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REVIEW
Deirdre K Tobias, Jordi Merino, Abrar Ahmad, Catherine Aiken, Jamie L Benham, Dhanasekaran Bodhini, Amy L Clark, Kevin Colclough, Rosa Corcoy, Sara J Cromer, Daisy Duan, Jamie L Felton, Ellen C Francis, Pieter Gillard, Véronique Gingras, Romy Gaillard, Eram Haider, Alice Hughes, Jennifer M Ikle, Laura M Jacobsen, Anna R Kahkoska, Jarno L T Kettunen, Raymond J Kreienkamp, Lee-Ling Lim, Jonna M E Männistö, Robert Massey, Niamh-Maire Mclennan, Rachel G Miller, Mario Luca Morieri, Jasper Most, Rochelle N Naylor, Bige Ozkan, Kashyap Amratlal Patel, Scott J Pilla, Katsiaryna Prystupa, Sridharan Raghavan, Mary R Rooney, Martin Schön, Zhila Semnani-Azad, Magdalena Sevilla-Gonzalez, Pernille Svalastoga, Wubet Worku Takele, Claudia Ha-Ting Tam, Anne Cathrine B Thuesen, Mustafa Tosur, Amelia S Wallace, Caroline C Wang, Jessie J Wong, Jennifer M Yamamoto, Katherine Young, Chloé Amouyal, Mette K Andersen, Maxine P Bonham, Mingling Chen, Feifei Cheng, Tinashe Chikowore, Sian C Chivers, Christoffer Clemmensen, Dana Dabelea, Adem Y Dawed, Aaron J Deutsch, Laura T Dickens, Linda A DiMeglio, Monika Dudenhöffer-Pfeifer, Carmella Evans-Molina, María Mercè Fernández-Balsells, Hugo Fitipaldi, Stephanie L Fitzpatrick, Stephen E Gitelman, Mark O Goodarzi, Jessica A Grieger, Marta Guasch-Ferré, Nahal Habibi, Torben Hansen, Chuiguo Huang, Arianna Harris-Kawano, Heba M Ismail, Benjamin Hoag, Randi K Johnson, Angus G Jones, Robert W Koivula, Aaron Leong, Gloria K W Leung, Ingrid M Libman, Kai Liu, S Alice Long, William L Lowe, Robert W Morton, Ayesha A Motala, Suna Onengut-Gumuscu, James S Pankow, Maleesa Pathirana, Sofia Pazmino, Dianna Perez, John R Petrie, Camille E Powe, Alejandra Quinteros, Rashmi Jain, Debashree Ray, Mathias Ried-Larsen, Zeb Saeed, Vanessa Santhakumar, Sarah Kanbour, Sudipa Sarkar, Gabriela S F Monaco, Denise M Scholtens, Elizabeth Selvin, Wayne Huey-Herng Sheu, Cate Speake, Maggie A Stanislawski, Nele Steenackers, Andrea K Steck, Norbert Stefan, Julie Støy, Rachael Taylor, Sok Cin Tye, Gebresilasea Gendisha Ukke, Marzhan Urazbayeva, Bart Van der Schueren, Camille Vatier, John M Wentworth, Wesley Hannah, Sara L White, Gechang Yu, Yingchai Zhang, Shao J Zhou, Jacques Beltrand, Michel Polak, Ingvild Aukrust, Elisa de Franco, Sarah E Flanagan, Kristin A Maloney, Andrew McGovern, Janne Molnes, Mariam Nakabuye, Pål Rasmus Njølstad, Hugo Pomares-Millan, Michele Provenzano, Cécile Saint-Martin, Cuilin Zhang, Yeyi Zhu, Sungyoung Auh, Russell de Souza, Andrea J Fawcett, Chandra Gruber, Eskedar Getie Mekonnen, Emily Mixter, Diana Sherifali, Robert H Eckel, John J Nolan, Louis H Philipson, Rebecca J Brown, Liana K Billings, Kristen Boyle, Tina Costacou, John M Dennis, Jose C Florez, Anna L Gloyn, Maria F Gomez, Peter A Gottlieb, Siri Atma W Greeley, Kurt Griffin, Andrew T Hattersley, Irl B Hirsch, Marie-France Hivert, Korey K Hood, Jami L Josefson, Soo Heon Kwak, Lori M Laffel, Siew S Lim, Ruth J F Loos, Ronald C W Ma, Chantal Mathieu, Nestoras Mathioudakis, James B Meigs, Shivani Misra, Viswanathan Mohan, Rinki Murphy, Richard Oram, Katharine R Owen, Susan E Ozanne, Ewan R Pearson, Wei Perng, Toni I Pollin, Rodica Pop-Busui, Richard E Pratley, Leanne M Redman, Maria J Redondo, Rebecca M Reynolds, Robert K Semple, Jennifer L Sherr, Emily K Sims, Arianne Sweeting, Tiinamaija Tuomi, Miriam S Udler, Kimberly K Vesco, Tina Vilsbøll, Robert Wagner, Stephen S Rich, Paul W Franks
Precision medicine is part of the logical evolution of contemporary evidence-based medicine that seeks to reduce errors and optimize outcomes when making medical decisions and health recommendations. Diabetes affects hundreds of millions of people worldwide, many of whom will develop life-threatening complications and die prematurely. Precision medicine can potentially address this enormous problem by accounting for heterogeneity in the etiology, clinical presentation and pathogenesis of common forms of diabetes and risks of complications...
