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Vulnerable carotid plaque

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https://www.readbyqxmd.com/read/28644968/serum-lipoprotein-associated-phospholipase-a2-predicts-the-formation-of-carotid-artery-plaque-and-its-vulnerability-in-anterior-circulation-cerebral-infarction
#1
Yuping Yang, Tao Xue, Juehua Zhu, Jiayi Xu, Xiaowei Hu, Penghao Wang, Tao Kong, Yan Yan, Lihui Yang, Shouru Xue
OBJECTIVE: Circulation inflammation markers such as high-sensitive C-reactive protein (hsCRP) and lipoprotein-associated phospholipase A2 (Lp-PLA2) are considered as predictors of cerebral and cardiac vascular diseases. However, the role of hsCRP and Lp-PLA2 in the anterior circulation cerebral infarction (ACI) is to be elaborated. PATIENTS AND METHODS: We included 100 patients with acute anterior circulation cerebral infarction (AaCI group) and 50 non-infarction subjects (control group)...
June 12, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/28642174/elevated-scd40l-mmp-9-and-mmp-2-is-associated-with-carotid-plaque-vulnerability-in-patients-with-ischemic-cerebrovascular-disease
#2
Yipeng Han, Xiang Mao, Lijun Wang, Jiachun Liu, Daming Wang, Hongwei Cheng, Guozhuan Miao
OBJECTIVES: The objectives of this study were to examine the correlation between the level of serum inflammatory markers and the stability of carotid plaques in patients with ischemic cerebrovascular disease and to assess the ability of each inflammatory marker to identify vulnerable carotid plaques. METHODS: for the Early Identification of Vulnerable Carotid Plaques Sixty-five patients with carotid plaques were divided into a stable plaque group (n = 21) and an unstable plaque group (n = 44) according to MRI characteristics...
June 19, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28639927/carotid-artery-plaque-vulnerability-assessment-using-noninvasive-ultrasound-elastography-validation-with-mri
#3
Marie-Hélène Roy Cardinal, Maarten H G Heusinkveld, Zhao Qin, Richard G P Lopata, Cyrille Naim, Gilles Soulez, Guy Cloutier
OBJECTIVE: Vulnerable and nonvulnerable carotid artery plaques have different tissue morphology and composition that may affect plaque biomechanics. The objective of this study is to evaluate plaque vulnerability with the use of ultrasound noninvasive vascular elastography (NIVE). MATERIALS AND METHODS: Thirty-one patients (mean [± SD] age, 69 ± 7 years) with stenosis of the internal carotid artery of 50% or greater were enrolled in this cross-sectional study...
July 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28623250/adamts-7-is-associated-with-a-high-risk-plaque-phenotype-in-human-atherosclerosis
#4
Eva Bengtsson, Karin Hultman, Pontus Dunér, Giuseppe Asciutto, Peter Almgren, Marju Orho-Melander, Olle Melander, Jan Nilsson, Anna Hultgårdh-Nilsson, Isabel Gonçalves
Several large-scale genome-wide association studies have identified single-nucleotide polymorphisms in the genomic region of A Disintegrin And Metalloproteinase with ThromboSpondin type 1 repeats (ADAMTS)-7 and associations to coronary artery disease. Experimental studies have provided evidence for a functional role of ADAMTS-7 in both injury-induced vascular neointima formation and development of atherosclerotic lesions. However, whether ADAMTS-7 is associated with a specific plaque phenotype in humans has not been investigated...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28594333/quantification-of-carotid-artery-plaque-stability-with-multiple-region-of-interest-based-ultrasound-strain-indices-and-relationship-with-cognition
#5
Nirvedh Meshram, Tomy Varghese, Carol Mitchell, Daren Jackson, Stephanie Wilbrand, Bruce Hermann, Robert Dempsey
Vulnerability and instability in carotid artery plaque has been assessed based on strain variations using noninvasive ultrasound imaging. We previously demonstrated that carotid plaques with higher strain indices in a region of interest (ROI) correlated to patients with lower cognition, probably due to cerebrovascular emboli arising from these unstable plaques. This work attempts to characterize the strain distribution throughout the entire plaque region instead of being restricted to a single localized ROI...
