study group included patients with surgically confirmed anastomotic leaks (n = 59), and the control group included patients without anastomotic leaks (n = 48) confirmed by either repeat surgery or uneventful clinical follow-up for at least 6 months...
April 9, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29621258/diva-metabolomics-differentiating-vaccination-status-following-viral-challenge-using-metabolomic-profiles
#3
Darren W Gray, Michael D Welsh, Fawad Mansoor, Simon Doherty, Olivier P Chevallier, Christopher T Elliott, Mark H Mooney
Bovine Respiratory Disease (BRD) is a major source of economic loss within the agricultural industry. Vaccination against BRD-associated viruses does not offer complete immune protection and vaccine failure animals present potential routes for disease spread. Serological differentiation of infected from vaccinated animals (DIVA) is possible using antigen-deleted vaccines, but during virus outbreaks DIVA responses are masked by wild-type virus preventing accurate serodiagnosis. Previous work by the authors has established the potential for metabolomic profiling to reveal metabolites associated with systemic immune responses to vaccination...
2018: PloS One
https://www.readbyqxmd.com/read/29609209/unmet-needs-and-the-path-forward-in-joint-disease-associated-with-calcium-pyrophosphate-crystal-deposition
#4
REVIEW
Abhishek Abhishek, Tuhina Neogi, Hyon Choi, Michael Doherty, Ann K Rosenthal, Robert Terkeltaub
Calcium pyrophosphate (CPP) crystal deposition (CPPD) is prevalent, and can be associated with synovitis and joint damage. The older-aged population predominantly affected by CPPD is growing rapidly. Since shortfalls exist in many aspects of CPPD, we conducted an anonymous survey of CPPD unmet needs, prioritized by experts from the Gout, Hyperuricemia and Crystal-Associated Disease Network (G-CAN). We provide our perspectives on the survey results, and propose several CPPD basic and clinical translational research pathways...
April 2, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29599121/-what-s-my-risk-of-sustaining-an-acl-injury-while-playing-football-soccer-a-systematic-review-with-meta-analysis
#5
REVIEW
Alicia M Montalvo, Daniel K Schneider, Paula L Silva, Laura Yut, Kate E Webster, Michael A Riley, Adam W Kiefer, Jennifer L Doherty-Restrepo, Gregory D Myer
OBJECTIVE: To estimate the incidence proportion (IP) and incidence rate (IR) of ACL injury in football players. DESIGN: Systematic review with meta-analysis. DATA SOURCES: PubMed, CINAHL and SPORTDiscus electronic databases were searched from inception to 20 January 2017. ELIGIBILITY CRITERIA FOR SELECTING STUDY: Studies that reported the total number of participants/population by sex, total number of ACL injuries by sex and total person-time by sex were included...
March 29, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29533129/safety-study-of-live-oral-human-rotavirus-vaccine-a-cohort-study-in-united-states-health-insurance-plans
#6
Veena Hoffman, Remon Abu-Elyazeed, Cheryl Enger, Daina B Esposito, Michael C Doherty, Scott C Quinlan, Kathleen Skerry, Crystal N Holick, Peter Basile, Leonard R Friedland, Nicolas Praet, Stéphanie Wéry, Corinne Willame, David D Dore, Dominique Rosillon
As part of a regulatory commitment for post-licensure safety monitoring of live, oral human rotavirus vaccine (RV1), this study compared the incidence rates (IR) of intussusception, acute lower respiratory tract infection (LRTI) hospitalization, Kawasaki disease, convulsion, and mortality in RV1 recipients versus inactivated poliovirus vaccine (IPV) recipients in concurrent (cIPV) and recent historical (hIPV) comparison cohorts. Vaccine recipients were identified in 2 claims databases from August 2008 - June 2013 (RV1 and cIPV) and January 2004 - July 2008 (hIPV)...
March 13, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29525770/steps-towards-alcohol-misuse-prevention-programme-stampp-a-school-based-and-community-based-cluster-randomised-controlled-trial
#7
Michael McKay, Ashley Agus, Jonathan Cole, Paul Doherty, David Foxcroft, Séamus Harvey, Lynn Murphy, Andrew Percy, Harry Sumnall
OBJECTIVES: To assess the effectiveness of a combined classroom curriculum and parental intervention (the Steps Towards Alcohol Misuse Prevention Programme (STAMPP)), compared with alcohol education as normal (EAN), in reducing self-reported heavy episodic drinking (HED) and alcohol-related harms (ARHs) in adolescents. SETTING: 105 high schools in Northern Ireland (NI) and in Scotland. PARTICIPANTS: Schools were stratified by free school meal provision...
March 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29524100/-all-by-myself-interns-reports-of-their-experiences-taking-consent-in-irish-hospitals
#8
Roisin M Heaney, Michael Murray, Aine M Heaney, Eva M Doherty
BACKGROUND: Obtaining patient consent is a fundamental process in surgical practice and is integral in respecting and safeguarding patient autonomy. It has been reported that the task of consenting patients frequently lies with junior doctors, who have the least experience of the procedure. AIM: To examine the role of interns in the consent process in the Irish context as well as to identify their concerns. METHODS: A 12-point questionnaire, assessing interns' experience with surgical consent, was circulated to interns in three Irish university teaching hospitals based in different geographical locations...
