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https://www.readbyqxmd.com/read/28440914/transesophageal-bronchoscopic-ultrasound-guided-fine-needle-aspiration-eus-b-fna-pushing-the-boundaries-in-the-diagnosis
#1
Ravindra Mehta, Pavan Biraris, Swarna Shivakumar, Seema Misra, Parameswaran Anoop, Srikanta J T
Isolated mediastinal adenopathy is a diagnostic challenge in the paediatric population, often requiring invasive surgical procedures for diagnosis. We describe a novel minimally invasive modality in a 20 month toddler-transesophageal bronchoscopic ultrasound-guided fine-needle aspiration (EUS-B-FNA). This is the youngest reported use of this modality, highlighting feasibility, technical issues, safety, and rapid diagnosis leading to expedited treatment.
April 25, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28413277/efficacy-of-dexmedetomidine-with-ropivacaine-in-supraclavicular-brachial-plexus-block-for-upper-limb-surgeries
#2
Jithendra Chinnappa, Shivakumar Shivanna, Vinayak Seenappa Pujari, Tejesh Channasandra Anandaswamy
BACKGROUND AND AIMS: The primary aim of this study was to evaluate the effect of addition of dexmedetomidine on the duration of analgesia in patients undergoing upper limb surgeries under supraclavicular brachial plexus block. MATERIAL AND METHODS: Sixty patients of American Society of Anesthesiologists physical status I/II/III undergoing elective upper limb surgeries under supraclavicular brachial plexus block using nerve stimulator were randomized into two groups...
January 2017: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/28389269/estimation-of-reproduction-number-and-non-stationary-spectral-analysis-of-dengue-epidemic
#3
Murali Krishna Enduri, Shivakumar Jolad
In this work we analyze the post monsoon Dengue outbreaks by analyzing the transient and long term dynamics of Dengue incidences and its environmental correlates in Ahmedabad city in western India from 2005 to 2012. We calculate the reproduction number Rp using the growth rate of post monsoon Dengue outbreaks and biological parameters like host and vector incubation periods and vector mortality rate, and its uncertainties are estimated through Monte-Carlo simulations by sampling parameters from their respective probability distributions...
April 5, 2017: Mathematical Biosciences
https://www.readbyqxmd.com/read/28371658/clinical-correlates-of-hippocampus-volume-and-shape-in-antipsychotic-na%C3%A3-ve-schizophrenia
#4
Sunil Vasu Kalmady, Venkataram Shivakumar, Rashmi Arasappa, Aditi Subramaniam, S Gautham, Ganesan Venkatasubramanian, Bangalore N Gangadhar
While volume deficit of hippocampus is an established finding in schizophrenia, very few studies have examined large sample of patients without the confounding effect of antipsychotic treatment. Concurrent evaluation of hippocampus shape will offer additional information on the hippocampal aberrations in schizophrenia. In this study, we analyzed the volume and shape of hippocampus in antipsychotic-naïve schizophrenia patients (N=71) in comparison to healthy controls (N=82). Using 3-T MRI data, gray matter (GM) volume (anterior and posterior sub-divisions) and shape of the hippocampus were analyzed...
March 29, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28349179/current-challenges-in-the-management-of-sepsis-in-icus-in-resource-poor-settings-and-suggestions-for-the-future
#5
REVIEW
Marcus J Schultz, Martin W Dunser, Arjen M Dondorp, Neill K J Adhikari, Shivakumar Iyer, Arthur Kwizera, Yoel Lubell, Alfred Papali, Luigi Pisani, Beth D Riviello, Derek C Angus, Luciano C Azevedo, Tim Baker, Janet V Diaz, Emir Festic, Rashan Haniffa, Randeep Jawa, Shevin T Jacob, Niranjan Kissoon, Rakesh Lodha, Ignacio Martin-Loeches, Ganbold Lundeg, David Misango, Mervyn Mer, Sanjib Mohanty, Srinivas Murthy, Ndidiamaka Musa, Jane Nakibuuka, Ary Serpa Neto, Mai Nguyen Thi Hoang, Binh Nguyen Thien, Rajyabardhan Pattnaik, Jason Phua, Jacobus Preller, Pedro Povoa, Suchitra Ranjit, Daniel Talmor, Jonarthan Thevanayagam, C Louise Thwaites
BACKGROUND: Sepsis is a major reason for intensive care unit (ICU) admission, also in resource-poor settings. ICUs in low- and middle-income countries (LMICs) face many challenges that could affect patient outcome. AIM: To describe differences between resource-poor and resource-rich settings regarding the epidemiology, pathophysiology, economics and research aspects of sepsis. We restricted this manuscript to the ICU setting even knowing that many sepsis patients in LMICs are treated outside an ICU...