October 5, 2023: Nature Medicine
#22
Loretah Chibaya, Christina F Lusi, Kelly D DeMarco, Griffin I Kane, Meghan L Brassil, Chaitanya N Parikh, Katherine C Murphy, Junhui Li, Tiana E Naylor, Julia Cerrutti, Jessica Peura, Jason R Pitarresi, Lihua Julie Zhu, Katherine A Fitzgerald, Prabhani U Atukorale, Marcus Ruscetti
UNLABELLED: Pancreatic ductal adenocarcinoma has quickly risen to become the 3 rd leading cause of cancer-related death. This is in part due to its fibrotic tumor microenvironment (TME) that contributes to poor vascularization and immune infiltration and subsequent chemo- and immunotherapy failure. Here we investigated an innovative immunotherapy approach combining local delivery of STING and TLR4 innate immune agonists via lipid-based nanoparticles (NPs) co-encapsulation with senescence-inducing RAS-targeted therapies that can remodel the immune suppressive PDAC TME through the senescence-associated secretory phenotype...
September 18, 2023: bioRxiv
#23
JOURNAL ARTICLE
N Ali, T Dhere, J E Bates, J Lorenz, J Janopaul-Naylor, A Schlafstein, P R Patel, J Y Lin
PURPOSE/OBJECTIVE(S): In recent years, there has been a decline in the number of radiation oncology residency applicants. New techniques to recruit students to the field are necessary. Early exposure to oncology care in pre-clinical years may translate to increased student interest in oncology-related fields and improved understanding of oncologic treatment modalities. We propose that a cancer-specific problem-based learning (PBL) case will increase exposure to oncology during pre-clinical years...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#24
JOURNAL ARTICLE
T J Corriher, J Janopaul-Naylor, Y Liu, V R Dhere, N Sebastian, A Weiss, B Hershatter, C P Filson, S A Patel
PURPOSE/OBJECTIVE(S): The 2012 United States Preventive Services Task Force (USPSTF) Grade D recommendation against prostate-specific antigen (PSA) screening has resulted in a shift to higher-stage prostate cancer (PC) at diagnosis. While incidence of low-risk prostate cancer has declined, more men are diagnosed with high-risk disease, and multimodal treatment is often required. The impact of this epidemiologic shift on practice patterns, specifically radical prostatectomy (RP) versus definitive radiation therapy (RT), for men with localized PC at high risk of recurrence is unknown...
October 1, 2023: International Journal of Radiation Oncology, Biology, Physics
#25
REVIEW
Steven R Byrum, Bryan S Frazier, R Dean Grubbs, Gavin J P Naylor, Gareth J Fraser
BACKGROUND: The hammerhead sharks (family Sphyrnidae) are an immediately recognizable group of sharks due to their unique head shape. Though there has long been an interest in hammerhead development, there are currently no explicit staging tables published for any members of the group. The bonnethead Sphyrna tiburo is the smallest member of Sphyrnidae and is abundant in estuarine and nearshore waters in the Gulf of Mexico and Western North Atlantic Ocean. Due to their relative abundance, close proximity to shore, and brief gestation period, it has been possible to collect and document multiple embryonic specimens at progressive stages of development...
