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https://www.readbyqxmd.com/read/28933715/rating-of-perceived-exertion-for-quantification-of-training-and-combat-loads-during-combat-sport-specific-activities-a-short-review
#1
Maamer Slimani, Philip Davis, Emerson Franchini, Wassim Moalla
Slimani, M, Davis, P, Franchini, E, and Moalla, W. Rating of perceived exertion for quantification of training and combat loads during combat sport-specific activities: a short review. J Strength Cond Res 31(10): 2889-2902, 2017-The aim of this short review was to summarize data pertaining to the rating of perceived exertion (RPE) methods (RPE value and session-RPE) during combat sport-specific activities (i.e., competition and training) based on many factors, including contest type (i.e., official vs. simulated vs...
October 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28933710/elite-youth-soccer-players-physiological-responses-time-motion-characteristics-and-game-performance-in-4-vs-4-small-sided-games-the-influence-of-coach-feedback
#2
Mirko Brandes, Sebastian Elvers
Brandes, M and Elvers, S. Elite youth soccer players' physiological responses, time-motion characteristics, and game performance in 4 vs. 4 small-sided games: the influence of coach feedback. J Strength Cond Res 31(10): 2652-2658, 2017-The purpose of this study was to determine the impact of mild vs. strongly pushed coach feedback on the physiological response, ratio of perceived exertion (RPE), and time-motion characteristics in soccer training with small-sided games (SSGs). Sixteen elite youth soccer players (aged 17...
October 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28930474/unveiling-the-self-assembling-behavior-of-5-fluorouracil-and-its-n-n-dimethyl-derivative-a-spectroscopic-and-microscopic-approach
#3
Pavel Banerjee, Devdeep Mukherjee, Tapas Kumar Maiti, Nilmoni Sarkar
At physiological conditions, 5-fluorouracil (5-FU), an anti-cancer drug self-assembles into fibrils by strong hydrogen bonding network while its methylated derivative, 5-fluoro-1,3-dimethyluracil (5-FDMU) do not make fibril due to lack of strong hydrogen bonding motif. In vitro, 5-FU self-assembly is sensitive to physicochemical conditions like the pH and ionic strength of the solution, which tune the strength of the non-covalent driving forces. Here we report a surprising finding that the buffer-which is necessary to control the pH and is typically considered to be inert-also significantly, influences 5-FU self-assembly which indicates an important role of counter-ions in the fibril formation...
September 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28930428/ion-transport-in-confined-geometries-below-the-nanoscale-access-resistance-dominates-protein-channel-conductance-in-diluted-solutions
#4
Antonio Alcaraz, M Lidón López, María Queralt-Martín, Vicente M Aguilella
Synthetic nanopores and mesoscopic protein channels have common traits like the importance of electrostatic interactions between the permeating ions and the nanochannel. Ion transport at the nanoscale occurs under confinement conditions so that the usual assumptions made in microfluidics are challenged, among others, by interfacial effects such as access resistance (AR). Here we show that a sound interpretation of electrophysiological measurements in terms of channel ion selective properties requires the consideration of interfacial effects, up to the point that they dominate protein channel conductance in diluted solutions...
September 20, 2017: ACS Nano
https://www.readbyqxmd.com/read/28929959/-in-vitro-effect-of-vancomycin-and-daptomycin-on-biofilm-formation-of-coagulase-negative-staphylococci-strains
#5
Duygu Nilüfer Öcal, İştar Dolapçı, Zeynep Gençtürk, Alper Tekeli
Coagulase-negative staphylococci (CNS) are one of the primer agents of blood stream infections (BSI) and catheter-related bloodstream infections (CR-BSI) which are associated mostly with the usage of central venous catheters and, important causes of morbidity and mortality despite the usage of antibacterial and supportive treatment. It is important to determine the properties of these causative microorganisms in order to make appropriate treatment of such infections. The aims of our study were to evaluate the biofilm formation of coagulase negative staphylococci (CNS) which were causative agents of bloodstream (BSI) and catheter related bloodstream infections (CR-BSI), to determine the minimum inhibitory concentration (MIC) of planktonic forms and minimal biofilm eradication concentration (MBEC) of sessile forms for vancomycin and daptomycin and to evaluate the efficacy of these antibiotics in infections with biofilm-forming isolates in vitro...
