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A.R. Naylor

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https://www.readbyqxmd.com/read/28930627/fitness-body-composition-and-vascular-health-in-adolescent-and-young-adult-survivors-of-paediatric-brain-cancer-and-cranial-radiotherapy
#1
Treya M Long, Shoshana R Rath, Tessa D Maroni, Karen E Wallman, Helen C Atkinson, Nicholas G Gottardo, Catherine H Cole, Catherine S Choong, Louise H Naylor
Background Survivors of paediatric brain cancer and/or cranial radiotherapy (CRT) are at an increased risk of developing serious comorbidities. Established risk factors for chronic disease include central obesity, endothelial abnormalities and diminished fitness. Objectives Here we characterised anthropometry, body composition, bone mineral density (BMD), heart rate (HR), blood pressure (BP), endothelial function, muscular strength and endurance and aerobic fitness in adolescent and young adult (AYA) survivors...
September 20, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/28888385/something-old-something-new-something-borrowed-and-something-blue
#2
EDITORIAL
A R Naylor, M Vega de Ceniga
No abstract text is available yet for this article.
October 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28851594/management-of-atherosclerotic-carotid-and-vertebral-artery-disease-2017-clinical-practice-guidelines-of-the-european-society-for-vascular-surgery-esvs
#3
Writing Group, A R Naylor, J-B Ricco, G J de Borst, S Debus, J de Haro, A Halliday, G Hamilton, J Kakisis, S Kakkos, S Lepidi, H S Markus, D J McCabe, J Roy, H Sillesen, J C van den Berg, F Vermassen, Esvs Guidelines Committee, P Kolh, N Chakfe, R J Hinchliffe, I Koncar, J S Lindholt, M Vega de Ceniga, F Verzini, Esvs Guideline Reviewers, J Archie, S Bellmunt, A Chaudhuri, M Koelemay, A-K Lindahl, F Padberg, M Venermo
No abstract text is available yet for this article.
August 25, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28802119/gambling-with-antibiotics-a-novel-approach-for-exploring-antibiotic-consumption-decision-making
#4
N R Naylor, I Uchegbu, A Chatterjee, J V Robotham
No abstract text is available yet for this article.
October 2017: Public Health
https://www.readbyqxmd.com/read/28743728/imaging-regiospecific-lipid-turnover-in-mouse-brain-with-desorption-electrospray-ionization-mass-spectrometry
#5
Richard H Carson, Charlotte R Lewis, Mercede N Erickson, Anna P Zagieboylo, Bradley C Naylor, Kelvin W Li, Paul B Farnsworth, John C Price
Compartmentalization of metabolism into specific regions of the cell, tissue, and organ is critical to life for all organisms. Mass spectrometric imaging techniques have been valuable in identifying and quantifying concentrations of metabolites in specific locations of cells and tissues, but a true understanding of metabolism requires measurement of metabolite flux on a spatially resolved basis. Here, we utilize desorption ESI-MS (DESI-MS) to measure lipid turnover in the brains of mice. We show that anatomically distinct regions of the brain have distinct lipid turnover rates...
September 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28692132/plasma-protein-electrophoresis-as-a-prognostic-indicator-in-aspergillus-species-infected-gentoo-penguins-pygoscelis-papua-papua
#6
Adam D Naylor, Simon J Girling, Donna Brown, Claire G Crompton, Romain Pizzi
BACKGROUND: Avian aspergillosis presents a significant threat to captive penguin populations. Currently, a lack of objective prognostic factors limits disease staging, objective reassessment throughout treatment, comparative evaluation of treatment regimes, and appropriate timing of euthanasia. OBJECTIVE: The study objective was to investigate absolute and relative plasma protein fractions by agarose gel electrophoresis (EPH) as predictors of survival in Gentoo penguins (Pygoscelis papua papua) under treatment for aspergillosis...
July 10, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28671670/multimerin-2-is-a-ligand-for-group-14-family-c-type-lectins-clec14a-cd93-and-cd248-spanning-the-endothelial-pericyte-interface
#7
K A Khan, A J Naylor, A Khan, P J Noy, M Mambretti, P Lodhia, J Athwal, A Korzystka, C D Buckley, B E Willcox, F Mohammed, R Bicknell
The C-type lectin domain containing group 14 family members CLEC14A and CD93 are proteins expressed by endothelium and are implicated in tumour angiogenesis. CD248 (alternatively known as endosialin or tumour endothelial marker-1) is also a member of this family and is expressed by tumour-associated fibroblasts and pericytes. Multimerin-2 (MMRN2) is a unique endothelial specific extracellular matrix protein that has been implicated in angiogenesis and tumour progression. We show that the group 14 C-type lectins CLEC14A, CD93 and CD248 directly bind to MMRN2 and only thrombomodulin of the family does not...
