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https://www.readbyqxmd.com/read/29351369/heparin-but-not-tissue-plasminogen-activator-improves-outcomes-in-dcd-liver-transplantation-in-a-porcine-model
#1
Amelia J Hessheimer, Marina Vendrell, Javier Muñoz, Ángel Ruíz, Alba Díaz, Luís Flores Sigüenza, Jorge Rodríguez Lanzilotta, Eduardo Delgado Oliver, Jose Fuster, Miquel Navasa, Juan Carlos García-Valdecasas, Pilar Taurá, Constantino Fondevila
BACKGROUND: Ischemic type biliary lesions arise most frequently after DCD liver transplantation and result in high morbidity and graft loss. Many DCD grafts are discarded out of fear for this complication. In theory, microvascular thrombi deposited during donor warm ischemia might be implicated in ITBL pathogenesis. Herein, we aim to evaluate the effects of the administration of either heparin or the fibrinolytic drug TPA as means to improve DCD liver graft quality and potentially avoid ITBL...
January 19, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29351359/cyr61-ccn1-regulates-sclerostin-levels-and-bone-maintenance
#2
Gexin Zhao, Bau-Lin Huang, Diana Rigueur, Weiguang Wang, Chimay Bhoot, Kemberly R Charles, Jongseung Baek, Subburaman Mohan, Jie Jiang, Karen M Lyons
CYR61/CCN1 is a matricellular protein that resides in the extracellular matrix, but serves regulatory rather than structural roles. CYR61/CCN1 is found in mineralized tissues and has been shown to influence bone healing in vivo and osteogenic differentiation in vitro. In this study we generated Cyr61 bone specific knockout mice to examine the physiological role of CYR61/CCN1 in bone development and maintenance in vivo. Extensive analysis of Cyr61 conditional knockout mice showed a significant decrease in both trabecular and cortical bone mass as compared to WT littermate...
January 19, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29350888/identification-of-p90-ribosomal-s6-kinase-2-as-a-novel-host-protein-in-hbx-augmenting-hbv-replication-by-itraq-based-quantitative-comparative-proteomics
#3
Li-Bo Yan, You-Jia Yu, Qing-Bo Zhang, Xiao-Qiong Tang, Lang Bai, FeiJun Huang, Hong Tang
PURPOSE: The aim of this study was to screen for novel host proteins that play a role in HBx augmenting HBV replication. EXPERIMENTAL DESIGN: Three HepG2 cell lines stably harboring different functional domain of HBx (HBx, HBx-Cm6, and HBx-Cm16) were cultured. ITRAQ technology integrated with LC-MS/MS analysis was applied to identify the proteome differences among these three cell lines. RESULTS: In brief, a total of 70 different proteins were identified among HepG2-HBx, HepG2-HBx-Cm6, and HepG2-HBx-Cm16 by double repetition...
January 19, 2018: Proteomics. Clinical Applications
https://www.readbyqxmd.com/read/29350887/species-specific-clinical-characteristics-of-human-coronavirus-infection-among-otherwise-healthy-adolescents-and-adults
#4
Monique Bouvier, Wei-Ju Chen, John C Arnold, Mary P Fairchok, Patrick J Danaher, Tahaniyat Lalani, Leslie Malone, Deepika Mor, Michelande Ridoré, Timothy H Burgess, Eugene V Millar
Human coronavirus (HCoV) is a known cause of influenza-like illness (ILI). In a multi-site, observational, longitudinal study of ILI among otherwise healthy adolescents and adults, 12% of subjects were PCR-positive for HCoV. The distribution of species was as follows: HCoV-OC43 (34%), HCoV-229E (28%), HCoV-NL63 (22%), and HCoV-HKU1 (16%). We did not observe species-specific differences in the clinical characteristics of HCoV infection, with the exception of HCoV-HKU1, for which the severity of gastrointestinal symptoms trended higher on the fourth day of illness...