June 8, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28587323/clinical-relevance-of-gemstone-spectral-ct-in-the-diagnosis-of-carotid-atherosclerosis
#6
Jing-Jian Wang, Shu-Jie Fan, Long-Long Wang, Yan-Zhong Gao, Xiao-Juan Liu
A variety of imaging methods can be used in the diagnosis of atherosclerotic plaques. In the present study, we investigated the morphology and composition of atherosclerotic plaque associated with ischemic cerebral infarction by comparing gemstone spectral computed tomography (GSCT) and traditional multi-slice CT (MSCT). In total, 200 patients were enrolled and divided into the experimental group (n=100), which underwent GSCT, and the control group (n=100), which underwent MSCT. All the cases were followed up to observe disease outcomes in patients with different atherosclerotic plaque types, and adverse events in carotid artery stenosis or cerebral infarction were recorded...
June 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28585145/correlation-of-enhancement-degree-on-contrast-enhanced-ultrasound-with-histopathology-of-carotid-plaques-and-serum-high-sensitive-c-reactive-protein-levels-in-patients-undergoing-carotid-endarterectomy
#7
Li Xiong, Wei-Jun Sun, Hua-Ying Cai, Yuan Yang, Jiang Zhu, Bo-Wen Zhao
This study was undertaken to investigate the correlation of the enhancement degree on contrast-enhanced ultrasound (CEUS) with the histopathology of carotid plaques and the serum high sensitive C-reactive protein (hs-CRP) levels in patients undergoing carotid endarterectomy (CEA). Carotid CEUS was performed preoperatively in 115 patients who would undergo CEA, and the enhancement degree of the carotid plaques was evaluated by both the visual semiquantitative analysis and the quantitative time-intensity curve analysis...
June 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28559142/ag1296-enhances-plaque-stability-via-inhibiting-inflammatory-responses-and-decreasing-mmp-2-and-mmp-9-expression-in-apoe-mice
#8
Min Dong, Changping Zhou, Liang Ji, Bing Pan, Lemin Zheng
BACKGROUND: Atherosclerosis is a chronic process that progresses to unstable plaques. Plaque rupture leads to deleterious consequences such as acute coronary syndrome, thrombosis and stroke. AG1296 is a potent tyrosine kinase inhibitor which is able to block PDGF-PDGFR signaling pathway. This study aims to assess the effect of AG1296 on plaque stability and explore the potential mechanisms. METHODS: Atherosclerotic plaques were induced in carotid arteries in ApoE-/- mice by perivascular collar placement...
May 27, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28529262/investigations-of-carotid-stenosis-to-identify-vulnerable-atherosclerotic-plaque-and-determine-individual-stroke-risk
#9
Madieke I Liem, Fiona Kennedy, Leo H Bonati, Aad van der Lugt, Bram F Coolen, Aart J Nederveen, Hans R Jager, Martin M Brown, Paul J Nederkoorn
Selection of patients with atherosclerotic carotid stenosis for revascularization is mainly based on the degree of luminal narrowing of the carotid artery. However, identification of other features of plaque apart from the degree of stenosis could enable better selection for intervention if they are also associated with the occurrence of stroke. Before these risk factors can possibly play a role in treatment decisions, their prognostic value needs to be proven. The purpose of this narrative review is to summarize current knowledge regarding the risk factors for stroke in patients with carotid stenosis, how they can be determined, and to what extent they predict stroke, based on recent literature...
