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https://www.readbyqxmd.com/read/28742187/pulmonell-hypertension-vanligt-vid-kronisk-lungsjukdom-europeiska-riktlinjer-kring-utredning-och-behandling
#1
David Kylhammar, Göran Rådegran
Pulmonary hypertension due to lung diseases In 2015 the European Society of Cardiology and European Respiratory Society published new guidelines on the diagnosis and treatment of pulmonary hypertension (PH). PH due to lung diseases and/or hypoxia was classified as a separate entity. PH is common in lung diseases, but seldom severe. Nevertheless, the presence of PH in a patient with lung disease is associated with worse outcome. If there is clinical suspicion of PH in a patient with lung disease, echocardiography is recommended, and if there are signs of severe PH and/or severe right ventricular dysfunction the patient should be referred to a PH expert centre...
July 21, 2017: Läkartidningen
https://www.readbyqxmd.com/read/28741603/role-of-the-lung-microbiome-in-the-pathogenesis-of-chronic-obstructive-pulmonary-disease
#2
REVIEW
Lei Wang, Ke Hao, Ting Yang, Chen Wang
OBJECTIVE: The development of culture-independent techniques for microbiological analysis shows that bronchial tree is not sterile in either healthy or chronic obstructive pulmonary disease (COPD) individuals. With the advance of sequencing technologies, lung microbiome has become a new frontier for pulmonary disease research, and such advance has led to better understanding of the lung microbiome in COPD. This review aimed to summarize the recent advances in lung microbiome, its relationships with COPD, and the possible mechanisms that microbiome contributed to COPD pathogenesis...
July 24, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28740835/severe-pulmonary-hypertension-due-to-combined-pulmonary-fibrosis-and-emphysema-another-cause-of-death-among-smokers
#3
REVIEW
André Carramenha de Góes Hirano, Eduardo Pelegrineti Targueta, Fernando Peixoto Ferraz de Campos, João Augusto Dos Santos Martines, Dafne Andrade, Silvana Maria Lovisolo, Aloisio Felipe-Silva
In 2005, the combined pulmonary fibrosis and emphysema (CPFE) was first defined as a distinct entity, which comprised centrilobular or paraseptal emphysema in the upper pulmonary lobes, and fibrosis in the lower lobes accompanied by reduced diffused capacity of the lungs for carbon monoxide (DLCO). Recently, the fibrosis associated with the connective tissue disease was also included in the diagnosis of CPFE, although the exposure to tobacco, coal, welding, agrochemical compounds, and tire manufacturing are the most frequent causative agents...
April 2017: Autopsy & case reports
https://www.readbyqxmd.com/read/28740697/successful-treatment-of-acute-respiratory-failure-in-a-patient-with-pulmonary-mycobacterium-abscessus-infection-accompanied-by-organizing-pneumonia
#4
Goohyeon Hong, Doh Hyung Kim, Youn Seup Kim
Organizing pneumonia (OP) is an inflammatory lung disease characterized pathologically by the presence of buds of granulation tissue in the distal air spaces. There are numerous causes of OP including acute respiratory infections such as viral and bacterial infections. However, Mycobacterium abscessus (M. abscessus) has rarely been reported as a causative pathogen of OP. Here, we report a 67-year-old woman with rapidly progressive pulmonary M. abscessus infection who developed OP and acute respiratory failure (ARF)...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740685/minimally-invasive-aortic-valve-replacement-in-high-risk-patient-groups
#5
REVIEW
Daniel Fudulu, Harriet Lewis, Umberto Benedetto, Massimo Caputo, Gianni Angelini, Hunaid A Vohra
Minimally invasive aortic valve replacement (AVR) aims to preserve the sternal integrity and improve postoperative outcomes. In low risk patients, this technique can be achieved with comparable mortality to the conventional approach and there is evidence of possible reduction in intensive care and hospital length of stay, transfusion requirement, renal dysfunction, improved respiratory function and increased patient satisfaction. In this review, we aim to asses if these benefits can be transferred to the high risk patient groups...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740677/assessment-of-thoracic-vasculature-in-patients-with-central-bronchogenic-carcinoma-by-unenhanced-magnetic-resonance-angiography-comparison-between-2d-free-breathing-truefisp-2d-breath-hold-truefisp-and-3d-respiratory-triggered-space
