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Jianping Hu, Yingqing Wang, Yanlian Li, Danyan Cao, Lin Xu, ShanShan Song, Mohammadali Soleimani Damaneh, Jian Li, Yuelei Chen, Xin Wang, Lin Chen, Jingkang Shen, Zehong Miao, Bing Xiong
Recently, several kinase inhibitors were found to also inhibit bromodomains, providing a new strategy for the discovery of bromodomain inhibitors. Along this line, starting from PLK1-BRD4 dual inhibitor BI-2536, we discovered a new series of dihydroquinoxalin-2(1H)-one with aniline and indoline WPF binders as selective BRD4 inhibitors. They showed better BRD4-BD1 potency and negligible PLK1 kinase activity comparing with BI-2536. Additionally, dihydroquinoxalin-2(1H)-ones containing indoline group showed profound activities in molecular and cellular based assays...
February 24, 2018: European Journal of Medicinal Chemistry
Seyyed Javad Mousavi, Mehdi Parvini, Mohsen Ghorbani
In the present study, new generation of silica-based mesoporous adsorbents were introduced for the removal of heavy metals with the aim of developing new adsorption technologies in water treatment. The magnetic nanoadsorbent, prepared by modification of SBA-15 with [3-(2-Aminoethylamino) propyl] trimethoxysilane (AEAPTMS)-functionalized chitosan, was applied for the removal of Zn2+ from aqueous solution. The synthesized Fe2 O3 @SBA-15-CS-AEAPTMS nanoadsorbent was thoroughly characterized using XRD, TEM, FTIR and BET analysis...
May 15, 2018: Carbohydrate Polymers
Suli Zhi, Liang Tian, Nan Li, Keqiang Zhang
The MnO2 -mullite-cordierite composite particle (MnO2 -MCP) was prepared and firstly was applied as catalyst with sodium hypochlorite (NaOCl) as oxidant in heterogeneous Fenton-like system for methylene blue (MB) decolorization. The MnO2 -MCP was characterized by XRD, SEM, EDS and BET analysis. The decolorization efficiencies of MB/MnO2 -MCP, MB/NaClO, (MB after filtrating MnO2 -MCP)/NaClO and MB/MnO2 -MCP/NaClO were compared, which confirmed the interaction ability between MnO2 -MCP and NaClO. After evaluating the role of adsorption of MB by MnO2 -MCP, the catalytic oxidation effects of MnO2 -MCP with NaClO on MB were exploited...
March 2, 2018: Journal of Environmental Management
Naghmeh Sadat Mirbagheri, Samad Sabbaghi
Synthetic dyes are among the most important environmental pollutants in wastewaters. Consequently, elimination of the synthetic dyes from wastewaters using non-toxic materials and eco-friendly technologies has been of considerable interests. In this study, magnetically separable Ti-doped γ-Fe2 O3 photocatalysts were synthesized for the removal of methylene blue (MB) from a dye-contaminated aqueous solution (as a model of dye-polluted wastewaters). Compared to the pristine γ-Fe2 O3 , the 1.78 v% Ti-doped γ-Fe2 O3 significantly increased the adsorption of MB by 57% in the dark condition as a result of the improved BET surface area in this photocatalyst...
February 22, 2018: Journal of Environmental Management
Yue Meng, Xiaofeng Zhang, Guoxiang Pan, Shengjie Xia, Zheming Ni
A novel hybrid layered material-Schiff Base-Zinc Complexes intercalated ZnCr-LDHs-supported ZnO-was synthesized by one-step coprecipitation method and characterized by XRD, UV-vis DRS, SEM, TEM, BET, ICP-AES and XPS analysis. The influences of the three Zn components (intercalated between the layers, supported on the surface, distributed in the host layers of the layered material) on the crystallinity and the photocatalytic activity of ZnO/ZnCr-SalenZn-LDHs for Rhodamine B (RhB) degradation were studied in detail by orthogonal design...
February 11, 2018: Journal of Hazardous Materials
Aditti S Barge, Prakash D Vaidya
Wet air oxidation (WAO) is a candidate technique for the effective treatment of spent caustic wastewater. In this work, cresols were chosen as model compounds to represent cresylic spent caustic wash. Graphene oxide (GO) is a promising catalyst as well as support for the wet oxidation process, due to its unique structure and properties. For the first time, GO and ruthenium supported on graphene oxide (Ru/GO) were employed for WAO of cresylic isomers. The aforesaid materials were synthesized by modified Hummer's method and characterized using scanning electron microscopy (SEM), field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), Fourier transform infrared (FT-IR) spectroscopy, X-ray diffraction (XRD) and Brunauer-Emmett-Teller (BET) analysis...
