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https://www.readbyqxmd.com/read/28476075/drugs-for-discoid-lupus-erythematosus
#1
REVIEW
Sue Jessop, David A Whitelaw, Matthew J Grainge, Prativa Jayasekera
BACKGROUND: Discoid lupus erythematosus (DLE) is a chronic form of cutaneous lupus, which can cause scarring. Many drugs have been used to treat this disease and some (such as thalidomide, cyclophosphamide and azathioprine) are potentially toxic. This is an update of a Cochrane Review first published in 2000, and previously updated in 2009. We wanted to update the review to assess whether any new information was available to treat DLE, as we were still unsure of the effectiveness of available drugs and how to select the most appropriate treatment for an individual with DLE...
May 5, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28251917/long-term-survival-in-paraneoplastic-lambert-eaton-myasthenic-syndrome
#2
Paul Maddison, Paul Gozzard, Matthew J Grainge, Bethan Lang
OBJECTIVE: To establish whether improved tumor survival in patients with Lambert-Eaton myasthenic syndrome (LEMS) and small-cell lung cancer (SCLC) was due to known prognostic risk factors or an effect of LEMS independently, perhaps as a result of circulating factors. METHODS: We undertook a prospective observational cohort study of patients with LEMS attending Nottingham University Hospitals, UK, or via the British Neurological Surveillance Unit. In parallel, patients with a new diagnosis of biopsy-proven SCLC were enrolled, examined for neurologic illness, and followed up until death or study end...
April 4, 2017: Neurology
https://www.readbyqxmd.com/read/28160009/familial-aggregation-of-rheumatoid-arthritis-and-co-aggregation-of-autoimmune-diseases-in-affected-families-a-nationwide-population-based-study
#3
Chang-Fu Kuo, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Kuang-Hui Yu, S W Steven Shaw, Shue-Fen Luo, Weiya Zhang, Michael Doherty
Objective.: The aim was to estimate familial relative risk (RR) for RA and other autoimmune diseases and the genetic contribution to RA phenotypic variance (heritability). Methods.: This study used the Taiwan National Health Insurance Research Database to identify all National Health Insurance registered beneficiaries (n = 23 658 577) in 2010; among them, 37 482 individuals had RA. We estimated familial RRs and 95% CIs of RA and other autoimmune diseases using marginal Cox proportional models and heritability of RA using a threshold liability model...
June 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28106922/recurrence-risk-of-venous-thromboembolism-and-hormone-use-in-women-from-england-a-cohort-study-using-clinical-practice-research-datalink
#4
Sylvia Kiconco, Alyshah Abdul Sultan, Matthew J Grainge
It is vital to identify people with low recurrence risk of venous thromboembolism (VTE) so as to protect them from dangers of prolonged anticoagulation therapy. Among women who develop VTE following hormone use, the evidence as to whether their risk of recurrence is low if they cease this therapy is conflicting. We investigated whether women whose initial VTE event was hormone-related have a lower risk of VTE recurrence than women whose initial event had no obvious cause (unprovoked). A cohort study utilising the Clinical Practice Research Datalink linked to Hospital Episode Statistics data from England was conducted...
April 2017: British Journal of Haematology
https://www.readbyqxmd.com/read/28102968/thoracic-ultrasound-recognition-of-competence-a-position-paper-of-the-thoracic-society-of-australia-and-new-zealand
#5
Jonathan P Williamson, Scott H Twaddell, Y C Gary Lee, Matthew Salamonsen, Mark Hew, David Fielding, Phan Nguyen, Daniel Steinfort, Peter Hopkins, Nicola Smith, Christopher Grainge
The ability to perform bedside thoracic ultrasound is increasingly recognized as an essential skill for thoracic clinicians, extending the clinical examination and aiding diagnostic and therapeutic procedures. Thoracic ultrasound reduces complications and increases success rates when used prior to thoracentesis or intercostal chest tube insertion. It is increasingly difficult to defend performing these procedures without real or near-real time image guidance. To assist thoracic physicians and others achieve and demonstrate thoracic ultrasound competence, the Interventional Pulmonology Special Interest Group (IP-SIG) of the Thoracic Society of Australia and New Zealand (TSANZ) has developed a new pathway with four components: (i) completion of an approved thoracic ultrasound theory and hands-on teaching course...
