keyword
https://read.qxmd.com/read/38492220/ythdf1-clock-axis-contributes-to-pathogenesis-of-allergic-airway-inflammation-through-llps
#1
JOURNAL ARTICLE
Jing Wang, Yao Zhou, Meng Zhang, Yujiao Wu, Qun Wu, Wen Su, Min Xu, Jinhong Wu, Min Zhang, Jianwei Shuai, Wei Tang, Jiajia Lv, Min Wu, Zhenwei Xia
N6-methyladenosine (m6A) modification has been implicated in many cell processes and diseases. YTHDF1, a translation-facilitating m6A reader, has not been previously shown to be related to allergic airway inflammation. Here, we report that YTHDF1 is highly expressed in allergic airway epithelial cells and asthmatic patients and that it influences proinflammatory responses. CLOCK, a subunit of the circadian clock pathway, is the direct target of YTHDF1. YTHDF1 augments CLOCK translation in an m6A-dependent manner...
March 14, 2024: Cell Reports
https://read.qxmd.com/read/38490536/the-pregnancy-associated-protein-glycodelin-as-a-potential-sex-specific-target-for-resistance-to-immunotherapy-in-non-small-cell-lung-cancer
#2
JOURNAL ARTICLE
Sarah Richtmann, Sebastian Marwitz, Thomas Muley, Hannu Koistinen, Petros Christopoulos, Michael Thomas, Daniel Kazdal, Michael Allgäuer, Hauke Winter, Torsten Goldmann, Michael Meister, Ursula Klingmüller, Marc A Schneider
Lung cancer has been shown to be targetable by novel immunotherapies which reactivate the immune system and enable tumor cell killing. However, treatment failure and resistance to these therapies is common. Consideration of sex as a factor influencing therapy resistance is still rare. We hypothesize that the success of the treatment is impaired by the presence of the immunosuppressive pregnancy-associated glycoprotein glycodelin that is expressed in patients with non-small-cell lung cancer (NSCLC). We demonstrate that the glycan pattern of NSCLC-derived glycodelin detected by a lectin-based enrichment assay highly resembles amniotic fluid-derived glycodelin A, which is known to have immunosuppressive properties...
March 13, 2024: Translational Research: the Journal of Laboratory and Clinical Medicine
https://read.qxmd.com/read/38489677/c3ar1-is-a-regulatory-factor-associated-with-coagulation-cascade-and-inflammation-in-sepsis
#3
JOURNAL ARTICLE
Xuanrong Ren, Qinghui Fu
Sepsis is a leading cause of mortality in intensive care units. Sepsis is associated with activation of the coagulation cascade and inflammation. The aim of this study was to identify coagulation-related genes in sepsis that may provide translational potential therapeutic targets. The datasets GSE28750, GSE95233, and GSE65682 were downloaded from the gene expression omnibus database. Consensus-weighted gene co-expression network analysis (WGCNA) was used to identify sepsis modules. Gene set enrichment analysis was used to identify genes enriched in the coagulation cascade...
March 15, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38489266/pad4-controls-tumor-immunity-via-restraining-the-mhc-class-ii-machinery-in-macrophages
#4
JOURNAL ARTICLE
Michael R Pitter, Ilona Kryczek, Hongjuan Zhang, Nisha Nagarsheth, Houjun Xia, Zhenyu Wu, Yuzi Tian, Karolina Okla, Peng Liao, Weichao Wang, Jiajia Zhou, Gaopeng Li, Heng Lin, Linda Vatan, Sara Grove, Shuang Wei, Yongqing Li, Weiping Zou
Tumor-associated macrophages (TAMs) shape tumor immunity and therapeutic efficacy. However, it is poorly understood whether and how post-translational modifications (PTMs) intrinsically affect the phenotype and function of TAMs. Here, we reveal that peptidylarginine deiminase 4 (PAD4) exhibits the highest expression among common PTM enzymes in TAMs and negatively correlates with the clinical response to immune checkpoint blockade. Genetic and pharmacological inhibition of PAD4 in macrophages prevents tumor progression in tumor-bearing mouse models, accompanied by an increase in macrophage major histocompatibility complex (MHC) class II expression and T cell effector function...
