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https://www.readbyqxmd.com/read/28231463/neural-circuitry-of-wakefulness-and-sleep
#1
REVIEW
Thomas E Scammell, Elda Arrigoni, Jonathan O Lipton
Sleep remains one of the most mysterious yet ubiquitous animal behaviors. We review current perspectives on the neural systems that regulate sleep/wake states in mammals and the circadian mechanisms that control their timing. We also outline key models for the regulation of rapid eye movement (REM) sleep and non-REM sleep, how mutual inhibition between specific pathways gives rise to these distinct states, and how dysfunction in these circuits can give rise to sleep disorders.
February 22, 2017: Neuron
https://www.readbyqxmd.com/read/28228742/sleep-dependent-consolidation-of-rewarded-behavior-is-diminished-in-children-with-attention-deficit-hyperactivity-disorder-and-a-comorbid-disorder-of-social-behavior
#2
Christian D Wiesner, Ina Molzow, Alexander Prehn-Kristensen, Lioba Baving
Children suffering from attention-deficit hyperactivity disorder (ADHD) often also display impaired learning and memory. Previous research has documented aberrant reward processing in ADHD as well as impaired sleep-dependent consolidation of declarative memory. We investigated whether sleep also fosters the consolidation of behavior learned by probabilistic reward and whether ADHD patients with a comorbid disorder of social behavior show deficits in this memory domain, too. A group of 17 ADHD patients with comorbid disorders of social behavior aged 8-12 years and healthy controls matched for age, IQ, and handedness took part in the experiment...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28227264/sleep-architecture-measurement-based-on-cardiorespiratory-parameters
#3
Alexander Tataraidze, Lyudmila Korostovtseva, Lesya Anishchenko, Mikhail Bochkarev, Yurii Sviryaev, Alexander Tataraidze, Lyudmila Korostovtseva, Lesya Anishchenko, Mikhail Bochkarev, Yurii Sviryaev, Mikhail Bochkarev, Yurii Sviryaev, Lesya Anishchenko, Lyudmila Korostovtseva, Alexander Tataraidze
This paper presents a method for the detection of wakeful state, rapid eye movement sleep (REM), light sleep (N1&N2) and deep sleep (N3&N4) based on cardiorespiratory parameters. Experiments were conducted with data of 625 subjects without sleep-disordered breathing selected from the SHHS dataset. Compared to previous studies, our method considers results of neighboring epochs classification and epoch position over record time. The method demonstrates Cohen's kappa of 0.57 ± 0.13 and the accuracy of 71.4 ± 8...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227112/estimation-of-macro-sleep-stages-from-whole-night-audio-analysis
#4
E Dafna, M Halevi, D Ben Or, A Tarasiuk, Y Zigel, E Dafna, M Halevi, D Ben Or, A Tarasiuk, Y Zigel, D Ben Or, Y Zigel, M Halevi, E Dafna, A Tarasiuk
During routine sleep diagnostic procedure, sleep is broadly divided into three states: rapid eye movement (REM), non-REM (NREM) states, and wake, frequently named macro-sleep stages (MSS). In this study, we present a pioneering attempt for MSS detection using full night audio analysis. Our working hypothesis is that there might be differences in sound properties within each MSS due to breathing efforts (or snores) and body movements in bed. In this study, audio signals of 35 patients referred to a sleep laboratory were recorded and analyzed...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28227110/bioradiolocation-based-sleep-stage-classification
#5
Alexander Tataraidze, Lyudmila Korostovtseva, Lesya Anishchenko, Mikhail Bochkarev, Yurii Sviryaev, Sergey Ivashov, Alexander Tataraidze, Lyudmila Korostovtseva, Lesya Anishchenko, Mikhail Bochkarev, Yurii Sviryaev, Sergey Ivashov, Mikhail Bochkarev, Yurii Sviryaev, Lesya Anishchenko, Lyudmila Korostovtseva, Sergey Ivashov, Alexander Tataraidze
