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https://www.readbyqxmd.com/read/28934620/clinical-utility-and-tolerability-of-transcranial-direct-current-stimulation-in-mild-cognitive-impairment
#1
Venkatachalam Murugaraja, V Shivakumar, Palanimuthu T Sivakumar, Preeti Sinha, Ganesan Venkatasubramanian
BACKGROUND: Neuromodulatory interventions like transcranial direct current stimulation (tDCS) is emerging as a potential therapeutic strategy to promote cognitive function in healthy and pathological aging. There is need for more studies evaluating the utility and tolerability of tDCS in Mild cognitive impairment (MCI). Since MCI is considered as the prodromal stage of dementia, it has emerged as the most important target for intervention in dementia. OBJECTIVE AND METHOD: This study investigated the feasibility, tolerability and clinical utility of tDCS in patients with MCI...
September 8, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28886429/pre-treatment-with-melatonin-decreases-abamectin-induced-toxicity-in-a-nocturnal-insect-spodoptera-litura-lepidoptera-noctuidae
#2
Subramanian P Subala, Eduardo E Zubero, Moises A Alatorre-Jimenez, Muthugounder S Shivakumar
AIM: Oxidative stress is an important component of the mechanism of pesticide toxicity. The aim of the present study was to investigate the time-dependent melatonin effects against abamectin-induced oxidative stress in a S.litura model. Larvae were divided into 5 different groups; (1) control group,(2) Melatonin group (4.3×10(-5)M/100ml diet), (3) Abamectin group 1.5ml/L, (4) Pre-melatonin treated group (PM) (4.3×10(-5)M/100ml diet) before abamectin exposure 1.5ml/L, (5) Post-melatonin treated group (TM) after abamectin exposure...
September 1, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/28884475/chronic-exposure-of-interleukin-13-suppress-the-induction-of-matrix-metalloproteinase-1-by-tumor-necrosis-factor-%C3%AE-in-normal-and-scleroderma-dermal-fibroblasts-through-protein-kinase-b-akt
#3
Monica L Brown Lobbins, Bangalore R Shivakumar, Arnold E Postlethwaite, Karen A Hasty
OBJECTIVE: Peripheral blood mononuclear cells taken from patients with scleroderma express increased levels of IL-13. Moreover, the expression of MMP-1 from involved scleroderma skin fibroblasts is refractory to stimulation by tumor necrosis factor alpha. To elucidate the mechanism(s) involved, we examined the effect of IL-13 on TNF-α-induced matrix metalloproteinase-1 expression in normal and scleroderma human dermal fibroblast lines and studied the involvement of serine/threonine kinase B/Akt in this response...
September 7, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28866447/efficacy-of-fronto-temporal-transcranial-direct-current-stimulation-for-refractory-auditory-verbal-hallucinations-in-schizophrenia-a-randomized-double-blind-sham-controlled-study
#4
Anushree Bose, Venkataram Shivakumar, Sri Mahavir Agarwal, Sunil V Kalmady, Sonia Shenoy, Vanteemar S Sreeraj, Janardhanan C Narayanaswamy, Ganesan Venkatasubramanian
Persistent auditory verbal hallucinations (AVH) that are refractory to antipsychotic medications are reported in about 20-30% of schizophrenia patients. Transcranial Direct Current Stimulation (tDCS), a non-invasive and safe neuromodulatory technique, has attracted significant interest as an add-on treatment for refractory AVH in schizophrenia. Studies examining the efficacy of tDCS for refractory AVH in schizophrenia have reported inconsistent findings. In this study, using a randomized, double-blind, sham-controlled design (RCT), we sought to examine the effect of add-on tDCS [anode corresponding to left dorsolateral prefrontal cortex and cathode to left temporo-parietal junction; 2-mA, twice-daily sessions for 5-days] to treat refractory AVH in schizophrenia patients (N=25); following this RCT phase, patients that had <30% reduction in AVH severity were offered an open-label extension (OLE) active stimulation to evaluate the effect of cross-over to verum tDCS...
August 30, 2017: Schizophrenia Research
https://www.readbyqxmd.com/read/28861736/identification-and-fine-mapping-of-a-new-gene-bph31-conferring-resistance-to-brown-planthopper-biotype-4-of-india-to-improve-rice-oryza-sativa-l
#5
G D Prahalada, N Shivakumar, H C Lohithaswa, D K Sidde Gowda, G Ramkumar, Sung-Ryul Kim, C Ramachandra, Shailaja Hittalmani, Trilochan Mohapatra, Kshirod K Jena
BACKGROUND: Rice (Oryza sativa L.) is the staple food for more than 3.5 billion people, mainly in Asia. Brown planthopper (BPH) is one of the most destructive insect pests of rice that limits rice production. Host-plant resistance is one of the most efficient ways to overcome BPH damage to the rice crop. RESULTS: BPH bioassay studies from 2009 to 2015 conducted in India and at the International Rice Research Institute (IRRI), Philippines, revealed that the cultivar CR2711-76 developed at the National Rice Research Institute (NRRI), Cuttack, India, showed stable and broad-spectrum resistance to several BPH populations of the Philippines and BPH biotype 4 of India...
