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https://www.readbyqxmd.com/read/28487316/atheroma-susceptible-to-thrombosis-exhibit-impaired-endothelial-permeability-in-vivo-as-assessed-by-nanoparticle-based-fluorescence-molecular-imaging
#1
Ashley F Stein-Merlob, Tetsuya Hara, Jason R McCarthy, Adam Mauskapf, James A Hamilton, Vasilis Ntziachristos, Peter Libby, Farouc A Jaffer
BACKGROUND: The role of local alterations in endothelial functional integrity in atherosclerosis remains incompletely understood. This study used nanoparticle-enhanced optical molecular imaging to probe in vivo mechanisms involving impaired endothelial barrier function in experimental atherothrombosis. METHODS AND RESULTS: Atherosclerosis was induced in rabbits (n=31) using aortic balloon injury and high-cholesterol diet. Rabbits received ultrasmall superparamagnetic iron oxide nanoparticles (CLIO) derivatized with a near-infrared fluorophore (CyAm7) 24 hours before near-infrared fluorescence imaging...
May 2017: Circulation. Cardiovascular Imaging
https://www.readbyqxmd.com/read/28383307/the-thrombolytic-effect-of-diagnostic-ultrasound-induced-microbubble-cavitation-in-acute-carotid-thromboembolism
#2
Thomas R Porter, Feng Xie, John Lof, Jeffry Powers, Francois Vignon, William Shi, Matthew White
BACKGROUND: Acute ischemic stroke is often due to thromboembolism forming over ruptured atherosclerotic plaque in the carotid artery (CA). The presence of intraluminal CA thrombus is associated with a high risk of thromboembolic cerebral ischemic events. The cavitation induced by diagnostic ultrasound high mechanical index (MI) impulses applied locally during a commercially available intravenous microbubble infusion has dissolved intravascular thrombi, especially when using longer pulse durations...
August 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28300680/evaluation-by-magnetic-resonance-imaging-of-silent-brain-infarcts-in-preoperative-and-postoperative-asymptomatic-carotid-surgery
#3
Remy Pascot, Anne Daoudal, Alain Cardon, Gilles Godet, Antoine Lucas, Elodie Clochard, Jean-Yves Gauvrit, Yann Le Teurnier, Adrien Kaladji
BACKGROUND: To report the prevalence of silent brain infarcts (SBI) at magnetic resonance imaging (MRI) before and after surgery for asymptomatic high grade carotid stenosis. METHODS: This is a single center retrospective observational study. Asymptomatic patients who underwent carotid endarterectomy between October 2012 and October 2014 were included. The preoperative assessment included a Doppler and a computed tomographic (CT) scan dating less than 3 months...
August 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28154268/heterogeneous-intravascular-ultrasound-findings-of-stent-thrombosis
#4
Toru Morofuji, Shinji Inaba, Hiroe Aisu, Kayo Takahashi, Makoto Saito, Haruhiko Higashi, Toyofumi Yoshii, Takumi Sumimoto
Objective The underlying mechanisms of stent thrombosis are not completely understood. Methods We experienced 12 definite stent thrombosis cases (1 early, 1 late, and 10 very late) at our hospital from July 2011 to April 2016 and evaluated the possible causes of stent thrombosis by intravascular ultrasound (IVUS). Results Five different potential morphological causes of stent thrombosis (neoatherosclerosis, stent malapposition, stent fracture, edge dissection, and stent underexpansion) were detected by IVUS in 10 cases (83...
2017: Internal Medicine
https://www.readbyqxmd.com/read/28124228/the-role-of-msct-angiography-in-early-detection-of-lower-limb-arterial-lesions-in-patients-with-antiphospholipid-syndrome
#5
Jovica Saponjski, Ljudmila Stojanovich, Jelena Petrovic, Dusan Saponjski
Antiphospholipid syndrome (APS) is an autoimmune disease which is characterized by arterial and venous thromboses, fetal loss, and the presence of antiphospholipid antibodies in the serum. It is characterized by accelerated atherosclerosis. Increased tendency towards thrombosis leads to the occurrence of various vascular events. The objective of our study was to determine if there are subclinical changes on lower limb arteries in APS patients and what the best diagnostic choice for their establishment is. In this study, we analyzed 50 patients with primary antiphospholipid syndrome (PAPS) and 50 patients, who have secondary antiphospholipid syndrome (SAPS)...
