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https://www.readbyqxmd.com/read/29163531/impaired-resolution-of-inflammation-in-alzheimer-s-disease-a-review
#1
REVIEW
Robert A Whittington, Emmanuel Planel, Niccolò Terrando
Alzheimer's disease (AD) remains the leading cause of dementia worldwide, and over the last several decades, the role of inflammation in the pathogenesis of this neurodegenerative disorder has been increasingly elucidated. The initiation of the acute inflammatory response is counterbalanced by an active process termed resolution. This process is designed to restore homeostasis and promote tissue healing by the activation of neutrophilic apoptosis, promotion of neutrophil clearance by macrophages, and increasing anti-inflammatory cytokine levels, while concurrently leading to a diminution in pro-inflammatory mediators...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29161395/postoperative-cognitive-dysfunction-and-dementia-what-we-need-to-know-and-do
#2
M J Needham, C E Webb, D C Bryden
Approximately 12% of apparently previously cognitively well patients undergoing anaesthesia and noncardiac surgery will develop symptoms of cognitive dysfunction after their procedure. Recent articles in this Journal have highlighted the difficulties of confirming any clear links between anaesthesia and cognitive dysfunction, in part because of the lack of consistency regarding definition and diagnosis. Postoperative cognitive dysfunction (POCD) is usually self-limiting and rarely persists in the longer term, although plausible biological mechanisms for an impact on brain protein deposition do exist...
December 1, 2017: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29161218/the-impact-of-dementia-on-relationships-intimacy-and-sexuality-in-later-life-couples-an-integrative-qualitative-analysis-of-existing-literature
#3
Kristen Holdsworth, Marita McCabe
OBJECTIVES: The onset and progression of dementia can have a profound effect on the couple dyad. The aim of this systematic review was to analyze the literature investigating the impact of dementia on the relationships, intimacy, and sexuality in older couples. METHODS: A systematic literature search was conducted in May 2016 for relevant research articles. Five databases were searched: Web of Science, PsycINFO, MedLine, Scopus and CINAHL. The reference lists of articles included in the review were screened along with the reference list of other relevant reviews...
September 15, 2017: Clinical Gerontologist
https://www.readbyqxmd.com/read/29158118/measuring-physiological-responses-to-the-arts-in-people-with-a-dementia
#4
REVIEW
George E C Thomas, Sebastian Crutch, Paul M Camic
The dementias are a group of progressive symptoms that have multiple causes, usually caused by disease or injury of the brain, affecting higher brain functions such as language, perception, memory, reasoning and mood; they can also be associated with changes in personality. Arts interventions and interaction with the arts can create meaningful, positive experiences for people with a dementia, as well as improve quality of life. Qualitative research in particular, has been able to describe the emotional responses the arts can produce, but quantifiable changes have not been well documented...
November 17, 2017: International Journal of Psychophysiology
https://www.readbyqxmd.com/read/29156941/supporting-family-dementia-caregivers-testing-the-efficacy-of-dementia-care-management-on-multifaceted-caregivers-burden
#5
I Zwingmann, W Hoffmann, B Michalowsky, A Dreier-Wolfgramm, J Hertel, D Wucherer, T Eichler, I Kilimann, F Thiel, S Teipel, J R Thyrian
OBJECTIVES: Current research suggests that dementia care management (DCM) can decrease burden and associated health impairments of caregivers. The objective of this secondary analysis is to investigate the impact of DCM on multifaceted caregivers' burden dimensions by differentiating between objective and subjective burden. METHODS: A sample of n = 317 dyads of caregivers and community-dwelling people with dementia (PwD) participated in a general practitioner-based, cluster-randomized intervention trial (Identifier:NCT01401582) with two arms and comprehensive data assessment at baseline and 12-month follow-up...
November 20, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/29155289/the-diagnostic-sensitivity-of-the-memorial-delirium-assessment-scale-mdas-spanish-version
#6
Elena Barahona, Rita Pinhao, Victoria Galindo, Antonio Noguera
Although Memorial Delirium Assessment Scale (MDAS) is a successful tool for delirium evaluation and monitoring, it is nevertheless important to determine whether cut-off scores vary according to the studied population. The main objective of this study is to evaluate the diagnostic sensitivity of the recently validated Spanish version of the MDAS. The secondary objective is to analyze possible diagnostic differences when used in a hospice or general hospital setting. METHODOLOGY: A prospective study was conducted with advanced cancer patients in two settings (hospice & general hospital)...
November 15, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/29155026/personalized-nanomedicine-for-cns-diseases
#7
REVIEW
Ajeet Kaushik, Rahul Dev Jayant, Vinay Bhardwaj, Madhavan Nair
Central nervous system (CNS) diseases are rapidly increasing globally. Currently used therapeutic agents to treat CNS diseases exhibit significant efficacy. However, the inability of these drugs to cross the blood-brain barrier (BBB) and invasiveness of the technologies to achieve localized drug delivery in disease-specific parts of the brain have thwarted pain-free and complete treatment of CNS diseases. Therefore, the safe, non-invasive, and targeted delivery of drugs to the brain using nanoparticles (NPs) is currently receiving considerable research attention...
