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https://www.readbyqxmd.com/read/27907931/-koronararterienanomalien-diagnostik-und-klassifikation-auf-basis-der-ct-und-mrt-des-herzens-von-alcapa-bis-terminationsanomaliecoronary-artery-anomalies-diagnosis-and-classification-based-on-cardiac-ct-and-mri-cmr-from-alcapa-to-anomalies-of-termination
#1
Philipp Heermann, Walter Heindel, Christoph Schülke
Background Coronary artery anomalies encompass a clinically and anatomically variable spectrum including physiological variants and pathophysiologically relevant anomalies. The majority of the variants has no hemodynamic relevance and is often detected accidentally. The recognition of the rare and relevant anomalies that cause either relevant shunt volumes leading to myocardial ischemia or ventricular tachyarrhythmias with the risk of sudden cardiac death is of major importance. Methods This review is based on a literature search in PubMed conducted using the key words "coronary artery" and/or "anomaly" and/or "anomalous origin" and/or "myocardial bridging" and/or "coronary artery fistula" and/or "Bland-White-Garland" and/or "ALCAPA"...
December 1, 2016: RöFo: Fortschritte Auf Dem Gebiete der Röntgenstrahlen und der Nuklearmedizin
https://www.readbyqxmd.com/read/27906065/dystrophin-deficient-dogs-with-reduced-myostatin-have-unequal-muscle-growth-and-greater-joint-contractures
#2
Joe N Kornegay, Daniel J Bogan, Janet R Bogan, Jennifer L Dow, Jiahui Wang, Zheng Fan, Naili Liu, Leigh C Warsing, Robert W Grange, Mihye Ahn, Cynthia J Balog-Alvarez, Steven W Cotten, Monte S Willis, Candice Brinkmeyer-Langford, Hongtu Zhu, Joe Palandra, Carl A Morris, Martin A Styner, Kathryn R Wagner
BACKGROUND: Myostatin (Mstn) is a negative regulator of muscle growth whose inhibition promotes muscle growth and regeneration. Dystrophin-deficient mdx mice in which myostatin is knocked out or inhibited postnatally have a less severe phenotype with greater total mass and strength and less fibrosis and fatty replacement of muscles than mdx mice with wild-type myostatin expression. Dogs with golden retriever muscular dystrophy (GRMD) have previously been noted to have increased muscle mass and reduced fibrosis after systemic postnatal myostatin inhibition...
April 4, 2016: Skeletal Muscle
https://www.readbyqxmd.com/read/27903782/the-assessment-of-grip-strength-after-upper-limb-injuries-in-medico-legal-practice
#3
Hjcr Belcher
Four hundred adult claimants underwent medico-legal assessment following upper limb injuries. Dynamometry was performed on each using the Jamar five handle-position test. Injury causes loss of power and there is a significant relationship between the percentage loss of power and the measured whole limb impairment. This paper presents a new approach for the analysis of the tests. The normal physiological length-tension pattern of muscle is maintained in the majority of claimants albeit with modifications due to the specific effects of injury on hand function...
November 30, 2016: Medico-legal Journal
https://www.readbyqxmd.com/read/27903588/discovery-and-validation-of-agonistic-angiotensin-receptor-autoantibodies-as-biomarkers-of-adverse-outcomes
#4
Peter Abadir, Alka Jain, Laura Powell, Qian-Li Xue, Jing Tian, Robert G Hamilton, David Bennett, Thomas Finucane, Jeremy D Walston, Neal S Fedarko
BACKGROUND: -Agonistic angiotensin II type I receptor autoantibodies (AT1RaAbs) have not been associated with functional measures or risk for adverse health outcomes. AT1RaAbs could be utilized to stratify patient risk and to identify patients who can benefit from angiotensin receptor blocker (ARB) treatment. METHODS: -Demographic and physiologic covariates were measured in a discovery set of community dwelling adults from Baltimore (N=255) and AT1RaAb associations with physical function tests and outcomes assessed...
