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Thrombosed plaque

Vu Hoang, Jill Grounds, Don Pham, Salim Virani, Ihab Hamzeh, Athar Mahmood Qureshi, Nasser Lakkis, Mahboob Alam
The development of multiple diagnostic intracoronary imaging modalities has increased our understanding of coronary atherosclerotic disease. These imaging modalities, intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near-infrared spectroscopy (NIRS), have provided a method to study plaques and introduced the concept of plaque vulnerability. They are being increasingly used for percutaneous coronary intervention (PCI) optimization and are invaluable tools in research studying the pathophysiology of acute coronary syndrome (ACS), in-stent thrombosis and in-stent restenosis...
September 2016: Current Atherosclerosis Reports
Fabio Settecase, Andrew D Nicholson, Matthew R Amans, Randall T Higashida, Van V Halbach, Daniel L Cooke, Christopher F Dowd, Steven W Hetts
A 13-year-old boy with meningiomatosis, McCune-Albright syndrome, and gray platelet syndrome presented with an enlarging "lump" on his right forehead. A head CT scan revealed a polyostotic fibrous dysplasia involving the entire skull. A 3.4-cm right frontal osseous cavity and an overlying right forehead subcutaneous soft-tissue mass were seen, measuring 5.2 cm in diameter and 1.6 cm thick. Ultrasound of the cavity and overlying mass showed swirling of blood and an arterialized waveform. MRI revealed an en plaque meningioma underlying the cavity...
March 2016: Journal of Neurosurgery. Pediatrics
Mohammad Reza Kazemian, Atefeh Solouk, Aaron Tan, Alexander M Seifalian
Atherosclerosis is one of the major cause of mortality in developed countries. The characteristic lesion of atherosclerosis is the atheroma or plaque that forms through thickening of the inner layer of the vessel wall (called the intima). The development of stent in 1980s revolutionised treatment of cardiovascular diseases, including atherosclerosis. However the advent of stenting was hindered by the new problem of in-stent restenosis. It was demonstrated that in-stent restenosis was the result of a new pathology in the form of neointimal hyperplasia, which was a maladaptive healing response to bare-metal stent implantation...
December 2015: Medical Hypotheses
Kazim Husain, Wilfredo Hernandez, Rais A Ansari, Leon Ferder
Atherosclerosis is a chronic inflammatory disease associated with cardiovascular dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke and peripheral thromboses. It has been predicted that atherosclerosis will be the primary cause of death in the world by 2020. Atherogenesis is initiated by endothelial injury due to oxidative stress associated with cardiovascular risk factors including diabetes mellitus, hypertension, cigarette smoking, dyslipidemia, obesity, and metabolic syndrome...
August 26, 2015: World Journal of Biological Chemistry
Katarzyna Michaud, Silke Grabherr, Mohamed Faouzi, Jochen Grimm, Francesco Doenz, Patrice Mangin
The goal of this study was to assess the localization and types of thrombosed plaques in cases of sudden cardiac death attributed to coronary artery disease and to evaluate possible correlations with body mass index (BMI) and increased heart weight. This retrospective study was performed on forensic cases for which the cause of death was attributed to coronary artery disease. A complete autopsy and a multi-phase postmortem computed tomography (CT) angiography (MPMCTA) were performed in all cases. Eighty-five cases were selected (mean age, 55...
September 2015: International Journal of Legal Medicine
Ming-Duo Zhang, Xue-Cheng Zhao, Yu-Hui Zhang, Yun-Feng Yan, Zheng-Ming Wang, Shu-Zheng Lv, Quan-Ming Zhao
INTRODUCTION: The relationship between the beneficial effects of pioglitazone in reducing clinical events and plaque inflammatory burden remains unknown. This study aimed to determine whether pioglitazone can reduce the number of plaque thrombosis incidences and whether decreasing plaque inflammation is the mechanism by which pioglitazone reduces plaque thromboses. METHODS AND RESULTS: therosclerotic rabbits were divided into two groups: the atherosclerosis group (n = 13) and pioglitazone group (n = 10)...
June 2015: Cardiovascular Therapeutics
Masataka Nakano, Kazuyuki Yahagi, Fumiyuki Otsuka, Kenichi Sakakura, Aloke V Finn, Robert Kutys, Elena Ladich, David R Fowler, Michael Joner, Renu Virmani
OBJECTIVES: The study interrogated an autopsy registry to investigate the histopathologic features of early stent thrombosis (ST) in patients presenting with acute coronary syndrome (ACS). BACKGROUND: The occurrence of early ST following percutaneous coronary intervention (PCI) for ACS remains a clinical problem despite advances in stent technology in both bare-metal and drug-eluting stents. METHODS: Sixty-seven stented coronary lesions from 59 patients who presented with ACS and died within 30 days were included...
