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Marwa A Mohamed, Ehab I Mohamed, Samir A Abd El-Kaream, Mohamed I Badawi, Samy H Darwish
BACKGROUND: Evidence is increasing that microRNAs (miR) are particularly important in lung homeostasis and development and have been shown to be involved in many pulmonary diseases such as asthma, chronic obstructive pulmonary disease, sarcoidosis, lung cancer (LC) and other smoking-related diseases. OBJECTIVE: The objective of this study was to investigate the expression of miR-155 and miR-486-5p in tissues from LC patients and healthy endobronchial mucosa as prognostic biomarkers for diagnosing LC...
February 12, 2018: MicroRNA
Ehab S Eshak, Hiroyasu Iso, Kazumasa Yamagishi, Renzhe Cui, Akiko Tamakoshi
OBJECTIVES: A few reports have investigated the association of dietary vitamin intakes with risk of heart failure in Asia. Therefore, we examined the relation between dietary intakes of fat-soluble vitamins A, K, E, and D and mortality from heart failure in the Japanese population. METHODS: A total of 23 099 men and 35 597 women ages 40 to 79 y participated in the Japan Collaborative Cohort Study and completed a food frequency questionnaire from which dietary intakes of vitamins A, K, E, and D were calculated...
March 2018: Nutrition
Seung-Hun Lee, Ehab Mossaad, Abdalla Mohamed Ibrahim, Ahmed Ali Ismail, Paul Franck Adjou Moumouni, Mingming Liu, Aaron Edmond Ringo, Yang Gao, Huanping Guo, Jixu Li, Artemis Efstratiou, Peter Musinguzi, Tamador E E Angara, Keisuke Suganuma, Noboru Inoue, Xuenan Xuan
Tick-borne pathogens (TBPs) are common in livestock of sub-Saharan Africa. However, information regarding TBPs in sheep and goats in Sudan is limited. In this study, 178 blood samples of sheep and goats in Blue Nile and West Kordofan states were investigated for TBPs using PCR. Overall, 110 (61.8%) samples were found to be infected with at least one of the following pathogens: Anaplasma ovis, Theileria ovis, and Ehrlichia ruminantium. Babesia ovis and T. lestoquardi were not identified. A. ovis was the most prevalent pathogen (n = 107, 60...
February 1, 2018: Ticks and Tick-borne Diseases
Ehab Rasmy Bendas, Mamdouh R Rezk, Kamal A Badr
BACKGROUND AND OBJECTIVES: The purpose of this study was to apply the reference-scaled average bioequivalence (RSABE) approach to evaluate the bioequivalence and to investigate the pharmacokinetic properties of two formulations of fixed dose combination (FDC) tablet of sofosbuvir (SOF) and ledipasvir (LED) (400/90 mg) in 36 healthy Egyptian volunteers. METHODS: The study was performed in single-dose, randomized-sequence, open-label, reference-replicated, 3-period crossover design (RTR, TRR, RRT), with a washout period of 2 weeks...
February 7, 2018: Clinical Drug Investigation
Ehab Shiban, Jens Lehmberg, Ute Hoffmann, Jeff Thiel, Thomas Probst, Margret Friedl, Andreas Mühlberger, Bernhard Meyer, Youssef Shiban
Background: Growing evidence shows the significance of illness and surgical procedures as traumatizing stressors. Risk factors are widely investigated in various settings and samples, using numerous measures of posttraumatic stress and posttraumatic stress disorder (PTSD). While pretrauma psychological distress is acknowledged as an influential factor, peritraumatic experiences are controversially still being discussed as relevant to the development of PTSD. Objective: In a group of patients consecutively undergoing elective spine surgery (N = 89) in a German hospital, this longitudinal study addressed the question of how pretrauma PTSD symptoms and peritrauma distress interact with one another in regard to the amount of posttrauma symptoms of PTSD...
2018: European Journal of Psychotraumatology
Ehab F Elkady, Marwa A Fouad, Bushra M Jaadan
A new validated bio-analytical LC-MS/MS method was developed for the simultaneous extraction and determination of four proton pump inhibitors: esomeprazole, lansoprazole, pantoprazole and rabeprazole in human plasma using escitalopram as an internal standard. The proteins in plasma samples were precipitated using acetonitrile for the extraction of analytes which is a simple economic method. The separation was accomplished using a mobile phase composed of 10 mM ammonium formate: acetonitrile: methanol (20:40:40% v/v) at a flow rate of 0...
