keyword
https://read.qxmd.com/read/38469726/exploring-the-significance-of-microbiota-metabolites-in-rheumatoid-arthritis-uncovering-their-contribution-from-disease-development-to-biomarker-potential
#21
REVIEW
Zi-Feng Lu, Chou-Yi Hsu, Nada Khairi Younis, Mohammed Ahmed Mustafa, Elena A Matveeva, Yassien Hussain Owaied Al-Juboory, Mohaned Adil, Zainab H Athab, Mustafa Nasrat Abdulraheem
Rheumatoid arthritis (RA) is a multifaceted autoimmune disorder characterized by chronic inflammation and joint destruction. Recent research has elucidated the intricate interplay between gut microbiota and RA pathogenesis, underscoring the role of microbiota-derived metabolites as pivotal contributors to disease development and progression. The human gut microbiota, comprising a vast array of microorganisms and their metabolic byproducts, plays a crucial role in maintaining immune homeostasis. Dysbiosis of this microbial community has been linked to numerous autoimmune disorders, including RA...
March 12, 2024: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://read.qxmd.com/read/38469309/comparative-analysis-of-swine-leukocyte-antigen-gene-diversity-in-g%C3%A3-ttingen-minipigs
#22
JOURNAL ARTICLE
Sabine E Hammer, Tereza Duckova, Monica Gociman, Sandra Groiss, Clara P S Pernold, Karolin Hacker, Lena Kasper, Julia Sprung, Maria Stadler, Andres Eskjær Jensen, Armin Saalmüller, Nadine Wenzel, Constanca Figueiredo
Worldwide, pigs represent economically important farm animals, also representing a preferred preclinical large animal model for biomedical studies. The need for swine leukocyte antigen (SLA) typing is increasing with the expanded use of pigs in translational research, infection studies, and for veterinary vaccine design. Göttingen Minipigs (GMP) attract increasing attention as valuable model for pharmacological studies and transplantation research. This study represents a first-time assessment of the SLA gene diversity in Göttingen Minipigs in combination with a comparative metadata analysis with commercial pig lines...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38469303/gene-edited-pigs-a-translational-model-for-human-food-allergy-against-alpha-gal-and-anaphylaxis
#23
JOURNAL ARTICLE
Ying Wang, Miriam Hils, Andrea Fischer, Florian Wölbing, Tilo Biedermann, Angelika Schnieke, Konrad Fischer
The prevalence of food allergy is rising and is estimated to approach 10%. Red meat allergy is the first known food allergy elicited by immunoglobulin E (IgE) antibodies recognizing a carbohydrate. Due to the loss of function of the alpha-1,3-galactosyltransferase ( GGTA1) gene in humans, the disaccharide galactose-α-1,3-galactose (α-Gal) cannot be synthesized and therefore became immunogenic. IgE sensitization is elicited through the skin by repetitive tick bites transmitting α-Gal. The underlying mechanisms regarding innate and adaptive immune cell activation, including the B-cell isotype switch to IgE, are poorly understood, requiring further research and physiologically relevant animal models...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38463658/unremitting-pro-inflammatory-t-cell-phenotypes-and%C3%A2-macrophage-activity-following-paediatric-burn-injury
#24
JOURNAL ARTICLE
Donna Langley, Kate Zimmermann, Emma Krenske, Giorgio Stefanutti, Roy M Kimble, Andrew Ja Holland, Mark W Fear, Fiona M Wood, Tony Kenna, Leila Cuttle
OBJECTIVES: The aim of this study was to characterise the dynamic immune profile of paediatric burn patients for up to 18 months post-burn. METHODS: Flow cytometry was used to measure 25 cell markers, chemokines and cytokines which reflected both pro-inflammatory and anti-inflammatory immune profiles. Peripheral blood mononuclear cells from 6 paediatric burn patients who had returned for repeated burn and scar treatments for > 4 timepoints within 12 months post-burn were compared to four age-matched healthy controls...
