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https://www.readbyqxmd.com/read/28927209/intraoperative-imaging-in-traumatic-peripheral-nerve-lesions-correlating-histologic-cross-sections-with-high-resolution-ultrasound
#1
S Shelby Burks, Iahn Cajigas, Jean Jose, Allan D Levi
BACKGROUND: Intraoperative ultrasound (US) has been used as a guide during surgery to better identify deep neuroanatomical structures. OBJECTIVE: To correlate histologic cross-sections from nerve samples taken at the time of surgery with axial, high-resolution US images at similar locations and validate this important tool for intraoperative guidance in nerve surgery. METHODS: Three subjects undergoing nerve repair procedures after traumatic nerve injuries were enrolled prospectively...
April 1, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/28926386/effect-of-vascular-injury-on-functional-outcome-in-knees-with-multi-ligament-injury-a-matched-cohort-analysis
#2
Thomas L Sanders, Nicholas R Johnson, Nathan M Levy, Peter A Cole, Aaron J Krych, Michael Stuart, Bruce A Levy
BACKGROUND: Multi-ligament knee injury (MLKI) associated with knee dislocation can result in vascular injury. The purpose of this study was to compare knee function after MLKI between patients with a vascular injury requiring popliteal artery bypass grafting and patients without vascular involvement. Additionally, factors associated with poor knee function in patients who had MLKI with vascular injury were evaluated. METHODS: This retrospective study identified patients with an MLKI between 1992 and 2014...
September 20, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28924115/neurological-complications-in-eosinophilic-granulomatosis-with-polyangiitis-egpa-the-roles-of-history-and-the-results-of-physical-examinations-in-the-diagnosis-of-egpa
#3
Hiroshi Oiwa, Sho Mokuda, Tomoyasu Matsubara, Masamoto Funaki, Ikuko Takeda, Takemori Yamawaki, Kazuhiko Kumagai, Eiji Sugiyama
Objective To investigate the clinical symptoms, the physical and neurological findings, and the clinical course of neurological complications in eosinophilic granulomatosis with polyangiitis (EGPA). Methods A retrospective chart review of EGPA cases managed by two referral hospitals was performed, with a focus on the neurological findings. The study analyzed the symptoms at the onset of EGPA and investigated their chronological relationship. The patient delay (the delay between the onset of symptoms and the initial consultation), and the physician delay (the delay from consultation to the initiation of therapy) were determined and compared...
September 15, 2017: Internal Medicine
https://www.readbyqxmd.com/read/28919446/increased-interferon-mediated-immunity-following-in-vitro-and-in-vivo-modafinil-treatment-on-peripheral-immune-cells
#4
Adriano Zager, Wesley Nogueira Brandão, Rafael Oliveira Margatho, Daniel Sanzio Gimenes Cruz, Jean Pierre Peron, Sergio Tufik, Monica Levy Andersen, Monica Moresco, Fabio Pizza, Giuseppe Plazzi, Birgitte Rahbek Kornum, João Palermo-Neto
The wake-promoting drug Modafinil has been used for treatment of sleep disorders, such as Narcolepsy, excessive daytime sleepiness and sleep apnea, due to its stimulant action. Despite the known effect of Modafinil on brain neurochemistry, particularly on brain dopamine system, recent evidence support an immunomodulatory role for Modafinil treatment in neuroinflammatory models. Here, we aimed to study the effects of in vitro and in vivo Modafinil treatment on activation, proliferation, cell viability, and cytokine production by immune cells in splenocytes culture from mice...
September 15, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28918684/differential-induction-of-c-fos-and-phosphorylated-erk-by-a-noxious-stimulus-after-peripheral-nerve-injury
#5
Mitsuyasu Tabata, Ryuji Terayama, Kotaro Maruhama, Seiji Iida, Tomosada Sugimoto
Induction of c-Fos and phosphorylated extracellular signal-regulated kinase (p-ERK) has been demonstrated in spinal dorsal horn neurons by noxious stimuli. In this study, we compared induction of c-Fos and p-ERK in the spinal dorsal horn after peripheral nerve injury. We examined the spinal dorsal horn for noxious heat-induced c-Fos and p-ERK protein-like immunoreactive (c-Fos- and p-ERK-IR) neuron profiles after tibial nerve injury. A large number of c-Fos- and p-ERK-IR neuron profiles were induced by noxious heat stimulation to the hindpaw in sham-operated animals...
