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https://www.readbyqxmd.com/read/28298833/minimally-invasive-maxillary-sinus-elevation-using-balloon-system-a-case-series
#1
Radha Bharathi Dhandapani, Shivakumar Baskaran, Kurumathur Vasudevan Arun, Thirunelveli Saravanan Subbu Kumar
The posterior maxillary segment frequently exhibits insufficient bone mass to support dental implants. Sinus floor augmentation enables implant placement in the posterior maxilla. This case series included ten sites, in which sinus floor elevation was done using sinus lift balloon system followed by augmentation utilizing irradiated cancellous bone allograft. Postoperative radiographic assessment of vertical bone gain was done at 3 and 6 months follow-up period. The mean initial and final bone height were 6...
July 2016: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/28289970/trans-ungual-delivery-of-ar-12-a-novel-antifungal-drug
#2
Avadhesh Singh Kushwaha, P Sharma, H N Shivakumar, C Rappleye, A Zukiwski, S Proniuk, S Narasimha Murthy
AR-12 is a novel small molecule with broad spectrum antifungal activity. Recently, AR-12 was found to be highly active against Trichophyton rubrum, one of the predominantly responsible organisms that cause onychomycosis. The primary objective of this project was to investigate the ability of AR-12 to penetrate into and across the human nail plate followed by improving its trans-ungual permeation using different penetration enhancers. TranScreen-N™, a high throughput screening method was utilized to explore the potential nail penetration enhancers to facilitate the drug delivery through the nail...
March 13, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28289704/preferential-tnf%C3%AE-signaling-via-tnfr2-regulates-epithelial-injury-and-duct-obstruction-in-experimental-biliary-atresia
#3
Pranavkumar Shivakumar, Tatsuki Mizuochi, Reena Mourya, Sridevi Gutta, Li Yang, Zhenhua Luo, Jorge A Bezerra
Biliary atresia is an obstructive cholangiopathy of infancy that progresses to end-stage cirrhosis. Although the pathogenesis of the disease is not completely understood, previous reports link TNFα to apoptosis of the bile duct epithelium in the presence of IFNγ. Here, we investigate if TNFα signaling regulates pathogenic mechanisms of biliary atresia. First, we quantified the expression of TNFA and its receptors TNFR1 and TNFR2 in human livers and found an increased expression of the receptors at the time of diagnosis...
March 9, 2017: JCI Insight
https://www.readbyqxmd.com/read/28283227/clozapine-as-the-most-efficacious-antipsychotic-for-activating-erk-1-2-kinases-role-of-5-ht2a-receptor-agonism
#4
Stefano Aringhieri, Shivakumar Kolachalam, Claudio Gerace, Marco Carli, Valeria Verdesca, Maria Giulia Brunacci, Chiara Rossi, Chiara Ippolito, Anna Solini, Giovanni U Corsini, Marco Scarselli
Antipsychotics (APDs) are divided into first-generation antipsychotics (FGAs) and second-generation antipsychotics (SGAs) based on the concept that SGAs have reduced motor side effects. With this premise, this study examined in HeLa and other cell lines the effects of different APDs on the activation of ERK1/2 (Extracellular signal-regulated kinases) and AKT (Protein Kinase B) kinases, which may be affected in schizophrenia and bipolar disorder. Among the SGAs, Clozapine clearly resulted as the most effective drug inducing ERK1/2 phosphorylation with potency in the low micromolar range...
March 7, 2017: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28278318/association-of-pseudoexfoliation-with-systemic-vascular-diseases-in-a-south-indian-population
#5
Ashok Vardhan S, Aravind Haripriya, Banushree Ratukondla, Pradeep Ramulu, Chandrasekaran Shivakumar, Manas Nath, Prabhu Vijayaraghavan, Alan L Robin
Importance: Ocular pseudoexfoliation (PEX) syndrome may be associated with systemic vascular diseases, which might suggest a broader health significance of PEX, although previous reports are conflicting. Objective: To determine whether prespecified vascular risk factors and cardiac abnormalities are more common among patients with PEX than among control individuals without PEX. Design, Setting, and Participants: This cross-sectional analysis of patients recruited into the Aravind Pseudoexfoliation study included South Indian patients older than 40 years with or without PEX who required cataract surgery...
