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REM sleep disorder

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https://www.readbyqxmd.com/read/29237551/dose-dependent-and-opposite-effects-of-orexin-a-on-prepulse-inhibition-response-in-sleep-deprived-and-non-sleep-deprived-rats
#1
Pınar Öz, H Kübra Gökalp, Tansu Göver, Tayfun Uzbay
Orexin is a novel neurotransmitter released from lateral hypothalamus, that is a crucial modulator in sleep/wakefulness system. Recent studies also suggest its possible role in the neurodevelopmental disorders, such as schizophrenia. Our study consists of two experiments, where we investigate the effect of orexin A (OXA), one of two isoforms of orexin that can pass blood brain barrier, on the prepulse inhibition of acoustic startle reflex. The first experiment tested the effect of OXA on PPI response of non-sleep-deprived rats via intraperitoneal injection 30min before testing...
December 10, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29235907/a-validation-study-of-fitbit-charge-2%C3%A2-compared-with-polysomnography-in-adults
#2
Massimiliano de Zambotti, Aimee Goldstone, Stephanie Claudatos, Ian M Colrain, Fiona C Baker
We evaluated the performance of a consumer multi-sensory wristband (Fitbit Charge 2™), against polysomnography (PSG) in measuring sleep/wake state and sleep stage composition in healthy adults. In-lab PSG and Fitbit Charge 2™ data were obtained from a single overnight recording at the SRI Human Sleep Research Laboratory in 44 adults (19-61 years; 26 women; 25 Caucasian). Participants were screened to be free from mental and medical conditions. Presence of sleep disorders was evaluated with clinical PSG...
December 13, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29234278/effects-of-social-defeat-stress-on-sleep-in-mice
#3
Fiona Henderson, Vincent Vialou, Salah El Mestikawy, Véronique Fabre
Stress plays a key role in the development of psychiatric disorders and has a negative impact on sleep integrity. In mice, chronic social defeat stress (CSDS) is an ethologically valid model of stress-related disorders but little is known about its effects on sleep regulation. Here, we investigated the immediate and long-term effects of 10 consecutive days of social defeat (SD) on vigilance states in C57Bl/6J male mice. Social behavior was assessed to identify susceptible mice, i.e., mice that develop long-lasting social avoidance, and unsusceptible mice...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/29232183/loss-of-substantia-nigra-hyperintensity-at-3-0-t-mr-imaging-in-idiopathic-rem-sleep-behavior-disorder-comparison-with-123i-fp-cit-spect
#4
Yun Jung Bae, Jong-Min Kim, Kyeong Joon Kim, Eunhee Kim, Hyun Soo Park, Seo Young Kang, In-Young Yoon, Jee-Young Lee, Beomseok Jeon, Sang Eun Kim
Purpose To examine whether the loss of nigral hyperintensity (NH) on 3.0-T susceptibility-weighted (SW) magnetic resonance (MR) images can help identify high synucleinopathy risk in patients with idiopathic rapid eye movement sleep behavior disorder (iRBD). Materials and Methods Between March 2014 and April 2015, 18 consecutively recruited patients with iRBD were evaluated with 3.0-T SW imaging and iodine 123-2β-carbomethoxy-3β-(4-iodophenyl)-N-(3-fluoropropyl)-nortropane (123I-FP-CIT) single photon emission computed tomography and compared with 18 healthy subjects and 18 patients with Parkinson disease (PD)...
December 12, 2017: Radiology
https://www.readbyqxmd.com/read/29222639/sleep-related-painful-erections-following-sexual-intercourse
#5
Pieter C Barnhoorn, Woet L Gianotten, Mels F van Driel
Sleep-related painful erections (SRPE) is a rare disorder characterized by recurrent painful nocturnal erections during REM sleep in the absence of pain during daytime erections. Approximately 35 cases of SRPE have been reported in the literature, none of them associated with preceding sexual intercourse. We add the report of a 40-year-old patient with a 6-year history of SRPE which only, but always, occurred after sexual intercourse with ejaculation in the evening before. As a result, the frequency of intercourse diminished, causing relationship problems...