September 28, 2023: Developmental Dynamics
#26
RANDOMIZED CONTROLLED TRIAL
Daniel J Green, Gustavo O Silva, Kurt J Smith, Barbara A Maslen, Kay L Cox, Nicola T Lautenschlager, Carmela F Pestell, Philip N Ainslie, Andrew Haynes, Louise H Naylor
INTRODUCTION: Exercise improves vascular function, but it is unclear whether benefits are mediated by traditional cardiovascular risk factors or whether sex differences in training effects exist in older adults. We hypothesized that exercise would improve cardiovascular risk factors, that males and females would benefit similarly, and that improvements in risk factors would correlate with changes in vascular function. METHODS: Seventy-two healthy middle-aged/older adults (age, 62 ± 7 yr; 26%♂) were randomized to a land-walking ( n = 23), water-walking ( n = 25), or a nonexercise control group (C; n = 23)...
February 1, 2024: Medicine and Science in Sports and Exercise
#27
MULTICENTER STUDY
Shania Liu, Jennifer A Stevens, Ashleigh E Collins, Jed Duff, Joanna R Sutherland, Morgan D Oddie, Justine M Naylor, Asad E Patanwala, Benita M Suckling, Jonathan Penm
Opioid analgesics prescribed for the management of acute pain following orthopaedic surgery may lead to unintended long-term opioid use and associated patient harms. This study aimed to examine the prevalence of opioid use at 90 days after elective orthopaedic surgery across major city, regional and rural locations in New South Wales, Australia. We conducted a prospective, observational cohort study of patients undergoing elective orthopaedic surgery at five hospitals from major city, regional, rural, public and private settings between April 2017 and February 2020...
September 2023: Anaesthesia and Intensive Care
#28
JOURNAL ARTICLE
Trey R Naylor, Jessica E Kiss, Adam M Fullenkamp, David K Garon
INTRODUCTION: In special populations, such as Reserve Officers' Training Corps (ROTC) cadets, body composition is used not only as a predictor of fitness but for additional purposes such as qualification for enlistment, load carriage, and duty fulfillment. Body mass index (BMI) is the initial measurement recorded and is considered a representation of health and physical performance capabilities. Personnel exceeding threshold values of body weight based upon their height measurement are typically further evaluated using a circumference-based method that predicts the cadets' percent body fat...
August 11, 2023: Military Medicine
#29
JOURNAL ARTICLE
Maryam Ghaderi Najafabadi, G Kenneth Gray, Li Ren Kong, Komal Gupta, David Perera, Huw Naylor, Joan S Brugge, Ashok R Venkitaraman, Mona Shehata
Germline BRCA2 mutation carriers frequently develop luminal-like breast cancers, but it remains unclear how BRCA2 mutations affect mammary epithelial subpopulations. Here, we report that monoallelic Brca2mut/WT mammary organoids subjected to replication stress activate a transcriptional response that selectively expands Brca2mut/WT luminal cells lacking hormone receptor expression (HR-). While CyTOF analyses reveal comparable epithelial compositions among wildtype and Brca2mut/WT mammary glands, Brca2mut/WT HR- luminal cells exhibit greater organoid formation and preferentially survive and expand under replication stress...
August 25, 2023: Nature Communications
#30
JOURNAL ARTICLE
Victoria O'Connor, Jared A Rowland, Jennifer C Naylor, Anna T Magnante, Katherine M Craig, Holly M Miskey, Sarah L Martindale
OBJECTIVE: Posttraumatic stress disorder (PTSD) symptoms and pain interfere with daily functioning and quality of life for many combat Veterans. As individuals age, pain symptoms tend to increase whereas PTSD symptoms tend to decrease. PTSD symptoms exacerbate pain, but the nature of this relationship across the aging process is unclear. The purpose of this study was to determine how PTSD symptoms affect the association between age and pain intensity. METHODS: Participants in this cross-sectional study included 450 Veterans (80% male) who served after September 11, 2001...
