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Pre operative risk stratification

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https://www.readbyqxmd.com/read/29327147/post-operative-catheterization-interventions-at-the-site-of-surgery-an-application-of-the-crisp-scoring-system
#1
Katie Mowers, Toby Rockefeller, David Balzer, Ramzi Nicolas, Shabana Shahanavaz
Catheter-based interventions in the early post-operative period are performed with caution due to concerns for increased procedural risk, particularly across fresh suture lines. The recently published CRISP scoring system provides prospective risk stratification based on pre-procedural criterion. In an effort to refine the assessment of risk in patients undergoing post-operative catheter-based interventions, the predicted risk of an adverse event based on CRISP scores was compared to actual adverse event rates...
January 12, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29312648/predicting-clinically-significant-prostate-cancer-based-on-pre-operative-patient-profile-and-serum-biomarkers
#2
Izak Faiena, Sinae Kim, Nicholas Farber, Young Suk Kwon, Brian Shinder, Neal Patel, Amirali H Salmasi, Thomas Jang, Eric A Singer, Wun-Jae Kim, Isaac Y Kim
Previous studies have reported association of multiple preoperative factors predicting clinically significant prostate cancer with varying results. We assessed the predictive model using a combination of hormone profile, serum biomarkers, and patient characteristics in order to improve the accuracy of risk stratification of patients with prostate cancer. Data on 224 patients from our prostatectomy database were queried. Demographic characteristics, including age, body mass index (BMI), clinical stage, clinical Gleason score (GS) as well as serum biomarkers, such as prostate-specific antigen (PSA), parathyroid hormone (PTH), calcium (Ca), prostate acid phosphatase (PAP), testosterone, and chromogranin A (CgA), were used to build a predictive model of clinically significant prostate cancer using logistic regression methods...
December 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29287736/prospective-evaluation-of-the-international-study-group-for-liver-surgery-definition-of-post-hepatectomy-liver-failure-after-liver-resection-an-international-multicentre-study
#3
Asma Sultana, Mark Brooke-Smith, Shahid Ullah, Joan Figueras, Myrddin Rees, Jean-Nicolas Vauthey, Claudius Conrad, Thomas J Hugh, O James Garden, Sheung T Fan, Michael Crawford, Masatoshi Makuuchi, Yukihiro Yokoyama, Markus Büchler, Robert Padbury
BACKGROUND: The International Study Group for Liver Surgery (ISGLS) definition of post hepatectomy liver failure (PHLF) was developed to be consistent, widely applicable, and to include severity stratification. This international multicentre collaborative study aimed to prospectively validate the ISGLS definition of PHLF. METHODS: 11 HPB centres from 7 countries developed a standardised reporting form. Prospectively acquired anonymised data on liver resections performed between 01 July 2010 and 30 June 2011 was collected...
December 26, 2017: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
https://www.readbyqxmd.com/read/29249782/-risk-factors-for-post-operative-respiratory-failure-and-respiratory-tract-infections-following-cardiovascular-surgery
#4
Yui Tabuchi, Yosuke Morimoto, Yudai Yano, Yuichi Tawara, Shuntaro Sato, Kazuyoshi Tanigawa, Kiyoyuki Eishi, Ryo Kozu
INTRODUCTION: Respiratory failure and respiratory tract infections are frequently observed as post-operative pulmonary complications, and significantly contribute to morbidity and mortality. However, the risk factors of post-operative respiratory failure and respiratory tract infections are controversial, and how these factors affect on incidence of complications is still unclear. OBJECTIVE: To identify risk factors of post-operative respiratory failure and respiratory tract infections, and evaluate its impact on incidences after cardiovascular surgery...
December 2017: Kyobu Geka. the Japanese Journal of Thoracic Surgery
https://www.readbyqxmd.com/read/29219922/multimodal-prehabilitation-programs-as-a-bundle-of-care-in-gastrointestinal-cancer-surgery-a-systematic-review
#5
REVIEW
Vladimir Bolshinsky, Michael H-G Li, Hilmy Ismail, Kate Burbury, Bernhard Riedel, Alexander Heriot
BACKGROUND: Prehabilitation reflects a proactive process of preoperative optimization undertaken between cancer diagnosis and definitive surgical treatment, with the intent of improving physiological capacity to withstand the major insult of surgery. Prehabilitation before GI cancer surgery is currently not widely adopted, and most research has focused on unimodal interventions such as exercise therapy, nutritional supplementation, and hematinic optimization. A review of the existing literature was undertaken to investigate the impact of multimodal prehabilitation programs as a "bundle of care...