July 3, 2017: Oncogene
https://www.readbyqxmd.com/read/28642146/is-antimicrobial-stewardship-cost-effective-a-narrative-review-of-the-evidence
#8
REVIEW
N R Naylor, N Zhu, M Hulscher, A Holmes, R Ahmad, J V Robotham
AIMS: This narrative review aimed to collate recent evidence on the cost-effectiveness and cost-benefit of antimicrobial stewardship (AMS) programmes, to address the question 'is AMS cost-effective?', while providing resources and guidance for future research in this area. SOURCES: PubMed was searched for studies assessing the cost-effectiveness, cost-utility or cost-benefit of AMS interventions in humans, published from January 2000 to March 2017, with no setting inclusion/exclusion criteria specified...
June 20, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28631236/use-of-ctx-i-and-pinp-as-bone-turnover-markers-national-bone-health-alliance-recommendations-to-standardize-sample-handling-and-patient-preparation-to-reduce-pre-analytical-variability
#9
P Szulc, K Naylor, N R Hoyle, R Eastell, E T Leary
The National Bone Health Alliance (NBHA) recommends standardized sample handling and patient preparation for C-terminal telopeptide of type I collagen (CTX-I) and N-terminal propeptide of type I procollagen (PINP) measurements to reduce pre-analytical variability. Controllable and uncontrollable patient-related factors are reviewed to facilitate interpretation and minimize pre-analytical variability. INTRODUCTION: The IOF and the International Federation of Clinical Chemistry (IFCC) Bone Marker Standards Working Group have identified PINP and CTX-I in blood to be the reference markers of bone turnover for the fracture risk prediction and monitoring of osteoporosis treatment...
June 19, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28604837/dynamic-changes-in-diffusion-measures-improve-sensitivity-in-identifying-patients-with-mild-traumatic-brain-injury
#10
Alexander W Thomas, Richard Watts, Christopher G Filippi, Joshua P Nickerson, Trevor Andrews, Gregory Lieberman, Magdalena R Naylor, Margaret J Eppstein, Kalev Freeman
The goal of this study was to investigate patterns of axonal injury in the first week after mild traumatic brain injury (mTBI). We performed a prospective cohort study of 20 patients presenting to the emergency department with mTBI, using 3.0T diffusion tensor MRI immediately after injury and again at 1 week post-injury. Corresponding data were acquired from 16 controls over a similar time interval. Fractional anisotropy (FA) and other diffusion measures were calculated from 11 a priori selected axon tracts at each time-point, and the change across time in each region was quantified for each subject...
2017: PloS One
https://www.readbyqxmd.com/read/28570865/cyclic-peptide-natural-products-chart-the-frontier-of-oral-bioavailability-in-the-pursuit-of-undruggable-targets
#11
REVIEW
Matthew R Naylor, Andrew T Bockus, Maria-Jesus Blanco, R Scott Lokey
As interest in protein-protein interactions and other previously-undruggable targets increases, medicinal chemists are returning to natural products for design inspiration toward molecules that transcend the paradigm of small molecule drugs. These compounds, especially peptides, often have poor ADME properties and thus require a more nuanced understanding of structure-property relationships to achieve desirable oral bioavailability. Although there have been few clinical successes in this chemical space to date, recent work has identified opportunities to introduce favorable physicochemical properties to peptidic macrocycles that maintain activity and oral bioavailability...
