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https://www.readbyqxmd.com/read/27871966/improvement-in-compensation-for-chronic-post-stroke-homonymous-hemianopsia-following-initiation-of-an-ssri-a-case-report
#1
Benjamin A Abramoff, S Byron Milton, Samir R Belagaje
Homonymous hemianopsia (HH) is a common adverse outcome following stroke. Spontaneous improvement more than 6 months post stroke is thought to be unlikely, and traditional visual rehabilitation techniques lack clear evidence of efficacy. The case presented is of a 22 year-old woman who demonstrated improved compensation of her stroke-induced HH following the initiation of a selective serotonin reuptake inhibitor (SSRI). There is evidence supporting the use of SSRIs to improve post-stroke cognitive impairment, motor impairment and depression...
November 18, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27673040/poster-283-improvement-in-compensation-for-chronic-post-stroke-homonymous-hemianopsia-following-initiation-of-an-ssri-a-case-report
#2
Benjamin A Abramoff, Samir Belagaje, Samuel Milton
No abstract text is available yet for this article.
September 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27612144/use-of-selective-serotonin-reuptake-inhibitors-and-risks-of-stroke-in-patients-with-obsessive-compulsive-disorder-a-population-based-study
#3
Che-Sheng Chu, Po-Han Chou, Ching-Heng Lin, Chin Cheng, Chia-Jui Tsai, Tsuo-Hung Lan, Min-Wei Huang, Gerald Nestadt
BACKGROUND: Previous research has suggested a link between antidepressants use and the development of cerebrovascular events, but there has never been any study investigating the risk of stroke in obsessive-compulsive disorder (OCD) patients treated with a selective serotonin reuptake inhibitor (SSRI). METHODS: A retrospective observational cohort study was conducted using data from the National Health Insurance Database of Taiwan between the year of 2001 and 2009...
2016: PloS One
https://www.readbyqxmd.com/read/27536109/post-stroke-emotional-incontinence-or-bipolar-disorder
#4
Leila Mnif, Rim Sellami, Jawaher Masmoudi
INTRODUCTION: Post-stroke emotional incontinence and bipolar disorder are two disorders that involve the dysfunction of brain structures responsible for emotional regulation. The objective of this work is to study the links between these disorders through a clinical case. CASE REPORT: We present the case of a 43-year-old man without previous psychiatric history who experienced emotional incontinence after cerebrovascular events. He reacted promptly to selective serotonin reuptake inhibitor treatment...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27150152/effects-of-adjuvant-analgesics-on-cerebral-ischemia-induced-mechanical-allodynia
#5
Wataru Matsuura, Shinichi Harada, Shogo Tokuyama
Central post-stroke pain (CPSP), a potential sequela of stroke, is classified as neuropathic pain. Although we recently established a CPSP-like model in mice, the effects of adjuvant analgesics as therapeutic drugs for neuropathic pain in this model are unknown. Hence, the aim of the present study was to assess the usefulness of our model by evaluating the effects of adjuvant analgesics used for treating neuropathic pain in this mouse model of CPSP. Male ddY mice were subjected to 30 min of bilateral carotid artery occlusion (BCAO)...
2016: Biological & Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/27138221/preadmission-use-of-selective-serotonin-reuptake-inhibitors-and-short-term-mortality-in-diabetic-patients-hospitalized-due-to-stroke
#6
M Würtz, M Schmidt, E L Grove, E Horváth-Puhó, C F Christiansen, H T Sørensen
BACKGROUND: Patients with diabetes have an increased risk of stroke with a poor prognosis. Moreover, diabetic patients are at increased risk of depression and therefore likely to use selective serotonin reuptake inhibitors (SSRIs). We examined whether preadmission SSRI use was associated with increased mortality in diabetic patients hospitalized due to stroke. METHODS: Population-based medical databases were used to identify all first-time stroke-related hospitalizations and subsequent mortality in diabetic patients in Denmark between 2004 and 2012 (n = 12 620)...
October 2016: Journal of Internal Medicine
https://www.readbyqxmd.com/read/27022963/risk-of-stroke-among-older-medicare-antidepressant-users-with-traumatic-brain-injury
#7
Bilal Khokhar, Linda Simoni-Wastila, Jennifer S Albrecht
OBJECTIVE: To estimate the risk of stroke associated with new antidepressant use among older adults with traumatic brain injury (TBI). PARTICIPANTS: A total of 64 214 Medicare beneficiaries aged 65 years or older meeting inclusion criteria and hospitalized with a TBI during 2006 to 2010. DESIGN: New user design. Generalized estimating equations were used to estimate the relative risks (RRs) of stroke. MAIN MEASURES: Primary exposure was new antidepressant use following TBI identified through Medicare part D claims...
March 28, 2016: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/27008002/persistence-with-antidepressant-drugs-in-patients-with-dementia-a-retrospective-database-analysis
#8
COMPARATIVE STUDY
Anke Booker, Jens Bohlken, Michael A Rapp, Karel Kostev
BACKGROUND: The aims of the present study are to determine what proportion of patients with dementia receives antidepressants, how long the treatment is administered, and what factors increase the risk of discontinuation. METHODS: The study was based on Disease Analyzer database and included 1,203 general practitioners (GP) and 209 neurologists/psychiatrists (NP). 12,281 patients with a diagnosis of dementia and an initial prescription of an antidepressant drug between January 2004 and December 2013 were included...