February 2017: Respirology: Official Journal of the Asian Pacific Society of Respirology
https://www.readbyqxmd.com/read/28064207/rheumatoid-arthritis-is-getting-less-frequent-results-of-a-nationwide-population-based-cohort-study
#6
Abhishek Abhishek, Michael Doherty, Chang-Fu Kuo, Christian D Mallen, Weiya Zhang, Matthew J Grainge
Objectives.: The objectives of this study were to examine changes in the incidence and prevalence of RA between 1990 and 2014 and to explore if there is any geographic variation in the incidence and prevalence of RA in the UK. Methods.: This was a primary care-based prospective cohort study. People contributing acceptable data to Clinical Practice Research Datalink between 1 January 1990 and 31 December 2014 were included. Read codes were used to identify RA cases ⩾18 years of age...
May 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28013209/the-incidence-prevalence-and-mortality-of-granulomatosis-with-polyangiitis-in-the-uk-clinical-practice-research-datalink
#7
Fiona A Pearce, Matthew J Grainge, Peter C Lanyon, Richard A Watts, Richard B Hubbard
Objective.: To estimate the incidence, prevalence and mortality of granulomatosis with polyangiitis in the UK. Methods.: We conducted a historical cohort study using data from the Clinical Practice Research Datalink and Hospital Episode Statistics (HES). We calculated incidence rate ratios, adjusted for age, gender and ethnicity, using Poisson regression. Results.: We identified 462 cases diagnosed between 1997 and 2013. Our overall estimate of incidence was 11...
April 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/27919934/development-and-validation-of-risk-prediction-model-for-venous-thromboembolism-in-postpartum-women-multinational-cohort-study
#8
Alyshah Abdul Sultan, Joe West, Matthew J Grainge, Richard D Riley, Laila J Tata, Olof Stephansson, Kate M Fleming, Catherine Nelson-Piercy, Jonas F Ludvigsson
OBJECTIVE:  To develop and validate a risk prediction model for venous thromboembolism in the first six weeks after delivery (early postpartum). DESIGN:  Cohort study. SETTING:  Records from England based Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics (HES) and data from Sweden based registry. PARTICIPANTS:  All pregnant women registered with CPRD-HES linked data between 1997 and 2014 and Swedish medical birth registry between 2005 and 2011 with postpartum follow-up...
December 5, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27872260/familial-aggregation-and-heritability-of-schizophrenia-and-co-aggregation-of-psychiatric-illnesses-in-affected-families
#9
I-Jun Chou, Chang-Fu Kuo, Yu-Shu Huang, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Lu-Shuang Huang, Wen-Yi Tseng, Weiya Zhang, Michael Doherty
Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of schizophrenia, and the relative risks (RRs) of other psychiatric diseases, in relatives of people with schizophrenia using the Taiwan National Health Insurance Database. The study population included individuals with affected first-degree or second-degree relatives identified from all beneficiaries (n = 23 422 955) registered in 2013...
November 21, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27802452/risk-of-venous-thromboembolism-in-people-with-lung-cancer-a-cohort-study-using-linked-uk-healthcare-data
#10
Alex J Walker, David R Baldwin, Tim R Card, Helen A Powell, Richard B Hubbard, Matthew J Grainge
No abstract text is available yet for this article.
