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Harleen Chhabra, Venkataram Shivakumar, Manjula Subbanna, Sunil V Kalmady, Anushree Bose, Sri Mahavir Agarwal, Vanteemar S Sreeraj, Damodharan Dinakaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramanian
OBJECTIVE: Recent observations demonstrate a significant ameliorative effect of add-on transcranial direct current stimulation (tDCS) on auditory verbal hallucinations (AVHs) in schizophrenia. Of the many SNPs, NRG1 rs35753505 and catechol-o-methyl transferase (COMT) rs4680 polymorphisms have shown to have a strong association with neuroplasticity effect in schizophrenia. METHODS: Schizophrenia patients (n=32) with treatment resistant auditory hallucinations were administered with an add-on tDCS...
March 21, 2018: Acta Neuropsychiatrica
K M Shivakumar, Snehal Patil, Vidya Kadashetti, Vaishali Raje
Introduction: The individuals suffering from various disabilities form a considerable proportion of the community. The psychological reactions associated with a deformity can be devastating to the disabled, parents, caregivers, and family which often lead to attitudes of hopelessness in the lives of these disabled individuals. Objectives: To assess the oral health status and treatment needs among 5-12-year-old children attending special school in Western Maharashtra, India...
January 2018: International Journal of Applied and Basic Medical Research
Shivakumar Subbanna, Nagaraja N Nagre, Madhu Shivakumar, Vikram Joshi, Delphine Psychoyos, Abdullah Kutlar, Nagavedi S Umapathy, Balapal S Basavarajappa
Alcohol exposure can affect brain development, leading to long-lasting behavioral problems, including cognitive impairment, which together is defined as fetal alcohol spectrum disorder (FASD). However, the fundamental mechanisms through which this occurs are largely unknown. In this study, we report that the exposure of postnatal day 7 (P7) mice to ethanol activates caspase-3 via cannabinoid receptor type-1 (CB1R) in neonatal mice and causes a reduction in methylated DNA binding protein (MeCP2) levels. The developmental expression of MeCP2 in mice is closely correlated with synaptogenesis and neuronal maturation...
2018: Frontiers in Molecular Neuroscience
Perumal Vivekanandhan, Thangaraj Kavitha, Sengodan Karthi, Sengottayan Senthil-Nathan, Muthugoundar Subramanian Shivakumar
Microbial-based pest control is an attractive alternative to chemical insecticides. The present study sought to evaluate the toxicity of the entomopathogenic fungus Beauveria bassiana -28 ethyl acetate extracts on different larval stages and pupae of Culex quinquefasciatus mosquitoes. B. bassiana -28 ethyl acetate mycelial extracts produced mosquitocidal activity against larvae and pupae which was comparable to that of the commercial insecticide B. bassiana -22 extract. The LC50 (lethal concentration that kills 50% of the exposed larvae) values of B...
March 3, 2018: International Journal of Environmental Research and Public Health
Perumal Vivekanandhan, Raji Venkatesan, Govindaraju Ramkumar, Sengodan Karthi, Sengottayan Senthil-Nathan, Muthugoundar Subramanian Shivakumar
Botanical metabolites are increasingly realized as potential replacements to chemical insecticides. In the present study, Acacia nilotica seed essential oil and seed pod solvent extracts were tested for bioefficacy against three important types of mosquitoes. Mortality was recorded 24 h post-treatment, while smoke toxicity of adult mosquitoes was recorded at 10 min intervals for 40 min. Seed pod powder was extracted with different solvents and hydrodistilled seed oil chemical constituents were determined by using Gas chromatography mass spectroscopy (GC-MS) -...
February 23, 2018: International Journal of Environmental Research and Public Health
A Maurya, H N Shivakumar, S Honnavar, M Salwa, S N Murthy
The prevalence of Iron Deficiency Anemia (IDA) is predominant in women and children especially in developing countries. The disorder affects cognitive functions and physical activity. While oral iron supplementation and parenteral therapy remains the preferred choice of treatment, gastric side effects and risk of iron overload decreases adherence to therapy. Transdermal route is an established approach which circumvents the side-effects associated with conventional therapy. In this project, an attempt was made to investigate the use of rapidly dissolving microneedles loaded with Ferric pyrophosphate (FPP) as a potential therapeutic approach for management of IDA...
February 17, 2018: Journal of Pharmaceutical Sciences
Perumal Vivekanandhan, Sengodan Karthi, Muthugounder S Shivakumar, Giovanni Benelli
Mosquito control using chemical insecticides is facing a major challenge due to development of insecticide resistance. Improving the efficiency of existing insecticides using synergistic secondary metabolites of biological origin is increasingly being researched. Herein, we evaluated the toxicity of Fusarium oxysporum extract alone and in binary combinations with temephos, on larvae and pupae of Anopheles stephensi, Aedes aegypti and Culex quinquefaciatus. F. oxysporum extract was characterized using TLC, FT-IR and GC-MS...