November 30, 2016: Circulation
https://www.readbyqxmd.com/read/27902841/dynamical-effects-of-calcium-sensitive-potassium-currents-on-voltage-and-calcium-alternans
#5
Matthew Kennedy, Donald M Bers, Nipavan Chiamvimonvat, Daisuke Sato
Cardiac alternans is a precursor to life-threatening arrhythmias. Alternans can be caused by instability of the membrane voltage (Vm ), instability of the intracellular Ca (Cai ) cycling, or both. Vm dynamics and Cai dynamics are coupled via Ca-sensitive currents. In cardiac myocytes, there are several Ca-sensitive potassium (K) currents such as the slowly activating delayed rectifier current (IKs ) and the small conductance Ca-activated potassium (SK) current (ISK ). However, the role of these currents in the development of arrhythmias is not well understood...
November 30, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27901338/determinant-factors-of-peak-treadmill-speed-in-physically-active-men
#6
Leonardo Alves Pasqua, Mayara V Damasceno, Salomão Bueno, Alessandro M Zagatto, Gustavo G DE Araújo, Adriano E Lima-Silva, Rômulo Bertuzzi
BACKGROUND: The aim of the present study was to determine whether physiological factors and maximal dynamic strength are able to determine the peak treadmill speed (PTS) in physically active individuals. METHODS: One hundred and fifty physically active healthy males voluntarily visit the laboratory on three separate occasions and underwent the following activities: first visit: IPAQ (short version), anthropometric measurements, and a maximal incremental test performed for physiological variables (maximal oxygen uptake ( ) and respiratory compensation point (RCP); second visit: constant speed test for running economy (RE) measurement, and familiarization with the maximum dynamic strength (1RM) test in the leg press exercise; third visit: 1RM test...
November 30, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27898678/leukocyte-telomere-length-in-relation-to-17-biomarkers-of-cardiovascular-disease-risk-a-cross-sectional-study-of-us-adults
#7
David H Rehkopf, Belinda L Needham, Jue Lin, Elizabeth H Blackburn, Ami R Zota, Janet M Wojcicki, Elissa S Epel
BACKGROUND: Leukocyte telomere length (LTL) is a putative biological marker of immune system age, and there are demonstrated associations between LTL and cardiovascular disease. This may be due in part to the relationship of LTL with other biomarkers associated with cardiovascular disease risk. However, the strength of associations between LTL and adiposity, metabolic, proinflammatory, and cardiovascular biomarkers has not been systematically evaluated in a United States nationally representative population...
November 2016: PLoS Medicine
https://www.readbyqxmd.com/read/27896146/determination-of-functional-prognosis-in-hospitalized-patients-following-an-intensive-care-admission
#8
Natália A Ferreira, Agnaldo José Lopes, Arthur S Ferreira, George Ntoumenopoulos, Jerffesson Dias, Fernando S Guimaraes
AIM: To investigate the factors associated with the functional progress of hospitalized patients following an intensive care admission. METHODS: Retrospective study including data from a cohort of 198 hospitalized patients following an intensive care admission and not requiring mechanical ventilation in a single tertiary referral hospital. A generalized linear model was used to identify the main effects of clinical and demographic variables on the outcomes of functionality (KATZ Index of Independence in Activities of Daily Living) and muscle strength (MRC Scale)...
November 4, 2016: World Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/27895872/investigation-of-factors-affecting-body-temperature-changes-during-routine-clinical-head-magnetic-resonance-imaging
#9
Myeong Seong Kim
BACKGROUND: Pulsed radiofrequency (RF) magnetic fields, required to produce magnetic resonance imaging (MRI) signals from tissue during the MRI procedure have been shown to heat tissues. OBJECTIVES: To investigate the relationship between body temperature rise and the RF power deposited during routine clinical MRI procedures, and to determine the correlation between this effect and the body's physiological response. PATIENTS AND METHODS: We investigated 69 patients from the Korean national cancer center to identify the main factors that contribute to an increase in body temperature (external factors and the body's response) during a clinical brain MRI...
