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https://www.readbyqxmd.com/read/29337589/critical-review-on-the-analytical-mechanistic-steps-in-the-evaluation-of-antioxidant-activity
#1
Anantharaman Shivakumar, M S Yogendra Kumar
Electrophysiological systems are prone to release free radicals for functioning of biological system with proper balancing of antioxidant-prooxidant ratio for establishing a healthy living system. The biostress condition releases different reactive oxygen species, such as hydroxyl, alkoxyl, superoxide, hydrogen peroxide, hydroperoxyl, ozone, singlet oxygen, hypochlorus acid, thiyl radical, etc. This review tries to discuss the general aspects of the antioxidant assay methodologies that are currently used for the detection of antioxidant property...
January 16, 2018: Critical Reviews in Analytical Chemistry
https://www.readbyqxmd.com/read/29334771/development-of-anti-human-mesothelin-targeted-chimeric-antigen-receptor-car-messenger-rna-mrna-transfected-peripheral-blood-lymphocytes-carma-hmeso-for-ovarian-cancer-therapy
#2
Chien-Fu Hung, Xuequn Xu, Linhong Li, Ying Ma, Qiu Jin, Angelia Viley, Cornell Allen, Pachai Natarajan, Rama Shivakumar, Madhusudan V Peshwa, Leisha A Emens
CD19-targeted chimeric antigen receptor (CAR) engineered T/natural kill (NK)-cell therapies can result in durable clinical responses in B-cell malignancies. However, CAR-based immunotherapies have been much less successful in solid cancers, in part due to 'on-target off-tumor' toxicity related to expression of target tumor antigens on normal tissue. Based on preliminary observations of safety and clinical activity in proof-of-concept clinical trials, tumor antigen-specific messenger RNA (mRNA) CAR transfection into selected, activated, and expanded T/NK-cells may permit prospective control of 'on-target off-tumor toxicity'...
January 15, 2018: Human Gene Therapy
https://www.readbyqxmd.com/read/29330282/population-dependent-intron-retention-and-dna-methylation-in-breast-cancer
#3
Dongwook Kim, Manu Shivakumar, Seonggyun Han, Michael S Sinclair, Youngji Lee, Yonglan Zheng, Olufunmilayo I Olopade, Dokyoon Kim, Younghee Lee
Regulation of gene expression by DNA methylation in gene promoter regions is well-studied; however, the effects of methylation in the gene body (exons and introns) on gene expression are comparatively understudied. Recently, hyper-methylation has been implicated in the inclusion of alternatively spliced exons; moreover, exon recognition can be enhanced by recruiting the methyl-CpG-binding protein (MeCP2) to hyper-methylated sites. This study examines if methylation status of an intron is correlated with how frequently the intron is retained during splicing using DNA methylation and RNA sequencing (RNA-seq) data from breast cancer tissue specimens in The Cancer Genome Atlas (TCGA)...
January 12, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29325707/successful-creation-of-pancreatic-cancer-organoids-by-means-of-eus-guided-fine-needle-biopsy-for-personalized-cancer-treatment
#4
Herve Tiriac, Juan Carlos Bucobo, Demetrios Tzimas, Suman Grewel, Joseph F Lacomb, Leahana M Rowehl, Satish Nagula, Maoxin Wu, Joseph Kim, Aaron Sasson, Shivakumar Vignesh, Laura Martello, Maria Munoz-Sagastibelza, Jonathan Somma, David A Tuveson, Ellen Li, Jonathan M Buscaglia
BACKGROUND AND AIMS: Pancreatic cancer organoids are tumor models of individualized human pancreatic ductal adenocarcinoma (PDA), created from surgical specimens and used for personalized treatment strategies. Unfortunately the vast majority of patients with PDA are not operative candidates. Creation of human PDA organoids at the time of initial tumor diagnosis is therefore critical. Our aim was to assess the feasibility of creating human PDA organoids by EUS fine-needle biopsy (EUS-FNB) in patients with PDA...
January 8, 2018: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/29317568/comparative-efficacy-and-safety-of-caffeine-and-aminophylline-for-apnea-of-prematurity-few-concerns-author-s-reply
#5
M Shivakumar, Leslie Edward Simon Lewis
No abstract text is available yet for this article.
