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Dementia research

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https://www.readbyqxmd.com/read/28433550/evaluation-of-a-telephone-delivered-community-based-collaborative-care-management-program-for-caregivers-of-older-adults-with-dementia
#1
Shahrzad Mavandadi, Laura O Wray, Suzanne DiFilippo, Joel Streim, David Oslin
OBJECTIVES: To evaluate whether a community-based, telephone-delivered, brief patient/caregiver-centered collaborative dementia care management intervention is associated with improved caregiver and care recipient (CR) outcomes. DESIGN: Longitudinal program evaluation of a clinical intervention; assessments at baseline and 3- and 6-month follow-up. SETTING: General community. PARTICIPANTS: Caregivers (N = 440) of older, community-dwelling, low-income CRs prescribed a psychotropic medication by a primary care provider who met criteria for dementia and were enrolled in the SUpporting Seniors Receiving Treatment And INtervention (SUSTAIN) program for older adults...
March 27, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28432419/-driving-and-dementia-an-issue-for-general-practice
#2
REVIEW
Verena Leve, Katharina Ilse, Marie Ufert, Stefan Wilm, Michael Pentzek
BACKGROUND: With most forms of dementia, the risk of road traffic accidents increases with disease progression. Addressing the issue of fitness to drive at an early stage can help to reduce driving-related risks and simultaneously preserve mobility. General practitioners (GPs) are central contact persons for dementia patients and their relatives in medical and psychosocial matters, and also play a key role in addressing the issue of driving safety. OBJECTIVE: Identification of relevant aspects of managing fitness to drive in dementia, as well as of support requirements for German general practice...
April 21, 2017: Zeitschrift Für Gerontologie und Geriatrie
https://www.readbyqxmd.com/read/28431539/pain-intervention-for-people-with-dementia-in-nursing-homes-pid-study-protocol-for-a-quasi-experimental-nurse-intervention
#3
Andrea Koppitz, Georg Bosshard, Geneviève Blanc, Hannele Hediger, Sheila Payne, Thomas Volken
BACKGROUND: It is estimated that 19 to 83% of people with dementia suffer from pain that is inadequately treated in the last months of life. A large number of healthcare workers who care for these people in nursing homes lack appropriate expertise and may therefore not always recognise, assess and treat pain in those with dementia who have complex problems on time, properly and efficiently. The aim of this intervention trial is to identify care needs of people with dementia suffering from pain living in a nursing home...
April 21, 2017: BMC Palliative Care
https://www.readbyqxmd.com/read/28431511/validation-of-the-short-version-of-the-10-66-dementia-diagnosis-in-multiethnic-asian-older-adults-in-singapore
#4
Edimansyah Abdin, Janhavi Ajit Vaingankar, Louisa Picco, Boon Yiang Chua, Martin Prince, Siow Ann Chong, Mythily Subramaniam
BACKGROUND: To validate the short version of the 10/66 dementia diagnosis against the standard version of the 10/66 dementia diagnosis and clinical diagnosis and examine concurrent validity with the World Health Organisation Disability Assessment schedule and care needs in a multiethnic Asian older adult population in Singapore. METHODS: Data from the Well-being of the Singapore Elderly study, a nationally representative survey of the older Singapore Resident population aged 60 years and above was used...
April 21, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28429825/validation-of-the-mds-research-criteria-for-prodromal-parkinson-s-disease-longitudinal-assessment-in-a-rem-sleep-behavior-disorder-rbd-cohort
#5
Seyed-Mohammad Fereshtehnejad, Jacques Y Montplaisir, Amelie Pelletier, Jean-François Gagnon, Daniela Berg, Ronald B Postuma
BACKGROUND: Recently, the International Parkinson and Movement Disorder Society introduced the prodromal criteria for PD. Objectives Our study aimed to examine diagnostic accuracy of the criteria as well as the independence of prodromal markers to predict conversion to PD or dementia with Lewy bodies. METHODS: This prospective cohort study was performed on 121 individuals with rapid eye movement sleep behavior disorder who were followed annually for 1 to 12 years...