January 19, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29350885/unexpected-impact-of-esterification-on-the-antioxidant-activity-and-photo-stability-of-a-eumelanin-from-5-6-dihydroxyindole-2-carboxylic-acid
#5
Raffaella Micillo, Mariagrazia Iacomino, Marco Perfetti, Lucia Panzella, Kenzo Koike, Gerardino D'Errico, Marco d'Ischia, Alessandra Napolitano
To inquire into the role of the carboxyl group as determinant of the properties of 5,6-dihydroxyindole melanins, melanins from aerial oxidation of 5,6-dihydroxyindole (DHICA) and its methyl ester MeDHICA were comparatively tested for their antioxidant activity. MALDI MS spectrometry analysis of MeDHICA melanin provided evidence for a collection of intact oligomers. EPR analysis showed g-values almost identical and signal amplitudes (ΔB) comparable to those of DHICA melanin, but spin density was one order of magnitude higher, with a different response to pH changes...
January 19, 2018: Pigment Cell & Melanoma Research
https://www.readbyqxmd.com/read/29350882/cardiac-function-by-three-dimensional-speckle-tracking-imaging-and-cytokines-in-kawasaki-disease
#6
Masataka Kato, Mamoru Ayusawa, Hirofumi Watanabe, Akiko Komori, Yuriko Abe, Takahiro Nakamura, Hiroshi Kamiyama, Shori Takahashi
BACKGROUND: IT is well known that serum N-terminal pro brain natriuretic peptide (NT-proBNP) tends to elevate in acute phase of Kawasaki disease (KD), but the cause of NT-proBNP elevation has not been clarified. Our previous study revealed that cardiac function evaluated by two-dimensional echocardiography (2D-E) such as ejection fraction (EF) was normal. However, cardiac function evaluated by 2D-E does not reflect subtle change of cardiac dysfunction and the relation has still been controversial...
January 19, 2018: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29350881/interferon-induced-protein-35-ifi35-inhibits-endothelial-cell-proliferation-migration-and-re-endothelialization-of-injured-arteries-by-inhibiting-the-nuclear-factor-kappa-b-nf-kb-pathway
#7
Dongdong Jian, Weina Wang, Xinmiao Zhou, Zhen Jia, Jing Wang, Mei Yang, Wenting Zhao, Zhen Jiang, Xiaotong Hu, Jianhua Zhu
AIM: Endothelial recovery, or re-endothelialization, plays an important role in intimal hyperplasia and atherosclerosis after endothelial injury. Studying the mechanisms of re-endothelialization and strategies to promote efficient endothelial recovery are still needed. Interferon-induced protein 35 (IFI35) is an IFN-γ-induced protein that plays important roles in the anti-virus-related immune-inflammatory response. In this study, we tested whether overexpression IFI35 affects the proliferation and migration of endothelial cells (ECs) and re-endothelialization...
January 19, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29350880/temporal-and-spatial-quantification-of-pain-related-small-fiber-functionality-assessed-using-laser-speckle-contrast-analysis-lasca
#8
Isin Unal-Cevik
BACKGROUND: This study aimed to establish a practical method for assessing pain symptomatology and develop criteria for quantifying small fiber functions, using LASCA. METHODS: Axon flare responses, which reflect small fiber functions, were induced either by histamine or capsaicin applied to the volar surface of the skin of the left forearm. To inhibit small fiber function, local anesthetic cream was applied to the skin of right forearm. The effects on pain symptomatology (severity/timing) and axon flare responses (temporal/spatial characteristics) were measured using LASCA...
January 19, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29350879/genetic-and-chemical-diversity-in-perovskia-abrotanoides-karel-lamiaceae-populations-based-on-issrs-markers-and-essential-oils-profile
#9
Seyyed Hossein Pourhosseini, Javad Hadian, Ali Sonboli, Samad Nejad Ebrahimi, Mohammad Hossein Mirjalili
Genetic and the essential oil composition variability among twelve Perovskia abrotanoides populations (PAbPs) growing wild in Iran were assessed by ISSR markers, GC-FID and GC-MS, respectively. Nine selected ISSR primers produced 119 discernible bands, of them 96 (80.7%) being polymorphic. Genetic similarity values among populations ranged between 0.07 and 0.79 which indicated a high level of genetic variation. Polymorphic information content, resolving power and marker index generated by ISSR primers were, 0...