October 2016: Iranian Journal of Radiology: a Quarterly Journal Published By the Iranian Radiological Society
https://www.readbyqxmd.com/read/27895559/reorganization-of-visual-callosal-connections-following-alterations-of-retinal-input-and-brain-damage
#10
REVIEW
Laura Restani, Matteo Caleo
Vision is a very important sensory modality in humans. Visual disorders are numerous and arising from diverse and complex causes. Deficits in visual function are highly disabling from a social point of view and in addition cause a considerable economic burden. For all these reasons there is an intense effort by the scientific community to gather knowledge on visual deficit mechanisms and to find possible new strategies for recovery and treatment. In this review, we focus on an important and sometimes neglected player of the visual function, the corpus callosum (CC)...
2016: Frontiers in Systems Neuroscience
https://www.readbyqxmd.com/read/27893850/a-convenient-in-vivo-model-using-small-interfering-rna-silencing-to-rapidly-assess-skeletal-gene-function
#11
Wen Zhang, Can Liu, Bao Hai, Guohong Du, Hong Wang, Huijie Leng, Yingsheng Xu, Chunli Song
It is difficult to study bone in vitro because it contains various cell types that engage in cross-talk. Bone biologically links various organs, and it has thus become increasingly evident that skeletal physiology must be studied in an integrative manner in an intact animal. We developed a model using local intraosseous small interfering RNA (siRNA) injection to rapidly assess the effects of a target gene on the local skeletal environment. In this model, 160-g male Sprague-Dawley rats were treated for 1-2 weeks...
2016: PloS One
https://www.readbyqxmd.com/read/27892550/multifunctional-and-robust-composite-materials-comprising-gold-nanoparticles-at-a-spherical-polystyrene-particle-surface
#12
Samir A Belhout, Ji Yoon Kim, David T Hinds, Natalie J Owen, Jonathan A Coulter, Susan J Quinn
The preparation of a family of composite particles comprising gold nanoparticles (AuNP) assembled at a polystyrene (PS) surface is reported. Tunable loading is demonstrated for AuNP sizes (4.5-26 nm). The robust composites are stable to multiple centrifugation and dispersion cycles and to conditions of high ionic strength, physiological buffer and cell culture media. These properties provide potential for a variety of applications from cellular studies to catalysis.
November 28, 2016: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/27889916/precipitation-alters-interactions-in-a-grassland-ecological-community
#13
Nicolas Deguines, Justin S Brashares, Laura R Prugh
1.Climate change is transforming precipitation regimes worldwide. Changes in precipitation regimes are known to have powerful effects on plant productivity, but the consequences of these shifts for the dynamics of ecological communities are poorly understood. This knowledge gap hinders our ability to anticipate and mitigate the impacts of climate change on biodiversity. 2.Precipitation may affect fauna through direct effects on physiology, behavior or demography, through plant-mediated indirect effects, or by modifying interactions among species...
November 27, 2016: Journal of Animal Ecology
https://www.readbyqxmd.com/read/27889072/if-euhydric-and-isotonic-do-not-work-what-are-acceptable-ph-and-osmolality-for-parenteral-drug-dosage-forms
#14
REVIEW
Dieter Roethlisberger, Hanns-Christian Mahler, Ulrike Altenburger, Astrid Pappenberger
Parenteral products should aim toward being isotonic and euhydric (physiological pH). Yet, due to other considerations, this goal is often not reasonable or doable. There are no clear allowable ranges related to pH and osmolality, and thus, the objective of this review was to provide a better understanding of acceptable formulation pH, buffer strength, and osmolality taking into account the administration route (i.e., intramuscular, intravenous, subcutaneous) and administration technique (i.e., bolus, push, infusion)...
November 23, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27887984/impact-of-%C3%AE-hydroxy-%C3%AE-methylbutyrate-hmb-on-age-related-functional-deficits-in-mice
#15
Michael Munroe, Yair Pincu, Jennifer Merritt, Adam Cobert, Ryan Brander, Tor Jensen, Justin Rhodes, Marni D Boppart
β-Hydroxy β-methylbutyrate (HMB) is a metabolite of the essential amino acid leucine. Recent studies demonstrate a decline in plasma HMB concentrations in humans across the lifespan, and HMB supplementation may be able to preserve muscle mass and strength in older adults. However, the impact of HMB supplementation on hippocampal neurogenesis and cognition remains largely unexplored. The purpose of this study was to simultaneously evaluate the impact of HMB on muscle strength, neurogenesis and cognition in young and aged mice...
