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https://www.readbyqxmd.com/read/27919760/proton-therapy-present-and-future
#1
REVIEW
Radhe Mohan, David Grosshans
In principle, proton therapy offers a substantial clinical advantage over the conventional photon therapy. This is because of the unique depth-dose characteristics of protons, which can be exploited to achieve significant reductions in normal tissue doses proximal and distal to the target volume. These may, in turn, allow escalation of tumor doses, greater sparing of normal tissues, thus potentially improving local control and survival while at the same time reducing toxicity and improving quality of life. Protons, accelerated to therapeutic energies ranging from 70 to 250MeV, typically with a cyclotron or a synchrotron, are transported to the treatment room where they enter the treatment head mounted on a rotating gantry...
December 2, 2016: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/27869083/spot-scanning-proton-arc-sparc-therapy-the-first-robust-and-delivery-efficient-spot-scanning-proton-arc-therapy
#2
Xuanfeng Ding, Xiaoqiang Li, J Michele Zhang, Peyman Kabolizadeh, Craig Stevens, Di Yan
PURPOSE: To present a novel robust and delivery-efficient spot-scanning proton arc (SPArc) therapy technique. METHODS AND MATERIALS: A SPArc optimization algorithm was developed that integrates control point resampling, energy layer redistribution, energy layer filtration, and energy layer resampling. The feasibility of such a technique was evaluated using sample patients: 1 patient with locally advanced head and neck oropharyngeal cancer with bilateral lymph node coverage, and 1 with a nonmobile lung cancer...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27869082/reoptimization-of-intensity-modulated-proton-therapy-plans-based-on-linear-energy-transfer
#3
Jan Unkelbach, Pablo Botas, Drosoula Giantsoudi, Bram L Gorissen, Harald Paganetti
PURPOSE: We describe a treatment plan optimization method for intensity modulated proton therapy (IMPT) that avoids high values of linear energy transfer (LET) in critical structures located within or near the target volume while limiting degradation of the best possible physical dose distribution. METHODS AND MATERIALS: To allow fast optimization based on dose and LET, a GPU-based Monte Carlo code was extended to provide dose-averaged LET in addition to dose for all pencil beams...
December 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27811403/prioritized-efficiency-optimization-for-intensity-modulated-proton-therapy
#4
Birgit S Müller, Jan J Wilkens
A high dosimetric quality and short treatment time are major goals in radiotherapy planning. Intensity modulated proton therapy (IMPT) plans obtain dose distributions of great conformity but often result in long delivery times which are typically not incorporated into the optimization process. We present an algorithm to optimize delivery efficiency of IMPT plans while maintaining plan quality, and study the potential trade-offs of these interdependent objectives. The algorithm is based on prioritized optimization, a stepwise approach to implemented objectives...
December 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27806620/factors-influencing-the-performance-of-patient-specific-quality-assurance-for-pencil-beam-scanning-impt-fields
#5
P Trnková, A Bolsi, F Albertini, D C Weber, A J Lomax
PURPOSE: A detailed analysis of 2728 intensity modulated proton therapy (IMPT) fields that were clinically delivered to patients between 2007 and 2013 at Paul Scherrer Institute (PSI) was performed. The aim of this study was to analyze the results of patient specific dosimetric verifications and to assess possible correlation between the quality assurance (QA) results and specific field metrics. METHODS: Dosimetric verifications were performed for every IMPT field prior to patient treatment...
November 2016: Medical Physics
https://www.readbyqxmd.com/read/27782706/investigating-deformable-image-registration-and-scatter-correction-for-cbct-based-dose-calculation-in-adaptive-impt
#6
Christopher Kurz, Florian Kamp, Yang-Kyun Park, Christoph Zöllner, Simon Rit, David Hansen, Mark Podesta, Gregory C Sharp, Minglun Li, Michael Reiner, Jan Hofmaier, Sebastian Neppl, Christian Thieke, Reinoud Nijhuis, Ute Ganswindt, Claus Belka, Brian A Winey, Katia Parodi, Guillaume Landry
PURPOSE: This work aims at investigating intensity corrected cone-beam x-ray computed tomography (CBCT) images for accurate dose calculation in adaptive intensity modulated proton therapy (IMPT) for prostate and head and neck (H&N) cancer. A deformable image registration (DIR)-based method and a scatter correction approach using the image data obtained from DIR as prior are characterized and compared on the basis of the same clinical patient cohort for the first time. METHODS: Planning CT (pCT) and daily CBCT data (reconstructed images and measured projections) of four H&N and four prostate cancer patients have been considered in this study...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27741379/dosimetric-and-radiobiological-impact-of-intensity-modulated-proton-therapy-and-rapidarc-planning-for-high-risk-prostate-cancer-with-seminal-vesicles
#7
Suresh Rana, ChihYao Cheng, Li Zhao, SungYong Park, Gary Larson, Carlos Vargas, Megan Dunn, Yuanshui Zheng
INTRODUCTION: The purpose of this study was to evaluate the dosimetric and radiobiological impact of intensity modulated proton therapy (IMPT) and RapidArc planning for high-risk prostate cancer with seminal vesicles. METHODS: Ten high-risk prostate cancer cases were included in this retrospective study. For each case, IMPT plans were generated using multiple field optimisation (MFO) technique (two fields) with XiO treatment planning system (TPS), whereas RapidArc plans were generated using double-arc technique (two full arcs) with Eclipse TPS...