November 15, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/29154688/substance-use-and-cognitive-function-as-drivers-of-condomless-anal-sex-among-hiv-positive-gay-bisexual-and-other-men-who-have-sex-with-men-aged-50-and-older-the-gold-studies
#8
Sandra A Kupprat, Kristen D Krause, Danielle C Ompad, Perry N Halkitis
PURPOSE: Substance use has been linked to the sexual transmission of HIV among gay, bisexual, and other men who have sex with men (MSM) across the lifespan. Among older, HIV-positive, MSM populations, cognitive dysfunction associated with age and HIV disease progression also may play a role in sexual risk-taking. People aged 50 years and older represent a growing proportion of the overall HIV-positive population. This study aimed to explore relationships between substance use and cognitive function, and their impact on condomless anal sex (CAS) among HIV-positive gay, bisexual, and other MSM aged 50 years and older...
November 20, 2017: LGBT Health
https://www.readbyqxmd.com/read/29153920/pain-assessment-and-management-for-older-patients-with-dementia-in-hospitals-an-integrative-literature-review
#9
REVIEW
I-Pei Tsai, Sarah Yeun-Sim Jeong, Sharyn Hunter
Previous studies have suggested that pain in older people with dementia is often underestimated and undertreated in acute hospitals. Undermanaged pain negatively affects a person's recovery and prolongs hospital stays. However, the issues related to pain assessment and management by nurses for this group have not been fully understood. (1) To synthesize evidence about pain assessment and management for older people with dementia in hospital settings, and (2) to discuss implications for nurses and their practice...
November 16, 2017: Pain Management Nursing: Official Journal of the American Society of Pain Management Nurses
https://www.readbyqxmd.com/read/29149797/findings-from-a-strength-based-moderate-intensity-exercise-interventions-for-individuals-with-dementia-innovative-practice
#10
Nicole Dawson, Hayden Gerhart, Katherine S Judge
Limited evidence exists regarding exercise interventions with individuals with dementia, which is often due to heterogeneity of methodology and outcomes being assessed. This led to the development and evaluation of a moderate-intensity home-based functional exercise program guided by theories from exercise science and the Strength-Based Approach. Data indicated excellent treatment adherence (99.04%) along with high levels of acceptability and feasibility in this sample (age 76.63 years (9.84); Mini Mental State Exam 18...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29149790/impressions-of-using-the-cohen-mansfield-agitation-inventory-as-an-outcome-measure-lessons-learnt-for-future-clinical-researchers-innovative-practice
#11
Lindsey Brett, Victoria Traynor, Shahla Meedya, Paul Stapley
The Cohen-Mansfield Agitation Inventory was a tool originally developed for use in research to measure agitation and subsequently used in clinical settings. It was the primary outcome measure for a randomised controlled trial which evaluated the effects and feasibility of a physiotherapist-led physical exercise intervention on agitation and physical performance of individuals living with dementia in nursing homes. The study produced weak results in regards to the Cohen-Mansfield Agitation Inventory due to small sample size and perceived issues with the use of the Cohen-Mansfield Agitation Inventory...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29149787/the-role-of-the-home-environment-in-dementia-care-and-support-systematic-review-of-qualitative-research
#12
Dia Soilemezi, Amy Drahota, John Crossland, Rebecca Stores
Background The domestic home is the preferred site for care provision for people with dementia and their families, therefore creating a dementia and caring friendly home environment is crucial. This systematic review synthesised qualitative studies to explore the role of the home environment and identify potential barriers and facilitators in home dementia care and support to inform future practice and research. Methods A systematic search in 12 databases identified international qualitative literature on perceptions and experiences of community-dwelling people with dementia, family and formal carers regarding the role of the home environment and ways to tackle daily challenges...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29145806/computer-and-telephone-delivered-interventions-to-support-caregivers-of-people-with-dementia-a-systematic-review-of-research-output-and-quality
#13
Amy Waller, Sophie Dilworth, Elise Mansfield, Rob Sanson-Fisher
BACKGROUND: To assess the scope, volume and quality of research on the acceptability, utilisation and effectiveness of telephone- and computer-delivered interventions for caregivers of people living with dementia. METHODS: Medline, EMBASE, CINAHL and Cochrane databases were searched (Jan 1990 - Dec 2016). Eligible papers were classified as data-based descriptive, measurement or intervention studies. Intervention studies were first categorised according to mode of delivery (e...
November 16, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/29145739/the-development-of-positive-psychology-outcome-measures-and-their-uses-in-dementia-research-a-systematic-review
#14
Charlotte R Stoner, Jacki Stansfeld, Martin Orrell, Aimee Spector
Positive psychology is gaining credence within dementia research but currently there is a lack of outcome measures within this area developed specifically for people with dementia. Authors have begun adopting positive psychology measures developed with other populations but there is no consensus around which are more appropriate or psychometrically robust. A systematic search identified measures used between 1998 and 2017 and an appraisal of the development procedure was undertaken using standardised criteria enabling the awarding of scores based on reporting of psychometric information...
