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https://www.readbyqxmd.com/read/29443835/venous-thromboembolism-incidence-after-craniofacial-surgery
#1
Wilson I Omesiete, James A Walker, Jack C Yu
INTRODUCTION: Current protocols for venous thromboembolism (VTE) prophylaxis after craniofacial surgery (CFS) vary widely with substantial disagreements in both indications and managements. An evidence-based approach to this issue requires the following: the incidence of postoperative VTE, comorbidities associated with coagulopathy, risk reduction after VTE prophylaxis, and complications attributable to prophylaxis. This study addresses the first two. DESIGN: Retrospective cross-sectional study...
February 13, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29439831/routine-invasive-versus-selective-invasive-strategy-in-elderly-patients-older-than-75-years-with-non-st-segment-elevation-acute-coronary-syndrome-a-systematic-review-and-meta-analysis
#2
Aakash Garg, Lohit Garg, Manyoo Agarwal, Amit Rout, Hitesh Raheja, Sahil Agrawal, Sunil V Rao, Marc Cohen
OBJECTIVE: To evaluate outcomes of routine invasive strategy (RIS) compared with selective invasive strategy (SIS) in elderly patients older than 75 years with non-ST-segment elevation acute coronary syndrome (NSTE-ACS). METHODS: We systematically searched databases for randomized controlled trials (RCTs) between January 1, 1990, and October 1, 2016, comparing RIS with SIS for elderly patients (age>75 years) with NSTE-ACS. Random effects meta-analysis was conducted to estimate odds ratio (OR) with 95% CIs for composite of death or myocardial infarction (MI), and individual end points of all-cause death, cardiovascular (CV) death, MI, revascularization, and major bleeding...
February 10, 2018: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/29438530/hypertrophic-obstructive-cardiomyopathy-what-when-why-for-whom
#3
Carlos A Mestres, Thomas Bartel, Antonio Sorgente, Silvana Müller, Christiane Gruner, Joseph Dearani, Eduard Quintana
Hypertrophic cardiomyopathy is the most common genetic cardiovascular disorder and is associated with symptoms of heart failure and increased risk of sudden cardiac death. The most common condition is obstruction of the left ventricular outflow tract. Surgical septal myectomy and alcohol septal ablation are the 2 accepted modes of septal reduction therapy and are indicated when there are advanced symptoms and a peak left ventricular outflow gradient ≥50 mmHg. Advantages of alcohol septal ablation are limited groin approach, reduction of obstruction of the left ventricular outflow tract and functional improvement, but there are higher chances for intracardiac device implantation and residual obstruction...
February 9, 2018: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29438454/comparative-efficacy-of-antihypertensive-agents-in-salt-sensitive-hypertensive-patients-a-network-meta-analysis
#4
Han Qi, Zheng Liu, Han Cao, Wei-Ping Sun, Wen-Juan Peng, Bin Liu, Sheng-Jie Dong, Yu-Tao Xiang, Ling Zhang
Background: Salt-sensitive hypertension (SSH) is an intermediate inherited phenotype of essential hypertension as well as being an independent risk factor for cardiovascular disease. However, effective medications for the treatment of SSH have not been clarified. This study was to compare the efficacious of different classes of antihypertensive agents combined with salt intake on the reduction of blood pressure in patients with salt-sensitive hypertension (SSH). Methods: We used sources as PubMed, EMBASE, Cochrane Library, CENTRAL, ClinicalTrials...
February 9, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29437574/csl112-apolipoprotein-a-i-human-enhances-cholesterol-efflux-similarly-in-healthy-individuals-and-stable-atherosclerotic-disease-patients
#5
Andreas Gille, Denise D'Andrea, Michael A Tortorici, Gunter Hartel, Samuel D Wright
OBJECTIVE: CSL112 (apolipoprotein A-I [apoA-I; human]) is a novel formulation of apoA-I in development for reduction of early recurrent cardiovascular events after acute myocardial infarction. Cholesterol efflux capacity (CEC) is a marker of high-density lipoprotein (HDL) function that is strongly correlated with incident cardiovascular disease. Impaired CEC has been observed in patients with coronary heart disease. Here, we determined whether infused apoA-I improves CEC when administered to patients with stable atherosclerotic disease versus healthy volunteers...