May 20, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28487806/synchronous-carotid-bifurcation-endarterectomy-and-retrograde-kissing-stenting-of-the-innominate-and-left-common-carotid-artery-in-a-patient-with-a-bovine-aortic-arch
#10
Alessandro Robaldo, Guido Carignano, Alberto Balderi, Claudio Novali
Management of the symptomatic multiple stenosis of supra-aortic vessels (MSSVs) in a "bovine" aortic arch (BAA) configuration is infrequently reported. The optimal treatment choice remains debatable. A successful hybrid treatment for a proximal critical stenosis of the innominate and left common carotid artery was performed in a high-risk patient with a tandem symptomatic lesion in the right carotid bifurcation and a concentric vulnerable plaque in the bovine trunk. This case supports the feasibility, safety, and efficacy of a combined carotid bifurcation endarterectomy and retrograde kissing stenting of common carotid arteries with cerebral protection after evaluation of radiological, anatomical, and clinical parameters...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28487317/head-to-head-comparison-of-inflammation-and-neovascularization-in-human-carotid-plaques-implications-for-the-imaging-of-vulnerable-plaques
#11
COMPARATIVE STUDY
Fabian Demeure, Caroline Bouzin, Véronique Roelants, Anne Bol, Robert Verhelst, Parla Astarci, Bernhard L Gerber, Anne-Catherine Pouleur, Agnès Pasquet, Christophe de Meester, Jean-Louis J Vanoverschelde, David Vancraeynest
BACKGROUND: Inflammation and intraplaque neovascularization are acknowledged to be 2 features of plaque vulnerability, although their temporal expression and their respective value in predicting clinical events are poorly understood. To determine their respective temporal associations, we conducted a comprehensive assessment of inflammation and intraplaque neovascularization in the carotid plaque of symptomatic and asymptomatic patients. METHODS AND RESULTS: Thirty patients with severe carotid stenosis underwent (18)F-fluorodeoxyglucose-positron emission tomography/computed tomographic imaging...
May 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28482222/noninvasive-detection-of-increased-carotid-artery-temperature-in-patients-with-coronary-artery-disease-predicts-major-cardiovascular-events-at-one-year-results-from-a-prospective-multicenter-study
#12
Konstantinos Toutouzas, Georgios Benetos, Iosif Koutagiar, Nikolaos Barampoutis, Fotini Mitropoulou, Periklis Davlouros, Petros P Sfikakis, Dimitrios Alexopoulos, Christodoulos Stefanadis, Elias Siores, Dimitris Tousoulis
BACKGROUND AND AIMS: Limited prospective data have been reported regarding the impact of carotid inflammation on cardiovascular events in patients with coronary artery disease (CAD). Microwave radiometry (MWR) is a noninvasive, simple method that has been used for evaluation of carotid artery temperature which, when increased, predicts 'inflamed' plaques with vulnerable characteristics. We prospectively tested the hypothesis that increased carotid artery temperature predicts future cerebro- and cardiovascular events in patients with CAD...
April 23, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28479433/relationship-between-calcification-and-vulnerability-of-the-carotid-plaques
#13
Rodolfo Pini, Gianluca Faggioli, Silvia Fittipaldi, Francesco Vasuri, Matteo Longhi, Enrico Gallitto, Gianandrea Pasquinelli, Mauro Gargiulo, Andrea Stella
BACKGROUND: Carotid plaques with a high degree of calcification are usually considered at low embolic risk. However, since a precise evaluation of the extent of calcification is not possible preoperatively through duplex ultrasound and postoperatively by conventional histological examination due to the decalcification process, the relationship between the amount of calcium involvement and plaque vulnerability has not been evaluated yet. This study aims to correlate the extent of carotid plaque calcification with clinical, radiological, and histological complications...
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28436693/expression-of-circulating-mir-17-92-cluster-and-hdac9-gene-in-atherosclerotic-patients-with-unstable-and-stable-carotid-plaques
#14
Silvia Ferronato, Aldo Mombello, Ilaria Posenato, Paola Candiani, Alberto Scuro, Carlo Setacci, Macarena Gomez-Lira
AIMS: The miR-17-92 cluster and the HDAC9 gene are involved in inflammatory, apoptotic, and angiogenic processes that are activated in the vulnerable carotid plaque. The aim of this research was to determine whether expression of one or more of the miRs of the miR-17-92 cluster and/or HDAC9 expression could represent biomarkers for patients with unstable atherosclerotic carotid plaques. MATERIALS AND METHODS: Plasma levels of miRs and HDAC9 expression in peripheral blood were analyzed by real-time PCR in patients with histologically classified stable or unstable plaques...
June 2017: Genetic Testing and Molecular Biomarkers
https://www.readbyqxmd.com/read/28412421/change-in-carotid-plaque-components-a-4-year-follow-up-study-with-serial-mr-imaging
#15
Laura Pletsch-Borba, Mariana Selwaness, Aad van der Lugt, Albert Hofman, Oscar H Franco, Meike W Vernooij
OBJECTIVES: The goal of this study was to determine how carotid plaque components (e.g., intraplaque hemorrhage [IPH], calcification, lipid core) change over time and which cardiovascular risk factors are associated with the development of each component. BACKGROUND: Carotid atherosclerotic plaque components are important markers of plaque vulnerability. How these components change and which factors lead to the development and changes in the components remain unclear...
