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C-11 choline/PET

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https://www.readbyqxmd.com/read/29902200/acrin-6684-multicenter-phase-ii-assessment-of-tumor-hypoxia-in-newly-diagnosed-glioblastoma-using-magnetic-resonance-spectroscopy
#1
Eva-Maria Ratai, Zheng Zhang, James Fink, Mark Muzi, Lucy Hanna, Erin Greco, Todd Richards, Daniel Kim, Ovidiu C Andronesi, Akiva Mintz, Lale Kostakoglu, Melissa Prah, Benjamin Ellingson, Kathleen Schmainda, Gregory Sorensen, Daniel Barboriak, David Mankoff, Elizabeth R Gerstner
A multi-center imaging trial by the American College of Radiology Imaging Network (ACRIN) "A Multicenter, phase II assessment of tumor hypoxia in glioblastoma using 18F Fluoromisonidazole (FMISO) with PET and MRI (ACRIN 6684)", was conducted to assess hypoxia in patients with glioblastoma (GBM). The aims of this study were to support the role of proton magnetic resonance spectroscopic imaging (1H MRSI) as a prognostic marker for brain tumor patients in multi-center clinical trials. Seventeen participants from four sites had analyzable 3D MRSI datasets acquired on Philips, GE or Siemens scanners at either 1...
2018: PloS One
https://www.readbyqxmd.com/read/29859737/preoperative-staging-with-11-c-choline-pet-ct-is-adequately-accurate-in-patients-with-very-high-risk-prostate-cancer
#2
Riccardo Schiavina, Lorenzo Bianchi, Federico Mineo Bianchi, Marco Borghesi, Cristian Vincenzo Pultrone, Hussam Dababneh, Paolo Castellucci, Francesco Ceci, Cristina Nanni, Caterina Gaudiano, Michelangelo Fiorentino, Angelo Porreca, Francesco Chessa, Andrea Minervini, Stefano Fanti, Eugenio Brunocilla
PURPOSE: To evaluate the accuracy of 11 C-choline positron emission tomography (PET)/computed tomography (CT) for nodal staging of prostate cancer (PCa) in different populations of high-risk patients. PATIENTS AND METHODS: We evaluated 262 individuals with intermediate- or high-risk PCa submitted to radical prostatectomy and extended pelvic lymph node dissection. Within men with high-risk disease, we identified a subgroup of individuals harboring very high-risk (VHR, n = 28) disease: clinical stage ≥ T2c and more than 5 cores with Gleason score 8-10; primary biopsy Gleason score of 5; 3 high-risk features; or prostate-specific antigen ≥ 30 ng/mL...
May 30, 2018: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/29794161/fluorocholine-transport-mediated-by-the-organic-cation-transporter-2-oct2-slc22a2-implication-for-imaging-of-kidney-tumors
#3
Michele Visentin, Angelo Torozi, Zhibo Gai, Stephanie Hausler, Chao Li, Christian Hiller, Peter H Schraml, Holger Moch, Gerd A Kullak-Ublick
[18 F]fluorocholine is the fluorinated analogue of [11 C]choline and is used in positron emission tomography (PET) to monitor tumor metabolic activity. While important to optimize its use and expand the clinical indications, the molecular determinants of fluorocholine cellular uptake are poorly characterized. Here, we described the influx kinetics of fluorocholine mediated by the organic cation transporter 2 (OCT2, SLC22A2) and compared with that of choline. Then, we characterized the expression pattern of OCT2 in renal cell carcinoma (RCC)...
May 24, 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29782606/-68-ga-psma-and-11-c-choline-comparison-using-a-tri-modality-pet-ct-mri-3-0-t-system-with-a-dedicated-shuttle
#4
Omar Alonso, Gerardo Dos Santos, Margarita García Fontes, Henia Balter, Henry Engler
Background: The aim of this study was to prospectively compare the detection rate of 68 Ga-PSMA versus 11 C-Choline in men with prostate cancer with biochemical recurrence and to demonstrate the added value of a tri-modality PET/CT-MRI system. Methods: We analysed 36 patients who underwent both 11 C-Choline PET/CT and 68 Ga-PSMA PET/CT scanning within a time window of 1-2 weeks. Additionally, for the 68 Ga-PSMA scan, we used a PET/CT-MRI (3.0 T) system with a dedicated shuttle, acquiring MRI images of the pelvis...
