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Impingement test

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https://www.readbyqxmd.com/read/28097008/preclinical-findings-predicting-efficacy-and-side-effect-profile-of-ly2940094-an-antagonist-of-nociceptin-receptors
#1
Jeffrey M Witkin, Linda M Rorick-Kehn, Mark J Benvenga, Benjamin L Adams, Scott D Gleason, Karen M Knitowski, Xia Li, Steven Chaney, Julie F Falcone, Janice W Smith, Julie Foss, Kirsti Lloyd, John T Catlow, David L McKinzie, Kjell A Svensson, Vanessa N Barth, Miguel A Toledo, Nuria Diaz, Celia Lafuente, Alma Jiménez, Alfonso Benito, Conception Pedregal, Maria A Martínez-Grau, Anke Post, Michael A Ansonoff, John E Pintar, Michael A Statnick
Nociceptin/Orphanin FQ (N/OFQ) is a 17 amino acid peptide whose receptor is designated ORL1 or nociceptin receptor (NOP). We utilized a potent, selective, and orally bioavailable antagonist with documented engagement with NOP receptors in vivo to assess antidepressant- and anxiolytic-related pharmacological effects of NOP receptor blockade along with measures of cognitive and motor impingement. LY2940094 ([2-[4-[(2-chloro-4,4-difluoro-spiro[5H-thieno[2,3-c]pyran-7,4'-piperidine]-1'-yl)methyl]-3-methyl-pyrazol-1-yl]-3-pyridyl]methanol) displayed antidepressant-like behavioral effects in the forced-swim test in mice, an effect absent in NOP (-/-) mice...
December 2016: Pharmacology Research & Perspectives
https://www.readbyqxmd.com/read/28095505/can-early-intervention-improve-maternal-well-being-evidence-from-a-randomized-controlled-trial
#2
Orla Doyle, Liam Delaney, Christine O'Farrelly, Nick Fitzpatrick, Michael Daly
OBJECTIVE: This study estimates the effect of a targeted early childhood intervention program on global and experienced measures of maternal well-being utilizing a randomized controlled trial design. The primary aim of the intervention is to improve children's school readiness skills by working directly with parents to improve their knowledge of child development and parenting behavior. One potential externality of the program is well-being benefits for parents given its direct focus on improving parental coping, self-efficacy, and problem solving skills, as well as generating an indirect effect on parental well-being by targeting child developmental problems...
2017: PloS One
https://www.readbyqxmd.com/read/28095214/stretching-exercises-for-shoulder-impingement-syndrome-effects-of-6-week-program-on-shoulder-tightness-pain-and-disability-status
#3
Elif Turgut, Irem Duzgun, Gul Baltaci
CONTEXT: Increasing soft tissue flexibility and joint mobility is one of the important aims of the shoulder impingement syndrome (SIS). OBJECTIVE: The aim of this study was to investigate the effects of stretching program on posterior capsule tightness, pectoralis minor tightness, pain severity and disability status in SIS. DESIGN: Single-group pre-test post-test design. SETTING: University outpatient clinic. PARTICIPANTS: Eighteen participants diagnosed with subacromial impingement syndrome (34...
January 17, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/28089193/brake-reaction-time-after-hip-arthroscopy-for-femoroacetabular-impingement-and-labral-tear
#4
Angelina M Vera, Naseem Beauchman, Patrick C McCulloch, Brayden J Gerrie, Domenica A Delgado, Joshua D Harris
PURPOSE: To determine if a difference exists in brake reaction time (BRT) before and after hip arthroscopy for femoroacetabular impingement (FAI) and labral tear compared with age- and gender-matched controls. METHODS: Consecutive adult subjects undergoing primary hip arthroscopy were eligible for this prospective investigation. Individuals with symptomatic FAI and labral tear that underwent hip arthroscopy with minimum 8 weeks follow-up were included. BRT was measured using the RT-2S reaction time tester a maximum of 6 weeks preoperatively and every 2 weeks postoperatively for 8 weeks...
