keyword
https://read.qxmd.com/read/38520278/incidence-and-risk-factors-for-icu-associated-delirium-in-the-alert-geriatric-trauma-population
#1
JOURNAL ARTICLE
Sarah C Ulderich Williams, Ansam I Qaddoumi, John T Meghreblian, Mary E McBride, Sarah A King, Muhammad A Elahi, Debbie Tuggle, R Eric Heidel, Lou M Smith
BACKGROUND: This study analyzed the overall incidence of delirium, comorbid conditions, injury patterns, and pharmacological risk factors for the development of delirium in an alert, geriatric trauma population. METHODS: IRB-approved, prospective, consecutive cohort series at two Southeastern Level 1 trauma centers from June 11 to August 15, 2023. Delirium was assessed using the Confusion Assessment Method (CAM) score. Comorbidities and medications were detailed from electronic medical records...
March 23, 2024: American Surgeon
https://read.qxmd.com/read/38396311/post-stroke-depression-in-older-adults-an-overview
#2
REVIEW
Fabio Giuseppe Masuccio, Erica Grange, Rachele Di Giovanni, Martina Rolla, Claudio Marcello Solaro
Detailed data on post-stroke depression (PSD) in older adults are limited in spite of the high vulnerability of this population to stroke. In fact, PSD prevalence in older adults ranges from 16.0 to 43.9%; however, timing and instruments of evaluation often differ significantly across all available studies. The etiology, genetic and inflammatory factors, as well as structural brain alterations, are claimed as part of a multifaceted mechanism of action in PSD onset. Thus, the aim of this narrative review was to further elaborate on the prevalence, etiology, diagnosis, consequences and treatment of PSD in older adults...
February 23, 2024: Drugs & Aging
https://read.qxmd.com/read/38355299/chronic-treatment-with-serotonin-selective-reuptake-inhibitors-does-not-affect-regrowth-of-serotonin-axons-following-amphetamine-injury-in-the-mouse-forebrain
#3
JOURNAL ARTICLE
Haley N Janowitz, David J Linden
A current hypothesis to explain the limited recovery following brain and spinal cord trauma stems from the dogma that neurons in the mammalian central nervous system lack the ability to regenerate their axons after injury. Serotonin (5-HT) neurons in the adult brain are a notable exception in that they can slowly regrow their axons following chemical or mechanical lesions. This process of regrowth occurs without intervention over several months and results in anatomical recovery that approximates the preinjured state...
February 2024: ENeuro
https://read.qxmd.com/read/38170802/a-comprehensive-overview-of-post-stroke-depression-treatment-options
#4
JOURNAL ARTICLE
Alberto Raggi, Alessandro Serretti, Raffaele Ferri
Nearly one-third of all stroke patients develop depression at any time after a stroke, and its presence is associated with unfavorable outcomes. This narrative review aims to provide a synopsis of possible pharmacological and non-pharmacological treatment modalities for post-stroke depression (PSD). Several studies have demonstrated the efficacy and safety of selective serotonin reuptake inhibitors in treating the symptoms of this clinical condition. The treatment of PSD has been recently enhanced by innovative approaches, such as cognitive-behavioral therapy, virtual reality, telehealth, repetitive transcranial magnetic stimulation, and non-conventional therapies, which might improve depression treatment in stroke survivors...
December 27, 2023: International Clinical Psychopharmacology
https://read.qxmd.com/read/38098127/emotional-dysmetria-after-cerebellar-pontine-stroke-a-case-report
#5
JOURNAL ARTICLE
Rebecca M Long, Michèle DuVal, Bridget Mulvany-Robbins, Amanda N Wagner, Glen C Jickling
INTRODUCTION: Pseudobulbar affect, or emotional dysregulation, commonly occurs following stroke. However, it is frequently missed in cases involving the cerebellum, resulting in a lack of treatment, which can directly impact stroke rehabilitation. CASE PRESENTATION: A 63-year-old Caucasian female with no history of mood disorders presented with gait instability, dysarthria, and right sided hemiplegia, secondary to cerebellar and pontine ischemic stroke from a basilar occlusion...
