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A.R. Naylor

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https://www.readbyqxmd.com/read/29117179/a-mutation-in-the-viral-sensor-2-5-oligoadenylate-synthetase-2-causes-failure-of-lactation
#1
Samantha R Oakes, David Gallego-Ortega, Prudence M Stanford, Simon Junankar, Wendy Wing Yee Au, Zoya Kikhtyak, Anita von Korff, Claudio M Sergio, Andrew M K Law, Lesley E Castillo, Stephanie L Allerdice, Adelaide I J Young, Catherine Piggin, Belinda Whittle, Edward Bertram, Matthew J Naylor, Daniel L Roden, Jesse Donovan, Alexei Korennykh, Christopher C Goodnow, Moira K O'Bryan, Christopher J Ormandy
We identified a non-synonymous mutation in Oas2 (I405N), a sensor of viral double-stranded RNA, from an ENU-mutagenesis screen designed to discover new genes involved in mammary development. The mutation caused post-partum failure of lactation in healthy mice with otherwise normally developed mammary glands, characterized by greatly reduced milk protein synthesis coupled with epithelial cell death, inhibition of proliferation and a robust interferon response. Expression of mutant but not wild type Oas2 in cultured HC-11 or T47D mammary cells recapitulated the phenotypic and transcriptional effects observed in the mouse...
November 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29095386/torticollis-and-fever-in-a-young-boy-a-unique-presentation-of-cat-scratch-disease-with-vertebral-osteomyelitis-and-epidural-phlegmon
#2
Jason R Rafferty, Elizabeth Janopaul-Naylor, Jeffrey Riese
Cat-scratch disease-associated vertebral osteomyelitis and epidural involvement are rare and may manifest with nonspecific chronic symptoms in children, such as fever or torticollis. We present only the fourth case in the literature describing epidural involvement in an immunocompetent boy presenting with fever, torticollis, and indiscriminate left upper back tenderness. Bartonella henselae serologies are important to consider because such atypical complications often are responsive to conservative management with antibiotics...
October 31, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29073499/management-of-major-vascular-injury-during-pedicle-screw-instrumentation-of-thoracolumbar-spine
#3
Aleem K Mirza, Mohammed Ali Alvi, Ryan M Naylor, Panagiotis Kerezoudis, William E Krauss, Michelle J Clarke, Daniel L Shepherd, Ahmad Nassr, Randall R DeMartino, Mohamad Bydon
OBJECTIVES: Vascular injury is a rare complication of spinal instrumentation. Presentation can vary from immediate hemorrhage to pseudoaneurysm formation. In the literature, surgical approach to repair has varied based on anatomy, acuity of diagnosis, infection, and available technology. In this manuscript, we aim to describe our institutional experience with vascular injuries in thoraco-lumbar spine surgery. PATIENTS AND METHODS: We report our institutional experience of three cases of vascular injury secondary to pedicle screw misplacement and their management, as well as a review of the literature...
October 16, 2017: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29035678/the-relationships-between-impact-location-and-post-impact-ball-speed-bat-torsion-and-ball-direction-in-cricket-batting
#4
C Peploe, S A McErlain-Naylor, A R Harland, M A King
Three-dimensional kinematic data of bat and ball were recorded for 239 individual shots performed by twenty batsmen ranging from club to international standard. The impact location of the ball on the bat face was determined and assessed against the resultant instantaneous post-impact ball speed and measures of post-impact bat torsion and ball direction. Significant negative linear relationships were found between post-impact ball speed and the absolute distance of impact from the midline medio-laterally and sweetspot longitudinally...
October 16, 2017: Journal of Sports Sciences
https://www.readbyqxmd.com/read/29034571/association-between-subclinical-thyroid-dysfunction-and-change-in-bone-mineral-density-in-prospective-cohorts
#5
D Segna, D C Bauer, M Feller, C Schneider, H A Fink, C E Aubert, T-H Collet, B R da Costa, K Fischer, R P Peeters, A R Cappola, M R Blum, H A van Dorland, J Robbins, K Naylor, R Eastell, A G Uitterlinden, F Rivadeneira Ramirez, A Gogakos, J Gussekloo, G R Williams, A Schwartz, J A Cauley, D A Aujesky, H A Bischoff-Ferrari, N Rodondi
BACKGROUND: Subclinical hyperthyroidism (SHyper) has been associated with increased risk of hip and other fractures, but the linking mechanisms remain unclear. OBJECTIVE: To investigate the association between subclinical thyroid dysfunction and bone loss. METHODS: Individual participant data analysis was performed after a systematic literature search in MEDLINE/EMBASE (1946-2016). Two reviewers independently screened and selected prospective cohorts providing baseline thyroid status and serial bone mineral density (BMD) measurements...