March 13, 2024: Cell Reports
https://read.qxmd.com/read/38489265/translational-genetics-identifies-a-phosphorylation-switch-in-card9-required-for-innate-inflammatory-responses
#5
JOURNAL ARTICLE
Marta Brandt, Zhifang Cao, Chirag Krishna, Jennifer L Reedy, Xiebin Gu, Richard A Dutko, Blayne A Oliver, Betsabeh Khoramian Tusi, Jihye Park, Lauren Richey, Åsa Segerstolpe, Scott Litwiler, Elizabeth A Creasey, Kimberly L Carey, Jatin M Vyas, Daniel B Graham, Ramnik J Xavier
Population genetics continues to identify genetic variants associated with diseases of the immune system and offers a unique opportunity to discover mechanisms of immune regulation. Multiple genetic variants linked to severe fungal infections and autoimmunity are associated with caspase recruitment domain-containing protein 9 (CARD9). We leverage the CARD9 R101C missense variant to uncover a biochemical mechanism of CARD9 activation essential for antifungal responses. We demonstrate that R101C disrupts a critical signaling switch whereby phosphorylation of S104 releases CARD9 from an autoinhibited state to promote inflammatory responses in myeloid cells...
March 13, 2024: Cell Reports
https://read.qxmd.com/read/38488856/early-exposure-to-maternal-stress-and-risk-for-atopic-dermatitis-in-children-a-systematic-review-and-meta-analysis
#6
REVIEW
Yuan Ai, Jichong Huang, Ting Ting Zhu
BACKGROUND: The incidence of atopic dermatitis (AD) in children is increasing. Early exposure to stress factors may be associated with the AD development. This study aimed to summarize studies that reported an association between stress exposure and AD development in later life. METHODS AND FINDINGS: A comprehensive literature search was performed using online databases (PubMed, EMBASE, PsycINFO, and Web of Science) for articles published up to May 1, 2023. Eligible studies were screened and selected based on the inclusion criteria...
March 2024: Clinical and Translational Allergy
https://read.qxmd.com/read/38487541/new-insights-into-the-role-of-immunity-and-inflammation-in-diabetic-kidney-disease-in-the-omics-era
#7
REVIEW
Xinrong Hu, Sixiu Chen, Siyang Ye, Wei Chen, Yi Zhou
Diabetic kidney disease (DKD) is becoming the leading cause of chronic kidney disease, especially in the industrialized world. Despite mounting evidence has demonstrated that immunity and inflammation are highly involved in the pathogenesis and progression of DKD, the underlying mechanisms remain incompletely understood. Substantial molecules, signaling pathways, and cell types participate in DKD inflammation, by integrating into a complex regulatory network. Most of the studies have focused on individual components, without presenting their importance in the global or system-based processes, which largely hinders clinical translation...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38487538/control-of-immune-cell-signaling-by-the-immuno-metabolite-itaconate
#8
REVIEW
Roland Lang, Md Nur A Alam Siddique
Immune cell activation triggers signaling cascades leading to transcriptional reprogramming, but also strongly impacts on the cell's metabolic activity to provide energy and biomolecules for inflammatory and proliferative responses. Macrophages activated by microbial pathogen-associated molecular patterns and cytokines upregulate expression of the enzyme ACOD1 that generates the immune-metabolite itaconate by decarboxylation of the TCA cycle metabolite cis-aconitate. Itaconate has anti-microbial as well as immunomodulatory activities, which makes it attractive as endogenous effector metabolite fighting infection and restraining inflammation...