January 19, 2018: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29350878/perfusion-ct-in-posterior-circulation-stroke-predictors-and-prognostic-implications-of-focal-hypoperfusion
#10
Lars-Peder Pallesen, Dimitris Lambrou, Ashraf Eskandari, Jessica Barlinn, Kristian Barlinn, Heinz Reichmann, Vincent Dunet, Philippe Maeder, Volker Puetz, Patrik Michel
BACKGROUND: We aimed to determine predictors of focal hypoperfusion on CT Perfusion (CTP) in patients with acute posterior circulation stroke and its association with long-term outcome. METHODS: We selected patients with posterior circulation stroke from the Acute STroke Registry and Analysis of Lausanne (ASTRAL) who underwent CTP within 24 hours of stroke onset as part of the stroke imaging protocol. Hypoperfusion was defined as an area of visually well demarcated mean-transit-time (MTT) prolongation corresponding to an arterial territory on standard reconstruction CTP imaging maps...
January 19, 2018: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29350877/effects-of-human-rhinovirus-on-epithelial-barrier-integrity-and-function-in-children-with-asthma
#11
Kevin Looi, Alysia G Buckley, Paul J Rigby, Luke W Garratt, Thomas Iosifidis, Graeme R Zosky, Alexander N Larcombe, Francis J Lannigan, Kak-Ming Ling, Kelly M Martinovich, Elizabeth Kicic-Starcevich, Nicole C Shaw, Erika N Sutanto, Darryl A Knight, Anthony Kicic, Stephen M Stick
BACKGROUND: Bronchial epithelial tight junctions (TJ) have been extensively assessed in healthy airway epithelium. However, no studies have yet assessed the effect of human rhinovirus (HRV) infection on the expression and resultant barrier function in epithelial tight junctions (TJ) in childhood asthma. OBJECTIVES: To investigate the impact of HRV infection on airway epithelial TJ expression and barrier function in airway epithelial cells (AEC) of children with and without asthma...
January 19, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29350875/highly-dynamic-wintering-strategies-in-migratory-geese-coping-with-environmental-change
#12
Kevin Kuhlmann Clausen, Jesper Madsen, Fred Cottaar, Eckhart Kuijken, Christine Verscheure
When and where to move is a fundamental decision to migratory birds, and the fitness-related costs and benefits of migratory choices make them subject to strong selective forces. Site use and migration routes are outcomes of opportunities in the surrounding landscape, and the optimal migration strategy may be conservative or explorative depending on the variability of the environment occupied by the species. This study applies 25 years of resighting data to examine development in winter migration strategy of pink-footed geese divided among Denmark, the Netherlands and Belgium, and analyse potential drivers of strategy change as well as individuals' likelihood to break with migratory tradition...
January 19, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29350873/test-procedures-to-assess-somatosensory-abnormalities-in-individuals-with-peripheral-joint-pain-a-systematic-review-of-psychometric-properties
#13
REVIEW
Abdullah Alqarni, Donald Manlapaz, David Baxter, Steve Tumilty, Ramakrishnan Mani
BACKGROUND: Test procedures that were developed to assess somatosensory abnormalities should possess optimal psychometric properties (PMPs) to be used in clinical practice. The aim of this systematic review is to evaluate the literature to assess the level of evidence for PMPs of test procedures investigated in individuals with peripheral joint pain (PJP). METHODS: A comprehensive electronic literature search was conducted in seven databases from inception to March 2016...
January 19, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29350842/from-grey-to-green-efficacy-of-eco-engineering-solutions-for-nature-based-coastal-defence
#14
Rebecca L Morris, Teresa M Konlechner, Marco Ghisalberti, Stephen E Swearer
Climate change is increasing the threat of erosion and flooding along coastlines globally. Engineering solutions (e.g. seawalls and breakwaters) in response to protecting coastal communities and associated infrastructure are increasingly becoming economically and ecologically unsustainable. This has led to recommendations to create or restore natural habitats, such as sand dunes, saltmarsh, mangroves, seagrass and kelp beds, and coral and shellfish reefs, to provide coastal protection in place of (or to complement) artificial structures...
January 19, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29350841/epidemiology-and-molecular-characterization-of-influenza-viruses-in-burkina-faso-sub-saharan-africa
#15
Armel M Sanou, Sampoko Carine M Wandaogo, Armel Poda, Laure Tamini, Anselme E Kyere, Tani Sagna, Macaire S Ouedraogo, Maude Pauly, Judith M Hübschen, Claude P Muller, Zekiba Tarnagda, Chantal J Snoeck
BACKGROUND: The importance of influenza viruses in respiratory infections in sub-Saharan Africa has been historically overlooked, including in Burkina Faso. This study therefore aimed at evaluating the prevalence and seasonal occurrence of influenza viruses in children under five years old, at risk of influenza-related complications, presenting with influenza-like illness (ILI) or severe acute respiratory infection (SARI). The study also aimed at identifying the periods with increased influenza transmission for vaccination recommendations in Burkina Faso...