February 19, 2018: Pathogens and Global Health
Christopher P Toret, Pruthvi C Shivakumar, Pierre-François Lenne, Andre Le Bivic
Many metazoan developmental processes require cells to transition between migratory mesenchymal- and adherent epithelial-like states. These transitions require Rho GTPase-mediated actin rearrangements downstream of integrin and cadherin pathways. A regulatory toolbox of GEF and GAP proteins precisely coordinates Rho protein activities, yet defining the involvement of specific regulators within a cellular context remains a challenge due to overlapping and coupled activities. Here we demonstrate that Drosophila dorsal closure is a powerful model for Rho GTPase regulation during transitions from leading edges to cadherin contacts...
February 2, 2018: Development
Anmol Ahuja, Om Tantia, Tamonas Chaudhuri, Shashi Khanna, Shivakumar Seetharamaiah, Kajari Majumdar, Ghanshyam Goyal
BACKGROUND: Obesity is one of the major causes for development of T2DM. Metabolic surgery has been proved to be a successful and cost-effective treatment modality for managing the patients with obesity and T2DM. Many scoring systems and models have been described in literature to predict the outcome of T2DM after metabolic surgery. The aim of this study is to compare the efficacy of Diarem, DRS, and ABCD score in predicting the T2DM remission. METHODS: A total number of 102 diabetic patients, who underwent LMGB/LOAGB, were selected for this study...
February 12, 2018: Obesity Surgery
Shivakumar S Jalde, Anil Kumar Chauhan, Ji Hoon Lee, Pankaj Kumar Chaturvedi, Joon-Suk Park, Yong-Wan Kim
Curcumin (cur) has been comprehensively studied for its various biological properties, more precisely for its antitumor potential and it has shown the promising results as well. On the other hand, Chlorin e6 (Ce6) has mostly been used as a photosensitizer in photodynamic therapy (PDT) against a variety of carcinomas. In the present study, we have synthesized a series of Chlorin e6-curcumin (Ce6-cur) conjugates and investigated their photosensitizing potential against pancreatic cancer cell lines. All the synthesized compounds were characterized by UV, 1H NMR, 13C NMR and LC-MS...
February 2, 2018: European Journal of Medicinal Chemistry
Vidya Kadashetti, K M Shivakumar, Minal Chaudhary, Swati Patil, Madhuri Gawande, Alka Hande
Background: Tobacco use can alone lead to death worldwide, especially in developing and underdeveloped countries. China and Brazil are the world's largest producer of tobacco. India holds the third place in producing, and it is the fourth largest consumer of tobacco and its products in the world. Objectives: A case-control study was carried out to assess the influence of risk factors on patients with potentially malignant disorders (PMD) and oral cancer. Materials and Methods: Fifty cases diagnosed with PMD and oral cancer patients were selected for the study...
September 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
Nirupama Shivakumar, Pratibha Dwarkanath, Ronald Bosch, Christopher Duggan, Anura V Kurpad, Tinku Thomas
BACKGROUND/OBJECTIVES: India contributes to one-third of the global burden of low birth weight (LBW) neonates, which is associated with increased risk of mortality and adverse consequences on long-term health. Factors leading to LBW are multidimensional and maternal short stature is an important component with an inter-generational effect. On the contrary gestational weight gain (GWG) shows an independent positive influence on birth weight. The aim of the present study therefore was to determine the influence of GWG on birth weight in short pregnant women...
November 9, 2017: European Journal of Clinical Nutrition
Nick van Es, Martha Louzada, Marc Carrier, Vicky Tagalakis, Peter L Gross, Sudeep Shivakumar, Marc A Rodger, Philip S Wells
BACKGROUND: The risk of recurrent venous thromboembolism (VTE) in cancer patients despite anticoagulant therapy is high. Clinical factors and pro-coagulant markers may identify high-risk patients and guide decisions about intensifying anticoagulation therapy. AIMS: To evaluate whether serial measurements of pro-coagulant markers can identify patients at high risk of recurrent VTE. METHODS: In this multicenter, prospective cohort study, patients with active cancer and acute deep vein thrombosis or pulmonary embolism were enrolled...
