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https://www.readbyqxmd.com/read/28629689/advanced-power-doppler-technique-increases-synovial-vascularity-detection-in-patients-with-rheumatoid-arthritis
#1
Davide Orlandi, Salvatore Gitto, Silvia Perugin Bernardi, Angelo Corazza, Luca De Flaviis, Enzo Silvestri, Marco Amedeo Cimmino, Luca Maria Sconfienza
We compared the diagnostic performance of an advanced power Doppler technique (superb microvascular imaging [SMI]) with that of power Doppler Imaging (PDI) and B-mode ultrasound (US) in patients with early rheumatoid arthritis (RA) and RA under treatment with rituximab. Thirty patients (21 women aged 45 ± 11 y) affected by RA with remission to moderate disease activity were examined. Both hand joints were evaluated using US, PDI and SMI. Two radiologists reviewed all video clips and evaluated synovial vascularity intensity using a semi-quantitative scoring system...
June 16, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28629188/serum-biomarkers-for-discrimination-between-hepatitis-c-related-arthropathy-and-early-rheumatoid-arthritis
#2
Isabela Siloşi, Lidia Boldeanu, Viorel Biciuşcă, Maria Bogdan, Carmen Avramescu, Citto Taisescu, Vlad Padureanu, Mihail Virgil Boldeanu, Anica Dricu, Cristian Adrian Siloşi
In the present study, we aimed to estimate the concentrations of cytokines (interleukin 6, IL-6, tumor necrosis factor-α, TNF-α) and auto-antibodies (rheumatoid factor IgM isotype, IgM-RF, antinuclear auto-antibodies, ANA, anti-cyclic citrullinated peptide antibodies IgG isotype, IgG anti-CCP3.1, anti-cardiolipin IgG isotype, IgG anti-aCL) in serum of patients with eRA (early rheumatoid arthritis) and HCVrA (hepatitis C virus-related arthropathy) and to assess the utility of IL-6, TNF-α together with IgG anti-CCP and IgM-RF in distinguishing between patients with true eRA and HCVrA, in the idea of using them as differential immunomarkers...
June 19, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28622462/-determinants-of-perceived-health-non-improvement-in-early-rheumatoid-arthritis-patients-with-favorable-treatment-outcomes
#3
M A H Oude Voshaar, L M M Steunebrink, E Taal, H E Vonkeman, T R Zijlstra, M A F J van de Laar
OBJECTIVE: The aim of this study was to explore the association between achieving favorable clinical outcomes and patients' perceived change in overall health status after 12 months of treat to target (T2T) in patients with early rheumatoid arthritis and to identify determinants of subjective non-improvement. METHODS: Baseline and 12 month data of patients included in the Dutch Rheumatoid Arthritis Monitoring remission induction cohort study with at least a moderate EULAR response after 1 year were selected for analysis...
June 16, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28611080/magnetic-resonance-imaging-assessed-inflammation-in-the-wrist-is-associated-with-patient-reported-physical-impairment-global-assessment-of-disease-activity-and-pain-in-early-rheumatoid-arthritis-longitudinal-results-from-two-randomised-controlled-trials
#4
Daniel Glinatsi, Joshua F Baker, Merete L Hetland, Kim Hørslev-Petersen, Bo J Ejbjerg, Kristian Stengaard-Pedersen, Peter Junker, Torkell Ellingsen, Hanne M Lindegaard, Ib Hansen, Tine Lottenburger, Jakob M Møller, Lykke Ørnbjerg, Aage Vestergaard, Anne Grethe Jurik, Henrik S Thomsen, Trine Torfing, Signe Møller-Bisgaard, Mette B Axelsen, Mikkel Østergaard
OBJECTIVES: To examine whether MRI assessed inflammation and damage in the wrist of patients with early rheumatoid arthritis (RA) are associated with patient-reported outcomes (PROs). METHODS: Wrist and hand MRIs of 210 patients with early RA from two investigator-initiated, randomised controlled studies (CIMESTRA/OPERA) were assessed according to the Outcome Measures in Rheumatology RA MRI score (RAMRIS) for synovitis, tenosynovitis, osteitis, bone erosions and joint space narrowing (JSN) at baseline, 1 and 5 years follow-up...
June 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28601838/are-dietary-vitamin-d-omega-3-fatty-acids-and-folate-associated-with-treatment-results-in-patients-with-early-rheumatoid-arthritis-data-from-a-swedish-population-based-prospective-study
#5
Cecilia Lourdudoss, Alicja Wolk, Lena Nise, Lars Alfredsson, Ronald van Vollenhoven
BACKGROUND: Dietary intake of vitamin D and omega-3 fatty acids (FA) may be associated with superior response to antirheumatic treatments. In addition, dietary folate intake may be associated with worse response to methotrexate (MTX). The aim of this study was to investigate the association between dietary vitamin D, omega-3 FA, folate and treatment results of disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis (RA). METHODS: This prospective study was based on data from the Epidemiological Investigation of Rheumatoid Arthritis (EIRA) study, and included 727 patients with early RA from 10 hospitals in Sweden...