August 31, 2017: Rice
https://www.readbyqxmd.com/read/28814142/effect-of-terpenes-on-transdermal-iontophoretic-delivery-of-diclofenac-potassium-under-constant-voltage
#6
Arunkumar S, Shivakumar H N, S Narasimha Murthy
PURPOSE: The aim of the study was to enhance the transdermal delivery of diclofenac potassium (DP) from hydrogels by constant voltage iontophoresis (CVI). The other objective was to establish the safety and efficacy of CVI in rats. METHODS: Hydrogels of DP were developed using hydroxyethyl cellulose as matrix material and geraniol, l-menthol and thymol as iontophoretic efficiency enhancers (IEE). In vitro permeation of hydrogels under CVI (1.5V) was performed in Franz diffusion cells across porcine skin...
August 17, 2017: Pharmaceutical Development and Technology
https://www.readbyqxmd.com/read/28813925/stereo-3d-tracking-of-infants-in-natural-play-conditions
#7
Shreyas S Shivakumar, Helen Loeb, Daniel K Bogen, Frances Shofer, Phillip Bryant, Laura Prosser, Michelle J Johnson
This paper describes the design and implementation of a multiple view stereoscopic 3D vision system and a supporting infant tracker pipeline to track limb movement in natural play environments and identify potential metrics to quantify movement behavior. So far, human pose estimation and tracking with 3D cameras has been focused primarily on adults and cannot be directly extended to infants because of differences in visual features such as shapes, sizes and appearance. With rehabilitation in mind, we propose a portable, compact, markerless, low cost and high resolution 3D vision system and a tracking algorithm that exploits infant appearance attributes and depth information...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28783938/neural-correlates-of-a-perspective-taking-task-using-in-a-realistic-three-dimmensional-environment-based-task-a-pilot-functional-magnetic-resonance-imaging-study
#8
Sri Mahavir Agarwal, Venkataram Shivakumar, Sunil V Kalmady, Vijay Danivas, Anekal C Amaresha, Anushree Bose, Janardhanan C Narayanaswamy, Michel-Ange Amorim, Ganesan Venkatasubramanian
Objective: Perspective-taking ability is an essential spatial faculty that is of much interest in both health and neuropsychiatric disorders. There is limited data on the neural correlates of perspective taking in the context of a realistic three-dimensional environment. We report the results of a pilot study exploring the same in eight healthy volunteers. Methods: Subjects underwent two runs of an experiment in a 3 Tesla magnetic resonance imaging (MRI) involving alternate blocks of a first-person perspective based allocentric object location memory task (OLMT), a third-person perspective based egocentric visual perspective taking task (VPRT), and a table task (TT) that served as a control...
August 31, 2017: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28763485/cxcr2-signaling-and-the-microbiome-suppress-inflammation-bile-duct-injury-and-the-phenotype-of-experimental-biliary-atresia
#9
Junbae Jee, Reena Mourya, Pranavkumar Shivakumar, Lin Fei, Michael Wagner, Jorge A Bezerra
Biliary atresia is progressive fibro-inflammatory cholangiopathy of young children. Central to pathogenic mechanisms of injury is the tissue targeting by the innate and adaptive immune cells. Among these cells, neutrophils and the IL-8/Cxcl-8 signaling via its Cxcr2 receptor have been linked to bile duct injury. Here, we aimed to investigate whether the intestinal microbiome modulates Cxcr2-dependent bile duct injury and obstruction. Adult wild-type (WT) and Cxcr2-/- mice were fed a diet supplemented with sulfamethoxazole/trimethoprim (SMZ/TMP) during pregnancy and lactation, and their pups were injected intraperitoneally with rhesus rotavirus (RRV) within 24 hours of life to induce experimental biliary atresia...
2017: PloS One
https://www.readbyqxmd.com/read/28757848/transnasal-sphenopalatine-ganglion-block-for-the-treatment-of-postdural-puncture-headache-following-spinal-anesthesia
#10
Shivakumar M Channabasappa, Shonali Manjunath, Basavaraj Bommalingappa, Sreenivas Ramachandra, S Banuprakash
No abstract text is available yet for this article.