April 21, 2017: Movement Disorders: Official Journal of the Movement Disorder Society
https://www.readbyqxmd.com/read/28429562/predictors-of-the-health-related-quality-of-life-of-chinese-people-with-major-neurocognitive-disorders-and-their-caregivers-the-roles-of-self-esteem-and-caregiver-s-burden
#6
Daniel Kim-Wan Young, Petrus Yat-Nam Ng, Timothy Kwok
AIM: The present research study aimed to identify and compare the clinical and non-clinical factors that predict the self-reported and proxy-reported health-related quality of life (HRQoL) of people with major neurocognitive disorder (PwND) who are living at home in a Chinese society. METHODS: A total of 57 Chinese PwND-family caregiver dyads that were using the services of local senior centers were recruited through a cross-sectional survey with convenience sampling...
April 20, 2017: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/28427333/the-experiences-of-physiotherapists-treating-people-with-dementia-who-fracture-their-hip
#7
A J Hall, R Watkins, I A Lang, R Endacott, V A Goodwin
BACKGROUND: It is estimated that people with dementia are approximately three times more likely to fracture their hip than sex and age matched controls. A report by the Chartered Society of Physiotherapy found that this population have poor access to rehabilitation as inpatients and in the community. A recent scoping review found a paucity of research in this area, indeed there has been no qualitative research undertaken with physiotherapists. In order to address this evidence gap, the aim of this current study was to explore the experiences of physiotherapists treating this population...
April 20, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28426891/experiences-of-nurses-with-the-care-of-patients-with-dementia-in-acute-hospitals-a-secondary-analysis
#8
Christiane Pinkert, Eva Faul, Susi Saxer, Melanie Burgstaller, Doris Kamleitner, Hanna Mayer
AIM AND OBJECTIVES: The aim was to describe nurses' experiences in caring for people with dementia (PwD) in acute hospital settings. BACKGROUND: Recent research suggests that nurses' experience in caring for PwD in acute hospitals is characterized by frustration, overall job dissatisfaction and feelings of powerlessness and guilt. Despite a growing body of knowledge concerning the care of PwD in acute care settings, it remains unclear how nurses in acute hospitals provide care for PwD and what general conditions characterize the nursing care provided to these patients...
April 20, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28424797/magnetoencephalography-as-a-tool-in-psychiatric-research-current-status-and-perspective
#9
REVIEW
Peter J Uhlhaas, Peter Liddle, David E J Linden, Anna C Nobre, Krish D Singh, Joachim Gross
The application of neuroimaging to provide mechanistic insights into circuit dysfunctions in major psychiatric conditions and the development of biomarkers are core challenges in current psychiatric research. We propose that recent technological and analytic advances in magnetoencephalography (MEG), a technique that allows measurement of neuronal events directly and noninvasively with millisecond resolution, provides novel opportunities to address these fundamental questions. Because of its potential in delineating normal and abnormal brain dynamics, we propose that MEG provides a crucial tool to advance our understanding of pathophysiological mechanisms of major neuropsychiatric conditions, such as schizophrenia, autism spectrum disorders, and the dementias...
April 2017: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
https://www.readbyqxmd.com/read/28424611/modafinil-induced-changes-in-functional-connectivity-in-the-cortex-and-cerebellum-of-healthy-elderly-subjects
#10
Miriam Punzi, Tommaso Gili, Laura Petrosini, Carlo Caltagirone, Gianfranco Spalletta, Stefano L Sensi
In the past few years, cognitive enhancing drugs (CEDs) have gained growing interest and the focus of investigations aimed at exploring their use to potentiate the cognitive performances of healthy individuals. Most of this exploratory CED-related research has been performed on young adults. However, CEDs may also help to maintain optimal brain functioning or compensate for subtle and or subclinical deficits associated with brain aging or early-stage dementia. In this study, we assessed effects on resting state brain activity in a group of healthy elderly subjects undergoing acute administration of modafinil, a wakefulness-promoting agent...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28424374/mechanisms-of-vascular-disease-in-dementia-what-does-industry-want-to-know
#11
EDITORIAL
Paul B Wren, Derek Hill, Andrew Lockhart
Despite recent advances in basic and clinical science, dementia remains an area of high unmet medical need. The role of cerebrovascular mechanisms in the pathogenesis and progression of cognitive and functional impairment in dementia is being revived. In order to facilitate the development of therapeutic approaches, it is critical that a number of fundamental elements are integrated into research strategies investigating cerebrovascular pathologies as these will maximize the opportunity of bringing medicines to patients in a timely manner...
