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C-11 choline/PET

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https://www.readbyqxmd.com/read/28725583/positron-emission-tomography-pet-in-primary-prostate-cancer-staging-and-risk-assessment
#1
REVIEW
Sandra Bednarova, Maria L Lindenberg, Maria Vinsensia, Chiara Zuiani, Peter L Choyke, Baris Turkbey
Prostate cancer (PCa) is one of the few neoplasms that are not well served by 18F-Fluorodeoxyglucose (FDG) positron emission tomography (PET). As a result, a number of PET tracers have been developed to target particular biological features of PCa. Such agents can be used for diagnosis, staging, identification of biochemical recurrence (BCR) and evaluation of metastatic disease. Here, we focus on primary disease and local staging. To date, magnetic resonance imaging (MRI) has proven superior to PET in the imaging of primary PCa...
June 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28721304/imaging-features-of-paget-s-disease-on-11-c-choline-pet-ct
#2
Cameron E Leitch, Ajit H Goenka, Benjamin M Howe, Stephen M Broski
The purpose of this study was to investigate the appearance of Paget's disease (PD) on (11)C choline PET/CT and correlate these findings to serum alkaline phosphatase (ALP) level and skeletal scintigraphy. With IRB approval, our institutional (11)C choline PET/CT database (9/2005-6/2015) was searched for patients with PD. Site of osseous involvement, CT appearance, and multiple semi-quantitative measures were measured and correlated with ALP and degree of uptake on bone scan. Our search identified 10 males (mean age 79...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28626263/-11-c-choline-positive-but-18-f-fdg-negative-pancreatic-metastasis-from-renal-cell-carcinoma-on-pet
#3
Kazuhiro Kitajima, Kazuhito Fukushima, Shingo Yamamoto, Takashi Kato, Soichi Odawara, Haruyuki Takaki, Kaoru Kobayashi, Toshiko Yamano, Koichiro Yamakado, Yukako Nakanishi, Akihiro Kanematsu, Michio Nojima, Kazuhiro Suzumura, Etsuro Hatano, Jiro Fujimoto, Takako Kihara, Keiji Nakasho, Seiichi Hirota, Shozo Hirota
Choline is a new PET tracer, which uptake may occur via a choline-specific transporter protein and be accelerated during the proliferation of tumor cells. We report a 61-year-old woman with a metastatic pancreatic tumor from renal cell carcinoma, measuring 35×40 mm. PET scans demonstrated accumulation of (11)C-choline in the metastatic pancreatic tumor, but no accumulation of (18)F-FDG. Choline PET/CT may play a useful and complementary imaging modality, especially when FDG-PET/CT does not show expected findings or when the evaluation of tumor viability is needed, in patients with renal cell carcinoma...
February 2017: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28575697/pet-ct-with-18-f-choline-physiological-whole-bio-distribution-in-male-and-female-subjects-and-diagnostic-pitfalls-on-1000-prostate-cancer-patients-18-f-choline-pet-ct-bio-distribution-and-pitfalls-a-southern-italian-experience
#4
Ferdinando Calabria, Agostino Chiaravalloti, Carmelo Cicciò, Vincenzo Gangemi, Domenico Gullà, Federico Rocca, Gianpasquale Gallo, Giuseppe Lucio Cascini, Orazio Schillaci
INTRODUCTION: The (11)C/(18)F-choline is a PET/CT radiopharmaceutical useful in detecting tumors with high lipogenesis. (11)C/(18)F-choline uptake can occur in physiological conditions or tumors. The knowledge of its bio-distribution is essential to recognize physiologic variants or diagnostic pitfalls. Moreover, few information are available on the bio-distribution of this tracer in female patients. Our aim was to discuss some documented (18)F-choline PET/CT pitfalls in prostate cancer patients...
August 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28458384/clinical-utility-of-positron-emission-tomography-in-patients-with-malignant-glioma
#5
Hirohito Yano, Jun Shinoda, Toru Iwama
Positron emission tomography (PET) is being increasingly utilized for the management of brain tumors. Herein, we primarily review our previous studies on the use of PET in glioma that utilize three types of tracers: (11)C-methionine (MET), (11)C-choline, and (18)F-fluorodeoxyglucose. These studies included aspects such as tumor behavior, diagnosis, grade of malignancy, spread and invasion, viability, and genetic deletions; moreover, they also evaluated PET as a tool for planning radiation therapy (RT) and determining its outcome...