2024: Frontiers in Immunology
https://read.qxmd.com/read/38486250/clps-mir-103a-2-5p-inhibits-proliferation-and-promotes-cell-apoptosis-in-aml-cells-by-targeting-lilrb3-and-nrf2-ho-1-axis-regulating-cd8%C3%A2-%C3%A2-t-cell-response
#9
JOURNAL ARTICLE
Qingyan Cen, Jianyu Chen, Jiaxin Guo, Mu Chen, Hao Wang, Suwan Wu, Honghao Zhang, Xiaoling Xie, Yuhua Li
BACKGROUND: LILRB3, a member of the leukocyte immunoglobulin-like receptor B (LILRB) family, has immunosuppressive functions and directly regulates cancer development, which indicates that LILRB3 is an attractive target for cancer diagnosis and therapy. Novel therapeutic treatments for acute myeloid leukemia (AML) are urgent and important, and RNA therapeutics including microRNAs (miRNAs) could be an effective option. Here, we investigate the role of dysregulated miRNA targeting LILRB3 in the AML microenvironment...
March 14, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38485910/a-quality-of-life-study-in-patients-with-anaphylaxis-to-hymenoptera-venom-in-iran
#10
JOURNAL ARTICLE
Mohammad Hasan Bemaniyan, Maryam Heidari, Marzieh Tavakol, Mohammad Nabavi, Fatemeh Ramezani Kashal, Maryam Gholami, Bita Bemaniyan
Little is known about the quality of life of patients with anaphylaxis to Hymenoptera venom. The Vespid Allergy Quality of Life Questionnaire (VQLQ) is commonly used to assess the psychological burden of this condition. This study aimed to evaluate the validity and reliability of the Persian version of VQLQ. In this cross-sectional study, VQLQ was translated into Persian according to expert recommendations.  The final translated version of VQLQ was then administered to 115 patients with Hymenoptera venom allergy at an asthma and allergy clinic in Iran...
February 11, 2024: Iranian Journal of Allergy, Asthma, and Immunology
https://read.qxmd.com/read/38482441/a-comprehensive-analysis-of-the-prognostic-and-immunological-role-of-ank3-in-pan-cancer
#11
JOURNAL ARTICLE
Yunfei Tan, Wei Meng, Zhaosheng Jiang, Ningning Li, Tong Zhang, Jiayi Zhang, Limin Ma, Yangbo Guan
BACKGROUND: Cancer is a common cause of death around the world. Immunotherapy plays a significant role in cancer treatment but still has limitations. The ankyrin-3 ( ANK3 ) gene has been shown to have a variety of biological roles and has also been shown to be closely linked to individual cancers. METHODS: We systematically investigated the role of ANK3 in pan-cancer, particularly in relation to immunity. We collected data from a number of databases, including the The University of ALabama at Birmingham CANcer data analysis Portal (UALCAN), tumor-immune system interactions (TISIDB), cBioPortal, Tumor Immune Estimation Resource (TIMER), Search Tool for the Retrieval of Interacting Genes/Proteins (STRING), BioGRID, and SangerBox databases...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38482423/-nf2-is-a-candidate-diagnosis-prognostic-and-immunotherapeutic-biomarker-a-systematic-pan-cancer-analysis
#12
JOURNAL ARTICLE
Honglu Zhang, Jiyong Liu
BACKGROUND: Neurofibromin 2 ( NF2 ) regulates diverse cellular events such as transcription, translation, ubiquitination, and micro-RNA biosynthesis. Previous evidence revealed that aberrant expression of NF2 contributes to tumorigenesis in mesothelioma, meningioma, and breast cancer. However, there is no comprehensive pan-cancer analysis to explore NF2 's function in cancer diagnosis, prognosis, and immunological prediction. METHODS: By extensive use of data profiles from The Cancer Genome Atlas (TCGA), Genotype-Tissue Expression (GTEx) project, Cancer Cell Line Encyclopedia (CCLE), CIBERSORT, Human Protein Atlas (HPA), and cBioPortal, we employed various bioinformatics methods to explore the role of NF2 in pan-cancer, including analyzing the association between NF2 and tumor diagnosis, prognosis, immune cell infiltration, tumor mutational burden (TMB), and microsatellite instability (MSI)...