March 9, 2017: JAMA Ophthalmology
https://www.readbyqxmd.com/read/28275009/paracrine-signals-regulate-human-liver-organoid-maturation-from-ipsc
#6
Akihiro Asai, Eitaro Aihara, Carey Watson, Reena Mourya, Tatsuki Mizuochi, Pranavkumar Shivakumar, Kieran Phelan, Christopher Mayhew, Michael Helmrath, Takanori Takebe, James Wells, Jorge A Bezerra
A self-organizing organoid model provides a new approach to study the mechanism of human liver organogenesis. Previous animal models documented that simultaneous paracrine signaling and cell-to-cell surface contact regulate hepatocyte differentiation. To dissect the relative contributions of the paracrine effects, we first established a liver organoid using human induced pluripotent stem cells (iPSC), mesenchymal stem cells (MSC), and human umbilical vein endothelial cells (HUVEC) as previously reported. Time-lapse imaging showed the iPSC-derived hepatic endoderm (HE-iPSC) self-assembled into three-dimensional organoids, resulting in hepatic gene induction...
March 8, 2017: Development
https://www.readbyqxmd.com/read/28273985/giant-antrochoanal-polyp-a-rare-presentation
#7
Swati Kodur, Shruti Malavalli Siddappa, Andanooru Mahalingappa Shivakumar
Antrochoanal polyp (ACP), also called as Killian polyp, is an infrequent, benign lesion of maxillary origin in non-atopic patients. The antrochoanal polyp is shaped according to the anatomical constraints of the lateral nasal wall, particularly the middle meatus and antrum, resembling typically a dumbbell. Here presenting a common problem with unusual presentation.
January 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28266094/controlled-growth-of-gold-nanostars-effect-of-spike-length-on-sers-signal-enhancement
#8
Ganesh Venkatachalam, S V Sheen Mers, Shivakumar Umadevi
In this work, two different types of gold nanostars (Au NS) namely short-spiked nanostars (SSNS) and long-spiked nanostars (LSNS) are prepared by using hexagonal lyotropic liquid crystalline (LLC) phase as a template. Basically the formation, size and length of spikes or arms of the resultant Au NS are controlled by preparation either in a hexagonal LLC phase or in an isotropic phase. These NS are anchored onto ITO electrodes through self-assembled monolayer (SAM) of 3-mercaptopropyltrimethoxysilane (MPTMS) acting as a linker molecule...
March 7, 2017: Chemphyschem: a European Journal of Chemical Physics and Physical Chemistry
https://www.readbyqxmd.com/read/28262134/interventions-in-adhd-a-comparative-review-of-stimulant-medications-and-behavioral-therapies
#9
REVIEW
Adnan Rajeh, Shabbir Amanullah, K Shivakumar, Julie Cole
ADHD has a prevalence of approximately 10% in children with evidence supporting it's continuance into adulthood. This has a significant impact on how we address treatment at substance abuse facilities and also has implications for personal and occupational functioning. A lack of evidence to support the superiority of any one intervention over the other has created difficulties for both clinicians and parents. A recent review highlights long-term and short-term outcomes (Craig et al., 2015). This article reviews the benefits and pitfalls of both pharmacological interventions and behavioral therapies in the treatment of ADHD...
February 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/28256460/international-open-trial-of-uniform-multidrug-therapy-regimen-for-leprosy-patients-findings-implications-for-national-leprosy-programmes
#10
Ponnaiah Manickam, Sanjay M Mehendale, Bathyala Nagaraju, Kiran Katoch, Abdul Jamesh, Ramalingam Kutaiyan, Shen Jianping, Shivakumar Mugudalabetta, Vitthal Jadhav, Prabu Rajkumar, Jayasree Padma, Kanagasabai Kaliaperumal, Vijayakumar Pannikar, Padabettu Krishnamurthy, Mohan D Gupte
BACKGROUND & OBJECTIVES: Uniform therapy for all leprosy patients will simplify leprosy treatment. In this context, we evaluated six-month multidrug therapy (MDT) currently recommended for multibacillary (MB) patients as uniform MDT (U-MDT) in a single-arm open trial under programme conditions. Primary objective was to determine efficacy to prevent five-year cumulative five per cent relapse. Secondary objectives were to assess acceptability, safety and compliance. METHODS: Newly detected, treatment-naive leprosy patients were enrolled in India (six sites) and P...
