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https://www.readbyqxmd.com/read/28334641/humanized-mouse-model-for-assessing-the-human-immune-response-to-xenogeneic-and-allogeneic-decellularized-biomaterials
#1
Raymond M Wang, Todd D Johnson, Jingjin He, Zhili Rong, Michelle Wong, Vishal Nigam, Atta Behfar, Yang Xu, Karen L Christman
Current assessment of biomaterial biocompatibility is typically implemented in wild type rodent models. Unfortunately, different characteristics of the immune systems in rodents versus humans limit the capability of these models to mimic the human immune response to naturally derived biomaterials. Here we investigated the utility of humanized mice as an improved model for testing naturally derived biomaterials. Two injectable hydrogels derived from decellularized porcine or human cadaveric myocardium were compared...
March 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28334629/diabetes-knowledge-and-perceptions-among-nursing-students-and-curriculum-differences-in-japan-and-australia-a-cross-sectional-study
#2
Lucie M Ramjan, Hiroko Watanabe, Yenna Salamonson
OBJECTIVES: To investigate the associations between knowledge and perceptions of diabetes mellitus (DM) among nursing students from Japan and Australia; and to compare curriculum differences. RESEARCH DESIGN AND METHODS: Cross-sectional study. Convenience sample of students from Japan (N=78) and Australia (N=85) in their final year were surveyed. Students reported demographic details, and perceptions towards caring for patients with DM. The 23-item Michigan Diabetes Knowledge Test (MDKT) was used to assess general knowledge, and seven additional questions were used to assess DM-related clinical knowledge (CDKT)...
March 16, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/28333989/street-trees-reduce-the-negative-effects-of-urbanization-on-birds
#3
João Carlos de Castro Pena, Felipe Martello, Milton Cezar Ribeiro, Richard A Armitage, Robert J Young, Marcos Rodrigues
The effects of streets on biodiversity is an important aspect of urban ecology, but it has been neglected worldwide. Several vegetation attributes (e.g. street tree density and diversity) have important effects on biodiversity and ecological processes. In this study, we evaluated the influences of urban vegetation-represented by characteristics of street trees (canopy size, proportion of native tree species and tree species richness)-and characteristics of the landscape (distance to parks and vegetation quantity), and human impacts (human population size and exposure to noise) on taxonomic data and functional diversity indices of the bird community inhabiting streets...
2017: PloS One
https://www.readbyqxmd.com/read/28333789/nursing-informatics-competency-assessment-for-the-nurse-leader-the-delphi-study
#4
Sarah Collins, Po-Yin Yen, Andrew Phillips, Mary K Kennedy
OBJECTIVE: The aim of this study was to identify nursing informatics competencies perceived as relevant and required by nurse leaders. BACKGROUND: To participate as a full partner in healthcare leadership among rapidly advancing health information technologies (HITs), nurse leaders must attain knowledge of informatics competencies related to their clinical leadership roles and responsibilities. Despite this increased need to engage in HIT-related decision making, a gap remains in validated informatics competencies specific to the needs of nurse leaders...
April 2017: Journal of Nursing Administration
https://www.readbyqxmd.com/read/28333609/fundamental-use-of-surgical-energy-fuse-an-essential-educational-program-for-operating-room-safety
#5
Stephanie B Jones, Malcolm G Munro, Liane S Feldman, Thomas N Robinson, L Michael Brunt, Steven D Schwaitzberg, Daniel B Jones, Pascal R Fuchshuber
Operating room (OR) safety has become a major concern in patient safety since the 1990s. Improvement of team communication and behavior is a popular target for safety programming at the institutional level. Despite these efforts, essential safety gaps remain in the OR and procedure rooms. A prime example is the use of energy-based devices in ORs and procedural areas. The lack of fundamental understanding of energy device function, design, and application contributes to avoidable injury and harm at a rate of approximately 1 to 2 per 1000 patients in the US...
