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Lingzhi Hu, Junjie Chen, Xiaoxia Yang, Shelton D Caruthers, Gregory M Lanza, Samuel A Wickline
We present a novel blood flow-enhanced-saturation-recovery (BESR) sequence, which allows rapid in vivo T1 measurement of blood for both (1)H and (19)F nuclei. BESR sequence is achieved by combining homogeneous spin preparation and time-of-flight image acquisition and therefore preserves high time efficiency and signal-to-noise ratio for (19)F imaging of circulating perfluorocarbon nanoparticles comprising a perfluoro-15-crown-5-ether core and a lipid monolayer (nominal size = 250 nm). The consistency and accuracy of the BESR sequence for measuring T1 of blood was validated experimentally...
July 2013: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
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