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https://www.readbyqxmd.com/read/28735405/profiling-abscisic-acid-induced-changes-in-fatty-acid-composition-in-mosses
#1
Suhas Shinde, Shivakumar Devaiah, Aruna Kilaru
In plants, change in lipid composition is a common response to various abiotic stresses. Lipid constituents of bryophytes are of particular interest as they differ from that of flowering plants. Unlike higher plants, mosses have high content of very long-chain polyunsaturated fatty acids. Such lipids are considered to be important for survival of nonvascular plants. Here, using abscisic acid (ABA )-induced changes in lipid composition in Physcomitrella patens as an example, a protocol for total lipid extraction and quantification by gas chromatography (GC) coupled with flame ionization detector (FID) is described...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28725021/bovine-milk-derived-exosomes-from-colostrum-are-enriched-with-proteins-implicated-in-immune-response-and-growth
#2
Monisha Samuel, David Chisanga, Michael Liem, Shivakumar Keerthikumar, Sushma Anand, Ching-Seng Ang, Christopher G Adda, Ellen Versteegen, Markandeya Jois, Suresh Mathivanan
Exosomes are extracellular vesicles secreted by multiple cell types into the extracellular space. They contain cell-state specific cargos which often reflects the (patho)physiological condition of the cells/organism. Milk contains high amounts of exosomes and it is unclear whether their cargo is altered based on the lactation stage of the organism. Here, we isolated exosomes from bovine milk that were obtained at various stages of lactation and examined the content by quantitative proteomics. Exosomes were isolated by OptiPrep density gradient centrifugation from milk obtained from cow after 24, 48 and 72 h post calving...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28723280/case-248
#3
Aruna R Patil, Shrivalli Nandikoor, Govindarajan Mallarajapatna, Swarna Shivakumar
No abstract text is available yet for this article.
August 2017: Radiology
https://www.readbyqxmd.com/read/28722356/hansen-solubility-parameters-for-assay-method-optimization-of-simvastatin-ramipril-atenolol-hydrochlorothiazide-and-aspirin-in-human-plasma-using-liquid-chromatography-with-tandem-mass-spectrometry
#4
Murali Mohan Reddy Devalapalli, Hanumanth Srikanth Cheruvu, Thejaswi Yertha, Vijaya Bhaskar Veeravalli, Sunitha Sampathi, Savithri Shivakumar
A simple, specific, sensitive validated method was developed using liquid chromatography with tandem mass spectrometry with electrospray ionization of human plasma for the simultaneous estimation of drugs (simvastatin, ramipril, atenolol, hydrochlorothiazide and aspirin) of Polycap(TM) capsule used in cardiovascular therapy. The interaction of these actives including internal standards between the stationary and mobile phase were investigated using Hansen solubility parameters. Chromatographic separation was performed on Phenomenex Synergi Polar-RP (30 × 2 mm, 4 μm) column with a gradient mobile phase composition of acetonitrile and 5 mM ammonium formate for positive mode and 0...
July 19, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28717418/a-novel-community-driven-software-for-functional-enrichment-analysis-of-extracellular-vesicles-data
#5
Mohashin Pathan, Shivakumar Keerthikumar, David Chisanga, Riccardo Alessandro, Ching-Seng Ang, Philip Askenase, Arsen O Batagov, Alberto Benito-Martin, Giovanni Camussi, Aled Clayton, Federica Collino, Dolores Di Vizio, Juan Manuel Falcon-Perez, Pedro Fonseca, Pamali Fonseka, Simona Fontana, Yong Song Gho, An Hendrix, Esther Nolte-'t Hoen, Nunzio Iraci, Kenneth Kastaniegaard, Thomas Kislinger, Joanna Kowal, Igor V Kurochkin, Tommaso Leonardi, Yaxuan Liang, Alicia Llorente, Taral R Lunavat, Sayantan Maji, Francesca Monteleone, Anders Øverbye, Theocharis Panaretakis, Tushar Patel, Héctor Peinado, Stefano Pluchino, Simona Principe, Goran Ronquist, Felix Royo, Susmita Sahoo, Cristiana Spinelli, Allan Stensballe, Clotilde Théry, Martijn J C van Herwijnen, Marca Wauben, Joanne L Welton, Kening Zhao, Suresh Mathivanan
Bioinformatics tools are imperative for the in depth analysis of heterogeneous high-throughput data. Most of the software tools are developed by specific laboratories or groups or companies wherein they are designed to perform the required analysis for the group. However, such software tools may fail to capture "what the community needs in a tool". Here, we describe a novel community-driven approach to build a comprehensive functional enrichment analysis tool. Using the existing FunRich tool as a template, we invited researchers to request additional features and/or changes...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28680172/direct-oral-anticoagulants-and-vitamin-k-antagonists-for-treatment-of-deep-venous-thrombosis-and-pulmonary-embolism-in-the-outpatient-setting-comparative-economic-evaluation
#6
Abdullah S Al Saleh, Patrick Berrigan, David Anderson, Sudeep Shivakumar
BACKGROUND: To date, there have been few economic evaluations, from a Canadian perspective, of direct oral anticoagulants (DOACs) for the prevention of recurrent venous thromboembolism (VTE) in patients with acute unprovoked VTE. As a result, there is a lack of consensus about which treatment strategy should be adopted in the clinical setting. OBJECTIVES: To assess the cost-effectiveness of currently approved anti-coagulant options, in terms of cost per quality-adjusted life-year (QALY) gained, for the prevention of recurrent VTE in patients with unprovoked events managed on an outpatient basis...