February 8, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29435776/effect-of-anagliptin-and-sitagliptin-on-low-density-lipoprotein-cholesterol-in-type-2-diabetic-patients-with-dyslipidemia-and-cardiovascular-risk-rationale-and-study-design-of-the-reason-trial
#6
Shinichiro Ueda, Michio Shimabukuro, Osamu Arasaki, Koichi Node, Takashi Nomiyama, Takeshi Morimoto
BACKGROUND: Reduction of low-density lipoprotein cholesterol (LDL-C) is important for patients with a high risk for atherosclerotic events, such as patients with diabetes and other risk factors. Anagliptin was reported to reduce LDL-C for 12 weeks in phase III trials regardless of the use of statins, but it is uncertain whether this effect is common to other dipeptidylpeptidase-4 (DPP-4) inhibitors. METHODS: A multicenter, randomized, open-label, parallel-group trial was conducted to confirm the superiority of anagliptin to sitagliptin in terms of the primary endpoint of reduction of LDL-C for 52 weeks in patients with type 2 diabetes and atherosclerotic vascular lesions, as well as the non-inferiority of anagliptin to sitagliptin in terms of change in hemoglobin A1c (HbA1c)...
February 12, 2018: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/29434314/elevated-circulating-levels-of-succinate-in-human-obesity-are-linked-to-specific-gut-microbiota
#7
Carolina Serena, Victoria Ceperuelo-Mallafré, Noelia Keiran, Maria Isabel Queipo-Ortuño, Rosa Bernal, Ricardo Gomez-Huelgas, Mireia Urpi-Sarda, Mónica Sabater, Vicente Pérez-Brocal, Cristina Andrés-Lacueva, Andres Moya, Francisco J Tinahones, Jose Manuel Fernández-Real, Joan Vendrell, Sonia Fernández-Veledo
Gut microbiota-related metabolites are potential clinical biomarkers for cardiovascular disease (CVD). Circulating succinate, a metabolite produced by both microbiota and the host, is increased in hypertension, ischemic heart disease, and type 2 diabetes. We aimed to analyze systemic levels of succinate in obesity, a major risk factor for CVD, and its relationship with gut microbiome. We explored the association of circulating succinate with specific metagenomic signatures in cross-sectional and prospective cohorts of Caucasian Spanish subjects...
February 12, 2018: ISME Journal
https://www.readbyqxmd.com/read/29432589/changing-change-adaptations-of-an-evidence-based-telehealth-cardiovascular-disease-risk-reduction-intervention
#8
Leah L Zullig, Felicia McCant, Mina Silberberg, Fred Johnson, Bradi B Granger, Hayden B Bosworth
Relatively few successful medication adherence interventions are translated into real-world clinical settings. The Prevention of Cardiovascular Outcomes in African Americans with Diabetes (CHANGE) intervention was originally conceived as a randomized controlled trial to improve cardiovascular disease-related medication adherence and health outcomes. The purpose of the study was to describe the translation of the CHANGE trial into two community-based clinical programs. CHANGE 2 was available to Medicaid patients with diabetes and hypertension whose primary care homes were part of a care management network in the Northern Piedmont region of North Carolina...
February 8, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29431526/the-potential-role-of-statins-in-treating-liver-disease
#9
Konstantinos P Imprialos, Konstantinos Stavropoulos, Michael Doumas, Anastasia Skalkou, Ioanna Zografou, Vasilios G Athyros
Statins are commonly use for the management of dyslipidemia, worldwide. Various studies have demonstrated that statins offer significant reduction in the risk of cardiovascular morbidity and mortality. However, this class of drugs has been implicated in potential liver toxicity, thus has been considered as a "forbidden-drug" in patients with increased liver enzymes. Areas covered: Studies have shown that statins might offer clinical benefits in the setting of viral hepatitis, progression of cirrhosis, and hepatocellular carcinoma...
February 12, 2018: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29428832/long-term-efficacy-and-safety-of-proprotein-convertase-subtilisin-kexin-9-monoclonal-antibodies-a-meta-analysis-of-11-randomized-controlled-trials
#10
REVIEW
Jie Bai, Li-Lin Gong, Qi-Fu Li, Zhi-Hong Wang
BACKGROUND: Monoclonal antibodies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9) have been shown to significantly reduce low-density lipoprotein cholesterol (LDL-C) levels. OBJECTIVE: The purpose of this study was to assess the long-term efficacy and safety of PCSK9 antibodies. METHODS: PubMed, EMBASE, the Cochrane Library, and ClinicalTrials.gov were searched for relevant studies. RESULTS: A total of 11 studies including 38,235 participants who were treated for at least 48 weeks were included in this meta-analysis...
