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A.R. Naylor

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https://www.readbyqxmd.com/read/29306765/distal-myopathy-due-to-bicd2-mutations
#1
P V S Souza, W B V R Pinto, Lais Uyeda Aivazoglou, Fabiano Nassar Cardoso, André Yui Aihara, André Fukunishi Yamada, Fernando George Monteiro Naylor, A R C Fernandes, Acary Souza Bulle Oliveira
No abstract text is available yet for this article.
December 29, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29242233/quantum-liquid-droplets-in-a-mixture-of-bose-einstein-condensates
#2
C R Cabrera, L Tanzi, J Sanz, B Naylor, P Thomas, P Cheiney, L Tarruell
Quantum droplets are small clusters of atoms self-bound by the balance of attractive and repulsive forces. Here we report on the observation of droplets solely stabilized by contact interactions in a mixture of two Bose-Einstein condensates. We demonstrate that they are several orders of magnitude more dilute than liquid helium by directly measuring their size and density via in situ imaging. We show that the droplets are stablized against collapse by quantum fluctuations and that they require a minimum atom number to be stable...
December 14, 2017: Science
https://www.readbyqxmd.com/read/29242104/structural-network-differences-in-chronic-muskuloskeletal-pain-beyond-fractional-anisotropy
#3
James H Bishop, Marina Shpaner, Antoni Kubicki, Sarah Clements, Richard Watts, Magdalena R Naylor
Chronic musculoskeletal pain is a condition that influences central nervous system structure. In this study, we combined novel structural neuroimaging techniques, using well-validated software packages including FSL, Mrtrix3, and DSI Studio, to characterize brain grey (GM) and white matter (WM) differences in chronic musculoskeletal pain participants (n = 74), compared to age-matched pain-free controls (n = 31). In participants with chronic pain, we identified significantly higher volume in subcortical GM structures using voxel-based morphometry (FSLVBM)...
December 11, 2017: NeuroImage
https://www.readbyqxmd.com/read/29205704/hypoglycemia-in-sulfonylurea-treated-kcnj11-neonatal-diabetes-mild-moderate-symptomatic-episodes-occur-infrequently-but-none-involving-unconsciousness-or-seizures
#4
Monica S Lanning, David Carmody, Łukasz Szczerbiński, Lisa R Letourneau, Rochelle N Naylor, Siri Atma W Greeley
BACKGROUND: Neonatal diabetes mellitus (NDM) caused by mutations in KCNJ11 can be successfully treated with high dose oral sulfonylureas; however, little data is available on the risk of hypoglycemia. OBJECTIVE: To determine the frequency, severity, and clinical significance of hypoglycemia in KCNJ11-related NDM. METHODS: Utilizing the University of Chicago Monogenic Diabetes Registry, parents completed an online questionnaire addressing hypoglycemia...
December 5, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/29193979/when-enough-is-enough-decision-criteria-for-moving-a-known-drug-into-clinical-testing-for-a-new-indication-in-the-absence-of-preclinical-efficacy-data
#5
Jill M Pulley, Rebecca N Jerome, Nicole M Zaleski, Jana K Shirey-Rice, Andrea J Pruijssers, Robert R Lavieri, Somsundaram N Chettiar, Helen M Naylor, David M Aronoff, David A Edwards, Colleen M Niswender, Laura L Dugan, Leslie J Crofford, Gordon R Bernard, Kenneth J Holroyd
Many animal models of disease are suboptimal in their representation of human diseases and lack of predictive power in the success of pivotal human trials. In the context of repurposing drugs with known human safety, it is sometimes appropriate to conduct the "last experiment first," that is, progressing directly to human investigations. However, there are not accepted criteria for when to proceed straight to humans to test a new indication. We propose a specific set of criteria to guide the decision-making around when to initiate human proof of principle without preclinical efficacy studies in animal models...