January 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29217354/prostate-magnetic-resonance-imaging-provides-limited-incremental-value-over-the-memorial-sloan-kettering-cancer-center-pre-radical-prostatectomy-nomogram
#6
John K Weaver, Eric H Kim, Joel M Vetter, Anup Shetty, Robert L Grubb, Seth A Strope, Gerald L Andriole
OBJECTIVES: To examine the incremental value of prostate MRI when used in combination with the currently available preoperative risk stratification tool the Memorial Sloan Kettering Cancer Center Pre-Radical Prostatectomy Nomogram (MSKCC). METHODS: We reviewed our institutional database of prostate MRI performed prior to radical prostatectomy between December 2014 and March 2016 (n=236). We generated a logistic regression model based on observed final pathology results and the MSKCC nomogram predictions for organ confined disease, extracapsular extension (ECE), seminal vesicle invasion (SVI), and lymph node (LN) involvement ('MSKCC Only')...
December 4, 2017: Urology
https://www.readbyqxmd.com/read/29205868/ficoll-hypaque-separation-vs-whole-blood-lysis-comparison-of-efficiency-and-impact-on-minimal-residual-disease-analysis
#7
E Genuardi, D Barbero, I Dogliotti, B Mantoan, D Drandi, M Gambella, G M Zaccaria, L Monitillo, I Della Starza, M Cavalli, L A De Novi, E Ciabatti, S Grassi, A Gazzola, C Mannu, I Del Giudice, S Galimberti, C Agostinelli, P P Piccaluga, M Ladetto, S Ferrero
INTRODUCTION: The high-throughput era remarkably changed molecular laboratory practice. Actually, the increasing number of processed samples requires to reduce the risk of operator biases, by automating or simplifying as much as possible both the analytical and the pre-analytical phases. Minimal residual disease (MRD) studies in hematology often require a simultaneous processing of many bone marrow and peripheral blood samples from patients enrolled in prospective, multicenter, clinical trials, monitored at several planned time points...
December 4, 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/29158067/psoas-muscle-area-as-a-prognostic-factor-for-survival-in-patients-with-an-asymptomatic-infrarenal-abdominal-aortic-aneurysm-a-retrospective-cohort-study
#8
Reza Indrakusuma, Jendé L Zijlmans, Hamid Jalalzadeh, R Nils Planken, Ron Balm, Mark J W Koelemay
OBJECTIVES: Loss of muscle mass has been associated with poor survival in several surgical patient populations, including those with an abdominal aortic aneurysm (AAA). We wanted to replicate these findings and assesse the association between psoas muscle area (PMA) and survival in patients with an asymptomatic AAA. METHODS: Patients with an asymptomatic infrarenal AAA who underwent computed tomography (CT) scanning between January 1, 2007, and December 31, 2013, were included in this single-centre retrospective cohort study...
November 17, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/29155339/body-mass-index-predicts-risk-of-complications-in-lumbar-spine-surgery-based-on-surgical-invasiveness
#9
Olivia J Bono, Gregory W Poorman, Norah Foster, Cyrus M Jalai, Samantha R Horn, Jonathan Oren, Alexandra Soroceanu, Subaraman Ramachandran, Taylor E Purvis, Deeptee Jain, Shaleen Vira, Bassel G Diebo, Breton Line, Daniel M Sciubba, Themistocles S Protopsaltis, Aaron J Buckland, Thomas J Errico, Virginie Lafage, Shay Bess, Peter G Passias
BACKGROUND CONTEXT: Obesity as a comorbidity in spine pathology may increase the risk of complications following surgical treatment. The BMI threshold at which obesity becomes clinically relevant, and the exact nature of that effect, remains poorly understood. PURPOSE: Identify the body mass index (BMI) that independently predicts risk of postoperative complications following lumbar spine surgery. STUDY DESIGN/SETTING: Retrospective review of the National Surgery Quality Improvement Program (NSQIP) years 2011-2013...
November 16, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29153562/noncontrast-myocardial-t1-mapping-by-cardiac-magnetic-resonance-predicts-outcome-in-patients-with-aortic-stenosis
#10
Heesun Lee, Jun-Bean Park, Yeonyee E Yoon, Eun-Ah Park, Hyung-Kwan Kim, Whal Lee, Yong-Jin Kim, Goo-Yeong Cho, Dae-Won Sohn, Andreas Greiser, Seung-Pyo Lee
OBJECTIVES: The aim of this study was to evaluate whether native T1 value of the myocardium on cardiac magnetic resonance (CMR) could predict clinical events in patients with significant aortic stenosis (AS). BACKGROUND: Although previous studies have demonstrated the prognostic value of focal fibrosis using late gadolinium enhancement (LGE) by CMR in AS patients, the prognostic implication of diffuse myocardial fibrosis by noninvasive imaging remains unknown. METHODS: A prospective observational longitudinal study was performed in 127 consecutive patients with moderate or severe AS (68...