March 9, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29504388/hiv-drug-resistance
#9
COMMENT
Silvia Bertagnolio, Michael R Jordan, Meg Doherty
No abstract text is available yet for this article.
March 1, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29484563/4d-ct-is-superior-to-ultrasound-and-sestamibi-for-localizing-recurrent-parathyroid-disease
#10
Moska Hamidi, Michael Sullivan, George Hunter, Leena Hamberg, Nancy L Cho, Atul A Gawande, Gerard M Doherty, Francis D Moore, Matthew A Nehs
BACKGROUND: Recurrent primary hyperparathyroidism (PHPT) presents a diagnostic challenge in localizing a hyperfunctioning gland. Although several imaging modalities are available for preoperative localization, 4D-CT is increasingly utilized for its ability to locate both smaller and previously unlocalized lesions. Currently, there is a paucity of data evaluating the utility of 4D-CT in the reoperative setting compared with ultrasound (US) and sestamibi. We aimed to determine the sensitivity of 4D-CT in localizing parathyroid adenomas in recurrent or persistent PHPT...
February 26, 2018: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29476014/positive-allosteric-modulation-as-a-potential-therapeutic-strategy-in-anti-nmda-receptor-encephalitis
#11
Natasha Warikoo, Samuel J Brunwasser, Ann Benz, Hong-Jin Shu, Steven M Paul, Michael Lewis, James Doherty, Michael Quick, Laura Piccio, Charles F Zorumski, Gregory S Day, Steven Mennerick
N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors important for synaptic plasticity, memory, and neuropsychiatric health. NMDAR hypofunction contributes to multiple disorders, including anti-NMDAR encephalitis (NMDARE), an autoimmune disease of the central nervous system associated with GluN1 antibody-mediated NMDAR internalization. Here we characterize the functional/pharmacological consequences of exposure to cerebrospinal fluid (CSF) from female human NMDARE patients on NMDAR function, and we characterize the effects of intervention with recently described positive allosteric modulators (PAMs) of NMDARs...
February 23, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29459986/hydroxychloroquine-effectiveness-in-reducing-symptoms-of-hand-osteoarthritis-a-randomized-trial
#12
Sarah R Kingsbury, Puvan Tharmanathan, Ada Keding, Sarah J Ronaldson, Andrew Grainger, Richard J Wakefield, Catherine Arundel, Fraser Birrell, Michael Doherty, Tonia Vincent, Fiona E Watt, Krysia Dziedzic, Terence W O'Neill, Nigel K Arden, David L Scott, John Dickson, Toby Garrood, Michael Green, Ajit Menon, Tom Sheeran, David Torgerson, Philip G Conaghan
Background: Synovitis is believed to play a role in producing symptoms in persons with hand osteoarthritis, but data on slow-acting anti-inflammatory treatments are sparse. Objective: To determine the effectiveness of hydroxychloroquine versus placebo as an analgesic treatment of hand osteoarthritis. Design: Randomized, double-blind, placebo-controlled clinical trial with 12-month follow-up. (ISRCTN registry number: ISRCTN91859104). Setting: 13 primary and secondary care centers in England...
February 20, 2018: Annals of Internal Medicine
https://www.readbyqxmd.com/read/29438225/traits-associated-with-central-pain-augmentation-in-the-knee-pain-in-the-community-kpic-cohort
#13
Kehinde Akin-Akinyosoye, Nadia Frowd, Laura Marshall, Joanne Stocks, Gwen Fernandes, Ana Valdes, Daniel F McWilliams, Weiya Zhang, Michael Doherty, Eamonn Ferguson, David A Walsh
This study aimed to identify self-report correlates of central pain augmentation in individuals with knee pain. A subset of participants (n=420) in the Knee Pain and related health In the Community (KPIC) baseline survey undertook pressure pain threshold (PPT) assessments. Items measuring specific traits related to central pain mechanisms were selected from the survey based on expert consensus, face validity, item association to underlying constructs measured by originating host questionnaires, adequate targeting and PPT correlations...
February 9, 2018: Pain
https://www.readbyqxmd.com/read/29436380/relative-efficacy-and-safety-of-topical-non-steroidal-anti-inflammatory-drugs-for-osteoarthritis-a-systematic-review-and-network-meta-analysis-of-randomised-controlled-trials-and-observational-studies
#14
REVIEW
Chao Zeng, Jie Wei, Monica S M Persson, Aliya Sarmanova, Michael Doherty, Dongxing Xie, YiLun Wang, Xiaoxiao Li, Jiatian Li, Huizhong Long, Guanghua Lei, Weiya Zhang
OBJECTIVES: To compare the efficacy and safety of topical non-steroidal anti-inflammatory drugs (NSAIDs), including salicylate, for the treatment of osteoarthritis (OA). METHODS: PubMed, Embase, Cochrane Library and Web of Science were searched from 1966 to January 2017. Randomised controlled trials (RCTs) comparing topical NSAIDs with placebo or each other in patients with OA and observational studies comparing topical NSAIDs with no treatment or each other irrespective of disease were included...