2024: Clinical & Translational Immunology
https://read.qxmd.com/read/38463578/cdca8-a-mitosis-related-gene-as-a-prospective-pan-cancer-biomarker-implications-for-survival-prognosis-and-oncogenic-immunology
#25
JOURNAL ARTICLE
Hanjie Hu, Muhammad Umair, Sikandar Ali Khan, Aliya Irshad Sani, Sahar Iqbal, Fatima Khalid, Rizwana Sultan, Mostafa A Abdel-Maksoud, Ayman Mubarak, Turki M Dawoud, Abdul Malik, Ibrahim A Saleh, Abdul Aziz Al Amri, Norah Khaled Algarzae, Ahmad S Kodous, Yasir Hameed
BACKGROUND: Human cell division cycle-associated protein 8 (CDCA8), a critical regulator of mitosis, has been identified as a prospective prognostic biomarker in several cancer types, including breast, colon, and lung cancers. This study analyzed the diagnostic/prognostic potential and clinical implications of CDCA8 across diverse cancers. METHODS: Bioinformatics and molecular experiments. RESULTS: Analyzing TCGA data via TIMER2 and GEPIA2 databases revealed significant up-regulation of CDCA8 in 23 cancer types compared to normal tissues...
2024: American Journal of Translational Research
https://read.qxmd.com/read/38462043/immune-cell-derived-extracellular-vesicles-for-precision-therapy-of-inflammatory-related-diseases
#26
REVIEW
Shuo Li, Wenqing Li, Xianggui Wu, Beiyuan Zhang, Lisha Liu, Lifang Yin
Inflammation-related diseases impose a significant global health burden, necessitating urgent exploration of novel treatment modalities for improved clinical outcomes. We begin by discussing the limitations of conventional approaches and underscore the pivotal involvement of immune cells in the inflammatory process. Amidst the rapid growth of immunology, the therapeutic potential of immune cell-derived extracellular vesicles (EVs) has garnered substantial attention due to their capacity to modulate inflammatory response...
March 8, 2024: Journal of Controlled Release
https://read.qxmd.com/read/38461145/circulating-immune-signatures-in-chronic-pancreatitis-with-and-without-preceding-acute-pancreatitis-a-pilot-study
#27
JOURNAL ARTICLE
Rasmus Hagn-Meincke, Dhiraj Yadav, Dana K Andersen, Santhi Swaroop Vege, Evan L Fogel, Jose Serrano, Melena D Bellin, Mark D Topazian, Darwin L Conwell, Liang Li, Stephen K Van Den Eeden, Asbjørn M Drewes, Stephen J Pandol, Chris E Forsmark, William E Fisher, Phil A Hart, Søren S Olesen, Walter G Park
OBJECTIVE: To investigate profiles of circulating immune signatures in healthy controls and chronic pancreatitis patients (CP) with and without a preceding history of acute pancreatitis (AP). METHODS: We performed a phase 1, cross-sectional analysis of prospectively collected serum samples from the PROspective Evaluation of Chronic Pancreatitis for EpidEmiologic and Translation StuDies (PROCEED) study. All samples were collected during a clinically quiescent phase...
February 28, 2024: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://read.qxmd.com/read/38458740/advances-in-rna-therapeutics-for-modulation-of-undruggable-targets
#28
JOURNAL ARTICLE
Emily Martinsen, Tasmia Jinnurine, Saranya Subramani, Marie Rogne
Over the past decades, drug discovery utilizing small pharmacological compounds, fragment-based therapeutics, and antibody therapy have significantly advanced treatment options for many human diseases. However, a major bottleneck has been that>70% of human proteins/genomic regions are 'undruggable' by the above-mentioned approaches. Many of these proteins constitute essential drug targets against complex multifactorial diseases like cancer, immunological disorders, and neurological diseases. Therefore, alternative approaches are required to target these proteins or genomic regions in human cells...
2024: Progress in Molecular Biology and Translational Science
https://read.qxmd.com/read/38458301/a-disintegrin-and-metalloproteinase-carves-t-cell-abnormalities-and-pathogenesis-in-systemic-lupus-erythematosus
#29
REVIEW
Masataka Umeda, Abhigyan Satyam, Nobuya Yoshida, Atsushi Kawakami
Systemic lupus erythematosus (SLE) is a complex autoimmune disorder impacting various organs, notably prevalent in women of reproductive age. This review explores the involvement of a disintegrin and metalloproteinases (ADAMs) in SLE pathogenesis. Despite advancements in understanding SLE through genome and transcriptome studies, the role of ADAMs in post-translational regulations remains insufficiently explored. ADAMs, transmembrane proteins with diverse functions, impact cell adhesion, migration, and inflammation by shedding cell surface proteins, growth factors, and receptors...