May 2016: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27005565/antidepressant-use-and-risk-of-cardiovascular-outcomes-in-people-aged-20-to-64-cohort-study-using-primary-care-database
#9
Carol Coupland, Trevor Hill, Richard Morriss, Michael Moore, Antony Arthur, Julia Hippisley-Cox
OBJECTIVE: To assess associations between different antidepressant treatments and rates of three cardiovascular outcomes (myocardial infarction, stroke or transient ischaemic attack, and arrhythmia) in people with depression. DESIGN: Cohort study. SETTING: UK general practices contributing to the QResearch primary care database. PARTICIPANTS: 238,963 patients aged 20 to 64 years with a first diagnosis of depression between 1 January 2000 and 31 July 2011...
2016: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/26976669/fluoxetine-protects-against-il-1%C3%AE-induced-neuronal-apoptosis-via-downregulation-of-p53
#10
Han Shan, Yaqi Bian, Zhaoma Shu, Linxia Zhang, Jialei Zhu, Jianhua Ding, Ming Lu, Ming Xiao, Gang Hu
Fluoxetine, a selective serotonin reuptake inhibitor, exerts neuroprotective effects in a variety of neurological diseases including stroke, but the underlying mechanism remains obscure. In the present study, we addressed the molecular events in fluoxetine against ischemia/reperfusion-induced acute neuronal injury and inflammation-induced neuronal apoptosis. We showed that treatment of fluoxetine (40 mg/kg, i.p.) with twice injections at 1 h and 12 h after transient middle cerebral artery occlusion (tMCAO) respectively alleviated neurological deficits and neuronal apoptosis in a mouse ischemic stroke model, accompanied by inhibiting interleukin-1β (IL-1β), Bax and p53 expression and upregulating anti-apoptotic protein Bcl-2 level...
August 2016: Neuropharmacology
https://www.readbyqxmd.com/read/26845272/comparison-of-the-effects-of-serotonin-norepinephrine-reuptake-inhibitors-versus-selective-serotonin-reuptake-inhibitors-on-cerebrovascular-events
#11
COMPARATIVE STUDY
Yen-Chieh Lee, Chin-Hsien Lin, Min-Shung Lin, Yun Lu, Chia-Hsuin Chang, Jou-Wei Lin
BACKGROUND: Use of selective serotonin reuptake inhibitors (SSRIs) has been associated with an increased risk of intracranial hemorrhage. However, little is known about cerebrovascular risk in users of serotonin-norepinephrine reuptake inhibitors (SNRIs). Our aim was to determine the differential risk of cerebrovascular events between SSRIs and SNRIs. METHOD: A nationwide population-based cohort study was conducted in adult patients who started taking SSRIs or SNRIs during the time period 2005 through 2009...
January 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/26845268/antidepressant-treatment-and-risk-of-dementia-a-population-based-retrospective-case-control-study
#12
Cynthia Wei-Sheng Lee, Cheng-Li Lin, Fung-Chang Sung, Ji-An Liang, Chia-Hung Kao
OBJECTIVE: We investigated the relationship between antidepressant use and the risk of subsequent dementia development. METHOD: A population-based retrospective case-control analysis was conducted using the Taiwan National Health Insurance Research Database. From patients enrolled in the National Health Insurance program between 2005 and 2011, we identified 2 subsets: 5,394 cases, who had major depression in 1997-2004 and subsequently were diagnosed with dementia (ICD-9-CM code 290) in 2005-2011, and 5,232 controls, who had major depression in 2005-2011 but no dementia history...
January 2016: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/26807800/reversible-cerebral-vasoconstriction-syndrome-presenting-with-visual-field-defects
#13
Meisha L Raven, Alexander L Ringeisen, Angela R McAllister, Daniel W Knoch
A 45-year-old woman with a history of depression and anxiety, treated with selective serotonin reuptake inhibitors (SSRIs), experienced acute, recurrent, and severe bifrontal headaches. Over time, she developed a left homonymous hemianopia and mental status changes. MRA revealed segmental vasoconstriction of cerebral arteries in multiple vascular distributions. She was treated with a calcium-channel blocker and magnesium, and there was resolution of her symptoms and cerebrovascular changes. Her clinical course and neuroimaging findings were consistent with reversible cerebral vasoconstriction syndrome...
June 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
https://www.readbyqxmd.com/read/26803777/the-natural-history-of-depression-and-trajectories-of-symptoms-long-term-after-stroke-the-prospective-south-london-stroke-register
#14
Salma A Ayis, Luis Ayerbe, Siobhan L Crichton, Anthony G Rudd, Charles D A Wolfe
BACKGROUND: The natural history of depression in stroke patients is complex and the mechanism of change in symptoms over time is not fully understood. We hypothesise that there are different trajectories of symptoms after stroke. METHODS: The primary analysis comprised 761 patients who completed 5 years follow up, obtained from the prospective South London Stroke Register (1998-2013). The Hospital Anxiety and Depression scale (HADs) was used to screen patients for depression symptoms at 3 months after stroke, then annually...