2018: European journal of hybrid imaging
https://www.readbyqxmd.com/read/29664244/the-role-of-68ga-psma-pet-ct-scan-in-biochemical-recurrence-after-primary-treatment-for-prostate-cancer-a-systematic-review-of-literature
#5
Ahmed Eissa, Ahmed El Sherbiny, Rafael F Coelho, Jens Rassweiler, John W Davis, Francesco Porpiglia, Vipul R Patel, Napoleone Prandini, Salvatore Micali, Maria C Sighinolfi, Stefano Puliatti, Bernardo Rocco, Giampaolo Bianchi
INTRODUCTION: Recurrence after primary treatment of prostate cancer is one of the major challenges facing urologists. Biochemical recurrence is not rare and occurs in up to one third of the patients undergoing radical prostatectomy. Management of biochemical recurrence is tailored according to the site and the burden of recurrence. Therefore, developing an imaging technique to early detect recurrent lesions represents an urgent need. Positron emission tomography (PET) of 68Ga-labelled prostate-specific membrane antigen (68Ga-PSMA) is an emerging imaging modality that seems to be a promising tool with capability to localize recurrent prostate cancer...
April 17, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29626123/-11-c-choline-pharmacokinetics-in-recurrent-prostate-cancer
#6
Milan Grkovski, Karem Gharzeddine, Peter Sawan, Heiko Schoder, Laure Michaud, Wolfgang Andreas Weber, John Laurence Humm
The aim of this study was to investigate the value of pharmacokinetic modeling for quantifying 11 C-choline uptake in patients with recurrent prostate cancer. Methods: 194 patients with clinical suspicion of recurrent prostate cancer underwent 11 C-choline dynamic positron emission tomography over the pelvic region (0-8-min), followed by 6 min static acquisition at ~25 min post-injection. Regions of interest (ROIs) were drawn over sites of disease identified by a radiologist with experience in nuclear medicine...
April 6, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29518282/positron-emission-tomography-guided-magnetic-resonance-spectroscopy-in-alzheimer-disease
#7
Nasim Sheikh-Bahaei, S Ahmad Sajjadi, Roido Manavaki, Mary McLean, John T O'Brien, Jonathan H Gillard
OBJECTIVE: To determine whether the level of metabolites in magnetic resonance spectroscopy (MRS) is a representative marker of underlying pathological changes identified in positron emission tomographic (PET) images in Alzheimer disease (AD). METHODS: We performed PET-guided MRS in cases of probable AD, mild cognitive impairment (MCI), and healthy controls (HC). All participants were imaged by 11 C-Pittsburgh compound B (11 C-PiB) and 18 F-fluorodeoxyglucose (18 F-FDG) PET followed by 3T MRS...
April 2018: Annals of Neurology
https://www.readbyqxmd.com/read/29515407/tiny-obturator-node-metastasis-from-prostate-cancer-not-shown-by-fdg-pet-ct-ct-or-mri-detected-by-11-c-choline-pet-ct
#8
Kazuhiro Kitajima, Shingo Yamamoto, Soichi Odawara, Yusuke Kawanaka, Yukako Nakanishi, Takahiko Hashimoto, Yusuke Yamada, Toru Suzuki, Akihiro Kanematsu, Michio Nojima, Neinei Kimura, Masataka Zouzumi, Seiichi Hirota, Koichiro Yamakado
We report a 65-year-old male with histopathologically proven prostate cancer and multiple pelvic node metastases using a robotic-assisted radical prostatectomy procedure plus extended pelvic lymph node dissection. Positron emission tomography (PET) scan findings demonstrated a moderate accumulation of 11 C-choline in a metastatic left obturator node sized 8 × 8 mm, though only a faint uptake of fluorodeoxyglucose (FDG) was noted. 11 C-choline PET/computed tomography (CT) may be useful for the diagnosis of a tiny metastatic lymph node not demonstrated by CT, magnetic resonance imaging, or FDG-PET/CT and to determine the need for an extended pelvic lymph node dissection...
January 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29453702/the-relationship-between-local-recurrences-and-distant-metastases-in-prostate-cancer-can-11-c-choline-pet-ct-contribute-to-understand-the-link
#9
Giampiero Giovacchini, Andrea Ciarmiello, Elisabetta Giovannini, Andrei Fodor, Cesare Cozzarini, Paola Mapelli, Elena Incerti, Nadia Di Muzio, Luigi Gianolli, Maria Picchio
PURPOSE: Previous studies in prostate cancer (PCa) patients tried to correlate the onset of local recurrence (LR) with the development of distant metastases and formulated, based on theoretical and experimental data, hypotheses linking the two events. We aimed to address this issue with 11 C-choline positron emission tomography/computed tomography (PET/CT). METHODS: This retrospective study included 491 PCa patients previously treated with radical prostatectomy who had undergone 11 C-choline PET/CT owing to biochemical failure...