July 2017: Mikrobiyoloji Bülteni
https://www.readbyqxmd.com/read/28928636/smn-deficiency-increases-the-intrinsic-excitability-of-motoneurons
#6
Saravanan Arumugam, Ana Garcera, Rosa M Soler, Lucía Tabares
During development, motoneurons experience significant changes in their size and in the number and strength of connections that they receive, which requires adaptive changes in their passive and active electrical properties. Even after reaching maturity, motoneurons continue to adjust their intrinsic excitability and synaptic activity for proper functioning of the sensorimotor circuit in accordance with physiological demands. Likewise, if some elements of the circuit become dysfunctional, the system tries to compensate for the alterations to maintain appropriate function...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28927943/laser-microdissection-a-powerful-tool-for-genomics-at-cell-level
#7
REVIEW
Claudia Bevilacqua, Bertrand Ducos
Laser microdissection (LM) has become considerably democratized over the last fifteen years. Instruments have evolved to offer more powerful and efficient lasers as well as new options for sample collection and preparation. Technological evolutions have also focused on the post-microdissection analysis capabilities, opening up investigations in all disciplines of experimental and clinical biology, thanks to the advent of new high-throughput methods of genome analysis, including RNAseq and proteomics, now globally known as microgenomics, i...
September 16, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/28927930/biodegradable-and-adjustable-sol-gel-glass-based-hybrid-scaffolds-from-multi-armed-oligomeric-building-blocks
#8
Christian Kascholke, Stephan Hendrikx, Tobias Flath, Dzmitry Kuzmenka, Hans-Martin Dörfler, Dirk Schumann, Mathias Gressenbuch, F Peter Schulze, Michaela Schulz-Siegmund, Michael C Hacker
Biodegradability is a crucial characteristic to improve the clinical potential of sol-gel-derived glass materials. To this end, a set of degradable organic/inorganic class II hybrids from a tetraethoxysilane(TEOS)-derived silica sol and oligovalent cross-linker oligomers containing oligo(D,L-lactide) domains was developed and characterized. A series of 18 oligomers (Mn: 1100-3200 Da) with different degrees of ethoxylation and varying length of oligoester units was established and chemical composition was determined...
September 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28926772/ultrasound-assisted-interaction-between-chlorin-e6-and-human-serum-albumin-ph-dependence-singlet-oxygen-production-and-formulation-effect
#9
Mihaela N Mocanu, Fei Yan
The interaction between chlorin e6 (Ce6) and human serum albumin (HSA) in the presence and absence of ultrasound have been investigated by ultraviolet-visible absorption spectroscopy and fluorescence spectroscopy. Ce6 is found to bind strongly to HSA at or near physiological pH conditions, but the strength of the binding is significantly weakened at lower pHs. The intrinsic fluorescence of HSA is incrementally quenched with increasing concentration of Ce6, and the quenching is enhanced after exposure to high-frequency ultrasound...
September 13, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28925341/physiological-attunement-in-mother-infant-dyads-at-clinical-high-risk-the-influence-of-maternal-depression-and-positive-parenting
#10
Cassandra L Hendrix, Zachary N Stowe, D Jeffrey Newport, Patricia A Brennan
A growing number of research studies have examined the intradyadic coregulation (or attunement) of hypothalamus-pituitary-adrenal axis functioning in mothers and their children. However, it is unclear how early this coregulation may be present in dyads at clinical high risk and whether certain factors, such as maternal depression or positive parenting, are associated with the strength of this coregulation. The present study examined cortisol attunement within mother-infant dyads in a high-risk sample of 233 mothers who received treatment for psychiatric illness during pregnancy and whose infants were 6 months old at the study visit...