December 15, 2017: Indian Pediatrics
https://www.readbyqxmd.com/read/29305655/chrfam7a-gene-expression-in-schizophrenia-clinical-correlates-and-the-effect-of-antipsychotic-treatment
#6
Sunil V Kalmady, Rimjhim Agrawal, Deepthi Venugopal, Venkataram Shivakumar, Anekal C Amaresha, Sri Mahavir Agarwal, Manjula Subbanna, Ashwini Rajasekaran, Janardhanan C Narayanaswamy, Monojit Debnath, Ganesan Venkatasubramanian
Earlier studies have implicated CHRNA7, coding α-7 nicotinic acetylcholine receptor (α7 nAChR), and its partially duplicated chimeric gene CHRFAM7A in schizophrenia. However, the relationship between the alterations in peripheral gene expression of CHRFAM7A and severity of clinical symptoms has not been examined. Furthermore, potential influence of the antipsychotic medication on CHRFAM7A expression in drug-naive or drug-free schizophrenia is an unexplored area. CHRFAM7A gene expression in lymphocytes was analyzed in 90 antipsychotic-naïve or free schizophrenia patients using TaqMan-based quantitative RT-PCR...
January 5, 2018: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29300757/the-effects-of-alternative-splicing-on-mirna-binding-sites-in-bladder-cancer
#7
Seonggyun Han, Dongwook Kim, Manu Shivakumar, Young-Ji Lee, Tullika Garg, Jason E Miller, Ju Han Kim, Dokyoon Kim, Younghee Lee
Eukaryotic organisms have developed a variety of mechanisms to regulate translation post-transcriptionally, including but not limited to the use of miRNA silencing in many species. One method of post-transcriptional regulation is through miRNAs that bind to the 3' UTRs to regulate mRNA abundance and influence protein expression. Therefore, the diversity of mRNA 3' UTRs mediating miRNA binding sites influence miRNA-mediated regulation. Alternative polyadenylation, by shortening mRNA isoforms, increases the diversity of 3' UTRs; moreover, short mRNA isoforms elude miRNA-medicated repression...
2018: PloS One
https://www.readbyqxmd.com/read/29286928/long-term-neurodevelopment-outcome-of-caffeine-versus-aminophylline-therapy-for-apnea-of-prematurity
#8
S Khurana, M Shivakumar, G V Sujith Kumar Reddy, P Jayashree, Y Ramesh Bhat, L E S Lewis
OBJECTIVE: Methylxanthines are the most commonly prescribed drug in neonatal setups. However, Clinicians show indecision in choosing the right agent for Apnea of Prematurity in most of the developing countries. Present study aimed to compare rate of mortality and survival with normal neurodevelopment outcome at 18 to 24 months of corrected age, between Caffeine- and Aminophylline-treated infants for apnea of prematurity. METHODS: 240 infants were randomly allocated to caffeine and aminophylline for apnea of prematurity during February 2012 to January 2015...
2017: Journal of Neonatal-perinatal Medicine
https://www.readbyqxmd.com/read/29284839/-comparison-of-nalbuphine-hydrochloride-and-fentanyl-as-an-adjuvant-to-bupivacaine-for-spinal-anesthesia-in-lower-abdominal-surgeries-a-randomized-double-blind-study
#9
Umesh N Prabhakaraiah, Archana B Narayanappa, Shivakumar Gurulingaswamy, Krishna Kempegowda, Kiran A Vijaynagar, Nagarajaiah B Hanumantharayappa, Diwakar S Ramegowda
Background and Aims: Opioids have been favored as adjuvants to local anesthetics during spinal anesthesia. Nalbuphine, a μ-receptor antagonist and ĸ-receptor agonist, seems to be a suitable adjuvant to local anesthetics. The aim of this study was to compare postoperative analgesia and adverse effects of nalbuphine and fentanyl when used as an adjuvant to hyperbaric bupivacaine during spinal anesthesia. Materials and Methods: Sixty patients belonging to the American Society of Anesthesiologists Physical Status I and II were randomly allocated into two groups of thirty each...
October 2017: Anesthesia, Essays and Researches
https://www.readbyqxmd.com/read/29284822/right-sided-transcranial-direct-current-stimulation-and-attentional-salience-of-auditory-hallucinations-in-schizophrenia
#10
Damodharan Dinakaran, Rujuta Parlikar, Vanteemar S Sreeraj, Anuradha Neikar, Sachin Nagendrappa, Venkataram Shivakumar, Ganesan Venkatasubramanian
Transcranial direct current stimulation (tDCS) is a safe, noninvasive technique demonstrated to reduce persistent auditory hallucinations in patients with schizophrenia. Here, we report the differential effect of tDCS on auditory hallucinations against other positive symptoms and also the use of right-sided tDCS in patients with increased attentional salience toward auditory hallucinations.
