Itamar Jalon, Assaf Berger, Ben Shofty, Noam Goldway, Moran Artzi, Guy Gurevitch, Uri Hochberg, Rotem Tellem, Talma Hendler, Tal Gonen, Ido Strauss
Human pain is a salient stimulus composed of two main components: a sensory\somatic component, carrying peripheral nociceptive sensation via the spino-thalamic tract and brainstem nuclei to the thalamus and then to sensory cortical regions, and an affective (suffering) component, where information from central thalamic nuclei is carried to the anterior insula, dorsal anterior cingulate cortex and other regions. While the sensory component processes information about stimulus location and intensity, the affective component processes information regarding pain-related expectations, motivation to reduce pain, and pain unpleasantness...
October 31, 2022: Brain