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https://www.readbyqxmd.com/read/28810881/comparison-of-photon-volumetric-modulated-arc-therapy-intensity-modulated-proton-therapy-and-intensity-modulated-carbon-ion-therapy-for-delivery-of-hypo-fractionated-thoracic-radiotherapy
#1
Alexander Chi, Lien-Chun Lin, Sijin Wen, Haijuan Yan, Wen-Chien Hsi
PURPOSE: The aim of the present study was to compare the dose distribution generated from photon volumetric modulated arc therapy (VMAT), intensity modulated proton therapy (IMPT), and intensity modulated carbon ion therapy (IMCIT) in the delivery of hypo-fractionated thoracic radiotherapy. METHODS AND MATERIALS: Ten selected patients who underwent thoracic particle therapy between 2015 and 2016 were re-planned to receive a relative biological effectiveness (RBE) weighted dose of 60 Gy (i...
August 15, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28740917/phase-1-trial-of-preoperative-image-guided-intensity-modulated-proton-radiation-therapy-with-simultaneously-integrated-boost-to-the-high-risk-margin-for-retroperitoneal-sarcomas
#2
Thomas F DeLaney, Yen-Lin Chen, Elizabeth H Baldini, Dian Wang, Judith Adams, Shea B Hickey, Beow Y Yeap, Stephen M Hahn, Karen De Amorim Bernstein, G Petur Nielsen, Edwin Choy, John T Mullen, Sam S Yoon
PURPOSE: To conduct phase 1 and 2 trials with photon intensity modulated radiation therapy and intensity modulated proton therapy (IMPT) arms to selectively escalate the retroperitoneal sarcoma preoperative radiation dose to tumor volume (clinical target volume [CTV] 2) that is judged to be at a high risk for positive margins and aim to reduce local recurrence. We report on the IMPT study arm in phase 1. METHODS AND MATERIALS: Patients aged ≥18 years with primary or locally recurrent retroperitoneal sarcoma were treated with preoperative IMPT, 50...
January 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28684206/-patient-first-the-impact-of-characteristics-of-target-populations-on-decisions-about-therapy-effectiveness-of-complex-interventions-psychological-variables-to-assess-effectiveness-in-interdisciplinary-multimodal-pain-therapy
#3
Ulrike Kaiser, Rainer Sabatowski, Friedrich Balck
INTRODUCTION: The assessment of treatment effectiveness in public health settings is ensured by indicators that reflect the changes caused by specific interventions. These indicators are also applied in benchmarking systems. The selection of constructs should be guided by their relevance for affected patients (patient reported outcomes). The interdisciplinary multimodal pain therapy (IMPT) is a complex intervention based on a biopsychosocial understanding of chronic pain. For quality assurance purposes, psychological parameters (depression, general anxiety, health-related quality of life) are included in standardized therapy assessment in pain medicine (KEDOQ), which can also be used for comparative analyses in a benchmarking system...
July 3, 2017: Zeitschrift Für Evidenz, Fortbildung und Qualität Im Gesundheitswesen
https://www.readbyqxmd.com/read/28681976/mixed-integer-programming-with-dose-volume-constraints-in-intensity-modulated-proton-therapy
#4
Pengfei Zhang, Neng Fan, Jie Shan, Steven E Schild, Martin Bues, Wei Liu
BACKGROUND: In treatment planning for intensity-modulated proton therapy (IMPT), we aim to deliver the prescribed dose to the target yet minimize the dose to adjacent healthy tissue. Mixed-integer programming (MIP) has been applied in radiation therapy to generate treatment plans. However, MIP has not been used effectively for IMPT treatment planning with dose-volume constraints. In this study, we incorporated dose-volume constraints in an MIP model to generate treatment plans for IMPT...
July 6, 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28660417/-what-does-pain-intensity-mean-from-the-patient-perspective-a-qualitative-study-on-the-patient-perspective-of-pain-intensity-as-an-outcome-parameter-in-treatment-evaluation-and-on-the-interpretability-of-pain-intensity-measurements
#5
K Neustadt, S Deckert, C Kopkow, A Preißler, B Bosse, C Funke, L Jacobi, P Mattenklodt, B Nagel, P Seidel, R Sittl, E Steffen, R Sabatowski, J Schmitt, U Kaiser
BACKGROUND: Pain intensity (PI) is a common outcome parameter in effectiveness studies on interdisciplinary multimodal pain therapy (IMPT), despite the fact that IMPT highlights dealing with rather than reducing chronic pain. Moreover, the measurement of pain intensity as a highly subjective experience is problematic. Patient participation is absolutely essential to examine the relevance of PI as a criterion of treatment success as well as to select/develop suitable measurement methods...
