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Dementia research

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https://www.readbyqxmd.com/read/28943731/multi-source-multi-target-dictionary-learning-for-prediction-of-cognitive-decline
#1
Jie Zhang, Qingyang Li, Richard J Caselli, Paul M Thompson, Jieping Ye, Yalin Wang
Alzheimer's Disease (AD) is the most common type of dementia. Identifying correct biomarkers may determine pre-symptomatic AD subjects and enable early intervention. Recently, Multi-task sparse feature learning has been successfully applied to many computer vision and biomedical informatics researches. It aims to improve the generalization performance by exploiting the shared features among different tasks. However, most of the existing algorithms are formulated as a supervised learning scheme. Its drawback is with either insufficient feature numbers or missing label information...
June 2017: Information Processing in Medical Imaging: Proceedings of the ... Conference
https://www.readbyqxmd.com/read/28943482/atrial-fibrillation-and-cognitive-decline-in-the-framingham-heart-study
#2
Arvind Nishtala, Ryan J Piers, Jayandra J Himali, Alexa S Beiser, Kendra L Davis-Plourde, Jane S Saczynski, David D McManus, Emelia J Enjamin, Rhoda Au
BACKGROUND: There is a paucity of longitudinal research investigating the relations between AF and domain-specific cognitive performance. OBJECTIVE: Our study investigated the association between AF and cognitive performance cross-sectionally and longitudinally. METHODS: Eligible participants were dementia- and stroke-free at the time of baseline neuropsychological (NP) assessment, and underwent at least one additional NP assessment with a one year or greater inter-test interval...
September 21, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28942203/potentially-inappropriate-medication-association-between-the-use-of-antidepressant-drugs-and-the-subsequent-risk-for-dementia
#3
Kathrin Heser, Tobias Luck, Susanne Röhr, Birgitt Wiese, Hanna Kaduszkiewicz, Anke Oey, Horst Bickel, Edelgard Mösch, Siegfried Weyerer, Jochen Werle, Christian Brettschneider, Hans-Helmut König, Angela Fuchs, Michael Pentzek, Hendrik van den Bussche, Martin Scherer, Wolfgang Maier, Steffi G Riedel-Heller, Michael Wagner
BACKGROUND: Potentially inappropriate medication (PIM) is associated with an increased risk for detrimental health outcomes in elderly patients. Some antidepressant drugs are considered as PIM, but previous research on the association between antidepressants and subsequent dementia has been inconclusive. Therefore, we investigated whether the intake of antidepressants, particularly of those considered as PIM according to the Priscus list, would predict incident dementia. METHODS: We used data of a prospective cohort study of non-demented primary care patients (n = 3239, mean age = 79...
September 14, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28940317/systematic-review-effective-home-support-in-dementia-care-components-and-impacts-stage-2-effectiveness-of-home-support-interventions
#4
REVIEW
Paul Clarkson, Jane Hughes, Brenda Roe, Clarissa M Giebel, David Jolley, Fiona Poland, Michele Abendstern, Helen Chester, David Challis
AIM: To explicate the outcomes of home support interventions for older people with dementia and/or their carers to inform clinical practice, policy and research. BACKGROUND: Most people with dementia receive support at home. However, components and effectiveness of home support interventions have been little explored. DESIGN: Systematic review with narrative summary. DATA SOURCES: Electronic searches of published studies in English using PubMed, Cochrane Central Register of Controlled Trials, PsychINFO, CINAHL, Applied Social Science Index and CSA Social Services Abstracts...
September 20, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28940127/diagnostic-accuracy-of-memory-measures-in-alzheimer-s-dementia-and-mild-cognitive-impairment-a-systematic-review-and-meta-analysis
#5
REVIEW
Gali H Weissberger, Jessica V Strong, Kayla B Stefanidis, Mathew J Summers, Mark W Bondi, Nikki H Stricker
With an increasing focus on biomarkers in dementia research, illustrating the role of neuropsychological assessment in detecting mild cognitive impairment (MCI) and Alzheimer's dementia (AD) is important. This systematic review and meta-analysis, conducted in accordance with PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) standards, summarizes the sensitivity and specificity of memory measures in individuals with MCI and AD. Both meta-analytic and qualitative examination of AD versus healthy control (HC) studies (n = 47) revealed generally high sensitivity and specificity (≥ 80% for AD comparisons) for measures of immediate (sensitivity = 87%, specificity = 88%) and delayed memory (sensitivity = 89%, specificity = 89%), especially those involving word-list recall...