March 6, 2024: Clinical Immunology: the Official Journal of the Clinical Immunology Society
https://read.qxmd.com/read/38455057/il11-mediated-stromal-cell-activation-may-not-be-the-master-regulator-of-pro-fibrotic-signaling-downstream-of-tgf%C3%AE
#30
JOURNAL ARTICLE
Yunhao Tan, Kenta Mosallanejad, Qingxiu Zhang, Stephen O'Brien, Meghan Clements, Stuart Perper, Sarah Wilson, Sudiksha Chaulagain, Jing Wang, Mary Abdalla, Helen Al-Saidi, Danyal Butt, Anca Clabbers, Kwasi Ofori, Beth Dillon, Bohdan Harvey, John Memmott, Christopher Negron, David Winarta, Catherine Tan, Amlan Biswas, Feng Dong, Vanessa Morales-Tirado, Xiaoqing Lu, Gurminder Singh, Michael White, Shanna Ashley, Heather Knight, Susan Westmoreland, Lucy Phillips, Tracy Carr, Lauren Reinke-Breen, Rajeeva Singh, Jianwen Xu, Kan Wu, Lisa Rinaldi, Brian Stoll, Yupeng David He, Lisa Hazelwood, Jozsef Karman, Andrew McCluskey, William Stine, Ivan Correia, Stephen Gauld, Marc C Levesque, Geertruida Veldman, Cedric Hubeau, Timothy Radstake, Ramkrishna Sadhukhan, Edda Fiebiger
Fibrotic diseases, such as idiopathic pulmonary fibrosis (IPF) and systemic scleroderma (SSc), are commonly associated with high morbidity and mortality, thereby representing a significant unmet medical need. Interleukin 11 (IL11)-mediated cell activation has been identified as a central mechanism for promoting fibrosis downstream of TGFβ. IL11 signaling has recently been reported to promote fibroblast-to-myofibroblast transition, thus leading to various pro-fibrotic phenotypic changes. We confirmed increased mRNA expression of IL11 and IL11Rα in fibrotic diseases by OMICs approaches and in situ hybridization...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38455055/mapping-of-a-hybrid-insulin-peptide-in-the-inflamed-islet-%C3%AE-cells-from-nod-mice
#31
JOURNAL ARTICLE
Janet M Wenzlau, Orion J Peterson, Anthony N Vomund, James E DiLisio, Anita Hohenstein, Kathryn Haskins, Xiaoxiao Wan
There is accumulating evidence that pathogenic T cells in T1D recognize epitopes formed by post-translational modifications of β-cell antigens, including hybrid insulin peptides (HIPs). The ligands for several CD4 T-cell clones derived from the NOD mouse are HIPs composed of a fragment of proinsulin joined to peptides from endogenous β-cell granule proteins. The diabetogenic T-cell clone BDC-6.9 reacts to a fragment of C-peptide fused to a cleavage product of pro-islet amyloid polypeptide (6.9HIP)...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38453577/the-translational-potential-of-studying-bat-immunity
#32
REVIEW
Kaushal Baid, Aaron T Irving, Nolwenn Jouvenet, Arinjay Banerjee
Molecular studies in bats have led to the discovery of antiviral adaptations that may explain how some bat species have evolved enhanced immune tolerance towards viruses. Accumulating data suggest that some bat species have also evolved remarkable features of longevity and low rates of cancer. Furthermore, recent research strongly suggests that discovering immune adaptations in bat models can be translated to develop immune modulators and recognize alternate therapeutic strategies for diseases affecting humans...