2017: Permanente Journal
https://www.readbyqxmd.com/read/28333321/preconception-and-early-pregnancy-maternal-haemodynamic-changes-in-healthy-women-in-relation-to-pregnancy-viability
#6
F L Foo, A Collins, C M McEniery, P R Bennett, I B Wilkinson, C C Lees
STUDY QUESTION: Are there differences in preconception cardiovascular function between women who have a viable pregnancy and those who have a first trimester miscarriage? SUMMARY ANSWER: Preconception cardiovascular function of central haemodynamics and arterial function are similar between women who have a viable pregnancy and those who have a first trimester miscarriage. WHAT IS KNOWN ALREADY: Miscarriages have been associated with increased long-term cardiovascular disease risk, and arterial and cardiovascular dysfunction has been hypothesised as the common link...
March 16, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28333275/anti-m%C3%A3-llerian-hormone-inhibits-activation-and-growth-of-bovine-ovarian-follicles-in-vitro-and-is-localized-to-growing-follicles
#7
M Y Yang, R A Cushman, J E Fortune
STUDY QUESTION: Does anti-Müllerian hormone (AMH) inhibit activation (initiation of growth) of primordial follicles and attenuate the growth of primary follicles in cattle, an excellent animal model for human ovarian follicular development? SUMMARY ANSWER: AMH inhibited activation of bovine primordial follicles and attenuated the growth of activated follicles in vitro. WHAT IS KNOWN ALREADY: In mice null mutant for AMH, the pool of primordial follicles is depleted prematurely and AMH inhibits follicle activation in vitro...
March 17, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28333019/a-comparison-between-low-dose-rate-brachytherapy-with-or-without-androgen-deprivation-external-beam-radiation-therapy-with-or-without-androgen-deprivation-and-radical-prostatectomy-with-or-without-adjuvant-or-salvage-radiation-therapy-for-high-risk-prostate
#8
Jay P Ciezki, Michael Weller, Chandana A Reddy, Jeffrey Kittel, Harguneet Singh, Rahul Tendulkar, Kevin L Stephans, James Ulchaker, Kenneth Angermeier, Andrew Stephenson, Steven Campbell, Georges-Pascal Haber, Eric A Klein
PURPOSE: We compare the efficacy and toxicity among the 3 major modalities available used to treat high-risk prostate cancer (HRCaP). METHODS AND MATERIALS: From 1996 to 2012, 2557 HRCaP patients were treated: 734 received external beam radiation therapy (EBRT) with or without androgen deprivation therapy (ADT), 515 received low-dose-rate prostate brachytherapy (LDR) with or without ADT, and 1308 received radical prostatectomy (RP) with or without EBRT. Biochemical relapse-free survival (bRFS), clinical relapse-free survival (cRFS), and prostate cancer-specific mortality (PCSM) were assessed...
April 1, 2017: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/28332942/a-statewide-screening-brief-intervention-and-referral-to-treatment-sbirt-curriculum-for-medical-residents-differential-implementation-strategies-in-heterogeneous-medical-residency-programs
#9
Janice L Pringle, Shannon M Kearney, Sherry Rickard-Aasen, Melinda M Campopiano, Adam J Gordon
BACKGROUND: Many screening, brief intervention, and referral to treatment (SBIRT) training curricula have been implemented within graduate medical residency training programs, with varying degrees of success. The authors examined the implementation of a uniform, but adaptable, statewide SBIRT curriculum in 7 diverse residency training programs and whether it could improve resident knowledge, skills, and attitudes regarding SBIRT and unhealthy alcohol and other drug (AOD) use. METHODS: The authors assessed the implementation of the Pennsylvania SBIRT Medical and Residency Training (SMaRT) curriculum at 7 residency sites training a variety of disciplines...
February 8, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28332419/defining-a-set-of-common-interprofessional-learning-competencies-for-health-profession-students
#10
Maree O'Keefe, Amanda Henderson, Rebecca Chick
INTRODUCTION: Increasingly recognized as a core component of contemporary health profession education, interprofessional learning outcomes remain difficult to define and assess across disciplines. The aim of this study was to identify a single set of interprofessional learning competency statements with relevance to all health professions. METHODS AND RESULTS: Six national and international interprofessional competency frameworks were reviewed and combined to give a total of 165 competency statements...