June 17, 2014: Journal of the American College of Cardiology
B Malgras, A Mlynski, C Pierret, S Fossat, X de Kérangal
INTRODUCTION: Hypothenar hammer syndrome is a rare cause of upper extremity digital ischemia or Raynaud phenomenon, a diagnosis which should be considered in cases of iterative palmar trauma. Its treatment can be medical or surgical and should not suffer any delay. The best options remain controversial. METHODS: A 65-year-old patient presented with an ischemia of the last three fingers of the left hand. A partially thrombosed aneurysm of the left ulnar artery was diagnosed at imaging...
May 2014: Journal des Maladies Vasculaires
Sebastian Michel, Christian Hagl, Gerd Juchem, Ralf Sodian
BACKGROUND: The management of type A intramural hematoma (IMH) is controversial. Although most Western countries still recommend immediate surgical repair, some centers in Asia have shown good results recently with medical treatment alone. Here, we present a case of type A IMH which was discovered during the operation to be a thrombosed type A dissection. CASE REPORT: An 83-year-old female patient presented with acute chest pain. After diagnostic exclusion of myocardial infarction, computed tomography was performed, which showed an IMH from the ascending to the descending aorta...
December 2013: Heart Surgery Forum
Sibel Güler, Çiğdem Deniz, Ufuk Utku, Sezgin Kehaya
Spontaneous intracranial hypotension was first described by Schalternbarn. Severe complications like cerebral venous thrombosis and subdural hemorrhage are seldomly seen. A 40-year-old man was examined for weakness of right arm started 9 months earlier and aggravated in last 3 months. He was undergo a lumbar punction because of a demyelinating plaque at C2 level in MRI. After 10 days of lumbar punction he experienced a generalised tonic clonic seizure. At cranial MRI and venography thrombosed superior sagittal and right transverse sinus and image of pachymeningitis, caused by intracranial hypotension were observed...
2013: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
Xin Zhao, Quan-ming Zhao, Ting-ting Feng, De-peng Li, Yu Liu, Li-qin Li, Ming-duo Zhang, Xu-cui Zhuang, Xue-cheng Zhao
OBJECTIVE: To investigate the feasibility of identifying the vulnerable plaque and predicting plague rupture and thrombus using by positron emission tomography/computed tomography angiography (PET/CTA). METHODS: Twenty-eight male New Zealand white rabbits were fed with hyper-lipid diet for 2 weeks before the balloon injury of the abdominal aorta.Then these rabbit were intermittently fed with hyper-lipid diet for 14 weeks, in order to trigger pharmaceutic the plague rupture and thrombus...
May 21, 2013: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Salvatore Ronsivalle, Francesca Faresin, Francesca Franz, Luigi Pedon, Carlo Rettore, Loretta Zonta, Armando Olivieri
BACKGROUND: Lower extremity ischemia for limb thrombosis is a well-known adverse event after endovascular abdominal aortic aneurysm repair (EVAR), ranging from 2.6-7.4%. We report our experience in the management of graft limb occlusion that occurred in patients who underwent EVAR in our institution. In cases in which balloon catheter thrombectomy is not useful or is risky, it is important to take into consideration the use of a Vollmar ring stripper (Aesculap, San Jose, CA) to avoid dislodging or disrupting the sealing zones...
November 2013: Annals of Vascular Surgery
Beat J Meyer, Claeys
Our perception of the mechanisms underlying the acute complications of atherosclerosis has significantly changed in the last decade. Most coronary thromboses result from a rupture or a fissure in the protective fibrous cap of atherosclerotic plaque, but less common from a superficial erosion. The extent of thrombosis is a determinant of the clinical picture of acute coronary syndromes. Until now, we held a high grade stenosis responsible for the vast majority of acute coronary syndromes. However, current findings establish the relevance of qualitative aspects of plaques as important determinants of the vulnerability of plaques, i...
February 1, 2002: Therapeutische Umschau. Revue Thérapeutique
Sazzli Kasim, Darragh Moran, Eugene McFadden
Critical coronary stenoses accounts for a small proportion of acute coronary syndromes and sudden death. The majority are caused by coronary thromboses that arise from a nonangiographically obstructive atheroma. Recent developments in noninvasive imaging of so-called vulnerable plaques created opportunities to direct treatment to prevent morbidity and mortality associated with these high-risk lesions. This review covers therapy employed in the past, present, and potentially in the future as the natural history of plaque assessment unfolds...