May 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28665015/autotransporter-adhesins-in-escherichia-coli-pathogenesis
#7
REVIEW
Julieanne L Vo, Gabriela Constanza Martínez Ortiz, Pramod Subedi, Shivakumar Keerthikumar, Suresh Mathivanan, Jason J Paxman, Begoña Heras
Most bacteria produce adhesion molecules to facilitate the interaction with host cells and establish successful infections. An important group of bacterial adhesins belong to the autotransporter (AT) superfamily, the largest group of secreted and outer membrane proteins in Gram-negative bacteria. AT adhesins possess diverse functions that facilitate bacterial colonisation, survival and persistence, and as such are often associated with increased bacterial fitness and pathogenic potential. In this review, we will describe AIDA-I type AT adhesins, which comprise the biggest and most diverse group in the AT family...
June 30, 2017: Proteomics
https://www.readbyqxmd.com/read/28663672/gastric-varices-in-cirrhosis-vs-extrahepatic-portal-venous-obstruction-and-response-to-endoscopic-n-butyl-2-cyanoacrylate-injection
#8
Barjesh C Sharma, Shivakumar Varakanahalli, Jatinder P Singh, Siddharth Srivastava
BACKGROUND: Gastric varices (GV) are found in patients with portal hypertension. Incidence of bleeding from GV is relatively low, but is severe, and associated with higher mortality. AIMS AND OBJECTIVES: To compare the types of GV in cirrhosis vs. extrahepatic portal venous obstruction (EHPVO) and the results of endoscopic N-butyl-2-cyanoacrylate (NBC, glue) injection. METHODS: Four hundred and fifty-four patients undergone glue injection of GV for primary prophylaxis or control of bleeding for first episode of bleeding from GV between August 2010 and August 2015 were analyzed...
June 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28661012/mixed-stack-charge-transfer-crystals-of-pillar-5-quinone-and-tetrathiafulvalene-exhibiting-ferroelectric-features
#9
Kilingaru Ishwara Shivakumar, K Swathi, Goudappagouda Patil, Tamal Das, Ashwani Kumar, Ravindra Makde, Kumar Vanka, Sukumaran Santhosh Babu, K S Narayan, Gangadhar J Sanjayan
Ferroelectric materials find extensive applications in the fabrication of compact memory devices and ultra-sensitive multifunctional detectors. Face-to-face alternate stacking of electron donors and acceptors effectuate long-range unidirectional ordering of charge transfer (CT) dipoles, promising tunable ferroelectricity. Herein we report a new TTF-quinone system - an emerald green CT complex consisting pillar[5]quinone (P5Q) and tetrathiafulvalene (TTF). The CT crystals, as determined by single crystal synchrotron X-ray diffraction, adopt a 1:1 mixed-stack arrangement of donor and acceptor with alternating dimers of TTF and 1,4-dioxane encapsulated P5Q...
June 29, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28640628/oriented-gold-nanorods-and-gold-nanorod-chains-within-smectic-liquid-crystal-topological-defects
#10
Brigita Rožič, Jérôme Fresnais, Celine Molinaro, Joseph Calixte, Shivakumar Umadevi, Stephanie Lau-Truong, Nordin Felidj, Tobias Kraus, Fabrice Charra, Vincent Dupuis, Torsten Hegmann, Celine Fiorini-Debuisschert, Bruno Gallas, Emmanuelle Lacaze
We show that the use of oriented linear arrays of smectic A defects, the so-called smectic oily streaks, enables the orientation of gold nanorods (GNRs) for a large range of GNR diameters, ranging from 7 to 48 nm, and for various ligands. For the small GNRs it enables oriented end-to-end small chains of GNRs when the density is increased from around 2 GNRs/μm(2) to around 6 GNRs/μm(2). We have characterized the orientation of single GNRs by spectrophotometry and two-photon luminescence (TPL). A strongly anisotropic absorption of the composites and an on-off switching of GNR luminescence, both controlled by incident light polarization, are observed, revealing an orientation of the GNRs mostly parallel to the oily streaks...