This paper presents a method for classifying wakefulness, REM, light and deep sleep based on the analysis of respiratory activity and body motions acquired by a bioradar. The method was validated using data of 32 subjects without sleep-disordered breathing, who underwent a polysomnography study in a sleep laboratory. We achieved Cohen's kappa of 0.49 in the wake-REM-light-deep sleep classification, 0.55 for the wake-REM-NREM classification and 0.57 for the sleep/wakefulness determination. The results might be useful for the development of unobtrusive sleep monitoring systems for diagnostics, prevention, and management of sleep disorders...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226697/differences-in-white-matter-microstructure-between-parkinson-s-disease-patients-with-and-without-rem-sleep-behavior-disorder
#6
Farzaneh Rahmani, Mina Ansari, Atefeh Pooyan, Mehdi M Mirbagheri, Mohammad Hadi Aarabi, Farzaneh Rahmani, Mina Ansari, Atefeh Pooyan, Mehdi M Mirbagheri, Mohammad Hadi Aarabi, Mehdi M Mirbagheri, Farzaneh Rahmani, Atefeh Pooyan, Mina Ansari, Mohammad Hadi Aarabi
REM sleep behavior disorder (RBD) is characterized by increased muscle tone and violent limb movements and usually occurs during the early stages of Parkinson disease (PD). PD patients with RBD represent faster motor progression and cognitive dysfunction. We used diffusion imaging to assess which regions are involved in this phenomenon. In the current study, we computed Quantitative Anisotropic (QA), which is based on spin distribution function (SDF) that quantifies the density of diffusing water and is more sensitive to psychological differences between groups and also diffusion MRI connectometry to conduct group analysis between age and gender matched PD patients with and without RBD...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28219749/behavioral-phenotypes-associated-with-mptp-induction-of-partial-lesions-in-common-marmosets-callithrix-jacchus
#7
Kimberley A Phillips, Corinna N Ross, Jennifer Spross, Catherine J Cheng, Alyssa Izquierdo, K C Biju, Cang Chen, Senlin Li, Suzette D Tardif
Parkinson's disease is a chronic neurodegenerative disorder with the core motor features of resting tremor, bradykinesia, rigidity, and postural instability. Non-motor symptoms also occur, and include cognitive dysfunction, mood disorders, anosmia (loss of smell), and REM sleep disturbances. As the development of medications and other therapies for treatment of non-motor symptoms is ongoing, it is essential to have animal models that aid in understanding the neural changes underlying non-motor PD symptoms and serve as a testing ground for potential therapeutics...
February 17, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28215911/conditions-associated-with-rem-sleep-behaviour-disorder-description-of-a-hospital-series
#8
M J Abenza Abildúa, A Miralles Martinez, F J Arpa Gutiérrez, V Lores Gutiérrez, C Algarra Lucas, C Jimeno Montero, B Sánchez García, M Mata Álvarez-Santullano, C Borrue Fernández, G Cordero Martín, G Gutiérrez Cueto, M D Torrecillas Narváez, I Thuissard Vasallo, A Gómez Aceña
INTRODUCTION: REM sleep behaviour disorder (RBD) is characterised by violent behaviours (screaming, kicking, vivid dreams) during REM sleep. It has a prevalence of 1% to 2% of the general population and is especially frequent in men and the population older than 60. In the last decade, RBD has been suggested to be a prodrome of neurodegenerative disease. We analysed associated neurological diseases and responses to drug treatment in 33 patients with RBD treated in the multidisciplinary sleep disorders unit at Hospital Infanta Sofía...
February 16, 2017: Neurología: Publicación Oficial de la Sociedad Española de Neurología
https://www.readbyqxmd.com/read/28215267/a-community-based-study-of-risk-factors-for-probable-rapid-eye-movement-sleep-behavior-disorder
#9
Jian-Fang Ma, Yuan Qiao, Xiang Gao, Liang Liang, Xiao-Li Liu, Dun-Hui Li, Hui-Dong Tang, Sheng-Di Chen
OBJECTIVES: To cross-sectionally explore the potential risk factors for rapid eye movement (REM) sleep behavior disorder (RBD) in a community cohort in Shanghai. METHODS: Based on the validated RBD screening questionnaire (RBDSQ), we identified individuals with probable RBD (pRBD) in 3635 community-dwelling residents (≥50 years old) from an urban community of Shanghai. Potential risk factors of pRBD, including age, sex, smoking, socioeconomic status, obesity, consumption of tea (surrogate for caffeine intake) and alcohol, medications and chronic disease status, were assessed via questionnaire...