December 8, 2017: Archives of Sexual Behavior
https://www.readbyqxmd.com/read/29216391/prevalence-and-determinants-of-rem-sleep-behavior-disorder-in-the-general-population
#6
José Haba-Rubio, Birgit Frauscher, Pedro Marques-Vidal, Jérôme Toriel, Nadia Tobback, Daniela Andries, Martin Preisig, Peter Vollenweider, Ronald Postuma, Raphaël Heinzer
Study Objectives: REM sleep behavior disorder (RBD) is a parasomnia associated with neurodegenerative synucleinopathies. Its prevalence is largely unknown. This study determined the prevalence and characteristics of RBD in the general population using gold-standard polysomnography. Methods: Full polysomnographic data from 1997 subjects (age=59±11.1 years, 53.6% women) participating in a population-based study (HypnoLaus, Lausanne, Switzerland) were collected. Sleep-related complaints and habits were investigated using various sleep measures including the Munich Parasomnia Screening (MUPS) questionnaire, which includes two questions evaluating complex motor behaviors suggestive of RBD...
December 5, 2017: Sleep
https://www.readbyqxmd.com/read/29213045/-an-effect-of-epilepsy-on-sleep-structure
#7
S G Khachatryan, Yu S Tunyan
In this review, the authors discuss the problem of management of the patient with epilepsy with regard an impact of epileptic seizures and syndromes on sleep structure. Sleep disorders can lead to worsening of seizure control and general medical condition of the patients. However, seizures themselves and types of epilepsy can affect the sleep architecture. One of the most frequent symptoms of disordered sleep in epilepsy patients is excessive daytime sleepiness, which can be a consequence of poor sleep quality due to frequent nocturnal seizures or excessive interictal epileptiform activity during sleep leading to frequent arousals...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/29182727/an-ambulatory-psg-study-of-the-posttraumatic-nightmares-of-posttraumatic-stress-disorder
#8
Andrea J Phelps, Richard A A Kanaan, Christopher Worsnop, Suzy Redston, Naomi Ralph, David Forbes
Study Objectives: This study used ambulatory polysomnography (PSG) to investigate posttraumatic nightmares of PTSD. The key research question was whether posttraumatic nightmares occur in both REM and non-REM sleep, and if so, whether nightmares in each sleep stage differed in content, phenomenology and heart rate response. Underlying sleep disorders were investigated in an exploratory way. Methods: Thirty-five treatment-seeking veterans, current serving military members and emergency service personnel undertook full PSG using the Compumedics (Melbourne, Australia) SomtePSG V1 system, during an inpatient psychiatric admission...
November 22, 2017: Sleep
https://www.readbyqxmd.com/read/29170501/idiopathic-rem-sleep-behaviour-disorder-and-neurodegeneration-an-update
#9
REVIEW
Birgit Högl, Ambra Stefani, Aleksandar Videnovic
So-called idiopathic rapid eye movement (REM) sleep behaviour disorder (RBD), formerly seen as a rare parasomnia, is now recognized as the prodromal stage of an α-synucleinopathy. Given the very high risk that patients with idiopathic RBD have of developing α-synucleinopathies, such as Parkinson disease (PD), PD dementia, dementia with Lewy bodies or multiple system atrophy, and the outstandingly high specificity and very long interval between the onset of idiopathic RBD and the clinical manifestations of α-synucleinopathies, the prodromal phase of this disorder represents a unique opportunity for potentially disease-modifying intervention...
November 24, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29170000/sleep-disorder-and-altered-locomotor-activity-as-biomarkers-of-the-parkinson-s-disease-cholinopathy-in-rat
#10
Jelena Ciric, Katarina Lazic, Slobodan Kapor, Milka Perovic, Jelena Petrovic, Vesna Pesic, Selma Kanazir, Jasna Saponjic
In order to find out the possible earliest biomarkers of Parkinson's disease (PD) cholinopathy, we followed the impact of bilateral pedunculopontine tegmental nucleus (PPT) lesion in rat on: the cortical and hippocampal sleep/wake states architectures, all sleep states related EEG microstructures, sleep spindles, the basal and stimulated locomotor activity. Sleep and basal locomotor activity in adult Wistar rats were followed during their inactive circadian phase, and throughout the same aging period. The bilateral PPT lesions were done by 0...