February 7, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29435177/prostate-selective-%C3%AE-antagonists-increase-fracture-risk-in-prostate-cancer-patients-with-and-without-a-history-of-androgen-deprivation-therapy-a-nationwide-population-based-study
#15
Wei-Heng Kao, Chang-Fu Kuo, I-Jun Chou, Lai-Chu See, Wen-Kuan Huang, Meng-Jiun Chiou, Weiya Zhang, Michael Doherty, Chun-Chieh Wang, Jun-Te Hsu, Hsien-Hsin Chen, Ji-Hong Hong
Introductions: Prostate-selective α antagonists are recommended for relief of lower urinary tract symptoms in prostate cancer patients despite uncertainty of fracture risk as an addition to androgen deprivation therapy (ADT). The purpose of this study is to estimate fracture risk associated with these medications in prostate cancer patients who did and did not receive ADT. Methods: The Taiwan National Health Insurance database was used to identify prostate cancer patients...
January 12, 2018: Oncotarget
https://www.readbyqxmd.com/read/29395023/is-there-a-role-for-ytrrium-90-in-the-treatment-of-unresectable-and-metastatic-intrahepatic-cholangiocarcinoma
#16
Tamer M Shaker, Chloe Chung, Manish K Varma, Michael G Doherty, Andrea M Wolf, Mathew H Chung, M Mura Assifi
BACKGROUND: Selective internal radiation therapy (SIRT) with Ytrrium-90 (Y-90) has been used to treat hepatic malignancies with success. This study focuses on the efficacy and safety of Y-90 in the treatment of unresectable and metastatic intrahepatic cholangiocarcinoma (ICC). METHODS: A single-institution retrospective case review was performed for patients with unresectable and metastatic ICC treated with Y-90 between 2006 and 2016. RESULTS: Seventeen patients with ICC underwent 21 Y-90 treatments...
January 30, 2018: American Journal of Surgery
https://www.readbyqxmd.com/read/29315623/tumor-necrosis-factor-family-member-light-acts-with-il-1%C3%AE-and-tgf-%C3%AE-to-promote-airway-remodeling-during-rhinovirus-infection
#17
A K Mehta, T Doherty, D Broide, M Croft
BACKGROUND: Rhinovirus (RV) can exacerbate allergen-driven asthma. However, it has been suggested that serial infections with RV may also lead to asthma-like features in childhood without prior allergen exposure. AIM: We sought to test the effects of RV infection in the absence of allergen challenge on lung tissue remodeling and to understand whether RV induced factors in common with allergen that promote remodeling. METHODS: We infected C57BL/6 mice multiple times with RV in the absence or presence of allergen to assess airway remodeling...
January 9, 2018: Allergy
https://www.readbyqxmd.com/read/29311331/ion-dissolution-mechanism-and-kinetics-at-kink-sites-on-nacl-surfaces
#18
Mark N Joswiak, Michael F Doherty, Baron Peters
Desolvation barriers are present for solute-solvent exchange events, such as ligand binding to an enzyme active site, during protein folding, and at battery electrodes. For solution-grown crystals, desolvation at kink sites can be the rate-limiting step for growth. However, desolvation and the associated kinetic barriers are poorly understood. In this work, we use rare-event simulation techniques to investigate attachment/detachment events at kink sites of a NaCl crystal in water. We elucidate the desolvation mechanism and present an optimized reaction coordinate, which involves one solute collective variable and one solvent collective variable...
January 23, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29290291/a-discussion-of-calibration-techniques-for-evaluating-binary-and-categorical-predictive-models
#19
REVIEW
Caroline Fenlon, Luke O'Grady, Michael L Doherty, John Dunnion
Modelling of binary and categorical events is a commonly used tool to simulate epidemiological processes in veterinary research. Logistic and multinomial regression, naïve Bayes, decision trees and support vector machines are popular data mining techniques used to predict the probabilities of events with two or more outcomes. Thorough evaluation of a predictive model is important to validate its ability for use in decision-support or broader simulation modelling. Measures of discrimination, such as sensitivity, specificity and receiver operating characteristics, are commonly used to evaluate how well the model can distinguish between the possible outcomes...
January 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29287118/serum-n-propeptide-of-collagen-iia-piianp-as-a-marker-of-radiographic-osteoarthritis-burden
#20
Hikmat N Daghestani, Joanne M Jordan, Jordan B Renner, Michael Doherty, A Gerry Wilson, Virginia B Kraus
OBJECTIVE: Cartilage homeostasis relies on a balance of catabolism and anabolism of cartilage matrix. Our goal was to evaluate the burden of radiographic osteoarthritis and serum levels of type IIA procollagen amino terminal propeptide (sPIIANP), a biomarker representing type II collagen synthesis, in osteoarthritis. METHODS: OA burden was quantified on the basis of radiographic features as total joint faces with an osteophyte, joint space narrowing, or in the spine, disc space narrowing...
2017: PloS One
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