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Dengue AND Papaya

Ambika R Keramagi, Sinosh Skariyachan
The current study aimed to assess the binding potential of herbal lead molecules against the prioritized molecular targets of chikungunya virus (CHIKV) and dengue virus (DENV) by computational virtual screening and suggests a novel therapeutic intervention. Based on the metabolic pathway analysis and virulent functions, the non-structural and envelop proteins present in CHIKV and DENV were identified as putative drug targets. The structures of the protein not available in their native forms were computationally predicted by homology modeling...
June 2018: 3 Biotech
Rajkuberan Chandrasekaran, Prabukumar Seetharaman, Muthukumar Krishnan, Sathishkumar Gnanasekar, Sivaramakrishnan Sivaperumal
This study manifests the larvicidal efficacy of Carica papaya latex extract and silver nanoparticles (CPAgNPs) synthesized using latex, against developing immature juveniles of Aedes aegypti and Culex quinquefasciatus . Briefly, the latex was collected and fractioned with different solvents such as chloroform, methanol and aqueously. The obtained crude extracts were subjected to larvicidal activity in the dose-dependent method. After 24 h, the mortality rate was calculated and statistically analyzed. From the results, it was demonstrated that the chloroform extract displayed prominent activity in IInd and IIIrd instar larvae of A...
February 2018: 3 Biotech
Varisha Anjum, Poonam Arora, Shahid Husain Ansari, Abul Kalam Najmi, Sayeed Ahmad
CONTEXT: Carica papaya Linn. (Caricaceae) leaf (CPL) juice has long been traditionally used in ethnomedicine for dengue fever. OBJECTIVE: The study examines the effects of standardized CPL aqueous extract (SCPLE) on platelet count, extramedullary haematopoiesis (EMH), and immunomodulation in cyclophosphamide (CP)-induced animal model of thrombocytopenia. MATERIALS AND METHODS: The extract was analyzed for myricetin, caffeic acid, trans-ferulic acid, and kaempferol using HPTLC for standardization followed by UPLC-qTOF/MS fingerprinting for metabolite signature...
December 2017: Pharmaceutical Biology
Jayant Pai Dhungat, Geeta Gore
No abstract text is available yet for this article.
December 2016: Journal of the Association of Physicians of India
Jaykaran Charan, Deepak Saxena, Jagdish Prasad Goyal, Sandul Yasobant
BACKGROUND: Dengue is an infectious disease associated with high mortality and morbidity. Being a viral disease, there is no specific drug available for treatment. There are some reports that Carica papaya leaf extract may improve the clinical condition of dengue patients; however, to support this, at present, there is no systematically searched and synthesized evidence available. OBJECTIVES: This systematic review and meta-analysis was designed to search the available evidence related to the efficacy and safety of C...
October 2016: International Journal of Applied and Basic Medical Research
Ajeet Kumar Gadhwal, B S Ankit, Chitresh Chahar, Pankaj Tantia, P Sirohi, R P Agrawal
OBJECTIVE: Thrombocytopenia in dengue fever is a common and serious complication. However, no specific treatment is available for dengue fever induced thrombocytopenia. In few countries (Pakistan, Malaysia, Sri Lanka and other Asian countries) the leaf extract of Carica papaya has been effectively used for thrombocytopenia. So, the study is planned to access effect of Carica papaya leaf extract on platelet count in dengue fever patients. METHODS: All participants were randomised into two groups, study group and control group; the study group was given papaya leaf extract capsule of 500 mg once daily and routine supportive treatment for consecutive five days...
June 2016: Journal of the Association of Physicians of India
Prabhu Nagnathappa Kasture, K H Nagabhushan, Arun Kumar
INTRODUCTION: Dengue is a rapidly expanding global health problem. Approximately 2.5 billion people live in dengue-risk regions with about 100 million new cases each year worldwide. The cumulative dengue diseases burden has attained an unprecedented proportion in recent times with sharp increase in the size of human population at risk. The management of dengue virus infection is essentially supportive and symptomatic and no specific treatment is available for increasing the fallen platelets, which have a significant role in causing the mortality of dengue patient...
June 2016: Journal of the Association of Physicians of India
Ghan Shyam Pangtey, Anupam Prakash, Yash Pal Munjal
No abstract text is available yet for this article.
June 2016: Journal of the Association of Physicians of India
Dharani S, C R Jayanthi
No abstract text is available yet for this article.
January 2016: Journal of the Association of Physicians of India
Reshma Mohamed Ansari
No abstract text is available yet for this article.
May 2016: Indian Journal of Pharmacology
Shobia Chinnappan, Vijayakumar Shettikothanuru Ramachandrappa, Kadhiravan Tamilarasu, Uma Maheswari Krishnan, Agiesh Kumar Balakrishna Pillai, Soundravally Rajendiran
Dengue cases were reported to undergo platelet activation and thrombocytopenia by a poorly understood mechanism. Recent studies suggested that Carica papaya leaf extract could recover the platelet count in dengue cases. However, no studies have attempted to unravel the mechanism of the plant extract in platelet recovery. Since there are no available drugs to treat dengue and considering the significance of C. papaya in dengue treatment, the current study aimed to evaluate two research questions: First one is to study if the C...