March 27, 2017: Intensive Care Medicine
https://www.readbyqxmd.com/read/28345184/spatial-molecular-epidemiology-of-carbapenem-resistant-and-new-delhi-metallo-beta-lactamase-blandm-producing-escherichia-coli-strains-from-farmed-piglets-of-india
#6
B S Pruthvishree, O R Vinodh Kumar, D K Sinha, Y P S Malik, Z Dubal, P A Desingu, M Shivakumar, Narayanan Krishnaswamy, B R Singh
AIM: A cross-sectional study was conducted in ten government organized pig farms between 2014 and 2016 representing seven states of India to understand the epidemiology of carbapenem resistance in Escherichia coli isolates. METHODS AND RESULTS: In this study, 673 fecal samples both from non- diarhhoeic (n=501) and diarrhoeic (n=172) piglets were processed for isolation of carbapenem resistant E. coli. Wherein, 112 confirmed E. coli isolates were further subjected for genotypic confirmation of carbapenem resistance and virulence factors...
March 27, 2017: Journal of Applied Microbiology
https://www.readbyqxmd.com/read/28330188/purification-and-characterization-of-a-surfactant-compatible-lipase-from-aspergillus-tamarii-jgif06-exhibiting-energy-efficient-removal-of-oil-stains-from-polycotton-fabric
#7
Arijit Das, Srividya Shivakumar, Sourav Bhattacharya, Sujina Shakya, S S Swathi
An extracellular lipase with 23,666.66 U/ml/min activity was produced by Aspergillus tamarii JGIF06 under submerged fermentation in mineral salt medium containing coconut oil (2.5 % v/v), tryptone (2 % w/v) and ammonium chloride (2 % w/v), with initial pH of 5 ± 0.2, incubated at 25 °C for 7 days on a rotary shaker at 120 rpm. A 7.9-fold increase in lipase-specific activity was recorded after purification by DEAE Sepharose ion exchange and Sephadex G200 column chromatography. The apparent molecular mass of this enzyme was revealed as 50 kDa by sodium dodecyl sulphate polyacrylamide gel electrophoresis...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28325242/radiation-oncology-in-india-challenges-and-opportunities
#8
REVIEW
Surbhi Grover, Shivakumar Gudi, Ajeet Kumar Gandhi, Priya M Puri, Adam C Olson, Danielle Rodin, Onyi Balogun, Preet K Dhillon, Daya Nand Sharma, Goura Kishor Rath, Shyam Kishore Shrivastava, Akila N Viswanathan, Umesh Mahantshetty
Rising cancer incidence and mortality in India emphasize the need to address the increasing burden of this disease and the stark inequities in access to radiotherapy and other essential medical treatments. State-of-the-art technology is available within the private sector and a few hospitals in the public sector, but 75% of patients in the public sector in India do not have access to timely radiotherapy. This inequity in access to radiotherapy in the public sector is amplified in rural areas, where most of India׳s population lives...
April 2017: Seminars in Radiation Oncology
https://www.readbyqxmd.com/read/28298833/minimally-invasive-maxillary-sinus-elevation-using-balloon-system-a-case-series
#9
Radha Bharathi Dhandapani, Shivakumar Baskaran, Kurumathur Vasudevan Arun, Thirunelveli Saravanan Subbu Kumar
The posterior maxillary segment frequently exhibits insufficient bone mass to support dental implants. Sinus floor augmentation enables implant placement in the posterior maxilla. This case series included ten sites, in which sinus floor elevation was done using sinus lift balloon system followed by augmentation utilizing irradiated cancellous bone allograft. Postoperative radiographic assessment of vertical bone gain was done at 3 and 6 months follow-up period. The mean initial and final bone height were 6...
July 2016: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/28289970/trans-ungual-delivery-of-ar-12-a-novel-antifungal-drug
#10
Avadhesh Singh Kushwaha, P Sharma, H N Shivakumar, C Rappleye, A Zukiwski, S Proniuk, S Narasimha Murthy
AR-12 is a novel small molecule with broad spectrum antifungal activity. Recently, AR-12 was found to be highly active against Trichophyton rubrum, one of the predominantly responsible organisms that cause onychomycosis. The primary objective of this project was to investigate the ability of AR-12 to penetrate into and across the human nail plate followed by improving its trans-ungual permeation using different penetration enhancers. TranScreen-N™, a high throughput screening method was utilized to explore the potential nail penetration enhancers to facilitate the drug delivery through the nail...