2023: Frontiers in Psychiatry
#31
JOURNAL ARTICLE
J Aalbers, D S Akerib, C W Akerlof, A K Al Musalhi, F Alder, A Alqahtani, S K Alsum, C S Amarasinghe, A Ames, T J Anderson, N Angelides, H M Araújo, J E Armstrong, M Arthurs, S Azadi, A J Bailey, A Baker, J Balajthy, S Balashov, J Bang, J W Bargemann, M J Barry, J Barthel, D Bauer, A Baxter, K Beattie, J Belle, P Beltrame, J Bensinger, T Benson, E P Bernard, A Bhatti, A Biekert, T P Biesiadzinski, H J Birch, B Birrittella, G M Blockinger, K E Boast, B Boxer, R Bramante, C A J Brew, P Brás, J H Buckley, V V Bugaev, S Burdin, J K Busenitz, M Buuck, R Cabrita, C Carels, D L Carlsmith, B Carlson, M C Carmona-Benitez, M Cascella, C Chan, A Chawla, H Chen, J J Cherwinka, N I Chott, A Cole, J Coleman, M V Converse, A Cottle, G Cox, W W Craddock, O Creaner, D Curran, A Currie, J E Cutter, C E Dahl, A David, J Davis, T J R Davison, J Delgaudio, S Dey, L de Viveiros, A Dobi, J E Y Dobson, E Druszkiewicz, A Dushkin, T K Edberg, W R Edwards, M M Elnimr, W T Emmet, S R Eriksen, C H Faham, A Fan, S Fayer, N M Fearon, S Fiorucci, H Flaecher, P Ford, V B Francis, E D Fraser, T Fruth, R J Gaitskell, N J Gantos, D Garcia, A Geffre, V M Gehman, J Genovesi, C Ghag, R Gibbons, E Gibson, M G D Gilchriese, S Gokhale, B Gomber, J Green, A Greenall, S Greenwood, M G D van der Grinten, C B Gwilliam, C R Hall, S Hans, K Hanzel, A Harrison, E Hartigan-O'Connor, S J Haselschwardt, M A Hernandez, S A Hertel, G Heuermann, C Hjemfelt, M D Hoff, E Holtom, J Y-K Hor, M Horn, D Q Huang, D Hunt, C M Ignarra, R G Jacobsen, O Jahangir, R S James, S N Jeffery, W Ji, J Johnson, A C Kaboth, A C Kamaha, K Kamdin, V Kasey, K Kazkaz, J Keefner, D Khaitan, M Khaleeq, A Khazov, I Khurana, Y D Kim, C D Kocher, D Kodroff, L Korley, E V Korolkova, J Kras, H Kraus, S Kravitz, H J Krebs, L Kreczko, B Krikler, V A Kudryavtsev, S Kyre, B Landerud, E A Leason, C Lee, J Lee, D S Leonard, R Leonard, K T Lesko, C Levy, J Li, F-T Liao, J Liao, J Lin, A Lindote, R Linehan, W H Lippincott, R Liu, X Liu, Y Liu, C Loniewski, M I Lopes, E Lopez Asamar, B López Paredes, W Lorenzon, D Lucero, S Luitz, J M Lyle, P A Majewski, J Makkinje, D C Malling, A Manalaysay, L Manenti, R L Mannino, N Marangou, M F Marzioni, C Maupin, M E McCarthy, C T McConnell, D N McKinsey, J McLaughlin, Y Meng, J Migneault, E H Miller, E Mizrachi, J A Mock, A Monte, M E Monzani, J A Morad, J D Morales Mendoza, E Morrison, B J Mount, M Murdy, A St J Murphy, D Naim, A Naylor, C Nedlik, C Nehrkorn, F Neves, A Nguyen, J A Nikoleyczik, A Nilima, J O'Dell, F G O'Neill, K O'Sullivan, I Olcina, M A Olevitch, K C Oliver-Mallory, J Orpwood, D Pagenkopf, S Pal, K J Palladino, J Palmer, M Pangilinan, N Parveen, S J Patton, E K Pease, B Penning, C Pereira, G Pereira, E Perry, T Pershing, I B Peterson, A Piepke, J Podczerwinski, D Porzio, S Powell, R M Preece, K Pushkin, Y Qie, B N Ratcliff, J Reichenbacher, L Reichhart, C A Rhyne, A Richards, Q Riffard, G R C Rischbieter, J P Rodrigues, A Rodriguez, H J Rose, R Rosero, P Rossiter, T Rushton, G Rutherford, D Rynders, J S Saba, D Santone, A B M R Sazzad, R W Schnee, P R Scovell, D Seymour, S Shaw, T Shutt, J J Silk, C Silva, G Sinev, K Skarpaas, W Skulski, R Smith, M Solmaz, V N Solovov, P Sorensen, J Soria, I Stancu, M R Stark, A Stevens, T M Stiegler, K Stifter, R Studley, B Suerfu, T J Sumner, P Sutcliffe, N Swanson, M Szydagis, M Tan, D J Taylor, R Taylor, W C Taylor, D J Temples, B P Tennyson, P A Terman, K J Thomas, D R Tiedt, M Timalsina, W H To, A Tomás, Z Tong, D R Tovey, J Tranter, M Trask, M Tripathi, D R Tronstad, C E Tull, W Turner, L Tvrznikova, U Utku, J Va'vra, A Vacheret, A C Vaitkus, J R Verbus, E Voirin, W L Waldron, A Wang, B Wang, J J Wang, W Wang, Y Wang, J R Watson, R C Webb, A White, D T White, J T White, R G White, T J Whitis, M Williams, W J Wisniewski, M S Witherell, F L H Wolfs, J D Wolfs, S Woodford, D Woodward, S D Worm, C J Wright, Q Xia, X Xiang, Q Xiao, J Xu, M Yeh, J Yin, I Young, P Zarzhitsky, A Zuckerman, E A Zweig
