keyword
https://read.qxmd.com/read/37304233/macrophage-derived-shp-2-inhibits-the-metastasis-of-colorectal-cancer-via-tie2-pi3k-signals
#1
JOURNAL ARTICLE
Xueliang Wu, Shaoyu Guan, Yonggang Lu, Jun Xue, Xiangyang Yu, Q I Zhang, Ximo Wang, Tian Li
This research aimed to explore the influence of Src homology-2 containing protein tyrosine phosphatase (SHP-2) on the functions of tyrosine kinase receptors with immunoglobulin and EGF homology domains 2 (Tie2)-expressing monocyte/macrophages (TEMs) and the influence of the angiopoietin(Ang)/Tie2-phosphatidylinositol-3-kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) (Ang/Tie2-PI3K/Akt/mTOR) signaling pathway on the tumor microvascular remodeling in an immunosuppressive microenvironment...
2023: Oncology Research
https://read.qxmd.com/read/36876965/expression-of-tie2-angiopoietin-receptor-on-the-monocyte-subpopulations-from-ischemic-stroke-patients-histological-and-flowcytometric-studies
#2
JOURNAL ARTICLE
Aziza R Alrafiah
INTRODUCTION: Different subpopulations of monocytes play roles in phagocytosis, inflammation, and angiogenic processes e.g., Tie2-expressing monocytes (TEMs). The brain is flooded with macrophages that are derived from monocytes within 3-7 days after a stroke. This study aimed to determine the expression level of Tie2 (an angiopoietin receptor) on monocytes and their subpopulations in ischemic stroke patients using the histological and immunohistological study of bone marrow biopsies and blood flow cytometry examination...
February 28, 2023: Histology and Histopathology
https://read.qxmd.com/read/36509928/characterization-of-circulating-immune-cells-and-correlation-with-tie2-angiopoietins-level-in-well-differentiated-neuroendocrine-gastroenteropancreatic-tumors-a-cross-sectional-analysis
#3
JOURNAL ARTICLE
F Sesti, G Puliani, T Feola, F Campolo, F Sciarra, V Hasenmajer, A Lenzi, A Faggiano, A M Isidori, M A Venneri, E Giannetta
PURPOSE: The immune environment represents a new, but little explored, tool for understanding neuroendocrine neoplasms (NENs) behavior. An immunosuppressed microenvironment is hypothesized to promote NENs progression. A missing profiling of circulating leukocyte and peripheral blood mononuclear cells (PBMCs) subpopulations would open new perspectives in the still limited diagnostic-therapeutic management of NENs. METHODS: A cross-sectional case-control pilot study was performed recruiting 30 consecutive subjects: 15 patients naïve to treatment, with histologically proven gastroenteropancreatic (GEP) neuroendocrine tumors (NETs) and 15 healthy controls, matched for age and sex...
December 12, 2022: Endocrine
https://read.qxmd.com/read/35737458/monocyte-proinflammatory-phenotypic-control-by-ephrin-type-a-receptor-4-mediates-neural-tissue-damage
#4
JOURNAL ARTICLE
Elizabeth A Kowalski, Eman Soliman, Colin Kelly, Erwin Kristobal Gudenschwager Basso, John Leonard, Kevin J Pridham, Jing Ju, Alison Cash, Amanda Hazy, Caroline de Jager, Alexandra M Kaloss, Hanzhang Ding, Raymundo D Hernandez, Gabe Coleman, Xia Wang, Michelle L Olsen, Alicia M Pickrell, Michelle H Theus
Circulating monocytes have emerged as key regulators of the neuroinflammatory milieu in a number of neuropathological disorders. Ephrin type A receptor 4 (Epha4) receptor tyrosine kinase, a prominent axon guidance molecule, has recently been implicated in the regulation of neuroinflammation. Using a mouse model of brain injury and a GFP BM chimeric approach, we found neuroprotection and a lack of significant motor deficits marked by reduced monocyte/macrophage cortical infiltration and an increased number of arginase-1+ cells in the absence of BM-derived Epha4...
