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https://www.readbyqxmd.com/read/27908924/excess-weight-as-a-risk-factor-common-to-many-cancer-sites-words-of-caution-when-interpreting-meta-analytic-evidence
#1
Melina Arnold, Andrew G Renehan, Graham A Colditz
For over a decade, excess body weight, commonly categorized as overweight (body mass index, BMI: 25.0 to 29.9 kg/m2) and obesity (BMI: ≥ 30 kg/m2) has been an established incidence risk factor for several adult cancers (1). For 2012, the burden of disease attributed to elevated BMI was estimated as nearly half-million new cancers worldwide, making this the third highest ranked cancer risk factor globally after smoking and infections (ranked second in most western populations) and an important public health problem (2, 3)...
December 1, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27867048/feasibiility-and-learning-curve-of-robotic-laparo-endoscopic-single-site-surgery-in-gynecology
#2
Alexandre Buckley de Meritens, Julia Kim, Helen Dinkelspiel, Eloise Chapman-Davis, Thomas Caputo, Kevin Holcomb
Single-site laparoscopy has proven to be a desirable option for patients undergoing gynecologic surgery with some studies indicating improved cosmesis and less perioperative pain compared to standard approaches. This study describes the safety and feasibility of a novel robotic laparo-endoscopic single-site surgery (R-LESS) platform as it is incorporated into a surgeon's practice with extensive multiport robotic surgical experience but limited laparo-endoscopic single-site experience. We reviewed 83 women undergoing R-LESS by a single surgeon from September 2013 through August 2015...
November 17, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27798047/common-diseases-as-determinants-of-menopausal-age
#3
Jingmei Li, Mikael Eriksson, Kamila Czene, Per Hall, Kenny A Rodriguez-Wallberg
STUDY QUESTION: Can the diagnosis of common diseases before menopause influence age at natural menopause (ANM) onset? SUMMARY ANSWER: Polycystic ovary syndrome (PCOS) and depression were observed to delay menopause. WHAT IS KNOWN ALREADY: It has been observed that women who undergo early menopause experience a higher burden of health problems related to metabolic syndromes, heart disease and depression, but whether ANM can be influenced by common adult diseases has not been studied extensively...
October 18, 2016: Human Reproduction
https://www.readbyqxmd.com/read/27667654/long-and-irregular-menstrual-cycles-polycystic-ovary-syndrome-and-ovarian-cancer-risk-in-a-population-based-case-control-study
#4
H R Harris, L J Titus, D W Cramer, K L Terry
Long and irregular menstrual cycles, a hallmark of polycystic ovary syndrome (PCOS), have been associated with higher androgen and lower sex hormone binding globulin levels and this altered hormonal environment may increase the risk of specific histologic subtypes of ovarian cancer. We investigated whether menstrual cycle characteristics and self-reported PCOS were associated with ovarian cancer risk among 2,041 women with epithelial ovarian cancer and 2,100 controls in the New England Case-Control Study (1992-2008)...
January 15, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27320647/-initial-experience-in-the-laparoscopic-treatment-of-benign-and-malignant-gynaecological-diseases-in-the-hospital-regional-de-alta-especialidad-in-oaxaca
#5
Sergio Vásquez-Ciriaco, David Isla-Ortiz, Antonio Palomeque-Lopez, Jaime Aron García-Espinoza, Arturo Jarquín-Arremilla, Néstor Alonso Lechuga-García
BACKGROUND: The history of laparoscopic surgery in gynaecological diseases progressed with the advances of Semm, as well as with the development of tools, equipment, and energy that led to its development in all surgical areas, including oncology. OBJECTIVE: To present the initial experience in the laparoscopic treatment of benign and malignant gynaecological disease in the Hospital Regional de Alta Especialidad in Oaxaca. MATERIAL AND METHODS: An analysis was performed on a total of 44 cases, distributed into: type III radical hysterectomy for invasive cervical cancer, hysterectomy type I cervical cancer in situ, extrafascial hysterectomy for benign disease, routine endometrium, ovary and routine salpingo-oophorectomy...