February 17, 2018: Journal of Environmental Management
Narges Nobakht, Mohammad Ali Faramarzi, Abbas Shafiee, Mehdi Khoobi, Ezzat Rafiee
Iron-carboxylate (MIL-100(Fe)) and HKUST-1 (Cu3 (BTC)2 , BTC = 1,3,5-benzenetricarboxylic acid) as nanoporous metal organic framework supports were compared for immobilization of porcine pancreatic lipase (PPL). These immobilizations improved thermal, pH and operational stability of PPL compared to the soluble enzyme. Stability of MIL-100(Fe) was better than HKUST-1 as support. MIL-100(Fe) encapsulated Keggin phosphotungstic acid H3 PW12 O40 (PW) (PW@MIL-100(Fe)) was synthesized to develop novel enzyme immobilized system and characterized by Fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FE-SEM), Brunauer-Emmett-Teller (BET), X-ray diffraction (XRD) and Barrett Joyner Halenda (BJH) analysis...
February 15, 2018: International Journal of Biological Macromolecules
Dipendu Saha, Bryan Taylor, Nicole Alexander, Daniel F Joyce, Gabriela I Faux, Yiting Lin, Vladimir Shteyn, Gerassimos Orkoulas
Highly microporous carbons have been synthesized from four types of agro-wastes of lignin, walnut shells, orange peels and apricot seeds by one-step carbonization/activation with potassium hydroxide (KOH) in varying ratios. The resultant carbons demonstrated BET specific surface areas of 727-2254 m 2 /g, and total pore volumes 0.34-1.14 cm 3 /g. These are higher than the majority of agro-waste derived carbons reported in the literature. For all the carbons, CO 2 adsorption at 298 K was higher than SF 6 followed by N 2 suggesting a possible separation of CO 2 and SF 6 from N 2 ...
February 6, 2018: Bioresource Technology
Arulselvan Devarajan, Sivakumar Thiripuranthagan, Ramakrishnan Radhakrishnan, Sakthivel Kumaravel
Drastic increase in green house gases due to fossil fuels usage urges the mankind to look for alternative fuel resources. Biodiesel is one of the alternative fuels which attracted the attention of many researchers. In recent years, bio-diesel drags much attention as an alternative clean fuel. Glycerol is an unavoidable byproduct in the transesterification process of vegetable oils into bio diesel and therefore market is flooded with glycerol. So it is high time to find ways of utilizing the abundant glycerol into value added products...
July 1, 2018: Journal of Nanoscience and Nanotechnology
Shuangzhen Guo, Jian Zhang, Xianlong Li, Fan Zhang, Xixi Zhu
A novel core-shell bio-adsorbent was fabricated by using biological materials for removing methyl orange (MO) from aqueous solution. The structure characteristics results of scanning electron microscopy (SEM), Fourier transform infrared spectrometry (FT-IR), thermo-gravimetric analysis (TGA), vibrating sample magnetometer (VSM), and Brunauer-Emmett-Teller (BET) shows that Fe3O4-CS-L has been successfully prepared. The effects of contact time, pH, temperature and initial concentration were explored. The results suggested pH was a negligible factor in adsorption progress...
February 2018: Water Science and Technology: a Journal of the International Association on Water Pollution Research
Cheng Bin He, Kuan Lun Pan, Moo Been Chang
Three perovskite-type catalysts including LaMnO3, La0.8Ce0.2MnO3, and La0.8Ce0.2 Mn0.8Ni0.2O3 are prepared using citric acid sol-gel method and evaluated as catalyst for the oxidation of trichloroethylene (TCE) in air with temperature ranging from 100 to 600 °C. The physicochemical properties of three perovskite-type catalysts were characterized by SEM, EDS, XRD, BET, and XPS to investigate the relationship with catalytic activities. The results show that the removal efficiency of TCE achieved with La0.8Ce0...
February 10, 2018: Environmental Science and Pollution Research International
Shiva Navazani, Ali Shokuhfar, Mostafa Hassanisadi, Mojtaba Askarieh, Aldo Di Carlo, Antonio Agresti
Stannic oxide nanoparticles and various compositions of SnO2@rGO (reduced graphene oxide) nanohybrids were synthesized by a facile hydrothermal method and utilized as chemiresistive methane gas sensors. To characterize the synthesized nanohybrids, BET (Brunauer-Emmett-Teller), XRD, FESEM, TEM, FTIR, and Raman techniques were used. Sensing elements were tested using a U-tube flow chamber with temperature control. To obtain the best sensor performance, i.e., the highest signal and the fastest response and recovery times, the sensing element composition, operating temperature, and gas flow rate were optimized...