October 16, 2017: Journal of Internal Medicine
https://www.readbyqxmd.com/read/28930627/fitness-body-composition-and-vascular-health-in-adolescent-and-young-adult-survivors-of-paediatric-brain-cancer-and-cranial-radiotherapy
#6
Treya M Long, Shoshana R Rath, Tessa D Maroni, Karen E Wallman, Helen C Atkinson, Nicholas G Gottardo, Catherine H Cole, Catherine S Choong, Louise H Naylor
Background Survivors of paediatric brain cancer and/or cranial radiotherapy (CRT) are at an increased risk of developing serious comorbidities. Established risk factors for chronic disease include central obesity, endothelial abnormalities and diminished fitness. Objectives Here we characterised anthropometry, body composition, bone mineral density (BMD), heart rate (HR), blood pressure (BP), endothelial function, muscular strength and endurance and aerobic fitness in adolescent and young adult (AYA) survivors...
September 20, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28888385/something-old-something-new-something-borrowed-and-something-blue
#7
EDITORIAL
A R Naylor, M Vega de Ceniga
No abstract text is available yet for this article.
October 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28851594/management-of-atherosclerotic-carotid-and-vertebral-artery-disease-2017-clinical-practice-guidelines-of-the-european-society-for-vascular-surgery-esvs
#8
Writing Group, A R Naylor, J-B Ricco, G J de Borst, S Debus, J de Haro, A Halliday, G Hamilton, J Kakisis, S Kakkos, S Lepidi, H S Markus, D J McCabe, J Roy, H Sillesen, J C van den Berg, F Vermassen, Esvs Guidelines Committee, P Kolh, N Chakfe, R J Hinchliffe, I Koncar, J S Lindholt, M Vega de Ceniga, F Verzini, Esvs Guideline Reviewers, J Archie, S Bellmunt, A Chaudhuri, M Koelemay, A-K Lindahl, F Padberg, M Venermo
No abstract text is available yet for this article.
August 26, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28802119/gambling-with-antibiotics-a-novel-approach-for-exploring-antibiotic-consumption-decision-making
#9
N R Naylor, I Uchegbu, A Chatterjee, J V Robotham
No abstract text is available yet for this article.
October 2017: Public Health
https://www.readbyqxmd.com/read/28743728/imaging-regiospecific-lipid-turnover-in-mouse-brain-with-desorption-electrospray-ionization-mass-spectrometry
#10
Richard H Carson, Charlotte R Lewis, Mercede N Erickson, Anna P Zagieboylo, Bradley C Naylor, Kelvin W Li, Paul B Farnsworth, John C Price
Compartmentalization of metabolism into specific regions of the cell, tissue, and organ is critical to life for all organisms. Mass spectrometric imaging techniques have been valuable in identifying and quantifying concentrations of metabolites in specific locations of cells and tissues, but a true understanding of metabolism requires measurement of metabolite flux on a spatially resolved basis. Here, we utilize desorption ESI-MS (DESI-MS) to measure lipid turnover in the brains of mice. We show that anatomically distinct regions of the brain have distinct lipid turnover rates...
September 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28692132/plasma-protein-electrophoresis-as-a-prognostic-indicator-in-aspergillus-species-infected-gentoo-penguins-pygoscelis-papua-papua
#11
Adam D Naylor, Simon J Girling, Donna Brown, Claire G Crompton, Romain Pizzi
BACKGROUND: Avian aspergillosis presents a significant threat to captive penguin populations. Currently, a lack of objective prognostic factors limits disease staging, objective reassessment throughout treatment, comparative evaluation of treatment regimes, and appropriate timing of euthanasia. OBJECTIVE: The study objective was to investigate absolute and relative plasma protein fractions by agarose gel electrophoresis (EPH) as predictors of survival in Gentoo penguins (Pygoscelis papua papua) under treatment for aspergillosis...