May 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28423852/using-the-mrc-framework-for-complex-interventions-to-develop-clinical-decision-support-a-case-study
#12
Dawn Dowding, Valentina Lichtner, S José Closs
The Medical Research Council (MRC) framework for complex interventions provides useful guidance to assist with the development and evaluation of health technology interventions such as decision support. In this paper we briefly summarise a project that focused on designing a decision support intervention to assist with the recognition, assessment and management of pain in patients with dementia in an acute hospital setting. We reflect on our experience of using the MRC framework to guide our study design, and highlight the importance of considering decision support interventions as complex interventions...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28418899/an-exploration-of-the-role-of-a-fish-oriented-diet-in-cognitive-decline-a-systematic-review-of-the-literature
#13
REVIEW
Ling-Feng Zeng, Ye Cao, Wei-Xiong Liang, Wen-Hu Bao, Jian-Ke Pan, Qi Wang, Jun Liu, Hao-Dong Liang, Hui Xie, Yan-Ting Chai, Zi-Tong Guan, Qian Cao, Xiao-Yan Li, Lei Yang, Wei-Hua Xu, Sui-Qing Mi, Ning-Sheng Wang
Epidemiological studies have presented inconsistent evidence of the correlation between a fish-oriented dietary intake (FDI) and the risk of cognitive decline. To address these controversies, we performed this systematic review of prospective studies published in December 2016 and earlier using PubMed, Embase, and Web of Science. Two independent researchers conducted the eligibility assessment and data extraction; all discrepancies were solved by discussion with a third researcher. The pooled relative risks (RRs) focused on the incidence of events were estimated with 95% confidence intervals (CIs)...
March 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/28418586/simulated-presence-therapy-for-dementia
#14
REVIEW
Iosief Abraha, Joseph M Rimland, Isabel Lozano-Montoya, Giuseppina Dell'Aquila, Manuel Vélez-Díaz-Pallarés, Fabiana M Trotta, Alfonso J Cruz-Jentoft, Antonio Cherubini
BACKGROUND: Dementia is a common and serious neuropsychiatric syndrome, characterised by progressive cognitive and functional decline. The majority of people with dementia develop behavioural disturbances, also known as behavioural and psychological symptoms of dementia (BPSD). Several non-pharmacological interventions have been evaluated to treat BPSD in people with dementia. Simulated presence therapy (SPT), an intervention that uses video or audiotape recordings of family members played to the person with dementia, is a possible approach to treat BPSD...
April 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28418180/-little-things-matter-exploring-the-perspectives-of-patients-with-dementia-about-the-hospital-environment
#15
Lillian Hung, Alison Phinney, Habib Chaudhury, Paddy Rodney, Jenifer Tabamo, Doris Bohl
BACKGROUND: Recognising demographic changes and importance of the environment in influencing the care experience of patients with dementia, there is a need for developing the knowledge base to improve hospital environments. Involving patients in the development of the hospital environment can be a way to create more responsive services. To date, few studies have involved the direct voice of patients with dementia about their experiences of the hospital environment. DESIGN AND METHOD: Using an action research approach, we worked with patients with dementia and a team of interdisciplinary staff on a medical unit to improve dementia care...