May 1, 2018: Talanta
Bharath Velaga, Pradeep P Shanbogh, Diptikanta Swain, Chandrabhas Narayana, Nalini G Sundaram
SnO2 -Ta2 O5 nanocomposite was synthesised by a facile co-precipitation method and further calcined to obtain crystalline powder. Phase formation, morphology, bandgap and photo-catalytic properties were analysed using powder X-ray diffraction, Scanning electron microscopy, UV-Vis diffused reflectance spectroscopy, BET surface area and Raman spectroscopy respectively. Effect of calcination temperature on the crystallinity of the composite was studied. The as prepared samples of SnO2 , Ta2 O5 and SnO2 -10wt%Ta2 O5 composite as well as the calcined composite sample were tested for photocatalytic activity for methylene blue dye degradation under visible light...
February 8, 2018: Photochemistry and Photobiology
Javeed Mahmood, Seok-Jin Kim, Hyuk-Jun Noh, Sun-Min Jung, Feng Li, Jeong-Min Seo, Jong-Beom Baek
We report a three-dimensional (3D) cage-like organic network (3D-CON) structure synthesized via the straightforward condensation of building blocks designed with gas adsorption properties. The 3D-CON can be prepared using an easy but powerful route, which is essential for commercial scale-up. The resulting fused aromatic 3D-CON exhibited a high Brunauer-Emmett-Teller (BET) specific surface area of up to 2247 m2 g1. More importantly, the 3D-CON displayed outstanding low pressure hydrogen (H2, 2.64 wt%, 1...
February 2, 2018: Angewandte Chemie
R Uotila, A K Kukkonen, W M Blom, B Remington, J Westerhout, A S Pelkonen, M J Mäkelä
BACKGROUND: Nut allergy varies from pollen cross-allergy, to primary severe allergy with life-threatening symptoms. The screening of IgE antibodies to a wide spectrum of allergens, including species-specific and cross-reactive allergens, is made possible via microarray analysis. OBJECTIVE: We sought to study the association of variable IgE sensitization profiles to clinical response in peanut-challenged children and adolescents in a birch-endemic region. In addition, we studied the avoidance of tree nuts and species-specific sensitizations...
January 29, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Ningning Liu, Yunhai Wu, Haitao Sha
The synthesis process of Fe-Al hydroxides coated with ethylenediaminetetraacetic acid (EDTA)-cross-linked β-cyclodextrin polymer (FA-ECD) and its utilization in the adsorption of methylene blue (MB) were investigated. The FA-ECD before and after adsorption was characterized by scanning electron microscopy (SEM), Brunauer-Emmet-Teller (BET) analysis, Fourier-transform infrared (FTIR) spectroscopy, thermogravimetric (TG) analysis, and X-ray diffraction (XRD). In addition, the EDTA and β-cyclodextrin contents were determined quantitatively...
January 20, 2018: Journal of Colloid and Interface Science
Lianke Zhang, Xinyu Liu, Xuemin Huang, Weida Wang, Peng Sun, Yumei Li
This study evaluated the removal of Pb2+ in aqueous solution using Fe-Mn binary oxides-loaded biochar (BFMs). The characteristics of BFM were obtained using scanning electron microscopy(SEM), energy dispersive spectrometer(EDS), BET, X-ray diffraction(XRD), and X-ray photoelectron spectroscopy(XPS). The effects of pH, adsorbent dose, contact time, initial Pb2+ concentration, and temperature in the batch sorption experiments were investigated. Adsorption was evaluated by adsorption kinetics, isotherm models, and thermodynamics...
January 24, 2018: Environmental Technology
Mengjie Pu, Zeyu Guan, Yongwen Ma, Jinquan Wan, Yan Wang, Mark L Brusseau, Haiyuan Chi
A series of MIL-53(Fe) materials were synthesized using a solvothermal method under different temperature and time conditions and were used as catalysts to activate persulfate and degrade Orange G (OG). Influences of the above conditions on the crystal structure and catalytic behavior were investigated. Degradation of OG under different conditions was evaluated, and the possible activation mechanism was speculated. The results indicate that high synthesis temperature (larger than 170 °C) leads to poor crystallinity and low catalytic activity, while MIL-53(Fe) cannot fully develop at low temperature (100 or 120 °C)...
January 5, 2018: Applied Catalysis. A, General
Craig Ferguson, Jonathan Lewin
A short cut review was carried out to establish whether chemical thromboprophylaxis was a safe early intervention in patients with solid organ injury that is being managed non-operatively. Eight papers presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these papers are tabulated. It is concluded that there is inadequate evidence assessing safety of low molecular weight heparin (LMWH) within 24 hours of trauma...
February 2018: Emergency Medicine Journal: EMJ
Joshua Badour, Matt Singh, Jeffrey Jones
A short cut review was carried out to establish whether the addition of irrigation of the abscess cavity improved outcomes after incision and drainage of a cutaneous abscess. One paper presented the best evidence to answer the clinical question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of this paper are tabulated. It is concluded that in adult patients with cutaneous abscesses routine irrigation during incision and drainage does not improve clinical outcomes...
February 2018: Emergency Medicine Journal: EMJ
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