keyword
MENU ▼
Read by QxMD icon Read
search

"early rheumatoid arthritis"

keyword
https://www.readbyqxmd.com/read/28440350/high-frequency-ultrasonography-of-the-hand-versus-anti-ra33-evaluation-in-early-rheumatoid-arthritis-a-pilot-study
#1
Andreea Lili Barbulescu, Paulina Lucia Ciurea, Carmen Mitran, Beatrice Andreea Chisalau, Cristina Dorina Parvanescu, Sineta Cristina Firulescu, Maria Balasoiu, Mihail Virgil Boldeanu, Horatiu Popoviciu, Florentin Ananu Vreju
AIM: Accurate diagnosis and early treatment in rheumatoid arthritis (RA) can lead to a good outcome and a correct management of the disease. We aimed toinvestigate the prognostic value of anti-RA33 antibodies, by evaluating the relationship with ultrasonographic (US) findings in patients with early RA. MATERIAL AND METHODS: We performed a prospective study which included 29 patients, diagnosed with early RA according to the ACR/EULAR 2010 criteria and 21 sex and age-matched control subjects...
April 22, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28439423/rheumatoid-arthritis-what-do-mri-and-ultrasound-show
#2
EDITORIAL
Iwona Sudoł-Szopińska, Lennart Jans, James Teh
Rheumatoid arthritis is the most common inflammatory arthritis, affecting approximately 1% of the world's population. Its pathogenesis has not been completely understood. However, there is evidence that the disease may involve synovial joints, subchondral bone marrow as well as intra- and extraarticular fat tissue, and may lead to progressive joint destruction and disability. Over the last two decades, significant improvement in its prognosis has been achieved owing to new strategies for disease management, the emergence of new biologic therapies and better utilization of conventional disease-modifying antirheumatic drugs...
March 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28408733/high-performance-liquid-chromatography-hplc-quantification-of-liposome-delivered-doxorubicin-in-arthritic-joints-of-collagen-induced-arthritis-rats
#3
Hongqing Niu, Menghua Xu, Shuangtian Li, Junwei Chen, Jing Luo, Xiangcong Zhao, Chong Gao, Xiaofeng Li
BACKGROUND Neoangiogenesis occurring in inflamed articular synovium in early rheumatoid arthritis (RA) is characterized by enhanced vascular permeability that allows nanoparticle agents, including liposomes, to deliver encapsulated drugs to arthritic joints and subsequently improve therapeutic efficacy and reduce adverse effects. However, the targeting distribution of liposomes in arthritic joints during RA has not been quantitatively demonstrated. We performed this study to evaluate the targeting distribution of PEGylated doxorubicin liposomes in the arthritic joints of collagen-induced arthritis (CIA) rats by high-performance liquid chromatography (HPLC)...
April 14, 2017: Medical Science Monitor Basic Research
https://www.readbyqxmd.com/read/28399940/baseline-jak-phosphorylation-profile-of-peripheral-blood-leukocytes-studied-by-whole-blood-phosphospecific-flow-cytometry-is-associated-with-1-year-treatment-response-in-early-rheumatoid-arthritis
#4
Krista Kuuliala, Antti Kuuliala, Riitta Koivuniemi, Hannu Kautiainen, Heikki Repo, Marjatta Leirisalo-Repo
BACKGROUND: We found recently that baseline signal transducer and activator of transcription 3 phosphorylation in peripheral blood CD4(+) T cells of patients with early rheumatoid arthritis (RA) is associated with treatment response to synthetic disease-modifying antirheumatic drugs (DMARDs). This prompted us to study the baseline phosphorylation profiles of Janus kinases (JAKs) in blood leukocytes with respect to treatment response in early RA. METHODS: Thirty-five DMARD-naïve patients with early RA provided blood samples for whole blood flow cytometric determination of phosphorylation of JAKs in CD4(+) and CD8(+) T cells, CD19(+) B cells, and CD14(+) monocytes...