June 16, 2016: Cirugia y Cirujanos
https://www.readbyqxmd.com/read/27189894/probability-of-fallopian-tube-and-ovarian-detection-with-transvaginal-ultrasonography-in-normal-women
#6
Jason R Lefringhouse, Erin Neward, Frederick R Ueland, Lauren A Baldwin, Rachel W Miller, Christopher P DeSimone, Richard J Kryscio, John R van Nagell, Edward J Pavlik
OBJECTIVE: Some ovarian malignancies may originate in the fallopian tube. The feasibility of ultrasonographically visualizing the fallopian tube is presented. METHODS: In total, 549 normal women participated in the fallopian tube visualization trial, while ovarian visualization was studied in 43,521. Chi-square analysis, t-tests and multivariate analysis determined significance and interactions. RESULTS: Ovaries were observed in 82.7% while fallopian tubes were detected in 77...
June 2016: Women's Health
https://www.readbyqxmd.com/read/26802879/up-regulation-of-genes-involved-in-the-insulin-signalling-pathway-igf1-pten-and-igfbp1-in-the-endometrium-may-link-polycystic-ovarian-syndrome-and-endometrial-cancer
#7
Mohamad Nasir Shafiee, Claire Seedhouse, Nigel Mongan, Caroline Chapman, Suha Deen, Jafaru Abu, William Atiomo
BACKGROUND: Endometrial cancer (EC) is the most common gynaecological cancer amongst women in the UK. Although previous studies have found that women with polycystic ovary syndrome (PCOS) have at least a three-fold increase in endometrial cancer (EC) risk compared to women without PCOS, the precise molecular mechanisms which link between PCOS and EC remain unclear. It has been suggested that insulin resistance may contribute to the increased risk of EC in PCOS. The specific expression of genes related to the insulin-signalling pathway including the IGF system in the endometrium of women with PCOS has however never been measured and compared to that in women with EC without PCOS and control women without EC or PCOS...
March 15, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/26539805/circulating-levels-of-adipocytokine-omentin-1-in-patients-with-renal-cell-cancer
#8
Xu-Dong Shen, Li Zhang, Hong Che, Yang-Yang Zhang, Cheng Yang, Jun Zhou, Chao-Zhao Liang
Renal cell carcinoma (RCC) is the fifth most common cancer worldwide, and becomes one of the leading causes of genitourinary cancer-related death in both males and females. Genetic alternations, alcohol consumption, occupationally harmful exposure and even obesity are well-established risk factors of RCC. Omentin-1 is a plasma adipokine synthesized in visceral adipose tissue, and its circulating serum concentration alters not only in conditions associated with insulin resistance such as Polycystic Ovary Syndrome (PCOS), but also in colorectal cancer and prostate cancer...
January 2016: Cytokine
https://www.readbyqxmd.com/read/26509855/american-association-of-clinical-endocrinologists-american-college-of-endocrinology-and-androgen-excess-and-pcos-society-disease-state-clinical-review-guide-to-the-best-practices-in-the-evaluation-and-treatment-of-polycystic-ovary-syndrome-part-1
#9
Neil F Goodman, Rhoda H Cobin, Walter Futterweit, Jennifer S Glueck, Richard S Legro, Enrico Carmina
Polycystic Ovary Syndrome (PCOS) is recognized as the most common endocrine disorder of reproductive-aged women around the world. This document, produced by the collaboration of the American Association of Clinical Endocrinologists (AACE) and the Androgen Excess and PCOS Society (AES) aims to highlight the most important clinical issues confronting physicians and their patients with PCOS. It is a summary of current best practices in 2015. PCOS has been defined using various criteria, including menstrual irregularity, hyperandrogenism, and polycystic ovary morphology (PCOM)...
November 2015: Endocrine Practice
https://www.readbyqxmd.com/read/26225266/low-starch-low-dairy-diet-results-in-successful-treatment-of-obesity-and-co-morbidities-linked-to-polycystic-ovary-syndrome-pcos
#10
Jennifer L Phy, Ali M Pohlmeier, Jamie A Cooper, Phillip Watkins, Julian Spallholz, Kitty S Harris, Abbey B Berenson, Mallory Boylan
BACKGROUND: Polycystic Ovary Syndrome (PCOS) affects approximately 15% of reproductive-age women and increases risk of insulin resistance, type 2 diabetes mellitus, cardiovascular disease, cancer and infertility. Hyperinsulinemia is believed to contribute to or worsen all of these conditions, and increases androgens in women with PCOS. Carbohydrates are the main stimulators of insulin release, but research shows that dairy products and starches elicit greater postprandial insulin secretion than non-starchy vegetables and fruits...
