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https://www.readbyqxmd.com/read/28631131/endoscopic-treatment-of-adult-idiopathic-obstruction-of-the-foramen-of-monro
#1
Waleed A Azab, Tarek M Alsheikh, Tamer M Elmansoury, Ehab A Abdelnabi
BACKGROUND: Adult idiopathic membranous obstruction of the foramen of Monro is an extremely rare condition that can be effectively treated with endoscopic foraminoplasty. A unilateral or bilateral foraminoplasty is performed if one or both of the foramina of Monro are obstructed, respectively. Endoscopic septum pellucidotomy is usually used in combination with the foraminoplasty. METHODS: The operative chart and video of one of our patients undergoing endoscopic treatment for adult idiopathic membranous obstruction of the foramen of Monro were retrieved from our database and reviewed...
June 19, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28629433/smoking-and-timing-of-cessation-on-postoperative-pulmonary-complications-after-curative-intent-lung-cancer-surgery
#2
Sebastian T Lugg, Theofano Tikka, Paula J Agostini, Amy Kerr, Kerry Adams, Maninder S Kalkat, Richard S Steyn, Pala B Rajesh, Ehab Bishay, David R Thickett, Babu Naidu
BACKGROUND: Smoking is a risk factor for postoperative pulmonary complications (PPC) following non-small cell lung cancer (NSCLC) surgery. The optimal timing for preoperative smoking cessation has not been identified. Our study aimed to observe the impact of preoperative smoking cessation on PPC incidence and other postoperative outcomes including long-term survival. METHODS: A prospective study included consecutive patients following resection for NSCLC in a regional thoracic centre over a 4-year period (2010-2014)...
June 19, 2017: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/28623625/switching-between-reference-biologics-and-biosimilars-for-the-treatment-of-rheumatology-gastroenterology-and-dermatology-inflammatory-conditions-considerations-for-the-clinician
#3
REVIEW
Robert Moots, Valderilio Azevedo, Javier L Coindreau, Thomas Dörner, Ehab Mahgoub, Eduardo Mysler, Morton Scheinberg, Lisa Marshall
PURPOSE OF REVIEW: Biosimilars of the reference biologic therapeutics infliximab, etanercept, adalimumab, and rituximab are entering the market. Clinical and real-world data on the effects of reference → biosimilar switching are limited. This review was carried out to assess the current body of switching data. RECENT FINDINGS: Fifty-three switching studies were identified. Infliximab publications covered CT-P13 (25 studies), SB2 (1), infliximab NK (1), and unspecified infliximab biosimilars (2)...
June 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28612339/osteocyte-mechanobiology
#4
REVIEW
Yuhei Uda, Ehab Azab, Ningyuan Sun, Chao Shi, Paola Divieti Pajevic
PURPOSE OF REVIEW: Over the past decades, osteocytes have emerged as mechano-sensors of bone and master regulators of bone homeostasis. This article summarizes latest research and progress made in understanding osteocyte mechanobiology and critically reviews tools currently available to study these cells. RECENT FINDINGS: Whereas increased mechanical forces promote bone formation, decrease loading is always associated with bone loss and skeletal fragility. Recent studies identified cilia, integrins, calcium channels, and G-protein coupled receptors as important sensors of mechanical forces and Ca(2+) and cAMP signaling as key effectors...
June 13, 2017: Current Osteoporosis Reports
https://www.readbyqxmd.com/read/28609314/feedback-simulation-for-acupressure-training-and-skill-assessment
#5
Eric Noll, Jamie Romeiser, Shivam Shodhan, Maria Cecilia Madariaga, Xiaojun Guo, Sabeen Rizwan, Ehab Al-Bizri, Elliott Bennett-Guerrero
INTRODUCTION: Previous acupressure studies have yielded varying results. This could be due to differences in the amount of pressure applied to the acupressure point (acupoint) by study personnel within a study as well as between studies. Standardizing the level of pressure applied at an acupoint could improve clinical care and future research. METHODS: As part of an ongoing randomized clinical trial of postoperative acupressure, five trainees were asked to perform 2 minutes of acupressure and light touch sessions on a simulator...