February 23, 2024: Trends in Immunology
https://read.qxmd.com/read/38452960/il-33-friend-or-foe-in-transplantation
#33
REVIEW
Ghandi F Hassan, Lucy S Cohen, Jen Alexander-Brett
Several reports have highlighted the dichotomous nature of the IL-33 system in cardiac and lung disease, where this cytokine can exert both protective effects and drive pro-inflammatory responses in a context-specific manner. This State-of-the-Art review focuses on preclinical mechanistic studies of the IL-33 system in development of allograft rejection in heart and lung transplantation. We address the scope of potential cellular sources of IL-33 and pathways for cellular release that may impact the study of this cytokine system in transplant models...
March 5, 2024: Journal of Heart and Lung Transplantation
https://read.qxmd.com/read/38452959/immunological-lectins-in-shrimp-penaeus-vannamei-challenged-with-infectious-myonecrosis-virus-imnv-under-low-salinity-conditions
#34
JOURNAL ARTICLE
Jhonatas Teixeira Viana, Rafael Dos Santos Rocha, Rodrigo Maggioni
Lectins are proteins capable of recognizing and binding to glycan in a specific way. In invertebrates, lectins are a crucial group of Pattern Recognition Proteins (PRRs), activating cellular and humoral responses in the innate immune system. The shrimp Penaeus vannamei is the main crustacean cultivated worldwide, however, the productivity of cultures is strongly affected by diseases, mainly viral ones, such as Infectious Myonecrosis (IMN). Thus, we investigated the participation of five lectins (LvAV, LvCTL4, LvCTL5, LvCTLU, and LvLdlrCTL) in IMNV-challenged shrimp...
March 5, 2024: Fish & Shellfish Immunology
https://read.qxmd.com/read/38452444/application-of-chimeric-antigen-receptor-therapy-beyond-oncology-a-bibliometric-and-visualized-analysis
#35
JOURNAL ARTICLE
Linxin Yang, Jinshen He, Jiahao Liu, Tianjian Xie, Qi Tang
PURPOSE: Chimeric antigen receptor therapy beyond oncology has gained increasing attention. While a substantial number of publications have emerged in recent years, there has been a paucity of conducted bibliometric studies. Our objective is to systematically summarize and visually analyze the literature in the field of chimeric antigen receptors therapy beyond oncology and explore hotspots in this field. METHODS: Web of Science Core Collection was selected as the data source, and the data was retrieved on December 23, 2022, according to the search strategy...
February 6, 2024: Current Research in Translational Medicine
https://read.qxmd.com/read/38451706/deciphering-the-receptor-mediated-signaling-pathways-of-interleukin-19-and-interleukin-20
#36
JOURNAL ARTICLE
Vineetha Shaji, Shobha Dagamajalu, Diya Sanjeev, Mejo George, Saptami Kanekar, Ganesh Prasad, Thottethodi Subrahmanya Keshava Prasad, Rajesh Raju, Rex Devasahayam Arokia Balaya
Interleukin-19 (IL-19) and Interleukin-20 (IL-20) are inflammatory cytokines belonging to the IL-10 family with immunoregulatory properties. Emerging evidence highlights the importance of association of these cytokines with both immunological and inflammatory disorders, including chronic inflammation, cardiac dysfunction, and cancer. IL-19 and IL-20 bind to the heterodimeric receptor complex and induce multiple downstream signaling cascades by activating the signal transducer and activator of transcription 3 (STAT3), Jun N-terminal kinase (JNK), extracellular signal-regulated kinase (ERK), AKT serine/threonine kinase 1 (AKT1), and NFKB inhibitor alpha (NFKBIA), leading to proinflammatory and anti-inflammatory reactions in cancer, inflammation, tumor microenvironment, and infectious diseases...
March 6, 2024: Journal of Interferon & Cytokine Research
https://read.qxmd.com/read/38451413/variation-of-peripheral-blood-based-biomarkers-for-response-of-anti-pd-1-immunotherapy-in-non-small-cell-lung-cancer
#37
JOURNAL ARTICLE
Xiaoming Wang, Dayu Chen, Yuyan Ma, Dongping Mo, Feng Yan
PURPOSE: Immune checkpoint inhibitors (ICIs) for non-small-cell lung cancer (NSCLC) are on the rise, but unfortunately, only a small percentage of patients benefit from them in the long term. Thus, it is crucial to identify biomarkers that can forecast the efficacy of immunotherapy. METHODS: We retrospectively studied 224 patients with NSCLC who underwent anti-PD-1 therapy. The role of biomarkers and clinical characteristics were assessed in a prognostic model. RESULTS: Only 14...