July 10, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28671670/multimerin-2-is-a-ligand-for-group-14-family-c-type-lectins-clec14a-cd93-and-cd248-spanning-the-endothelial-pericyte-interface
#12
K A Khan, A J Naylor, A Khan, P J Noy, M Mambretti, P Lodhia, J Athwal, A Korzystka, C D Buckley, B E Willcox, F Mohammed, R Bicknell
The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis. CD248 (alternatively known as endosialin or tumour endothelial marker-1) is also a member of this family and is expressed by tumour-associated fibroblasts and pericytes. Multimerin-2 (MMRN2) is a unique endothelial specific extracellular matrix protein that has been implicated in angiogenesis and tumour progression. We show that the group 14 C-type lectins CLEC14A, CD93 and CD248 directly bind to MMRN2 and only thrombomodulin of the family does not...
November 2, 2017: Oncogene
https://www.readbyqxmd.com/read/28642146/is-antimicrobial-stewardship-cost-effective-a-narrative-review-of-the-evidence
#13
REVIEW
N R Naylor, N Zhu, M Hulscher, A Holmes, R Ahmad, J V Robotham
AIMS: This narrative review aimed to collate recent evidence on the cost-effectiveness and cost-benefit of antimicrobial stewardship (AMS) programmes, to address the question 'is AMS cost-effective?', while providing resources and guidance for future research in this area. SOURCES: PubMed was searched for studies assessing the cost-effectiveness, cost-utility or cost-benefit of AMS interventions in humans, published from January 2000 to March 2017, with no setting inclusion/exclusion criteria specified...
November 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28631236/use-of-ctx-i-and-pinp-as-bone-turnover-markers-national-bone-health-alliance-recommendations-to-standardize-sample-handling-and-patient-preparation-to-reduce-pre-analytical-variability
#14
P Szulc, K Naylor, N R Hoyle, R Eastell, E T Leary
The National Bone Health Alliance (NBHA) recommends standardized sample handling and patient preparation for C-terminal telopeptide of type I collagen (CTX-I) and N-terminal propeptide of type I procollagen (PINP) measurements to reduce pre-analytical variability. Controllable and uncontrollable patient-related factors are reviewed to facilitate interpretation and minimize pre-analytical variability. INTRODUCTION: The IOF and the International Federation of Clinical Chemistry (IFCC) Bone Marker Standards Working Group have identified PINP and CTX-I in blood to be the reference markers of bone turnover for the fracture risk prediction and monitoring of osteoporosis treatment...
June 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28604837/dynamic-changes-in-diffusion-measures-improve-sensitivity-in-identifying-patients-with-mild-traumatic-brain-injury
#15
Alexander W Thomas, Richard Watts, Christopher G Filippi, Joshua P Nickerson, Trevor Andrews, Gregory Lieberman, Magdalena R Naylor, Margaret J Eppstein, Kalev Freeman
The goal of this study was to investigate patterns of axonal injury in the first week after mild traumatic brain injury (mTBI). We performed a prospective cohort study of 20 patients presenting to the emergency department with mTBI, using 3.0T diffusion tensor MRI immediately after injury and again at 1 week post-injury. Corresponding data were acquired from 16 controls over a similar time interval. Fractional anisotropy (FA) and other diffusion measures were calculated from 11 a priori selected axon tracts at each time-point, and the change across time in each region was quantified for each subject...
2017: PloS One
https://www.readbyqxmd.com/read/28570865/cyclic-peptide-natural-products-chart-the-frontier-of-oral-bioavailability-in-the-pursuit-of-undruggable-targets
#16
REVIEW
Matthew R Naylor, Andrew T Bockus, Maria-Jesus Blanco, R Scott Lokey
As interest in protein-protein interactions and other previously-undruggable targets increases, medicinal chemists are returning to natural products for design inspiration toward molecules that transcend the paradigm of small molecule drugs. These compounds, especially peptides, often have poor ADME properties and thus require a more nuanced understanding of structure-property relationships to achieve desirable oral bioavailability. Although there have been few clinical successes in this chemical space to date, recent work has identified opportunities to introduce favorable physicochemical properties to peptidic macrocycles that maintain activity and oral bioavailability...