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28215261/rem-sleep-behavior-disorder-causing-subdural-hematoma
#10
Oscar Ramos-Campoy, Carles Gaig, Monica Villas, Alex Iranzo, Joan Santamaria
No abstract text is available yet for this article.
February 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28211138/nocturnal-autonomic-nervous-system-activity-and-morning-proinflammatory-cytokines-in-young-adult-african-americans
#11
Kimberly A Bell, Ihori Kobayashi, Yuanxiu Chen, Thomas A Mellman
Compromised sleep and increased sympathetic nervous system (SNS) activity are implicated in the pathogenesis of, and disparities in, cardiovascular disease. Parasympathetic dominance during sleep may be important for cardiovascular health. Sleep and autonomic balance influence immune activity, which impacts atherogenesis. We evaluated relationships between autonomic balance during sleep and morning levels of the immune activating cytokines, C-reactive protein (CRP) and interleukin (IL)-6. Ninety-four (59 female) young adult African Americans without medical conditions and substance use disorders spent 2 consecutive nights in a clinical research unit for sleep recordings and blood drawing on awakening...
February 17, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28201721/diagnostic-value-of-isolated-mentalis-versus-mentalis-plus-upper-limb-electromyography-in-idiopathic-rem-sleep-behavior-disorder-patients-eventually-developing-a-neurodegenerative-syndrome
#12
Ana Fernández-Arcos, Alex Iranzo, Mónica Serradell, Carles Gaig, Marc Guaita, Manel Salamero, Joan Santamaria
No abstract text is available yet for this article.
February 13, 2017: Sleep
https://www.readbyqxmd.com/read/28186315/sleep-study-in-disruptive-mood-dysregulation-disorder-and-bipolar-children
#13
Xavier Estrada-Prat, Ion Álvarez-Guerrico, María J Bleda-Hernández, Ester Camprodon-Rosanas, Santiago Batlle-Vila, Elena Pujals-Altes, María T Nascimento-Osorio, Luís M Martín-López, Enric Álvarez-Martínez, Víctor Pérez-Solá, Soledad Romero-Cela
INTRODUCTION: Decreased need for sleep has been proposed as a core symptom of mania and it has been associated with the pathogenesis of Bipolar Disorder. The emergence of Disruptive Mood Dysregulation Disorder (DMDD) as a new diagnostic has been controversial and much has been speculated about its relationship with the bipolar spectrum. REM sleep fragmentation could be a biomarker of affective disorders and it would help us to differentiate them from other disorders. METHOD: Polysomnographic cross-sectional study of children with DMDD, bipolar disorder and Attention Deficit Hyperactivity Disorder (ADHD)...
January 2017: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/28180961/dermal-phospho-alpha-synuclein-deposits-confirm-rem-sleep-behaviour-disorder-as-prodromal-parkinson-s-disease
#14
Kathrin Doppler, Hanna-Maria Jentschke, Lena Schulmeyer, David Vadasz, Annette Janzen, Markus Luster, Helmut Höffken, Geert Mayer, Joachim Brumberg, Jan Booij, Thomas Musacchio, Stephan Klebe, Elisabeth Sittig-Wiegand, Jens Volkmann, Claudia Sommer, Wolfgang H Oertel
Phosphorylated alpha-synuclein (p-alpha-syn) deposits, one of the neuropathological hallmarks of Parkinson's disease (PD), have recently been detected in dermal nerve fibres in PD patients with good specificity and sensitivity. Here, we studied whether p-alpha-syn may serve as a biomarker in patients with a high risk of developing PD, such as those with REM sleep behaviour disorder (RBD). We compared the presence and distribution of p-alpha-syn deposits in dermal nerve fibres in 18 patients with RBD, 25 patients with early PD and 20 normal controls...