July 2017: Saudi Journal of Anaesthesia
https://www.readbyqxmd.com/read/28756240/frequency-specific-modulation-of-connectivity-in-the-ipsilateral-sensorimotor-cortex-by-different-forms-of-movement-initiation
#11
Bin A Wang, Shivakumar Viswanathan, Rouhollah O Abdollahi, Nils Rosjat, Svitlana Popovych, Silvia Daun, Christian Grefkes, Gereon R Fink
A consistent finding in motor EEG research is a bilateral attenuation of oscillatory activity over sensorimotor regions close to the onset of an upcoming unilateral hand movement. In contrast, little is known about how movement initiation affects oscillatory activity, especially in the hemisphere ipsilateral to the moving hand. We here investigated the neural mechanisms modulating oscillatory activity in the ipsilateral motor cortex prior to movement onset under the control of two different initiating networks, namely, Self-initiated and Visually-cued actions...
July 26, 2017: NeuroImage
https://www.readbyqxmd.com/read/28752819/computer-assisted-navigation-in-total-knee-and-hip-arthroplasty
#12
Kamal Deep, Shivakumar Shankar, Ashish Mahendra
INTRODUCTION: Computer assisted surgery was pioneered in early 1990s. The first computer assisted surgery (CAS) total knee replacement with an imageless system was carried out in 1997. In the past 25 years, CAS has progressed from experimental in vitro studies to established in vivo surgical procedures. METHODS: A comprehensive body of evidence establishing the advantages of computer assisted surgery in knee and hip arthroplasty is available. Established benefits have been demonstrated including its role as an excellent research tool...
2017: SICOT-J
https://www.readbyqxmd.com/read/28751712/activation-of-mitophagy-leads-to-decline-in-mfn2-and-loss-of-mitochondrial-mass-in-fuchs-endothelial-corneal-dystrophy
#13
Anne-Sophie Benischke, Shivakumar Vasanth, Takashi Miyai, Kishore Reddy Katikireddy, Tomas White, Yuming Chen, Adna Halilovic, Marianne Price, Francis Price, Paloma B Liton, Ula V Jurkunas
Human corneal endothelial cells (HCEnCs) are terminally differentiated cells that have limited regenerative potential. The large numbers of mitochondria in HCEnCs are critical for pump and barrier function required for corneal hydration and transparency. Fuchs Endothelial Corneal Dystrophy (FECD) is a highly prevalent late-onset oxidative stress disorder characterized by progressive loss of HCEnCs. We previously reported increased mitochondrial fragmentation and reduced ATP and mtDNA copy number in FECD. Herein, carbonyl cyanide m-chlorophenyl hydrazone (CCCP)-induced mitochondrial depolarization decreased mitochondrial mass and Mfn2 levels, which were rescued with mitophagy blocker, bafilomycin, in FECD...
July 27, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28735405/profiling-abscisic-acid-induced-changes-in-fatty-acid-composition-in-mosses
#14
Suhas Shinde, Shivakumar Devaiah, Aruna Kilaru
In plants, change in lipid composition is a common response to various abiotic stresses. Lipid constituents of bryophytes are of particular interest as they differ from that of flowering plants. Unlike higher plants, mosses have high content of very long-chain polyunsaturated fatty acids. Such lipids are considered to be important for survival of nonvascular plants. Here, using abscisic acid (ABA )-induced changes in lipid composition in Physcomitrella patens as an example, a protocol for total lipid extraction and quantification by gas chromatography (GC) coupled with flame ionization detector (FID) is described...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28725021/bovine-milk-derived-exosomes-from-colostrum-are-enriched-with-proteins-implicated-in-immune-response-and-growth
#15
Monisha Samuel, David Chisanga, Michael Liem, Shivakumar Keerthikumar, Sushma Anand, Ching-Seng Ang, Christopher G Adda, Ellen Versteegen, Markandeya Jois, Suresh Mathivanan
Exosomes are extracellular vesicles secreted by multiple cell types into the extracellular space. They contain cell-state specific cargos which often reflects the (patho)physiological condition of the cells/organism. Milk contains high amounts of exosomes and it is unclear whether their cargo is altered based on the lactation stage of the organism. Here, we isolated exosomes from bovine milk that were obtained at various stages of lactation and examined the content by quantitative proteomics. Exosomes were isolated by OptiPrep density gradient centrifugation from milk obtained from cow after 24, 48 and 72 h post calving...
July 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28723280/case-248
#16
Aruna R Patil, Shrivalli Nandikoor, Govindarajan Mallarajapatna, Swarna Shivakumar
No abstract text is available yet for this article.