January 9, 2018: Thrombosis Research
Zhiying Jiang, Shivakumar Rajamanickam, Nicholas J Justice
Corticotropin-releasing factor (CRF) neurons in the Paraventricular Nucleus of the Hypothalamus (PVN) initiate Hypothalamic-Pituitary-Adrenal (HPA) axis activity through release of CRF into the portal system as part of a coordinated neuroendocrine, autonomic, and behavioral response to stress. Recent discovery of neurons expressing CRF receptor type 1 (CRFR1), the primary receptor for CRF, adjacent to CRF neurons within the PVN, suggest that CRF also signals within the hypothalamus to coordinate aspects of the stress response...
January 19, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Anantharaman Shivakumar, M S Yogendra Kumar
Electrophysiological systems are prone to release free radicals for functioning of biological system with proper balancing of antioxidant-prooxidant ratio for establishing a healthy living system. The biostress condition releases different reactive oxygen species, such as hydroxyl, alkoxyl, superoxide, hydrogen peroxide, hydroperoxyl, ozone, singlet oxygen, hypochlorus acid, thiyl radical, etc. This review tries to discuss the general aspects of the antioxidant assay methodologies that are currently used for the detection of antioxidant property...
January 16, 2018: Critical Reviews in Analytical Chemistry
Chien-Fu Hung, Xuequn Xu, Linhong Li, Ying Ma, Qiu Jin, Angelia Viley, Cornell Allen, Pachai Natarajan, Rama Shivakumar, Madhusudan V Peshwa, Leisha A Emens
CD19-targeted chimeric antigen receptor (CAR) engineered T/natural kill (NK)-cell therapies can result in durable clinical responses in B-cell malignancies. However, CAR-based immunotherapies have been much less successful in solid cancers, in part due to 'on-target off-tumor' toxicity related to expression of target tumor antigens on normal tissue. Based on preliminary observations of safety and clinical activity in proof-of-concept clinical trials, tumor antigen-specific messenger RNA (mRNA) CAR transfection into selected, activated, and expanded T/NK-cells may permit prospective control of 'on-target off-tumor toxicity'...
January 15, 2018: Human Gene Therapy
Dongwook Kim, Manu Shivakumar, Seonggyun Han, Michael S Sinclair, Young-Ji Lee, Yonglan Zheng, Olufunmilayo I Olopade, Dokyoon Kim, Younghee Lee
Regulation of gene expression by DNA methylation in gene promoter regions is well studied; however, the effects of methylation in the gene body (exons and introns) on gene expression are comparatively understudied. Recently, hypermethylation has been implicated in the inclusion of alternatively spliced exons; moreover, exon recognition can be enhanced by recruiting the methyl-CpG-binding protein (MeCP2) to hypermethylated sites. This study examines whether the methylation status of an intron is correlated with how frequently the intron is retained during splicing using DNA methylation and RNA sequencing data from breast cancer tissue specimens in The Cancer Genome Atlas...
January 12, 2018: Molecular Cancer Research: MCR
Herve Tiriac, Juan Carlos Bucobo, Demetrios Tzimas, Suman Grewel, Joseph F Lacomb, Leahana M Rowehl, Satish Nagula, Maoxin Wu, Joseph Kim, Aaron Sasson, Shivakumar Vignesh, Laura Martello, Maria Munoz-Sagastibelza, Jonathan Somma, David A Tuveson, Ellen Li, Jonathan M Buscaglia
BACKGROUND AND AIMS: Pancreatic cancer organoids are tumor models of individualized human pancreatic ductal adenocarcinoma (PDA), created from surgical specimens and used for personalized treatment strategies. Unfortunately the vast majority of patients with PDA are not operative candidates. Creation of human PDA organoids at the time of initial tumor diagnosis is therefore critical. Our aim was to assess the feasibility of creating human PDA organoids by EUS fine-needle biopsy (EUS-FNB) in patients with PDA...
January 8, 2018: Gastrointestinal Endoscopy
M Shivakumar, Leslie Edward Simon Lewis
No abstract text is available yet for this article.
December 15, 2017: Indian Pediatrics
Sunil V Kalmady, Rimjhim Agrawal, Deepthi Venugopal, Venkataram Shivakumar, Anekal C Amaresha, Sri Mahavir Agarwal, Manjula Subbanna, Ashwini Rajasekaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramanian
Earlier studies have implicated CHRNA7, coding α-7 nicotinic acetylcholine receptor (α7 nAChR), and its partially duplicated chimeric gene CHRFAM7A in schizophrenia. However, the relationship between the alterations in peripheral gene expression of CHRFAM7A and severity of clinical symptoms has not been examined. Furthermore, potential influence of the antipsychotic medication on CHRFAM7A expression in drug-naive or drug-free schizophrenia is an unexplored area. CHRFAM7A gene expression in lymphocytes was analyzed in 90 antipsychotic-naïve or free schizophrenia patients using TaqMan-based quantitative RT-PCR...
January 5, 2018: Journal of Neural Transmission
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