April 11, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28389552/tocilizumab-combination-therapy-or-monotherapy-or-methotrexate-monotherapy-in-methotrexate-naive-patients-with-early-rheumatoid-arthritis-2-year-clinical-and-radiographic-results-from-the-randomised-placebo-controlled-function-trial
#5
Gerd R Burmester, William F Rigby, Ronald F van Vollenhoven, Jonathan Kay, Andrea Rubbert-Roth, Ricardo Blanco, Alysha Kadva, Sophie Dimonaco
OBJECTIVE: Investigate whether the efficacy and safety of intravenous tocilizumab (TCZ) demonstrated at week 52 in patients with early rheumatoid arthritis (RA) are maintained to week 104. METHODS: Methotrexate (MTX)-naive patients with early progressive RA were randomly assigned to double-blind 4 mg/kg TCZ+MTX, 8 mg/kg TCZ+MTX, 8 mg/kg TCZ+placebo or placebo+MTX for 104 weeks. Patients not receiving 8 mg/kg TCZ and not achieving Disease Activity Score-28 joints (DAS28-erythrocyte sedimentation rate (ESR)) ≤3...
April 7, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28379495/the-effect-on-treatment-response-of-fibromyalgic-symptoms-in-early-rheumatoid-arthritis-patients-results-from-the-espoir-cohort
#6
Josefina Durán, Bernard Combe, Jingbo Niu, Nathalie Rincheval, Cécile Gaujoux-Viala, David T Felson
No abstract text is available yet for this article.
April 3, 2017: Rheumatology
https://www.readbyqxmd.com/read/28371257/dietary-intake-of-polyunsaturated-fatty-acids-and-pain-in-spite-of-inflammatory-control-among-methotrexate-treated-early-rheumatoid-arthritis-patients
#7
Cecilia Lourdudoss, Daniela Di Giuseppe, Alicja Wolk, Helga Westerlind, Lars Klareskog, Lars Alfredsson, Ronald F van Vollenhoven, Jon Lampa
Objective To investigate potential associations between dietary intake of polyunsaturated fatty acids (PUFA) and pain patterns in early rheumatoid arthritis (RA) patients after three months of methotrexate (MTX) treatment. Methods We included 591 early RA patients with MTX monotherapy from a population based prospective case-control study, the Epidemiological Investigation of Rheumatoid Arthritis (EIRA). Dietary data on PUFA (food frequency questionnaires) were linked with data on unacceptable pain (visual analogue scale (VAS) >40mm), non-inflammatory/refractory pain (VAS >40mm and C-reactive protein (CRP) <10mg/L) and inflammatory pain (VAS >40mm and CRP >10mg/L) after three months...
March 28, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28367663/three-out-of-four-disease-modifying-anti-rheumatic-drug-na%C3%A3-ve-rheumatoid-arthritis-patients-meet-28-joint-disease-activity-score-remission-at-12%C3%A2-months-results-from-the-fin-era-cohort
#8
T Rannio, J Asikainen, P Hannonen, T Yli-Kerttula, P Ekman, L Pirilä, L Kuusalo, M Mali, M Puurtinen-Vilkki, S Kortelainen, J Paltta, K Taimen, M Kauppi, K Laiho, S Nyrhinen, H Mäkinen, P Isomäki, T Uotila, K Aaltonen, H Kautiainen, T Sokka
OBJECTIVE: To assess what proportion of patients with disease-modifying anti-rheumatic drug (DMARD)-naïve early rheumatoid arthritis (ERA) reach 28-joint Disease Activity Score (DAS28) remission over 1 year, and remission variability across clinics in Finland. METHOD: Patients with DMARD-naïve newly diagnosed inflammatory arthritis were recruited. The proportion of patients in 28-joint Disease Activity Score with three variables (DAS28-3) remission was compared across sites...
