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A.R. Naylor

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https://www.readbyqxmd.com/read/28268070/post-carotid-endarterectomy-hypertension-part-1-association-with-pre-operative-clinical-imaging-and-physiological-parameters
#1
J E Newman, M J Bown, R D Sayers, J P Thompson, T G Robinson, B Williams, R Panerai, P Lacy, A R Naylor
OBJECTIVE/BACKGROUND: Post-endarterectomy hypertension (PEH) is a well recognised, but poorly understood, phenomenon after carotid endarterectomy (CEA) that is associated with post-operative intracranial haemorrhage, hyperperfusion syndrome, and cardiac complications. The aim of the current study was to identify pre-operative clinical, imaging, and physiological parameters associated with PEH. METHODS: In total, 106 CEA patients undergoing CEA under general anaesthesia underwent pre-operative evaluation of 24 hour ambulatory arterial blood pressure (BP), baroreceptor sensitivity, cerebral autoregulation, and transcranial Doppler measurement of cerebral blood flow velocity (CBFv) and pulsatility index...
March 3, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28249899/kr%C3%A3-ppel-like-transcription-factor-klf10-suppresses-tgf%C3%AE-induced-epithelial-to-mesenchymal-transition-via-a-negative-feedback-mechanism
#2
Vivek Kumar Mishra, Malayannan Subramaniam, Vijayalakshmi Kari, Kevin S Pitel, Simon J Baumgart, Ryan M Naylor, Sankari Nagarajan, Florian Wegwitz, Volker Ellenrieder, John R Hawse, Steven A Johnsen
TGFβ-SMAD signaling exerts a contextual effect that suppresses malignant growth early in epithelial tumorigenesis but promotes metastasis at later stages. Longstanding challenges in resolving this functional dichotomy may uncover new strategies to treat advanced carcinomas. The Krüppel-like transcription factor KLF10 is a pivotal effector of TGFβ/SMAD signaling that mediates anti-proliferative effects of TGFβ. In this study, we show how KLF10 opposes the pro-metastatic effects of TGFβ by limiting its ability to induce epithelial-to-mesenchymal transition (EMT)...
March 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28215073/identification-of-highly-specific-diversity-oriented-synthesis-derived-inhibitors-of-clostridium-difficile
#3
Jeremy R Duvall, Leanne Bedard, Adel M Naylor-Olsen, Abigail L Manson, Joshua A Bittker, Wenye Sun, Mark E Fitzgerald, Zhenmin He, Maurice D Lee, Jean-Charles Marie, Giovanni Muncipinto, Diane Rush, Deming Xu, Huisheng Xu, Mingliang Zhang, Ashlee M Earl, Michelle A Palmer, Michael A Foley, Joseph P Vacca, Christina A Scherer
In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options currently exist, many of which result in disease relapse. We sought to identify molecules specifically targeting C. difficile in high-throughput screens of our diversity-oriented synthesis compound collection. We identified two scaffolds with apparently novel mechanisms of action that selectively target C...
March 7, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28129565/cannabis-use-disorder-and-suicide-attempts-in-iraq-afghanistan-era-veterans
#4
Nathan A Kimbrel, Amie R Newins, Eric A Dedert, Elizabeth E Van Voorhees, Eric B Elbogen, Jennifer C Naylor, H Ryan Wagner, Mira Brancu, Jean C Beckham, Patrick S Calhoun
The objective of the present research was to examine the association between lifetime cannabis use disorder (CUD), current suicidal ideation, and lifetime history of suicide attempts in a large and diverse sample of Iraq/Afghanistan-era veterans (N = 3233) using a battery of well-validated instruments. As expected, CUD was associated with both current suicidal ideation (OR = 1.683, p = 0.008) and lifetime suicide attempts (OR = 2.306, p < 0.0001), even after accounting for the effects of sex, posttraumatic stress disorder, depression, alcohol use disorder, non-cannabis drug use disorder, history of childhood sexual abuse, and combat exposure...
January 5, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28114993/an-equivalence-study-are-patient-completed-and-telephone-interview-equivalent-modes-of-administration-for-the-euroqol-survey
#5
R Chatterji, J M Naylor, I A Harris, E Armstrong, E Davidson, R Ekmejian, J Descallar
BACKGROUND: To determine if the EuroQol Health Related Quality of Life survey produces equivalent results when administered by phone interview or patient-completed forms. METHODS: People awaiting hip or knee arthroplasty at a major metropolitan hospital participated. They were randomly assigned to receive the EuroQol Health Related Quality of Life survey via telephone, followed by a patient completed form 1 week later, or vice versa. Equivalence was determined using two one-sided tests (TOST) based on minimal clinically-important differences for the visual analogue scale (VAS) and the summary Utility Index...