September 18, 2017: International Journal of Neuroscience
https://www.readbyqxmd.com/read/28915428/compression-neuropathy-of-the-common-peroneal-nerve-caused-by-an-intraosseous-ganglion-cyst-of-fibula
#6
Adnan Kara, Sercan Yalçın, Haluk Çelik, Ersin Kuyucu, Ali Şeker
We present a case of a compression neuropathy of the common peroneal nerve caused by an intraosseous Ganglion cyst of fibula.
September 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28912362/sympathetic-function-during-whole-body-cooling-is-altered-in-hypertensive-adults
#7
Jody L Greaney, W Larry Kenney, Lacy M Alexander
During moderate cold exposure, cardiovascular-related morbidity and mortality increase disproportionately in hypertensive adults (HTN); however, the mechanisms underlying this association are not well defined. We hypothesized that whole-body cold stress would evoke exaggerated increases in blood pressure (BP) and muscle sympathetic nerve activity (MSNA) in HTN compared to normotensive adults (NTN) and that sympathetic baroreflex function would be altered during cooling in HTN. MSNA (peroneal microneurography) and beat-to-beat BP (Finometer) were measured continuously in 10 NTN (6M/4W; age 53±3 yrs; resting BP 125±3/79±1 mmHg) and 13 HTN (7M/6W; age 58±2 yrs; resting BP 146±5/88±2 mmHg) during whole-body cooling-induced reductions in mean skin temperature (Tsk; water-perfused suit) from 34...
September 14, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28901508/a-novel-method-for-obtaining-highly-enriched-schwann-cell-populations-from-mature-monkey-nerves-based-on-in-vitro-pre%C3%A2-degeneration
#8
Gangyang Wang, Zhengwen Ma, Lingling Cao, Guofeng Yan, Yang Wang, Yuqing Jin, Hua Shen, Yiping Zhang, Xiaoming Xu, Xuejin Chen, Zunli Shen
Schwann cells (SCs) are indispensable for cell therapy and tissue engineering of the peripheral nervous system. Easy access to activated, highly proliferative SCs is necessary for clinical applications. The present study developed a fast, efficient method for obtaining highly purified SCs from the peripheral nerve of a mature Rhesus monkey. The common peroneal nerves of 4‑year‑old Rhesus monkeys were harvested and subjected to in vitro pre‑degeneration in a modified SC culture medium (SCCM). The nerve pieces were subsequently treated enzymatically to dissociate the cells and then cultured for 2 days in SCCM...
September 5, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28900414/alterations-in-spectral-attributes-of-surface-electromyograms-after-utilization-of-a-foot-drop-stimulator-during-post-stroke-gait
#9
Rakesh Pilkar, Arvind Ramanujam, Karen J Nolan
BACKGROUND: A foot drop stimulator (FDS) is a rehabilitation intervention that stimulates the common peroneal nerve to facilitate ankle dorsiflexion at the appropriate time during post-stroke hemiplegic gait. Time-frequency analysis (TFA) of non-stationary surface electromyograms (EMG) and spectral variables such as instantaneous mean frequency (IMNF) can provide valuable information on the long-term effects of FDS intervention in terms of changes in the motor unit (MU) recruitment during gait, secondary to improved dorsiflexion...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28895442/an-alternate-technique-of-applying-lag-screw-for-fixation-of-distal-fibula-fracture-posterior-to-anterior-interfragmentary-compression-screw
#10
Suganth Jayaraman Vijimohan, Syed Haque, David Ellis
Ankle fractures are one of the most common lower limb fractures, representing a significant portion of the trauma workload. Marked proportion of these is isolated intraarticular lateral malleolus fractures. Anatomical reduction and rigid internal fixation using lag screw (interfragmentary screw) to provide interfragmentary compression has remained the choice of treatment in selected lateral malleolus fractures. Applying interfragmentary compression screw from anterior to the posterior surface of the fibula has been the traditional method of performing this...