January 25, 2017: Immunologic Research
https://www.readbyqxmd.com/read/27485540/the-role-of-intracoronary-plaque-imaging-with-intravascular-ultrasound-optical-coherence-tomography-and-near-infrared-spectroscopy-in-patients-with-coronary-artery-disease
#6
REVIEW
Vu Hoang, Jill Grounds, Don Pham, Salim Virani, Ihab Hamzeh, Athar Mahmood Qureshi, Nasser Lakkis, Mahboob Alam
The development of multiple diagnostic intracoronary imaging modalities has increased our understanding of coronary atherosclerotic disease. These imaging modalities, intravascular ultrasound (IVUS), optical coherence tomography (OCT), and near-infrared spectroscopy (NIRS), have provided a method to study plaques and introduced the concept of plaque vulnerability. They are being increasingly used for percutaneous coronary intervention (PCI) optimization and are invaluable tools in research studying the pathophysiology of acute coronary syndrome (ACS), in-stent thrombosis and in-stent restenosis...
September 2016: Current Atherosclerosis Reports
https://www.readbyqxmd.com/read/26588455/onyx-embolization-of-an-intraosseous-pseudoaneurysm-of-the-middle-meningeal-artery-in-a-patient-with-meningiomatosis-mccune-albright-syndrome-and-gray-platelet-syndrome
#7
Fabio Settecase, Andrew D Nicholson, Matthew R Amans, Randall T Higashida, Van V Halbach, Daniel L Cooke, Christopher F Dowd, Steven W Hetts
A 13-year-old boy with meningiomatosis, McCune-Albright syndrome, and gray platelet syndrome presented with an enlarging "lump" on his right forehead. A head CT scan revealed a polyostotic fibrous dysplasia involving the entire skull. A 3.4-cm right frontal osseous cavity and an overlying right forehead subcutaneous soft-tissue mass were seen, measuring 5.2 cm in diameter and 1.6 cm thick. Ultrasound of the cavity and overlying mass showed swirling of blood and an arterialized waveform. MRI revealed an en plaque meningioma underlying the cavity...
March 2016: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/26364047/preventing-in-stent-restenosis-using-lipoprotein-a-lipid-and-cholesterol-adsorbent-materials
#8
Mohammad Reza Kazemian, Atefeh Solouk, Aaron Tan, Alexander M Seifalian
Atherosclerosis is one of the major cause of mortality in developed countries. The characteristic lesion of atherosclerosis is the atheroma or plaque that forms through thickening of the inner layer of the vessel wall (called the intima). The development of stent in 1980s revolutionised treatment of cardiovascular diseases, including atherosclerosis. However the advent of stenting was hindered by the new problem of in-stent restenosis. It was demonstrated that in-stent restenosis was the result of a new pathology in the form of neointimal hyperplasia, which was a maladaptive healing response to bare-metal stent implantation...
December 2015: Medical Hypotheses
https://www.readbyqxmd.com/read/26322175/inflammation-oxidative-stress-and-renin-angiotensin-system-in-atherosclerosis
#9
REVIEW
Kazim Husain, Wilfredo Hernandez, Rais A Ansari, Leon Ferder
Atherosclerosis is a chronic inflammatory disease associated with cardiovascular dysfunction including myocardial infarction, unstable angina, sudden cardiac death, stroke and peripheral thromboses. It has been predicted that atherosclerosis will be the primary cause of death in the world by 2020. Atherogenesis is initiated by endothelial injury due to oxidative stress associated with cardiovascular risk factors including diabetes mellitus, hypertension, cigarette smoking, dyslipidemia, obesity, and metabolic syndrome...
August 26, 2015: World Journal of Biological Chemistry
https://www.readbyqxmd.com/read/25904078/pathomorphological-and-ct-angiographical-characteristics-of-coronary-atherosclerotic-plaques-in-cases-of-sudden-cardiac-death
#10
Katarzyna Michaud, Silke Grabherr, Mohamed Faouzi, Jochen Grimm, Francesco Doenz, Patrice Mangin
The goal of this study was to assess the localization and types of thrombosed plaques in cases of sudden cardiac death attributed to coronary artery disease and to evaluate possible correlations with body mass index (BMI) and increased heart weight. This retrospective study was performed on forensic cases for which the cause of death was attributed to coronary artery disease. A complete autopsy and a multi-phase postmortem computed tomography (CT) angiography (MPMCTA) were performed in all cases. Eighty-five cases were selected (mean age, 55...