June 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29444756/local-recurrence-on-pet-ct-with-11-c-choline-following-brachytherapy-for-prostate-cancer-tracer-uptake-pattern
#10
J R Garcia, P Bassa, M Soler, F J Alvarez Moro, T Blanch, E Riera
No abstract text is available yet for this article.
February 11, 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29313360/diagnostic-bone-imaging-in-patients-with-prostate-cancer-patient-experience-and-acceptance-of-naf-pet-ct-choline-pet-ct-whole-body-mri-and-bone-spect-ct
#11
Eva Dyrberg, Emil L Larsen, Helle W Hendel, Henrik S Thomsen
Background Patient acceptance is an important factor when implementing imaging methods in clinical practice in line with availability, diagnostic accuracy, and cost-effectiveness. Purpose To investigate patient experience and acceptance regarding18F-sodium fluoride (NaF) positron emission tomography/computed tomography (PET/CT), 11 C-choline-PET/CT, whole-body magnetic resonance imaging (WB-MRI), and 99mTc-hydroxymethane diphosphonate (HDP) single photon emission/computed tomography (SPECT/CT). Material and Methods One hundred and forty-nine patients with prostate cancer filled in a questionnaire regarding their experience of the imaging procedures they had been undergoing as part of a diagnostic accuracy study...
January 1, 2018: Acta Radiologica
https://www.readbyqxmd.com/read/29152237/analysis-of-recipes-of-home-prepared-diets-for-dogs-and-cats-published-in-portuguese
#12
Vivian Pedrinelli, Márcia de O S Gomes, Aulus C Carciofi
The present study evaluated recipes of home-prepared diets for dogs and cats published in Portuguese. A total of 106 diets were evaluated: eighty for dogs, twenty-four for cats and two intended for both species. A commercial software package was used to analyse the diets, and an ingredient chemical composition database was built based on the Brazilian Tables of Food Composition and United States Department of Agriculture Nutrient Database. The estimated chemical composition of each recipe was compared with the Nutritional Guidelines for Complete and Complementary Pet Food for Cats and Dogs (Fédération Européenne de L'industrie des Aliments Pour Animaux Familiers; FEDIAF, 2014) recommendations for maintenance (as units/MJ)...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/29140118/-11-c-choline-pet-ct-for-detection-and-localization-of-parathyroid-adenomas
#13
Ahmad Parvinian, Erica L Martin-Macintosh, Ajit H Goenka, Jolanta M Durski, Brian P Mullan, Brad J Kemp, Geoffrey B Johnson
OBJECTIVE: The purpose of this study is to determine the efficacy of 11 C-choline PET/CT for the detection of parathyroid adenomas by retrospectively reviewing a large patient population. MATERIALS AND METHODS: In this single-institution retrospective study, 7088 11 C-choline PET/CT scans performed of 2933 men with prostate cancer from January 2005 through February 2016 were evaluated. Patients with suspected parathyroid adenomas were identified through a review of the electronic medical record and relevant imaging...
February 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29137875/contribution-of-11-c-choline-pet-ct-in-prostate-carcinoma-biochemical-relapse-with-serum-psa-level-below-1-ng-ml
#14
F J Gómez-de la Fuente, I Martínez-Rodríguez, M de Arcocha-Torres, R Quirce, J Jiménez-Bonilla, N Martínez-Amador, I Banzo
OBJECTIVE: 11 C-choline PET/CT has demonstrated good results in the restaging of prostate cancer (PCa) with high serum prostate specific antigen (PSA), but its use in patients with low serum PSA is controversial. Our aim was to evaluate the contribution of 11 C-choline PET/CT in patients with PCa, biochemical relapse and PSA <1 ng/ml. MATERIAL AND METHOD: Fifty consecutive patients (mean age: 65.9±5.6 years) with biochemical relapse of PCa and serum PSA <1ng/ml were evaluated retrospectively...
May 2018: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/29133278/imaging-for-the-detection-of-locoregional-recurrences-in-biochemical-progression-after-radical-prostatectomy-a-systematic-review
#15
REVIEW
Kristina Sandgren, Philippe Westerlinck, Joakim H Jonsson, Lennart Blomqvist, Camilla Thellenberg Karlsson, Tufve Nyholm, Piet Dirix
CONTEXT: Local and regional recurrence after radical prostatectomy (RP) can be treated using salvage radiotherapy (SRT). If the recurrence can be delineated on diagnostic imaging, this could allow for increasingly individualized SRT. OBJECTIVE: This systematic review aimed at evaluating the evidence regarding the usefulness of positron emission tomography (PET) and magnetic resonance imaging (MRI) in identifying local and regional recurrences, with the aim to further individualize the SRT treatment...