#6
Lili Wang, Peng Lv, Shuohui Yang, Mengsu Zeng, Jiang Lin
BACKGROUND: Preoperative assessment of the integrity of major thoracic vessels in central bronchogenic carcinoma is vital for tumor staging and treatment planning. Contrast-enhanced CT is currently the first choice of modality for this purpose in clinical practice with limitations including exposure to ionizing radiation and the use of iodinated contrast material. MRI has been increasingly employed for the staging of lung cancer. More recently, unenhanced magnetic resonance angiography (MRA) which is totally non-invasive and contrast-free has been reported able to show thoracic vessels...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740672/effectiveness-of-perioperative-pulmonary-rehabilitation-in-thoracic-surgery
#7
Attila Vagvolgyi, Zsolt Rozgonyi, Maria Kerti, Paul Vadasz, Janos Varga
BACKGROUND: Functional condition is crucial for operability of patients with lung cancer and/or chronic respiratory diseases. The aim of the study was to measure changes of functional and quality of life parameters in terms of the effectiveness of perioperative pulmonary rehabilitation (PR). METHODS: A total of 208 COPD patients (age: 63±9 years, man/woman: 114/94, FEV1: 62±14%pred) participated in a perioperative PR program. The indication was primary lung cancer in 72% of the patients...
June 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28740376/fluticasone-propionate-formoterol-for-copd-management-a-randomized-controlled-trial
#8
A Papi, D Dokic, W Tzimas, I Mészáros, A Olech-Cudzik, Z Koroknai, K McAulay, S Mersmann, P S Dalvi, T Overend
PURPOSE: To evaluate fluticasone propionate/formoterol (FP/FORM) in COPD. PATIENTS AND METHODS: COPD patients with forced expiratory volume in 1 s (FEV1) ≤50% predicted and ≥1 moderate/severe COPD exacerbation in the last 12 months were randomized to FP/FORM 500/20 or 250/10 µg bid, or formoterol (FORM) 12 µg bid for 52 weeks. The primary outcome was the annualized rate of moderate/severe COPD exacerbations. RESULTS: In total, 1,765 patients were randomized...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28738733/cases-of-mortality-in-little-penguins-eudyptula-minor-in-new-zealand-associated-with-avian-malaria
#9
D C Sijbranda, S Hunter, L Howe, B Lenting, L Argilla, B D Gartrell
CASE HISTORY: A little penguin (Eudyptula minor) of wild origin, in captivity at Wellington Zoo, became inappetent and lethargic in March 2013. Despite supportive care in the zoo's wildlife hospital, the bird died within 24 hours. CLINICAL FINDINGS: Weight loss, dehydration, pale mucous membranes, weakness, increased respiratory effort and biliverdinuria were apparent on physical examination. Microscopic evaluation of blood smears revealed intra-erythrocytic stages of Plasmodium spp...
July 24, 2017: New Zealand Veterinary Journal
https://www.readbyqxmd.com/read/28738481/-progress-in-research-of-relationship-between-ambient-air-pm-2-5-and-lung-diseases
#10
Y Xia, L Fan, Y Guan, S Y Liu, Y Xiao
Fine Particulate Matter (PM(2.5)-particles with an aerodynamic diameter ≤2.5 μm) can penetrate deeply into the lung, deposit in the alveoli, and consequently impair lung function. Both short term and long term exposures to PM(2.5) are associated with the incidence of respiratory diseases (e.g. asthma, chronic obstructive pulmonary disease, lung cancer). This paper summarizes the effects of ambient air PM(2.5) exposure on human respiratory system revealed by epidemiological studies.
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/28738386/exercise-capacity-impairment-can-predict-postoperative-pulmonary-complications-after-liver-transplantation
#11
Clarissa Bentes de Araújo Magalhães, Ingrid Correia Nogueira, Liegina Silveira Marinho, Elizabeth F Daher, José Huygens P Garcia, Cyntia F G Viana, Pedro Felipe Carvalhedo de Bruin, Eanes Delgado Barros Pereira
BACKGROUND: Postoperative respiratory complications (PRCs) are common after liver transplantation (LT) and contribute significantly to the related morbidity and mortality. OBJECTIVE: The aim of this paper was to determine the incidence of PRCs after LT and the value of simple exercise capacity measures as independent predictors of PRCs. METHODS: We conducted a prospective cohort study of consecutive adults submitted to LT at a University Hospital in Fortaleza Brazil from March 2013 to March 2015...