April 2016: Viral Immunology
Nazia Asghar, Syed Ali Raza Naqvi, Zaib Hussain, Nasir Rasool, Zulfiqar Ali Khan, Sohail Anjum Shahzad, Tauqir A Sherazi, Muhammad Ramzan Saeed Ashraf Janjua, Saeed Ahmad Nagra, Muhammad Zia-Ul-Haq, Hawa Ze Jaafar
BACKGROUND: Carica papaya is a well known medicinal plant used in the West and Asian countries to cope several diseases. Patients were advised to eat papaya fruit frequently during dengue fever epidemic in Pakistan by physicians. This study was conducted to establish Polyphenols, flavonoids and antioxidant potential profile of extracts of all major parts of the C. papaya with seven major solvents i.e. water, ethanol, methanol, n-butanol, dichloromethane, ethyl acetate, and n-hexane. RESULTS: TPC, TFC, antioxidant and antibacterial potential were determined using different aqueous and organic solvents in addition to the determination of trace element in leaves, pulp and peel of C...
2016: Chemistry Central Journal
Jazli Aziz, Noor Lide Abu Kassim, Noor Hayaty Abu Kasim, Nazmul Haque, Mohammad Tariqur Rahman
BACKGROUND: Use of Carica papaya leaf extracts, reported to improve thrombocyte counts in dengue patients, demands further analysis on the underlying mechanism of its thrombopoietic cytokines induction METHODS: In vitro cultures of peripheral blood leukocytes (PBL) and stem cells from human exfoliated deciduous teeth (SHED) were treated with unripe papaya pulp juice (UPJ) to evaluate its potential to induce thrombopoietic cytokines (IL-6 and SCF) RESULTS: In vitro scratch gap closure was significantly faster (p < ...
2015: BMC Complementary and Alternative Medicine
Andrea Ranzoni, Anniek den Hamer, Tomislav Karoli, Joseph Buechler, Matthew A Cooper
Fluorescent labels are widely employed in biomarker quantification and diagnostics, however they possess narrow Stokes shifts and can photobleach, limiting multiplexed detection applications and compromising sensitivity. In contrast, quantum dots do not photobleach and have much wider Stokes shifts, but a paucity of robust surface attachment chemistries for bioconjugation has limited their uptake in biomedical diagnostics. We report a novel class of biofunctional fluorescent labels based on trapping of ∼10(4) quantum dots within a core nanoparticle...
June 16, 2015: Analytical Chemistry
Viroj Wiwanitkit
No abstract text is available yet for this article.
April 2013: Ancient Science of Life
N Sarala, Ss Paknikar
Dengue is a viral disease that today affects a vast number of people in over 125 countries and is responsible for a sizable number of deaths. In the absence of an effective antiviral drug to treat the disease, various treatments are being investigated. Studies have indicated that the juice of the leaves of the Carica papaya plant from the family Caricaceae could help to increase the platelet levels in these patients. This review describes some of the published studies on this topic. The search was done independently by the two authors using PubMed, Google and the library database and included relevant articles of the last 10 years...
May 2014: Annals of Medical and Health Sciences Research
Osama Siddique, Ayesha Sundus, Mohammad Faisal Ibrahim
Dengue fever is on the rise in developing nations like India, Pakistan, Sri Lanka and Bangladesh. There is no antiviral chemotherapy or vaccine for dengue virus and management of the disease is done on supportive measures. The decline in the thrombocyte count leads to dengue haemorrhagic fever accounting for complications and mortality. Oral administration of Carica papaya leaves extract is said to have a positive impact on thrombocyte count. A 23-year-old man was administered a calculated dose for five days...
March 2014: JPMA. the Journal of the Pakistan Medical Association
P Ram Manohar
No abstract text is available yet for this article.
January 2013: Ancient Science of Life
Padmanaban Senthilvel, Pandian Lavanya, Kalavathi Murugan Kumar, Rayapadi Swetha, Parimelzaghan Anitha, Susmita Bag, Sundaramoorthy Sarveswari, Vijayaparthasarathi Vijayakumar, Sudha Ramaiah, Anand Anbarasu
UNLABELLED: Dengue virus belongs to the virus family Flaviviridae. Dengue hemorrhagic disease caused by dengue virus is a public health problem worldwide. The viral non structural 2B and 3 (NS2B-NS3) protease complex is crucial for virus replication and hence, it is considered to be a good anti-viral target. Leaf extracts from Carica papaya is generally prescribed for patients with dengue fever, but there are no scientific evidences for its anti-dengue activity; hence we intended to investigate the anti-viral activity of compounds present in the leaves of Carica papaya against dengue 2 virus (DENV-2)...
2013: Bioinformation
Soobitha Subenthiran, Tan Chwee Choon, Kee Chee Cheong, Ravindran Thayan, Mok Boon Teck, Prem Kumar Muniandy, Adlin Afzan, Noor Rain Abdullah, Zakiah Ismail
The study was conducted to investigate the platelet increasing property of Carica papaya leaves juice (CPLJ) in patients with dengue fever (DF). An open labeled randomized controlled trial was carried out on 228 patients with DF and dengue haemorrhagic fever (DHF). Approximately half the patients received the juice, for 3 consecutive days while the others remained as controls and received the standard management. Their full blood count was monitored 8 hours for 48 hours. Gene expression studies were conducted on the ALOX 12 and PTAFR genes...
2013: Evidence-based Complementary and Alternative Medicine: ECAM
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