August 8, 2022: JCI Insight
https://read.qxmd.com/read/35704597/sex-specific-effects-of-daily-tadalafil-on-diabetic-heart-kinetics-in-recogito-a-randomized-double-blind-placebo-controlled-trial
#5
RANDOMIZED CONTROLLED TRIAL
Riccardo Pofi, Elisa Giannetta, Tiziana Feola, Nicola Galea, Federica Barbagallo, Federica Campolo, Roberto Badagliacca, Biagio Barbano, Federica Ciolina, Giuseppe Defeudis, Tiziana Filardi, Franz Sesti, Marianna Minnetti, Carmine D Vizza, Patrizio Pasqualetti, Pierluigi Caboni, Iacopo Carbone, Marco Francone, Carlo Catalano, Paolo Pozzilli, Andrea Lenzi, Mary Anna Venneri, Daniele Gianfrilli, Andrea M Isidori
Cyclic GMP-phosphodiesterase type 5 (PDE5) inhibition has been shown to counteract maladaptive cardiac changes triggered by diabetes in some but not all studies. We performed a single-center, 20-week, double-blind, randomized, placebo-controlled trial (NCT01803828) to assess sex differences in cardiac remodeling after PDE5 inhibition in patients with diabetic cardiomyopathy. A total of 122 men and women (45 to 80 years) with long-duration (>3 years) and well-controlled type 2 diabetes mellitus (T2DM; HbA1c < 86 mmol/mol) were selected according to echocardiographic signs of cardiac remodeling...
June 15, 2022: Science Translational Medicine
https://read.qxmd.com/read/35549955/increased-frequency-of-proangiogenic-tunica-intima-endothelial-kinase-2-tie2-expressing-monocytes-in-individuals-with-type-2-diabetes-mellitus
#6
JOURNAL ARTICLE
M Reijrink, J van Ark, C P H Lexis, L M Visser, M E Lodewijk, I C C van der Horst, C J Zeebregts, H van Goor, S C A de Jager, G Pasterkamp, B H R Wolffenbuttel, J L Hillebrands
BACKGROUND: Individuals with type 2 diabetes mellitus (T2DM) have an increased risk for developing macrovascular disease (MVD) manifested by atherosclerosis. Phenotypically and functionally different monocyte subsets (classical; CD14++ CD16- , non-classical; CD14+ CD16++ , and intermediate; CD14++ CD16+ ) including pro-angiogenic monocytes expressing Tie2 (TEMs) can be identified. Here we investigated monocyte heterogeneity and its association with T2DM and MVD. METHODS: Individuals with (N = 51) and without (N = 56) T2DM were recruited and allocated to "non-MVD" or "with MVD" (i...
May 12, 2022: Cardiovascular Diabetology
https://read.qxmd.com/read/35373288/are-tems-canceled-questioning-the-functional-relevance-of-tie2-expressing-macrophages
#7
JOURNAL ARTICLE
Yuqing Zhang, Rolf A Brekken
Inflammatory cells are a vital component of the tumor stroma and, of these, tumor-associated macrophages (TAM) are the major cell type. TAMs are recruited early in tumorigenesis and generally promote metastasis, stimulate tumor angiogenesis, and drive immunosuppression. TAMs have been shown to express the endothelial cell markers that enable chemotaxis and proangiogenic capacity. In this issue of Cancer Research, Jakab and colleagues challenge the functional significance of Tie2-expressing monocytes/macrophages (TEM) in the context of tumor growth and progression...
April 1, 2022: Cancer Research
https://read.qxmd.com/read/34917096/endothelial-dysfunction-in-fabry-disease-is-related-to-glycocalyx-degradation
#8
JOURNAL ARTICLE
Solvey Pollmann, David Scharnetzki, Dominique Manikowski, Malte Lenders, Eva Brand
Fabry disease (FD) is an X-linked multisystemic lysosomal storage disease due to a deficiency of α-galactosidase A ( GLA /AGAL). Progressive cellular accumulation of the AGAL substrate globotriaosylceramide (Gb3 ) leads to endothelial dysfunction. Here, we analyzed endothelial function in vivo and in vitro in an AGAL-deficient genetic background to identify the processes underlying this small vessel disease. Arterial stiffness and endothelial function was prospectively measured in five males carrying GLA variants (control) and 22 FD patients under therapy...