September 22, 2017: Neuropsychology Review
https://www.readbyqxmd.com/read/28937953/the-biological-basis-of-chronic-traumatic-encephalopathy-following-blast-injury-a-literature-review
#6
Matt Aldag, Regina C Armstrong, Faris Bandak, Patrick S F Bellgowan, Timothy Bentley, Sean Biggerstaff, Katrina Caravelli, Joan Cmarik, Alicia Crowder, Thomas J DeGraba, Travis A Dittmer, Richard G Ellenbogen, Colin Greene, Raj K Gupta, Ramona Hicks, Stuart Hoffman, Robert C Latta, Michael J Leggieri, Donald Marion, Robert Mazzoli, Michael McCrea, John O'Donnell, Mark Packer, James B Petro, Todd E Rasmussen, Wendy Sammons-Jackson, Richard Shoge, Victoria Tepe, Ladd A Tremaine, James Zheng
The United States Department of Defense Blast Injury Research Program Coordinating Office organized the 2015 International State-of-the-Science meeting to explore links between blast-related head injury and the development of chronic traumatic encephalopathy (CTE). Before the meeting, the planning committee examined articles published between 2005 and October 2015 and prepared this literature review, which summarized broadly CTE research and addressed questions about the pathophysiological basis of CTE and its relationship to blast- and nonblast-related head injury...
September 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28936936/-treatment-of-dementia
#7
K Blom, G A H van den Elsen, H L Koek, J B Sanders, H C Kruithof, J A H R Claassen
- Treatment options for patients with dementia are limited. This article provides an overview of possible interventions, both pharmaceutical and non-pharmaceutical, for Alzheimer's disease, vascular dementia and mixed dementia.- Pharmaceutical treatment options include cholinesterase inhibitors, memantine and experimental medication. Cholinesterase inhibitors are only recommended for Alzheimer's disease and mixed dementia, not for vascular dementia or mild cognitive impairment. There is no proof of effectiveness for the other pharmaceutical options...
2017: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/28936121/a-mixed-method-study-of-an-education-intervention-to-reduce-use-of-restraint-and-implement-person-centered-dementia-care-in-nursing-homes
#8
Frode F Jacobsen, Tone Elin Mekki, Oddvar Førland, Bjarte Folkestad, Øyvind Kirkevold, Randi Skår, Eva Marie Tveit, Christine Øye
BACKGROUND: People living with dementia in nursing homes are most likely to be restrained. The primary aim of this mixed-method education intervention study was to investigate which factors hindered or facilitated staff awareness related to confidence building initiatives based on person-centred care, as an alternative to restraint in residents with dementia in nursing homes. The education intervention, consisting of a two-day seminar and monthly coaching sessions for six months, targeted nursing staff in 24 nursing homes in Western Norway...
2017: BMC Nursing
https://www.readbyqxmd.com/read/28936066/cognitive-impairment-in-rural-elderly-population-in-ecuador
#9
Xavier Wong-Achi, Gabriela Egas, Dayana Cabrera
INTRODUCTION: The Mini-Cog is a simple and short test that identifies cognitive impairment. Its detection helps provide an early dementia diagnosis, rapid access to treatments, and even delay or reversion. MATERIALS AND METHODS: This multicenter, observational, descriptive, and cross-sectional study included 214 patients. Patients enrolled in this study were community dwellers aged ≥55-year-old, without prior diagnosis of cognitive impairment or dementia, with adequate hearing and vision functions...