February 29, 2024: Translational Cancer Research
https://read.qxmd.com/read/38481614/prediction-of-intravenous-immunoglobulin-retreatment-in%C3%A2-children-with-kawasaki-disease-using-models-combining%C3%A2-lymphocyte-subset-and-cytokine-profile-in%C3%A2-an%C3%A2-east-asian-cohort
#13
JOURNAL ARTICLE
Chun Zhang, Sun Chen, Yan Bian, Xiaohua Qian, Yurui Liu, Liqing Zhao, Jia Shen, Jiani Song, Peng Zhang, Lun Chen, Limin Jiang
OBJECTIVES: For children with Kawasaki disease (KD) at high risk of developing coronary artery lesions and requiring retreatment with intravenous immunoglobulin (IVIG), the availability of accurate prediction models remains limited because of inconsistent variables and unsatisfactory prediction results. We aimed to construct models to predict patient's probability of IVIG retreatment combining children's individual inflammatory characteristics. METHODS: Clinical manifestations and laboratory examinations of 266 children with KD were retrospectively analysed to build a development cohort data set (DC) and a validation cohort data set (VC)...
2024: Clinical & Translational Immunology
https://read.qxmd.com/read/38477873/xiaoyu-hu-let-the-data-guide-you
#14
JOURNAL ARTICLE
Lucie Van Emmenis
Xiaoyu Hu is a professor and director of the Institute for Immunology at Tsinghua University. Her lab is interested in understanding the molecular mechanisms underlying the transcriptional, translational, and metabolic mechanisms of the key cell types involved in host defense and inflammatory responses: macrophages and intestinal epithelial cells (IECs). We recently spoke with Xiaoyu about her current work, the benefits of a multidisciplinary team, and how being part of journal editorial boards brings her intellectual stimulation and inspiration for her own lab...
April 1, 2024: Journal of Experimental Medicine
https://read.qxmd.com/read/38477824/translational-frontiers-and-clinical-opportunities-of-immunologically-fitted-radiotherapy
#15
JOURNAL ARTICLE
Daphné Morel, Charlotte Robert, Nikos Paragios, Vincent Grégoire, Eric Deutsch
Ionising radiations can have a wide range of impacts on tumour-immune interactions, which are being studied with the greatest interest and at an accelerating pace by the medical community. Despite its undeniable immunostimulatory potential, it clearly appears that radiotherapy as it is prescribed and delivered nowadays often alters the host's immunity towards a suboptimal state. This may impair the full recovery of a sustained and efficient anti-tumour immunosurveillance post-treatment. An emerging concept is arising from this awareness and consists in re-considering the way of designing radiation treatment plannings, notably by taking into account the individualised risks of deleterious radio-induced immune alteration that can be deciphered from the planned beam trajectory through lymphocyte-rich organs...
March 13, 2024: Clinical Cancer Research
https://read.qxmd.com/read/38474389/unraveling-atopic-dermatitis-insights-into-pathophysiology-therapeutic-advances-and-future-perspectives
#16
REVIEW
Ashutosh Pareek, Lipika Kumari, Aaushi Pareek, Simran Chaudhary, Yashumati Ratan, Pracheta Janmeda, Sanam Chuturgoon, Anil Chuturgoon
Atopic dermatitis (AD) is an inflammatory skin condition that frequently develops before the onset of allergic rhinitis or asthma. More than 10% of children are affected by this serious skin condition, which is painful for the sufferers. Recent research has connected the environment, genetics, the skin barrier, drugs, psychological factors, and the immune system to the onset and severity of AD. The causes and consequences of AD and its cellular and molecular origins are reviewed in this paper. The exploration of interleukins and their influence on the immunological pathway in AD has been facilitated by using relevant biomarkers in clinical trials...
February 28, 2024: Cells
https://read.qxmd.com/read/38473379/intratumoral-delivery-of-interleukin-9-via-oncolytic-vaccinia-virus-elicits-potent-antitumor-effects-in-tumor-models
#17
JOURNAL ARTICLE
Junjie Ye, Lingjuan Chen, Julia Waltermire, Jinshun Zhao, Jinghua Ren, Zongsheng Guo, David L Bartlett, Zuqiang Liu
The success of cancer immunotherapy is largely associated with immunologically hot tumors. Approaches that promote the infiltration of immune cells into tumor beds are urgently needed to transform cold tumors into hot tumors. Oncolytic viruses can transform the tumor microenvironment (TME), resulting in immunologically hot tumors. Cytokines are good candidates for arming oncolytic viruses to enhance their function in this transformation. Here, we used the oncolytic vaccinia virus (oVV) to deliver interleukin-9 (IL-9) into the tumor bed and explored its antitumor effects in colon and lung tumor models...