December 1, 2017: Assay and Drug Development Technologies
https://www.readbyqxmd.com/read/29117179/a-mutation-in-the-viral-sensor-2-5-oligoadenylate-synthetase-2-causes-failure-of-lactation
#6
Samantha R Oakes, David Gallego-Ortega, Prudence M Stanford, Simon Junankar, Wendy Wing Yee Au, Zoya Kikhtyak, Anita von Korff, Claudio M Sergio, Andrew M K Law, Lesley E Castillo, Stephanie L Allerdice, Adelaide I J Young, Catherine Piggin, Belinda Whittle, Edward Bertram, Matthew J Naylor, Daniel L Roden, Jesse Donovan, Alexei Korennykh, Christopher C Goodnow, Moira K O'Bryan, Christopher J Ormandy
We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused post-partum failure of lactation in healthy mice with otherwise normally developed mammary glands, characterized by greatly reduced milk protein synthesis coupled with epithelial cell death, inhibition of proliferation and a robust interferon response. Expression of mutant but not wild type Oas2 in cultured HC-11 or T47D mammary cells recapitulated the phenotypic and transcriptional effects observed in the mouse...
November 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29095386/torticollis-and-fever-in-a-young-boy-a-unique-presentation-of-cat-scratch-disease-with-vertebral-osteomyelitis-and-epidural-phlegmon
#7
Jason R Rafferty, Elizabeth Janopaul-Naylor, Jeffrey Riese
Cat-scratch disease-associated vertebral osteomyelitis and epidural involvement are rare and may manifest with nonspecific chronic symptoms in children, such as fever or torticollis. We present only the fourth case in the literature describing epidural involvement in an immunocompetent boy presenting with fever, torticollis, and indiscriminate left upper back tenderness. Bartonella henselae serologies are important to consider because such atypical complications often are responsive to conservative management with antibiotics...
October 31, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29073499/management-of-major-vascular-injury-during-pedicle-screw-instrumentation-of-thoracolumbar-spine
#8
Aleem K Mirza, Mohammed Ali Alvi, Ryan M Naylor, Panagiotis Kerezoudis, William E Krauss, Michelle J Clarke, Daniel L Shepherd, Ahmad Nassr, Randall R DeMartino, Mohamad Bydon
OBJECTIVES: Vascular injury is a rare complication of spinal instrumentation. Presentation can vary from immediate hemorrhage to pseudoaneurysm formation. In the literature, surgical approach to repair has varied based on anatomy, acuity of diagnosis, infection, and available technology. In this manuscript, we aim to describe our institutional experience with vascular injuries in thoraco-lumbar spine surgery. PATIENTS AND METHODS: We report our institutional experience of three cases of vascular injury secondary to pedicle screw misplacement and their management, as well as a review of the literature...
October 16, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29035678/the-relationships-between-impact-location-and-post-impact-ball-speed-bat-torsion-and-ball-direction-in-cricket-batting
#9
C Peploe, S A McErlain-Naylor, A R Harland, M A King
Three-dimensional kinematic data of bat and ball were recorded for 239 individual shots performed by twenty batsmen ranging from club to international standard. The impact location of the ball on the bat face was determined and assessed against the resultant instantaneous post-impact ball speed and measures of post-impact bat torsion and ball direction. Significant negative linear relationships were found between post-impact ball speed and the absolute distance of impact from the midline medio-laterally and sweetspot longitudinally...