March 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/27588834/early-clinical-features-in-systemic-lupus-erythematosus-can-they-be-used-to-achieve-earlier-diagnosis-a-risk-prediction-model
#11
Frances Rees, Michael Doherty, Peter Lanyon, Graham Davenport, Richard D Riley, Weiya Zhang, Matthew J Grainge
OBJECTIVE: To compare the primary care consulting behavior, prior to diagnosis, of people with systemic lupus erythematosus (SLE) with controls, and to develop and validate a risk prediction model to aid earlier SLE diagnosis. METHODS: We included a total of 1,739 incident SLE cases practice-matched to 6,956 controls from the UK Clinical Practice Research Datalink. Using logistic regression, odds ratios were calculated for age, sex, consultation rates, selected presenting clinical features, and previous diagnoses in the 5 years preceding diagnosis date...
September 2, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27583193/il-1%C3%AE-mediates-cellular-cross-talk-in-the-airway-epithelial-mesenchymal-trophic-unit
#12
Alison R Hill, Jessica E Donaldson, Cornelia Blume, Natalie Smithers, Liku Tezera, Kamran Tariq, Patrick Dennison, Hitasha Rupani, Matthew J Edwards, Peter H Howarth, Christopher Grainge, Donna E Davies, Emily J Swindle
The bronchial epithelium and underlying fibroblasts form an epithelial mesenchymal trophic unit (EMTU) which controls the airway microenvironment. We hypothesized that cell-cell communication within the EMTU propagates and amplifies the innate immune response to respiratory viral infections. EMTU co-culture models incorporating polarized (16HBE14o-) or differentiated primary human bronchial epithelial cells (HBECs) and fibroblasts were challenged with double-stranded RNA (dsRNA) or rhinovirus. In the polarized EMTU model, dsRNA affected ionic but not macromolecular permeability or cell viability...
July 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27461026/risk-of-venous-thromboembolism-in-hospitalised-cancer-patients-in-england-a-cohort-study
#13
Sonia Ratib, Alex J Walker, Tim R Card, Matthew J Grainge
BACKGROUND: Venous thromboembolism (VTE) is a well-recognised and life-threatening complication in patients with cancer. However, the precise risk of VTE in hospitalised cancer patients in England has not been previously reported. METHODS: We conducted a cohort study using linked Hospital Episodes Statistics and Office for National Statistics mortality data. We determined the risk of VTE separately for 24 cancer sites following first hospitalisation for cancer (index date) and how this varied by age, proximity from hospital admission, administration of chemotherapy and calendar time...
2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27274096/incidence-of-anca-associated-vasculitis-in-a-uk-mixed-ethnicity-population
#14
Fiona A Pearce, Peter C Lanyon, Matthew J Grainge, Reena Shaunak, Alfred Mahr, Richard B Hubbard, Richard A Watts
OBJECTIVES: We aimed to estimate the incidence of ANCA-associated vasculitis in the UK and how this varied by ethnic group. METHODS: We identified incident cases of ANCA-associated vasculitis between March 2007 and June 2013 in the Nottingham-Derby urban area from medical records using multiple sources. We derived the denominator population from the 2011 census, and we calculated incidence rate ratios using Poisson regression. RESULTS: Overall, we identified 107 cases of ANCA-associated vasculitis, giving an incidence of 23...
September 2016: Rheumatology
https://www.readbyqxmd.com/read/27253177/risk-of-venous-thromboembolism-in-people-with-lung-cancer-a-cohort-study-using-linked-uk-healthcare-data
#15
Alex J Walker, David R Baldwin, Tim R Card, Helen A Powell, Richard B Hubbard, Matthew J Grainge
BACKGROUND: Venous thromboembolism (VTE) is a potentially preventable cause of death in people with lung cancer. Identification of those most at risk and high-risk periods may provide the opportunity for better targeted intervention. METHODS: We conducted a cohort study using the Clinical Practice Research Datalink linked to Hospital Episode Statistics and Cancer Registry data. Our cohort comprises 10 598 people with lung cancer diagnosed between 1997 and 2006 with follow-up continuing to the end of 2010...
