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endocrinology of exercise

Si-Fan Cao, Wen-Long Hu, Min-Min Wu, Li-Yan Jiang
Polycystic ovary syndrome (PCOS) is a prevalent endocrinological disorder in reproductive-age women and is often associated with a metabolic syndrome. To investigate whether exercise intervention promotes PCOS prevention, a rat model was used. Polycystic ovary syndrome was induced by letrozole administration, and animals presented with obesity, sex hormone disorder, no ovulation, large cystic follicles, and increasing fasting insulin (FINS) and leptin levels. The intervention was set at 3 different intensities of swimming exercise: low (0...
July 12, 2016: Reproductive Sciences
Nidhi Gupta, Marwan Zidan, Kathleen Moltz, Amita Adhikari, Colleen Buggs-Saxton, Hanaa Zidan, Dania Abushanab, Aida Lteif, Chandra Edwin
OBJECTIVE: While there is a general agreement that patient education is essential for compliance, no objective tools exist to assess knowledge of children and parents of children with endocrine disorders. We aimed to design and validate a Pediatric Endocrine Knowledge Assessment Questionnaire (PEKAQ) for congenital hypothyroidism, Hashimoto's thyroiditis, isolated growth hormone deficiency, Graves' disease and congenital adrenal hyperplasia. We evaluated baseline knowledge of children and parents of children with these disorders and assessed impact of educational intervention...
June 29, 2016: Journal of Clinical Research in Pediatric Endocrinology
Alon Eliakim
In recent years there has been a remarkable enhancement in the knowledge and understanding of endocrine responses to exercise and exercise training in children and adolescents who participate in sports. This includes, for example, exercise-associated changes in growth factors that regulate muscle adaptations to exercise training, the use of hormonal changes to assess training intensity, as well as deleterious effects of competitive sports, in particularly if associated with inadequate nutrition, on growth and the reproductive system...
May 2016: Pediatric Exercise Science
Rainer Rauramaa, Katriina Kukkonen-Harjula, Jari Arokoski, Hannele Hohtari, Eeva Ketola, Jyrki Kettunen, Pirjo Komulainen, Urho Kujala, Jari Laukkanen, Liisa Pylkkänen, Salla Savela, Kai Savonen, Heikki Tikkanen
The purpose of the guideline is to promote physical activity in the prevention, treatment and rehabilitation of diseases. Physical activity plays a key role in the management of several chronic noncommunicable diseases. In this guideline, the following diseases are discussed: endocrinological, cardiovascular, musculoskeletal and respiratory diseases, as well as depression and cancer. In addition, physical activity during pregnancy and in senior citizens is reviewed. Exercise counseling should be included as part of disease management and lifestyle guidance...
2016: Duodecim; Lääketieteellinen Aikakauskirja
Yehuda Handelsman, Robert R Henry, Zachary T Bloomgarden, Sam Dagogo-Jack, Ralph A DeFronzo, Daniel Einhorn, Ele Ferrannini, Vivian A Fonseca, Alan J Garber, George Grunberger, Derek LeRoith, Guillermo E Umpierrez, Matthew R Weir
AACE = American Association of Clinical Endocrinologists ACE = American College of Endocrinology DKA = diabetic ketoacidosis EMA = European Medicines Agency FDA = U.S. Food and Drug Administration SGLT-2 = sodium glucosecotransporter 2 T1D = type 1 diabetes T2D = type 2 diabetes.
June 2016: Endocrine Practice
Alon Eliakim
No abstract text is available yet for this article.
February 2016: Pediatric Exercise Science
Selim Sanel, Gulbuz Sezgin, Nesrin Sarıman, Ender Ugutmen, Can Solakoglu
INTRODUCTION: Bilateral proximal femoral fractures without trauma are very rare conditions. They have been reported in connection with osteoporosis, renal osteodystrophy, parathyroid disease, tumors, epileptic seizures, electroconvulsive therapy, and postirradiation. METHOD: We present a case of a 75-year-old man with bilateral hip fractures. No trauma, neurological, endocrinological disorder, or malignancy was reported in his history. He had a background of chronic obstructive pulmonary disease (COPD) and had been taking inhaled steroids (budesonide) 800 µg per day for 10 years...