August 2017: Journal of Neurosciences in Rural Practice
https://www.readbyqxmd.com/read/28934622/should-i-stay-or-should-i-go-how-healthcare-professionals-close-encounters-with-people-with-dementia-in-the-acute-hospital-setting
#10
Rebecca Allwood, Alison Pilnick, Rebecca O'Brien, Sarah Goldberg, Rowan H Harwood, Suzanne Beeke
Around a quarter of hospital beds in the UK are occupied by patients living with dementia (PWD), and communication impairments are common across all types of dementia, often exacerbated by the hospital environment. Unsurprisingly, healthcare professionals (HCPs) report particular challenges in caring for this patient group, whilst trying to recognise and value their personhood as per the underpinning ethos of person-centred care. However, whilst there is a growing body of research that underlines the importance of communication in dementia care, there is far less that actually examines this communication in real time interaction...
September 9, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28933994/decision-making-for-people-living-with-dementia-by-their-carers-at-the-end-of-life-a-rapid-scoping-review
#11
Sue Barker, Mary Lynch, Jane Hopkinson
BACKGROUND: There are an increasing number of people living with dementia, as well as an expectation that care decisions are made collaboratively with those with the disease entering the end stage and their families. This has increased the burden on family carers. AIM: To explore the evidence on the decisional support needs of informal carers of people with end-stage dementia. DESIGN: A rapid scoping review was undertaken of peer-reviewed publications between 2000 and 2016, which included all health-care settings and the person's own home...
September 2, 2017: International Journal of Palliative Nursing
https://www.readbyqxmd.com/read/28933191/dementia-friendly-initiatives-a-state-of-the-science-review
#12
Catherine A Hebert, Kezia Scales
Background Dementia friendly initiatives share similarities with the age-friendly movement in a focus on active engagement and creating a good quality of life for older adults. Dementia friendly initiatives offer a welcoming optimistic narrative in dementia studies by embracing dignity, empowerment, and autonomy to enable well-being throughout the dementia trajectory. Purpose The purpose of this review is to explore the current science of dementia friendly initiatives, identify gaps, and inform future research...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/28931452/factors-associated-with-appropriate-psychotropic-drug-prescription-in-nursing-home-patients-with-severe-dementia
#13
Klaas van der Spek, Raymond Tcm Koopmans, Martin Smalbrugge, Marjorie Hjmg Nelissen-Vrancken, Roland B Wetzels, Claudia Hw Smeets, Steven Teerenstra, Sytse U Zuidema, Debby L Gerritsen
BACKGROUND: We studied the patient and non-patients factors of inappropriate psychotropic drug (PD) prescription for neuropsychiatric symptoms (NPS) in nursing home patients with severe dementia. METHODS: In a cross-sectional study, the appropriateness of prescriptions was explored using the Appropriate Psychotropic drug use In Dementia (APID) index sum score. This index assesses information from medical records on indication, evaluation, dosage, drug-drug interactions, drug-disease interactions, duplications, and therapy duration...
September 21, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28931446/prevalence-estimates-of-mild-behavioral-impairment-in-a-population-based-sample-of-pre-dementia-states-and-cognitively-healthy-older-adults
#14
Moyra E Mortby, Zahinoor Ismail, Kaarin J Anstey
BACKGROUND: A dearth of population-based epidemiological research examines neuropsychiatric symptom (NPS) in sub-clinical populations across the spectrum from normal aging to mild cognitive impairment (MCI). The construct of mild behavioral impairment (MBI) describes the emergence of sustained and impactful NPS in advance of or in combination with MCI. This is the first epidemiological study to operationalize the recently published diagnostic criteria for MBI and determine prevalence estimates across the spectrum from cognitively normal to MCI...