February 15, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Rana Refaat Makar, Randa Latif, Ehab Ahmed Hosni, Omaima Naim El Gazayerly
Purpose: Triple solid dispersion adsorbates (TSDads) and spherical agglomerates (SA) present new techniques that extensively enhance dissolution of poorly soluble drugs. The aim of the present study is to hasten the onset of hypoglycemic effect of glimepiride through enhancing its rate of release from tablet formulation prepared from either technique. Methods: Drug release from TSDads or SA tablets with different added excipients was explored. Scanning electron microscopy (SEM) and effect of compression on dissolution were illustrated...
December 2017: Advanced Pharmaceutical Bulletin
Moataz Ehab Mohamed, Nagla Mohy, Sarah Salah
AIMS: The Survey aimed to capture the perceptions of undergraduate pharmacy students towards plagiarism in three major public universities in Cairo, Egypt; Helwan, Ain-Shams, and Cairo Universities. METHODS: This was a paper- based self-administrated survey study. The questionnaire was validated by both content and face validation. The final survey form captured the knowledge of the students on plagiarism definition, attitudes and practicing of plagiarism. RESULTS: Four hundred and fourteen students, 320 females and 94 males, participated in the study...
February 4, 2018: Accountability in Research
Nicola Oswald, John Hardman, Amy Kerr, Ehab Bishay, Richard Steyn, Pala Rajesh, Maninder Kalkat, Babu Naidu
BACKGROUND: Receiving information about their disease and treatment is very important to patients with cancer. There is an association between feeling appropriately informed and better quality of life. This audit aimed to estimate patient satisfaction with perioperative information in those undergoing surgery for lung cancer and any change in satisfaction over time. METHODS: A questionnaire (EORTC-Info-25) was administered prospectively to patients preoperatively and up to six months postoperatively...
February 1, 2018: Journal of Cardiothoracic Surgery
Ehab Hanafy, Duaa Alshareef, Suhaila Osman, Abdullah Al Jabri, Faisal Nazim, Gihan Mahmoud
BACKGROUND: Posterior reversible encephalopathy syndrome is a neurotoxic condition that occurs as a result of the failure of posterior circulatory autoregulation in response to acute changes in blood pressure. Overperfusion with resultant disruption of the blood-brain barrier results in vasogenic edema, but not infarction. Posterior reversible encephalopathy syndrome can be the presenting feature of postinfectious glomerulonephritis, which has been reported in approximately 5% of hospitalized children, and it has been reported in very few cases of adult patients with sickle cell anemia...
February 1, 2018: Journal of Medical Case Reports
Joshua Montroy, Ehab Elzayat, Chris Morash, Brian Blew, Luke T Lavallée, Ilias Cagiannos, James Watterson, Jeffrey S Oake, Michael Fungkeefung, Calvin Thompson, Robert Weber, Rodney H Breau
INTRODUCTION: There is concern that surgical quality initially declines during the learning phase of robotic surgery. At our institution, we used a multi-surgeon programmatic approach to the introduction of robotic surgery. The purpose of this study was to evaluate outcomes of patients treated during the first year of our program. METHODS: This is a historical cohort of all radical prostatectomy patients during a one-year period. Baseline, perioperative, and long-term followup data were prospectively and retrospectively collected...
December 1, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Salem S Alghamdi, Muhammad A Khan, Ehab H El-Harty, Megahed H Ammar, Muhammad Farooq, Hussein M Migdadi
This study aimed to estimate the proximate, phenolic and flavonoids contents and phytochemicals present in seeds of twenty four soybeans (Glycine max (L.) Merr) genotypes to explore their nutritional and medicinal values. Crude protein composition ranged between 35.63 and 43.13% in Argentinian and USA (Clark) genotypes, respectively. Total phenolic content varied from 1.15 to 1.77 mg GAE/g, whereas flavonoids varied from 0.68 to 2.13 mg QE/g. The GC-MS analysis resulted identification of 88 compounds categorized into aldehydes (5), ketones (13), alcohols (5), carboxylic acids (7), esters (13), alkanes (2), heterocyclic compounds (19), phenolic compound (9), sugar moiety (7) ether (4) and amide (3), one Alkene and one fatty acid ester...
January 2018: Saudi Journal of Biological Sciences
Moshe Talpaz, Giuseppe Saglio, Ehab Atallah, Philippe Rousselot
Chronic myeloid leukemia (CML) has evolved into a chronic disease that is managed with tyrosine kinase inhibitor therapy. Now that long-term survival has been achieved in patients with CML, the focus of treatment has shifted to dose optimization, with the goal of maintaining response while improving quality of life. In this review, the authors discuss optimizing the dose of the second-generation tyrosine kinase inhibitor dasatinib. Once-daily dosing regimens for dasatinib in the first and later lines of treatment were established through long-term (5-year and 7-year) trials...