January 11, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/28075182/dispersing-the-mists-an-experimental-history-of-medicine-study-into-the-quality-of-volatile-inhalations
#5
Barry Murnane, Cathal T Gallagher, Noel Snell, Mark Sanders, Ramin Moshksar, Darragh Murnane
BACKGROUND: Dr. Nelson's Improved Inhaler was first marketed with an advertisement in The Lancet in 1865. Revolutionary at the time for its ease of use and patient-friendliness, the inhaler is still in use for self-treatment by many all over the world. On the occasion of its 150th anniversary, this study reports an experimental historical medicine approach to identify evidence for the quality of vapor inhalers. METHODS: Through accessing reviews of the device's use by the contemporary medical establishment, it was established that Dr...
January 11, 2017: Journal of Aerosol Medicine and Pulmonary Drug Delivery
https://www.readbyqxmd.com/read/28069239/analysis-of-the-effect-of-impact-of-near-wall-acoustic-bubble-collapse-micro-jet-on-al-1060
#6
Linzheng Ye, Xijing Zhu
The bubble collapse near a wall will generate strong micro-jet in a liquid environment under ultrasonic field. To explore the effect of the impact of near-wall acoustic bubble collapse micro-jet on an aluminum 1060 sheet, the cavitation threshold formula and micro-jet velocity formula were first proposed. Then the Johnson-Cook rate correlation material constitutive model was considered, and a three-dimensional fluid-solid coupling model of micro-jet impact on a wall was established and analyzed. Finally, to validate the model, ultrasonic cavitation test and inversion analysis based on the theory of spherical indentation test were conducted...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28066749/comparative-analysis-of-kinesiotherapy-rehabilitation-after-hip-arthroscopy-quantified-by-harris-and-vail-hip-scores-a-retrospective-study
#7
Melissa Saavedra, Ricardo Moraga, Patricia Diaz, Daniel Camacho, Rodrigo Mardones
BACKGROUND: It has been proven that femoroacetabular impingement cases improve following arthroscopic surgery. However, rehabilitation has a major role in the patient's recovery. The protocol used by our institution consists of an evidence-based guideline for the different phases of rehabilitation. OBJECTIVE: Describe and determine the effectiveness of our institution's kinesiotherapy rehabilitation program during 2011-2016, comparing Harris and Vail Hip Scores scales (HHS and VHS, respectively) at the beginning of each treatment phase...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28066746/arthroscopic-treatment-of-femoroacetabular-impingement-in-patients-older-than-60-years
#8
Rodrigo Mardones, Alessio Giai Via, Alvaro Rivera, Alexander Tomic, Marcelo Somarriva, Mauricio Wainer, Daniel Camacho
BACKGROUND: The indications of hip arthroscopy increased over the past decade. Although mostly recommended for treatment of femoroacetabular impingement (FAI) in young patients, well-selected older patients (> 60 years old) may benefit from this surgery. However, the role of hip arthroscopy for the management of older patients is controversial. The aim of the study is to evaluate the clinical outcomes of a series of patients aged 60 years and older who underwent hip arthroscopy for FAI at mid-term follow-up...