June 28, 2017: Der Schmerz
https://www.readbyqxmd.com/read/28649976/efficiency-of-analytical-and-sampling-based-uncertainty-propagation-in-intensity-modulated-proton-therapy
#6
N Wahl, P Hennig, H P Wieser, M Bangert
The sensitivity of intensity-modulated proton therapy (IMPT) treatment plans to uncertainties can be quantified and mitigated with robust/min-max and stochastic/probabilistic treatment analysis and optimization techniques. Those methods usually rely on sparse random, importance, or worst-case sampling. Inevitably, this imposes a trade-off between computational speed and accuracy of the uncertainty propagation. Here, we investigate analytical probabilistic modeling (APM) as an alternative for uncertainty propagation and minimization in IMPT that does not rely on scenario sampling...
June 26, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28587051/evaluating-intensity-modulated-proton-therapy-relative-to-passive-scattering-proton-therapy-for-increased-vertebral-column-sparing-in-craniospinal-irradiation-in-growing-pediatric-patients
#7
Drosoula Giantsoudi, Joao Seco, Bree R Eaton, F Joseph Simeone, Hanne Kooy, Torunn I Yock, Nancy J Tarbell, Thomas F DeLaney, Judith Adams, Harald Paganetti, Shannon M MacDonald
PURPOSE: At present, proton craniospinal irradiation (CSI) for growing children is delivered to the whole vertebral body (WVB) to avoid asymmetric growth. We aimed to demonstrate the feasibility and potential clinical benefit of delivering vertebral body sparing (VBS) versus WVB CSI with passively scattered (PS) and intensity modulated proton therapy (IMPT) in growing children treated for medulloblastoma. METHODS AND MATERIALS: Five plans were generated for medulloblastoma patients, who had been previously treated with CSI PS proton radiation therapy: (1) single posteroanterior (PA) PS field covering the WVB (PS-PA-WVB); (2) single PA PS field that included only the thecal sac in the target volume (PS-PA-VBS); (3) single PA IMPT field covering the WVB (IMPT-PA-WVB); (4) single PA IMPT field, target volume including thecal sac only (IMPT-PA-VBS); and (5) 2 posterior-oblique (-35°, +35°) IMPT fields, with the target volume including the thecal sac only (IMPT2F-VBS)...
May 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28569997/impact-of-spot-charge-inaccuracies-in-impt-treatments
#8
Aafke C Kraan, Nicolas Depauw, Ben Clasie, Marina Giunta, Tom Madden, Hanne M Kooy
BACKGROUND: Spot charge is one parameter of pencil-beam scanning dose delivery system whose accuracy is typically high but whose required value has not been investigated. In this work we quantify the dose impact of spot charge inaccuracies on the dose distribution in patients. Knowing the effect of charge errors is relevant for conventional proton machines, as well as for new generation proton machines, where ensuring accurate charge may be challenging. METHODS: Through perturbation of spot charge in treatment plans for seven patients and a phantom, we evaluated the dose impact of absolute (up to 5× 10(6) protons) and relative (up to 30%) charge errors...
August 2017: Medical Physics
https://www.readbyqxmd.com/read/28549794/intensity-modulated-proton-therapy-and-osteoradionecrosis-in-oropharyngeal-cancer
#9
Wencheng Zhang, Xiaodong Zhang, Pei Yang, Pierre Blanchard, Adam S Garden, Brandon Gunn, C David Fuller, Mark Chambers, Katherine A Hutcheson, Rong Ye, Stephen Y Lai, Mohamed Abdallah Sherif Radwan, X Ron Zhu, Steven J Frank
PURPOSE: We compared mandibular doses and osteoradionecrosis in patients with oropharyngeal cancer after intensity-modulated radiation therapy (IMRT) or intensity-modulated proton therapy (IMPT). METHODS AND MATERIALS: We identified 584 patients who received definitive radiotherapy for oropharyngeal cancer from January 2011 through June 2014 at MD Anderson Cancer Center (534 IMRT and 50 IMPT). The dosimetric variables and osteoradionecrosis were compared with Chi-square test or Fisher's exact test...