2016: Archives of Osteoporosis
Jillian Inouye, Dongmei Li, James Davis, Richard Arakaki
Asian Americans and Pacific Islanders are twice as likely to be diagnosed with type 2 diabetes compared to Caucasians. The objective was to determine the effect of cognitive behavioral therapy on quality of life, general health perceptions, depressive symptoms, and glycemia in Asians and Pacific Islanders with type 2 diabetes. The design was a randomized controlled clinical trial comparing cognitive behavioral therapy to diabetes education and support for six weekly sessions. Participants were recruited from two endocrinology practices; 207 were enrolled...
November 2015: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
Yehuda Handelsman
OBJECTIVE: Following the first Food and Drug Administration (FDA) approval in 2013, sodium glucose cotransporter 2 (SGLT2) inhibitors have generated much interest among physicians treating patients with type 2 diabetes mellitus (T2DM). Here, the role in treatment with this drug class is considered in the context of T2DM treatment paradigms. METHODS: The clinical trials for the SGLT2 inhibitors are examined with a focus on canagliflozin, dapagliflozin, and empagliflozin...
September 2015: Endocrine Practice
Bruno Niederle, Jean-Louis Wémeau
A large majority of the currently diagnosed patients with hyperparathyroidism (PHPT) are mild or asymptomatic, mainly women after menopause. Following the debate held at the 16th European Congress of Endocrinology in Wroclaw (Poland) from May 3-7, 2014, arguments are here presented by a surgeon and a medical practitioner considering these situations rather have to profit from surgery, or simply from survey. For the trained endocrine surgeon, it is evident that parathyroidectomy confirms the diagnosis and undoubtedly reduces the discomfort felt by certain patients, prevents all risks of complications, removes patients and medical teams from the monitoring and represents a real individual financial benefit...
September 2015: European Journal of Endocrinology
Vrinda Saraff, Wolfgang Högler
Osteoporosis in children can be primary or secondary due to chronic disease. Awareness among paediatricians is vital to identify patients at risk of developing osteoporosis. Previous fractures and backaches are clinical predictors, and low cortical thickness and low bone density are radiological predictors of fractures. Osteogenesis Imperfecta (OI) is a rare disease and should be managed in tertiary paediatric units with the necessary multidisciplinary expertise. Modern OI management focuses on functional outcomes rather than just improving bone mineral density...
December 2015: European Journal of Endocrinology
Vidhu Thaker, Alexandra L Haagensen, Ben Carter, Zbys Fedorowicz, Brian W Houston
BACKGROUND: Cystic fibrosis is an inherited condition causing disease most noticeably in the lungs, digestive tract and pancreas. People with cystic fibrosis often have malnutrition and growth delay. Adequate nutritional supplementation does not improve growth optimally and hence an anabolic agent, recombinant growth hormone, has been proposed as a potential intervention. OBJECTIVES: To evaluate the effectiveness and safety of recombinant human growth hormone therapy in improving lung function, quality of life and clinical status of children and young adults with cystic fibrosis...
2015: Cochrane Database of Systematic Reviews
J Liu
Irisin is a newly discovered 112 amino acid residues' glycosylated protein hormone that was firstly found up-regulated by exercise-induced peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1α) and then play an important role in circulation so as to target other organs. It conducts many downstream events including osteoblast differentiation, nerve cell and β-cell regeneration and so on. In clinical research, non-inflammation and inflammation related diseases correlated with basal level of irisin and they benefited from exercise-induced irisin endocrinology...
2015: European Review for Medical and Pharmacological Sciences
Caroline M Apovian, Louis J Aronne, Daniel H Bessesen, Marie E McDonnell, M Hassan Murad, Uberto Pagotto, Donna H Ryan, Christopher D Still
OBJECTIVE: To formulate clinical practice guidelines for the pharmacological management of obesity. PARTICIPANTS: An Endocrine Society-appointed Task Force of experts, a methodologist, and a medical writer. This guideline was co-sponsored by the European Society of Endocrinology and The Obesity Society. EVIDENCE: This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe the strength of recommendations and the quality of evidence...
