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Matthew grainge

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https://www.readbyqxmd.com/read/27919934/development-and-validation-of-risk-prediction-model-for-venous-thromboembolism-in-postpartum-women-multinational-cohort-study
#1
Alyshah Abdul Sultan, Joe West, Matthew J Grainge, Richard D Riley, Laila J Tata, Olof Stephansson, Kate M Fleming, Catherine Nelson-Piercy, Jonas F Ludvigsson
OBJECTIVE:  To develop and validate a risk prediction model for venous thromboembolism in the first six weeks after delivery (early postpartum). DESIGN:  Cohort study. SETTING:  Records from England based Clinical Practice Research Datalink (CPRD) linked to Hospital Episode Statistics (HES) and data from Sweden based registry. PARTICIPANTS:  All pregnant women registered with CPRD-HES linked data between 1997 and 2014 and Swedish medical birth registry between 2005 and 2011 with postpartum follow-up...
December 5, 2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/27872260/familial-aggregation-and-heritability-of-schizophrenia-and-co-aggregation-of-psychiatric-illnesses-in-affected-families
#2
I-Jun Chou, Chang-Fu Kuo, Yu-Shu Huang, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Lu-Shuang Huang, Wen-Yi Tseng, Weiya Zhang, Michael Doherty
Strong familial aggregation of schizophrenia has been reported but there is uncertainty concerning the degree of genetic contribution to the phenotypic variance of the disease. This study aimed to examine the familial aggregation and heritability of schizophrenia, and the relative risks (RRs) of other psychiatric diseases, in relatives of people with schizophrenia using the Taiwan National Health Insurance Database. The study population included individuals with affected first-degree or second-degree relatives identified from all beneficiaries (n = 23 422 955) registered in 2013...
November 21, 2016: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/27802452/risk-of-venous-thromboembolism-in-people-with-lung-cancer-a-cohort-study-using-linked-uk-healthcare-data
#3
Alex J Walker, David R Baldwin, Tim R Card, Helen A Powell, Richard B Hubbard, Matthew J Grainge
No abstract text is available yet for this article.
November 1, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/27588834/early-clinical-features-in-systemic-lupus-erythematosus-can-they-be-used-to-achieve-earlier-diagnosis-a-risk-prediction-model
#4
Frances Rees, Michael Doherty, Peter Lanyon, Graham Davenport, Richard D Riley, Weiya Zhang, Matthew J Grainge
OBJECTIVES: 1) To compare the primary care consulting behaviour prior to diagnosis of people with Systemic Lupus Erythematosus (SLE) with controls, 2) to develop and validate a risk prediction model to aid earlier SLE diagnosis. METHODS: 1,739 incident SLE cases practice-matched to 6,956 controls from the UK Clinical Practice Research Datalink. Odds ratios were calculated for age, gender, consultation rates, selected presenting clinical features and previous diagnoses in the 5 years preceding diagnosis date using logistic regression...
September 2, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27583193/il-1%C3%AE-mediates-cellular-cross-talk-in-the-airway-epithelial-mesenchymal-trophic-unit
#5
Alison R Hill, Jessica E Donaldson, Cornelia Blume, Natalie Smithers, Liku Tezera, Kamran Tariq, Patrick Dennison, Hitasha Rupani, Matthew J Edwards, Peter H Howarth, Christopher Grainge, Donna E Davies, Emily J Swindle
The bronchial epithelium and underlying fibroblasts form an epithelial mesenchymal trophic unit (EMTU) which controls the airway microenvironment. We hypothesized that cell-cell communication within the EMTU propagates and amplifies the innate immune response to respiratory viral infections. EMTU co-culture models incorporating polarized (16HBE14o-) or differentiated primary human bronchial epithelial cells (HBECs) and fibroblasts were challenged with double-stranded RNA (dsRNA) or rhinovirus. In the polarized EMTU model, dsRNA affected ionic but not macromolecular permeability or cell viability...
July 2016: Tissue Barriers
https://www.readbyqxmd.com/read/27461026/risk-of-venous-thromboembolism-in-hospitalised-cancer-patients-in-england-a-cohort-study
#6
Sonia Ratib, Alex J Walker, Tim R Card, Matthew J Grainge
BACKGROUND: Venous thromboembolism (VTE) is a well-recognised and life-threatening complication in patients with cancer. However, the precise risk of VTE in hospitalised cancer patients in England has not been previously reported. METHODS: We conducted a cohort study using linked Hospital Episodes Statistics and Office for National Statistics mortality data. We determined the risk of VTE separately for 24 cancer sites following first hospitalisation for cancer (index date) and how this varied by age, proximity from hospital admission, administration of chemotherapy and calendar time...
2016: Journal of Hematology & Oncology
https://www.readbyqxmd.com/read/27274096/incidence-of-anca-associated-vasculitis-in-a-uk-mixed-ethnicity-population
#7
Fiona A Pearce, Peter C Lanyon, Matthew J Grainge, Reena Shaunak, Alfred Mahr, Richard B Hubbard, Richard A Watts
OBJECTIVES: We aimed to estimate the incidence of ANCA-associated vasculitis in the UK and how this varied by ethnic group. METHODS: We identified incident cases of ANCA-associated vasculitis between March 2007 and June 2013 in the Nottingham-Derby urban area from medical records using multiple sources. We derived the denominator population from the 2011 census, and we calculated incidence rate ratios using Poisson regression. RESULTS: Overall, we identified 107 cases of ANCA-associated vasculitis, giving an incidence of 23...