November 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29259147/feasibility-and-clinical-utility-of-high-definition-transcranial-direct-current-stimulation-in-the-treatment-of-persistent-hallucinations-in-schizophrenia
#11
A Bose, V Shivakumar, H Chhabra, R Parlikar, V S Sreeraj, D Dinakaran, J C Narayanaswamy, G Venkatasubramanian
Persistent auditory verbal hallucination is a clinically significant problem in schizophrenia. Recent studies suggest a promising role for add-on transcranial direct current stimulation (tDCS) in treatment. An optimised version of tDCS, namely high-definition tDCS (HD-tDCS), uses smaller electrodes arranged in a 4x1 ring configuration and may offer more focal and predictable neuromodulation than conventional tDCS. This case report illustrates the feasibility and clinical utility of add-on HD-tDCS over the left temporoparietal junction in a 4x1 ring configuration to treat persistent auditory verbal hallucination in schizophrenia...
December 2017: East Asian Archives of Psychiatry: Official Journal of the Hong Kong College of Psychiatrists
https://www.readbyqxmd.com/read/29230449/conducting-nanofibres-of-solvatofluorochromic-cyclohexanetrione-dithiolylidene-based-c3-symmetric-molecule
#12
Kilingaru I Shivakumar, Goudappagouda, Rajesh G Gonnade, Sukumaran Santhosh Babu, Gangadhar J Sanjayan
We report a novel set of easily tailorable C3 symmetric molecules with a π-extended core and adorned with different thioalkyl groups, exhibiting solvatofluorochromic and amphoteric redox behaviour. The nearly planar core exhibits intermolecular face-to-face π-stacking, SS and intramolecular SO interactions. Current-sensing atomic force microscopy studies revealed a high conductivity of ∼0.15 mS cm-1 in the undoped J-aggregate nanofibres of the thiopropyl appended gelator.
December 12, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29218897/codon-bias-among-synonymous-rare-variants-is-associated-with-alzheimer-s-disease-imaging-biomarker
#13
Jason E Miller, Manu K Shivakumar, Shannon L Risacher, Andrew J Saykin, Seunggeun Lee, Kwangsik Nho, Dokyoon Kim
Alzheimer's disease (AD) is a neurodegenerative disorder with few biomarkers even though it impacts a relatively large portion of the population and is predicted to affect significantly more individuals in the future. Neuroimaging has been used in concert with genetic information to improve our understanding in relation to how AD arises and how it can be potentially diagnosed. Additionally, evidence suggests synonymous variants can have a functional impact on gene regulatory mechanisms, including those related to AD...
2018: Pacific Symposium on Biocomputing
https://www.readbyqxmd.com/read/29217401/influence-of-correlation-between-hla-g-polymorphism-and-interleukin-6-il6-gene-expression-on-the-risk-of-schizophrenia
#14
Venkataram Shivakumar, Monojit Debnath, Deepthi Venugopal, Ashwini Rajasekaran, Sunil V Kalmady, Manjula Subbanna, Janardhanan C Narayanaswamy, Anekal C Amaresha, Ganesan Venkatasubramanian
Converging evidence suggests important implications of immuno-inflammatory pathway in the risk and progression of schizophrenia. Prenatal infection resulting in maternal immune activation and developmental neuroinflammation reportedly increases the risk of schizophrenia in the offspring by generating pro-inflammatory cytokines including IL-6. However, it is not known how prenatal infection can induce immuno-inflammatory responses despite the presence of immuno-inhibitory Human Leukocyte Antigen-G (HLA-G) molecules...
December 4, 2017: Cytokine
https://www.readbyqxmd.com/read/29212129/the-perioperative-anticoagulant-use-for-surgery-evaluation-pause-study-for-patients-on-a-direct-oral-anticoagulant-who-need-an-elective-surgery-or-procedure-design-and-rationale
#15
James D Douketis, Alex C Spyropoulos, Julia M Anderson, Donald M Arnold, Shannon M Bates, Mark Blostein, Marc Carrier, Joseph A Caprini, Nathan P Clark, Michiel Coppens, Francesco Dentali, Joanne Duncan, Peter L Gross, Jeannine Kassis, Stephen Kowalski, Agnes Y Lee, Gregoire Le Gal, Geneviève Le Templier, Na Li, Elizabeth MacKay, Vinay Shah, Sudeep Shivakumar, Susan Solymoss, Frederick A Spencer, Summer Syed, Alfonso J Tafur, Thomas Vanassche, Thomas Thiele, Cynthia Wu, Erik Yeo, Sam Schulman
No abstract text is available yet for this article.