September 21, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/28930599/dissection-of-prodromal-alzheimer-s-disease
#15
Can Sheng, Yue Huang, Ying Han
Pathophysiological changes of Alzheimer's Disease (AD) begin decades before clinical symptoms become apparent, providing an important window for early diagnosis and intervention. Prodromal stage of AD, a great opportunity for effective treatment and postponing the disease onset, has drawn extensive attention. The application of different biomarkers including neuroimaging, biochemical substances and genes makes AD-related pathology detectable in vivo and exploring novel biomarkers with relatively non-invasive and low cost has intrigued a wide range of interests...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930593/precision-medicine-of-frontotemporal-dementia-from-genotype-to-phenotype
#16
Xiang-Qian Che, Ning Song, Ying Gao, Ru-Jing Ren, Gang Wang
Frontotemporal dementia (FTD) is the second most common neurodegenerative  cause of early-onset dementia. FTD has an important genetic component contributing to its pathogenic mechanisms. Currently, extensive research on neuroimaging biomarkers and neurochemical biomarkers in FTD is being conducted to address the clinical need for a sensitive and specific diagnostic marker. Here, we review the advances in genetics, biomarkers and treatment of FTD and how this may represent a shift towards precision medicine...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28930543/eeg-and-erp-biomarkers-of-alzheimer-s-disease-a-critical-review
#17
Andras Horvath, Anna Szucs, Gabor Csukly, Anna Sakovics, Gabor Stefanics, Anita Kamondi
Here we critically review studies that used electroencephalography (EEG) or event-related potential (ERP) indices as a biomarker of Alzheimer's disease. In the first part we overview studies that relied on visual inspection of EEG traces and spectral characteristics of EEG. Second, we survey analysis methods motivated by dynamical systems theory (DST) as well as more recent network connectivity approaches. In the third part we review studies of sleep.  Next, we compare the utility of early and late ERP components in dementia research...
January 1, 2018: Frontiers in Bioscience (Landmark Edition)
https://www.readbyqxmd.com/read/28929910/armed-and-aging-dementia-and-firearms-do-not-mix
#18
Gabriele Cipriani, Sabrina Danti, Cecilia Carlesi, Mario Di Fiorino
The possibility that persons with dementia possess firearms is cause for concern, but only a limited amount of research has been conducted on such a topic, usually in the form of case reports. Reducing the occurrence of the firearms-related violence requires effectively identifying dangerous individuals and keeping firearms out of their hands. The health care professionals, i.e. the social workers and the physicians, need to work together and to produce a suitable evaluation of patients with dementia to prevent firearm-related injuries and serious and irreparable damage to persons...
September 20, 2017: Journal of Gerontological Social Work
https://www.readbyqxmd.com/read/28929475/-mild-behavioural-impairment-as-an-antecedent-of-dementia-presentation-of-the-diagnostic-criteria-and-the-spanish-version-of-the-mbi-c-scale-for-its-evaluation
#19
REVIEW
L F Aguera-Ortiz, J Lopez-Alvarez, L Del Nido-Varo, E Soria Garcia-Rosel, D A Perez-Martinez, Z Ismail
INTRODUCTION: Neuropsychiatric symptoms are common in dementia and also in previous stages such as mild cognitive impairment. Their presence is related to greater conversion to dementia in cognitively healthy people or with mild cognitive impairment compared to those who do not suffer them. AIM: An international working group pertaining to the Alzheimer Association has proposed the concept of 'mild behavioral impairment' (MBI) to identify patients with mild neuropsychiatric symptoms and normal cognition or mild cognitive impairment and to study the further risk of developing dementia from any cause...
October 1, 2017: Revista de Neurologia
https://www.readbyqxmd.com/read/28927738/dmard-use-is-associated-with-a-higher-risk-of-dementia-in-patients-with-rheumatoid-arthritis-a-propensity-score-matched-case-control-study
#20
Ming-Hsien Chou, Jong-Yi Wang, Cheng-Li Lin, Wei-Sheng Chung
BACKGROUND: Patients with rheumatoid arthritis (RA) exhibit an increased risk of dementia. Disease-modifying antirheumatic drugs (DMARDs) are commonly used to slow RA progression, but studies investigating the relationship between DMARDs and dementia in patients with RA are lacking. We investigated the relationship between DMARDs and dementia in patients with RA. METHODS: Using the National Health Insurance Research Database, patients aged ≥20years, who were newly diagnosed with RA between 2000 and 2011 were identified...
September 16, 2017: Toxicology and Applied Pharmacology
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