August 2017: Radiology
https://www.readbyqxmd.com/read/28722356/hansen-solubility-parameters-for-assay-method-optimization-of-simvastatin-ramipril-atenolol-hydrochlorothiazide-and-aspirin-in-human-plasma-using-liquid-chromatography-with-tandem-mass-spectrometry
#17
Murali Mohan Reddy Devalapalli, Hanumanth Srikanth Cheruvu, Thejaswi Yertha, Vijaya Bhaskar Veeravalli, Sunitha Sampathi, Savithri Shivakumar
A simple, specific, sensitive, validated method was developed using liquid chromatography with tandem mass spectrometry with electrospray ionization of human plasma for the simultaneous estimation of drugs (simvastatin, ramipril, atenolol, hydrochlorothiazide, and aspirin) of Polycap(TM) capsule used in cardiovascular therapy. The interaction of these actives including internal standards between the stationary and mobile phase were investigated using Hansen solubility parameters. Chromatographic separation was performed on Phenomenex Synergi Polar-RP (30 × 2 mm, 4 μm) column with a gradient mobile phase composition of acetonitrile and 5 mM ammonium formate for positive mode and 0...
July 19, 2017: Journal of Separation Science
https://www.readbyqxmd.com/read/28717418/a-novel-community-driven-software-for-functional-enrichment-analysis-of-extracellular-vesicles-data
#18
Mohashin Pathan, Shivakumar Keerthikumar, David Chisanga, Riccardo Alessandro, Ching-Seng Ang, Philip Askenase, Arsen O Batagov, Alberto Benito-Martin, Giovanni Camussi, Aled Clayton, Federica Collino, Dolores Di Vizio, Juan Manuel Falcon-Perez, Pedro Fonseca, Pamali Fonseka, Simona Fontana, Yong Song Gho, An Hendrix, Esther Nolte-'t Hoen, Nunzio Iraci, Kenneth Kastaniegaard, Thomas Kislinger, Joanna Kowal, Igor V Kurochkin, Tommaso Leonardi, Yaxuan Liang, Alicia Llorente, Taral R Lunavat, Sayantan Maji, Francesca Monteleone, Anders Øverbye, Theocharis Panaretakis, Tushar Patel, Héctor Peinado, Stefano Pluchino, Simona Principe, Goran Ronquist, Felix Royo, Susmita Sahoo, Cristiana Spinelli, Allan Stensballe, Clotilde Théry, Martijn J C van Herwijnen, Marca Wauben, Joanne L Welton, Kening Zhao, Suresh Mathivanan
Bioinformatics tools are imperative for the in depth analysis of heterogeneous high-throughput data. Most of the software tools are developed by specific laboratories or groups or companies wherein they are designed to perform the required analysis for the group. However, such software tools may fail to capture "what the community needs in a tool". Here, we describe a novel community-driven approach to build a comprehensive functional enrichment analysis tool. Using the existing FunRich tool as a template, we invited researchers to request additional features and/or changes...
2017: Journal of Extracellular Vesicles
https://www.readbyqxmd.com/read/28680172/direct-oral-anticoagulants-and-vitamin-k-antagonists-for-treatment-of-deep-venous-thrombosis-and-pulmonary-embolism-in-the-outpatient-setting-comparative-economic-evaluation
#19
Abdullah S Al Saleh, Patrick Berrigan, David Anderson, Sudeep Shivakumar
BACKGROUND: To date, there have been few economic evaluations, from a Canadian perspective, of direct oral anticoagulants (DOACs) for the prevention of recurrent venous thromboembolism (VTE) in patients with acute unprovoked VTE. As a result, there is a lack of consensus about which treatment strategy should be adopted in the clinical setting. OBJECTIVES: To assess the cost-effectiveness of currently approved anti-coagulant options, in terms of cost per quality-adjusted life-year (QALY) gained, for the prevention of recurrent VTE in patients with unprovoked events managed on an outpatient basis...
May 2017: Canadian Journal of Hospital Pharmacy
https://www.readbyqxmd.com/read/28665015/autotransporter-adhesins-in-escherichia-coli-pathogenesis
#20
REVIEW
Julieanne L Vo, Gabriela Constanza Martínez Ortiz, Pramod Subedi, Shivakumar Keerthikumar, Suresh Mathivanan, Jason J Paxman, Begoña Heras
Most bacteria produce adhesion molecules to facilitate the interaction with host cells and establish successful infections. An important group of bacterial adhesins belong to the autotransporter (AT) superfamily, the largest group of secreted and outer membrane proteins in Gram-negative bacteria. AT adhesins possess diverse functions that facilitate bacterial colonisation, survival and persistence, and as such are often associated with increased bacterial fitness and pathogenic potential. In this review, we will describe AIDA-I type AT adhesins, which comprise the biggest and most diverse group in the AT family...
June 30, 2017: Proteomics
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