January 25, 2018: Cancer
Sebastian Ille, Thomas Picht, Ehab Shiban, Bernhard Meyer, Peter Vajkoczy, Sandro M Krieg
BACKGROUND: The treatment of brain arteriovenous malformations (BAVMs) is still contrarily discussed. Despite the debatable results of the ARUBA trial, most BAVMs still require treatment depending on the Spetzler-Martin (SM) grading. Since size is measurable and venous drainage is visible, the determination of eloquence is comparably crucial but not fully objective. The present bicentric cohort study aims to examine the influence of preoperative navigated transcranial magnetic stimulation (nTMS) motor and language mapping data on decision-making for or against surgical treatment of BAVMs...
March 2018: Acta Neurochirurgica
Ehab Mohamed Gedawy
Novel 4-substitutedaminothieno[2,3-d]pyrimidine derivatives 4a-i and 5a-c were synthesized via reacting corresponding 4-chlorothieno[2,3-d]pyrimidine derivatives 3a-c with N-methylpiperazine, morpholine, N-phenylpiperazine or 1,3-propanediamine. All of the newly synthesized compounds were submitted to the National Cancer Institute (USA) for anticancer evaluation. Six compounds (2a, 4d, 4e, 5a-c) were selected and evaluated using 60 different human tumor cell lines using a single dose (10-5 Molar). Compound 4d showed significant cytotoxicity against colon, renal, prostate and breast cancer...
January 24, 2018: Anti-cancer Agents in Medicinal Chemistry
Mohamed Ahmed Fathi, Ehab M Esheiba, Ani Purushothaman
No abstract text is available yet for this article.
August 2017: Atherosclerosis
Anisha Dubey, Laura Izakelian, Ehab A Ayaub, Lilian Ho, Kyle Stephenson, Steven Wong, Karen Kwofie, Richard C Austin, Fernando Botelho, Kjetil Ask, Carl D Richards
Arginase-1 (Arg-1)-expressing M2-like macrophages are associated with Th2-skewed immune responses, allergic airway pathology, ectopic B16 melanoma cancer growth in murine models, and can be induced by Oncostatin M (OSM) transient overexpression in vivo. Here, we compare OSM to the gp130-cytokine IL-6 in mediating macrophage polarization, and find that IL-6 overexpression alone (Ad vector, AdIL-6) did not induce Arg-1 protein in mouse lungs at day 7, nor ectopic melanoma tumor growth at day 14, in contrast to overexpression of OSM (AdOSM)...
November 27, 2017: Immunology and Cell Biology
Ehab Saad Aldin, Parren McNeely, Yusuf Menda
We present a case of posterior reversible encephalopathy syndrome (PRES) in a pediatric patient with Burkitt's lymphoma predominantly involving the bone marrow. F-FDG PET/CT scan obtained after the first cycle of chemotherapy, complicated by acute kidney injury, hypertension, tumor lysis syndrome, and lethargy with focal neurological symptoms, showed a favorable marrow and lymph node response but increased FDG uptake in the bilateral frontal and occipital cortical/subcortical regions. Brain MRI was consistent with PRES...
January 19, 2018: Clinical Nuclear Medicine
Samuel Samnick, Ehab Al-Momani, Jan-Stefan Schmid, Anja Mottok, Andreas K Buck, Constantin Lapa
AIM: Recently, [F]tetrafluoroborate ([F]TFB) has been introduced as a versatile PET probe for imaging the human sodium/iodide symporter activity. This pilot study aimed to compare [F]TFB-PET/CT with [I]NaI-PET/CT imaging in thyroid cancer patients. METHODS: Nine patients with newly diagnosed differentiated thyroid cancer underwent both [F]TFB- and [I]NaI-PET/CT after total thyroidectomy. PET/CT scans were visually analyzed for the presence of remnant thyroid tissue and for metastatic lesions on a patient and lesion basis...
January 19, 2018: Clinical Nuclear Medicine
Ehab A AlBadawy, Ashirbani Saha, Maciej A Mazurowski
BACKGROUND AND PURPOSE: Convolutional neural networks (CNNs) are increasingly common for segmentation of brain tumors. In this work, we assess the effect of cross-institutional training on the performance of CNNs. METHODS: We selected 44 glioblastoma (GBM) patients from two institutions in The Cancer Imaging Archive dataset. The images were manually annotated by outlining each tumor component to form ground truth. To segment the tumors in each patient, we trained three CNNs: (a) one using data for patients from the same institution as the test data, (b) one using data for the patients from the other institution and (c) one using data for the patients from both of the institutions...
January 22, 2018: Medical Physics
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