November 10, 2017: European Urology Focus
https://www.readbyqxmd.com/read/29104741/lymph-node-imaging-in-initial-staging-of-prostate-cancer-an-overview-and-update
#16
REVIEW
Jessica G Zarzour, Sam Galgano, Jonathan McConathy, John V Thomas, Soroush Rais-Bahrami
Accurate nodal staging at the time of diagnosis of prostate cancer is crucial in determining a treatment plan for the patient. Pelvic lymph node dissection is the most reliable method, but is less than perfect and has increased morbidity. Cross sectional imaging with computed tomography (CT) and magnetic resonance imaging (MRI) are non-invasive tools that rely on morphologic characteristics such as shape and size of the lymph nodes. However, lymph nodes harboring metastatic disease may be normal sized and non-metastatic lymph nodes may be enlarged due to reactive hyperplasia...
October 28, 2017: World Journal of Radiology
https://www.readbyqxmd.com/read/28969081/report-on-the-development-and-application-of-pet-ct-in-mainland-china
#17
Yumei Chen, Ruohua Chen, Xiang Zhou, Jianjun Liu, Gang Huang
PURPOSE: To examine the development and application of systems combining positron emission and x-ray-computed tomography systems (PET/CTs) in mainland China. METHODS: Using a questionnaire, we surveyed Chinese medical institutions on a variety topics relating to their PET/CT systems and its use. The respondents had PET/CTs installed and in clinical use before 31 December 2015. We examined the clinical scenarios to which Chinese PET/CTs were applied by reviewing the related Chinese and international literature from the start of 1995 to the end of 2013; these papers were found by searching the Wanfang and PubMed databases, respectively...
September 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/28916273/identification-of-recurrence-sites-following-post-prostatectomy-treatment-for-prostate-cancer-using-11-c-choline-positron-emission-tomography-and-multiparametric-pelvic-magnetic-resonance-imaging
#18
Avinash Nehra, William P Parker, Rimki Haloi, Sean S Park, Lance A Mynderse, Val J Lowe, Brian J Davis, J Fernando Quevedo, Geoffrey B Johnson, Eugene D Kwon, R Jeffrey Karnes
PURPOSE: We describe anatomical sites of recurrence in patients with prostate cancer who had biochemical recurrence following radical prostatectomy and who received radiotherapy and/or androgen deprivation therapy postoperatively. We performed 11 C-choline positron emission tomography/computerized tomography and multiparametric magnetic resonance imaging. MATERIALS AND METHODS: After radiotherapy and/or androgen deprivation therapy patients who underwent radical prostatectomy were evaluated by 11 C-choline positron emission tomography/computerized tomography and multiparametric magnetic resonance imaging to determine recurrence patterns and clinicopathological features...
September 12, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28878443/diagnostic-performance-of-11-c-choline-pet-ct-and-bone-scintigraphy-in-the-detection-of-bone-metastases-in-patients-with-prostate-cancer
#19
Kazuhiro Kitajima, Kazuhito Fukushima, Shingo Yamamoto, Takashi Kato, Soichi Odawara, Haruyuki Takaki, Masayuki Fujiwara, Koichiro Yamakado, Yukako Nakanishi, Akihiro Kanematsu, Michio Nojima, Shozo Hirota
The aim of this study was to compare 11C-choline PET/CT and bone scintigraphy (BS) for detection of bone metastases in patients with prostate cancer. Twenty-one patients with histologically proven prostate cancer underwent 11C-choline PET/CT and BS before (n = 4) or after (n = 17) treatment. Patient-, region-, and lesion-based diagnostic performances of bone metastasis of both 11C-choline PET/CT and BS were evaluated using a five-point scale by two experienced readers. Bone metastases were present in 11 (52...
August 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28803358/prospective-head-to-head-comparison-of-11-c-choline-pet-mr-and-11-c-choline-pet-ct-for-restaging-of-biochemical-recurrent-prostate-cancer
#20
Matthias Eiber, Isabel Rauscher, Michael Souvatzoglou, Tobias Maurer, Markus Schwaiger, Konstantin Holzapfel, Ambros J Beer
PURPOSE: Whole-body integrated (11)C-choline PET/MR might provide advantages compared to (11)C-choline PET/CT for restaging of prostate cancer (PC) due to the high soft-tissue contrast and the use of multiparametric MRI, especially for detection of local recurrence and bone metastases. MATERIALS AND METHODS: Ninety-four patients with recurrent PC underwent a single-injection/dual-imaging protocol with contrast-enhanced PET/CT followed by fully diagnostic PET/MR...
December 2017: European Journal of Nuclear Medicine and Molecular Imaging
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