April 3, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28365578/patients-with-early-rheumatoid-arthritis-in-the-2000s-have-equal-disability-and-pain-despite-less-disease-activity-compared-with-the-1990s-data-from-the-barfot-study-over-8-years
#9
Maria L E Andersson, Kristina Forslind, Ingiäld Hafström
OBJECTIVE: To compare outcomes over the first 8 years in patients with early rheumatoid arthritis (RA) recruited in the 1990s and the 2000s, with a special focus on functional disability and its possible predictors. METHODS: Data were acquired from 1938 patients with early RA (American College of Rheumatology 1987 criteria) included in the BARFOT study, who had completed the 8-year followup. The patients were divided into 2 cohorts: cohort 1 (n = 928, 68% women) included from 1992 to 1999 and cohort 2 (n = 1010, 70% women) included from 2000 to 2006...
April 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/28339365/thresholds-for-the-28-joint-disease-activity-score-das28-using-c-reactive-protein-are-lower-compared-to-das28-using-erythrocyte-sedimentation-rate-in-early-rheumatoid-arthritis
#10
Bindee Kuriya, Orit Schieir, Daming Lin, Juan Xiong, Janet Pope, Gilles Boire, Boulos Haraoui, John Carter Thorne, Diane Tin, Carol Hitchon, Shahin Jamal, Edward Keystone, Vivien P Bykerk
OBJECTIVES: The 28-Joint Disease Activity Score (DAS28) using C-reactive protein (CRP) and DAS28 using erythrocyte sedimentation rate (DAS28-ESR) may not be interchangeable. We sought to compare and estimate optimal thresholds for the DA28-CRP for use in early rheumatoid arthritis (ERA). METHODS: Patients from the Canadian Early Arthritis Cohort with baseline and 12 months' data for both DAS28-ESR and DAS28-CRP were examined for correlations and differences between DAS28-CRP and DAS28-ESR across their range of values...
March 23, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28289873/patient-reported-outcomes-as-predictors-of-remission-in-early-rheumatoid-arthritis-patients-treated-with-tight-control-treat-to-target-approach
#11
Laura Kuusalo, Kari Puolakka, Hannu Kautiainen, Anna Karjalainen, Timo Malmi, Timo Yli-Kerttula, Marjatta Leirisalo-Repo, Vappu Rantalaiho
Identifying prognostic factors for remission in early rheumatoid arthritis (ERA) patients is of key clinical importance. We studied patient-reported outcomes (PROs) as predictors of remission in a clinical trial. We randomized 99 untreated ERA patients to receive remission-targeted treatment with three disease-modifying antirheumatic drugs and prednisolone for 24 months, and infliximab or placebo for the initial 6 months. At baseline, we measured following PROs: eight Short Form 36 questionnaire (SF-36) dimensions, patient's global assessment [PGA, visual analogue scale (VAS)], Health Assessment Questionnaire (HAQ), and pain VAS...
May 2017: Rheumatology International
https://www.readbyqxmd.com/read/28288682/low-disease-activity-for-up-to-3%C3%A2-years-after-adalimumab-discontinuation-in-patients-with-early-rheumatoid-arthritis-2-year-results-of-the-hopeful-3-study
#12
Yoshiya Tanaka, Hisashi Yamanaka, Naoki Ishiguro, Nobuyuki Miyasaka, Katsuyoshi Kawana, Junko Kimura, Naoki Agata, Tsutomu Takeuchi
BACKGROUND: This study was conducted to evaluate the feasibility of long-term adalimumab (ADA) discontinuation after achievement of low disease activity (LDA) in Japanese patients with early rheumatoid arthritis (RA) and to identify predictors of LDA maintenance. METHODS: In the HOPEFUL-1 study, patients received initial therapy with either ADA plus methotrexate (MTX; intensive therapy) or MTX alone (standard therapy) for 26 weeks, followed by ADA + MTX for 26 weeks...