November 22, 2016: Experimental Gerontology
https://www.readbyqxmd.com/read/27885332/2-3-5-4-tetrahydroxystilbene-2-o-%C3%AE-d-glucoside-promotes-expression-of-the-longevity-gene-klotho
#16
Shuang Ling, Ju Duan, Rongzhen Ni, Jin-Wen Xu
The longevity gene klotho has numerous physiological functions, such as regulating calcium and phosphorus levels, delaying senescence, improving cognition, reducing oxidative stress, and protecting vascular endothelial cells. This study tested whether 2,3,5,4'-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG), a small molecule with antiaging effects, regulates the expression and physiological effects of klotho. Our results showed that THSG dose-dependently increased the luciferase reporter activity of the klotho gene, reversed the decrease in mRNA and protein expression of klotho which was induced by angiotensin II in NRK-52E renal tubular epithelial cells, and increased klotho mRNA expression in the cerebral cortex, hippocampus, testis, and kidney medulla of spontaneously hypertensive rats...
2016: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/27882916/spirometry-improvement-after-muscular-exercise-in-elite-swimmers
#17
Alessandro Rubini, Alex Rizzato, Simone Fava, Nicola Olivato, Devanand Mangar, Enrico M Camporesi, Gerardo Bosco
BACKGROUND: An increased sympathetic activity during muscular effort is a well established physiological response, whose intensity is known to increase with the muscular load. Spirometry was described to improve as an effect of swimming training in healthy and asthmatic subjects, suggesting a decrease in airway resistance The aim was to investigate the possible effect of muscular exercise (swimming) on spirometry, in particular searching for possible differences because of different swimming times...
November 24, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27881775/a-biophysical-model-for-cytotoxic-cell-swelling
#18
Koen Dijkstra, Jeannette Hofmeijer, Stephan A van Gils, Michel J A M van Putten
: We present a dynamic biophysical model to explain neuronal swelling underlying cytotoxic edema in conditions of low energy supply, as observed in cerebral ischemia. Our model contains Hodgkin-Huxley-type ion currents, a recently discovered voltage-gated chloride flux through the ion exchanger SLC26A11, active KCC2-mediated chloride extrusion, and ATP-dependent pumps. The model predicts changes in ion gradients and cell swelling during ischemia of various severity or channel blockage with realistic timescales...
November 23, 2016: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/27881573/intestinal-na-k-2cl-cotransporter-2-plays-a-crucial-role-in-hyperosmotic-transitions-of-a-euryhaline-teleost
#19
Andrew J Esbaugh, Brett Cutler
Euryhaline fishes, such as the red drum (Sciaenops ocellatus), must quickly transition between hyperosmotic and hypoosmotic physiological strategies. When freshwater individuals transition to seawater they are exposed to increased diffusive water loss and ion gain. To maintain osmoregulatory balance these animals must drink and absorb seawater through the intestine, followed by ion excretion at the gills. The ability of fishes to transition between strategies can limit the magnitude of osmotic shock that can be tolerated...
November 2016: Physiological Reports
https://www.readbyqxmd.com/read/27876024/evaluation-of-computer-based-computer-tomography-stratification-against-outcome-models-in-connective-tissue-disease-related-interstitial-lung-disease-a-patient-outcome-study
#20
Joseph Jacob, Brian J Bartholmai, Srinivasan Rajagopalan, Anne Laure Brun, Ryoko Egashira, Ronald Karwoski, Maria Kokosi, Athol U Wells, David M Hansell
BACKGROUND: To evaluate computer-based computer tomography (CT) analysis (CALIPER) against visual CT scoring and pulmonary function tests (PFTs) when predicting mortality in patients with connective tissue disease-related interstitial lung disease (CTD-ILD). To identify outcome differences between distinct CTD-ILD groups derived following automated stratification of CALIPER variables. METHODS: A total of 203 consecutive patients with assorted CTD-ILDs had CT parenchymal patterns evaluated by CALIPER and visual CT scoring: honeycombing, reticular pattern, ground glass opacities, pulmonary vessel volume, emphysema, and traction bronchiectasis...
November 23, 2016: BMC Medicine
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