September 19, 2017: Development and Psychopathology
https://www.readbyqxmd.com/read/28919258/examining-the-time-course-of-genital-and-subjective-sexual-responses-in-women-and-men-with-concurrent-plethysmography-and-thermography
#11
Jackie S Huberman, Samantha J Dawson, Meredith L Chivers
Sexual response is a dynamic process, though there is limited knowledge of the time course and relationships among its psychological and physiological components. To address this gap, we concurrently assessed self-reported sexual arousal, genital temperature (with thermography), and genital vasocongestion (with vaginal photoplethysmography [VPP] or penile plethysmography [PPG]) during sexual and nonsexual films in 28 androphilic women (attracted to men) and 27 gynephilic men (attracted to women). Men and women had similarly strong agreement between subjective and genital responses (sexual concordance) with thermography, but this agreement was stronger in men than women with PPG/VPP...
September 14, 2017: Biological Psychology
https://www.readbyqxmd.com/read/28918566/understanding-the-science-of-resistance-training-an-evolutionary-perspective
#12
William J Kraemer, Nicholas A Ratamess, Shawn D Flanagan, Jason P Shurley, Janice S Todd, Terry C Todd
The history of resistance training research began with anecdotal ideas and a slow growth of research from the late 1890s through the 1970s. The mid-1970s were a nexus point when resistance training studies evolved from just strength assessments to importance in physiological systems, physical health, and physical performance capabilities for individuals interested in physical fitness through to those seeking elite athletic performances. The pursuit of understanding program design and what mediated successful programs continues today as new findings, replication of old concepts, and new visions with the latest technologies fuel both our understanding and interest in this modality...
September 16, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28917135/failing-to-learn-from-negative-prediction-errors-obesity-is-associated-with-alterations-in-a-fundamental-neural-learning-mechanism
#13
David Mathar, Jane Neumann, Arno Villringer, Annette Horstmann
Prediction errors (PEs) encode the difference between expected and actual action outcomes in the brain via dopaminergic modulation. Integration of these learning signals ensures efficient behavioral adaptation. Obesity has recently been linked to altered dopaminergic fronto-striatal circuits, thus implying impairments in cognitive domains that rely on its integrity. 28 obese and 30 lean human participants performed an implicit stimulus-response learning paradigm inside an fMRI scanner. Computational modeling and psycho-physiological interaction (PPI) analysis was utilized for assessing PE-related learning and associated functional connectivity...
August 24, 2017: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/28915923/season-but-not-symbiont-state-drives-microbiome-structure-in-the-temperate-coral-astrangia-poculata
#14
Koty H Sharp, Zoe A Pratte, Allison H Kerwin, Randi D Rotjan, Frank J Stewart
BACKGROUND: Understanding the associations among corals, their photosynthetic zooxanthella symbionts (Symbiodinium), and coral-associated prokaryotic microbiomes is critical for predicting the fidelity and strength of coral symbioses in the face of growing environmental threats. Most coral-microbiome associations are beneficial, yet the mechanisms that determine the composition of the coral microbiome remain largely unknown. Here, we characterized microbiome diversity in the temperate, facultatively symbiotic coral Astrangia poculata at four seasonal time points near the northernmost limit of the species range...
September 15, 2017: Microbiome
https://www.readbyqxmd.com/read/28914969/autocrine-and-paracrine-regulation-of-the-murine-skeleton-by-osteocyte-derived-parathyroid-hormone-related-protein
#15
Niloufar Ansari, Patricia W M Ho, Blessing Crimeen-Irwin, Ingrid J Poulton, Athena R Brunt, Mark R Forwood, Paola Divieti Pajevic, Jonathan H Gooi, T John Martin, Natalie A Sims
Parathyroid hormone related-protein (PTHrP) and parathyroid hormone (PTH) have N-terminal domains that bind a common receptor, PTHR1. N-terminal PTH (teriparatide) and now a modified N-terminal PTHrP (abaloparatide) are FDA-approved therapies for osteoporosis. In physiology, 00PTHrP does not normally circulate at significant levels, but acts locally and osteocytes, cells residing within the bone matrix, express both PTHrP and the PTHR1. Since PTHR1 in osteocytes is required for normal bone resorption, we determined how osteocyte-derived PTHrP influences the skeleton...