September 2015: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/25825053/plaque-thrombosis-is-reduced-by-attenuating-plaque-inflammation-with-pioglitazone-and-is-evaluated-by-fluorodeoxyglucose-positron-emission-tomography
#11
Ming-Duo Zhang, Xue-Cheng Zhao, Yu-Hui Zhang, Yun-Feng Yan, Zheng-Ming Wang, Shu-Zheng Lv, Quan-Ming Zhao
INTRODUCTION: The relationship between the beneficial effects of pioglitazone in reducing clinical events and plaque inflammatory burden remains unknown. This study aimed to determine whether pioglitazone can reduce the number of plaque thrombosis incidences and whether decreasing plaque inflammation is the mechanism by which pioglitazone reduces plaque thromboses. METHODS AND RESULTS: therosclerotic rabbits were divided into two groups: the atherosclerosis group (n = 13) and pioglitazone group (n = 10)...
June 2015: Cardiovascular Therapeutics
https://www.readbyqxmd.com/read/24768883/causes-of-early-stent-thrombosis-in-patients-presenting-with-acute-coronary-syndrome-an-ex-vivo-human-autopsy-study
#12
Masataka Nakano, Kazuyuki Yahagi, Fumiyuki Otsuka, Kenichi Sakakura, Aloke V Finn, Robert Kutys, Elena Ladich, David R Fowler, Michael Joner, Renu Virmani
OBJECTIVES: The study interrogated an autopsy registry to investigate the histopathologic features of early stent thrombosis (ST) in patients presenting with acute coronary syndrome (ACS). BACKGROUND: The occurrence of early ST following percutaneous coronary intervention (PCI) for ACS remains a clinical problem despite advances in stent technology in both bare-metal and drug-eluting stents. METHODS: Sixty-seven stented coronary lesions from 59 patients who presented with ACS and died within 30 days were included...
June 17, 2014: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/24720999/-hypothenar-hammer-syndrome-case-report-and-review-of-the-literature
#13
REVIEW
B Malgras, A Mlynski, C Pierret, S Fossat, X de Kérangal
INTRODUCTION: Hypothenar hammer syndrome is a rare cause of upper extremity digital ischemia or Raynaud phenomenon, a diagnosis which should be considered in cases of iterative palmar trauma. Its treatment can be medical or surgical and should not suffer any delay. The best options remain controversial. METHODS: A 65-year-old patient presented with an ischemia of the last three fingers of the left hand. A partially thrombosed aneurysm of the left ulnar artery was diagnosed at imaging...
May 2014: Journal des Maladies Vasculaires
https://www.readbyqxmd.com/read/24370806/type-a-intramural-hematoma-often-turns-out-to-be-a-type-a-dissection
#14
Sebastian Michel, Christian Hagl, Gerd Juchem, Ralf Sodian
BACKGROUND: The management of type A intramural hematoma (IMH) is controversial. Although most Western countries still recommend immediate surgical repair, some centers in Asia have shown good results recently with medical treatment alone. Here, we present a case of type A IMH which was discovered during the operation to be a thrombosed type A dissection. CASE REPORT: An 83-year-old female patient presented with acute chest pain. After diagnostic exclusion of myocardial infarction, computed tomography was performed, which showed an IMH from the ascending to the descending aorta...
December 2013: Heart Surgery Forum
https://www.readbyqxmd.com/read/24104538/a-case-of-cerebral-venous-thrombosis-accompanying-with-intracranial-hypotension-headache-that-changing-character
#15
Sibel Güler, Çiğdem Deniz, Ufuk Utku, Sezgin Kehaya
Spontaneous intracranial hypotension was first described by Schalternbarn. Severe complications like cerebral venous thrombosis and subdural hemorrhage are seldomly seen. A 40-year-old man was examined for weakness of right arm started 9 months earlier and aggravated in last 3 months. He was undergo a lumbar punction because of a demyelinating plaque at C2 level in MRI. After 10 days of lumbar punction he experienced a generalised tonic clonic seizure. At cranial MRI and venography thrombosed superior sagittal and right transverse sinus and image of pachymeningitis, caused by intracranial hypotension were observed...