June 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28567699/effects-of-nalfurafine-on-the-reinforcing-thermal-antinociceptive-and-respiratory-depressant-effects-of-oxycodone-modeling-an-abuse-deterrent-opioid-analgesic-in-rats
#12
E Andrew Townsend, Jennifer E Naylor, S Stevens Negus, Shelley R Edwards, Hina N Qureshi, Hunter W McLendon, Christopher R McCurdy, Coco N Kapanda, Jussara M do Carmo, Fernanda S da Silva, John E Hall, Kenneth J Sufka, Kevin B Freeman
RATIONALE: Strategies to reduce the misuse of mu opioid agonists are critically needed. Previous work has shown that kappa opioid agonists can diminish the abuse-related effects and augment the antinociceptive effects of mu agonists. However, use of traditional kappa agonists is limited by their dysphoric side effects. OBJECTIVES: The current study examined the effects of nalfurafine, a clinically available atypical kappa agonist, on the reinforcing, thermal antinociceptive, and respiratory-depressant effects of oxycodone in male rats...
May 31, 2017: Psychopharmacology
https://www.readbyqxmd.com/read/28555750/research-priorities-to-advance-the-health-and-health-care-of-older-adults-with-multiple-chronic-conditions
#13
Mayra Tisminetzky, Elizabeth A Bayliss, Jay S Magaziner, Heather G Allore, Kathryn Anzuoni, Cynthia M Boyd, Thomas M Gill, Alan S Go, Susan L Greenspan, Leah R Hanson, Mark C Hornbrook, Dalane W Kitzman, Eric B Larson, Mary D Naylor, Benjamin E Shirley, Ming Tai-Seale, Linda Teri, Mary E Tinetti, Heather E Whitson, Jerry H Gurwitz
OBJECTIVES: To prioritize research topics relevant to the care of the growing population of older adults with multiple chronic conditions (MCCs). DESIGN: Survey of experts in MCC practice, research, and policy. Topics were derived from white papers, funding announcements, or funded research projects relating to older adults with MCCs. SETTING: Survey conducted through the Health Care Systems Research Network (HCSRN) and Claude D. Pepper Older Americans Independence Centers (OAICs) Advancing Geriatrics Infrastructure and Network Growth Initiative, a joint endeavor of the HCSRN and OAICs...
July 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28363431/restenosis-after-carotid-interventions-and-its-relationship-with-recurrent-ipsilateral-stroke-a-systematic-review-and-meta-analysis
#14
REVIEW
R Kumar, A Batchelder, A Saratzis, A F AbuRahma, P Ringleb, B K Lal, J L Mas, M Steinbauer, A R Naylor
OBJECTIVE: Do asymptomatic restenoses > 70% after carotid endarterectomy (CEA) and carotid stenting (CAS) increase the risk of late ipsilateral stroke? METHODS: Systematic review identified 11 randomised controlled trials (RCTs) reporting rates of restenosis > 70% (and/or occlusion) in patients who had undergone CEA/CAS for the treatment of primary atherosclerotic disease, and nine RCTs reported late ipsilateral stroke rates. Proportional meta-analyses and odds ratios (OR) at end of follow-up were performed...
June 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28341185/c-mac-compared-with-direct-laryngoscopy-for-intubation-in-patients-with-cervical-spine-immobilization-a-manikin-trial
#15
Jacek Smereka, Jerzy R Ladny, Amanda Naylor, Kurt Ruetzler, Lukasz Szarpak
INTRODUCTION: The aim of this study was to compare C-MAC videolaryngoscopy with direct laryngoscopy for intubation in simulated cervical spine immobilization conditions. METHODS: The study was designed as a prospective randomized crossover manikin trial. 70 paramedics with <5years of medical experience participated in the study. The paramedics attempted to intubate manikins in 3 airway scenarios: normal airway without cervical immobilization (Scenario A); manual inline cervical immobilization (Scenario B); cervical immobilization using cervical extraction collar (Scenario C)...
August 2017: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28268070/post-carotid-endarterectomy-hypertension-part-1-association-with-pre-operative-clinical-imaging-and-physiological-parameters
#16
J E Newman, M J Bown, R D Sayers, J P Thompson, T G Robinson, B Williams, R Panerai, P Lacy, A R Naylor
OBJECTIVE/BACKGROUND: Post-endarterectomy hypertension (PEH) is a well recognised, but poorly understood, phenomenon after carotid endarterectomy (CEA) that is associated with post-operative intracranial haemorrhage, hyperperfusion syndrome, and cardiac complications. The aim of the current study was to identify pre-operative clinical, imaging, and physiological parameters associated with PEH. METHODS: In total, 106 CEA patients undergoing CEA under general anaesthesia underwent pre-operative evaluation of 24 hour ambulatory arterial blood pressure (BP), baroreceptor sensitivity, cerebral autoregulation, and transcranial Doppler measurement of cerebral blood flow velocity (CBFv) and pulsatility index...