February 29, 2024: Cancers
https://read.qxmd.com/read/38472405/glymphatic-lymphatic-coupling-assessment-of-the-evidence-from-magnetic-resonance-imaging-of-humans
#18
REVIEW
Geir Ringstad, Per Kristian Eide
The discoveries that cerebrospinal fluid participates in metabolic perivascular exchange with the brain and further drains solutes to meningeal lymphatic vessels have sparked a tremendous interest in translating these seminal findings from animals to humans. A potential two-way coupling between the brain extra-vascular compartment and the peripheral immune system has implications that exceed those concerning neurodegenerative diseases, but also imply that the central nervous system has pushed its immunological borders toward the periphery, where cross-talk mediated by cerebrospinal fluid may play a role in a range of neoplastic and immunological diseases...
March 13, 2024: Cellular and Molecular Life Sciences: CMLS
https://read.qxmd.com/read/38471362/cd28-null-t-cells-in-aging-and-diseases-from-biology-to-assessment-and-intervention
#19
REVIEW
Yuqi Guan, Ming Cao, Xiaofen Wu, Jinhua Yan, Yi Hao, Cuntai Zhang
CD28null T cells, an atypical subset characterized by the loss of CD28 costimulatory molecule expression, exhibit functional variants and progressively expand with age. Moreover, T cells with these phenotypes are found in both typical and atypical humoral immune responses. Consequently, they accumulate during infectious diseases, autoimmune disorders, cardiovascular conditions, and neurodegenerative ailments. To provide an in-depth review of the current knowledge regarding CD28null T cells, we specifically focus on their phenotypic and functional characteristics as well as their physiological roles in aging and diseases...
March 11, 2024: International Immunopharmacology
https://read.qxmd.com/read/38470480/rare-neutralizing-ifn-%C3%AE-autoantibodies-in-hla-drb1-15-02-or-16-02-individuals-confer-susceptibility-to-mycobacterial-infections
#20
JOURNAL ARTICLE
Jessica N Peel, Rui Yang, Tom Le Voyer, Adrian Gervais, Jérémie Rosain, Paul Bastard, Anish Behere, Axel Cederholm, Aaron Bodansky, Yoann Seeleuthner, Clément Conil, Jing-Ya Ding, Wei-Te Lei, Lucy Bizien, Camille Soudee, Mélanie Migaud, Masato Ogishi, Ahmad Yatim, Danyel Lee, Jonathan Bohlen, Thomas Perpoint, Laura Perez, Fernando Messina, Roxana Genet, Ludovic Karkowski, Mathieu Blot, Emmanuel Lafont, Laurie Toullec, Claire Goulvestre, Souad Mehlal-Sedkaoui, Jérôme Sallette, Fernando Martin, Anne Puel, Emmanuelle Jouanguy, Mark S Anderson, Nils Landegren, Pierre Tiberghien, Laurent Abel, Stéphanie Boisson-Dupuis, Jacinta Bustamante, Cheng-Lung Ku, Jean-Laurent Casanova
BACKGROUND: Weakly virulent environmental mycobacteria (EM) can cause severe disease in HLA-DRB1*15:02 or 16:02 adult individuals harboring neutralizing anti-IFN-γ autoantibodies (nAIGAs). The overall prevalence of nAIGA in a general population are unknown as is the the penetrance of nAIGA in HLA-DRB1*15:02 or 16:02 individuals, and the proportion of patients with unexplained, adult-onset EM infections carrying nAIGAs. METHODS: This study analyzed the detection and neutralization of anti-IFN-γ autoantibodies (auto-Abs) from 8,430 healthy individuals of the general population, 257 HLA-DRB1*15:02 or 16:02 carriers, 1,063 patients with autoimmune disease, and 497 patients with unexplained severe disease due to EM...
March 12, 2024: Journal of Clinical Investigation
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