June 12, 2017: Simulation in Healthcare: Journal of the Society for Simulation in Healthcare
https://www.readbyqxmd.com/read/28605952/migration-of-contraceptive-implant-into-the-left-pulmonary-arterial-system
#6
Ee Phui Kew, Eshan Senanayake, Madava Djearaman, Ehab Bishay
An 18-year-old woman had an etonogestrel implant inserted into her left upper arm 2 years earlier for menorrhagia. Her symptoms were not well controlled and she requested the implant to be removed. However, clinicians were unable to locate the implant on her left arm. Computed tomography showed that the implant had migrated to a sub-lobar branch of the left lower lobe pulmonary artery. The long-term effect of leaving an etonogestrel implant in the pulmonary arterial system is unknown. This report adds to the small body of evidence on intravascular migration of a subdermally placed contraceptive implant...
January 1, 2017: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/28602553/proteomic-profiling-of-the-brain-of-mice-with-experimental-cerebral-malaria
#7
Ehab Moussa, Honglei Huang, Malika Ahras, Amar Lall, Marie L Thezenas, Roman Fischer, Benedikt M Kessler, Arnab Pain, Oliver Billker, Climent Casals-Pascual
Cerebral malaria (CM) is a severe neurological complication of malaria infection in both adults and children. In pursuit of effective treatment of CM, clinical studies, postmortem analysis and animal models have been employed to understand the pathology and identify effective interventions. In this study, a shotgun proteomics analysis was conducted to profile the proteomic signature of the brain tissue of mice with experimental cerebral malaria (ECM) in order to further understand the underlying pathology. To identify CM-associated response, proteomic signatures of the brains of C57/Bl6N mice infected with P...
June 5, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28597306/maintenance-of-remission-with-combination-etanercept-dmard-therapy-versus-dmards-alone-in-active-rheumatoid-arthritis-results-of-an-international-treat-to-target-study-conducted-in-regions-with-limited-biologic-access
#8
Karel Pavelka, Nurullah Akkoç, Mustafa Al-Maini, Cristiano A F Zerbini, Dmitry E Karateev, Evgeny L Nasonov, Mahboob U Rahman, Ronald Pedersen, Andrew Dinh, Qi Shen, Radu Vasilescu, Sameer Kotak, Ehab Mahgoub, Bonnie Vlahos
In this transglobal, randomized, double-blind, placebo-controlled, treat-to-target study, the maintenance of efficacy was compared between biologic-and biologic-free-disease-modifying antirheumatic drug (DMARD) combination regimens after low disease activity (LDA) was achieved with biologic DMARD induction therapy. Patients with moderate-to-severe rheumatoid arthritis despite methotrexate therapy received open-label etanercept 50 mg subcutaneously once weekly plus methotrexate with or without other conventional synthetic (cs) DMARDs for 24 weeks...
June 9, 2017: Rheumatology International
https://www.readbyqxmd.com/read/28589109/laryngo-tracheo-bronchial-foreign-bodies-in-children-clinical-presentations-and-complications
#9
Hazem-Saeed Amer, Mohammad-Waheed El-Anwar, Ashraf Raafat, Mohamed AlShawadfy, Ehab Sobhy, Samir-Attia Ahmed, Ahmed-Ma Maaty
INTRODUCTION: Foreign-body (FB) aspiration in the airway of children is a life-threatening clinical situation responsible for many deaths each year. The aim of this study was to evaluate the different clinical presentations, methods of diagnosis, types and complications of FB inhalation in the pediatric age group. MATERIALS AND METHODS: The study included patients who presented with a definitive or suspicious history of FB aspiration. Detailed data for each patient were recorded concerning the age, sex, nature and site of the FB, presenting symptoms and signs, and radiological findings...
May 2017: Iranian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28582423/correction-the-impact-of-anti-drug-antibodies-on-drug-concentrations-and-clinical-outcomes-in-rheumatoid-arthritis-patients-treated-with-adalimumab-etanercept-or-infliximab-results-from-a-multinational-real-world-clinical-practice-non-interventional-study
#10
Robert J Moots, Ricardo M Xavier, Chi Chiu Mok, Mahboob U Rahman, Wen-Chan Tsai, Mustafa H Al-Maini, Karel Pavelka, Ehab Mahgoub, Sameer Kotak, Joan Korth-Bradley, Ron Pedersen, Linda Mele, Qi Shen, Bonnie Vlahos
[This corrects the article DOI: 10.1371/journal.pone.0175207.].