February 8, 2017: Acta Neuropathologica
https://www.readbyqxmd.com/read/28173973/personality-and-addictive-behaviours-in-early-parkinson-s-disease-and-rem-sleep-behaviour-disorder
#15
Fahd Baig, Michael A Lawton, Michal Rolinski, Claudio Ruffmann, Johannes C Klein, Kannan Nithi, David Okai, Yoav Ben-Shlomo, Michele T M Hu
INTRODUCTION: Changes in personality have been described in Parkinson's disease (PD), with suggestion that those with established disease tend to be risk averse with a disinclination for addictive behaviour. However, little is known about the earliest and prodromal stages. Personality and its relationship with addictive behaviours can help answer important questions about the mechanisms underlying PD and addiction. METHODS: 941 population-ascertained PD subjects within 3...
February 1, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28163603/rem-sleep-behavior-disorder-rbd-update-on-diagnosis-and-treatment
#16
Birgit Högl, Ambra Stefani
BACKGROUND: REM sleep behavior disorder (RBD) is parasomnia characterized by dream enactment and enabled by disruption of physiological muscle atonia during REM sleep. Over the past few years, diagnostic criteria and the methods used to confirm diagnosis have been updated. OBJECTIVE: In this review article, the current knowledge regarding RBD diagnosis and treatment is presented. METHODS: A selective literature search was carried out. RESULTS AND DISCUSSION: Although several RBD screening questionnaires have been developed, diagnosis can only be definitely confirmed on the basis of polysomnography...
2017: Somnologie: Schlafforschung und Schlafmedizin, Somnology: Sleep Research and Sleep Medicine
https://www.readbyqxmd.com/read/28161453/rhythms-dysregulation-a-new-perspective-for-understanding-ptsd
#17
Jacques Dayan, Géraldine Rauchs, Bérengère Guillery-Girard
Post-traumatic stress disorder (PTSD) is a complex syndrome that may occur after exposure to one or more traumatic events. It associates physiological, emotional, and cognitive changes Brain and hormonal modifications contribute to some impairments in learning, memory, and emotion regulation. Some of these biological dysfunctions may be analyzed in terms of rhythms dysregulation that would be expressed through endocrine rhythmicity, sleep organization, and temporal synchrony in brain activity. In the first part of this article, we report studies on endocrine rhythmicity revealing that some rhythms abnormalities are frequently observed, although not constantly, for both cortisol and sympathetic nervous system (SNS) activity...
February 1, 2017: Journal of Physiology, Paris
https://www.readbyqxmd.com/read/28160778/meta-analysis-on-the-prevalence-of-rem-sleep-behavior-disorder-symptoms-in-parkinson-s-disease
#18
Jia Zhang, Chuan-Ying Xu, Jun Liu
BACKGROUND: Our study was aimed to evaluate the risk of a selected non-motor symptom, namely rapid eye movement behavior disorder (RBD) symptoms, among patients with newly diagnosed Parkinson disease compared with health controls. METHODS: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for meta-analysis and Cochrane manual were followed. Studies on RBD symptoms and PD were searched using PubMed, Embase, Web of Science and Cochrane library databases...
February 4, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28137954/a-novel-animal-model-offers-deeper-insights-into-rem-sleep-behaviour-disorder
#19
Carlos H Schenck, Mark W Mahowald
No abstract text is available yet for this article.
February 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28132976/diagnosis-disease-notification-and-management-of-rapid-eye-movement-rem-sleep-behavior-disorder
#20
Takayoshi Shimohata, Yuichi Inoue, Koichi Hirata
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by dream enactment behavior during REM sleep. It has been demonstrated that patients with idiopathic RBD are at a significantly increased risk of developing one of the α-synucleinopathies later in life, and this is called "phenoconversion". Although some physicians argue against disclosing information that could cause patients psychological stress, the patients also have a "right to know" about their own disease. Therefore, determining when and how to disclose this information, in addition to appropriate follow-up, is important...
January 28, 2017: Rinshō Shinkeigaku, Clinical Neurology
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