January 23, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28094166/carotid-stenting-prior-to-coronary-bypass-surgery-an-updated-systematic-review-and-meta-analysis
#6
REVIEW
K I Paraskevas, S Nduwayo, A N Saratzis, A R Naylor
OBJECTIVES: The aim was to determine 30-day outcomes in patients with concurrent carotid and cardiac disease who underwent carotid artery stenting (CAS) followed by coronary artery bypass grafting (CABG). METHODS: This was a systematic review with searches of PubMed/Medline, Embase, and Cochrane databases. "Same-day" procedures involved CAS + CABG being performed on the same day, and "staged" interventions involved at least 1 day's delay between undergoing CAS and then CABG...
January 13, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28093634/international-osteoporosis-foundation-and-european-calcified-tissue-society-working-group-recommendations-for-the-screening-of-adherence-to-oral-bisphosphonates
#7
A Diez-Perez, K E Naylor, B Abrahamsen, D Agnusdei, M L Brandi, C Cooper, E Dennison, E F Eriksen, D T Gold, N Guañabens, P Hadji, M Hiligsmann, R Horne, R Josse, J A Kanis, B Obermayer-Pietsch, D Prieto-Alhambra, J-Y Reginster, R Rizzoli, S Silverman, M C Zillikens, R Eastell
Adherence to oral bisphosphonates is low. A screening strategy is proposed based on the response of biochemical markers of bone turnover after 3 months of therapy. If no change is observed, the clinician should reassess the adherence to the treatment and also other potential issues with the drug. INTRODUCTION: Low adherence to oral bisphosphonates is a common problem that jeopardizes the efficacy of treatment of osteoporosis. No clear screening strategy for the assessment of compliance is widely accepted in these patients...
March 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28093409/deuterater-a-tool-for-quantifying-peptide-isotope-precision-and-kinetic-proteomics
#8
Bradley C Naylor, Michael T Porter, Elise Wilson, Adam Herring, Spencer Lofthouse, Austin Hannemann, Stephen R Piccolo, Alan L Rockwood, John C Price
MOTIVATION: Using mass spectrometry to measure the concentration and turnover of the individual proteins in a proteome, enables the calculation of individual synthesis and degradation rates for each protein. Software to analyze concentration is readily available, but software to analyze turnover is lacking. Data analysis workflows typically don't access the full breadth of information about instrument precision and accuracy that is present in each peptide isotopic envelope measurement...
January 16, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28075132/discovery-of-imidazo-1-2-a-pyridine-ethers-and-squaramides-as-selective-and-potent-inhibitors-of-mycobacterial-adenosine-triphosphate-atp-synthesis
#9
Subramanyam J Tantry, Shankar D Markad, Vikas Shinde, Jyothi Bhat, Gayathri Balakrishnan, Amit K Gupta, Anisha Ambady, Anandkumar Raichurkar, Chaitanyakumar Kedari, Sreevalli Sharma, Naina V Mudugal, Ashwini Narayan, C N Naveen Kumar, Robert Nanduri, Sowmya Bharath, Jitendar Reddy, Vijender Panduga, K R Prabhakar, Karthikeyan Kandaswamy, Ramanatha Saralaya, Parvinder Kaur, Neela Dinesh, Supreeth Guptha, Kirsty Rich, David Murray, Helen Plant, Marian Preston, Helen Ashton, Darren Plant, Jarrod Walsh, Peter Alcock, Kathryn Naylor, Matthew Collier, James Whiteaker, Robert E McLaughlin, Meenakshi Mallya, Manoranjan Panda, Suresh Rudrapatna, Vasanthi Ramachandran, Radha Shandil, Vasan K Sambandamurthy, Khisi Mdluli, Christopher B Cooper, Harvey Rubin, Takahiro Yano, Pravin Iyer, Shridhar Narayanan, Stefan Kavanagh, Kakoli Mukherjee, V Balasubramanian, Vinayak P Hosagrahara, Suresh Solapure, Sudha Ravishankar, Shahul Hameed P
The approval of bedaquiline to treat tuberculosis has validated adenosine triphosphate (ATP) synthase as an attractive target to kill Mycobacterium tuberculosis (Mtb). Herein, we report the discovery of two diverse lead series imidazo[1,2-a]pyridine ethers (IPE) and squaramides (SQA) as inhibitors of mycobacterial ATP synthesis. Through medicinal chemistry exploration, we established a robust structure-activity relationship of these two scaffolds, resulting in nanomolar potencies in an ATP synthesis inhibition assay...