May 11, 2016: Journal of Medical Radiation Sciences
https://www.readbyqxmd.com/read/27736917/optimization-of-carbon-ion-treatment-plans-by-integrating-tissue-specific-%C3%AE-%C3%AE-values-for-patients-with-non-resectable-pancreatic-cancer
#8
Constantin Dreher, Christian Scholz, Mira Pommer, Stephan Brons, Hannah Prokesch, Swantje Ecker, Jürgen Debus, Oliver Jäkel, Stephanie E Combs, Daniel Habermehl
BACKGROUND: The aim of the thesis is to improve treatment plans of carbon ion irradiation by integrating the tissues' specific [Formula: see text]-values for patients with locally advanced pancreatic cancer (LAPC). MATERIAL AND METHODS: Five patients with LAPC were included in this study. By the use of the treatment planning system Syngo RT Planning (Siemens, Erlangen, Germany) treatment plans with carbon ion beams have been created. Dose calculation was based on [Formula: see text]-values for both organs at risk (OAR) and the tumor...
2016: PloS One
https://www.readbyqxmd.com/read/27717342/impact-is-a-gcn2-inhibitor-that-limits-lifespan-in-caenorhabditis-elegans
#9
Rafael C Ferraz, Henrique Camara, Evandro A De-Souza, Silas Pinto, Ana Paula F Pinca, Richard C Silva, Vitor N Sato, Beatriz A Castilho, Marcelo A Mori
BACKGROUND: The General Control Nonderepressible 2 (GCN2) kinase is a conserved member of the integrated stress response (ISR) pathway that represses protein translation and helps cells to adapt to conditions of nutrient shortage. As such, GCN2 is required for longevity and stress resistance induced by dietary restriction (DR). IMPACT is an ancient protein that inhibits GCN2. RESULTS: Here, we tested whether IMPACT down-regulation mimics the effects of DR in C. elegans...
October 7, 2016: BMC Biology
https://www.readbyqxmd.com/read/27699537/optimizing-radiotherapy-in-hpv-associated-oropharyngeal-cancer-patients
#10
Johannes A Langendijk, Roel J H M Steenbakkers
Concurrent chemoradiation is considered the golden standard in the treatment of locally advanced OPC. However, given the very high survival rates in favorable HPV-positive OPC and the high rates of acute and late treatment-related side effects, de-escalation strategies have to be considered. In this chapter, the potential benefit of a number of de-escalation strategies is described, including of replacement of concurrent chemotherapy by cetuximab, radiation dose de-escalation based on response to induction chemotherapy, radiotherapy alone without systemic treatment, and limiting elective nodal target volumes for radiation...
2017: Recent Results in Cancer Research
https://www.readbyqxmd.com/read/27681763/limited-impact-of-setup-and-range-uncertainties-breathing-motion-and-interplay-effects-in-robustly-optimized-intensity-modulated-proton-therapy-for-stage-iii-non-small-cell-lung-cancer
#11
Tatsuya Inoue, Joachim Widder, Lisanne V van Dijk, Hideki Takegawa, Masahiko Koizumi, Masaaki Takashina, Keisuke Usui, Chie Kurokawa, Satoru Sugimoto, Anneyuko I Saito, Keisuke Sasai, Aart A Van't Veld, Johannes A Langendijk, Erik W Korevaar
PURPOSE: To investigate the impact of setup and range uncertainties, breathing motion, and interplay effects using scanning pencil beams in robustly optimized intensity modulated proton therapy (IMPT) for stage III non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: Three-field IMPT plans were created using a minimax robust optimization technique for 10 NSCLC patients. The plans accounted for 5- or 7-mm setup errors with ±3% range uncertainties. The robustness of the IMPT nominal plans was evaluated considering (1) isotropic 5-mm setup errors with ±3% range uncertainties; (2) breathing motion; (3) interplay effects; and (4) a combination of items 1 and 2...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675854/phase-1-trial-of-preoperative-image-guided-intensity-modulated-proton-radiation-therapy-impt-with-simultaneously-integrated-boost-to-the-high-risk-margin-for-retroperitoneal-sarcomas
#12
T F DeLaney, Y L E Chen, J A Adams, S Hickey, D Wang, E H Baldini, K Bernstein, B Y Yeap, S M Hahn, G P Nielsen, E Choy, J T Mullen, S S Yoon
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27675332/dosimetric-comparison-of-intensity-modulated-proton-therapy-impt-partial-breast-irradiation-pbi-and-a-breast-stereotactic-radiation-therapy-bsrt-device
#13
E M Nichols, J W Snider, B Zhang, A Hall, S J Becker, S N Badiyan, Y D Mutaf, S J Feigenberg
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674364/can-intensity-modulated-proton-therapy-impt-be-an-alternative-to-image-guided-brachytherapy-igbt-for-locally-advanced-cervical-cancer
#14
H C Kuo, K J Mehta, R Yaparpalvi, M Garg, W R Bodner, M W Ho, W A Tome, S Kalnicki