2017: PloS One
https://www.readbyqxmd.com/read/28561956/outcomes-for-olfactory-neuroblastoma-treated-with-induction-chemotherapy
#11
Shirley Y Su, Diana Bell, Renata Ferrarotto, Jack Phan, Dianna Roberts, Michael E Kupferman, Steven J Frank, C Dave Fuller, G Brandon Gunn, Merrill S Kies, Bonnie S Glisson, Ehab Y Hanna
BACKGROUND: Oncologic outcomes for induction chemotherapy and its role in patients with advanced olfactory neuroblastoma (ONB) remain unclear. METHODS: A retrospective review of 15 consecutive patients with extensive local invasion and/or nodal disease treated with induction chemotherapy with curative intent followed by definitive local therapy. RESULTS: The majority of patients were treated with cisplatin and etoposide. The response to chemotherapy was 68% (10/15)...
May 31, 2017: Head & Neck
https://www.readbyqxmd.com/read/28561719/chronic-myeloid-leukemia-what-every-practitioner-needs-to-know-in-2017
#12
Hanna Jean Khoury, Loretta A Williams, Ehab Atallah, Rüdiger Hehlmann
The prognosis of chronic phase chronic myeloid leukemia (CML) has improved so that life expectancy for patients responding to tyrosine kinase inhibitors (TKIs) is now equivalent to age-matched controls. Attention should be paid to comorbidities that impact survival. The success of TKI therapy can be easily and reliably assessed at well-accepted time points using quantitative polymerase chain reaction (PCR) standardized to the international scale. Patient-reported outcome (PRO) tools are readily available for use in the clinic and provide complementary information on the tolerance of TKIs...
2017: American Society of Clinical Oncology Educational Book
https://www.readbyqxmd.com/read/28552437/tofacitinib-an-oral-janus-kinase-inhibitor-in-patients-from-mexico-with-rheumatoid-arthritis-pooled-efficacy-and-safety-analyses-from-phase-3-and-lte-studies
#13
Ruben Burgos-Vargas, Mario Cardiel, Daniel Xibillé, César Pacheco-Tena, Virginia Pascual-Ramos, Carlos Abud-Mendoza, Ehab Mahgoub, Mahboob Rahman, Haiyun Fan, Ricardo Rojo, Erika García, Karina Santana
OBJECTIVES: Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid arthritis (RA). We characterized efficacy and safety of tofacitinib in Mexican patients from RA Phase 3 and long-term extension (LTE) studies. METHODS: Data from Mexican patients with RA and an inadequate response to disease-modifying antirheumatic drugs (DMARDs) were taken from four Phase 3 studies (pooled across studies) and one open-label LTE study of tofacitinib. Patients received tofacitinib 5 or 10mg twice daily, adalimumab (one Phase 3 study) or placebo (four Phase 3 studies) as monotherapy or in combination with conventional synthetic DMARDs...
May 25, 2017: Reumatología Clinica
https://www.readbyqxmd.com/read/28543275/the-role-of-itpa-and-ribavirin-transporter-genes-polymorphisms-in-prediction-of-ribavirin-induced-anemia-in-chronic-hepatitis-c-egyptian-patients
#14
Ehab S El Desoky, Alaa T Abdelhafez, Jessica Cusato, Sherif I Kamel, Abeer M R Hussein, Amedeo De Nicolo, Giovanni Di Perri, Antonio D'Avolio
Few data are available concerning the roles of polymorphisms of inosine triphosphatase (ITPA) gene and ribavirin (RBV) transporter genes in the prediction of RBV-induced anemia among Egyptians with chronic hepatitis C (CHC). Genotyping of 3 ITPA gene variants and 2 variants of RBV transporter genes has been performed in 123 patients under pegylated interferon-α/ribavirin treatment. The baseline hemoglobin and ITPA rs1127354 CA/AA have been found as predictors of anemia at 4, 8 and 12 weeks of RBV therapy. In addition, ITPA rs7270101 AC/CC and age predicted anemia after 12 weeks of therapy...
May 24, 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/28532702/trimetazidine-in-the-prevention-of-contrast-induced-nephropathy-in-chronic-kidney-disease
#15
Tarek A Ibrahim, Ramzy H El-Mawardy, Ahmed S El-Serafy, Ehab M El-Fekky
BACKGROUND: Contrast induced nephropathy (CIN) may be defined as Acute Renal Failure (ARF) that occurs within 24-72h of exposure to intra-venous or intra-arterial iodinated contrast media that cannot be attributed to other causes. CIN occurs in up to 5% of hospitalized patients with normal renal function prior to injection of contrast media. It occurs more frequently in patients with renal impairment particularly if associated with diabetic nephropathy. Among all procedures utilizing contrast agents for either diagnostic or therapeutic purposes, coronary angiography and percutaneous coronary interventions are associated with the highest rates of CIN...