November 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/29108474/molecular-testing-for-oncogenic-gene-alterations-in-pediatric-thyroid-lesions
#11
Sogol Mostoufi-Moab, Emmanuel Labourier, Lisa Sullivan, Virginia A LiVolsi, Yimei Li, Rui Xiao, Sylvie Beaudenon-Huibregtse, Ken Kazahaya, N Scott Adzick, Zubair W Baloch, Andrew J Bauer
BACKGROUND: Thyroid nodules are less common in pediatric patients (≤18 years) than in adults. The Bethesda System for Reporting Thyroid Cytopathology allows for individual risk stratification, but a significant number of nodules are indeterminate. Incorporating gene mutation panels and gene expression classifiers may aid in pre-operative diagnosis. The overall aim of this study was to assess the prevalence of oncogene alterations in a representative pediatric population and across a broad-spectrum of thyroid tumor diagnoses...
November 6, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29101838/a-molecular-intravascular-ultrasound-contrast-agent-allows-detection-of-activated-platelets-on-the-surface-of-symptomatic-human-plaques
#12
Alexander Maier, Patricia Plaza-Heck, Fabian Meixner, Felix Guenther, Beat A Kaufmann, Mara Kramer, Timo Heidt, Andreas Zirlik, Ingo Hilgendorf, Jochen Reinöhl, Peter Stachon, Peter Bronsert, Ralf Birkemeyer, Irene Neudorfer, Karlheinz Peter, Christoph Bode, Constantin von Zur Mühlen
BACKGROUND AND AIMS: Activated platelets are amongst the most attractive imaging targets in atherosclerosis due to their important role in early processes of atherogenesis and thrombus formation. We developed a molecular intravascular ultrasound (IVUS) approach to detect activated platelets ex vivo on the surface of human plaques, using an IVUS system applied in clinical routine. METHODS: Human carotid endarterectomy specimens were obtained directly from the operating room and exposed to artificial arterial flow conditions for incubation with the contrast agent...
October 24, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29095860/red-cell-distribution-width-as-a-novel-marker-for-predicting-high-risk-from-upper-gastro-intestinal-bleeding-patients
#13
Kyeong Ryong Lee, Sang O Park, Sin Young Kim, Dae Young Hong, Jong Won Kim, Kwang Je Baek, Dong Hyuk Shin, Young Hwan Lee
BACKGROUND: In upper gastrointestinal bleeding (UGIB) patients, early risk stratification allows appropriate therapy that may be helpful for reducing morbidity and mortality. OBJECTIVES: to evaluate the efficacy of red-cell distribution width (RDW) for prediction of high-risk in UGIB patients. METHODS: We conducted a clinical retrospective observational study based on data for UGIB patients from 2012 to 2013. The primary outcome was the high-risk UGIB, defined as those who required urgent intervention and/or 30-days mortality...
2017: PloS One
https://www.readbyqxmd.com/read/29034236/prognostic-value-of-the-new-prostate-cancer-international-society-of-urological-pathology-grade-groups
#14
Anne Offermann, Silke Hohensteiner, Christiane Kuempers, Julika Ribbat-Idel, Felix Schneider, Finn Becker, Marie Christine Hupe, Stefan Duensing, Axel S Merseburger, Jutta Kirfel, Markus Reischl, Verena Lubczyk, Rainer Kuefer, Sven Perner
Gleason grading is the best independent predictor for prostate cancer (PCa) progression. Recently, a new PCa grading system has been introduced by the International Society of Urological Pathology (ISUP) and is recommended by the World Health Organization (WHO). Following studies observed more accurate and simplified grade stratification of the new system. Aim of this study was to compare the prognostic value of the new grade groups compared to the former Gleason Grading and to determine whether re-definition of Gleason Pattern 4 might reduce upgrading from prostate biopsy to radical prostatectomy (RP) specimen...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28978106/a-prospective-appraisal-of-preoperative-body-mass-index-in-d2-resected-patients-with-non-metastatic-gastric-carcinoma-and-siewert-type-ii-iii-adenocarcinoma-of-esophagogastric-junction-results-from-a-large-scale-cohort
#15
Lei Huang, Zhi-Jian Wei, Tuan-Jie Li, Yu-Ming Jiang, A-Man Xu
OBJECTIVE: To prospectively investigate associations of presurgical body mass index (BMI) with clinicopathological factors and its prognostic significance in radically D2-resected patients with non-metastasized gastric cancer (GC) and Siewert type II/III adenocarcinoma of esophagogastric junction (AEG). METHODS: A large prospective cohort consisting of radically-resected GC and AEG patients was analyzed. Follow-up was successful in 671 out of 700 patients, who were categorized into underweight (BMI<18...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28969608/positive-surgical-margins-and-biochemical-recurrence-following-minimally-invasive-radical-prostatectomy-an-analysis-of-outcomes-from-a-uk-tertiary-referral-centre
#16
Ashwin Sachdeva, Rajan Veeratterapillay, Antonia Voysey, Katherine Kelly, Mark I Johnson, Jonathan Aning, Naeem A Soomro
BACKGROUND: Positive surgical margins are a strong prognostic marker of disease outcome following radical prostatectomy, though prior evidence is largely from a PSA-screened population. We therefore aim to evaluate the biochemical recurrence in men with positive surgical margins (PSM) after minimally-invasive radical prostatectomy (MIRP) in a UK tertiary centre. METHODS: Retrospective study of men undergoing laparoscopic or robotic-assisted radical prostatectomy between 2002 and 2014...