February 3, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/27988577/-i-galeus-i-i-corriganae-i-sp-nov-a-new-species-of-deepwater-catshark-carcharhiniformes-pentanchidae-from-papua-new-guinea
#10
William T White, Ralph R Mana, Gavin J P Naylor
A new species of catshark, provisionally placed in the genus Galeus, is described from Papua New Guinea based on 7 specimens collected during recent deepwater surveys of the region. The new species, Galeus corriganae, is closest to G. priapus from New Caledonia and G. gracilis from northwestern Australia but differs in several morphological characters. A reclassification of the catshark groups is required to revise the familial and generic arrangement of the group.
December 6, 2016: Zootaxa
https://www.readbyqxmd.com/read/27932527/mechanisms-of-in-vivo-ribosome-maintenance-change-in-response-to-nutrient-signals
#11
Andrew D Mathis, Bradley C Naylor, Richard H Carson, Eric Evans, Justin Harwell, Jared Knecht, Eric Hexem, Fredrick F Peelor, Benjamin F Miller, Karyn L Hamilton, Mark K Transtrum, Benjamin T Bikman, John C Price
Control of protein homeostasis is fundamental to the health and longevity of all organisms. Because the rate of protein synthesis by ribosomes is a central control point in this process, regulation, and maintenance of ribosome function could have amplified importance in the overall regulatory circuit. Indeed, ribosomal defects are commonly associated with loss of protein homeostasis, aging, and disease (1-4), whereas improved protein homeostasis, implying optimal ribosomal function, is associated with disease resistance and increased lifespan (5-7)...
February 2017: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27916543/rapid-assessment-of-tetanus-vaccine-induced-immunity-in-bangladesh-and-the-gambia
#12
Girija Ramakrishnan, Marcia Wright, Masud Alam, Caitlin Naylor, Mamun Kabir, Ayesha Zerin, Tahsin Ferdous, Karl Pedersen, Branwen J Hennig, Jeffrey R Donowitz, Rita Wegmuller, Rashidul Haque, William A Petri, Joel Herbein, Carol A Gilchrist
We have developed recombinant fragment C based rapid point of care dipstick devices to assess tetanus immunization status using plasma or whole blood. The devices demonstrated specificity of 0.90 and sensitivity of 0.90 (whole blood)/0.94 (plasma) at field sites in Bangladesh and The Gambia when compared to a commercial ELISA with the immune cut-off titer set as ≥0.1IU/mL.
March 2017: Diagnostic Microbiology and Infectious Disease
https://www.readbyqxmd.com/read/27910342/modifications-to-the-synthetic-aperture-microwave-imaging-diagnostic
#13
K J Brunner, J C Chorley, N A Dipper, G Naylor, R M Sharples, G Taylor, D A Thomas, R G L Vann
The synthetic aperture microwave imaging diagnostic has been operating on the MAST experiment since 2011. It has provided the first 2D images of B-X-O mode conversion windows and showed the feasibility of conducting 2D Doppler back-scattering experiments. The diagnostic heavily relies on field programmable gate arrays to conduct its work. Recent successes and newly gained experience with the diagnostic have led us to modify it. The enhancements will enable pitch angle profile measurements, O and X mode separation, and the continuous acquisition of 2D DBS data...
November 2016: Review of Scientific Instruments
https://www.readbyqxmd.com/read/27821153/methods-for-estimating-the-burden-of-antimicrobial-resistance-a-systematic-literature-review-protocol
#14
Nichola R Naylor, Sachin Silva, Kavian Kulasabanathan, Rifat Atun, Nina Zhu, Gwenan M Knight, Julie Robotham
BACKGROUND: Estimates of the burden of antimicrobial resistance (AMR) are needed to ascertain AMR impact, to evaluate interventions, and to allocate resources efficiently. Recent studies have estimated health, cost, and economic burden relating to AMR, with outcomes of interest ranging from drug-bug resistance impact on mortality in a hospital setting to total economic impact of AMR on the global economy. However, recent collation of this information has been largely informal, with no formal quality assessment of the current evidence base (e...