February 10, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28521942/regulation-development-and-evolution-of-caste-ratios-in-the-hyperdiverse-ant-genus-pheidole
#16
REVIEW
Angelica Lillico-Ouachour, Ehab Abouheif
Ant colonies are considered complex biological systems because many individuals are divided into different castes that interact to efficiently perform their tasks. Colonies in the hyperdiverse ant genus Pheidole have evolved a worker caste with at least two subcastes: soldiers and minor workers. The proportion of soldiers and minor workers in a colony has a major impact on the colony's fitness and is tightly regulated. Here, we summarize over 100 years of research on the internal, external, and developmental factors that regulate subcaste production as well as influence subcaste evolution in Pheidole...
February 2017: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/28498141/the-asa-committee-for-neuroanesthesia-and-anesthesia-quality-institute-report-for-demographic-patterns-for-neurosurgical-anesthesia-practice-in-the-united-states
#17
Ehab Farag, Benjamin Westlake, Richard P Dutton, Edward J Mascha, W Andrew Kofke
No abstract text is available yet for this article.
May 11, 2017: Journal of Neurosurgical Anesthesiology
https://www.readbyqxmd.com/read/28494469/mutation-status-among-patients-with-sinonasal-mucosal-melanoma-and-its-impact-on-survival
#18
Moran Amit, Samantha Tam, Ahmed S Abdelmeguid, Dianna B Roberts, Yoko Takahashi, Shaan M Raza, Shirley Y Su, Michael E Kupferman, Franco DeMonte, Ehab Y Hanna
BACKGROUND: Sinonasal mucosal melanoma (SNMM) comprises <1% of all melanomas and lacks well-characterised molecular markers. Our aim was to determine the frequencies of common mutations and examine their utility as molecular markers in a large series of primary SNMMs. METHODS: SNMM patients seen at our institution from August 1991 through July 2016 were identified. Genomic DNA was extracted from 66 formalin-fixed paraffin-embedded tumours and screened for mutations by direct sequencing...
June 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28486043/randomized-phase-ii-study-of-azacitidine-alone-or-in-combination-with-lenalidomide-or-with-vorinostat-in-higher-risk-myelodysplastic-syndromes-and-chronic-myelomonocytic-leukemia-north-american-intergroup-study-swog-s1117
#19
Mikkael A Sekeres, Megan Othus, Alan F List, Olatoyosi Odenike, Richard M Stone, Steven D Gore, Mark R Litzow, Rena Buckstein, Min Fang, Diane Roulston, Clara D Bloomfield, Anna Moseley, Aziz Nazha, Yanming Zhang, Mario R Velasco, Rakesh Gaur, Ehab Atallah, Eyal C Attar, Elina K Cook, Alyssa H Cull, Michael J Rauh, Frederick R Appelbaum, Harry P Erba
Purpose Azacitidine is standard, first-line therapy in higher-risk myelodysplastic syndromes (MDS). Whether azacitidine-based combinations with lenalidomide or vorinostat produce superior overall response rates (ORRs) to azacitidine is not known. Patients and Methods North American Intergroup Study S1117 is a phase II/III trial that randomly assigned patients with higher-risk MDS and chronic myelomonocytic leukemia (CMML) 1:1:1 to azacitidine (75 mg/m(2)/day on days 1 to 7 of a 28-day cycle); azacitidine plus lenalidomide (10 mg/day on days 1 to 21); or azacitidine plus vorinostat (300 mg twice daily on days 3 to 9)...
May 9, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28479767/reimbursements-and-frequency-of-tests-in-privately-insured-testicular-cancer-patients-in-the-united-states-implications-to-national-guidelines
#20
Mohamed H Kamel, Austin Barber, Rodney Davis, Omer A Raheem, Nabil Bissada, Alaa Eldin A Abdelmaksoud, Ehab Eltahawy
OBJECTIVES: The objective of this study was to assess the frequency of utilization and reimbursement of the common diagnostic tests and treatment modalities used in testicular cancer care. METHODS: LifeLink™ (IMS Health, Danbury, CT, USA) Claims Database was used. We identified 877 subjects with a primary diagnosis of testicular cancer (ICD 186.9) between 2007 and 2012. Median reimbursement and frequency of the diagnostic/treatment modalities used were recorded...
April 2017: Urology Annals
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