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https://www.readbyqxmd.com/read/29205772/the-exploitation-of-enzymatically-derived-cis-1-2-dihydrocatechols-and-related-compounds-in-the-synthesis-of-biologically-active-natural-products
#1
REVIEW
Ehab S Taher, Martin G Banwell, Joshua N Buckler, Qiao Yan, Ping Lan
The title compounds of the general form 1 can be produced at large scale and in essentially enantiomerically pure form (when X≠H) through the whole cell biotransformation of the corresponding aromatic. The "dense" and varied functionality associated with these metabolites mean that they have become increasingly useful chirons for the total synthesis of a range of natural product types. This personal account details the outcomes of a nearly three-decade long campaign within our group to exploit these compounds in the synthesis of a diverse range of small molecule natural product targets...
December 4, 2017: Chemical Record: An Official Publication of the Chemical Society of Japan ... [et Al.]
https://www.readbyqxmd.com/read/29200130/diffuse-retinal-vascular-leakage-and-cone-rod-dystrophy-in-a-family-with-the-homozygous-missense-c-1429g-a-p-gly477arg-mutation-in-crb1
#2
Hamed Al Sulaiman, Patrik Schatz, Sawsan R Nowilaty, Ehab Abdelkader, Leen Abu Safieh
PURPOSE: To describe a specific cone-rod dystrophy phenotype in a family with the homozygous c.1429G>A; p.Gly477Arg mutation in CRB1. The detailed phenotype of subjects with this specific mutation has not been described previously. METHODS: Clinical examination included full-field electroretinography and high-resolution and widefield retinal imaging and uveitis workup. Molecular genetic analysis included next-generation sequencing of known retinal dystrophy genes and Sanger sequencing for segregation analysis...
December 1, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/29192533/cardiovascular-mortality-trends-in-non-hodgkin-s-lymphoma-a-population-based-cohort-study
#3
Mohamed Gomaa Kamel, Amr Ehab El-Qushayri, Tran Quang Thach, Nguyen Tien Huy
BACKGROUND: Non-Hodgkin's lymphoma (NHL) survivors are at a higher risk of cardiovascular diseases (CVDs). METHODS: A population-based study was conducted to investigate the cardiovascular mortality trends to identify NHL survivors at the highest risk. RESULTS: The CVDs mortality was the second most common cause of death (13.07%) after NHL. There were more patients ≥ 60 years old in the cardiovascular group (87.2%), P < 0.001. Patients who died from CVDs had the best survival while patients who died from NHL had a significantly lower mean survival...
December 1, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29190092/structure-based-design-and-biological-characterization-of-selective-histone-deacetylase-8-hdac8-inhibitors-with-anti-neuroblastoma-activity
#4
Tino Heimburg, Fiona R Kolbinger, Patrik Zeyen, Ehab Ghazy, Daniel Herp, Karin Schmidtkunz, Jelena Melesina, Tajith Baba Shaik, Frank Erdmann, Matthias Schmidt, Christophe Romier, Dina Robaa, Olaf Witt, Ina Oehme, Manfred Jung, Wolfgang Sippl
Histone deacetylases (HDACs) are important modulators of epigenetic gene regulation and additionally control the activity of non-histone protein substrates. While for HDACs 1-3 and 6 many potent selective inhibitors have been obtained, for other subtypes much less is known on selective inhibitors and the consequences of their inhibition. The present report describes the development of substituted benzhydroxamic acids as potent and selective HDAC8 inhibitors. Docking studies using available crystal structures have been used for structure-based optimization of this series of compounds...
November 30, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29188367/traumatic-vertebral-artery-rupture-causing-intraspinal-hematoma-and-progressive-neurological-symptoms
#5
Ehab Shiban, Bernhard Meyer
Traumatic vertebral artery rupture is extremely rare. Herein, we report a case of traumatic vertebral artery rupture causing extensive intraspinal hematoma and progressive neurological symptoms.