July 2016: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/28060533/morphological-distribution-of-the-anterior-inferior-iliac-spine-in-patients-with-and-without-hip-impingement
#9
George C Balazs, Benjamin C Williams, Christopher M Knaus, Daniel I Brooks, Jonathan F Dickens, Michael P McCabe, Terrence D Anderson
BACKGROUND: Subspinous impingement of the anterior inferior iliac spine (AIIS) on the femoral head-neck junction is increasingly recognized as a source of hip impingement. A classification system of AIIS morphology has previously been proposed that correlates with reduced hip motion and may predispose patients to subspinous hip impingement. PURPOSE: To examine the morphological distribution of AIIS types in patients with and without diagnosed hip impingement and correlate AIIS morphology to intraoperative findings at the time of surgery...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28047937/tu-fg-brb-12-real-time-visualization-of-discrete-spot-scanning-proton-therapy-beam-for-quality-assurance
#10
Y Matsuzaki, C Jenkins, Y Yang, T Yoshimura, Y Fujii, K Umegaki, L Xing
PURPOSE: With the growing adoption of proton beam therapy there is an increasing need for effective and user-friendly tools for performing quality assurance (QA) measurements. The speed and versatility of spot-scanning proton beam (PB) therapy systems present unique challenges for traditional QA tools. To address these challenges a proof-of-concept system was developed to visualize, in real-time, the delivery of individual spots from a spot-scanning PB in order to perform QA measurements...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047889/su-f-t-408-on-the-determination-of-equivalent-squares-for-rectangular-small-mv-photon-fields
#11
O A Sauer, S Wegener, F Exner
PURPOSE: It is common practice to tabulate dosimetric data like output factors, scatter factors and detector signal correction factors for a set of square fields. In order to get the data for an arbitrary field, it is mapped to an equivalent square, having the same scatter as the field of interest. For rectangular fields both, tabulated data and empiric formula exist. We tested the applicability of such rules for very small fields. METHODS: Using the Monte-Carlo method (EGSnrc-doseRZ), the dose to a point in 10cm depth in water was calculated for cylindrical impinging fluence distributions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046252/su-g-jep1-13-innovative-tracking-detector-for-dose-monitoring-in-hadron-therapy-realization-and-monte-carlo-simulations
#12
A Rucinski, G Battistoni, F Collamati, F Collini, E De Lucia, R Faccini, P Frallicciardi, C Mancini-Terracciano, M Marafini, S Muraro, R Paramatti, V Patera, L Piersanti, D Pinci, A Russomando, A Sarti, A Sciubba, E Solfaroli Camillocci, M Toppi, G Traini, C Voena, A Rucinski
PURPOSE: Development of strategies to monitor range uncertainties is necessary to improve treatment planning in Charged Particle Therapy (CPT) and fully exploit the advantages of ion beams. Our group developed (within the framework of the INSIDE project funded by the Italian research ministry) and is currently building a compact detector Dose Profiler (DP) able to backtrack charged secondary particles produced in the patient during the irradiation. Furthermore we are studying monitoring strategy exploiting charged secondary emission profiles to control the range of the ion beam...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28043311/acromion-types-and-role-of-corticosteroid-with-shoulder-impingement-syndrome
#13
Muhammad Akram, Syed Faraz Ul Hassan Shah Gillani, Faheem Mubashir Farooqi, Syed Muhammad Awais
OBJECTIVE: To determine the association between shoulder impingement and morphological characteristics of acromion and the role of sub-acromial injection of methylprednisolone in the short-term treatment for relieving pain and improve functional disability of these patients. STUDY DESIGN: A descriptive study. PLACE AND DURATION OF STUDY: Department of Orthopedic Surgery and Traumatology Unit-I (DOST-I), Mayo Hospital, Lahore, between November 2013 to June 2014...
December 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28040080/is-it-safe-to-assist-proximal-humeral-nailing-to-residents-an-analysis-of-1134-cases
#14
Burak Altintas, Roland Biber, Hermann J Bail
INTRODUCTION: Intramedullary nailing is a common procedure for the treatment of proximal humeral fractures. In practical resident training this standardized operation plays an important role in the introduction to osteosynthesis. Our aim was to investigate whether assisting this operation to residents influences the surgical complication rate both in-house and on re-admission. METHODS: All 1134 patients who received a proximal humeral Targon PH nail (Aesculap) for proximal humeral fractures were included between 2000 and 2013...
December 2016: Injury
https://www.readbyqxmd.com/read/28032029/evaluation-and-treatment-of-internal-impingement-of-the-shoulder-in-overhead-athletes
#15
REVIEW
Keith T Corpus, Christopher L Camp, David M Dines, David W Altchek, Joshua S Dines
One of the most common pathologic processes seen in overhead throwing athletes is posterior shoulder pain resulting from internal impingement. "Internal impingement" is a term used to describe a constellation of symptoms which result from the greater tuberosity of the humerus and the articular surface of the rotator cuff abutting the posterosuperior glenoid when the shoulder is in an abducted and externally rotated position. The pathophysiology in symptomatic internal impingement is multifactorial, involving physiologic shoulder remodeling, posterior capsular contracture, and scapular dyskinesis...