November 20, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/29162053/duloxetine-induced-rapid-eye-movement-sleep-behavior-disorder-a-case-report
#11
Lu Tan, Junying Zhou, Linghui Yang, Rong Ren, Ye Zhang, Taomei Li, Xiangdong Tang
BACKGROUND: Tricyclic antidepressants and selective serotonin reuptake inhibitors have been reported to induce the symptoms of rapid eye movement (REM) sleep behavior disorder (RBD) or to exacerbate REM sleep without atonia. With this case report, we found an association between typical RBD and duloxetine, a serotonin-noradrenaline reuptake inhibitor. CASE PRESENTATION: We present a case of a 62-year-old woman who experienced enactment behaviors with violent dreams that were associated with increased tonic or phasic chin electromyography activity during REM sleep after treated with duloxetine...
November 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/29161567/the-biology-of-rem-sleep
#12
REVIEW
John Peever, Patrick M Fuller
Considerable advances in our understanding of the mechanisms and functions of rapid-eye-movement (REM) sleep have occurred over the past decade. Much of this progress can be attributed to the development of new neuroscience tools that have enabled high-precision interrogation of brain circuitry linked with REM sleep control, in turn revealing how REM sleep mechanisms themselves impact processes such as sensorimotor function. This review is intended to update the general scientific community about the recent mechanistic, functional and conceptual developments in our current understanding of REM sleep biology and pathobiology...
November 20, 2017: Current Biology: CB
https://www.readbyqxmd.com/read/29156690/abnormal-amplitude-of-low-frequency-fluctuations-associated-with-rapid-eye-movement-in-chronic-primary-insomnia-patients
#13
Qian Ran, Jia Chen, Chuan Li, Li Wen, Faguo Yue, Tongsheng Shu, Jianxun Mi, Guangxian Wang, Lei Zhang, Dong Gao, Dong Zhang
Purpose: Chronic primary insomnia (CPI) is the most prevalent sleep disorder worldwide. CPI manifests as difficulties in sleep onset, maintaining sleep, prolonged sleep latency, and daytime impairment and is often accompanied by cognitive problems such as poor academic performance, poor attention, and decreased memory. The most popular explanation of insomnia is hyperarousal or increased activities of neurons. Rapid eye movement (REM) sleep detected by polysomnography (PSG) exhibits a positive relationship with brain homeostasis and can be helpful for optimally preparing an organism for emotional and social function...
October 17, 2017: Oncotarget
https://www.readbyqxmd.com/read/29145189/rem-sleep-behavior-disorder
#14
Claudio L Bassetti, Panagiotis Bargiotas
Rapid eye movement sleep behavior disorder (RBD) is a brain disorder, characterized by the dream enactment during rapid eye movement (REM) sleep due to a lack of physiologic muscle atonia and increased muscle twitching. Schenk was the first to describe this disorder in 1986; however, few authors reported in the 1970-1980s loss of physiological muscle atonia combined with dream enactment in the course of brainstem disorders and as a consequence of alcoholism and antidepressant treatment. RBD affects less than 1% of the adult population, but can be found in up to 25-50% of neurodegenerative disorders including Parkinson's disease, multisystem atrophy, and dementia with Lewy body...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29129579/epidemiology-of-rem-sleep-behavior-disorder-both-study-design-and-measurement-tool-count
#15
EDITORIAL
Jihui Zhang, Shirley Xin Li, Siu Ping Lam, Yun-Kwok Wing
No abstract text is available yet for this article.