March 13, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28289704/preferential-tnf%C3%AE-signaling-via-tnfr2-regulates-epithelial-injury-and-duct-obstruction-in-experimental-biliary-atresia
#11
Pranavkumar Shivakumar, Tatsuki Mizuochi, Reena Mourya, Sridevi Gutta, Li Yang, Zhenhua Luo, Jorge A Bezerra
Biliary atresia is an obstructive cholangiopathy of infancy that progresses to end-stage cirrhosis. Although the pathogenesis of the disease is not completely understood, previous reports link TNFα to apoptosis of the bile duct epithelium in the presence of IFNγ. Here, we investigate if TNFα signaling regulates pathogenic mechanisms of biliary atresia. First, we quantified the expression of TNFA and its receptors TNFR1 and TNFR2 in human livers and found an increased expression of the receptors at the time of diagnosis...
March 9, 2017: JCI Insight
https://www.readbyqxmd.com/read/28283227/clozapine-as-the-most-efficacious-antipsychotic-for-activating-erk-1-2-kinases-role-of-5-ht2a-receptor-agonism
#12
Stefano Aringhieri, Shivakumar Kolachalam, Claudio Gerace, Marco Carli, Valeria Verdesca, Maria Giulia Brunacci, Chiara Rossi, Chiara Ippolito, Anna Solini, Giovanni U Corsini, Marco Scarselli
Antipsychotics (APDs) are divided into first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) based on the concept that SGAs have reduced motor side effects. With this premise, this study examined in HeLa and other cell lines the effects of different APDs on the activation of ERK1/2 (Extracellular signal-regulated kinases) and AKT (Protein Kinase B) kinases, which may be affected in schizophrenia and bipolar disorder. Among the SGAs, Clozapine clearly resulted as the most effective drug inducing ERK1/2 phosphorylation with potency in the low micromolar range...
March 7, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28278318/association-of-pseudoexfoliation-with-systemic-vascular-diseases-in-a-south-indian-population
#13
COMPARATIVE STUDY
Ashok Vardhan S, Aravind Haripriya, Banushree Ratukondla, Pradeep Ramulu, Chandrasekaran Shivakumar, Manas Nath, Prabhu Vijayaraghavan, Alan L Robin
Importance: Ocular pseudoexfoliation (PEX) syndrome may be associated with systemic vascular diseases, which might suggest a broader health significance of PEX, although previous reports are conflicting. Objective: To determine whether prespecified vascular risk factors and cardiac abnormalities are more common among patients with PEX than among control individuals without PEX. Design, Setting, and Participants: This cross-sectional analysis of patients recruited into the Aravind Pseudoexfoliation study included South Indian patients older than 40 years with or without PEX who required cataract surgery...
April 1, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28275009/paracrine-signals-regulate-human-liver-organoid-maturation-from-induced-pluripotent-stem-cells
#14
Akihiro Asai, Eitaro Aihara, Carey Watson, Reena Mourya, Tatsuki Mizuochi, Pranavkumar Shivakumar, Kieran Phelan, Christopher Mayhew, Michael Helmrath, Takanori Takebe, James Wells, Jorge A Bezerra
A self-organizing organoid model provides a new approach to study the mechanism of human liver organogenesis. Previous animal models documented that simultaneous paracrine signaling and cell-to-cell surface contact regulate hepatocyte differentiation. To dissect the relative contributions of the paracrine effects, we first established a liver organoid using human induced pluripotent stem cells (iPSCs), mesenchymal stem cells (MSCs) and human umbilical vein endothelial cells (HUVECs) as previously reported. Time-lapse imaging showed that hepatic-specified endoderm iPSCs (HE-iPSCs) self-assembled into three-dimensional organoids, resulting in hepatic gene induction...
March 15, 2017: Development
https://www.readbyqxmd.com/read/28273985/giant-antrochoanal-polyp-a-rare-presentation
#15
Swati Kodur, Shruti Malavalli Siddappa, Andanooru Mahalingappa Shivakumar
Antrochoanal polyp (ACP), also called as Killian polyp, is an infrequent, benign lesion of maxillary origin in non-atopic patients. The antrochoanal polyp is shaped according to the anatomical constraints of the lateral nasal wall, particularly the middle meatus and antrum, resembling typically a dumbbell. Here presenting a common problem with unusual presentation.