November 30, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29184452/violence-toward-health-workers-in-bahrain-defense-force-royal-medical-services-emergency-department
#6
Faisal Rafeea, Ahmed Al Ansari, Ehab M Abbas, Khalifa Elmusharaf, Mohamed S Abu Zeid
Background: Employees working in emergency departments (EDs) in hospital settings are disproportionately affected by workplace violence as compared to those working in other departments. Such violence results in minor or major injury to these workers. In other cases, it leads to physical disability, reduced job performance, and eventually a nonconducive working environment for these workers. Materials and methods: A cross-sectional exploratory questionnaire was used to collect data used for the examination of the incidents of violence in the workplace...
2017: Open Access Emergency Medicine: OAEM
https://www.readbyqxmd.com/read/29169353/correction-to-long-term-patient-reported-outcomes-following-radiation-therapy-for-oropharyngeal-cancer-cross-sectional-assessment-of-a-prospective-symptom-survey-in-patients-%C3%A2-65%C3%A2-years-old
#7
Salman A Eraj, Mona K Jomaa, Crosby D Rock, Abdallah S R Mohamed, Blaine D Smith, Joshua B Smith, Theodora Browne, Luke C Cooksey, Bowman Williams, Brandi Temple, Kathryn E Preston, Jeremy M Aymard, Neil D Gross, Randal S Weber, Amy C Hessel, Renata Ferrarotto, Jack Phan, Erich M Sturgis, Ehab Y Hanna, Steven J Frank, William H Morrison, Ryan P Goepfert, Stephen Y Lai, David I Rosenthal, Tito R Mendoza, Charles S Cleeland, Kate A Hutcheson, Clifton D Fuller, Adam S Garden, G Brandon Gunn
In the original publication [1] the name of author Jeremy M. Aymard was spelled wrong. The original article was updated to rectify this error.
November 23, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29158767/screening-of-shox-gene-sequence-variants-in-saudi-arabian-children-with-idiopathic-short-stature
#8
Abdulla A Alharthi, Ehab I El-Hallous, Iman M Talaat, Hamed A Alghamdi, Matar I Almalki, Ahmed Gaber
Purpose: Short stature affects approximately 2%-3% of children, representing one of the most frequent disorders for which clinical attention is sought during childhood. Despite assumed genetic heterogeneity, mutations or deletions in the short stature homeobox-containing gene (SHOX) are frequently detected in subjects with short stature. Idiopathic short stature (ISS) refers to patients with short stature for various unknown reasons. The goal of this study was to screen all the exons of SHOX to identify related mutations...
October 2017: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/29156366/triterpenoidal-saponins-from-the-fruits-of-gleditsia-caspica-with-proapoptotic-properties
#9
Usama Shaheen, Ehab A Ragab, Ashraf N Abdalla, Ammar Bader
Three previously undescribed oleanane-type triterpenoidal saponins named caspicaosides L-N were isolated from the fruits of Gleditsia caspica Desf. The aglycons of these saponins were echinocystic acid, erythrodiol and 12-oleanene-3,28,30-triol. Caspicaoside L is a bisdesmosidic saponin acylated with two monoterpenic acids. It has a disaccharide moiety made up of glucose and arabinose attached to C-3 and pentasaccharide moiety linked to C-28 made up of one glucose, 2 xyloses, one inner rhamnose and one terminal rhamnose which was acylated with two identical monoterpenic acids...
November 17, 2017: Phytochemistry
https://www.readbyqxmd.com/read/29153279/corrigendum-to-neuroprotective-role-of-ginkgo-biloba-against-cognitive-deficits-associated-with-bisphenol-a-exposure-an-animal-model-study-neurochem-int-108-2017-199-212
#10
Manar Mohammed El Tabaa, Samia Salem Sokkar, Ehab Sayed Ramadan, Inas Zakria Abd El Salam, Anis Zaid
No abstract text is available yet for this article.
November 15, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/29149089/mnsod-and-cyclin-b1-coordinate-a-mito-checkpoint-during-cell-cycle-response-to-oxidative-stress
#11
Amanda L Kalen, Iman M Ahmad, Maher Y Abdalla, Yunxia Q O'Malley, Prabhat C Goswami, Ehab H Sarsour
Communication between the nucleus and mitochondrion could coordinate many cellular processes. While the mechanisms regulating this communication are not completely understood, we hypothesize that cell cycle checkpoint proteins coordinate the cross-talk between nuclear and mitochondrial functions following oxidative stress. Human normal skin fibroblasts, representative of the G₂-phase, were irradiated with 6 Gy of ionizing radiation and assayed for cyclin B1 translocation, mitochondrial function, reactive oxygen species (ROS) levels, and cytotoxicity...