March 7, 2024: Clinical & Translational Oncology
https://read.qxmd.com/read/38445024/presentation-and-progression-of-mpo-anca-interstitial-lung-disease
#38
JOURNAL ARTICLE
Lorenzo Salvati, Boaz Palterer, Elena Lazzeri, Emanuele Vivarelli, Marina Amendola, Marco Allinovi, Leonardo Caroti, Alessio Mazzoni, Laura Lasagni, Giacomo Emmi, Edoardo Cavigli, Marco Del Carria, Linda Di Pietro, Mariangela Scavone, Daniele Cammelli, Federico Lavorini, Sara Tomassetti, Elisabetta Rosi, Paola Parronchi
The association between MPO-ANCA-associated vasculitis (AAV) and interstitial lung disease (ILD) has been well established. Pulmonary fibrosis may coexist with, follow, or even precede the diagnosis of AAV, and its presence adversely affects the prognosis. The optimal approach to investigating ANCA in patients with ILD remains a subject of ongoing debate. Here we aim to describe presentation and progression of MPO-ANCA ILD. We conducted a retrospective evaluation of a cohort of individuals diagnosed with MPO-ANCA ILD, with or without accompanying renal impairment, at the Immunology and Cell Therapy Unit, Careggi University Hospital, Florence, Italy, between June 2016 and June 2022...
June 2024: Journal of translational autoimmunity
https://read.qxmd.com/read/38441967/cd8-t-cells-sustain-antitumor-response-by-mediating-crosstalk-between-adenosine-a2a-receptor-and-glutathione-gpx4
#39
JOURNAL ARTICLE
Siqi Chen, Jie Fan, Ping Xie, Jihae Ahn, Michelle Fernandez, Leah K Billingham, Jason Miska, Jennifer D Wu, Derek A Wainwright, Deyu Fang, Jeffrey A Sosman, Yong Wan, Yi Zhang, Navdeep S Chandel, Bin Zhang
Antitumor responses of CD8+ T cells are tightly regulated by distinct metabolic fitness. High levels of glutathione (GSH) are observed in the majority of tumors contributing to cancer progression and treatment resistance in part by preventing glutathione peroxidase 4 (GPX4) dependent ferroptosis. Here, we show the necessity of the adenosine A2A receptor (A2AR) signaling and the glutathione (GSH)-GPX4 axis in orchestrating metabolic fitness and survival of functionally competent CD8+ T cells. Activated CD8+ T cells treated ex vivo with simultaneous inhibition of A2AR and lipid peroxidation acquire a superior capacity to proliferate and persist in vivo, demonstrating a translatable means to prevent ferroptosis in adoptive cell therapy (ACT)...
March 5, 2024: Journal of Clinical Investigation
https://read.qxmd.com/read/38433763/immunoglobulin-g-genetic-variation-can-confound-assessment-of-antibody-levels-via-altered-binding-to-detection-reagents
#40
JOURNAL ARTICLE
Ruth A Purcell, L Carissa Aurelia, Robyn Esterbauer, Lilith F Allen, Katherine A Bond, Deborah A Williamson, Janine M Trevillyan, Jason A Trubiano, Jennifer J Juno, Adam K Wheatley, Miles P Davenport, Thi Ho Nguyen, Katherine Kedzierska, Stephen J Kent, Kevin John Selva, Amy W Chung
OBJECTIVES: Amino acid variations across more than 30 immunoglobulin (Ig) allotypes may introduce structural changes that influence recognition by anti-Ig detection reagents, consequently confounding interpretation of antibody responses, particularly in genetically diverse cohorts. Here, we assessed a panel of commercial monoclonal anti-IgG1 clones for capacity to universally recognise two dominant IgG1 haplotypes (G1m-1,3 and G1m1,17). METHODS: Four commercial monoclonal anti-human IgG1 clones were assessed via ELISAs and multiplex bead-based assays for their ability to bind G1m-1,3 and G1m1,17 IgG1 variants...
2024: Clinical & Translational Immunology
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