September 2016: Rheumatology
https://www.readbyqxmd.com/read/27253177/risk-of-venous-thromboembolism-in-people-with-lung-cancer-a-cohort-study-using-linked-uk-healthcare-data
#8
Alex J Walker, David R Baldwin, Tim R Card, Helen A Powell, Richard B Hubbard, Matthew J Grainge
BACKGROUND: Venous thromboembolism (VTE) is a potentially preventable cause of death in people with lung cancer. Identification of those most at risk and high-risk periods may provide the opportunity for better targeted intervention. METHODS: We conducted a cohort study using the Clinical Practice Research Datalink linked to Hospital Episode Statistics and Cancer Registry data. Our cohort comprises 10 598 people with lung cancer diagnosed between 1997 and 2006 with follow-up continuing to the end of 2010...
June 28, 2016: British Journal of Cancer
https://www.readbyqxmd.com/read/26748350/mortality-in-systemic-lupus-erythematosus-in-the-united-kingdom-1999-2012
#9
Frances Rees, Michael Doherty, Matthew J Grainge, Peter Lanyon, Graham Davenport, Weiya Zhang
OBJECTIVES: To estimate the mortality associated with SLE during the period 1999-2012 by age, gender and region; and to ascertain the cause of death for people with SLE. METHODS: A retrospective cohort study using the UK Clinical Practice Research Datalink. Incident SLE cases diagnosed between 1999 and 2012 were matched by age, sex and practice to four controls. Age-, gender- and region-specific mortality rates were calculated per 1000 person-years and compared with control mortality rates using mortality rate ratios (MRRs)...
May 2016: Rheumatology
https://www.readbyqxmd.com/read/26683193/impact-of-gout-on-the-risk-of-atrial-fibrillation
#10
Chang-Fu Kuo, Matthew J Grainge, Christian Mallen, Weiya Zhang, Michael Doherty
OBJECTIVES: To examine the risk of atrial fibrillation (AF) at the time of first diagnosis of gout compared with matched controls and to follow incident gout patients and their matched controls after diagnosis to compare their subsequent risk of AF. METHODS: From the UK Clinical Practice Research Data-link, 45 378 incident gout patients and 45 378 age-, sex-, practice-, registration year- and index year-matched controls were identified. Index dates were initial diagnosis date for gout patients and their matched controls...
April 2016: Rheumatology
https://www.readbyqxmd.com/read/26560059/defining-venous-thromboembolism-and-measuring-its-incidence-using-swedish-health-registries-a-nationwide-pregnancy-cohort-study
#11
Alyshah Abdul Sultan, Joe West, Olof Stephansson, Matthew J Grainge, Laila J Tata, Kate M Fleming, David Humes, Jonas F Ludvigsson
OBJECTIVE: To accurately define venous thromboembolism (VTE) in the routinely collected Swedish health registers and quantify its incidence in and around pregnancy. STUDY DESIGN: Cohort study using data from the Swedish Medical Birth Registry (MBR) linked to the National Patient Registry (NPR) and the Swedish Prescribed Drug Register (PDR). SETTING: Secondary care centres, Sweden. PARTICIPANT: 509,198 women aged 15-44 years who had one or more pregnancies resulting in a live birth or stillbirth between 2005 and 2011...
November 11, 2015: BMJ Open
https://www.readbyqxmd.com/read/26473719/burden-of-comorbidity-in-systemic-lupus-erythematosus-in-the-uk-1999-2012
#12
Frances Rees, Michael Doherty, Matthew Grainge, Peter Lanyon, Graham Davenport, Weiya Zhang
OBJECTIVE: To estimate the comorbidity associated with systemic lupus erythematosus (SLE) in the UK during 1999-2012. METHODS: A retrospective cohort study using the UK Clinical Practice Research Datalink was conducted. Prevalent cases of SLE were matched by age, sex, and practice to 4 controls. The incidence of cardiovascular disease (CVD), stroke, end-stage renal failure (ESRF), cancer, osteoporosis, and infection were calculated per 1,000 person-years during the study period and compared to controls using Poisson regression to obtain incidence rate ratios (IRRs)...
June 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/26193127/familial-aggregation-of-systemic-lupus-erythematosus-and-coaggregation-of-autoimmune-diseases-in-affected-families
#13
Chang-Fu Kuo, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Shue-Fen Luo, Kuang-Hui Yu, Weiya Zhang, Michael Doherty
IMPORTANCE: Relatives of patients with systemic lupus erythematosus (SLE) appear to be at higher risk of SLE and other autoimmune diseases, but estimates of individual familial risks are largely unavailable or unreliable. Furthermore, relative contributions of genetic, shared, and unshared environmental factors to SLE susceptibility remain unclear. OBJECTIVE: To examine familial aggregation and heritability of SLE and the relative risks (RRs) of other autoimmune diseases in relatives of patients with SLE...