October 2012: Heart Views: the Official Journal of the Gulf Heart Association
Hossein Mehrad, Manijhe Mokhtari-Dizaji, Hossein Ghanaati, Amir-Ali Shahbazfar, Afshin Mohsenifar
BACKGROUND: A precise understanding of the mechanism of human neointimal stenoses and atherosclerotic fibrous plaques, which give rise to thromboses in vital arteries, requires a suitable animal model that would mimic the same characteristics well. We developed a rabbit model of neointimal stenosis and fibrotic plaque rupture in the carotid artery to visualize the lesion progress and to characterize the lesion types according to the American Heart Association classification. METHODS: Twenty-eight healthy male New Zealand white rabbits were randomly divided into two groups: The rabbits in group A (n = 14) consumed a standard chow diet, and those in group B (n = 14) were injured via perivascular cold injury using liquid nitrogen at the right common carotid artery before being fed a high cholesterol diet (1...
2011: Journal of Tehran Heart Center
Sundararajan Srikanth, John A Ambrose
Atherosclerosis is a systemic vascular pathology that is preceded by endothelial dysfunction. Vascular inflammation "fuels" atherosclerosis and creates the milieu for episodes of intravascular thromboses. Thrombotic events in the coronary vasculature may lead to asymptomatic progression of atherosclerosis or could manifest as acute coronary syndromes or even sudden cardiac death. Thrombus encountered in the setting of acute coronary syndromes has been correlated with acute complications during percutaneous coronary interventions such as no-reflow, acute coronary occlusion and long term complications such as stent thrombus...
August 2012: Current Cardiology Reviews
Troels Thim, Mette Kallestrup Hagensen, Arne Hørlyck, Ludovic Drouet, William P Paaske, Hans Erik Bøtker, Erling Falk
BACKGROUND: Accelerated atherosclerosis is the main cause of late aortocoronary vein graft failure. We aimed to develop a large animal model for the study of pathogenesis and treatment of vein graft atherosclerosis. METHODS: An autologous reversed jugular vein graft was inserted end-to-end into the transected common carotid artery of ten hypercholesteroemic minipigs. The vein grafts were investigated 12-14 weeks later with ultrasound and angiograpy in vivo and microscopy post mortem...
2012: BMC Cardiovascular Disorders
Youngchai Ko, Wook-Joo Kim, Myung Suk Jang, Mi Hwa Yang, Jung Hyun Park, Sang Il Choi, Eun Ju Chun, Soo Joo Lee, Moon-Ku Han, Hee-Joon Bae
BACKGROUND AND PURPOSE: Multidetector-row CT (MDCT) is emerging as a new tool for diagnosing aortic atherothrombotic disease (AAD). We elucidated whether MDCT-detected AAD is associated with an increased risk of early ischemic lesion recurrence on diffusion-weighted MRI after ischemic stroke. METHODS: A consecutive series of patients with acute ischemic stroke confirmed using diffusion-weighted MRI who were hospitalized within 48 hours after symptom onset and underwent MDCT were identified in a prospective stroke registry database...
March 2012: Stroke; a Journal of Cerebral Circulation
D Laganà, G Carrafiello, D Lumia, F Fontana, M Mangini, F A Vizzari, G Piffaretti, C Fugazzola
PURPOSE: This study sought to assess the effectiveness of rotational thrombectomy (RT) with the Rotarex device in the treatment of thrombotic occlusions in native arteries, by-pass grafts, stents and stent-grafts. MATERIALS AND METHODS: Over the last 4 years, 22 patients (14 men and 8 women; mean age 62.6 years) affected by 5 acute (<14 days) thrombotic occlusions of the native arteries (4 plaque thromboses in the common iliac artery and one on a dissection intimal flap of the external iliac artery), 17 subacute and chronic thromboses affecting 4 femoro-popliteal by-pass grafts, 10 stents (7 in the common iliac artery and 3 in the superficial femoral artery) and 3 stents-grafts were studied...
September 2011: La Radiologia Medica
Fabio Tavora, Ling Li, Mary Ripple, David Fowler, Allen Burke
There are few pathologic descriptions of fatal coronary artery disease in the young. The morphologic characteristics of sudden coronary deaths in 47 hearts from patients younger than 40 years were studied. Numbers of plaques with necrotic cores were quantitated in each heart. Compared to 194 sudden coronary deaths >40 years, heart weight was lower, acute plaque erosions more frequent, and extent of disease less in the ≤40 years group. Plaque burden was less in hearts with erosions, and healed infarcts more common in hearts with stable plaque...
2010: Pathology Research International
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