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27673897/modeling-of-high-grade-hematologic-toxicity-in-anal-cancer-patients-treated-with-intensity-modulated-proton-therapy-impt-and-volumetric-modulated-arc-therapy-vmat
#15
T Meier, A Mascia, E Wolf, J R Kharofa
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27639891/benefit-of-particle-therapy-in-re-irradiation-of-head-and-neck-patients-results-of-a-multicentric-in-silico-rococo-trial
#16
Daniëlle B P Eekers, Erik Roelofs, Urszula Jelen, Maura Kirk, Marlies Granzier, Filippo Ammazzalorso, Peter H Ahn, Geert O R J Janssens, Frank J P Hoebers, Tobias Friedmann, Timothy Solberg, Sean Walsh, Esther G C Troost, Johannes H A M Kaanders, Philippe Lambin
BACKGROUND AND PURPOSE: In this multicentric in silico trial we compared photon, proton, and carbon-ion radiotherapy plans for re-irradiation of patients with squamous cell carcinoma of the head and neck (HNSCC) regarding dose to tumour and doses to surrounding organs at risk (OARs). MATERIAL AND METHODS: Twenty-five HNSCC patients with a second new or recurrent cancer after previous irradiation (70Gy) were included. Intensity-modulated proton therapy (IMPT) and ion therapy (IMIT) re-irradiation plans to a second subsequent dose of 70Gy were compared to photon therapy delivered with volumetric modulated arc therapy (VMAT)...
September 14, 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27506808/reduced-acute-toxicity-and-improved-efficacy-from-intensity-modulated-proton-therapy-impt-for-the-management-of-head-and-neck-cancer
#17
Matthew R McKeever, Terence T Sio, G Brandon Gunn, Emma B Holliday, Pierre Blanchard, Merrill S Kies, Randal S Weber, Steven J Frank
Cancers in the head and neck area are usually close to several critical organ structures. Traditional external-beam photon radiation therapy unavoidably exposes these structures to significant doses of radiation, which can lead to serious acute and chronic toxicity. Intensity-modulated proton therapy (IMPT), however, has dosimetric advantages that allow it to deposit high doses within the target while largely sparing surrounding structures. Because of this advantage, IMPT has the potential to improve both tumor control and toxicity...
August 2016: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/27487880/feasibility-of-mri-only-treatment-planning-for-proton-therapy-in-brain-and-prostate-cancers-dose-calculation-accuracy-in-substitute-ct-images
#18
Lauri Koivula, Leonard Wee, Juha Korhonen
PURPOSE: Magnetic resonance imaging (MRI) is increasingly used for radiotherapy target delineation, image guidance, and treatment response monitoring. Recent studies have shown that an entire external x-ray radiotherapy treatment planning (RTP) workflow for brain tumor or prostate cancer patients based only on MRI reference images is feasible. This study aims to show that a MRI-only based RTP workflow is also feasible for proton beam therapy plans generated in MRI-based substitute computed tomography (sCT) images of the head and the pelvis...
August 2016: Medical Physics
https://www.readbyqxmd.com/read/27452411/which-cervical-and-endometrial-cancer-patients-will-benefit-most-from-intensity-modulated-proton-therapy
#19
Mariska A E van de Sande, Carien L Creutzberg, Steven van de Water, Abdul Wahab Sharfo, Mischa S Hoogeman
In this dosimetric comparison study it was shown that IMPT with robust planning reduces dose to surrounding organs in cervical and endometrial cancer treatment compared with IMRT. Especially for the para-aortic region, clinically relevant dose reductions were obtained for kidneys, spinal cord and bowel, justifying the use of proton therapy for this indication.
September 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/27424291/modelling-of-organ-specific-radiation-induced-secondary-cancer-risks-following-particle-therapy
#20
Camilla H Stokkevåg, Mai Fukahori, Takuma Nomiya, Naruhiro Matsufuji, Grete May Engeseth, Liv B Hysing, Kristian S Ytre-Hauge, Eivind Rørvik, Artur Szostak, Ludvig P Muren
BACKGROUND AND PURPOSE: Radiation-induced cancer is a serious late effect that may follow radiotherapy. A considerable uncertainty is associated with carcinogenesis from photon-based treatment, and even less established when including relative biological effectiveness (RBE) for particle therapy. The aim of this work was therefore to estimate and in particular explore relative risks (RR) of secondary cancer (SC) following particle therapy as applied in treatment of prostate cancer. MATERIAL AND METHODS: RRs of radiation-induced SC in the bladder and rectum were estimated using a bell-shaped dose-response model incorporating RBE and fractionation effects...
August 2016: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
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