September 1, 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28888335/dramatic-relapse-of-seizures-after-everolimus-withdrawal
#11
Alessia Mingarelli, Aglaia Vignoli, Francesca La Briola, Angela Peron, Lucio Giordano, Giuseppe Banderali, Maria Paola Canevini
Tuberous sclerosis complex (TSC) is an autosomal dominant multisystemic disorder caused by deregulation of the mTOR pathway, and represents one of the leading genetic causes of epilepsy. mTOR inhibitors (Sirolimus and Everolimus) are currently approved only for the treatment of growing subependymal giant cell astrocytomas, renal angiomyolipomas and lymphangioleiomyomatosis in TSC. However, preclinical and clinical evidence supports their potential role in effectively treating TSC-associated epilepsy, but no consensus on its use in seizures has been reached yet and there are few data on epilepsy outcome after the suspension of mTOR inhibitors treatment...
August 3, 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28887759/factors-contributing-to-chronic-ankle-instability-a-systematic-review-and-meta-analysis-of-systematic-reviews
#12
REVIEW
Cassandra Thompson, Siobhan Schabrun, Rick Romero, Andrea Bialocerkowski, Jaap van Dieen, Paul Marshall
BACKGROUND: Many factors are thought to contribute to chronic ankle instability (CAI). Multiple systematic reviews have synthesised the available evidence to identify the primary contributing factors. However, readers are now faced with several systematic reviews that present conflicting findings. OBJECTIVE: The aim of this systematic review and meta-analysis was to establish the statistical significance and effect size of primary factors contributing to CAI and to identify likely reasons for inconsistencies in the literature...
September 8, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28887003/effects-of-acupuncture-at-the-st-36-point-on-muscle-sympathetic-nerve-activity-and-blood-pressure-in-normal-adults
#13
Kenichi Kimura, Kazuya Ishida, Noriyo Takahashi, Yasushi Toge, Fumihiro Tajima
The aim of the present study was to determine the effects of acupuncture on post-ganglionic muscle sympathetic nerve activity (MSNA) in humans. MSNA was measured in 8 healthy adult males by microneurography evaluation of the left peroneal nerve. Blood pressure (BP) and heart rate (HR) were simultaneously recorded. MSNA was evaluated as the burst rate, with total MSNA, BP and HR normalized to their respective baseline values. After 10min of rest in the supine position, acupuncture was applied to the right ST-36 point in the tibialis anterior muscle for 15min, with recovery then monitored over a 20-min period...
September 1, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28884985/staged-endovascular-repair-of-critical-limb-ischemia-in-high-risk-patients-the-procedural-and-clinical-outcomes
#14
Guang Liu, Chaoyi Cui, Minyi Yin, Kaichuang Ye, Xaiobing Liu, Jinbao Qin, Huihua Shi, Xintian Huang, Min Lu, Xinwu Lu, Weimin Li, Mier Jiang
PURPOSE: To retrospectively evaluate the procedural and clinical outcomes after staged angioplasty in high-risk, chronic, critical limb ischemia (CLI) patients. METHODS: Between 2013 and 2015, 29 patients (29 limbs) (mean age 77 years) were treated by staged revascularization procedures in (i) the iliac artery-DFA alone or with the femoropopliteal artery followed by (ii) the femoropopliteal artery and a below-the-knee artery. All patients had long-segment iliofemoral artery and below-the-knee artery (TASCII D) occlusions with abnormal serum myoglobin and ischemic lesions...
September 7, 2017: International Angiology: a Journal of the International Union of Angiology
https://www.readbyqxmd.com/read/28878898/tourniquet-induced-common-peroneal-nerve-injury-in-a-pediatric-patient-after-knee-arthroscopy-raising-the-red-flag
#15
Kah Ming Saw, Hwan Ing Hee
Peripheral nerve injury following the use of arterial tourniquets is a rare but potentially debilitating complication. Further education on the safe and appropriate practice of tourniquets is imperative to reduce the incidence of tourniquet-related complications.