June 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28567699/effects-of-nalfurafine-on-the-reinforcing-thermal-antinociceptive-and-respiratory-depressant-effects-of-oxycodone-modeling-an-abuse-deterrent-opioid-analgesic-in-rats
#17
E Andrew Townsend, Jennifer E Naylor, S Stevens Negus, Shelley R Edwards, Hina N Qureshi, Hunter W McLendon, Christopher R McCurdy, Coco N Kapanda, Jussara M do Carmo, Fernanda S da Silva, John E Hall, Kenneth J Sufka, Kevin B Freeman
RATIONALE: Strategies to reduce the misuse of mu opioid agonists are critically needed. Previous work has shown that kappa opioid agonists can diminish the abuse-related effects and augment the antinociceptive effects of mu agonists. However, use of traditional kappa agonists is limited by their dysphoric side effects. OBJECTIVES: The current study examined the effects of nalfurafine, a clinically available atypical kappa agonist, on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone in male rats...
May 31, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28555750/research-priorities-to-advance-the-health-and-health-care-of-older-adults-with-multiple-chronic-conditions
#18
Mayra Tisminetzky, Elizabeth A Bayliss, Jay S Magaziner, Heather G Allore, Kathryn Anzuoni, Cynthia M Boyd, Thomas M Gill, Alan S Go, Susan L Greenspan, Leah R Hanson, Mark C Hornbrook, Dalane W Kitzman, Eric B Larson, Mary D Naylor, Benjamin E Shirley, Ming Tai-Seale, Linda Teri, Mary E Tinetti, Heather E Whitson, Jerry H Gurwitz
OBJECTIVES: To prioritize research topics relevant to the care of the growing population of older adults with multiple chronic conditions (MCCs). DESIGN: Survey of experts in MCC practice, research, and policy. Topics were derived from white papers, funding announcements, or funded research projects relating to older adults with MCCs. SETTING: Survey conducted through the Health Care Systems Research Network (HCSRN) and Claude D. Pepper Older Americans Independence Centers (OAICs) Advancing Geriatrics Infrastructure and Network Growth Initiative, a joint endeavor of the HCSRN and OAICs...
July 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28363431/restenosis-after-carotid-interventions-and-its-relationship-with-recurrent-ipsilateral-stroke-a-systematic-review-and-meta-analysis
#19
REVIEW
R Kumar, A Batchelder, A Saratzis, A F AbuRahma, P Ringleb, B K Lal, J L Mas, M Steinbauer, A R Naylor
OBJECTIVE: Do asymptomatic restenoses > 70% after carotid endarterectomy (CEA) and carotid stenting (CAS) increase the risk of late ipsilateral stroke? METHODS: Systematic review identified 11 randomised controlled trials (RCTs) reporting rates of restenosis > 70% (and/or occlusion) in patients who had undergone CEA/CAS for the treatment of primary atherosclerotic disease, and nine RCTs reported late ipsilateral stroke rates. Proportional meta-analyses and odds ratios (OR) at end of follow-up were performed...
June 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28341185/c-mac-compared-with-direct-laryngoscopy-for-intubation-in-patients-with-cervical-spine-immobilization-a-manikin-trial
#20
COMPARATIVE STUDY
Jacek Smereka, Jerzy R Ladny, Amanda Naylor, Kurt Ruetzler, Lukasz Szarpak
INTRODUCTION: The aim of this study was to compare C-MAC videolaryngoscopy with direct laryngoscopy for intubation in simulated cervical spine immobilization conditions. METHODS: The study was designed as a prospective randomized crossover manikin trial. 70 paramedics with <5years of medical experience participated in the study. The paramedics attempted to intubate manikins in 3 airway scenarios: normal airway without cervical immobilization (Scenario A); manual inline cervical immobilization (Scenario B); cervical immobilization using cervical extraction collar (Scenario C)...
August 2017: American Journal of Emergency Medicine
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