January 1, 2017: Dementia
https://www.readbyqxmd.com/read/29145205/decline-in-search-speed-and-verbal-memory-over-26-years-of-midlife-in-a-british-birth-cohort
#15
Daniel Davis, Rebecca Bendayan, Graciela Muniz Terrera, Rebecca Hardy, Marcus Richards, Diana Kuh
BACKGROUND: Cognitive capabilities change in later life, although their onset and rate of decline, and how they are shaped by lifetime socioeconomic position, childhood cognition and adult health status are all unclear. METHODS: From the Medical Research Council National Survey of Health and Development, we analysed 3,192 participants undergoing one or more cognitive assessments at ages 43, 53, 60-64 and 69. Linear mixed models described cognitive trajectories, adjusting for factors across the life course...
November 16, 2017: Neuroepidemiology
https://www.readbyqxmd.com/read/29145189/rem-sleep-behavior-disorder
#16
Claudio L Bassetti, Panagiotis Bargiotas
Rapid eye movement sleep behavior disorder (RBD) is a brain disorder, characterized by the dream enactment during rapid eye movement (REM) sleep due to a lack of physiologic muscle atonia and increased muscle twitching. Schenk was the first to describe this disorder in 1986; however, few authors reported in the 1970-1980s loss of physiological muscle atonia combined with dream enactment in the course of brainstem disorders and as a consequence of alcoholism and antidepressant treatment. RBD affects less than 1% of the adult population, but can be found in up to 25-50% of neurodegenerative disorders including Parkinson's disease, multisystem atrophy, and dementia with Lewy body...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29143695/an-overview-of-systematic-reviews-of-pharmacological-and-non-pharmacological-interventions-for-the-treatment-of-behavioral-and-psychological-symptoms-of-dementia
#17
Suzanne M Dyer, Stephanie L Harrison, Kate Laver, Craig Whitehead, Maria Crotty
BACKGROUND: This systematic overview reports findings from systematic reviews of randomized controlled trials of pharmacological and non-pharmacological interventions for behavioural and psychological symptoms of dementia (BPSD). METHODS: The Cochrane Database of Systematic Reviews, DARE, Medline, EMBASE, and PsycINFO were searched to September 2015. RESULTS: Fifteen systematic reviews of eighteen different interventions were included. A significant improvement in BPSD was seen with: functional analysis-based interventions (GRADE quality of evidence moderate; standardized mean difference (SMD) -0...
November 16, 2017: International Psychogeriatrics
https://www.readbyqxmd.com/read/29143692/non-pharmacological-interventions-for-lewy-body-dementia-a-systematic-review
#18
Michael H Connors, Lena Quinto, Ian McKeith, Henry Brodaty, Louise Allan, Claire Bamford, Alan Thomas, John-Paul Taylor, John T O'Brien
Lewy body dementia (consisting of dementia with Lewy bodies and Parkinson's disease dementia) is a common neurodegenerative disease characterised by visual hallucinations, fluctuating attention, motor disturbances, falls, and sensitivity to antipsychotics. This combination of features presents challenges for pharmacological management. Given this, we sought to review evidence for non-pharmacological interventions with patients with Lewy body dementia and their carers. Bibliographic databases were searched using a wide range of search terms and no restrictions were placed on study design, language, or clinical setting...
November 16, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/29143483/the-impact-of-mental-health-comorbidities-on-adherence-to-buprenorphine-a-claims-based-analysis
#19
Megan Litz, Douglas Leslie
BACKGROUND AND OBJECTIVES: Previous research has been inconclusive about whether opioid-dependent patients with psychiatric comorbidities have shorter treatment retention and higher relapse rates. This study aims to evaluate the impact of mental health comorbidities on adherence to buprenorphine using a large, national health insurance claims data base. METHODS: We used MarketScan® data from 2012 to 2014 to perform this analysis. Inclusion criteria included all patients with an opioid use disorder-related ICD-9 code who had been prescribed buprenorphine (n = 2947)...
November 16, 2017: American Journal on Addictions
https://www.readbyqxmd.com/read/29143463/advances-in-chronic-cerebral-circulation-insufficiency
#20
REVIEW
Da Zhou, Ran Meng, Si-Jie Li, Jing-Yuan Ya, Jia-Yue Ding, Shu-Ling Shang, Yu-Chuan Ding, Xun-Ming Ji
Chronic cerebral circulation insufficiency (CCCI) may not be an independent disease; rather, it is a pervasive state of long-term cerebral blood flow insufficiency caused by a variety of etiologies, and considered to be associated with either occurrence or recurrence of ischemic stroke, vascular cognitive impairment, and development of vascular dementia, resulting in disability and mortality worldwide. This review summarizes the features and recent progress of CCCI, mainly focusing on epidemiology, experimental research, pathophysiology, etiology, clinical manifestations, imaging presentation, diagnosis, and potential therapeutic regimens...
November 15, 2017: CNS Neuroscience & Therapeutics
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