November 8, 2016: Systematic Reviews
https://www.readbyqxmd.com/read/27811742/rhinobatos-manai-sp-nov-a-new-species-of-guitarfish-rhinopristiformes-%C3%A2-rhinobatidae-from-new-ireland-papua-new-guinea
#15
William T White, Peter R Last, Gavin J P Naylor
A new species of guitarfish (Rhinobatos) is described based on a single specimen collected in 2014 from off New Ireland in Papua New Guinea. This specimen represents the first record of the family Rhinobatidae in Papua New Guinean waters. Based on molecular data, the new species appears to be most similar to Rhinobatos whitei (Philippines) and Rhinobatos sainsburyi (northern Australia), but is distinguished based on its coloration, morphology and certain meristic characters.
October 18, 2016: Zootaxa
https://www.readbyqxmd.com/read/27676634/dopaminergic-contributions-to-working-memory-related-brain-activation-in-postmenopausal-women
#16
Julie A Dumas, Christopher G Filippi, Paul A Newhouse, Magdalena R Naylor
OBJECTIVE: The current study examined the effects of pharmacologic dopaminergic manipulations on working memory-related brain activation in postmenopausal women to further understand the neurochemistry underlying cognition after menopause. METHODS: Eighteen healthy postmenopausal women, mean age 55.21 years, completed three study days with dopaminergic drug challenges during which they performed a functional magnetic resonance imaging visual verbal N-back test of working memory...
February 2017: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/27624720/minimal-important-improvement-thresholds-for-the-six-minute-walk-test-in-a-knee-arthroplasty-cohort-triangulation-of-anchor-and-distribution-based-methods
#17
J M Naylor, K Mills, M Buhagiar, R Fortunato, R Wright
BACKGROUND: The 6-minute walk test (6MWT) is a commonly used metric for measuring change in mobility after knee arthroplasty, however, what is considered an improvement after surgery has not been defined. The determination of important change in an outcome assessment tool is controversial and may require more than one approach. This study, nested within a combined randomised and observational trial, aimed to define a minimal important improvement threshold for the 6MWT in a knee arthroplasty cohort through a triangulation of methods including patient-perceived anchor-based thresholds and distribution-based thresholds...
September 13, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27609040/functional-in-vitro-tension-measurements-of-fascial-tissue-a-novel-modified-superfusion-approach
#18
R Schleip, W Klingler, S Wearing, I Naylor, M Zuegel, K Hoppe
INTRODUCTION: While two laboratory techniques are commonly used to assess the tensile properties of muscle tissue, emerging evidence suggests that the fascial components of these tissues also serve an active role in force generation. Hence, we investigated whether these techniques are sensitive for assessment of fascial micromechanics. METHODS: Force measurements on dissected fascial tissue were performed either using the classical immersion organ bath or using an improved superfusion approach simulating pulsed pharmacological triggers...
September 7, 2016: Journal of Musculoskeletal & Neuronal Interactions
https://www.readbyqxmd.com/read/27601687/bed-utilisation-and-increased-risk-of-clostridium-difficile-infections-in-acute-hospitals-in-england-in-2013-2014
#19
Venanzio Vella, Paul P Aylin, Luke Moore, Alice King, Nichola R Naylor, Gabriel J C Birgand, Hannah Lishman, Alison Holmes
BACKGROUND: The study aimed to identify thresholds for hospital bed utilisation which are independently associated with significantly higher risks for Clostridium difficile infections (CDI) in acute hospitals in England. METHOD: A retrospective analysis was carried out on reported data from the English National Health Service (NHS) for the financial year 2013/2014. Reported rates of CDI were used as a proxy for hospital infection rates in acute NHS hospital trusts...
September 6, 2016: BMJ Quality & Safety
https://www.readbyqxmd.com/read/27597652/treatment-of-inflammatory-arthritis-via-targeting-of-tristetraprolin-a-master-regulator-of-pro-inflammatory-gene-expression
#20
E A Ross, A J Naylor, J D O'Neil, T Crowley, M L Ridley, J Crowe, T Smallie, T J Tang, J D Turner, L V Norling, S Dominguez, H Perlman, N M Verrills, G Kollias, M P Vitek, A Filer, C D Buckley, J L Dean, A R Clark
OBJECTIVES: Tristetraprolin (TTP), a negative regulator of many pro-inflammatory genes, is strongly expressed in rheumatoid synovial cells. The mitogen-activated protein kinase (MAPK) p38 pathway mediates the inactivation of TTP via phosphorylation of two serine residues. We wished to test the hypothesis that these phosphorylations contribute to the development of inflammatory arthritis, and that, conversely, joint inflammation may be inhibited by promoting the dephosphorylation and activation of TTP...
September 5, 2016: Annals of the Rheumatic Diseases
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