April 18, 2017: International Journal of Older People Nursing
https://www.readbyqxmd.com/read/28418163/psychometric-properties-of-the-apathy-evaluation-scale-in-patients-with-parkinson-s-disease
#16
Ulrike Lueken, Ricarda Evens, Monika Balzer-Geldsetzer, Simon Baudrexel, Richard Dodel, Susanne Gräber-Sultan, Rüdiger Hilker-Roggendorf, Elke Kalbe, Oliver Kaut, Brit Mollenhauer, Kathrin Reetz, Eva Schäffer, Nele Schmidt, Jörg B Schulz, Annika Spottke, Karsten Witt, Katharina Linse, Alexander Storch, Oliver Riedel
Parkinson's disease (PD) frequently entails non-motor symptoms, worsening the course of the disease. Apathy is one of the core neuropsychiatric symptoms that has been investigated in recent years; research is however hampered by the limited availability of well-evaluated apathy scales for these patients. We evaluated the psychometric properties of the Apathy Evaluation Scale (AES) in a sample of PD patients. Psychometric properties, convergent and discriminant validity and sensitivity/specificity were evaluated in patients with (n = 582) or without dementia/depression (n = 339)...
April 18, 2017: International Journal of Methods in Psychiatric Research
https://www.readbyqxmd.com/read/28418065/vitamin-e-for-alzheimer-s-dementia-and-mild-cognitive-impairment
#17
REVIEW
Nicolas Farina, David Llewellyn, Mokhtar Gad El Kareem Nasr Isaac, Naji Tabet
BACKGROUND: Vitamin E occurs naturally in the diet. It has several biological activities, including functioning as an antioxidant to scavenge toxic free radicals. Evidence that free radicals may contribute to the pathological processes behind cognitive impairment has led to interest in the use of vitamin E supplements to treat mild cognitive impairment (MCI) and Alzheimer's disease (AD). This is an update of a Cochrane Review first published in 2000, and previously updated in 2006 and 2012...
April 18, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28417674/international-summit-consensus-statement-intellectual-disability-inclusion-in-national-dementia-plans
#18
Karen Watchman, Matthew P Janicki, Michael Splaine, Frode K Larsen, Tiziano Gomiero, Ronald Lucchino
The World Health Organization (WHO) has called for the development and adoption of national plans or strategies to guide public policy and set goals for services, supports, and research related to dementia. It called for distinct populations to be included within national plans, including adults with intellectual disability (ID). Inclusion of this group is important as having Down's syndrome is a significant risk factor for early-onset dementia. Adults with other ID may have specific needs for dementia-related care that, if unmet, can lead to diminished quality of old age...
January 1, 2017: American Journal of Alzheimer's Disease and Other Dementias
https://www.readbyqxmd.com/read/28417268/sexual-behavior-among-persons-with-cognitive-impairments
#19
REVIEW
Robyn P Thom, Albert J Grudzinskas, Fabian M Saleh
Although the cognitively impaired are frequently included in heterogeneous studies of problematic sexual behavior, the epidemiology, etiology, and approach to assessment and treatment of persons with dementia and intellectual disability are distinct from those of the general population. The incidence of inappropriate sexual behavior among the intellectually disabled is 15-33%; however, the nature tends to be more socially inappropriate than with violative intent. Limited sociosexual education is a large contributor, and better addressing this area offers a target for prevention and treatment...
May 2017: Current Psychiatry Reports
https://www.readbyqxmd.com/read/28416129/increase-in-parkinson-s-disease-related-mortality-among-males-in-northern-italy
#20
Ugo Fedeli, Elena Schievano
BACKGROUND: According to standard mortality statistics based on the underlying cause of death (UCOD), mortality from Parkinson's disease (PD) is increasing in most European countries. However, mortality trends are better investigated taking into account all the diseases reported in the death certificate (multiple causes of death approach, MCOD). METHODS: All deaths of residents in the Veneto Region (Northern Italy) aged≥45 years with any mention of PD were extracted from 2008 to 2015...
April 12, 2017: Parkinsonism & related Disorders
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