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"early rheumatoid arthritis"

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https://www.readbyqxmd.com/read/28511291/fatigue-older-age-higher-body-mass-index-and-female-gender-predict-worse-disability-in-early-rheumatoid-arthritis-despite-treatment-to-target-a-comparison-of-two-observational-cohort-studies-from-the-united-kingdom
#1
Sarah Twigg, Elizabeth M A Hensor, Jane Freeston, Ai Lyn Tan, Paul Emery, Alan Tennant, Ann W Morgan
OBJECTIVES: Compare disease activity and disability over 2 years in early rheumatoid arthritis (RA) before and after implementation of treat to target (T2T) and identify predictors of adverse outcome. METHODS: Yorkshire Early Arthritis Register (YEAR) recruited 725 patients with early RA between 2002-2009, treated with a step-up approach. The IACON study (Inflammatory Arthritis CONtinuum) recruited cases between 2010-2014 and treated to target. 384 IACON cases met 2010 ACR/EULAR criteria...
May 16, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28510734/predictors-of-and-outcomes-following-orthopaedic-joint-surgery-in-patients-with-early-rheumatoid-arthritis-followed-for-20-years
#2
James M Gwinnutt, Deborah P M Symmons, Alexander J MacGregor, Jacqueline R Chipping, Chloe Lapraik, Tarnya Marshall, Mark Lunt, Suzanne M M Verstappen
Objectives.: To analyse predictors and outcomes of major orthopaedic surgery in a cohort of RA patients followed for 20 years. Methods.: Patients were recruited to the Norfolk Arthritis Register from 1990 to 1994. Demographic and clinical variables (including the HAQ and swollen and tender joint counts) were assessed at baseline; the 2010 ACR/EULAR RA classification criteria were applied. Patients reported incident comorbidities and major orthopaedic joint surgery (replacement, synovectomy, fusion, excision) when reassessed at years 1, 2, 3, 5, 7, 10, 15 and 20...
May 16, 2017: Rheumatology
https://www.readbyqxmd.com/read/28509333/altered-glycan-accessibility-on-native-immunoglobulin-g-complexes-in-early-rheumatoid-arthritis-and-its-changes-during-therapy
#3
Judith Stümer, Mona H C Biermann, Jasmin Knopf, Iryna Magorivska, Alf Kastbom, Anna Svärd, Christina Janko, Rostyslav Bilyy, Georg Schett, Christopher Sjöwall, Martin Herrmann, Luis E Muñoz
The goal of this study was to investigate the glycosylation profile of native IgG present in serum immune complexes in patients with rheumatoid arthritis (RA). To accomplish this, lectin binding assays, detecting the accessibility of glycans present on IgG-containing immune complexes by biotinylated lectins were employed. Lectins capturing fucosyl residues (AAL), fucosylated tri-mannose N-glycan core sites (LCA), terminal sialic acid residues (SNA) and O-glycosidically-linked galactose/N-acetylgalactosamine (GalNac-L) were used...
May 16, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28482738/hepcidin-plasma-levels-are-not-associated-with-changes-in-haemoglobin-in-early-rheumatoid-arthritis-patients
#4
R D Østgård, H Glerup, A G Jurik, T W Kragstrup, K Stengaard-Pedersen, M L Hetland, K Hørslev-Petersen, P Junker, B W Deleuran
OBJECTIVE: A reduction in haemoglobin level is a frequent complication among rheumatoid arthritis (RA) patients. Hepcidin has been linked to disturbed erythropoiesis. The objective of this study was to investigate the longitudinal changes in hepcidin in patients with early RA. METHOD: Hepcidin plasma concentrations were measured by enzyme-linked immunosorbent assay in patients with early RA (n = 80) and healthy volunteers (HV, n = 40). Haemoglobin and other iron-related proteins were also measured...
May 9, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28464477/smoking-behavior-changes-in-the-early-rheumatoid-arthritis-period-and-risk-of-mortality-during-36-years-of-prospective-follow-up
#5
Jeffrey A Sparks, Shun-Chiao Chang, Uyen-Sa D T Nguyen, Medha Barbhaiya, Sara K Tedeschi, Bing Lu, Karen H Costenbader, Yuqing Zhang, Hyon K Choi, Elizabeth W Karlson
OBJECTIVE: We investigated whether rheumatoid arthritis (RA) diagnosis influences smoking behavior changes and whether these changes were associated with mortality. METHODS: We identified an incident RA cohort in the Nurses' Health Study (NHS, 1976-2012). Behavioral data were collected through biennial questionnaires. We created a comparison cohort, matching RA cases to women without RA by age and calendar year at the index date of RA diagnosis. To investigate smoking behavior changes in the early RA period, sustained cessation was defined as permanently quitting within four years of RA/index date...
