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https://www.readbyqxmd.com/read/20105179/effects-of-peroxisome-proliferator-activated-receptor-gamma-agonists-on-na-transport-and-activity-of-the-kinase-sgk1-in-epithelial-cells-from-lung-and-kidney
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Stuart M Wilson, Morag K Mansley, Jennet Getty, Elaine M Husband, Sarah K Inglis, Michael K Hansen
BACKGROUND AND PURPOSE: Peroxisome proliferator-activated receptor gamma (PPARgamma) agonists, such as rosiglitazone and pioglitazone, sensitize cells to insulin, and are therefore used to treat type 2 diabetes. However, in some patients, these drugs induce oedema, and the present study tests the hypothesis that this side effect reflects serum and glucocorticoid-inducible kinase 1 (SGK1)-dependent enhancement of epithelia Na(+) absorption. EXPERIMENTAL APPROACH: Na(+) absorbing epithelial cells (H441 cells, mpkCCD cells) on permeable membranes were mounted in Ussing chambers, and the effects of rosiglitazone (2 microM) and pioglitazone (10 microM) on transepithelial Na(+) absorption were quantified electrometrically...
February 1, 2010: British Journal of Pharmacology
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