December 15, 2023: Journal of Medical Case Reports
https://read.qxmd.com/read/38020612/mechanisms-associated-with-post-stroke-depression-and-pharmacologic-therapy
#6
REVIEW
Qingyang Zhan, Fanyi Kong
Stroke is one of the most common cerebrovascular diseases, which is the cause of long-term mental illness and physical disability, Post-stroke depression (PSD) is the most common neuropsychiatric complication after stroke, and its mechanisms are characterized by complexity, plurality, and diversity, which seriously affects the quality of survival and prognosis of patients. Studies have focused on and recognized neurotransmitter-based mechanisms and selective serotonin-reuptake inhibitors (SSRIs) can be used to treat PSD...
2023: Frontiers in Neurology
https://read.qxmd.com/read/37854727/the-100-most-cited-kluver-bucy-research-articles-a-bibliometric-analysis
#7
REVIEW
Cynthia Janku, Priya V Engel, Kisan Patel, Elias Giraldo
Kluver-Bucy Syndrome (KBS) is a rare neuropsychiatric disorder characterized by hyperorality, hypersexuality, bulimia, visual agnosia, and amnesia due to lesions affecting bilateral temporal lobes. It is attributed to a multitude of causes, including stroke, herpes simplex encephalitis, Alzheimer's disease, and head trauma. Current treatments for KBS include symptomatic management with antipsychotics, mood stabilizers, carbamazepine, and selective serotonin reuptake inhibitors. The bibliometric analysis was done to reflect the relevance and understanding of KBS in recent literature...
September 2023: Curēus
https://read.qxmd.com/read/37572601/a-systematic-review-and-evaluation-of-post-stroke-depression-clinical-practice-guidelines
#8
JOURNAL ARTICLE
James Graham Cross, Brandon R May, Peter Q M Mai, Elizabeth Anderson, Connor Welsh, Shaeker Chandran, Kevin T Chorath, Shelby Herr, Daniel Gonzalez
OBJECTIVE: Post-stroke depression is a depressive mood disorder that follows a cerebrovascular accident and is a burden on stroke patients. Its management is included in clinical practice guidelines focused on stroke, and the recommended treatment is selective serotonin reuptake inhibitors in conjunction with psychotherapy. Clinical practice guidelines are recommendations used to standardize best medical practice, but there is no current evaluation of guidelines containing post stroke depression recommendations...
September 2023: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://read.qxmd.com/read/37559511/poststroke-depression-an-update
#9
JOURNAL ARTICLE
Robert G Robinson, Ricardo E Jorge, Sergio E Starkstein
The presence of neuropsychiatric disorders after stroke has been recognized for more than 100 years, but controlled systematic studies did not begin until the 1970s. The most clinically important advances, however, have been in the treatment and prevention of poststroke depression (PSD). Recent meta-analyses of randomized controlled trials (RCTs) for the treatment of PSD have demonstrated the efficacy of antidepressants. Similarly, RCTs for the prevention of PSD have shown that antidepressants significantly decrease the incidence of PSD compared with placebo...
August 10, 2023: Journal of Neuropsychiatry and Clinical Neurosciences
https://read.qxmd.com/read/37521479/herbal-medicine-as-adjunctive-therapy-with-antidepressants-for-post-stroke-depression-a-systematic-review-and-network-meta-analysis-of-randomized-controlled-trials
#10
Jian Zhang, Shuping Ming, Xiaoming Chen, Teng Zhang, Hongyu Qian, Shixiong Peng, Yanbing Ding
Background: Herbal medicine can provide adjunctive therapy for adults with post-stroke depression. This study summarizes the latest evidence regarding the harms and benefits of herbal antidepressants. Methods: The literature searched from the Cochrane Library (using the OVID platform), Embase, PubMed, the China National Knowledge Infrastructure (CNKI), the Wan Fang Data Knowledge Service Platform, and the China Scientific Journal Database (VIP) from their inception to 18 August 2021, for randomized controlled trials of herbal medicine in adults with post-stroke depression, were included in this systematic review and network meta-analysis...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/37485701/a-marginal-structural-model-to-estimate-the-effect-of-antidepressant-medication-treatment-on-major-cardiovascular-events-among-people-with-post-traumatic-stress-disorder
#11
JOURNAL ARTICLE
Kwanghyun Kim, Sunghyuk Kang, Chung Mo Nam, Robert Stewart, Alexander C Tsai, Sun Jae Jung
BACKGROUND: Previous evidence on antidepressant medication and cardiovascular disease (CVD) among patients with posttraumatic stress disorder (PTSD) has been inconclusive. We estimated the association between antidepressant medication and CVD by applying a marginal structural model. METHODS: We analyzed medical utilization records of 27 170 people with PTSD without prior major cardiovascular events in the Korean National Health Insurance Database (NHID). PTSD and CVD were defined in accordance with the recorded ICD-10 diagnostic codes...