September 15, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28914603/synaptic-up-scaling-preserves-motor-circuit-output-after-chronic-natural-inactivity
#16
Joseph M Santin, Mauricio Vallejo, Lynn K Hartzler
Neural systems use homeostatic plasticity to maintain normal brain functions and to prevent abnormal activity.  Surprisingly, homeostatic mechanisms that regulate circuit output have mainly been demonstrated during artificial and/or pathological perturbations.  Natural, physiological scenarios that activate these stabilizing mechanisms in neural networks of mature animals remain elusive.  To establish the extent to which a naturally inactive circuit engages mechanisms of homeostatic plasticity, we utilized the respiratory motor circuit in bullfrogs that normally remains inactive for several months during the winter...
September 15, 2017: ELife
https://www.readbyqxmd.com/read/28910740/generation-of-low-gamma-oscillations-in-a-gabaergic-network-model-of-the-striatum
#17
Zhihua Wu, Aike Guo, Xiaodi Fu
Striatal oscillations in the low-gamma frequency range have been consistently recorded in a number of experimental studies. However, whether these rhythms are locally generated in the striatum circuit, which is mainly composed of GABAergic neurons, remains an open question. GABAergic medium spiny projection neurons represent the great majority of striatal neurons, but they fire at very low rates. GABAergic fast-spiking interneurons typically show firing rates that are approximately 10 times higher than those of principal neurons, but they are a very small minority of the total neuronal population...
September 11, 2017: Neural Networks: the Official Journal of the International Neural Network Society
https://www.readbyqxmd.com/read/28899822/early-strength-recovery-after-anterior-cruciate-ligament-reconstruction-using-the-fascia-lata
#18
Gregory Haillotte, Alexandre Hardy, Benjamin Granger, Thibaut Noailles, Fréderic Khiami
INTRODUCTION: After undergoing anterior cruciate ligament (ACL) reconstruction, patients must recover at least 80% of their hamstring and quadriceps strength to be able to return to sports without risk to the graft. Harvesting of the patellar tendon leads to large deficits in quadriceps strength, while harvesting the hamstring tendons leads to large deficits in hamstring strength. However, there are no published studies on the strength deficit after ACL reconstruction with the fascia lata...
September 9, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28899656/greater-ankle-strength-anaerobic-and-aerobic-capacity-and-agility-predict-ground-combat-military-occupational-school-graduation-in-female-marines
#19
Katelyn Fleishman Allison, Karen A Keenan, Meleesa F Wohleber, Katherine A Perlsweig, Erin R Pletcher, Mita Lovalekar, Kim Beals, Lawrence C Coleman, Bradley C Nindl
Women can serve in all military occupational specialties (MOS); however, musculoskeletal and physiological characteristics that predict successful completion of ground combat MOS schools by female Marines are unknown. OBJECTIVES: To determine which demographic, musculoskeletal, and physiological characteristics predict graduation from infantry and vehicle ground combat MOS schools in female Marines. DESIGN: Prospective cohort study. METHODS: Prior to MOS school, the following were assessed in 62 female Marines (22...
August 24, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28895772/flow-cytometry-based-platelet-function-testing-is-predictive-of-symptom-burden-in-a-cohort-of-bleeders
#20
Niklas Boknäs, Sofia Ramström, Lars Faxälv, Tomas L Lindahl
Platelet function disorders (PFDs) are common in patients with mild bleeding disorders (MBDs), yet the significance of laboratory findings suggestive of a PFD remain unclear due to the lack of evidence for a clinical correlation between the test results and the patient phenotype. Herein, we present the results from a study evaluating the potential utility of platelet function testing using whole-blood flow cytometry in a cohort of 105 patients undergoing investigation for MBD. Subjects were evaluated with a test panel comprising two different activation markers (fibrinogen binding and P-selectin exposure) and four physiologically relevant platelet agonists (ADP, PAR1-AP, PAR4-AP, and CRP-XL)...
September 12, 2017: Platelets
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