December 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29204746/comparative-analysis-of-human-wharton-s-jelly-mesenchymal-stem-cells-derived-from-different-parts-of-the-same-umbilical-cord
#16
Dinesh Bharti, Sharath Belame Shivakumar, Ji-Kwon Park, Imran Ullah, Raghavendra Baregundi Subbarao, Ji-Sung Park, Sung-Lim Lee, Bong-Wook Park, Gyu-Jin Rho
Easy isolation, lack of ethical issues, high proliferation, multi-lineage differentiation potential and immunomodulatory properties of umbilical cord (UC)-derived mesenchymal stem cells (MSCs) make them a valuable tool in stem cell research. Recently, Wharton's jelly (WJ) was proven as the best MSC source among various compartments of UC. However, it is still unclear whether or not Wharton's jelly-derived MSCs (WJMSCs) from different parts of the whole cord exhibit the same characteristics. There may be varied MSCs present in different parts of WJ throughout the length of the UC...
December 4, 2017: Cell and Tissue Research
https://www.readbyqxmd.com/read/29200956/stem-cells-from-cryopreserved-human-dental-pulp-tissues-sequentially-differentiate-into-definitive-endoderm-and-hepatocyte-like-cells-in-vitro
#17
Young-Jin Han, Young-Hoon Kang, Sarath Belame Shivakumar, Dinesh Bharti, Young-Bum Son, Yong-Ho Choi, Won-Uk Park, June-Ho Byun, Gyu-Jin Rho, Bong-Wook Park
We previously described a novel tissue cryopreservation protocol to enable the safe preservation of various autologous stem cell sources. The present study characterized the stem cells derived from long-term cryopreserved dental pulp tissues (hDPSCs-cryo) and analyzed their differentiation into definitive endoderm (DE) and hepatocyte-like cells (HLCs) in vitro. Human dental pulp tissues from extracted wisdom teeth were cryopreserved as per a slow freezing tissue cryopreservation protocol for at least a year...
2017: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29200573/neural-effects-of-transcranial-direct-current-stimulation-in-schizophrenia-a-case-study-using-functional-near-infrared-spectroscopy
#18
S Trevor Taylor, Harleen Chhabra, Vanteemar S Sreeraj, Venkataram Shivakumar, Sunil V Kalmady, Ganesan Venkatasubramanian
Schizophrenia is a severe neuropsychiatric disorder characterized by delusions, hallucinations, behavioral symptoms, and cognitive deficits. Roughly, 70%-80% of schizophrenia patients experience auditory verbal hallucinations (AVHs), with 25%-30% demonstrating resistance to conventional antipsychotic medications. Studies suggest a promising role for add-on transcranial direct current stimulation (tDCS) in the treatment of medication-refractory AVHs. The mechanisms through which tDCS could be therapeutic in such cases are unclear, but possibly involve neuroplastic effects...
September 2017: Indian Journal of Psychological Medicine
https://www.readbyqxmd.com/read/29184620/large-pericardial-mass-mimicking-pericardial-effusion
#19
Shilpa Jayaprakash, Shivakumar Byrappa, S S Prakash, S Shankar
No abstract text is available yet for this article.
July 2017: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/29176853/age-related-changes-in-oscillatory-power-affect-motor-action
#20
Liqing Liu, Nils Rosjat, Svitlana Popovych, Bin A Wang, Azamat Yeldesbay, Tibor I Toth, Shivakumar Viswanathan, Christian B Grefkes, Gereon R Fink, Silvia Daun
With increasing age cognitive performance slows down. This includes cognitive processes essential for motor performance. Additionally, performance of motor tasks becomes less accurate. The objective of the present study was to identify general neural correlates underlying age-related behavioral slowing and the reduction in motor task accuracy. To this end, we continuously recorded EEG activity from 18 younger and 24 older right-handed healthy participants while they were performing a simple finger tapping task...
2017: PloS One
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