May 2, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28460018/evaluation-of-the-diagnostic-accuracy-of-hand-and-foot-mri-for-early-rheumatoid-arthritis
#6
Wouter P Nieuwenhuis, Hanna W van Steenbergen, Lukas Mangnus, Elize C Newsum, Johan L Bloem, Tom W J Huizinga, Saskia le Cessie, Monique Reijnierse, Annette H M van der Helm-van Mil
Objectives.: To assess the diagnostic value of MRI for early RA. In some RA patients, a classifiable diagnosis cannot be made at first presentation; these patients present with unclassified arthritis (UA). The use of MRI for early diagnosis of RA is recommended, yet the evidence for its reliability is limited. Methods.: MRI of hand and foot was performed in 589 early arthritis patients included in the Leiden Early Arthritis Clinic (229 presented with RA, 159 with other arthritides and 201 with UA)...
April 27, 2017: Rheumatology
https://www.readbyqxmd.com/read/28450312/long-term-outcome-is-better-when-a-methotrexate-based-treatment-strategy-is-combined-with-10-mg-prednisone-daily-follow-up-after-the-second-computer-assisted-management-in-early-rheumatoid-arthritis-trial
#7
Mary Safy, Jwg Jacobs, N D IJff, Jwj Bijlsma, J M van Laar, Mjh deHair
OBJECTIVES: In the second Computer-Assisted Management in Early Rheumatoid Arthritis trial, patients had started with methotrexate and 10 mg prednisone (MTX+pred) or placebo (MTX+plac). After the trial, prednisone was tapered and stopped, if possible. The objective was to compare, during the post-trial follow-up between the two former strategy groups, initiation of the first biological disease-modifying antirheumatic drug (bDMARD), radiographic outcome and onset of glucocorticoid (GC)-related comorbidities...
April 27, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28440350/high-frequency-ultrasonography-of-the-hand-versus-anti-ra33-evaluation-in-early-rheumatoid-arthritis-a-pilot-study
#8
Andreea Lili Barbulescu, Paulina Lucia Ciurea, Carmen Mitran, Beatrice Andreea Chisalau, Cristina Dorina Parvanescu, Sineta Cristina Firulescu, Maria Balasoiu, Mihail Virgil Boldeanu, Horatiu Popoviciu, Florentin Ananu Vreju
AIM: Accurate diagnosis and early treatment in rheumatoid arthritis (RA) can lead to a good outcome and a correct management of the disease. We aimed toinvestigate the prognostic value of anti-RA33 antibodies, by evaluating the relationship with ultrasonographic (US) findings in patients with early RA. MATERIAL AND METHODS: We performed a prospective study which included 29 patients, diagnosed with early RA according to the ACR/EULAR 2010 criteria and 21 sex and age-matched control subjects...
April 22, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28439423/rheumatoid-arthritis-what-do-mri-and-ultrasound-show
#9
EDITORIAL
Iwona Sudoł-Szopińska, Lennart Jans, James Teh
Rheumatoid arthritis is the most common inflammatory arthritis, affecting approximately 1% of the world's population. Its pathogenesis has not been completely understood. However, there is evidence that the disease may involve synovial joints, subchondral bone marrow as well as intra- and extraarticular fat tissue, and may lead to progressive joint destruction and disability. Over the last two decades, significant improvement in its prognosis has been achieved owing to new strategies for disease management, the emergence of new biologic therapies and better utilization of conventional disease-modifying antirheumatic drugs...
March 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28408733/high-performance-liquid-chromatography-hplc-quantification-of-liposome-delivered-doxorubicin-in-arthritic-joints-of-collagen-induced-arthritis-rats
#10
Hongqing Niu, Menghua Xu, Shuangtian Li, Junwei Chen, Jing Luo, Xiangcong Zhao, Chong Gao, Xiaofeng Li
BACKGROUND Neoangiogenesis occurring in inflamed articular synovium in early rheumatoid arthritis (RA) is characterized by enhanced vascular permeability that allows nanoparticle agents, including liposomes, to deliver encapsulated drugs to arthritic joints and subsequently improve therapeutic efficacy and reduce adverse effects. However, the targeting distribution of liposomes in arthritic joints during RA has not been quantitatively demonstrated. We performed this study to evaluate the targeting distribution of PEGylated doxorubicin liposomes in the arthritic joints of collagen-induced arthritis (CIA) rats by high-performance liquid chromatography (HPLC)...