November 17, 2017: Antioxidants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29142805/role-of-adjuvant-treatment-in-sinonasal-mucosal-melanoma
#12
Moran Amit, Samantha Tam, Ahmed S Abdelmeguid, Michael E Kupferman, Shirley Y Su, Shaan M Raza, Franco DeMonte, Ehab Y Hanna
Purpose  Sinonasal mucosal melanoma (SNMM) is a locally aggressive tumor. This study aimed to define the role of adjuvant treatment and its association with survival outcomes of SNMM. Methods  This retrospective study investigated 152 patients with SNMM treated between 1991 and 2016 in MD Anderson Cancer Center. Patients were divided into the following treatment groups: surgery alone, surgery with postoperative radiotherapy (PORT), surgery with postoperative chemoradiation (POCRT), and induction chemotherapy followed by surgery and PORT...
December 2017: Journal of Neurological Surgery. Part B, Skull Base
https://www.readbyqxmd.com/read/29131280/the-sphenopalatine-foramen-in-man-anatomical-radiological-and-endoscopic-study
#13
Ehab Abdel Aziz El-Shaarawy, Sherif S Hassan
BACKGROUND: Epistaxis is a frequent problem otorhinolaryngologists faces of in their practice. The variations of the sphenopalatine foramen and consequently the artery may be one of the major sources of such bleeding. AIM OF THE WORK: The present work aimed at to localize the site of sphenopalatine foramen and also to illustrate its different shapes, number and any other variation. MATERIALS AND METHODS: In the current study, twenty adult skulls of both sexes with total 40 half skulls were used in addition to 20 heads of adult living subjects of both sexes aged between 30-60 years examined with multislice helical CT with 3-D reconstruction of SPF...
November 13, 2017: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29104794/retroperitoneal-varix-ligation-with-sclerotherapy-a-prospective-randomized-comparative-study
#14
Yaser M Abdelsalam, Waleed M Saeed, Ahmed M Moeen, Ehab O Elganainy, Abdelfatah I Ahmed
Introduction: The aim of this article is to compare the results of high varix ligation with and without sclerotherapy. Material and methods: Between November 2014 and December 2015, sixty patients with varicocele were included in this study. Patients were divided into two equal groups; group I (underwent high varix ligation), and group II (underwent high varix ligation with a retrograde injection of 2 mL of 5% ethanolamine oleate in the lower end of the bisected gonadal vein)...
2017: Central European Journal of Urology
https://www.readbyqxmd.com/read/29097875/trends-and-outcomes-of-pancreaticoduodenectomy-for-periampullary-tumors-a-25-year-single-center-study-of-1000-consecutive-cases
#15
Ayman El Nakeeb, Waleed Askar, Ehab Atef, Ehab El Hanafy, Ahmad M Sultan, Tarek Salah, Ahmed Shehta, Mohamed El Sorogy, Emad Hamdy, Mohamed El Hemly, Ahmed A El-Geidi, Tharwat Kandil, Mohamed El Shobari, Talaat Abd Allah, Amgad Fouad, Mostafa Abu Zeid, Ahmed Abu El Eneen, Nabil Gad El-Hak, Gamal El Ebidy, Omar Fathy, Ahmed Sultan, Mohamed Abdel Wahab
AIM: To evaluate the evolution, trends in surgical approaches and reconstruction techniques, and important lessons learned from performing 1000 consecutive pancreaticoduodenectomies (PDs) for periampullary tumors. METHODS: This is a retrospective review of the data of all patients who underwent PD for periampullary tumor during the period from January 1993 to April 2017. The data were categorized into three periods, including early period (1993-2002), middle period (2003-2012), and late period (2013-2017)...
