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Mets snc

Jacob Hansen-Schwartz, Pierre Nourdine Bouchelouche
INTRODUCTION: The revised Scandinavian Neurotrauma Committee (SNC) guidelines on management of patients with head trauma include an option for measurement of S100B in peripheral blood with 100% sensitivity for neurosurgical intervention. A medical technology assessment was conducted to evaluate any impact of using S100B on the use of computed tomographies (CT) of the brain and admission for observation. MATERIAL AND METHODS: Patients referred for assessment of head injury over a period of 1...
September 2014: Danish Medical Journal
Sören Müller, Katharina Nowak
Altered microRNA (miRNA) expression is a hallmark of many cancer types. The combined analysis of miRNA and messenger RNA (mRNA) expression profiles is crucial to identifying links between deregulated miRNAs and oncogenic pathways. Therefore, we investigated the small non-coding (snc) transcriptomes of nine clear cell renal cell carcinomas (ccRCCs) and adjacent normal tissues for alterations in miRNA expression using a publicly available small RNA-Sequencing (sRNA-Seq) raw-dataset. We constructed a network of deregulated miRNAs and a set of differentially expressed genes publicly available from an independent study to in silico determine miRNAs that contribute to clear cell renal cell carcinogenesis...
2014: BioMed Research International
Hanieh Bagheri Tudashki, Derek N Robertson, Peter W Schiller, Graciela Pineyro
Traditional assays that monitor cAMP inhibition by opioid receptor ligands require second-messenger accumulation over periods of 10-20 minutes. Since receptor regulation occurs within a similar time frame, such assays do not discriminate the actual signal from its modulation. Here we used bioluminescence resonance energy transfer to monitor inhibition of cAMP production by δ-opioid receptor (DOR) agonists in real time. cAMP inhibition elicited by different agonists over a period of 15 minutes was biphasic, with response buildup during the first 6 to 7 minutes, followed by a second phase of response decay or of no further increment...
January 2014: Molecular Pharmacology
Stephen Landy, Rebecca Hoagland, Dakota Hoagland, Jane Saiers, Gena Reuss
OBJECTIVE: Efficacy and tolerability profiles of Treximet [sumatriptan/naproxen sodium combination tablet (SNC)] have been established in clinical trials but have to date been virtually unstudied in pragmatic research. The primary objective of this study was to compare the overall satisfaction of SNC to its monotherapy components, S/N [one 100 mg Imitrex tablet (S) and two Aleve (naproxen sodium) 220 mg tablets, total dose 440 mg (N)] administered concomitantly using the Patient Perception of Migraine Questionnaire -Revised (PPMQ-R)...
September 2013: Therapeutic Advances in Neurological Disorders
Elizabeth A Mazzio, Fran Close, Karam F A Soliman
Future therapeutic intervention that could effectively decelerate the rate of degeneration within the substantia nigra pars compacta (SNc) could add years of mobility and reduce morbidity associated with Parkinson's disease (PD). Neurodegenerative decline associated with PD is distinguished by extensive damage to SNc dopaminergic (DAergic) neurons and decay of the striatal tract. While genetic mutations or environmental toxins can precipitate pathology, progressive degenerative succession involves a gradual decline in DA neurotransmission/synaptic uptake, impaired oxidative glucose consumption, a rise in striatal lactate and chronic inflammation...
2011: International Journal of Molecular Sciences
I Lecoq, N Marie, Ph Jauzac, S Allouche
Among the different mechanisms underlying opioid tolerance, receptor desensitization would represent a major cellular adaptation process in which the role of receptor internalization is still a matter of debate. In the present study, we examined desensitization of the human delta-opioid receptor (hDOR) produced by endogenous opioid peptides Leu-enkephalin (Tyr-Gly-Gly-Phe-Leu) and Met-enkephalin (Tyr-Gly-Gly-Phe-Met), and the contribution of internalization in this process. Results obtained with natural peptides were compared with those produced by a synthetic opioid agonist, SNC-80 [(+)-4-[(alphaR)-alpha-((2S,5R)-4-allyl-2,5-dimethyl-1-piperazinyl)-3-methoxybenzyl]-N,N-diethylbenzamide)...
August 2004: Journal of Pharmacology and Experimental Therapeutics
Jordan Geller, Ivor Wharf, Francine Bélanger-Gariépy, Anne Marie Lebuis, Ian S Butler, Denis F R Gilson
Chlorotris(2,4,6-trimethylphenyl)tin(IV), crystallizes from ethanol as solvent-free needles, [Sn(C(9)H(11))(3)Cl], (I), and as the hemisolvate, [Sn(C(9)H(11))(3)Cl].0.5C(2)H(6)O, (II). The asymmetric unit in (I) has three independent molecules, whereas in (II), there are two [Sn(C(9)H(11))(3)Cl] molecules together with one ethanol molecule. In the unit cell of (II), the ethanol molecules lie in channels between stacks of (Mes)(3)SnCl molecules (Mes is 2,4,6-trimethylphenyl) and each ethanol molecule is disordered (0...
September 2002: Acta Crystallographica. Section C, Crystal Structure Communications
J L Bishop, C M Pieters, R G Burns
Spectroscopic analyses show that Fe(3+)-doped smectites prepared in the laboratory exhibit important similarities to the soils on Mars. Ferrihydrite has been identified as the interlayer ferric component in Fe(3+)-doped smectites by a low quadrupole splitting and magnetic field strength of approximately 48 tesla in Mossbauer spectra measured at 4.2 K, as well as a crystal field transition at 0.92 micrometer. Ferrihydrite in these smectites explains features in the visible-near infrared region that resemble the energies and band strengths of features in reflectance spectra observed for several bright regions on Mars...
1993: Geochimica et Cosmochimica Acta
M Nebel, K Marczewski, K Finke
In a retrospective study over three years, 23 patients were provided with a swan-neck Tenckhoff catheter (SNC) and 49 patients (control group) with a straight Tenckhoff catheter (STC) at the beginning of CAPD and were observed over a follow-up period of 608 patient-months. The aim of the study was to examine the reduction of complications in the course of CAPD with SNC resulting from technical causes, such as catheter dislocations, infections at the catheter's point of exit, the tunnel and the peritoneum. The causes of renal insufficiency, the reasons for choosing CAPD as a dialytic procedure, the causes of catheter loss as well as the frequency of infections associated with CAPD were analyzed...
1991: Advances in Peritoneal Dialysis
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