April 2016: Journal of Affective Disorders
https://www.readbyqxmd.com/read/26783360/antidepressant-medication-use-and-its-association-with-cardiovascular-disease-and-all-cause-mortality-in-the-reasons-for-geographic-and-racial-differences-in-stroke-regards-study
#15
Richard A Hansen, Yulia Khodneva, Stephen P Glasser, Jingjing Qian, Nicole Redmond, Monika M Safford
BACKGROUND: Mixed evidence suggests that second-generation antidepressants may increase the risk of cardiovascular and cerebrovascular events. OBJECTIVE: To assess whether antidepressant use is associated with acute coronary heart disease (CHD), stroke, cardiovascular disease (CVD) death, and all-cause mortality. METHODS: Secondary analyses of the Reasons for Geographic and Racial Differences in Stroke (REGARDS) longitudinal cohort study were conducted...
April 2016: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/26559658/efficacy-and-safety-of-citalopram-in-treating-post-stroke-depression-a-meta-analysis
#16
Shuai Tan, Xinyi Huang, Lei Ding, Hua Hong
BACKGROUND AND PURPOSE: To evaluate the citalopram in post-stroke depression treatment, we compared its use to other selective serotonin reuptake inhibitors (SSRIs), tricyclic antidepressants (TCAs), and traditional Chinese medicines (TCMs). METHODS: We searched databases up to May 2015. Relative risk (RR) for dichotomous data and standard mean difference (SMD) for continuous variables were analyzed using Stata 13.1. RESULTS: The RR of the efficacy index compared to TCAs was 1...
2015: European Neurology
https://www.readbyqxmd.com/read/26522905/neuropharmacology-of-poststroke-motor-and-speech-recovery
#17
REVIEW
Zafer Keser, Gerard E Francisco
Almost 7 million adult Americans have had a stroke. There is a growing need for more effective treatment options as add-ons to conventional therapies. This article summarizes the published literature for pharmacologic agents used for the enhancement of motor and speech recovery after stroke. Amphetamine, levodopa, selective serotonin reuptake inhibitors, and piracetam were the most commonly used drugs. Pharmacologic augmentation of stroke motor and speech recovery seems promising but systematic, adequately powered, randomized, and double-blind clinical trials are needed...
November 2015: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/26516608/selective-serotonin-reuptake-inhibitors-to-improve-outcome-in-acute-ischemic-stroke-possible-mechanisms-and-clinical-evidence
#18
REVIEW
Timo Siepmann, Ana Isabel Penzlin, Jessica Kepplinger, Ben Min-Woo Illigens, Kerstin Weidner, Heinz Reichmann, Kristian Barlinn
BACKGROUND: Several clinical studies have indicated that selective serotonin reuptake inhibitors (SSRIs) administered in patients after acute ischemic stroke can improve clinical recovery independently of depression. Due to small sample sizes and heterogeneous study designs interpretability was limited in these studies. The mechanisms of action whereby SSRI might improve recovery from acute ischemic stroke are not fully elucidated. METHODS: We searched MEDLINE using the PubMed interface to identify evidence of SSRI mediated improvement of recovery from acute ischemic stroke and reviewed the literature on the potential underlying mechanisms of action...
October 2015: Brain and Behavior
https://www.readbyqxmd.com/read/26447123/explanatory-factors-for-the-association-between-depression-and-long-term-physical-disability-after-stroke
#19
Luis Ayerbe, Salma A Ayis, Siobhan Crichton, Anthony G Rudd, Charles D A Wolfe
OBJECTIVES: To identify explanatory factors for the association between depression at 3 months after stroke and physical disability at 3 years. METHODS: Data from the South London Stroke Register (1998-2013) were used. Patients (n = 3,612) were assessed at stroke onset. Follow-up at 3 months included assessment for depression with the Hospital Anxiety and Depression scale (scores ≥ 7 = depression), physical disability (Barthel index) cognitive function, smoking habit, selective serotonin reuptake inhibitors (SSRIs) use, perception of recovery and social support...
November 2015: Age and Ageing
https://www.readbyqxmd.com/read/26376447/increased-lower-limb-spasticity-but-not-strength-or-function-following-a-single-dose-serotonin-reuptake-inhibitor-in-chronic-stroke
#20
RANDOMIZED CONTROLLED TRIAL
Krishnaj Gourab, Brian D Schmit, T George Hornby
OBJECTIVE: To investigate the effects of single doses of a selective serotonin reuptake inhibitor (SSRI) on lower limb voluntary and reflex function in individuals with chronic stroke. DESIGN: Double-blind, randomized, placebo-controlled crossover trial. SETTING: Outpatient research setting. PARTICIPANTS: Individuals (N=10; 7 men; mean age ± SD, 57±10y) with poststroke hemiplegia of >1 year duration who completed all assessments...
December 2015: Archives of Physical Medicine and Rehabilitation
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