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28266094/controlled-growth-of-gold-nanostars-effect-of-spike-length-on-sers-signal-enhancement
#16
S V Sheen Mers, S Umadevi, V Ganesh
Two different types of gold nanostars (Au NS), namely, short-spiked nanostars (SSNS) and long-spiked nanostars (LSNS), are prepared by using a hexagonal lyotropic liquid-crystalline (LLC) phase as a template. The formation, size and length of spikes or arms of the resultant Au NS are controlled by preparation in either a hexagonal LLC phase or an isotropic phase. These NS are anchored onto indium tin oxide (ITO) electrodes through a self-assembled monolayer of 3-mercaptopropyltrimethoxysilane, which acts as a linker molecule...
March 7, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28262134/interventions-in-adhd-a-comparative-review-of-stimulant-medications-and-behavioral-therapies
#17
REVIEW
Adnan Rajeh, Shabbir Amanullah, K Shivakumar, Julie Cole
ADHD has a prevalence of approximately 10% in children with evidence supporting it's continuance into adulthood. This has a significant impact on how we address treatment at substance abuse facilities and also has implications for personal and occupational functioning. A lack of evidence to support the superiority of any one intervention over the other has created difficulties for both clinicians and parents. A recent review highlights long-term and short-term outcomes (Craig et al., 2015). This article reviews the benefits and pitfalls of both pharmacological interventions and behavioral therapies in the treatment of ADHD...
February 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28256460/international-open-trial-of-uniform-multidrug-therapy-regimen-for-leprosy-patients-findings-implications-for-national-leprosy-programmes
#18
Ponnaiah Manickam, Sanjay M Mehendale, Bathyala Nagaraju, Kiran Katoch, Abdul Jamesh, Ramalingam Kutaiyan, Shen Jianping, Shivakumar Mugudalabetta, Vitthal Jadhav, Prabu Rajkumar, Jayasree Padma, Kanagasabai Kaliaperumal, Vijayakumar Pannikar, Padabettu Krishnamurthy, Mohan D Gupte
BACKGROUND & OBJECTIVES: Uniform therapy for all leprosy patients will simplify leprosy treatment. In this context, we evaluated six-month multidrug therapy (MDT) currently recommended for multibacillary (MB) patients as uniform MDT (U-MDT) in a single-arm open trial under programme conditions. Primary objective was to determine efficacy to prevent five-year cumulative five per cent relapse. Secondary objectives were to assess acceptability, safety and compliance. METHODS: Newly detected, treatment-naive leprosy patients were enrolled in India (six sites) and P...
October 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28250567/feasibility-of-online-neuromodulation-using-transcranial-alternating-current-stimulation-in-schizophrenia
#19
Vanteemar S Sreeraj, Vandita Shanbhag, Hema Nawani, Venkataram Shivakumar, Dinakaran Damodharan, Anushree Bose, Janardhanan C Narayanaswamy, Ganesan Venkatasubramanian
Abnormalities in resting and event-related brain oscillations are known to be associated with cognitive deficits in schizophrenia. Transcranial alternating current stimulation (tACS) modulates these rhythms across the neuronal circuits and could have a potential therapeutic role in psychiatric disorders. In this report, we describe, for the first time, application of online tACS in a schizophrenia patient with working memory deficits. This case report supports the feasibility and potential utility of online tACS in schizophrenia, which needs further systematic research...
January 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28250483/intravenous-palonosetron-compared-with-a-combination-of-ramosetron-and-dexamethasone-in-preventing-post-operative-nausea-and-vomiting-in-patients-undergoing-gynaecological-surgeries-under-spinal-anaesthesia-a-randomised-study
#20
Archana B Narayanappa, Shivakumar Gurulingaswamy, Umesh N Prabhakaraiah, Somsundar R Gurushanth, Vinay Sapare, Nagaraj Goud
BACKGROUND AND AIMS: Post-operative nausea and vomiting (PONV) is one of the most common complications in patients undergoing gynaecological surgeries under spinal anaesthesia (SA). Palonosetron has the unique property of controlling 'delayed chemotherapy-induced nausea and vomiting' when compared to older serotonin antagonists. This study compared the effectiveness of palonosetron with a combination of ramosetron and dexamethasone in preventing PONV. METHODS: Sixty patients undergoing gynaecological surgeries under SA were randomly allocated into two groups of thirty each, to receive either a combination of 0...
February 2017: Indian Journal of Anaesthesia
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