July 22, 2017: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/28738246/crocin-modulates-il-4-il-13-signaling-and-ameliorates-experimentally-induced-allergic-airway-asthma-in-a-murine-model
#12
Haidy Yosri, Wagdi F Elkashef, Eman Said, Nariman M Gameil
Allergic asthma is a chronic respiratory disease with a prevalent T helper (Th2)-mediated immune reaction. Crocin, the major bioactive constituent of saffron, has been reported in multiple studies to have numerous pharmacological activities, including prominent anti-oxidant activities. In the current study, the anti-asthmatic potential of crocin was evaluated. Adult male Swiss Albino mice were administered 10mg of ovalbumin (OVA) mixed with 1mg of aluminum hydroxide intraperitoneally on days 0 and 7 and were administered crocin (25mg/kg) orally daily for 16days...
July 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28738158/efficient-interfacially-driven-vehiculization-of-corticosteroids-by-pulmonary-surfactant
#13
Alberto Hidalgo, Fabrizio Salomone, Nieves Fresno, Guillermo Orellana, Antonio Cruz, Jesus Perez-Gil
Pulmonary surfactant is a crucial system to stabilize the respiratory air-liquid interface. Furthermore, pulmonary surfactant has been proposed as an effective method for targeting drugs to the lungs. However, few studies have examined in detail the mechanisms of incorporation of drugs into surfactant, the impact of the presence of drugs on pulmonary surfactant performance at the interface under physiologically-meaningful conditions, or the ability of pulmonary surfactant to use the air-liquid interface to vehiculise drugs to long distances...
July 24, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28737279/exercise-capacity-is-not-decreased-in-children-who-have-undergone-lung-resection-early-in-life-for-congenital-thoracic-malformations-compared-to-healthy-age-matched-children
#14
Ashlee Dunn, Kasey Pearce, Robin Callister, Adam Collison, Matthew Morten, Payal Mandaliya, Lauren Platt, Ben Dascombe, Rajendra Kumar, Hiran Selvadurai, Paul D Robinson, Joerg Mattes
PURPOSE: The purpose of this study was to compare (i) the exercise capacity and (ii) lung function prior to and immediately post cardiopulmonary exercise tests (CPET) of children who underwent early life lung resection for Congenital Pulmonary Airway Malformations (CPAM) to healthy control children. METHOD: Eight children with CPAM (four males, age 9.6 ± 1.8 years) and eight control children without respiratory disease (three males, age 9.4 ± 1.4 years) performed a CPET on a cycle ergometer, during which maximal oxygen consumption (V̇O2max ) and heart rate were measured...
July 24, 2017: Pediatric Pulmonology
https://www.readbyqxmd.com/read/28736210/effects-of-positive-expiratory-pressure-on-chest-wall-volumes-in-subjects-with-stroke-compared-to-healthy-controls-a-case-control-study
#15
Elis E A Cabral, Vanessa R Resqueti, Illia N D F Lima, Lucien P Gualdi, Andrea Aliverti, Guilherme A F Fregonezi
BACKGROUND: Alterations in respiratory system kinematics in stroke lead to restrictive pattern associated with decreased lung volumes. Chest physical therapy, such as positive expiratory pressure, may be useful in the treatment of these patients; however, the optimum intensity to promote volume and motion changes of the chest wall remains unclear. OBJECTIVE: To assess the effect of different intensities of positive expiratory pressure on chest wall kinematics in subjects with stroke compared to healthy controls...
July 8, 2017: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/28735670/concomitant-malignant-pulmonary-peripheral-nerve-sheath-tumour-and-benign-cutaneous-peripheral-nerve-sheath-tumour-in-a-dog
#16
E O Silva, P F I Goiozo, L G Pereira, S A Headley, A F R L Bracarense
Peripheral nerve sheath tumours (PNSTs) are neoplastic growths derived from Schwann cells, perineural cells or both. Malignant PNSTs (MPNSTs) are uncommon in domestic animals. This report describes the concomitant occurrence of PNSTs in a 10-year-old female cocker spaniel with a clinical history of respiratory impairment. Grossly, there was a large infiltrative mass in the caudal lobe of the right lung; smaller nodules were observed in the other lobes of the right lung. Furthermore, a small encapsulated cutaneous nodule was observed on the left hindlimb...