May 1, 2017: Neurologia Medico-chirurgica
https://www.readbyqxmd.com/read/28409220/pet-and-pet-ct-with-radiolabeled-choline-in-prostate-cancer-a-critical-reappraisal-of-20-years-of-clinical-studies
#6
REVIEW
Giampiero Giovacchini, Elisabetta Giovannini, Rossella Leoncini, Mattia Riondato, Andrea Ciarmiello
We here aim to provide a comprehensive and critical review of the literature concerning the clinical applications of positron emission tomography/computed tomography (PET/CT) with radiolabeled choline in patients with prostate cancer (PCa). We will initially briefly summarize the historical context that brought to the synthesis of [(11)C]choline, which occurred exactly 20 years ago. We have arbitrarily grouped the clinical studies in three different periods, according to the year in which they were published and according to their relation with their applications in urology, radiotherapy and oncology...
April 14, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28333548/utility-of-pet-ct-after-cryoablation-for-early-identification-of-local-tumor-progression-in-osseous-metastatic-disease
#7
Ann T Packard, Stephen M Broski, Matthew R Callstrom, Thomas D Atwell, Grant D Schmit, John J Schmitz, Jonathan M Morris, Christopher H Hunt, A Nicholas Kurup
OBJECTIVE: The purpose of this study is to evaluate the utility of combined PET/CT for the detection of early local tumor progression after cryoablation of bone metastases. MATERIALS AND METHODS: A retrospective single-institution review revealed 61 consecutive patients with 80 separate bone metastases treated with cryoablation who were evaluated with a preablation PET/CT and at least two postablation PET/CT examinations between September 2007 and July 2015. Patients were excluded if they had local therapy or pathologic fracture after ablation...
March 23, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28302759/preclinical-evaluation-of-11-c-sarcosine-as-a-substrate-of-proton-coupled-amino-acid-transporters-and-first-human-application-in-prostate-cancer
#8
Morand Piert, Xia Shao, David M Raffel, Mathew S Davenport, Jeffrey Montgomery, Lakshmi Kunju, Brian G Hockley, Javed Siddiqui, Peter J H Scott, Arul Chinnaiyan, Thekkelnaycke Rajandiran
Sarcosine is a known substrate of proton-coupled amino acid transporters (PAT), which are overexpressed in selected tissues and solid tumors. Sarcosine, an N-methyl derivative of the amino acid glycine and a metabolic product of choline, plays an important role for prostate cancer aggressiveness and progression. Methods: Carbon-11 radiolabeled sarcosine ((11)C-sarcosine) was tested as a new positron emission tomography (PET) imaging probe in comparison with (11)C-choline in two prostate cancer tumor xenograft models (DU-145 and PC-3)...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28267448/imaging-of-prostate-cancer-using-11-c-choline-pet-computed-tomography
#9
REVIEW
Paolo Castellucci, Francesco Ceci, Stefano Fanti
This article reviews the role of (11)C-choline-PET/computed tomography (CT) in patients with prostate cancer for diagnosis, staging, and restaging the disease in case of biochemical recurrence after primary treatment. The main application of this imaging procedure is restaging of the disease in case of biochemical recurrence. (11)C-Choline-PET/CT proved its value for metastases-directed salvage therapies and for monitoring therapy response in castration-resistant patients. Prostate-specific antigen and prostate-specific antigen kinetics values confirmed their correlation with (11)C-choline PET/CT sensitivity...
April 2017: PET Clinics
https://www.readbyqxmd.com/read/28258616/focal-salvage-high-intensity-focused-ultrasound-in-radiorecurrent-prostate-cancer
#10
Abi Kanthabalan, Max Peters, Marco Van Vulpen, Neil McCartan, Richard Graham Hindley, Amr Emara, Caroline M Moore, Manit Arya, Mark Emberton, Hashim Uddin Ahmed
OBJECTIVE: To assess short- to medium-term cancer control rates and side effects of focal salvage high- intensity focused ultrasound (HIFU). MATERIALS AND METHODS: A retrospective registry analysis identified 150 men who underwent focal salvage HIFU (FS-HIFU) (Sonablate 500) between November 2006 and August 2015. Metastatic disease was excluded by nodal assessment on the pelvic MRI, a radioisotope bone scan and positron-emission tomography (PET) imaging (choline-18F-fluorodeoxyglucose PET or choline PET-CT)...