October 16, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29034571/association-between-subclinical-thyroid-dysfunction-and-change-in-bone-mineral-density-in-prospective-cohorts
#10
D Segna, D C Bauer, M Feller, C Schneider, H A Fink, C E Aubert, T-H Collet, B R da Costa, K Fischer, R P Peeters, A R Cappola, M R Blum, H A van Dorland, J Robbins, K Naylor, R Eastell, A G Uitterlinden, F Rivadeneira Ramirez, A Gogakos, J Gussekloo, G R Williams, A Schwartz, J A Cauley, D A Aujesky, H A Bischoff-Ferrari, N Rodondi
BACKGROUND: Subclinical hyperthyroidism (SHyper) has been associated with increased risk of hip and other fractures, but the linking mechanisms remain unclear. OBJECTIVE: To investigate the association between subclinical thyroid dysfunction and bone loss. METHODS: Individual participant data analysis was performed after a systematic literature search in MEDLINE/EMBASE (1946-2016). Two reviewers independently screened and selected prospective cohorts providing baseline thyroid status and serial bone mineral density (BMD) measurements...
January 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28930627/fitness-body-composition-and-vascular-health-in-adolescent-and-young-adult-survivors-of-paediatric-brain-cancer-and-cranial-radiotherapy
#11
Treya M Long, Shoshana R Rath, Tessa D Maroni, Karen E Wallman, Helen C Atkinson, Nicholas G Gottardo, Catherine H Cole, Catherine S Choong, Louise H Naylor
Background Survivors of paediatric brain cancer and/or cranial radiotherapy (CRT) are at an increased risk of developing serious comorbidities. Established risk factors for chronic disease include central obesity, endothelial abnormalities and diminished fitness. Objectives Here we characterised anthropometry, body composition, bone mineral density (BMD), heart rate (HR), blood pressure (BP), endothelial function, muscular strength and endurance and aerobic fitness in adolescent and young adult (AYA) survivors...
September 20, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28888385/something-old-something-new-something-borrowed-and-something-blue
#12
EDITORIAL
A R Naylor, M Vega de Ceniga
No abstract text is available yet for this article.
October 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28851594/editor-s-choice-management-of-atherosclerotic-carotid-and-vertebral-artery-disease-2017-clinical-practice-guidelines-of-the-european-society-for-vascular-surgery-esvs
#13
Writing Group, A R Naylor, J-B Ricco, G J de Borst, S Debus, J de Haro, A Halliday, G Hamilton, J Kakisis, S Kakkos, S Lepidi, H S Markus, D J McCabe, J Roy, H Sillesen, J C van den Berg, F Vermassen, Esvs Guidelines Committee, P Kolh, N Chakfe, R J Hinchliffe, I Koncar, J S Lindholt, M Vega de Ceniga, F Verzini, Esvs Guideline Reviewers, J Archie, S Bellmunt, A Chaudhuri, M Koelemay, A-K Lindahl, F Padberg, M Venermo
No abstract text is available yet for this article.
January 2018: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28802119/gambling-with-antibiotics-a-novel-approach-for-exploring-antibiotic-consumption-decision-making
#14
N R Naylor, I Uchegbu, A Chatterjee, J V Robotham
No abstract text is available yet for this article.
October 2017: Public Health
https://www.readbyqxmd.com/read/28743728/imaging-regiospecific-lipid-turnover-in-mouse-brain-with-desorption-electrospray-ionization-mass-spectrometry
#15
Richard H Carson, Charlotte R Lewis, Mercede N Erickson, Anna P Zagieboylo, Bradley C Naylor, Kelvin W Li, Paul B Farnsworth, John C Price
Compartmentalization of metabolism into specific regions of the cell, tissue, and organ is critical to life for all organisms. Mass spectrometric imaging techniques have been valuable in identifying and quantifying concentrations of metabolites in specific locations of cells and tissues, but a true understanding of metabolism requires measurement of metabolite flux on a spatially resolved basis. Here, we utilize desorption ESI-MS (DESI-MS) to measure lipid turnover in the brains of mice. We show that anatomically distinct regions of the brain have distinct lipid turnover rates...