2021: Frontiers in Immunology
https://read.qxmd.com/read/34459560/myeloid-cell-based-delivery-of-ifn-%C3%AE-reprograms-the-leukemia-microenvironment-and-induces-anti-tumoral-immune-responses
#9
JOURNAL ARTICLE
Adele Mucci, Gabriele Antonarelli, Carolina Caserta, Francesco Maria Vittoria, Giacomo Desantis, Riccardo Pagani, Beatrice Greco, Monica Casucci, Giulia Escobar, Laura Passerini, Nico Lachmann, Francesca Sanvito, Matteo Barcella, Ivan Merelli, Luigi Naldini, Bernhard Gentner
The immunosuppressive microenvironment surrounding tumor cells represents a key cause of treatment failure. Therefore, immunotherapies aimed at reprogramming the immune system have largely spread in the past years. We employed gene transfer into hematopoietic stem and progenitor cells to selectively express anti-tumoral cytokines in tumor-infiltrating monocytes/macrophages. We show that interferon-γ (IFN-γ) reduced tumor progression in mouse models of B-cell acute lymphoblastic leukemia (B-ALL) and colorectal carcinoma (MC38)...
October 7, 2021: EMBO Molecular Medicine
https://read.qxmd.com/read/34198760/prognostic-value-of-tie2-expressing-monocytes-in-chronic-lymphocytic-leukemia-patients
#10
JOURNAL ARTICLE
Justyna Woś, Sylwia Chocholska, Wioleta Kowalska, Waldemar Tomczak, Agata Szymańska, Agnieszka Karczmarczyk, Agnieszka Szuster-Ciesielska, Agnieszka Wojciechowska, Agnieszka Bojarska-Junak
Tie2-expressing monocytes (TEMs) are associated with tumor progression and metastasis. This unique subset of monocytes has been identified as a potential prognostic marker in several solid tumors. However, TEMs remain poorly characterized in hematological cancers, including chronic lymphocytic leukemia (CLL). This study analyzed, for the first time, the clinical significance of TEM population in CLL patients. Flow cytometry analysis of TEMs (defined as CD14+ CD16+ Tie2+ cells) was performed at the time of diagnosis on peripheral blood mononuclear cells from 104 untreated CLL patients...
June 5, 2021: Cancers
https://read.qxmd.com/read/33719571/machine-perfused-donor-kidneys-as-a-source-of-human-renal-endothelial-cells
#11
JOURNAL ARTICLE
Rosa G M Lammerts, Lisanne M Lagendijk, Gesa Tiller, Wendy A Dam, Harriet L Lancaster, Mohamed R Daha, Marc A Seelen, Bouke G Hepkema, Robert A Pol, Henri G D Leuvenink, Grietje Molema, Jacob van den Born, Stefan P Berger
Renal endothelial cells (ECs) play crucial roles in vasorelaxation, ultrafiltration, and selective transport of electrolytes and water, but also in leakage of the glomerular filtration barrier and inflammatory processes like complement activation and leukocyte recruitment. In addition, they are target cells for both cellular and antibody-mediated rejection in the transplanted kidney. To study the molecular and cellular processes underlying EC behavior in renal disease, well-characterized primary renal ECs are indispensible...
May 1, 2021: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/33333969/angiopoietin-2-promotes-inflammatory-activation-in-monocytes-of-systemic-sclerosis-patients
#12
JOURNAL ARTICLE
Tiago Carvalheiro, Ana P Lopes, Maarten van der Kroef, Beatriz Malvar-Fernandez, Carlos Rafael-Vidal, Anneline C Hinrichs, Nila H Servaas, Femke Bonte-Mineur, Marc R Kok, Lorenzo Beretta, Maili Zimmermann, Wioleta Marut, Jose M Pego-Reigosa, Timothy R D J Radstake, Samuel Garcia
Angiopoietin-2 (Ang-2), a ligand of the tyrosine kinase receptor Tie2, is essential for vascular development and blood vessel stability and is also involved in monocyte activation. Here, we examined the role of Ang-2 on monocyte activation in patients with systemic sclerosis (SSc). Ang-2 levels were measured in serum and skin of healthy controls (HCs) and SSc patients by ELISA and array profiling, respectively. mRNA expression of ANG2 was analyzed in monocytes, dermal fibroblasts, and human pulmonary arterial endothelial cells (HPAECs) by quantitative PCR...