January 19, 2018: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29350833/platelets-kill-bacteria-by-bridging-innate-and-adaptive-immunity-via-pf4-and-fc%C3%AE-riia
#16
R Palankar, T P Kohler, K Krauel, J Wesche, S Hammerschmidt, A Greinacher
BACKGROUND: Activated platelets release the chemokine platelet factor 4 (PF4) stored in their granules. PF4 binds to polyanions (P) on bacteria, undergoes a conformational change and exposes neoepitopes. These neoepitopes induce production of anti-PF4/P antibodies. As PF4 binds to a variety of bacteria, anti-PF4/P IgG can bind and opsonize several bacterial species. OBJECTIVE: Here we investigated whether platelets are able to kill bacteria directly after recognizing anti-PF4/P IgG opsonized bacteria in the presence of PF4 via their FcγRIIA...
January 19, 2018: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29350831/randomized-trial-on-extended-versus-modified-right-lobe-grafts-in-live-donor-liver-transplantation
#17
Christi Titus Varghese, Viju Kumar Bharathan, Unnikrishnan Gopalakrishnan, Dinesh Balakrishnan, Ramachandran N Menon, Othiyil Vayoth Sudheer, Puneet Dhar, Sudhindran Surendran
Despite advances in the practice of live donor liver transplantation (LDLT), the optimum surgical approach with respect to the middle hepatic vein (MHV) in right lobe LDLT remains undefined. We designed a randomized trial to compare the early postoperative outcomes in recipients and donors between extended right lobe grafts (ERG: transection plane was maintained to the left of MHV, and division of MHV performed beyond the segment VIII vein) and modified right lobe grafts (MRG: transection plane was maintained to the right of MHV, the segment V and VIII drainage was reconstructed using a conduit of recipient portal vein)...
January 19, 2018: Liver Transplantation
https://www.readbyqxmd.com/read/29350822/resveratrol-suppresses-rotenone-induced-neurotoxicity-through-activation-of-sirt1-akt1-signaling-pathway
#18
Hui Wang, Xiaoguang Dong, Zengxun Liu, Shaowei Zhu, Haili Liu, Wenchuang Fan, Yanlai Hu, Tao Hu, Yonghui Yu, Yizhao Li, Tianwei Liu, Chengjia Xie, Qing Gao, Guibao Li, Jing Zhang, Zhaoxi Ding, Jinhao Sun
Rotenone is a common pesticide and has been reported as one of the risk factors for Parkinson disease. Rotenone can cause neuronal death or apoptosis through inducing oxidative injury and inhibiting mitochondrial function. As a natural polyphenolic compound, resveratrol possesses the anti-oxidant capacity and neuroprotective effect. However, the mechanism underlying the neuroprotective effect of resveratrol against rotenone-induced neurotoxicity remains elusive. Here, we treated PC12 cells with rotenone to induce neurotoxicity, and the neurotoxic cells were subjected to resveratrol treatment...
January 19, 2018: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/29350812/a-unified-framework-of-plant-adaptive-strategies-to-drought-crossing-scales-and-disciplines
#19
Florence Volaire
Plant adaptation to drought has been extensively studied at many scales from ecology to molecular biology across a large range of model species. However, the conceptual frameworks underpinning the definition of plant strategies, and the terminology used across the different disciplines and scales are not analogous. 'Drought resistance' for instance refers to plant responses as different as the maintenance of growth and productivity in crops, to the survival and recovery in perennial woody or grassland species...
January 19, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29350807/mait-cells-and-viruses
#20
James E Ussher, Christian B Willberg, Paul Klenerman
Mucosal associated invariant T cells (MAIT cells) bear a T cell receptor (TCR) that specifically targets microbially-derived metabolites. Functionally they respond to bacteria and yeasts, which possess the riboflavin pathway, essential for production of such metabolites and which are presented on MR1. Viruses cannot generate these ligands, so a priori, they should not be recognized by MAIT cells and indeed this is true when considering recognition through the TCR. However, MAIT cells are distinctive in another respect, since they respond quite sensitively to non-TCR signals, especially in the form of inflammatory cytokines...
January 19, 2018: Immunology and Cell Biology
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