The LUX-ZEPLIN experiment is a dark matter detector centered on a dual-phase xenon time projection chamber operating at the Sanford Underground Research Facility in Lead, South Dakota, USA. This Letter reports results from LUX-ZEPLIN's first search for weakly interacting massive particles (WIMPs) with an exposure of 60 live days using a fiducial mass of 5.5 t. A profile-likelihood ratio analysis shows the data to be consistent with a background-only hypothesis, setting new limits on spin-independent WIMP-nucleon, spin-dependent WIMP-neutron, and spin-dependent WIMP-proton cross sections for WIMP masses above 9 GeV/c^{2}...
July 28, 2023: Physical Review Letters
#32
JOURNAL ARTICLE
Nikhil Sebastian, Subir Goyal, Yuan Liu, James R Janopaul-Naylor, Pretesh R Patel, Vishal R Dhere, Sheela Hanasoge, Jay W Shelton, Karen D Godette, Ashesh B Jani, Bruce Hershatter, Benjamin Fischer-Valuck, Sagar A Patel
IMPORTANCE: Very high-risk (VHR) prostate cancer is an aggressive substratum of high-risk prostate cancer, characterized by high prostate-specific antigen levels, high Gleason score, and/or advanced T category. Contemporary management paradigms involve advanced molecular imaging and multimodal treatment with intensified prostate-directed or systemic treatment-resources more readily available at high-volume centers. OBJECTIVE: To examine radiation facility case volume and overall survival (OS) in men with VHR prostate cancer...
August 1, 2023: JAMA Network Open
#33
JOURNAL ARTICLE
James R Janopaul-Naylor, Taylor J Corriher, Jeffrey Switchenko, Sheela Hanasoge, Ashanda Esdaille, Brandon A Mahal, Christopher P Filson, Sagar A Patel
BACKGROUND: Delayed access to care may contribute to disparities in prostate cancer (PCa). The Affordable Care Act (ACA) aimed at increasing access and reducing healthcare disparities, but its impact on timely treatment initiation for PCa men is unknown. METHODS: Men with intermediate- and high-risk PCa diagnosed 2010-2016 and treated with curative surgery or radiotherapy were identified in the National Cancer Database. Multivariable logistic regression modeled the effect of race and insurance type on treatment delay >180 days after diagnosis...
August 3, 2023: Cancer Medicine
#34
JOURNAL ARTICLE
David R Lisgarten, Rex A Palmer, Jon B Cooper, Claire E Naylor, Rosemary C Talbert, Brendan J Howlin, John N Lisgarten, Janez Konc, Shabir Najmudin, Carina M C Lobley
The crystal structure of orthorhombic Bovine Pancreatic Ribonuclease A has been determined to 0.85 Å resolution using low temperature, 100 K, synchrotron X-ray data collected at 16000 keV (λ = 0.77 Å). This is the first ultra-high-resolution structure of a native form of Ribonuclease A to be reported. Refinement carried out with anisotropic displacement parameters, stereochemical restraints, inclusion of H atoms in calculated positions, five [Formula: see text] moieties, eleven ethanol molecules and 293 water molecules, converged with final R values of R1(Free) = 0...
July 27, 2023: BMC chemistry
#35
JOURNAL ARTICLE
S Liu, A Athar, D Quach, A E Patanwala, J M Naylor, J A Stevens, N Levy, R D Knaggs, D N Lobo, J Penm
Prescription of modified-release opioids for acute postoperative pain is widespread despite evidence to show their use may be associated with an increased risk of adverse effects. This systematic review and meta-analysis aimed to examine the available evidence on the safety and efficacy of modified-release, compared with immediate-release, oral opioids for postoperative pain in adults. We searched five electronic databases from 1 January 2003 to 1 January 2023. Published randomised clinical trials and observational studies on adults who underwent surgery which compared those who received oral modified-release opioids postoperatively with those receiving oral immediate-release opioids were included...