May 23, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28464742/functional-image-guided-dose-escalation-in-gliomas-using-of-state-of-the-art-photon-vs-proton-therapy
#10
Anne Ivalu Sander Holm, Jørgen Breede Baltzer Petersen, Ludvig Paul Muren, Klaus Seiersen, Per Borghammer, Slávka Lukacova
BACKGROUND: Recurrences of glioma are usually local, suggesting the need for higher tumor dose. We investigated the boundaries for dose escalation of an (18)F-fluoro-ethyl-tyrosine positron emission tomography defined target by intensity-modulated photon therapy (IMRT), volumetric modulated arc therapy (VMAT) and intensity-modulated proton therapy (IMPT). MATERIALS AND METHODS: Standard dose (60 Gy) and dose-escalated plans were calculated for seven patients using IMRT, VMAT and IMPT...
June 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28464733/evaluating-the-influence-of-organ-motion-during-photon-vs-proton-therapy-for-locally-advanced-prostate-cancer-using-biological-models
#11
Kia Busch, Andreas G Andersen, Oscar Casares-Magaz, Jørgen B B Petersen, Lise Bentzen, Sara Thörnqvist, Ludvig P Muren
BACKGROUND: Proton therapy (PT) may have a normal tissue sparing potential when co-irradiating pelvic lymph nodes in patients with locally advanced prostate cancer, but may also be more sensitive towards organ motion in the pelvis. Building upon a previous study identifying motion-robust proton beam angles for pelvic irradiation, we aimed to evaluate the influence of organ motion for PT using biological models, and to compare this with contemporary photon-based RT. MATERIAL AND METHODS: Eight locally advanced prostate cancer patients with a planning CT (pCT) and 8-9 repeated CT scans (rCTs) were included...
June 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28423966/linear-energy-transfer-distributions-in-the-brainstem-depending-on-tumour-location-in-intensity-modulated-proton-therapy-of-paediatric-cancer
#12
Lars Fredrik Fjæra, Zuofeng Li, Kristian S Ytre-Hauge, Ludvig P Muren, Daniel J Indelicato, Yasmin Lassen-Ramshad, Grete May Engeseth, Marianne Brydøy, Andrea Mairani, Stella Flampouri, Olav Dahl, Camilla H Stokkevåg
BACKGROUND: For tumours near organs at risk, there is concern about unintended increase in biological dose from elevated linear energy transfer (LET) at the distal end of treatment fields. The objective of this study was therefore to investigate how different paediatric posterior fossa tumour locations impact LET and biological dose to the brainstem during intensity-modulated proton therapy (IMPT). MATERIAL AND METHODS: Multiple IMPT plans were generated for four different simulated tumour locations relative to the brainstem for a five-year-old male patient...
April 19, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28380636/the-role-of-image-guided-intensity-modulated-proton-therapy-in-glioma
#13
David R Grosshans, Radhe Mohan, Vinai Gondi, Helen A Shih, Anita Mahajan, Paul D Brown
Gliomas represent a broad spectrum of disease with life-expectancy outcomes ranging from months to decades. As our understanding of the molecular profiles of gliomas expands rapidly, practitioners are now better able to identify patients with favorable versus nonfavorable prognoses. Radiation therapy plays a key role in glioma treatment, improving disease control and oftentimes survival. However, for survivors, either long-term or short-term, radiation-induced cognitive impairments may negatively impact their quality of life...
April 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28366554/comparative-study-of-the-calculated-risk-of-radiation-induced-cancer-after-photon-and-proton-beam-based-radiosurgery-of-liver-metastases
#14
Gracinda Mondlane, Michael Gubanski, Pehr A Lind, Ana Ureba, Albert Siegbahn
INTRODUCTION: The potential of proton therapy to improve the sparing of the healthy tissue has been demonstrated in several studies. However, even small doses delivered to the organs at risk (OAR) may induce long-term detriments after radiotherapy. In this study, we investigated the possibility to reduce the risk of radiation-induced secondary cancers with intensity modulated proton therapy (IMPT), when used for radiosurgery of liver metastases. MATERIAL AND METHODS: Ten patients, previously treated for liver metastases with photon-beam based stereotactic body radiation therapy (SBRT) were retrospectively planned for radiosurgery with IMPT...
March 30, 2017: Physica Medica: PM
https://www.readbyqxmd.com/read/28341315/initial-clinical-experience-of-postmastectomy-intensity-modulated-proton-therapy-in-patients-with-breast-expanders-with-metallic-ports
#15
Robert W Mutter, Nicholas B Remmes, Mohamed Mh Kahila, Kathy A Hoeft, Deanna H Pafundi, Yan Zhang, Kimberly S Corbin, Sean S Park, Elizabeth S Yan, Valerie Lemaine, Judy C Boughey, Chris J Beltran
PURPOSE: The feasibility of proton postmastectomy radiation therapy in patients reconstructed with expanders has not been previously reported, limiting treatment options. We analyzed the dosimetric impact of the metallic port contained within expanders on intensity modulated proton therapy (IMPT) and report our techniques and quality control for treating patients in this setting. METHODS AND MATERIALS: Twelve patients with the same expander model underwent 2-field IMPT as part of a prospective registry...