June 22, 2017: ACS Nano
https://www.readbyqxmd.com/read/28618177/assessing-the-quality-of-primary-care-referrals-to-surgery-of-patients-with-diabetes-in-the-east-of-england-a-multi-centre-cross-sectional-cohort-study
#11
Dimitri J Pournaras, Evangelos S Photi, Nicholas Barnett, Christopher P Challand, Nikolaos A Chatzizacharias, Nokwanda P Dlamini, Triantafyllos Doulias, Aoibhinn Foley, James Hernon, Bhaskar Kumar, Jack Martin, Ian Nunney, Ioanna Panagiotopoulou, Neel Sengupta, Oshini Shivakumar, Piriyah Sinclair, Phil Stather, Miriam M Than, Antonia C Wells, Athanasios Xanthis, Ketan Dhatariya
AIM: Peri-operative hyperglycaemia is associated with an increased incidence of adverse outcomes. Communication between primary and secondary care is paramount to minimise these harms. National guidance in the UK recommends that the glycated haemoglobin (HbA1c) should be measured within 3 months prior to surgery and that the concentration should be less that 69 mmol/mol (8.5%). In addition, national guidance outlines the minimum dataset that should be included in any letter at the time of referral to the surgeons...
June 15, 2017: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/28615756/neurocognitive-impairments-in-unaffected-first-degree-relatives-of-schizophrenia
#12
Virupaksha Shanmugam Harave, Venkataram Shivakumar, Sunil V Kalmady, Janardhanan C Narayanaswamy, Shivarama Varambally, Ganesan Venkatasubramanian
BACKGROUND: Neurocognitive impairments of attention and executive functioning are trait abnormalities in schizophrenia, and these are considered to be endophenotypes. These deficits have been convincingly linked to prefrontal cortical functioning. In this study, we examined the cognitive performance in the domains of attention and executive functioning among first-degree relatives of Indian people with schizophrenia (high-risk [HR] patients) compared to healthy controls (HC). MATERIALS AND METHODS: Siblings of patients with DSM-IV schizophrenia, HR patients (n = 17), were compared with HC (n = 30) (matched as a group for age, sex, years of education, and handedness) using the following neurocognitive tests for attention and executive function - digit span test (DST), trail making test, letter-number sequencing (LNS), and spatial span test...
May 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28608560/endocannabinoid-system-in-neurodegenerative-disorders
#13
REVIEW
Balapal S Basavarajappa, Madhu Shivakumar, Vikram Joshi, Shivakumar Subbanna
Most neurodegenerative disorders (NDDs) are characterized by cognitive impairment and other neurological defects. The definite cause of and pathways underlying the progression of these NDDs are not well-defined. Several mechanisms have been proposed to contribute to the development of NDDs. These mechanisms may proceed concurrently or successively, and they differ among cell types at different developmental stages in distinct brain regions. The endocannabinoid system, which involves cannabinoid receptors type 1 (CB1R) and type 2 (CB2R), endogenous cannabinoids and the enzymes that catabolize these compounds, has been shown to contribute to the development of NDDs in several animal models and human studies...
June 13, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28602428/influence-of-amalaki-rasayana-on-telomerase-activity-and-telomere-length-in-human-blood-mononuclear-cells
#14
Kanive P Guruprasad, Sweta Dash, Marigowda B Shivakumar, Pavithra R Shetty, Kothanahalli S Raghu, Bhanuvalli R Shamprasad, Vishwanatha Udupi, Raviraj V Acharya, Prasanna B Vidya, Jayakrishna Nayak, Anandan E Mana, Rajesh Moni, Muraleedharan T Sankaran, Kapaettu Satyamoorthy
BACKGROUND: Indian traditional medicine practices use defined rasayana preparations to improve the quality of life in aged individuals. Amalaki Rasayana is one such rasayana prepared from the fruits of Phyllanthus emblica and is popularly used to prevent or treat various age related health conditions. Telomerase activity in the cells maintains telomere length and is implicated in ageing and various diseases wherein the shortening of telomere during ageing is controlled chiefly by the telomerase activity...
April 2017: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/28600140/income-generated-by-women-treated-with-magnetic-resonance-imaging-based-brachytherapy-a-simulation-study-evaluating-the-macroeconomic-benefits-of-implementing-a-high-end-technology-in-a-public-sector-healthcare-setting
#15
Santam Chakraborty, Umesh Mahantshetty, Supriya Chopra, Shirley Lewis, Vinod Hande, Shivakumar Gudi, Rahul Krishnatry, Reena Engineer, Shyam Kishore Shrivastava
PURPOSE: To estimate the difference in income generated if all women presenting in our institute over a 5-year period were treated with MRI-based image-guided brachytherapy (MR-IGBT) instead of conventional radiograph-based brachytherapy (CR-BT). METHODS AND MATERIALS: Outcome data from 463 patients (94 treated with MR-IGBT) treated in our institute was used to simulate cumulative women-days of work and cumulative income over 5 years for 5526 patients expected to be treated in this period...