April 2015: Journal of Obesity & Weight Loss Therapy
https://www.readbyqxmd.com/read/26215293/impact-of-smoking-and-excess-body-weight-on-overall-and-site-specific-cancer-mortality-risk
#11
Julia Meyer, Sabine Rohrmann, Matthias Bopp, David Faeh
BACKGROUND: Smoking and excess body weight are major preventable risk factors for premature death. This study aimed at analyzing their single and combined association with site-specific cancer mortality. METHODS: Our study population comprised 35,784 men and women of ages 14 to 99 years, who participated in population-based health surveys conducted 1977-1993 in Switzerland and were followed up for mortality until 2008. Multivariable Cox proportional hazards models were calculated for different cancer sites, and population attributable fractions were derived...
October 2015: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/25675036/correlation-between-location-of-transposed-ovary-and-function-in-cervical-cancer-patients-who-underwent-radical-hysterectomy
#12
Aera Yoon, Yoo-Young Lee, Won Park, Seung Jae Huh, Chel Hun Choi, Tae-Joong Kim, Jeong-Won Lee, Byoung-Gie Kim, Duk-Soo Bae
OBJECTIVE: The study investigated the association between the location of transposed ovaries and posttreatment ovarian function in patients with early cervical cancer (IB1-IIA) who underwent radical hysterectomy and ovarian transposition with or without adjuvant therapies. METHODS: Retrospective medical records were reviewed to enroll the patients with early cervical cancer who underwent ovarian transposition during radical hysterectomy at Samsung Medical Center between July 1995 and July 2012...
May 2015: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/25575587/an-international-ecological-study-of-adult-height-in-relation-to-cancer-incidence-for-24-anatomical-sites
#13
Yannan Jiang, Roger J Marshall, Sarah C Walpole, David Prieto-Merino, Dong-Xu Liu, Jo K Perry
BACKGROUND: Anthropometric indices associated with childhood growth and height attained in adulthood, have been associated with an increased incidence of certain malignancies. To evaluate the cancer-height relationship, we carried out a study using international data, comparing various cancer rates with average adult height of women and men in different countries. METHODS: An ecological analysis of the relationship between country-specific cancer incidence rates and average adult height was conducted for twenty-four anatomical cancer sites...
March 2015: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/25256873/evaluation-of-the-pro-inflammatory-cytokine-tumor-necrosis-factor-%C3%AE-in-adolescents-with-polycystic-ovary-syndrome
#14
Melissa Pawelczak, Jamie Rosenthal, Sarah Milla, Ying-Hua Liu, Bina Shah
BACKGROUND: Patients with polycystic ovary syndrome (PCOS) often suffer from comorbidities associated with chronic inflammation characterized by elevations in pro-inflammatory cytokines. There is limited data on markers of chronic inflammation, in particular Tumor Necrosis Factor-alpha (TNF-α), in adolescents with PCOS. OBJECTIVES: To compare serum levels of TNF-α in overweight or obese adolescents with PCOS and obese controls. In the PCOS group, to correlate serum TNF-α levels with body mass index (BMI) z-score, severity of hyperandrogenism, degree of insulin resistance, and ovarian ultrasonographic characteristics...
December 2014: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/25221714/factors-influencing-endometrial-thickness-in-postmenopausal-women
#15
S Hebbar, V Chaya, L Rai, A Ramachandran
BACKGROUND: Cut-off values for endometrial thickness (ET) in asymptomatic postmenopausal woman have been standardized. However, there are no comprehensive studies to document how various factors can influence the ET after the age of menopause. AIM: To study the various factors influencing the ET in postmenopausal women. SUBJECTS AND METHODS: This was a prospective observational study. A total of 110 postmenopausal women underwent detailed history taking, clinical examination, and transvaginal scan for uterine volume and ovarian volume...