January 12, 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29427606/recommending-flavanols-and-procyanidins-for-cardiovascular-health-revisited
#11
REVIEW
Javier I Ottaviani, Christian Heiss, Jeremy P Spencer, Malte Kelm, Hagen Schroeter
The last 8 years have seen significant developments in our understanding of dietary flavanols and procyanidins in the context of human health and nutrition. During the same time, recognition of the importance of nutrition in primary disease prevention and health maintenance has increased. In addition, the concept of dietary bioactives (food constituents that although not essential to human life and procreation, may nevertheless play an important role in disease risk reduction, primary disease prevention, and healthy aging) has been created and developed...
February 7, 2018: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29427465/mangifera-indica-l-extract-vimang%C3%A2-reduces-plasma-and-liver-cholesterol-and-leucocyte-oxidative-stress-in-hypercholesterolemic-ldl-receptor-deficient-mice
#12
Gabriel G Dorighello, Natália M Inada, Bruno A Paim, Gilberto L Pardo-Andreu, Anibal E Vercesi, Helena C F Oliveira
Cardiovascular diseases are major causes of death worldwide. Beyond the classical cholesterol risk factor, other conditions such as oxidative stress are well documented to promote atherosclerosis. The Mangifera indica L. extract (Vimang® ) was reported to present antioxidant and hypocholesterolemic properties. Thus, here we evaluate the effects of Vimang treatment on risk factors of the atherosclerosis prone model of familial hypercholesterolemia, the LDL receptor knockout mice. Mice were treated with Vimang during two weeks and were fed a cholesterol-enriched diet during the second week...
February 10, 2018: Cell Biology International
https://www.readbyqxmd.com/read/29424469/effect-of-intensive-blood-pressure-control-in-patients-with-type-2-diabetes-mellitus-over-9-years-of-follow-up-a-subgroup-analysis-of-high-risk-accordion-trial-participants
#13
Leo F Buckley, Dave L Dixon, George F Wohlford, Dayanjan S Wijesinghe, William L Baker, Benjamin W Van Tassell
Although guidelines recommend strict blood pressure (BP) control in patients with type 2 diabetes mellitus (T2DM) and elevated cardiovascular risk, the long-term effects of this approach are unknown. We investigated the effect of intensive BP control on clinical outcomes in patients with T2DM over 9 years of follow-up. We included ACCORD BP participants in the standard glucose control arm who had established cardiovascular disease, chronic kidney disease, age ≥75 years or 10-year coronary heart risk ≥15%...
February 9, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29423761/comparative-safety-and-efficacy-of-insulin-degludec-with-insulin-glargine-in-type-2-and-type-1-diabetes-a-meta-analysis-of-randomized-controlled-trials
#14
Xiao-Wen Zhang, Xin-Lin Zhang, Biao Xu, Li-Na Kang
AIMS: To determine the safety and efficacy of insulin degludec versus glargine in patients with type 1 (T1D) and type 2 (T2D) diabetes mellitus. METHODS: Databases were searched until July 5, 2017. We included randomized controlled trials comparing degludec with glargine in diabetic patients, each with a minimum of 16 weeks of follow-up. RESULTS: Eighteen trials with 16,791 patients were included. Degludec was associated with a statistically significant reduction in risk for all confirmed hypoglycemia at the maintenance treatment period [estimated rate ratio (ERR) 0...
February 8, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29423456/unraveling-mechanisms-of-toxicant-induced-oxidative-stress-in-cardiovascular-disease
#15
Tammy R Dugas
To date, numerous clinical studies examining correlations between oxidative stress biomarkers and cardiovascular diseases (CVD) have repeatedly suggested a role for oxidant injury in the pathogenesis of diseases such as atherosclerosis. Despite this, antioxidant supplementation trials have not demonstrated a reduction in disease progression. Nevertheless, small animal and epidemiological studies have linked exposures to certain toxicants with increased CVD risk involving putative oxidative stress mechanisms...