February 2015: Journal of Clinical Endocrinology and Metabolism
Ana Lilia Rodríguez-Ventura, Ingris Pelaez-Ballestas, Reyna Sámano-Sámano, Carlos Jimenez-Gutierrez, Carlos Aguilar-Salinas
INTRODUCTION: There are not enough studies about the barriers to lose weight from the perspective of children and their parents. METHODS: Children and adolescents diagnosed with overweight/obesity in the Department of Endocrinology and their parents were invited to participate in a series of focus group discussions (FGD). Twenty-nine children 10-16 years old and 22 parents participated in 7 focus groups; 2 mothers and 2 adolescents participated in depth interviews...
2014: Journal of Obesity
C B O'Leary, A C Hackney
The biosynthesis and metabolism of testosterone and cortisol are altered by the high levels of adipose tissue and the constant state of low-grade inflammation of obesity. Resistance exercise (REx) has become one of the main lifestyle interventions prescribed to obese individuals due to its ability to positively influence body composition and some biomarkers, such as cholesterol and insulin resistance. Yet, little research has been done in obese examining the effects of REx on the testosterone and blood cortisol responses, two integral hormones in both exercise and obesity...
2014: Physiological Research
Chia-Liang Tsai, Chun-Hao Wang, Chien-Yu Pan, Fu-Chen Chen, Tsang-Hai Huang, Feng-Ying Chou
First, to explore the effects of acute resistance exercise (RE, i.e., using exercise machines to contract and stretch muscles) on behavioral and electrophysiological performance when performing a cognitive task involving executive functioning in young male adults; Second, to investigate the potential biochemical mechanisms of such facilitative effects using two neurotrophic factors [i.e., growth hormone (GH) and insulin-like growth factor-1 (IGF-1)] and the cortisol levels elicited by such an exercise intervention mode with two different exercise intensities...
2014: Frontiers in Behavioral Neuroscience
Menno Henselmans, Brad J Schoenfeld
Due to a scarcity of longitudinal trials directly measuring changes in muscle girth, previous recommendations for inter-set rest intervals in resistance training programs designed to stimulate muscular hypertrophy were primarily based on the post-exercise endocrinological response and other mechanisms theoretically related to muscle growth. New research regarding the effects of inter-set rest interval manipulation on resistance training-induced muscular hypertrophy is reviewed here to evaluate current practices and provide directions for future research...
December 2014: Sports Medicine
Samer Hammoudeh, Abdulbari Bener, Mahmoud Zirie, Abdullah Al-Hamaq, Prem Chandra, Olivia Moses, Hildemar Dos Santos, Serena Tonstad
Metabolic syndrome is a cluster of metabolic abnormalities that increases the risk of cardiovascular disease and type 2 diabetes. Total human energy expenditure is divided into three major components; resting metabolic rate, thermic effect of food, and activity thermogenesis which is divided into exercise and non exercise activity thermogenesis (NEAT). In this study, NEAT was used as a lifestyle intervention on subjects with metabolic syndrome. 200 eligible patients from the Diabetes and Endocrinology Department at Hamad Medical Hospital in Doha, Qatar were assigned to an intervention (n = 100) or control (n = 100) group and followed for one year...
2013: Qatar Medical Journal
Antonio García-Hermoso, Jose M Saavedra, Yolanda Escalante, Mairena Sánchez-López, Vicente Martínez-Vizcaíno
OBJECTIVE: The purpose of this meta-analysis was to examine the evidence for the effectiveness of aerobic exercise interventions on reducing insulin resistance markers in obese children and/or adolescents. A secondary outcome was change in percentage of body fat. METHODS: A computerized search was made from seven databases: CINAHL, Cochrane Central Register of Controlled Trials, EMBASE, ERIC, MEDLINE, PsycINFO, and Science Citation Index. The analysis was restricted to randomized controlled trials that examined the effect of aerobic exercise on insulin resistance markers in obese youth...
October 2014: European Journal of Endocrinology
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