December 16, 2016: Practical Radiation Oncology
https://www.readbyqxmd.com/read/28300378/comparison-of-linear-and-nonlinear-programming-approaches-for-worst-case-dose-and-minmax-robust-optimization-of-intensity-modulated-proton-therapy-dose-distributions
#16
Maryam Zaghian, Wenhua Cao, Wei Liu, Laleh Kardar, Sharmalee Randeniya, Radhe Mohan, Gino Lim
Robust optimization of intensity-modulated proton therapy (IMPT) takes uncertainties into account during spot weight optimization and leads to dose distributions that are resilient to uncertainties. Previous studies demonstrated benefits of linear programming (LP) for IMPT in terms of delivery efficiency by considerably reducing the number of spots required for the same quality of plans. However, a reduction in the number of spots may lead to loss of robustness. The purpose of this study was to evaluate and compare the performance in terms of plan quality and robustness of two robust optimization approaches using LP and nonlinear programming (NLP) models...
March 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28281862/model-based-approach-for-quantitative-estimates-of-skin-heart-and-lung-toxicity-risk-for-left-side-photon-and-proton-irradiation-after-breast-conserving-surgery
#17
Francesco Tommasino, Marco Durante, Vittoria D'Avino, Raffaele Liuzzi, Manuel Conson, Paolo Farace, Giuseppe Palma, Marco Schwarz, Laura Cella, Roberto Pacelli
BACKGROUND: Proton beam therapy represents a promising modality for left-side breast cancer (BC) treatment, but concerns have been raised about skin toxicity and poor cosmesis. The aim of this study is to apply skin normal tissue complication probability (NTCP) model for intensity modulated proton therapy (IMPT) optimization in left-side BC. MATERIAL AND METHODS: Ten left-side BC patients undergoing photon irradiation after breast-conserving surgery were randomly selected from our clinical database...
May 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28140380/near-real-time-automated-dose-restoration-in-impt-to-compensate-for-daily-tissue-density-variations-in-prostate-cancer
#18
Thyrza Jagt, Sebastiaan Breedveld, Steven van de Water, Ben Heijmen, Mischa Hoogeman
Proton therapy is very sensitive to daily density changes along the pencil beam paths. The purpose of this study is to develop and evaluate an automated method for adaptation of IMPT plans to compensate for these daily tissue density variations. A two-step restoration method for 'densities-of-the-day' was created: (1) restoration of spot positions (Bragg peaks) by adapting the energy of each pencil beam to the new water equivalent path length; and (2) re-optimization of pencil beam weights by minimizing the dosimetric difference with the planned dose distribution, using a fast and exact quadratic solver...
January 31, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28114107/generation-of-synthetic-ct-data-using-patient-specific-daily-mr-image-data-and-image-registration
#19
Kim Melanie Kraus, Oliver Jäkel, Nina I Niebuhr, Asja Pfaffenberger
To fully exploit the advantages of magnetic resonance imaging (MRI) for radiotherapy (RT) treatment planning, a method is required to overcome the problem of lacking electron density information. We aim to establish and evaluate a new method for computed tomography (CT) data generation based on MRI and image registration. The thereby generated CT data is used for dose accumulation. We developed a process flow based on an initial pair of rigidly co-registered CT and T2-weighted MR image representing the same anatomical situation...
February 21, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28077128/treatment-planning-comparison-of-impt-vmat-and-4%C3%AF-radiotherapy-for-prostate-cases
#20
COMPARATIVE STUDY
Angelia Tran, Jingjing Zhang, Kaley Woods, Victoria Yu, Dan Nguyen, Gary Gustafson, Lane Rosen, Ke Sheng
BACKGROUND: Intensity-modulated proton therapy (IMPT), non-coplanar 4π intensity-modulated radiation therapy (IMRT), and volumetric-modulated arc therapy (VMAT) represent the most advanced treatment methods based on heavy ion and X-rays, respectively. Here we compare their performance for prostate cancer treatment. METHODS: Ten prostate patients were planned using IMPT with robustness optimization, VMAT, and 4π to an initial dose of 54 Gy to a clinical target volume (CTV) that encompassed the prostate and seminal vesicles, then a boost prescription dose of 25...
January 11, 2017: Radiation Oncology
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