December 18, 2016: World Journal of Orthopedics
https://www.readbyqxmd.com/read/28006109/joint-loading-in-the-sagittal-plane-during-gait-is-associated-with-hip-joint-abnormalities-in-patients-with-femoroacetabular-impingement
#16
Michael A Samaan, Benedikt J Schwaiger, Matthew C Gallo, Kiyoshi Sada, Thomas M Link, Alan L Zhang, Sharmila Majumdar, Richard B Souza
BACKGROUND: Femoroacetabular impingement (FAI) is a morphological abnormality of the hip joint that results in functional impairments during various activities of daily living (ADL) such as walking. Purpose/Hypothesis: The purpose of this study was to determine if lower extremity joint loading differed between patients with FAI and controls and to determine whether these altered biomechanical parameters were associated with intra-articular abnormalities. It was hypothesized that patients with FAI would exhibit altered lower extremity joint loading during walking when compared with healthy controls and that these altered joint loading patterns would be associated with intra-articular abnormalities...
December 1, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28004173/no-difference-in-prevalence-of-radiographic-subspinal-impingement-of-the-hip-between-symptomatic-and-asymptomatic-subjects
#17
Jun-Il Yoo, Yong-Chan Ha, Han-Jun Lee, Jung-Yeop Lee, Young-Kyun Lee, Kyung-Hoi Koo
PURPOSE: The study determined the prevalence of subspinal impingement (SSI) in symptomatic and asymptomatic individuals, morphologic characteristics in symptomatic patients, and risk factors for SSI. METHODS: The study cohort consisted of 427 patients (427 hips; median age 33.4 years; range 19-50 years) with mechanical symptoms who underwent multi-detector computed tomography arthrography (symptomatic patients) and 259 control (asymptomatic) patients who underwent abdominopelvic three-dimensional CT because of a ureter stone or minor trauma...
December 21, 2016: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/27999721/improvements-in-knee-extension-strength-are-associated-with-improvements-in-self-reported-hip-function-following-arthroscopy-for-femoroacetabular-impingement-syndrome
#18
Chelseana C Davis, Thomas J Ellis, Ajit K Amesur, Timothy E Hewett, Stephanie Di Stasi
BACKGROUND: Recovery of strength is critical for return to sport, and is a known predictor of functional outcomes in post-surgical orthopedic populations. Muscle weakness is a known impairment in patients with femoroacetabular impingement syndrome (FAIS) but whether improvements in muscle strength after arthroscopy are associated with improved hip function is unknown. HYPOTHESIS/PURPOSE: To examine the relationships between changes in hip and thigh muscle strength and self-reported function in athletes undergoing arthroscopy for FAIS...
December 2016: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/27998057/spatial-models-of-sewer-pipe-leakage-predict-the-occurrence-of-wastewater-indicators-in-shallow-urban-groundwater
#19
Patrick R Roehrdanz, Marina Feraud, Do Gyun Lee, Jay C Means, Shane A Snyder, Patricia A Holden
Twentieth century municipal wastewater infrastructure greatly improved U.S. urban public health and water quality. However, sewer pipes deteriorate and their accumulated structural defects may release untreated wastewater to the environment via acute breaks or insidious exfiltration. Exfiltrated wastewater constitutes a loss of potentially reusable water and delivers a complex and variable mix of contaminants to urban shallow groundwater. Yet, predicting where deteriorated sewers impinge on shallow groundwater has been challenging...
December 20, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27981665/hip-mri-prevalence-of-articular-cartilage-defects-and-labral-tears-in-asymptomatic-volunteers-a-comparison-with-a-matched-population-of-patients-with-femoroacetabular-impingement
#20
Florian Tresch, Tobias J Dietrich, Christian W A Pfirrmann, Reto Sutter
PURPOSE: To prospectively compare defects of the articular cartilage and labrum in asymptomatic volunteers and in patients with femoroacetabular impingement (FAI) matched for age and gender. MATERIALS AND METHODS: This cross-sectional study was institutional review board approved. A total of 63 asymptomatic volunteers and 63 patients with symptomatic FAI between 20 and 50 years underwent 1.5 Tesla MRI (coronal T1-weighted, coronal intermediate-weighted fat saturated, transverse oblique true fast imaging with steady-state precession [FISP], sagittal dual echo steady state [DESS] sequence)...
December 16, 2016: Journal of Magnetic Resonance Imaging: JMRI
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