March 4, 2017: BJU International
https://www.readbyqxmd.com/read/28123863/performance-characteristics-and-relationship-of-psa-value-kinetics-on-carbon-11-acetate-pet-ct-imaging-in-biochemical-relapse-of-prostate-cancer
#11
Fabio D Almeida, Chi-Kwan Yen, Mark C Scholz, Richard Y Lam, Jeffrey Turner, Larry L Bans, Robert Lipson
An elevated serum prostate-specific antigen (PSA) level alone cannot distinguish between local-regional recurrences and distant metastases after treatment with curative intent. With available salvage treatments, it has become important to localize the site of recurrence. (11)C-Acetate PET/CT was performed in patients with rising PSA, with statistical analysis of detection rates, sites/location of detection, PSA kinetics and comparison with other tracers (FDG and Choline). Correlation to biopsy, subsequent imaging and PSA response to focal treatment was also performed...
2017: American Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28005153/-significance-of-psma-imaging-in-prostate-cancer
#12
C Gasch, C Düwel, K Kopka, C Kratochwil, M Vinsensia, M Eiber, T Maurer, U Haberkorn, B Hadaschik, F L Giesel
BACKGROUND: Prostate cancer (PCa) is one of the most common malignancies of men in developed countries. To improve clinical diagnostics of PCa, (68)Ga-PSMA-11 was recently introduced as a new PET tracer. (68)Ga-PSMA-11 is able to specifically bind to the prostate-specific membrane antigen (PSMA), which is upregulated on the surface of prostate cancer cells in most patients. OBJECTIVES: To analyse the current significance of (68)Ga-PSMA-11 PET imaging in prostate cancer in relation to staging of men with initial diagnosis, biochemical recurrence and metastatic disease...
January 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/27920703/-11-c-choline-avid-but-18-f-fdg-nonavid-prostate-cancer-with-lymph-node-metastases-on-positron-emission-tomography
#13
Kazuhiro Kitajima, Kazuhito Fukushima, Shingo Yamamoto, Toshiko Yamano, Haruyuki Takaki, Koichiro Yamakado, Yukako Nakanishi, Akihiro Kanematsu, Michio Nojima, Shozo Hirota
Choline is a new positron emission tomography (PET) tracer useful for detection of prostate cancer and metastatic lesions. We report a 70-year-old man with prostate cancer and multiple abdominal, pelvic, and inguinal node metastases. PET scans demonstrated accumulation of (11)C-choline in the primary tumor and lymph node metastases but no accumulation of (18)F-FDG. Choline PET/computed tomography may be useful for diagnosis of advanced prostate cancer with suspected metastatic lesions and treatment planning...
September 2016: Case Reports in Oncology
https://www.readbyqxmd.com/read/27914899/reply-from-authors-re-alberto-bossi-nicolas-mottet-pierre-blanchard-choline-positron-emission-tomography-computed-tomography-for-selection-of-patients-for-salvage-strategies-after-primary-local-treatment-of-prostate-cancer-and-rising-prostate-specific-antigen
#14
EDITORIAL
https://www.readbyqxmd.com/read/27825431/pet-tracers-beyond-fdg-in-prostate-cancer
#15
REVIEW
David M Schuster, Cristina Nanni, Stefano Fanti
Conventional anatomical imaging with CT and MRI has limitations in the evaluation of prostate cancer. PET is a powerful imaging technique, which can be directed toward molecular targets as diverse as glucose metabolism, density of prostate-specific membrane antigen receptors, and skeletal osteoblastic activity. Although 2-deoxy-2-(18)F-FDG-PET is the mainstay of molecular imaging, FDG has limitations in typically indolent prostate cancer. Yet, there are many useful and emerging PET tracers beyond FDG, which provide added value...