October 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28250567/feasibility-of-online-neuromodulation-using-transcranial-alternating-current-stimulation-in-schizophrenia
#11
Vanteemar S Sreeraj, Vandita Shanbhag, Hema Nawani, Venkataram Shivakumar, Dinakaran Damodharan, Anushree Bose, Janardhanan C Narayanaswamy, Ganesan Venkatasubramanian
Abnormalities in resting and event-related brain oscillations are known to be associated with cognitive deficits in schizophrenia. Transcranial alternating current stimulation (tACS) modulates these rhythms across the neuronal circuits and could have a potential therapeutic role in psychiatric disorders. In this report, we describe, for the first time, application of online tACS in a schizophrenia patient with working memory deficits. This case report supports the feasibility and potential utility of online tACS in schizophrenia, which needs further systematic research...
January 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/28250483/intravenous-palonosetron-compared-with-a-combination-of-ramosetron-and-dexamethasone-in-preventing-post-operative-nausea-and-vomiting-in-patients-undergoing-gynaecological-surgeries-under-spinal-anaesthesia-a-randomised-study
#12
Archana B Narayanappa, Shivakumar Gurulingaswamy, Umesh N Prabhakaraiah, Somsundar R Gurushanth, Vinay Sapare, Nagaraj Goud
BACKGROUND AND AIMS: Post-operative nausea and vomiting (PONV) is one of the most common complications in patients undergoing gynaecological surgeries under spinal anaesthesia (SA). Palonosetron has the unique property of controlling 'delayed chemotherapy-induced nausea and vomiting' when compared to older serotonin antagonists. This study compared the effectiveness of palonosetron with a combination of ramosetron and dexamethasone in preventing PONV. METHODS: Sixty patients undergoing gynaecological surgeries under SA were randomly allocated into two groups of thirty each, to receive either a combination of 0...
February 2017: Indian Journal of Anaesthesia
https://www.readbyqxmd.com/read/28229801/successful-implantation-of-a-renal-allograft-with-quintuple-arteries-retrieved-from-a-living-donor
#13
Sunil Kumar, Nikhil Mahajan, Soham Dasgupta, Shivakumar Shankarrao Patil, Sarbpreet Singh, Deepesh Benjamin Kenwar, Manphool Singhal, Ashish Sharma, Anupam Lal, Mukut Minz
In renal transplant, multiple renal arteries in a donor require meticulous vascular reconstruction for successful allograft function in the recipient. Presence of more than 4 renal arteries is usually considered to be a relative contraindication for proceeding with renal donation. We report a living-donor renal transplant procedure where preoperative radiologic imaging of the donor showed 3 left renal arteries. Two additional arteries were identified intraoperatively. All 5 arteries were reconstructed during the back-table procedure, and the allograft was implanted in the recipient...
February 23, 2017: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/28172447/powerful-differential-expression-analysis-incorporating-network-topology-for-next-generation-sequencing-data
#14
Malathi Si Dona, Luke A Prendergast, Suresh Mathivanan, Shivakumar Keerthikumar, Agus Salim
No abstract text is available yet for this article.
January 5, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28160670/cost-effectiveness-of-the-addition-of-a-comprehensive-ct-scan-to-the-abdomen-and-pelvis-for-the-detection-of-cancer-after-unprovoked-venous-thromboembolism
#15
Kathryn Coyle, Marc Carrier, Alejandro Lazo-Langner, Sudeep Shivakumar, Ryan Zarychanski, Vicky Tagalakis, Susan Solymoss, Nathalie Routhier, James Douketis, Douglas Coyle
IMPORTANCE: Unprovoked venous thromboembolism (VTE) can be the first manifestation of cancer. It is unclear if extensive screening for occult cancer including a comprehensive computed tomography (CT) scan of the abdomen/pelvis is cost-effective in this patient population. OBJECTIVE: To assess the health care related costs, number of missed cancer cases and health related utility values of a limited screening strategy with and without the addition of a comprehensive CT scan of the abdomen/pelvis and to identify to what extent testing should be done in these circumstances to allow early detection of occult cancers...