March 23, 2017: Medical Teacher
https://www.readbyqxmd.com/read/28331565/evaluation-of-prognostic-factors-effect-on-survival-time-in-patients-with-colorectal-cancer-based-on-weibull-competing-risks-model
#11
Soraya Moamer, Ahmadreza Baghestani, Mohamad Amin Pourhoseingholi, Nastaran Hajizadeh, Farzaneh Ahmadi, Mohsen Norouzinia
AIM: The aim of this study was to assess the association between survival of patients with colorectal cancer and prognostic factors in a competing risk parametric model using Weibull distribution. BACKGROUND: The prognosis of colorectal cancer is relatively good in terms of survival time. In many prognostic studies, patients may be exposed to several types of competing events. These different causes of death are called competing risks. METHODS: Data was recorded from 372 patients with colorectal cancer who registered in the Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences (Tehran, Iran) from 2004 to 2015 in a retrospective study...
2017: Gastroenterology and Hepatology From Bed to Bench
https://www.readbyqxmd.com/read/28330607/association-between-anti-thymocyte-globulin-exposure-and-survival-outcomes-in-adult-unrelated-haemopoietic-cell-transplantation-a-multicentre-retrospective-pharmacodynamic-cohort-analysis
#12
Rick Admiraal, Stefan Nierkens, Moniek A de Witte, Eefke J Petersen, Ger-Jan Fleurke, Luka Verrest, Svetlana V Belitser, Robbert G M Bredius, Reinier A P Raymakers, Catherijne A J Knibbe, Monique C Minnema, Charlotte van Kesteren, Jurgen Kuball, Jaap J Boelens
BACKGROUND: Anti-thymocyte globulin (ATG) is used to prevent graft-versus-host disease (GvHD) after allogeneic haemopoietic cell transplantation (HCT). However, ATG can also cause delayed immune reconstitution of T cells, negatively affecting survival. We studied the relation between exposure to ATG and clinical outcomes in adult patients with acute leukaemia and myelodysplastic syndrome. METHODS: We did a retrospective, pharmacokinetic-pharmacodynamic analysis of data from patients with acute lymphoid leukaemia, acute myeloid leukaemia, or myelodysplastic syndrome receiving their first T-cell repleted allogeneic peripheral blood stem cell HCT with ATG (thymoglobulin) as part of non-myeloablative conditioning from March 1, 2004, to June 1, 2015...
March 16, 2017: Lancet Haematology
https://www.readbyqxmd.com/read/28330589/ethnicity-and-excess-mortality-in-severe-mental-illness-a-cohort-study
#13
Jayati Das-Munshi, Chin-Kuo Chang, Rina Dutta, Craig Morgan, James Nazroo, Robert Stewart, Martin J Prince
BACKGROUND: Excess mortality in severe mental illness (defined here as schizophrenia, schizoaffective disorders, and bipolar affective disorders) is well described, but little is known about this inequality in ethnic minorities. We aimed to estimate excess mortality for people with severe mental illness for five ethnic groups (white British, black Caribbean, black African, south Asian, and Irish) and to assess the association of ethnicity with mortality risk. METHODS: We conducted a longitudinal cohort study of individuals with a valid diagnosis of severe mental illness between Jan 1, 2007, and Dec 31, 2014, from the case registry of the South London and Maudsley Trust (London, UK)...
March 16, 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/28330486/relationships-between-structure-process-and-outcome-to-assess-quality-of-integrated-chronic-disease-management-in-a-rural-south-african-setting-applying-a-structural-equation-model
#14
Soter Ameh, Francesc Xavier Gómez-Olivé, Kathleen Kahn, Stephen M Tollman, Kerstin Klipstein-Grobusch
BACKGROUND: South Africa faces a complex dual burden of chronic communicable and non-communicable diseases (NCDs). In response, the Integrated Chronic Disease Management (ICDM) model was initiated in primary health care (PHC) facilities in 2011 to leverage the HIV/ART programme to scale-up services for NCDs, achieve optimal patient health outcomes and improve the quality of medical care. However, little is known about the quality of care in the ICDM model. The objectives of this study were to: i) assess patients' and operational managers' satisfaction with the dimensions of ICDM services; and ii) evaluate the quality of care in the ICDM model using Avedis Donabedian's theory of relationships between structure (resources), process (clinical activities) and outcome (desired result of healthcare) constructs as a measure of quality of care...