September 2015: JAMA Internal Medicine
https://www.readbyqxmd.com/read/26170376/effect-of-allopurinol-on-all-cause-mortality-in-adults-with-incident-gout-propensity-score-matched-landmark-analysis
#14
Chang-Fu Kuo, Matthew J Grainge, Christian Mallen, Weiya Zhang, Michael Doherty
OBJECTIVE: To examine the association between allopurinol use and all-cause mortality for patients with incident gout. METHODS: We compared all-cause mortality in incident gout patients who received allopurinol for at least 6 months within the exposure window (1 year or 3 years) with those who did not, using the UK Clinical Practice Research Data-link. Landmark analysis was used to account for immortal time bias and propensity score matching was used to control for potential effects of known confounders...
December 2015: Rheumatology
https://www.readbyqxmd.com/read/26150127/global-epidemiology-of-gout-prevalence-incidence-and-risk-factors
#15
REVIEW
Chang-Fu Kuo, Matthew J Grainge, Weiya Zhang, Michael Doherty
Gout is a crystal-deposition disease that results from chronic elevation of uric acid levels above the saturation point for monosodium urate (MSU) crystal formation. Initial presentation is mainly severely painful episodes of peripheral joint synovitis (acute self-limiting 'attacks') but joint damage and deformity, chronic usage-related pain and subcutaneous tophus deposition can eventually develop. The global burden of gout is substantial and seems to be increasing in many parts of the world over the past 50 years...
November 2015: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/25940005/familial-risk-of-sj%C3%A3-gren-s-syndrome-and-co-aggregation-of-autoimmune-diseases-in-affected-families-a-nationwide-population-study
#16
Chang-Fu Kuo, Matthew J Grainge, Ana M Valdes, Lai-Chu See, Shue-Fen Luo, Kuang-Hui Yu, Weiya Zhang, Michael Doherty
OBJECTIVE: To investigate familial aggregation of Sjögren's syndrome (SS) and the relative risks (RRs) of other autoimmune disease in relatives of patients with SS. METHODS: We identified 23,658,577 beneficiaries enrolled in the Taiwan National Health Insurance system in 2010, of whom 12,754 had SS. We identified 21,009,551 parent-child relationships and 17,168,340 pairs of full siblings. The familial risks of SS and other autoimmune diseases, tetrachoric correlation, and familial transmission were estimated...
July 2015: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/25612613/epidemiology-and-management-of-gout-in-taiwan-a-nationwide-population-study
#17
Chang-Fu Kuo, Matthew J Grainge, Lai-Chu See, Kuang-Hui Yu, Shue-Fen Luo, Weiya Zhang, Michael Doherty
INTRODUCTION: Gout is the most common inflammatory arthritis worldwide and is the only type of chronic arthritis that potentially can be 'cured'. However, data on gout incidence, prevalence and management, assessed at multiple time points in the same population, are sparse, particularly in Asian populations. The aim of this study was to describe trends in the epidemiology of gout in the general population of Taiwan. METHODS: The National Health Insurance Research Database was used to identify patients with gout and to estimate the prevalence and incidence of gout for each calendar year from 2005 to 2010...
2015: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/25536262/eligibility-for-and-prescription-of-urate-lowering-treatment-in-patients-with-incident-gout-in-england
#18
Chang-Fu Kuo, Matthew J Grainge, Christian Mallen, Weiya Zhang, Michael Doherty
No abstract text is available yet for this article.
December 24, 2014: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/25398375/comorbidities-in-patients-with-gout-prior-to-and-following-diagnosis-case-control-study
#19
Chang-Fu Kuo, Matthew J Grainge, Christian Mallen, Weiya Zhang, Michael Doherty
OBJECTIVES: To determine the burden of comorbidities in patients with gout at diagnosis and the risk of developing new comorbidities post diagnosis. METHODS: There were 39 111 patients with incident gout and 39 111 matched controls identified from the UK Clinical Practice Research Data-link. The risk of comorbidity before (ORs) and after the diagnosis of gout (HRs) were estimated, adjusted for age, sex, diagnosis year, body mass index, smoking and alcohol consumption...
January 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/25265938/the-incidence-and-prevalence-of-systemic-lupus-erythematosus-in-the-uk-1999-2012
#20
Frances Rees, Michael Doherty, Matthew Grainge, Graham Davenport, Peter Lanyon, Weiya Zhang
OBJECTIVES: To estimate the incidence and prevalence of systemic lupus erythematosus (SLE) in the UK over the period 1999-2012. METHODS: A retrospective cohort study using the Clinical Practice Research Datalink (CPRD). The incidence was calculated per 100 000 person-years and the prevalence was calculated per 100 000 people for the period 1999-2012 and stratified by year, age group, gender, region and ethnicity. Three definitions of SLE were explored: (1) systemic lupus, (2) a fully comprehensive definition of lupus including cutaneous only lupus and (3) requiring supporting evidence of SLE in the medical record...
January 2016: Annals of the Rheumatic Diseases
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