April 10, 2017: JACC. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28411037/carotid-plaque-evaluation-using-gemstone-spectral-imaging-comparison-with-magnetic-resonance-angiography
#16
Yuki Shinohara, Makoto Sakamoto, Keita Kuya, Junichi Kishimoto, Eijiro Yamashita, Shinya Fujii, Masamichi Kurosaki, Toshihide Ogawa
BACKGROUND: The present study compared the applicability of computed tomography carotid plaque imaging using effective Z maps with gemstone spectral imaging (GSI) to that of magnetic resonance plaque imaging using 3-dimensional time-of-flight magnetic resonance angiography. METHODS: Stenosis was assessed in 18 carotid arteries of 14 patients, and the effective Z values of noncalcified carotid plaques were compared with the signal intensities of magnetic resonance angiography...
April 11, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/28402079/inverse-association-between-size-of-the-lipid-rich-necrotic-core-and-vascularization-in-human-carotid-plaques
#17
Ola Hjelmgren, Lars Johansson, Ulrica Prahl, Caroline Schmidt, Göran M L Bergström
PURPOSE: To study the relationship between the size of the lipid-rich necrotic core measured by MRI (magnetic resonance imaging) and the level of plaque vascularization measured by contrast-enhanced ultrasound, in human carotid plaques. Further, to compare the size of lipid-rich necrotic core from MRI to plaque echogenicity. METHODS: Thirty-one subjects with carotid plaques underwent standard B-mode ultrasound, contrast-enhanced ultrasound and MRI. The lipid-rich necrotic core was quantified using MRI...
April 12, 2017: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/28397443/an-evaluation-of-dual-source-computed-tomography-used-with-the-de-weert-classification-to-detect-vulnerable-plaque-using-ivus-virtual-histology-as-a-standard-of-reference
#18
Bartosz Dołęga-Kozierowski, Piotr Klimeczek, Michał Lis, Róża Krycińska, Anna Chrapusta, Urszula Zaleska-Dorobisz, Jerzy Garcarek, Wojciech Witkiewicz
BACKGROUND: One of the main risk factors for cerebral ischemic events is atherosclerotic disease of the internal carotid artery (ICA). Nowadays, increasing attention is being paid to the relationship between the morphological features of atherosclerotic plaque and the occurrence of stroke. Several studies have demonstrated that the presence of specific vulnerable plaque types, with a large lipid core and thin fibrous cap, can be used as an independent risk predictor of cerebral ischemic events...
January 2017: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://www.readbyqxmd.com/read/28390769/vascular-applications-of-contrast-enhanced-ultrasound-imaging
#19
REVIEW
Kunal S Mehta, Jake J Lee, Ashraf A Taha, Efthymios Avgerinos, Rabih A Chaer
OBJECTIVE: Contrast-enhanced ultrasound (CEUS) imaging is a powerful noninvasive modality offering numerous potential diagnostic and therapeutic applications in vascular medicine. CEUS imaging uses microbubble contrast agents composed of an encapsulating shell surrounding a gaseous core. These microbubbles act as nearly perfect intravascular reflectors of ultrasound energy and may be used to enhance the overall contrast and quality of ultrasound images. The purpose of this narrative review is to survey the current literature regarding CEUS imaging and discuss its diagnostic and therapeutic roles in current vascular and selected nonvascular applications...
July 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28388659/identification-of-neovascularization-by-contrast-enhanced-ultrasound-to-detect-unstable-carotid-stenosis
#20
Charlotte Schmidt, Thomas Fischer, Ralph-Ingo Rückert, Timm Oberwahrenbrock, Lutz Harms, Golo Kronenberg, Hagen Kunte
BACKGROUND: Plaque neovascularization accompanies local inflammation and critically contributes to plaque instability. Correct identification of intraplaque neovascularization by contrast-enhanced ultrasound (CEUS) may provide an additional risk marker in carotid stenosis. This pilot study investigates the correlation between histological evaluation of carotid plaque specimens and pre-surgery CEUS to identify neovascularization. METHODS: 17 patients with high-grade internal carotid artery (ICA) stenosis were studied...
2017: PloS One
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