February 2018: Current Opinion in Toxicology
https://www.readbyqxmd.com/read/29422539/a-global-perspective-on-sulfur-oxide-controls-in-coal-fired-power-plants-and-cardiovascular-disease
#16
Cheng-Kuan Lin, Ro-Ting Lin, Pi-Cheng Chen, Pu Wang, Nathalie De Marcellis-Warin, Corwin Zigler, David C Christiani
Sulfur oxides (SOx), particularly SO2 emitted by coal-fired power plants, produce long-term risks for cardiovascular disease (CVD). We estimated the relative risks of CVD and ischemic heart disease (IHD) attributable to SOx emission globally. National SOx reduction achieved by emissions control systems was defined as the average SOx reduction percentage weighted by generating capacities of individual plants in a country. We analyzed the relative risk of CVD incidence associated with national SOx reduction for 13,581 coal-fired power-generating units in 79 countries...
February 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29421012/clinical-features-and-outcomes-of-patients-with-type-2-myocardial-infarction-insights-from-the-thrombin-receptor-antagonist-for-clinical-event-reduction-in-acute-coronary-syndrome-tracer-trial
#17
Patrícia O Guimarães, Sergio Leonardi, Zhen Huang, Lars Wallentin, Frans Van de Werf, Philip E Aylward, Claes Held, Robert A Harrington, David J Moliterno, Paul W Armstrong, Harvey D White, Karen P Alexander, Renato D Lopes, Kenneth W Mahaffey, Pierluigi Tricoci
BACKGROUND: Type 2 myocardial infarction (MI) is characterized by an imbalance between myocardial blood supply and demand, leading to myocardial ischemia without coronary plaque rupture, but its diagnosis is challenging. METHODS: In the TRACER trial, patients with non-ST-segment elevation acute coronary syndromes were included. We aimed to describe provoking factors, cardiac biomarker profiles, treatment patterns, and clinical outcomes of patients with type 2 MIs...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29421011/effect-of-adding-glp-1ra-on-mortality-cardiovascular-events-and-metabolic-outcomes-among-insulin-treated-patients-with-type-2-diabetes-a-large-retrospective-uk-cohort-study
#18
Uchenna Anyanwagu, Jil Mamza, Richard Donnelly, Iskandar Idris
BACKGROUND: Combining a GLP-1 receptor agonist (GLP-1RA) with insulin is often an effective treatment strategy for overweight patients with type 2 diabetes (T2D), but little is known about the longer-term effects on cardiovascular and mortality outcomes in routine clinical practice in the United Kingdom. We therefore compared the times to a major nonfatal cardiovascular (CV) event and all-cause mortality among overweight patients with T2D treated with insulin alone versus insulin+GLP-1RA in a large UK database...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29421002/evaluation-of-the-safety-and-efficacy-of-an-edoxaban-based-antithrombotic-regimen-in-patients-with-atrial-fibrillation-following-successful-percutaneous-coronary-intervention-pci-with-stent-placement-rationale-and-design-of-the-entrust-af-pci-trial
#19
Pascal Vranckx, Thorsten Lewalter, Marco Valgimigli, Jan G Tijssen, Paul-Egbert Reimitz, Lars Eckardt, Hans-Joachim Lanz, Wolfgang Zierhut, Rüdiger Smolnik, Andreas Goette
BACKGROUND: The optimal antithrombotic treatment after percutaneous coronary intervention (PCI) with stenting in patients with atrial fibrillation (AF) is unknown. In the ENGAGE AF-TIMI 48 trial, edoxaban was noninferior to a vitamin K antagonist (VKA) with respect to the prevention of stroke or systemic embolism and was associated with significantly lower rates of bleeding and cardiovascular death in patients with nonvalvular AF. The effects of edoxaban in combination with single- or dual-antiplatelet therapy in the setting of PCI are unexplored...
February 2018: American Heart Journal
https://www.readbyqxmd.com/read/29420964/metabolic-surgery-weight-loss-diabetes-and-beyond
#20
REVIEW
Manan Pareek, Philip R Schauer, Lee M Kaplan, Lawrence A Leiter, Francesco Rubino, Deepak L Bhatt
The alarming rise in the worldwide prevalence of obesity is paralleled by an increasing burden of type 2 diabetes mellitus. Metabolic surgery is the most effective means of obtaining substantial and durable weight loss in individuals with obesity. Randomized trials have recently shown the superiority of surgery over medical treatment alone in achieving improved glycemic control, as well as a reduction in cardiovascular risk factors. The mechanisms seem to extend beyond the magnitude of weight loss alone and include improvements in incretin profiles, insulin secretion, and insulin sensitivity...
February 13, 2018: Journal of the American College of Cardiology
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