September 29, 2017: Sleep Medicine
https://www.readbyqxmd.com/read/29117888/the-rem-sleep-behavior-disorder-screening-questionnaire-validation-study-of-the-korean-version-rbdq-kr
#16
Sooyeoun You, Hye-Jin Moon, So Young Do, Yun-Kwok Wing, Jun-Sang Sunwoo, Ki-Young Jung, Yong Won Cho
STUDY OBJECTIVES: REM sleep behavior disorder (RBD) is a parasomnia that is commonly associated with neurodegenerative disorders. We aimed to validate the Hong Kong version of the self-reported RBD questionnaire (RBDQ-HK) with the Korean version (RBDQ-KR) and to investigate its clinical usefulness. METHODS: One-hundred five patients with RBD and 105 age- and sex-matched controls were enrolled. Thirty were randomly selected for a retest with the questionnaire after 2 to 4 weeks without any treatment...
November 1, 2017: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
https://www.readbyqxmd.com/read/29112823/obstructive-sleep-apnea-during-rapid-eye-movement-sleep-and-cardiovascular-disease
#17
R Nisha Aurora, Ciprian Crainiceanu, Daniel J Gottlieb, Ji Soo Kim, Naresh M Punjabi
BACKGROUND: Obstructive sleep apnea (OSA) during rapid eye movement (REM) sleep is a common disorder. Data on whether OSA that occurs predominantly during REM sleep is associated with health outcomes are limited. The present study examined the association between OSA during REM sleep and a composite cardiovascular endpoint in a community sample with and without prevalent cardiovascular disease. METHODOLOGY: Full montage home polysomnography was conducted as part of the Sleep Heart Health Study...
November 7, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/29111021/differences-in-clinical-characteristics-when-rem-sleep-behavior-disorder-precedes-or-comes-after-the-onset-of-parkinson-s-disease
#18
Takashi Nomura, Masafumi Kishi, Kenji Nakashima
OBJECTIVE: Rapid eye movement (REM) sleep behavior disorder (RBD) is important not only as a preclinical symptom of Parkinson's disease (PD), but also as an aggravating symptom of PD. However, it is not known whether the onset of RBD in relation to PD affects the clinical characteristics of PD. A cross-sectional study comparing clinical characteristics of PD between patients with RBD occurring before and after the onset of PD was conducted. METHODS: Interviews regarding RBD symptoms were conducted and polysomnography was performed on 136 patients with PD...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29102236/rem-sleep-behavior-disorder-portends-poor-prognosis-in-parkinson-s-disease-a-systematic-review
#19
REVIEW
Yoon Kim, Young Eun Kim, Eun Ok Park, Chae Won Shin, Han-Joon Kim, Beomseok Jeon
REM sleep behavior disorder (RBD) is a parasomnia wherein a loss of REM sleep atonia manifests as dream-enactment, often violent. Aside from its significance as a predictor of PD, RBD in PD may imply more than merely screaming at night and experiencing sleep fragmentation. To probe its significance as a prognostic factor in PD, we performed a systematic literature review. Analysis of prospective studies reveals baseline RBD confers a higher risk of developing dementia and hallucinations. In cross-sectional studies, RBD is associated with the non-tremor predominant motor phenotype and autonomic dysfunction...
October 25, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/29101940/rem-sleep-behavior-disorder-diagnosis-clinical-implications-and-future-directions
#20
REVIEW
Erik K St Louis, Bradley F Boeve
Rapid eye movement sleep behavior disorder (RBD) is diagnosed by a clinical history of dream enactment accompanied by polysomnographic rapid eye movement sleep atonia loss (rapid eye movement sleep without atonia). Rapid eye movement sleep behavior disorder is strongly associated with neurodegenerative disease, especially synucleinopathies such as Parkinson disease, dementia with Lewy bodies, and multiple system atrophy. A history of RBD may begin several years to decades before onset of any clear daytime symptoms of motor, cognitive, or autonomic impairments, suggesting that RBD is the presenting manifestation of a neurodegenerative process...
November 2017: Mayo Clinic Proceedings
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