July 24, 2023: Psychological Medicine
https://read.qxmd.com/read/37417988/dapoxetine-prevents-neuronal-damage-and-improves-functional-outcomes-in-a-model-of-ischemic-stroke-through-the-modulation-of-inflammation-and-oxidative-stress
#12
JOURNAL ARTICLE
Sarah Sameh Abdel-Hameed, Mahmoud El-Daly, Al-Shaimaa F Ahmed, Amany A Bekhit, Gehan H Heeba
Stroke is a medical emergency that is associated with substantial mortality and functional disability in adults. The most popular class of antidepressants, selective serotonin reuptake inhibitors SSRIs, have recently been shown in studies to have positive effects on post-stroke motor and cognitive function. Thus, we hypothesized that dapoxetine (DAP), a short-acting SSRI, would be effective against cerebral ischemia/reperfusion injury. Adult male Wister rats (200-250 g) were subjected to a sham operation or bilateral common carotid artery occlusion (BCCAO) for 30 min followed by 24 h of reperfusion to induce global cerebral ischemia/reperfusion (I/R) injury...
July 7, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
https://read.qxmd.com/read/37395333/stroke-depression-and-self-harm-in-later-life
#13
JOURNAL ARTICLE
Osvaldo P Almeida
PURPOSE OF THE REVIEW: To examine recently published results of randomized placebo-controlled trials investigating the clinical effects of selective serotonin reuptake inhibitors on the prevalence of clinically significant symptoms of depression and suicidal ideation after an acute stroke. RECENT FINDINGS: The prevalence of poststroke depression varies markedly according to the approach used to define depression, with recently published data suggesting that about one in every three stroke survivors will experience clinically significant symptoms of depression over a period of 12 months...
June 1, 2023: Current Opinion in Psychiatry
https://read.qxmd.com/read/37271792/supporting-post-stroke-language-and-cognition-with-pharmacotherapy-tools-for-each-phase-of-care
#14
REVIEW
Melissa D Stockbridge, Zafer Keser
PURPOSE OF REVIEW: There is enormous enthusiasm for the possibility of pharmacotherapies to treat language deficits that can arise after stroke. Speech language therapy remains the most frequently utilized and most strongly evidenced treatment, but the numerous barriers to patients receiving the therapy necessary to recover have motivated the creation of a relatively modest, yet highly cited, body of evidence to support the use of pharmacotherapy to treat post-stroke aphasia directly or to augment traditional post-stroke aphasia treatment...
June 5, 2023: Current Neurology and Neuroscience Reports
https://read.qxmd.com/read/37205743/effect-of-selective-serotonin-reuptake-inhibitors-on-motor-recovery-after-stroke-a-systematic-meta-analysis
#15
JOURNAL ARTICLE
Ju Sun Oh, Yoo Jin Choo, Min Cheol Chang
OBJECTIVE: We conducted a meta-analysis to determine the effectiveness of selective serotonin reuptake inhibitors in improving motor outcomes after stroke. For accuracy, we only included studies in which selective serotonin reuptake inhibitors were administered to patients in the recovery phase after stroke (<6 mos after stroke). DESIGN: Meta-analyses were conducted according to the tools used to measure motor function. We searched the SCOPUS, PubMed, Embase, and Cochrane Library databases for studies, which compared motor recovery in patients who receive selective serotonin reuptake inhibitor medication in the recovery phase after stroke with a control group that did not receive any selective serotonin reuptake inhibitor...