2013: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/24029566/-noninvasive-imaging-of-vulnerable-plaques-and-thromboses-with-pet-ct-complex-imaging-technique
#16
Xin Zhao, Quan-ming Zhao, Ting-ting Feng, De-peng Li, Yu Liu, Li-qin Li, Ming-duo Zhang, Xu-cui Zhuang, Xue-cheng Zhao
OBJECTIVE: To investigate the feasibility of identifying the vulnerable plaque and predicting plague rupture and thrombus using by positron emission tomography/computed tomography angiography (PET/CTA). METHODS: Twenty-eight male New Zealand white rabbits were fed with hyper-lipid diet for 2 weeks before the balloon injury of the abdominal aorta.Then these rabbit were intermittently fed with hyper-lipid diet for 14 weeks, in order to trigger pharmaceutic the plague rupture and thrombus...
May 21, 2013: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/24011815/a-new-management-for-limb-graft-occlusion-after-endovascular-aneurysm-repair-adding-a-vollmar-ring-stripper-the-unclogging-technique
#17
Salvatore Ronsivalle, Francesca Faresin, Francesca Franz, Luigi Pedon, Carlo Rettore, Loretta Zonta, Armando Olivieri
BACKGROUND: Lower extremity ischemia for limb thrombosis is a well-known adverse event after endovascular abdominal aortic aneurysm repair (EVAR), ranging from 2.6-7.4%. We report our experience in the management of graft limb occlusion that occurred in patients who underwent EVAR in our institution. In cases in which balloon catheter thrombectomy is not useful or is risky, it is important to take into consideration the use of a Vollmar ring stripper (Aesculap, San Jose, CA) to avoid dislodging or disrupting the sealing zones...
November 2013: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/23491665/-mechanisms-of-acute-coronary-syndromes-the-unstable-plaque
#18
Beat J Meyer, Claeys
Our perception of the mechanisms underlying the acute complications of atherosclerosis has significantly changed in the last decade. Most coronary thromboses result from a rupture or a fissure in the protective fibrous cap of atherosclerotic plaque, but less common from a superficial erosion. The extent of thrombosis is a determinant of the clinical picture of acute coronary syndromes. Until now, we held a high grade stenosis responsible for the vast majority of acute coronary syndromes. However, current findings establish the relevance of qualitative aspects of plaques as important determinants of the vulnerability of plaques, i...
February 1, 2002: Therapeutische Umschau. Revue Thérapeutique
https://www.readbyqxmd.com/read/23439781/vulnerable-plaque-from-bench-to-bedside-local-pacification-versus-systemic-therapy
#19
Sazzli Kasim, Darragh Moran, Eugene McFadden
Critical coronary stenoses accounts for a small proportion of acute coronary syndromes and sudden death. The majority are caused by coronary thromboses that arise from a nonangiographically obstructive atheroma. Recent developments in noninvasive imaging of so-called vulnerable plaques created opportunities to direct treatment to prevent morbidity and mortality associated with these high-risk lesions. This review covers therapy employed in the past, present, and potentially in the future as the natural history of plaque assessment unfolds...
October 2012: Heart Views: the Official Journal of the Gulf Heart Association
https://www.readbyqxmd.com/read/23074617/developing-a-rabbit-model-of-neointimal-stenosis-and-atherosclerotic-fibrous-plaque-rupture
#20
Hossein Mehrad, Manijhe Mokhtari-Dizaji, Hossein Ghanaati, Amir-Ali Shahbazfar, Afshin Mohsenifar
BACKGROUND: A precise understanding of the mechanism of human neointimal stenoses and atherosclerotic fibrous plaques, which give rise to thromboses in vital arteries, requires a suitable animal model that would mimic the same characteristics well. We developed a rabbit model of neointimal stenosis and fibrotic plaque rupture in the carotid artery to visualize the lesion progress and to characterize the lesion types according to the American Heart Association classification. METHODS: Twenty-eight healthy male New Zealand white rabbits were randomly divided into two groups: The rabbits in group A (n = 14) consumed a standard chow diet, and those in group B (n = 14) were injured via perivascular cold injury using liquid nitrogen at the right common carotid artery before being fed a high cholesterol diet (1...
2011: Journal of Tehran Heart Center
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