April 14, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28399940/baseline-jak-phosphorylation-profile-of-peripheral-blood-leukocytes-studied-by-whole-blood-phosphospecific-flow-cytometry-is-associated-with-1-year-treatment-response-in-early-rheumatoid-arthritis
#11
Krista Kuuliala, Antti Kuuliala, Riitta Koivuniemi, Hannu Kautiainen, Heikki Repo, Marjatta Leirisalo-Repo
BACKGROUND: We found recently that baseline signal transducer and activator of transcription 3 phosphorylation in peripheral blood CD4(+) T cells of patients with early rheumatoid arthritis (RA) is associated with treatment response to synthetic disease-modifying antirheumatic drugs (DMARDs). This prompted us to study the baseline phosphorylation profiles of Janus kinases (JAKs) in blood leukocytes with respect to treatment response in early RA. METHODS: Thirty-five DMARD-naïve patients with early RA provided blood samples for whole blood flow cytometric determination of phosphorylation of JAKs in CD4(+) and CD8(+) T cells, CD19(+) B cells, and CD14(+) monocytes...
April 11, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28389552/tocilizumab-combination-therapy-or-monotherapy-or-methotrexate-monotherapy-in-methotrexate-naive-patients-with-early-rheumatoid-arthritis-2-year-clinical-and-radiographic-results-from-the-randomised-placebo-controlled-function-trial
#12
Gerd R Burmester, William F Rigby, Ronald F van Vollenhoven, Jonathan Kay, Andrea Rubbert-Roth, Ricardo Blanco, Alysha Kadva, Sophie Dimonaco
OBJECTIVE: Investigate whether the efficacy and safety of intravenous tocilizumab (TCZ) demonstrated at week 52 in patients with early rheumatoid arthritis (RA) are maintained to week 104. METHODS: Methotrexate (MTX)-naive patients with early progressive RA were randomly assigned to double-blind 4 mg/kg TCZ+MTX, 8 mg/kg TCZ+MTX, 8 mg/kg TCZ+placebo or placebo+MTX for 104 weeks. Patients not receiving 8 mg/kg TCZ and not achieving Disease Activity Score-28 joints (DAS28-erythrocyte sedimentation rate (ESR)) ≤3...
April 7, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28379495/the-effect-on-treatment-response-of-fibromyalgic-symptoms-in-early-rheumatoid-arthritis-patients-results-from-the-espoir-cohort
#13
Josefina Durán, Bernard Combe, Jingbo Niu, Nathalie Rincheval, Cécile Gaujoux-Viala, David T Felson
No abstract text is available yet for this article.
April 3, 2017: Rheumatology
https://www.readbyqxmd.com/read/28371257/dietary-intake-of-polyunsaturated-fatty-acids-and-pain-in-spite-of-inflammatory-control-among-methotrexate-treated-early-rheumatoid-arthritis-patients
#14
Cecilia Lourdudoss, Daniela Di Giuseppe, Alicja Wolk, Helga Westerlind, Lars Klareskog, Lars Alfredsson, Ronald F van Vollenhoven, Jon Lampa
Objective To investigate potential associations between dietary intake of polyunsaturated fatty acids (PUFA) and pain patterns in early rheumatoid arthritis (RA) patients after three months of methotrexate (MTX) treatment. Methods We included 591 early RA patients with MTX monotherapy from a population based prospective case-control study, the Epidemiological Investigation of Rheumatoid Arthritis (EIRA). Dietary data on PUFA (food frequency questionnaires) were linked with data on unacceptable pain (visual analogue scale (VAS) >40mm), non-inflammatory/refractory pain (VAS >40mm and C-reactive protein (CRP) <10mg/L) and inflammatory pain (VAS >40mm and CRP >10mg/L) after three months...
March 28, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28367663/three-out-of-four-disease-modifying-anti-rheumatic-drug-na%C3%A3-ve-rheumatoid-arthritis-patients-meet-28-joint-disease-activity-score-remission-at-12%C3%A2-months-results-from-the-fin-era-cohort
#15
T Rannio, J Asikainen, P Hannonen, T Yli-Kerttula, P Ekman, L Pirilä, L Kuusalo, M Mali, M Puurtinen-Vilkki, S Kortelainen, J Paltta, K Taimen, M Kauppi, K Laiho, S Nyrhinen, H Mäkinen, P Isomäki, T Uotila, K Aaltonen, H Kautiainen, T Sokka
OBJECTIVE: To assess what proportion of patients with disease-modifying anti-rheumatic drug (DMARD)-naïve early rheumatoid arthritis (ERA) reach 28-joint Disease Activity Score (DAS28) remission over 1 year, and remission variability across clinics in Finland. METHOD: Patients with DMARD-naïve newly diagnosed inflammatory arthritis were recruited. The proportion of patients in 28-joint Disease Activity Score with three variables (DAS28-3) remission was compared across sites...