June 6, 2017: Brachytherapy
https://www.readbyqxmd.com/read/28596037/development-and-evaluation-of-an-oral-fast-disintegrating-anti-allergic-film-using-hot-melt-extrusion-technology
#16
Manjeet B Pimparade, Anh Vo, Abhijeet S Maurya, Jungeun Bae, Joseph T Morott, Xin Feng, Dong Wuk Kim, Vijay I Kulkarni, Roshan Tiwari, K Vanaja, Reena Murthy, H N Shivakumar, D Neupane, S R Mishra, S N Murthy, Michael A Repka
The main objective of this novel study was to develop chlorpheniramine maleate orally disintegrating films (ODF) using hot-melt extrusion technology and evaluate the characteristics of the formulation using in vitro and in vivo methods. Modified starch with glycerol was used as a polymer matrix for melt extrusion. Sweetening and saliva-simulating agents were incorporated to improve palatability and lower the disintegration time of film formulations. A standard screw configuration was applied, and the last zone of the barrel was opened to discharge water vapors, which helped to manufacture non-sticky, clear, and uniform films...
June 5, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28589857/identification-of-epigenetic-interactions-between-mirna-and-dna-methylation-associated-with-gene-expression-as-potential-prognostic-markers-in-bladder-cancer
#17
Manu Shivakumar, Younghee Lee, Lisa Bang, Tullika Garg, Kyung-Ah Sohn, Dokyoon Kim
BACKGROUND: One of the fundamental challenges in cancer is to detect the regulators of gene expression changes during cancer progression. Through transcriptional silencing of critical cancer-related genes, epigenetic change such as DNA methylation plays a crucial role in cancer. In addition, miRNA, another major component of epigenome, is also a regulator at the post-transcriptional levels that modulate transcriptome changes. However, a mechanistic role of synergistic interactions between DNA methylation and miRNA as epigenetic regulators on transcriptomic changes and its association with clinical outcomes such as survival have remained largely unexplored in cancer...
May 24, 2017: BMC Medical Genomics
https://www.readbyqxmd.com/read/28567148/hip-abductor-strengthening-improves-physical-function-following-total-knee-replacement-one-year-follow-up-of-a-randomized-pilot-study
#18
Karvannan Harikesavan, Raj D Chakravarty, Arun G Maiya, Sanjay P Hegde, Shivakumar Y Shivanna
BACKGROUND: Total knee replacement (TKR) is the commonest surgical procedure for patients with severe pain and impaired physical function following end stage knee osteoarthritis. The hip abductors are well renowned in stabilization of the trunk and hip during walking, maintaining the lower limb position, and transferring the forces from the lower limbs to the pelvis. OBJECTIVE: To assess the efficacy of hip abductor strengthening exercise on functional outcome using performance based outcome measures following total knee replacement...
2017: Open Rheumatology Journal
https://www.readbyqxmd.com/read/28558892/functional-near-infra-red-spectroscopy-fnirs-in-schizophrenia-a-review
#19
REVIEW
Vijay Kumar, Venkataram Shivakumar, Harleen Chhabra, Anushree Bose, Ganesan Venkatasubramanian, Bangalore N Gangadhar
The research on the alterations in functional connectivity in schizophrenia has been facilitated by development of an array of functional neuroimaging techniques. Functional Near Infra Red Spectroscopy (fNIRS) is a novel diffuse optical neuromonitring method with its own advantages and limitations. The advantages of fNIRS have made it to be frequently used as a research tool by medical community in different settings. In fNIRS the property of haemoglobin to absorb near infrared light is used to measure brain activity...
June 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28557150/characterization-of-cd34-deficient-myofibroblastomas-of-the-breast
#20
Timothy M D'Alfonso, Shivakumar Subramaniyam, Paula S Ginter, Juan Miguel Mosquera, Jaclyn Croyle, Yi-Fang Liu, Mark A Rubin, Sandra J Shin
Mammary myofibroblastoma is a benign spindle cell tumor that can show variable morphologic patterns and lines of differentiation. Diffuse and strong immunohistochemical expression of CD34 is a characteristic of myofibroblastoma and greatly aids in confirming a diagnosis. Myofibroblastoma has been shown to belong to a family of CD34-positive tumors with similar morphology that show a deletion of 13q14, which includes RB1 and FOXO1A genes. The purpose of this study was to better understand a subset of myofibroblastomas that is characteristically CD34-deficient by immunohistochemistry...
May 30, 2017: Breast Journal
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