March 14, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28282363/the-relationship-between-mental-health-disease-severity-and-genetic-risk-for-depression-in-early-rheumatoid-arthritis
#13
Jack Euesden, Faith Matcham, Matthew Hotopf, Sophia Steer, Andrew P Cope, Cathryn M Lewis, Ian C Scott
OBJECTIVE: Reduced mental health is prevalent in rheumatoid arthritis (RA). Although longitudinal studies are limited, there is evidence that depression associates with worse disease outcomes. We evaluated reciprocal relationships between mental health, RA severity and genetic risks for depression over 2-years in a well-characterised cohort of RA patients. METHODS: We evaluated 520 early RA patients previously enrolled to two clinical trials. Mental health was measured using the SF-36 mental health (MH) domain and mental component summary scores (MCS)...
March 9, 2017: Psychosomatic Medicine
https://www.readbyqxmd.com/read/28277345/a-treat-to-target-strategy-preserves-work-capacity-in-a-rheumatoid-arthritis-inception-cohort-treated-with-combination-conventional-dmard-therapy
#14
Mihir D Wechalekar, Stephen Quinn, Susan Lester, Robert G Metcalf, Ella Shanahan, Jennifer G Walker, Malcolm D Smith, Catherine L Hill, E Michael Shanahan, Susanna M Proudman
OBJECTIVES: Quantification of work disability in patients with early rheumatoid arthritis (RA) receiving conventional DMARDs according to a treat-to-target strategy. METHODS: This is a retrospective cohort analysis of RA patients who received combination conventional DMARDs, escalated to achieve DAS28(ESR) remission and completed an annual work and arthritis questionnaire. Random effect mixed modeling was used to assess associations between average hours worked per week (HWPW), and baseline prognostic factors...
April 2017: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
https://www.readbyqxmd.com/read/28269999/baseline-mri-bone-erosion-predicts-the-subsequent-radiographic-progression-in-early-rheumatoid-arthritis-patients-who-achieved-sustained-good-clinical-response
#15
Mami Tamai, Kazuhiko Arima, Yoshikazu Nakashima, Junko Kita, Masataka Umeda, Shoichi Fukui, Ayako Nishino, Takahisa Suzuki, Yoshiro Horai, Akitomo Okada, Tomohiro Koga, Shin-Ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Satoshi Yamasaki, Hideki Nakamura, Tomoki Origuchi, Kiyoshi Aoyagi, Masataka Uetani, Katsumi Eguchi, Atsushi Kawakami
OBJECTIVE: To examine whether magnetic resonance imaging (MRI) findings at baseline predict radiographic progression in early-stage rheumatoid arthritis (RA) patients who have achieved sustained good clinical response. METHODS: This is a sub-analysis from the one-year observational study of Nagasaki University Early Arthritis Cohort. Definition of 'good clinical response' was a decrement of disease activity score (DAS) 28 ≧ 1.2 at three months with achievement of DAS28 remission through 6-12 months...
March 8, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/28261973/predictors-of-severe-radiographic-progression-in-patients-with-early-rheumatoid-arthritis-prospective-observational-cohort-study
#16
Young Bin Joo, So-Young Bang, Jeong Ah Ryu, Seunghun Lee, Hye-Soon Lee, Sang-Cheol Bae
AIM: To identify predictors of severe radiographic progression in patients with early rheumatoid arthritis (ERA). METHODS: A total of 374 patients with ERA were selected from a Korean prospective cohort. Based on their annual Sharp/Van der Heijde modified score changes (ΔSHS/year), patients were classified into severe and no progression groups. Predictors of severe progression were evaluated using a multivariable logistic regression. RESULTS: After a mean follow-up duration of 4...
March 5, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28213564/seven-year-tolerability-profile-of-glucocorticoids-use-in-early-rheumatoid-arthritis-data-from-the-espoir-cohort
#17
Camille Roubille, Nathalie Rincheval, Maxime Dougados, René-Marc Flipo, Jean-Pierre Daurès, Bernard Combe
OBJECTIVE: To explore the 7-year tolerability profile of glucocorticoids (GC) for early rheumatoid arthritis (RA). METHODS: We examined data for 602 patients with RA from the early arthritis Etude et Suivi des POlyarthrites Indifférenciées Récentes (ESPOIR) cohort (<6 months disease duration) stratified into two groups: with or without GC treatment at least once during follow-up (median 7 years (IQR 0.038-7.65)). The main outcome was a composite of death, cardiovascular disease (including myocardial ischaemia, cerebrovascular accident and heart failure), severe infection and fracture...