September 2017: Clinical Case Reports
https://www.readbyqxmd.com/read/28876598/spectrum-of-disease-and-outcome-of-primary-amputation-for-diabetic-foot-sepsis
#16
S Cheddie, C Manneh, H Zulu
BACKGROUND: Guillotine amputation for diabetic foot sepsis followed by an elective refashioning of the stump is regarded as standard practice. Primary amputation is associated with higher reamputation rates. METHOD: A prospective cohort study of 85 patients who underwent surgery for diabetic foot sepsis from 2014 to 2016 at Madadeni Provincial Hospital, KwaZulu-Natal was done. Ethical approval was granted. The Wagner classification (Wag) was used to classify disease severity...
September 2017: South African Journal of Surgery. Suid-Afrikaanse Tydskrif Vir Chirurgie
https://www.readbyqxmd.com/read/28874063/venous-thromboprophylaxis-with-neuromuscular-stimulation-is-it-calf-muscle-pumping-or-just-twitches-and-jerks
#17
Christopher R Lattimer, Vassilios Zymvragoudakis, George Geroulakos, Evi Kalodiki
The common peroneal nerve stimulator (CPNS) is a UK-approved device for reducing venous thromboembolism risk. It resembles a wrist watch and is placed over the common peroneal nerve to fire at 1 electrical impulse/sec. The aim was to quantify the claim that it drives the venous muscle pump and imitates walking. Twelve healthy volunteers performed 10 tip-toe maneuvers and 10 ankle dorsiflexions to imitate walking movements. The reductions in calf volume were recorded using air plethysmography (APG). The common peroneal nerve was stimulated for over 10 seconds at each of the 7 increasing electrical impulse settings, and the volume reductions were measured for comparison...
January 1, 2017: Clinical and Applied Thrombosis/hemostasis
https://www.readbyqxmd.com/read/28869435/in-vivo-effects-of-limb-movement-on-nerve-stretch-strain-and-tension-a-systematic-review
#18
Tibor Szikszay, Toby Hall, Harry von Piekartz
BACKROUND: The mechanical behavior of the peripheral nervous system under elongation and tension has not been adequately established in vivo. OBJECTIVE: The purpose of this review is to investigate the mechanical behavior of the peripheral nervous system in vivo. METHODS: In vivo studies which evaluated the effects of limb movement and neurodynamic tests on peripheral nerve biomechanics were systematically searched in PubMed (Medline), the Cochrane Database, CINAHL, PEDro, Embase and Web of Science...
August 25, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28869039/-bilateral-acute-iris-transillumination-syndrome-case-report
#19
J M Perone, S Reynders, N Sujet-Perone, R Yahia, E Neiter, P Krawczyk, F Tortuyaux, M Sot, L Lhuillier
No abstract text is available yet for this article.
August 28, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28868940/vigilance-on-use-of-drugs-herbal-products-and-food-supplements-during-pregnancy-focus-on-fosfomycin
#20
C Mannucci, G Dante, M Miroddi, F Facchinetti, R D'Anna, A Santamaria, M C Lenti, A Vannacci, F Calapai, M Perone, G Migliardi, A Alibrandi, M Navarra, G Calapai
Urinary tract infection (UTI) is defined as a common bacterial infection that can lead to significant morbidity such as stricture, fistula, abscess formation, bacteremia, sepsis, pyelonephritis and kidney dysfunction with a mortality rates reported of 1% in men and 3% in women because of development of pyelonephritis. UTIs are more common in women and the 33% of them, requires antimicrobials treatment for at least 1 episode by the age of 24 years. UTIs are the most common infections observed during pregnancy and up to 30% of mothers with not treated asymptomatic bacteriuria may develop acute pyelonephritis which consequently can be associated to adverse maternal and fetal outcomes...
September 4, 2017: Journal of Maternal-fetal & Neonatal Medicine
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