March 3, 2017: European Journal of Vascular and Endovascular Surgery
https://www.readbyqxmd.com/read/28249899/kr%C3%A3-ppel-like-transcription-factor-klf10-suppresses-tgf%C3%AE-induced-epithelial-to-mesenchymal-transition-via-a-negative-feedback-mechanism
#17
Vivek Kumar Mishra, Malayannan Subramaniam, Vijayalakshmi Kari, Kevin S Pitel, Simon J Baumgart, Ryan M Naylor, Sankari Nagarajan, Florian Wegwitz, Volker Ellenrieder, John R Hawse, Steven A Johnsen
TGFβ-SMAD signaling exerts a contextual effect that suppresses malignant growth early in epithelial tumorigenesis but promotes metastasis at later stages. Longstanding challenges in resolving this functional dichotomy may uncover new strategies to treat advanced carcinomas. The Krüppel-like transcription factor, KLF10, is a pivotal effector of TGFβ/SMAD signaling that mediates antiproliferative effects of TGFβ. In this study, we show how KLF10 opposes the prometastatic effects of TGFβ by limiting its ability to induce epithelial-to-mesenchymal transition (EMT)...
May 1, 2017: Cancer Research
https://www.readbyqxmd.com/read/28215073/identification-of-highly-specific-diversity-oriented-synthesis-derived-inhibitors-of-clostridium-difficile
#18
Jeremy R Duvall, Leanne Bedard, Adel M Naylor-Olsen, Abigail L Manson, Joshua A Bittker, Wenye Sun, Mark E Fitzgerald, Zhenmin He, Maurice D Lee, Jean-Charles Marie, Giovanni Muncipinto, Diane Rush, Deming Xu, Huisheng Xu, Mingliang Zhang, Ashlee M Earl, Michelle A Palmer, Michael A Foley, Joseph P Vacca, Christina A Scherer
In 2013, the Centers for Disease Control highlighted Clostridium difficile as an urgent threat for antibiotic-resistant infections, in part due to the emergence of highly virulent fluoroquinolone-resistant strains. Limited therapeutic options currently exist, many of which result in disease relapse. We sought to identify molecules specifically targeting C. difficile in high-throughput screens of our diversity-oriented synthesis compound collection. We identified two scaffolds with apparently novel mechanisms of action that selectively target C...
May 12, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/28129565/cannabis-use-disorder-and-suicide-attempts-in-iraq-afghanistan-era-veterans
#19
MULTICENTER STUDY
Nathan A Kimbrel, Amie R Newins, Eric A Dedert, Elizabeth E Van Voorhees, Eric B Elbogen, Jennifer C Naylor, H Ryan Wagner, Mira Brancu, Jean C Beckham, Patrick S Calhoun
The objective of the present research was to examine the association between lifetime cannabis use disorder (CUD), current suicidal ideation, and lifetime history of suicide attempts in a large and diverse sample of Iraq/Afghanistan-era veterans (N = 3233) using a battery of well-validated instruments. As expected, CUD was associated with both current suicidal ideation (OR = 1.683, p = 0.008) and lifetime suicide attempts (OR = 2.306, p < 0.0001), even after accounting for the effects of sex, posttraumatic stress disorder, depression, alcohol use disorder, non-cannabis drug use disorder, history of childhood sexual abuse, and combat exposure...
June 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28114993/an-equivalence-study-are-patient-completed-and-telephone-interview-equivalent-modes-of-administration-for-the-euroqol-survey
#20
R Chatterji, J M Naylor, I A Harris, E Armstrong, E Davidson, R Ekmejian, J Descallar
BACKGROUND: To determine if the EuroQol Health Related Quality of Life survey produces equivalent results when administered by phone interview or patient-completed forms. METHODS: People awaiting hip or knee arthroplasty at a major metropolitan hospital participated. They were randomly assigned to receive the EuroQol Health Related Quality of Life survey via telephone, followed by a patient completed form 1 week later, or vice versa. Equivalence was determined using two one-sided tests (TOST) based on minimal clinically-important differences for the visual analogue scale (VAS) and the summary Utility Index...
January 23, 2017: Health and Quality of Life Outcomes
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