November 2016: Seminars in Nuclear Medicine
https://www.readbyqxmd.com/read/27796820/whole-body-diffusion-weighted-magnetic-resonance-imaging-wb-dw-mri-vs-choline-positron-emission-tomography-computed-tomography-choline-pet-ct-for-selecting-treatments-in-recurrent-prostate-cancer
#16
A J Conde-Moreno, G Herrando-Parreño, R Muelas-Soria, J Ferrer-Rebolleda, R Broseta-Torres, M P Cozar-Santiago, F García-Piñón, C Ferrer-Albiach
OBJECTIVE: To determine the effectiveness of whole-body diffusion-weighted magnetic resonance imaging (WB-DW-MRI) in detecting metastases by comparing the results with those from choline-positron emission tomography-computed tomography (choline-PET/CT) in patients with biochemical relapse after primary treatment, and no metastases in bone scintigraphy, CT and/or pelvic MRI, or metastatic/oligometastatic prostate cancer (PCa). Patients with this disease profile who could benefit from treatment with stereotactic body radiation therapy (SBRT) were selected and their responses to these techniques were rated...
May 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/27694174/evaluation-of-prostate-cancer-with-radiolabeled-amino-acid-analogs
#17
REVIEW
David M Schuster, Cristina Nanni, Stefano Fanti
Conventional imaging of prostate cancer has limitations related to the frequently indolent biology of the disease. PET is a functional imaging method that can exploit various aspects of tumor biology to enable greater detection of prostate cancer than can be provided by morphologic imaging alone. Radiotracers that are in use or under investigation for targeting salient features of prostate cancer include those directed to glucose, choline, acetate, prostate-specific membrane antigen, bombesin, and amino acids...
October 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27694172/evaluation-of-prostate-cancer-with-11c-choline-pet-ct-for-treatment-planning-response-assessment-and-prognosis
#18
REVIEW
Francesco Ceci, Paolo Castellucci, Paola Mapelli, Elena Incerti, Maria Picchio, Stefano Fanti
The aim of this review is to report on the value of (11)C-choline PET imaging as a diagnostic procedure for metastasis-directed therapies. Furthermore, the role of (11)C-choline PET/CT as a diagnostic tool for monitoring castration-resistant prostate cancer patients treated with systematic therapy is assessed. Finally, the role of (11)C-choline PET/CT in the prediction of survival in both castration-resistant prostate cancer patients and hormone-naïve patients is investigated.
October 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27694169/evaluation-of-prostate-cancer-with-11c-and-18f-choline-pet-ct-diagnosis-and-initial-staging
#19
REVIEW
Sascha Nitsch, Oliver W Hakenberg, Martin Heuschkel, Desiree Dräger, Guido Hildebrandt, Bernd J Krause, Sarah M Schwarzenböck
Early diagnosis and adequate staging are crucial for the choice of adequate treatment in prostate cancer (PC). Morphologic and functional imaging modalities, such as CT and MRI, have had limited accuracy in the diagnosis and nodal staging of PC. Molecular PET/CT imaging with (11)C- or (18)F-choline-labeled derivatives is increasingly being used, but its role in the diagnosis and initial staging of PC is controversial because of limitations in sensitivity and specificity for the detection of primary PC. For T staging, functional MRI is superior to (11)C- or (18)F-choline PET/CT...
October 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/27660552/synthesis-isolation-and-purification-of-11-c-choline
#20
Marcin Szydło, Michał Jadwiński, Agnieszka Chmura, Kamil Gorczewski, Maria Sokół
[(11)C]-choline is an effective PET tracer used for imaging of neoplastic lesions and metastases of the prostate cancer. However, its production can be a challenge for manufacturers, as it has not yet been described in Polish or European pharmacopoeia. In this study the technical aspects of [(11)C]-choline production are described and detailed process parameters are provided. The quality control procedures for releasing [(11)C]-choline as solutio iniectabilis are also presented. The purity and quality of the radiopharmaceutical obtained according to the proposed method were find to be high enough to safely administrate the radiopharmaceutical to patients...
2016: Contemporary Oncology Współczesna Onkologia
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