December 15, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/33152113/tie2-expressing-monocytes-as-a-novel-angiogenesis-related-cellular-biomarker-for-non-small-cell-lung-cancer
#13
JOURNAL ARTICLE
Rui Xue, Yuqiao Sheng, Xixi Duan, Yang Yang, Shengli Ma, Jingjing Xu, Na Wei, Xiaoping Shang, Feng Li, Jiajia Wan, Zhihai Qin
To investigate the clinical value of Tie2-expressing monocytes (TEMs) in the early diagnosis of lung cancer and assess its correlation with angiogenesis, a total of 184 patients with non-small cell lung cancer (NSCLC), 101 patients with benign pulmonary disease (BPD), and 77 healthy controls were enrolled in our study. The distribution of TEMs in lung tissue was determined by immunofluorescence staining. Lung microvascular density was assessed by immunohistochemical staining. Receiver-operating characteristic (ROC) curve analysis was performed to assess the diagnostic value of TEM frequency...
March 15, 2021: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/32982281/circulating-tie2-expressing-monocytes-a-potential-biomarker-for-cervical-cancer
#14
JOURNAL ARTICLE
Qing Han, Quan Zhang, Feiquan Ying, Zehua Wang, Yifan Zhang, Lanqing Gong, E Cai, Jiaxian Qian, Jing Cai
BACKGROUND: Tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 2 (Tie2)-expressing monocytes (TEMs) are a highly proangiogenic subset of myeloid cells, which are characterized by expressing the angiopoietin receptor Tie2 with pro-tumor activity. PURPOSE: The present study aimed to determine the clinical value of circulating TEMs (cTEMs) for cervical cancer. PATIENTS AND METHODS: Peripheral blood mononuclear cells (PBMCs) were obtained from 7 healthy volunteers, 17 uterine fibroid patients, 24 cervical intraepithelial neoplasia (CIN) II patients, 31 CIN III patients and 99 patients with cervical cancer...
2020: OncoTargets and Therapy
https://read.qxmd.com/read/32938724/hypoxia-inducible-factor-%C3%AE-subunits-regulate-tie2-expressing-macrophages-that-influence-tumor-oxygen-and-perfusion-in-murine-breast-cancer
#15
JOURNAL ARTICLE
Kayla J Steinberger, Mary A Forget, Andrey A Bobko, Nicole E Mihalik, Marieta Gencheva, Julie M Roda, Sara L Cole, Xiaokui Mo, E Hannah Hoblitzell, Randall Evans, Amy C Gross, Leni Moldovan, Clay B Marsh, Valery V Khramstov, Timothy D Eubank
Tie2-expressing monocytes/macrophages (TEMs) are a distinct subset of proangiogenic monocytes selectively recruited to tumors in breast cancer. Because of the hypoxic nature of solid tumors, we investigated if oxygen, via hypoxia-inducible transcription factors HIF-1α and HIF-2α, regulates TEM function in the hypoxic tumor microenvironment. We orthotopically implanted PyMT breast tumor cells into the mammary fat pads of syngeneic LysMcre, HIF-1α fl/fl /LysMcre, or HIF-2α fl/fl /LysMcre mice and evaluated the tumor TEM population...
October 15, 2020: Journal of Immunology
https://read.qxmd.com/read/32555748/retraction-macrophage-colony-stimulating-factor-augments-tie2-expressing-monocyte-differentiation-angiogenic-function-and-recruitment-in-a-mouse-model-of-breast-cancer
#16
JOURNAL ARTICLE
https://read.qxmd.com/read/32165607/recipient-hepatic-tumor-associated-immunologic-infiltrates-predict-outcomes-after-liver-transplantation-for-hepatocellular-carcinoma
#17
JOURNAL ARTICLE
Georgi Atanasov, Karoline Dino, Katrin Schierle, Corinna Dietel, Gabriela Aust, Johann Pratschke, Daniel Seehofer, Moritz Schmelzle, Hans-Michael Hau
BACKGROUND Transplantation of the liver entails a state of altered recipient immunologic competence. There are only scarce data concerning the impact of host immunologic factors on the outcome of liver transplant recipients in the context of hepatocellular carcinoma (HCC). MATERIAL AND METHODS Our study focused on evaluating the presence of tumor necrosis and frequency levels of angiopoietins and monocytes/macrophages subtypes in the host liver prior to liver transplantation (LTX) and their association with recurrence, graft rejection, survival, and clinical prognosis after LTX...