July 2017: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/28734808/-congenital-cytomegalovirus-infection-manifesting-as-neonatal-respiratory-distress-in-an-hiv-exposed-uninfected-newborn
#17
A Pham, H El Mjati, N Nathan, F Kieffer, D Mitanchez
BACKGROUND: Cytomegalovirus (CMV) is one of the most common intrauterine infections, affecting approximately 1% of all live births. There are few reports on congenital CMV infections manifesting as isolated pneumonitis. CASE REPORT: We report a case of congenital CMV with neonatal respiratory distress affecting an HIV-exposed uninfected infant. This infant required noninvasive ventilation beginning within the first 15min of life. The initial chest X-ray showed diffuse bilateral ground-glass opacifications...
July 19, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28733270/evaluating-a-web-based-coaching-program-using-electronic-health-records-for-patients-with-chronic-obstructive-pulmonary-disease-in-china-randomized-controlled-trial
#18
Lan Wang, Lin He, Yanxia Tao, Li Sun, Hong Zheng, Yashu Zheng, Yuehao Shen, Suyan Liu, Yue Zhao, Yaogang Wang
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is now the fourth leading cause of death in the world, and it continues to increase in developing countries. The World Health Organization expects COPD to be the third most common cause of death in the world by 2020. Effective and continuous postdischarge care can help patients to maintain good health. The use of electronic health records (EHRs) as an element of community health care is new technology in China. OBJECTIVE: The aim of this study was to develop and evaluate a Web-based coaching program using EHRs for physical function and health-related quality of life for patients with COPD in China...
July 21, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28732839/exacerbations-and-duration-of-smoking-abstinence-are-associated-with-the-annual-loss-of-fev1-in-individuals-with-pizz-alpha-1-antitrypsin-deficiency
#19
Sebastian Fähndrich, Nikolas Bernhard, Philipp M Lepper, Claus Vogelmeier, Martina Seibert, Stefan Wagenpfeil, Robert Bals
BACKGROUND: Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that is associated with a higher risk of chronic obstructive pulmonary disease (COPD) and emphysema. The annual declines in lung function (FEV1) and transfer factor of the lung for carbon monoxide (TLCO) predict all-cause mortality. MATERIAL AND METHODS: We investigated the longitudinal follow-up data over 11 years (mean follow-up period of 4.89 years) from the German AATD registry and analyzed the relationship between annual loss of FEV1 and TLCO and sex, age, body mass index (BMI), nicotine consumption, occupational dust exposure, St...
August 2017: Respiratory Medicine
https://www.readbyqxmd.com/read/28732825/heterogeneity-of-lung-disease-associated-with-nk2-homeobox-1-mutations
#20
Elodie Nattes, Stephanie Lejeune, Ania Carsin, Raphael Borie, Isabelle Gibertini, Juan Balinotti, Nadia Nathan, Sylvain Marchand-Adam, Caroline Thumerelle, Brigitte Fauroux, Emmanuelle Bosdure, Veronique Houdouin, Celine Delestrain, MaleK Louha, Remy Couderc, Alix De Becdelievre, Pascale Fanen, Benoit Funalot, Bruno Crestani, Antoine Deschildre, Jean-Christophe Dubus, Ralph Epaud
We retrospectively studied the clinical presentation, treatment modalities and outcome in 16 patients with heterozygous NKX2-1 mutation associated with chronic lung disease. Twelve different NKX2-1 mutations, including 4 novel mutations, were identified in the 16 patients. Nine patients presented with brain-lung-thyroid syndrome, 3 had neurological and lung symptoms and 4 had only pulmonary symptoms. Ten patients had neonatal respiratory distress, and 6 of them developed infiltrative lung disease (ILD). The other patients were diagnosed with ILD in childhood (n = 3) or in adulthood (n = 3)...
August 2017: Respiratory Medicine
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