March 23, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28329826/supportive-supervision-and-staff-intent-to-turn-over-in-long-term-care-homes
#15
Jennifer Bethell, Charlene H Chu, Walter P Wodchis, Kevin Walker, Steven C Stewart, Katherine S McGilton
Background and Objectives: To examine the association between supervisory support and intent to turn over among personal support workers (PSWs) employed in long-term care (LTC) homes in Ontario, Canada, by assessing whether the association is mediated by job satisfaction and the potential confounding effect of happiness. Research Design and Methods: Cross-sectional survey data of 5,645 PSWs working within 398 LTC homes in Ontario, Canada, were obtained and analysed through a series of multilevel regression models...
March 14, 2017: Gerontologist
https://www.readbyqxmd.com/read/28329795/construct-validation-of-wenger-s-support-network-typology
#16
Agnes Szabo, Christine Stephens, Joanne Allen, Fiona Alpass
Objectives: The study aimed to validate Wenger's empirically derived support network typology of responses to the Practitioner Assessment of Network Type (PANT) in an older New Zealander population. The configuration of network types was tested across ethnic groups and in the total sample. Method: Data (N = 872, Mage = 67 years, SDage = 1.56 years) from the 2006 wave of the New Zealand Health, Work and Retirement study were analyzed using latent profile analysis...
October 7, 2016: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28329659/predicting-the-risk-of-metachronous-basal-cell-carcinomas
#17
Hilde Smedinga, Joris A C Verkouteren, Ewout W Steyerberg, Albert Hofman, Tamar Nijsten, Y Vergouwe
A third of basal cell carcinoma (BCC) patients will develop metachronous BCCs, but information is limited on the frequency, timing and predictors of these subsequent BCCs. We aimed to develop a prediction model to assess the absolute risk of metachronous BCCs.We observed 14,628 participants of northwestern European ancestry from a prospective population- based cohort study (Rotterdam Study). BCCs were identified using a linkage with the Dutch Pathology Registry (PALGA). Predictors for subsequent BCCs included 14 patient, lifestyle, and tumor-specific characteristics...
September 15, 2016: Dermatology Online Journal
https://www.readbyqxmd.com/read/28329451/preliminary-experience-with-the-use-of-an-extracellular-matrix-to-augment-the-native-pulmonary-valve-during-repair-of-tetralogy-of-fallot
#18
Anil Dharmapuram, Nagarajan Ramadoss, Sudeep Verma, Vejendla Gouthami, Ivatury Rao
BACKGROUND: During repair of tetralogy of Fallot (TOF), when a transannular patch is needed in case of a small annulus and dysplastic pulmonary valve, we chose to reconstruct the right ventricular outflow tract by augmenting the divided anterior leaflet with an extracellular matrix (ECM) patch to produce a competent valve. In this study, we present our preliminary experience and early outcomes. METHODS: From March 2013 to December 2015, of the 206 patients who underwent primary repair of TOF, 52 required a transannular incision...
March 2017: World Journal for Pediatric & Congenital Heart Surgery
https://www.readbyqxmd.com/read/28329417/nursing-judgement-and-decision-making-using-the-sedation-withdrawal-score-sws-in-children
#19
Jennie Craske, Bernie Carter, Ian H Jarman, Lyvonne N Tume
AIMS: The aim of the study was to evaluate registered children's nurses' approaches to the assessment and management of withdrawal syndrome in children. BACKGROUND: Assessment of withdrawal syndrome is undertaken following critical illness when the child's condition may be unstable with competing differential diagnoses. Assessment tools aim to standardise and improve recognition of withdrawal syndrome. Making the right decisions in complex clinical situations requires a degree of mental effort and it is not known how nurses make decisions when undertaking withdrawal assessments...
March 22, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28328169/student-nurses-competence-in-sexual-health-care-a-literature-review
#20
REVIEW
Emma Pascale Blakey, Helen Aveyard
AIM: The aim of this literature review is to explore the way in which sexual health care is perceived and experienced by students in clinical practice. BACKGROUND: Student nurses understand the need to learn about sexual health but report a variety of learning needs and experience challenges acquiring skills to deliver such care in part due to varied clinical experience. Furthermore, there is a paucity of data exploring clinical competence of sexual health care among student nurses...
March 22, 2017: Journal of Clinical Nursing
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