September 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28692132/plasma-protein-electrophoresis-as-a-prognostic-indicator-in-aspergillus-species-infected-gentoo-penguins-pygoscelis-papua-papua
#16
Adam D Naylor, Simon J Girling, Donna Brown, Claire G Crompton, Romain Pizzi
BACKGROUND: Avian aspergillosis presents a significant threat to captive penguin populations. Currently, a lack of objective prognostic factors limits disease staging, objective reassessment throughout treatment, comparative evaluation of treatment regimes, and appropriate timing of euthanasia. OBJECTIVE: The study objective was to investigate absolute and relative plasma protein fractions by agarose gel electrophoresis (EPH) as predictors of survival in Gentoo penguins (Pygoscelis papua papua) under treatment for aspergillosis...
July 10, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28671670/multimerin-2-is-a-ligand-for-group-14-family-c-type-lectins-clec14a-cd93-and-cd248-spanning-the-endothelial-pericyte-interface
#17
K A Khan, A J Naylor, A Khan, P J Noy, M Mambretti, P Lodhia, J Athwal, A Korzystka, C D Buckley, B E Willcox, F Mohammed, R Bicknell
The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis. CD248 (alternatively known as endosialin or tumour endothelial marker-1) is also a member of this family and is expressed by tumour-associated fibroblasts and pericytes. Multimerin-2 (MMRN2) is a unique endothelial specific extracellular matrix protein that has been implicated in angiogenesis and tumour progression. We show that the group 14 C-type lectins CLEC14A, CD93 and CD248 directly bind to MMRN2 and only thrombomodulin of the family does not...
November 2, 2017: Oncogene
https://www.readbyqxmd.com/read/28642146/is-antimicrobial-stewardship-cost-effective-a-narrative-review-of-the-evidence
#18
REVIEW
N R Naylor, N Zhu, M Hulscher, A Holmes, R Ahmad, J V Robotham
AIMS: This narrative review aimed to collate recent evidence on the cost-effectiveness and cost-benefit of antimicrobial stewardship (AMS) programmes, to address the question 'is AMS cost-effective?', while providing resources and guidance for future research in this area. SOURCES: PubMed was searched for studies assessing the cost-effectiveness, cost-utility or cost-benefit of AMS interventions in humans, published from January 2000 to March 2017, with no setting inclusion/exclusion criteria specified...
November 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28631236/use-of-ctx-i-and-pinp-as-bone-turnover-markers-national-bone-health-alliance-recommendations-to-standardize-sample-handling-and-patient-preparation-to-reduce-pre-analytical-variability
#19
P Szulc, K Naylor, N R Hoyle, R Eastell, E T Leary
The National Bone Health Alliance (NBHA) recommends standardized sample handling and patient preparation for C-terminal telopeptide of type I collagen (CTX-I) and N-terminal propeptide of type I procollagen (PINP) measurements to reduce pre-analytical variability. Controllable and uncontrollable patient-related factors are reviewed to facilitate interpretation and minimize pre-analytical variability. INTRODUCTION: The IOF and the International Federation of Clinical Chemistry (IFCC) Bone Marker Standards Working Group have identified PINP and CTX-I in blood to be the reference markers of bone turnover for the fracture risk prediction and monitoring of osteoporosis treatment...
September 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28604837/dynamic-changes-in-diffusion-measures-improve-sensitivity-in-identifying-patients-with-mild-traumatic-brain-injury
#20
Alexander W Thomas, Richard Watts, Christopher G Filippi, Joshua P Nickerson, Trevor Andrews, Gregory Lieberman, Magdalena R Naylor, Margaret J Eppstein, Kalev Freeman
The goal of this study was to investigate patterns of axonal injury in the first week after mild traumatic brain injury (mTBI). We performed a prospective cohort study of 20 patients presenting to the emergency department with mTBI, using 3.0T diffusion tensor MRI immediately after injury and again at 1 week post-injury. Corresponding data were acquired from 16 controls over a similar time interval. Fractional anisotropy (FA) and other diffusion measures were calculated from 11 a priori selected axon tracts at each time-point, and the change across time in each region was quantified for each subject...
2017: PloS One
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