January 25, 2017: Thrombosis Research
https://www.readbyqxmd.com/read/28152388/spectral-characterization-and-antibacterial-activity-of-an-isolated-compound-from-memecylon-edule-leaves
#16
R Srinivasan, D Natarajan, M S Shivakumar
Memecylon edule Roxb. (Melastamataceae family) is a small evergreen tree reported as having ethnobotanical and pharmacological properties. The present study was aimed to investigate the spectral characterization and antibacterial activity of isolated pure compound (3β-hydroxyurs-12-en-28-oic acid (ursolic acid)) from Memecylon edule leaves by performing bioassay guided isolation method. The structure derivation of isolated compound was done by different spectral studies like UV, FT-IR, LC-MS, CHNS analysis, 1D ((1)H, (13)C and DEPT-135) and 2D-NMR (HSQC and HMBC), respectively...
January 21, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28114163/doppler-ultrasonography-of-the-central-retinal-vessels-in-children-with-brain-death
#17
Becky J Riggs, Joanna S Cohen, Bhavana Shivakumar, Carmelina Trimboli-Heidler, Jason T Patregnani, Marijean M Miller, Michael C Spaeder, Nathan P Dean
OBJECTIVE: The purpose of this observational study is to explore if bedside Doppler ultrasonography of the central retinal vessels has the potential to become an ancillary study to support the timely diagnosis of brain death in children. DESIGN: Seventeen-month prospective observational cohort. SETTING: Forty-four bed pediatric medical and surgical ICU in an academic teaching hospital. PATIENTS: All children 0-18 years old who were clinically evaluated for brain death at Children's National Health Systems were enrolled and followed until discharge or death...
March 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/28100636/centriole-splitting-caused-by-loss-of-the-centrosomal-linker-protein-c-nap1-reduces-centriolar-satellite-density-and-impedes-centrosome-amplification
#18
Anne-Marie Flanagan, Elena Stavenschi, Shivakumar Basavaraju, David Gaboriau, David A Hoey, Ciaran G Morrison
Duplication of the centrosomes is a tightly regulated process. Abnormal centrosome numbers can impair cell division and cause changes in how cells migrate. Duplicated centrosomes are held together by a proteinaceous linker made up of rootletin filaments anchored to the centrioles by C-NAP1. This linker is removed in a NEK2A kinase-dependent manner as mitosis begins. To explore C-NAP1 activities in regulating centrosome activities, we used genome editing to ablate it. C-NAP1 null cells were viable and had an increased frequency of premature centriole separation, accompanied by reduced density of the centriolar satellites, with re-expression of C-NAP1 rescuing both these phenotypes...
January 18, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28096585/comparison-of-three-insertion-techniques-of-proseal-laryngeal-mask-airway-a-randomized-clinical-trial
#19
Kadirehally Bheemanna Nalini, Shivanna Shivakumar, Shivashankar Archana, Doddagavanahalli Channaiah Sandhya Rani, Chadalavada Venkata Rama Mohan
BACKGROUND AND AIMS: We aimed to compare three techniques for insertion of ProSeal laryngeal mask airway (PLMA). MATERIAL AND METHODS: Two hundred ten patients (American Society of Anaethesiologists I-II, aged 18-60 years) undergoing general anesthesia using the PLMA as an airway management device were randomly allocated to digital (D), rotational (R), or pharyngoscopic (P) techniques. In the D group (n = 70), the PLMA insertion was performed by using digital manipulation...
October 2016: Journal of Anaesthesiology, Clinical Pharmacology
https://www.readbyqxmd.com/read/28010773/biosynthesis-of-silver-nanoparticles-using-pre-hydrolysis-liquor-of-eucalyptus-wood-and-its-effective-antimicrobial-activity
#20
M Shivakumar, K L Nagashree, S Yallappa, S Manjappa, K S Manjunath, M S Dharmaprakash
Herein, we described for the first time, biosynthesis of silver nanoparticles (AgNPs) using pre-hydrolyzed liquor of Eucalyptus wood under ambient conditions. The pre-hydrolyzed liquor containing a high amount of metabolites such as polyphenols, hemicelluloses and its derivatives are mainly assisted for the reduction and stabilization process of Ag+ ions to AgNPs. The formation of AgNPs is monitored by recording the UV-vis spectrophotometer for surface plasmon resonance (SPR) peak observed at ∼415nm. The intensity of SPR increased linearly with increasing the reaction time at ambient condition...
February 2017: Enzyme and Microbial Technology
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