July 2014: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/24997743/body-mass-index-and-cancer-incidence-the-finrisk-study
#16
Xin Song, Eero Pukkala, Tadeusz Dyba, Jaakko Tuomilehto, Vladislav Moltchanov, Satu Männistö, Pekka Jousilahti, Qing Qiao
The relation between body mass index (BMI) and risk of cancer incidence is controversial. Cancer incidence during 1972-2008 in relation to BMI was investigated in a prospective cohort of 54,725 Finns aged 24-74 years and free of cancer at enrollment. Over a mean follow-up of 20.6 years, 8,429 (15.4%) incident cancers were recorded, 4,208 (49.9%) from men. Both parametric and nonparametric approaches were used to evaluate the shape of the relationship between BMI and incidence of cancer. BMI had a linear positive association with incidence of cancers of the colon, liver, kidney, bladder and all sites combined in men, and of cancers of the stomach, colon, gallbladder and ovary in women, an inverse association with incidence of cancers of the lung in men and the lung and breast in women, a J-shaped association with incidence of all cancers combined in women...
July 2014: European Journal of Epidemiology
https://www.readbyqxmd.com/read/24842895/lifestyle-intervention-up-regulates-gene-and-protein-levels-of-molecules-involved-in-insulin-signaling-in-the-endometrium-of-overweight-obese-women-with-polycystic-ovary-syndrome
#17
D Ujvari, M Hulchiy, A Calaby, Å Nybacka, B Byström, A L Hirschberg
STUDY QUESTION: Does lifestyle intervention aiming at weight loss influence endometrial insulin signaling in overweight/obese women with polycystic ovary syndrome (PCOS)? SUMMARY ANSWER: Lifestyle intervention up-regulates, both at the mRNA and protein levels, components of insulin signaling in the endometrium of overweight/obese PCOS women, in relation to an improved menstrual pattern. WHAT IS KNOWN ALREADY: PCOS is a multifactorial endocrine disorder diagnosed by two of the following three criteria: chronic anovulation, hyperandrogenism and polycystic ovaries...
July 2014: Human Reproduction
https://www.readbyqxmd.com/read/24765893/the-percentages-of-endometrial-hyperplasia-and-endometrial-cancer-among-polycystic-ovary-syndrome-pcos-patients-presenting-with-abnormal-menstrual-pattern
#18
Noppakorn Prakansamut, Porntip Sirayapiwat, Surang Triratanachat
OBJECTIVE: Assess the occurrence of endometrial hyperplasia and endometrial cancer among PCOS patients having abnormal menstrual pattern. Endometrial thickness and other clinical characteristics associated with endometrial hyperplasia and endometrial cancer were also evaluated MATERIAL AND METHOD: Women with PCOS and abnormal menstrual pattern were enrolled into this cross-sectional study. Endometrial thicknesses were evaluated using transvaginal sonography. Endometrial aspiration was performed with endometrial aspirator and sent for pathology...
February 2014: Journal of the Medical Association of Thailand, Chotmaihet Thangphaet
https://www.readbyqxmd.com/read/24748626/prevalence-of-malnutrition-and-current-use-of-nutrition-support-in-patients-with-cancer
#19
Xavier Hébuterne, Etienne Lemarié, Mauricette Michallet, Claude Beauvillain de Montreuil, Stéphane Michel Schneider, François Goldwasser
BACKGROUND AND AIMS: The aim of this study was to evaluate on 1 day the prevalence of malnutrition in different types of cancer and the use of nutrition support in patients with cancer. METHODS: A 1-day prevalence survey was carried out in 154 French hospital wards. Malnutrition was defined as a body mass index (BMI) <18.5 in patients <75 years old or <21 in patients ≥75 years old and/or body weight loss >10% since disease onset. Oral food intake was measured using a visual analog scale...
February 2014: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/24741198/variation-of-adverse-drug-reaction-profile-of-platinum-based-chemotherapy-with-body-mass-index-in-patients-with-solid-tumors-an-observational-study
#20
Dattatreyo Chatterjee, Somnath Roy, Avijit Hazra, Partha Dasgupta, Subir Ganguly, Anup Kumar Das
OBJECTIVES: Toxicity of cancer chemotherapy may be affected by nutritional status of patients which is reflected in the body mass index (BMI). We sought to assess whether the adverse drug reaction (ADR) profile of platinum-based chemotherapy varies with BMI status. MATERIALS AND METHODS: Adult patients of either sex, suffering from a solid tumor (lung, head and neck, ovary, gall bladder, stomach, colon) and started on platinum-based chemotherapy as initial treatment were included...
March 2014: Indian Journal of Pharmacology
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