February 17, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28205333/longitudinal-study-of-clinical-prognostic-factors-in-patients-with-early-rheumatoid-arthritis-the-predict-study
#18
Paul Bird, Dave Nicholls, Rina Barrett, Julien de Jager, Hedley Griffiths, Lynden Roberts, Kathleen Tymms, Philip McCloud, Geoffrey Littlejohn
AIM: To assess the association between baseline clinical prognostic factors and subsequent Disease Activity Score of 28 joints (DAS28) remission in early rheumatoid arthritis (RA). METHODS: Data were collected using point of care clinical software from participating rheumatology centres. Patients aged 18 years or over whose date of clinical onset of RA was within the previous 12-24 months, who had at least 6 months of follow-up data and a DAS28-ESR (erythrocyte sedimentation rate) score recorded between 12 and 24 months from first being seen for RA were included...
February 16, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28198158/only-rheumatoid-factor-positive-subset-of-anti-citrullinated-peptide-protein-antibody-negative-rheumatoid-arthritis-may-seroconvert-to-anti-citrullinated-peptide-protein-antibody-positive
#19
Ryosuke Hiwa, Koichiro Ohmura, Shuichiro Nakabo, Chikashi Terao, Kosaku Murakami, Ran Nakashima, Yoshitaka Imura, Naoichiro Yukawa, Hajime Yoshifuji, Motomu Hashimoto, Moritoshi Furu, Hiromu Ito, Takao Fujii, Tsuneyo Mimori
AIM: Anti-citrullinated peptide/protein antibody (ACPA) has been reported to occur in about 60% of patients with early rheumatoid arthritis (RA), and about 80% in patients with established RA. While ACPA seroconversion is possible, previous reports have shown that it rarely occurs. We retrospectively determined the proportion of patients who underwent ACPA seroconversion and described the clinical characteristics of these cases. METHODS: ACPA-negative RA patients who had undergone ACPA assessment more than once with an interval of 3 months or longer were investigated for ACPA seroconversion...
February 15, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28153828/clinical-benefit-of-1-year-certolizumab-pegol-czp-add-on-therapy-to-methotrexate-treatment-in-patients-with-early-rheumatoid-arthritis-was-observed-following-czp-discontinuation-2-year-results-of-the-c-opera-study-a-phase-iii-randomised-trial
#20
Tatsuya Atsumi, Yoshiya Tanaka, Kazuhiko Yamamoto, Tsutomu Takeuchi, Hisashi Yamanaka, Naoki Ishiguro, Katsumi Eguchi, Akira Watanabe, Hideki Origasa, Shinsuke Yasuda, Yuji Yamanishi, Yasuhiko Kita, Tsukasa Matsubara, Masahiro Iwamoto, Toshiharu Shoji, Osamu Togo, Toshiyuki Okada, Désirée van der Heijde, Nobuyuki Miyasaka, Takao Koike
OBJECTIVES: To investigate the clinical impact of 1-year certolizumab pegol (CZP) therapy added to the first year of 2-year methotrexate (MTX) therapy, compared with 2-year therapy with MTX alone. METHODS: MTX-naïve patients with early rheumatoid arthritis (RA) with poor prognostic factors were eligible to enter Certolizumab-Optimal Prevention of joint damage for Early RA (C-OPERA), a multicentre, randomised, controlled study, which consisted of a 52-week double-blind (DB) period and subsequent 52-week post treatment (PT) period...
February 2, 2017: Annals of the Rheumatic Diseases
keyword
keyword
79920
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"