October 14, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29093686/what-s-in-a-typeface-evidence-of-the-existence-of-print-personalities-in-arabic
#16
Timothy R Jordan, Alya S AlShamsi, Hajar A K Yekani, Maryam AlJassmi, Nada Al Dosari, Ehab W Hermena, Mercedes Sheen
Previous research suggests that different typefaces can be perceived as having distinct personality characteristics (such as strength, elegance, friendliness, romance, and humor) and that these "print personalities" elicit information in the reader that is in addition to the meaning conveyed linguistically by words. However, research in this area has previously been conducted using only English stimuli and so it may be that typefaces in English, and other languages using the Latinate alphabet, lend themselves unusually well to eliciting perception of print personalities, and the phenomenon is not a language universal...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29090101/plasmablastic-lymphoma-case-report-of-prolonged-survival-of-an-advanced-human-immunodeficiency-patient-and-literature-review
#17
Hind Rafei, Ehab El-Bahesh, Antoine Finianos, Min-Ling L Liu, Geraldine P Schechter
Clinical Practice Points. Plasmablastic lymphoma (PBL) is a rare and highly aggressive variant of diffuse large B cell lymphoma with median survival of advanced stage patients varying between 6 and 15 months in previous reports. We report here a human immunodeficiency virus-infected patient surviving over 12 years following treatment for advanced PBL with EPOCH chemotherapy and intrathecal therapy. This case highlights the potential for improved survival in PBL with intensive chemotherapy. Further, literature review suggests promising prospects utilizing novel targeted therapies to increase the rate of prolonged responses...
2017: Case Reports in Hematology
https://www.readbyqxmd.com/read/29075906/symptomatic-annulus-repair-device-loosening-due-to-a-low-grade-infection
#18
Nicole Lange, Bernhard Meyer, Ehab Shiban
We report the unusual case of a young patient with reoperation after annuloplasty using the Barricaid® (Intrinsic Therapeutics, Woburn, MA, USA) closure device. Our patient, a 32-year-old man underwent lumbar discectomy and annuloplasty of the level L5-S1. Five years later, the patient presented with a new onset of low-back pain radiating into the right leg. Imaging revealed loosening of the annulus repair device. The device was removed surgically and the patient was pain free thereafter. Annular closure devices such as the Barricaid system aim to improve outcome after lumbar discectomy by reducing the risk of recurrent disc herniation of the same level...
October 26, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29071158/lingual-mucosal-graft-two-stage-bracka-technique-for-redo-hypospadias-repair
#19
Ahmed Sakr, Ehab Elkady, Mohamed Abdalla, Amr Fawzi, Mostafa Kamel, Esam Desoky, Mohamed Seleem, Mohamed Omran, Ehab Elsayed, Salem Khalil
OBJECTIVES: To report our initial experience in redo hypospadias repair with a lingual mucosal graft (LMG) using a two-stage Bracka technique. PATIENTS AND METHODS: This study was prospectively conducted and included 26 patients with hypospadias with failed previous repairs. All the patients had a LMG using a two-stage Bracka technique. In the first stage, the harvested LMG, from the ventro-lateral surface of the tongue, was implanted in a well-prepared vascularised bed in the ventral aspect of the penis...
September 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/29068756/long-term-effect-of-pulsed-nd-yag-laser-combined-with-exercise-on-bone-mineral-density-in-men-with-osteopenia-or-osteoporosis-1-year-of-follow-up
#20
Mohamed Salaheldien Mohamed Alayat, Ehab Mohamed Abdel-Kafy, Ali Abdel Monsif Thabet, Ahmed Salman Abdel-Malek, Tariq Helmi Ali, Eslam A Header
BACKGROUND: A pulsed Nd-YAG laser is an effective physiotherapy modality used as a class IV high-intensity laser therapy (HILT). PURPOSE: The aim of this study is to investigate the efficacy of HILT alone or combined with exercise (HILT+EX) on bone mineral density (BMD) after 24 weeks and at 1 year of follow-up in men with osteopenia or osteoporosis. METHODS: One hundred men with osteopenia or osteoporosis (mean age, 53.78 [2.89] years; weight, 80...
October 25, 2017: Photomedicine and Laser Surgery
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