October 2, 2017: BMC Urology
https://www.readbyqxmd.com/read/28967164/negative-predictive-value-of-dobutamine-stress-echocardiography-for-perioperative-risk-stratification-in-patients-with-cardiac-risk-factors-and-reduced-exercise-capacity-undergoing-non-cardiac-surgery
#17
Gus Go, Kathy T Davies, Cara O'Callaghan, Wendy Senior, Karam Kostner, Narelle Fagermo, Sandhir B Prasad
BACKGROUND: Guidelines recommend functional testing for myocardial ischaemia in the perioperative setting in patients with >1 recognised cardiac risk factors and self-reported reduced exercise capacity. We sought to determine the clinical utility of dobutamine stress echocardiography (DSE) for perioperative risk stratification in patients undergoing major noncardiac surgery. METHODS: Data on 79 consecutive patients undergoing DSE for perioperative risk stratification at a single centre was retrospectively reviewed to determine rates of Major Adverse Cardiac Events (MACE) during the index hospitalisation and 30 days post discharge...
October 2, 2017: Internal Medicine Journal
https://www.readbyqxmd.com/read/28964612/management-of-the-central-compartment-in-differentiated-thyroid-carcinoma
#18
Ryan P Goepfert, Gary L Clayman
Management of differentiated thyroid carcinoma (DTC) is gradually evolving with considerations of de-escalation of treatment and/or active surveillance in a significant proportion of patients on the basis of an improved understanding of the long-term disease and functional outcomes from both surgical and non-surgical approaches. This is fueled by improved risk stratification using clinicopathologic prognostic factors as determined through high resolution ultrasound and fine needle aspiration cytology. This paper discusses general recommendations for preoperative decision-making in the management of the central compartment in DTC with particular reference to micropapillary thyroid carcinoma and encapsulated follicular variant papillary thyroid carcinoma...
September 13, 2017: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28934761/comparison-between-mri-and-pathology-in-the-assessment-of-tumour-regression-grade-in-rectal-cancer
#19
COMPARATIVE STUDY
Francesco Sclafani, Gina Brown, David Cunningham, Andrew Wotherspoon, Larissa Sena Teixeira Mendes, Svetlana Balyasnikova, Jessica Evans, Clare Peckitt, Ruwaida Begum, Diana Tait, Josep Tabernero, Bengt Glimelius, Susana Roselló, Janet Thomas, Jacqui Oates, Ian Chau
BACKGROUND: Limited data exist regarding the correlation between MRI tumour regression grade (mrTRG) and pathological TRG (pTRG) in rectal cancer. METHODS: mrTRG and pTRG were compared in rectal cancer patients from two phase II trials (EXPERT and EXPERT-C). The agreement between radiologist and pathologist was assessed with the weighted κ test while the Kaplan-Meier method was used to estimate survival outcomes. RESULTS: One hundred ninety-one patients were included...
November 7, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28906306/predicting-early-mortality-following-hip-fracture-surgery-the-hip-fracture-estimator-of-mortality-amsterdam-hema
#20
Julian Karres, Noera Kieviet, Jan-Peter Eerenberg, Bart C Vrouenraets
OBJECTIVES: Early mortality following hip fracture surgery is high and pre-operative risk assessment for the individual patient is challenging. A risk model could identify patients in need of more intensive perioperative care, provide insight in the prognosis and allow for risk-adjustment in audits. This study aimed to develop and validate a risk prediction model for 30-day mortality following hip fracture surgery: the Hip fracture Estimator of Mortality Amsterdam (HEMA). METHODS: Data on 1050 consecutive patients undergoing hip fracture surgery between 2004 and 2010 were retrospectively collected and randomly split into a development cohort (746 patients) and validation cohort (304 patients)...
September 11, 2017: Journal of Orthopaedic Trauma
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