March 13, 2020: Annals of Transplantation: Quarterly of the Polish Transplantation Society
https://read.qxmd.com/read/31830991/angiogenic-inflammation-and-formation-of-necrosis-in-the-tumor-microenvironment-influence-patient-survival-after-radical-surgery-for-de-novo-hepatocellular-carcinoma-in-non-cirrhosis
#18
JOURNAL ARTICLE
Georgi Atanasov, Karoline Dino, Katrin Schierle, Corinna Dietel, Gabriela Aust, Johann Pratschke, Daniel Seehofer, Moritz Schmelzle, Hans-Michael Hau
BACKGROUND: Tumor escape mechanisms mediated in the tumor microenvironment can significantly reduce the capacity of the anti-tumor function of the immune system. TIE2-expressing monocytes (TEMs), related angiopoietins, and tumor necrosis are considered to have a key role in this process. We aimed to investigate the abundance and clinical significance of these biomarkers in hepatocellular carcinoma (HCC). METHODS: In this retrospective study, 58 HCC patients received surgery with a curative intent...
December 12, 2019: World Journal of Surgical Oncology
https://read.qxmd.com/read/31377797/promotion-of-macrophage-activation-by-tie2-in-the-context-of-the-inflamed-synovia-of-rheumatoid-arthritis-and-psoriatic-arthritis-patients
#19
JOURNAL ARTICLE
Pawel A Kabala, Beatriz Malvar-Fernández, Ana P Lopes, Tiago Carvalheiro, Sarita A Y Hartgring, Man Wai Tang, Carmen Conde, Dominique L Baeten, Matthew Sleeman, Paul P Tak, Jane Connor, Timothy R Radstake, Kris A Reedquist, Samuel García
OBJECTIVE: To examine the role of Tie2 signalling in macrophage activation within the context of the inflammatory synovial microenvironment present in patients with RA and PsA. METHODS: Clinical responses and macrophage function were examined in wild-type and Tie2-overexpressing (Tie2-TG) mice in the K/BxN serum transfer model of arthritis. Macrophages derived from peripheral blood monocytes from healthy donors, RA and PsA patients, and RA and PsA synovial tissue explants were stimulated with TNF (10 ng/ml), angiopoietin (Ang)-1 or Ang-2 (200 ng/ml), or incubated with an anti-Ang2 neutralizing antibody...
February 1, 2020: Rheumatology
https://read.qxmd.com/read/31102457/pde5-inhibition-stimulates-tie2-expressing-monocytes-and-angiopoietin-1-restoring-angiogenic-homeostasis-in-diabetes
#20
JOURNAL ARTICLE
Mary Anna Venneri, Federica Barbagallo, Daniela Fiore, Rita De Gaetano, Elisa Giannetta, Emilia Sbardella, Carlotta Pozza, Federica Campolo, Fabio Naro, Andrea Lenzi, Andrea M Isidori
CONTEXT: Vascular dysfunction is a common feature in end-organ complications of type 2 diabetes mellitus (T2DM). The endothelium-specific receptor tyrosine kinase Tie2 and its ligand, angiopoietin-1 (Ang1), participate in the processes of vessel repair, renewal, and maturation. However, their dysregulation in T2DM has seldom been investigated. OBJECTIVES: To examine the relationship between angiogenic Tie2-expressing monocytes (TEMs) and Ang1, and their pharmacological modulation by the phosphodiesterase type 5 inhibitor (PDE5i) sildenafil, in T2DM and in db/db mouse model...
July 1, 2019: Journal of Clinical Endocrinology and Metabolism
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