April 3, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28365578/patients-with-early-rheumatoid-arthritis-in-the-2000s-have-equal-disability-and-pain-despite-less-disease-activity-compared-with-the-1990s-data-from-the-barfot-study-over-8-years
#16
Maria L E Andersson, Kristina Forslind, Ingiäld Hafström
OBJECTIVE: To compare outcomes over the first 8 years in patients with early rheumatoid arthritis (RA) recruited in the 1990s and the 2000s, with a special focus on functional disability and its possible predictors. METHODS: Data were acquired from 1938 patients with early RA (American College of Rheumatology 1987 criteria) included in the BARFOT study, who had completed the 8-year followup. The patients were divided into 2 cohorts: cohort 1 (n = 928, 68% women) included from 1992 to 1999 and cohort 2 (n = 1010, 70% women) included from 2000 to 2006...
April 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28339365/thresholds-for-the-28-joint-disease-activity-score-das28-using-c-reactive-protein-are-lower-compared-to-das28-using-erythrocyte-sedimentation-rate-in-early-rheumatoid-arthritis
#17
Bindee Kuriya, Orit Schieir, Daming Lin, Juan Xiong, Janet Pope, Gilles Boire, Boulos Haraoui, John Carter Thorne, Diane Tin, Carol Hitchon, Shahin Jamal, Edward Keystone, Vivien P Bykerk
OBJECTIVES: The 28-Joint Disease Activity Score (DAS28) using C-reactive protein (CRP) and DAS28 using erythrocyte sedimentation rate (DAS28-ESR) may not be interchangeable. We sought to compare and estimate optimal thresholds for the DA28-CRP for use in early rheumatoid arthritis (ERA). METHODS: Patients from the Canadian Early Arthritis Cohort with baseline and 12 months' data for both DAS28-ESR and DAS28-CRP were examined for correlations and differences between DAS28-CRP and DAS28-ESR across their range of values...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28289873/patient-reported-outcomes-as-predictors-of-remission-in-early-rheumatoid-arthritis-patients-treated-with-tight-control-treat-to-target-approach
#18
Laura Kuusalo, Kari Puolakka, Hannu Kautiainen, Anna Karjalainen, Timo Malmi, Timo Yli-Kerttula, Marjatta Leirisalo-Repo, Vappu Rantalaiho
Identifying prognostic factors for remission in early rheumatoid arthritis (ERA) patients is of key clinical importance. We studied patient-reported outcomes (PROs) as predictors of remission in a clinical trial. We randomized 99 untreated ERA patients to receive remission-targeted treatment with three disease-modifying antirheumatic drugs and prednisolone for 24 months, and infliximab or placebo for the initial 6 months. At baseline, we measured following PROs: eight Short Form 36 questionnaire (SF-36) dimensions, patient's global assessment [PGA, visual analogue scale (VAS)], Health Assessment Questionnaire (HAQ), and pain VAS...
May 2017: Rheumatology International
https://www.readbyqxmd.com/read/28288682/low-disease-activity-for-up-to-3%C3%A2-years-after-adalimumab-discontinuation-in-patients-with-early-rheumatoid-arthritis-2-year-results-of-the-hopeful-3-study
#19
Yoshiya Tanaka, Hisashi Yamanaka, Naoki Ishiguro, Nobuyuki Miyasaka, Katsuyoshi Kawana, Junko Kimura, Naoki Agata, Tsutomu Takeuchi
BACKGROUND: This study was conducted to evaluate the feasibility of long-term adalimumab (ADA) discontinuation after achievement of low disease activity (LDA) in Japanese patients with early rheumatoid arthritis (RA) and to identify predictors of LDA maintenance. METHODS: In the HOPEFUL-1 study, patients received initial therapy with either ADA plus methotrexate (MTX; intensive therapy) or MTX alone (standard therapy) for 26 weeks, followed by ADA + MTX for 26 weeks...
March 14, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28282363/the-relationship-between-mental-health-disease-severity-and-genetic-risk-for-depression-in-early-rheumatoid-arthritis
#20
Jack Euesden, Faith Matcham, Matthew Hotopf, Sophia Steer, Andrew P Cope, Cathryn M Lewis, Ian C Scott
OBJECTIVE: Reduced mental health is prevalent in rheumatoid arthritis (RA). Although longitudinal studies are limited, there is evidence that depression associates with worse disease outcomes. We evaluated reciprocal relationships between mental health, RA severity and genetic risks for depression over 2-years in a well-characterised cohort of RA patients. METHODS: We evaluated 520 early RA patients previously enrolled to two clinical trials. Mental health was measured using the SF-36 mental health (MH) domain and mental component summary scores (MCS)...
March 9, 2017: Psychosomatic Medicine
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