December 1, 2023: American Journal of Physical Medicine & Rehabilitation
https://read.qxmd.com/read/37199575/post-stroke-neuropsychiatric-complications-types-pathogenesis-and-therapeutic-intervention
#16
REVIEW
Jing Zhou, Yijia Fangma, Zhong Chen, Yanrong Zheng
Almost all stroke survivors suffer physical disabilities and neuropsychiatric disturbances, which can be briefly divided into post-stroke neurological diseases and post-stroke psychiatric disorders. The former type mainly includes post-stroke pain, post-stroke epilepsy, and post-stroke dementia while the latter one includes post-stroke depression, post-stroke anxiety, post-stroke apathy and post-stroke fatigue. Multiple risk factors are related to these post-stroke neuropsychiatric complications, such as age, gender, lifestyle, stroke type, medication, lesion location, and comorbidities...
March 13, 2023: Aging and Disease
https://read.qxmd.com/read/37081168/the-efficacy-and-safety-of-fluoxetine-versus-placebo-for-stroke-recovery-a-meta-analysis-of-randomized-controlled-trials
#17
REVIEW
Jixiang Wu, Guoyong Qin
BACKGROUND: Fluoxetine is one of the selective serotonin reuptake inhibitors that can improve motor and function recovery after a stroke. Several randomized controlled trials (RCTs) have investigated the efficacy and safety of fluoxetine compared to placebo in post-stroke recovery. However, the results are still controversial. AIM: This meta-analysis aimed to provide an updated analysis of the efficacy and safety of fluoxetine versus placebo in post-stroke recovery...
April 20, 2023: International Journal of Clinical Pharmacy
https://read.qxmd.com/read/37054418/top-20-research-studies-of-2022-for-primary-care-physicians
#18
JOURNAL ARTICLE
Roland Grad, Mark H Ebell
This article summarizes the top 20 research studies of 2022 identified as POEMs (patient-oriented evidence that matters), excluding COVID-19. Statins for primary prevention of cardiovascular disease produce only a small absolute reduction in a person's likelihood of dying (0.6%), having a myocardial infarction (0.7%), or having a stroke (0.3%) over three to six years. Supplemental vitamin D does not reduce the risk of a fragility fracture, even in people with low baseline vitamin D levels or a previous fracture...
April 2023: American Family Physician
https://read.qxmd.com/read/37041905/predictive-factors-and-interventional-modalities-of-post-stroke-motor-recovery-an-overview
#19
REVIEW
Ahmad S Badawi, Ghazi H Mogharbel, Sultan A Aljohani, Amal M Surrati
Stroke is the most common cause of motor impairment worldwide. Therefore, many factors are being investigated for their predictive and facilitatory effects on recovery of motor function after stroke. Motor recovery can be predicted through several factors, such as clinical assessment, clinical biomarkers, and gene-based variations. As for interventions, many methods are under experimental investigation that aim to improve motor recovery, including different types of pharmacological interventions, non-invasive stimulation, and rehabilitation training by inducing cortical reorganization, neuroplasticity, angiogenesis, changing the levels of neurotransmitters in the brain, and altering the inflammatory and apoptotic processes occurring after stroke...
March 2023: Curēus
https://read.qxmd.com/read/36973083/evaluating-the-link-between-self-reported-endometriosis-and-female-sexual-dysfunction
#20
JOURNAL ARTICLE
Juliana M Kling, Summer Ghaith, Taryn Smith, Ekta Kapoor, Megan Wasson, Kristin Mara, Felicity T Enders, Stephanie Faubion, Carol Kuhle
BACKGROUND: Studies have found that women with endometriosis have a higher risk of female sexual dysfunction (FSD). AIM: To evaluate the relationship between self-reported endometriosis and FSD utilizing validated surveys. METHODS: A cross-sectional analysis was conducted among sexually active women aged 18-90 who presented to 3 Mayo Clinic sites from 2015 to 2021. FSD was determined utilizing a combined endpoint of Female Sexual Function Index score ≤ 26...
October 1, 2022: Journal of Sexual Medicine
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