October 2023: Anaesthesia
#36
JOURNAL ARTICLE
Yiling Tang, Beatrix Algurén, Chelsea Pelletier, Patti-Jean Naylor, Guy Faulkner
BACKGROUND: Physical literacy (PL) is considered an important determinant of children's physical activity through which health benefits may be derived. The purpose of this study is to describe a sample of Canadian children's baseline levels of PL and movement behaviors, and explore whether the associations between PL and their mental wellbeing, if any, are mediated by moderate-to-vigorous physical activity (MVPA). METHODS: All grade two children in 14 elementary schools in the West Vancouver School District, Canada were invited to participate in a two-year longitudinal project...
June 29, 2023: BMC Public Health
#37
JOURNAL ARTICLE
S Liu, A E Patanwala, J M Naylor, N Levy, R Knaggs, J A Stevens, B Bugeja, D Begley, K E Khor, E Lau, R Allen, S Adie, J Penm
Modified-release opioids are often prescribed for the management of moderate to severe acute pain following total hip and knee arthroplasty, despite recommendations against their use due to increasing concerns regarding harm. The primary objective of this multicentre study was to examine the impact of modified-release opioid use on the incidence of opioid-related adverse events compared with immediate-release opioid use, among adult inpatients following total hip or knee arthroplasty. Data for total hip and knee arthroplasty inpatients receiving an opioid analgesic for postoperative analgesia during hospitalisation were collected from electronic medical records of three tertiary metropolitan hospitals in Australia...
June 26, 2023: Anaesthesia
#38
JOURNAL ARTICLE
Neal S McCall, James R Janopaul-Naylor, H Scott McGinnis, Aparna H Kesarwala, Sibo Tian, William A Stokes, Joseph W Shelton, Conor E Steuer, Jennifer W Carlisle, Ticiana A Leal, Suresh S Ramalingam, Jeffrey D Bradley, Kristin A Higgins
BACKGROUND: The PACIFIC trial established consolidative durvalumab after concurrent chemoradiation as standard-of-care in patients with stage III or unresectable non-small cell lung cancer (NSCLC). Black patients, however, comprised just 2% (n = 14) of randomized patients in this trial, warranting real-world evaluation of the PACIFIC regimen in these patients. METHODS: This single-institution, multi-site study included 105 patients with unresectable stage II/III NSCLC treated with concurrent chemoradiation followed by durvalumab between 2017 and 2021...
June 24, 2023: Cancer
#39
JOURNAL ARTICLE
Laia Josa-Culleré, Sébastien R G Galan, Thomas J Cogswell, Thomas R Jackson, Morgan Jay-Smith, Laura Mola, Christopher R Greaves, Tom S Carter, Katrina S Madden, Sophie Trott, Douzi Zhang, Carole J R Bataille, Stephen G Davies, Paresh Vyas, Thomas A Milne, Alan Naylor, Graham M Wynne, Angela J Russell
Acute myeloid leukaemia (AML) is an aggressive type of leukaemia with low rates of long-term survival. While the current standard of care is based on cytotoxic chemotherapy, a promising emerging approach is differentiation therapy. However, most current differentiating agents target specific mutations and are effective only in certain patient subtypes. To identify agents which may be effective in wider population cohorts, we performed a phenotypic screen with the myeloid marker CD11b and identified a compound series that was able to differentiate AML cell lines in vitro regardless of their mutation status...
May 26, 2023: European Journal of Medicinal Chemistry
#40
MULTICENTER STUDY
Shania Liu, Jennifer A Stevens, Ashleigh E Collins, Jed Duff, Joanna R Sutherland, Morgan D Oddie, Justine M Naylor, Asad E Patanwala, Benita M Suckling, Jonathan Penm
Opioid analgesics are commonly used by patients awaiting orthopaedic surgery, and preoperative opioid use is associated with a greater burden of postoperative pain, suboptimal surgical outcomes and higher healthcare costs. This study aimed to examine the prevalence of total opioid use before elective orthopaedic surgery with a focus on regional and rural hospitals in New South Wales, Australia. This was a cross-sectional, observational study of patients undergoing orthopaedic surgery conducted between April 2017 and November 2019 across five hospitals that included a mix of metropolitan, regional, rural, private and public settings...
September 2023: Anaesthesia and Intensive Care
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