June 28, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/26748350/mortality-in-systemic-lupus-erythematosus-in-the-united-kingdom-1999-2012
#16
Frances Rees, Michael Doherty, Matthew J Grainge, Peter Lanyon, Graham Davenport, Weiya Zhang
OBJECTIVES: To estimate the mortality associated with SLE during the period 1999-2012 by age, gender and region; and to ascertain the cause of death for people with SLE. METHODS: A retrospective cohort study using the UK Clinical Practice Research Datalink. Incident SLE cases diagnosed between 1999 and 2012 were matched by age, sex and practice to four controls. Age-, gender- and region-specific mortality rates were calculated per 1000 person-years and compared with control mortality rates using mortality rate ratios (MRRs)...
May 2016: Rheumatology
https://www.readbyqxmd.com/read/26683193/impact-of-gout-on-the-risk-of-atrial-fibrillation
#17
Chang-Fu Kuo, Matthew J Grainge, Christian Mallen, Weiya Zhang, Michael Doherty
OBJECTIVES: To examine the risk of atrial fibrillation (AF) at the time of first diagnosis of gout compared with matched controls and to follow incident gout patients and their matched controls after diagnosis to compare their subsequent risk of AF. METHODS: From the UK Clinical Practice Research Data-link, 45 378 incident gout patients and 45 378 age-, sex-, practice-, registration year- and index year-matched controls were identified. Index dates were initial diagnosis date for gout patients and their matched controls...
April 2016: Rheumatology
https://www.readbyqxmd.com/read/26560059/defining-venous-thromboembolism-and-measuring-its-incidence-using-swedish-health-registries-a-nationwide-pregnancy-cohort-study
#18
Alyshah Abdul Sultan, Joe West, Olof Stephansson, Matthew J Grainge, Laila J Tata, Kate M Fleming, David Humes, Jonas F Ludvigsson
OBJECTIVE: To accurately define venous thromboembolism (VTE) in the routinely collected Swedish health registers and quantify its incidence in and around pregnancy. STUDY DESIGN: Cohort study using data from the Swedish Medical Birth Registry (MBR) linked to the National Patient Registry (NPR) and the Swedish Prescribed Drug Register (PDR). SETTING: Secondary care centres, Sweden. PARTICIPANT: 509,198 women aged 15-44 years who had one or more pregnancies resulting in a live birth or stillbirth between 2005 and 2011...
November 11, 2015: BMJ Open
https://www.readbyqxmd.com/read/26473719/burden-of-comorbidity-in-systemic-lupus-erythematosus-in-the-uk-1999-2012
#19
Frances Rees, Michael Doherty, Matthew Grainge, Peter Lanyon, Graham Davenport, Weiya Zhang
OBJECTIVE: To estimate the comorbidity associated with systemic lupus erythematosus (SLE) in the UK during 1999-2012. METHODS: A retrospective cohort study using the UK Clinical Practice Research Datalink was conducted. Prevalent cases of SLE were matched by age, sex, and practice to 4 controls. The incidence of cardiovascular disease (CVD), stroke, end-stage renal failure (ESRF), cancer, osteoporosis, and infection were calculated per 1,000 person-years during the study period and compared to controls using Poisson regression to obtain incidence rate ratios (IRRs)...
June 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/26193127/familial-aggregation-of-systemic-lupus-erythematosus-and-coaggregation-of-autoimmune-diseases-in-affected-families
#20
Chang-Fu Kuo, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Shue-Fen Luo, Kuang-Hui Yu, Weiya Zhang, Michael Doherty
IMPORTANCE: Relatives of patients with systemic lupus erythematosus (SLE) appear to be at higher risk of SLE and other autoimmune diseases, but estimates of individual familial risks are largely unavailable or unreliable. Furthermore, relative contributions of genetic, shared, and unshared environmental factors to SLE susceptibility remain unclear. OBJECTIVE: To examine familial aggregation and heritability of SLE and the relative risks (RRs) of other autoimmune diseases in relatives of patients with SLE...
September 2015: JAMA Internal Medicine
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