June 10, 2017: BMJ Open
https://www.readbyqxmd.com/read/28582403/vitamin-d-and-immunomodulation-in-early-rheumatoid-arthritis-a-randomized-double-blind-placebo-controlled-study
#6
Ilaria Buondonno, Guido Rovera, Francesca Sassi, Micol Maria Rigoni, Claudia Lomater, Simone Parisi, Raffaele Pellerito, Giovanni Carlo Isaia, Patrizia D'Amelio
The aim of this study was to evaluate differences in T helper cell sub-types and osteoclast (OCs) precursors in peripheral blood between patients affected by early rheumatoid arthritis (eRA) and healthy controls. The effect of administration of cholecalcipherol on clinical and laboratory parameters was subsequently evaluated, by a parallel, randomized double blind, placebo controlled trial. Thirty nine eRA patients and 31 age-matched controls were enrolled and compared for levels of 25OH vitamin D, T helper cell sub-types, OCs precursors including both classical and non-classical and pro-inflammatory cytokines at baseline...
2017: PloS One
https://www.readbyqxmd.com/read/28581281/a-case-of-rheumatoid-vasculitis-involving-hepatic-artery-in-early-rheumatoid-arthritis
#7
Ji Eun Lee, In Je Kim, Min Sun Cho, Jisoo Lee
Rheumatoid vasculitis is a rare, but most serious extra-articular complications of long-standing, seropositive rheumatoid arthritis (RA). Vasculitis of hepatic artery is an extremely rare but severe manifestation of rheumatoid vasculitis. A 72-year-old woman who presented with polyarthralgia for 2 months was diagnosed with early RA. Since she had manifestations of livedo reticularis, and liver dysfunction which was atypical for RA patients, a percutaneous needle liver biopsy was performed revealing arteritis of a medium-sized hepatic artery...
July 2017: Journal of Korean Medical Science
https://www.readbyqxmd.com/read/28580826/bone-mineral-density-loss-in-clinically-suspect-arthralgia-is-associated-with-subclinical-inflammation-and-progression-to-clinical-arthritis
#8
L Mangnus, H W van Steenbergen, M Reijnierse, J Kälvesten, Ahm van der Helm-Van Mil
OBJECTIVE: Peripheral bone mineral density (BMD) may be decreased in early rheumatoid arthritis (RA) but it is unknown whether BMD loss emerges before arthritis is clinically apparent. We aimed to study whether BMD loss occurs in patients with clinically suspect arthralgia (CSA), and whether it is associated with progression to clinical arthritis and magnetic resonance imaging (MRI)-detected subclinical inflammation. METHOD: Patients with CSA had arthralgia for <1 year and were at risk of progressing to RA according to their rheumatologists...
June 5, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28573370/association-of-tumor-necrosis-factor-%C3%AE-g-308a-genetic-variant-with-matrix-metalloproteinase-9-activity-and-joint-destruction-in-early-rheumatoid-arthritis
#9
Sonja Stojanovic, Bojana Stamenkovic, Tatjana Jevtovic Stoimenov, Jovan Nedovic, Valentina Zivkovic, Milena Despotovic, Dusica Pavlovic
Matrix metalloproteinases (MMPs) are the key enzymes responsible for the joint destruction. Their activity is regulated by the level of proinflammatory cytokines. The aim of this study was to examine the impact of TNF-α G-308A polymorphism on MMP-9 levels in blood plasma (BP) and synovial fluid (SF) of patients with rheumatoid arthritis (RA) and their role in progression of joint destruction. One hundred thirty-four subjects were enrolled in this study. TNF-α G-308A polymorphism was determined using PCR-RFLP method...
June 1, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28572711/buprenorphine-alters-inflammatory-and-oxidative-stress-molecular-markers-in-arthritis
#10
Mahadevappa Hemshekhar, Vidyanand Anaparti, Carol Hitchon, Neeloffer Mookherjee
Buprenorphine is recommended for use as an analgesic in animal models including in murine models of collagen-induced arthritis (CIA). However, the effect of buprenorphine on the expression of disease-associated biomarkers is not well defined. We examined the effect of buprenorphine administration on disease progression and the expression of inflammatory and oxidative stress markers, in a murine model of CIA. Buprenorphine administration altered the expression of cytokines, IFN-γ, IL-6, and MMP-3, and oxidative markers, for example, iNOS, superoxide dismutase (SOD1), and catalase (CAT), in the CIA mice...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28511291/fatigue-older-age-higher-body-mass-index-and-female-gender-predict-worse-disability-in-early-rheumatoid-arthritis-despite-treatment-to-target-a-comparison-of-two-observational-cohort-studies-from-the-united-kingdom
#11
Sarah Twigg, Elizabeth M A Hensor, Jane Freeston, Ai Lyn Tan, Paul Emery, Alan Tennant, Ann W Morgan
OBJECTIVES: Compare disease activity and disability over 2 years in early rheumatoid arthritis (RA) before and after implementation of treat to target (T2T) and identify predictors of adverse outcome. METHODS: Yorkshire Early Arthritis Register (YEAR) recruited 725 patients with early RA between 2002-2009, treated with a step-up approach. The IACON study (Inflammatory Arthritis CONtinuum) recruited cases between 2010-2014 and treated to target. 384 IACON cases met 2010 ACR/EULAR criteria...
May 16, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28510734/predictors-of-and-outcomes-following-orthopaedic-joint-surgery-in-patients-with-early-rheumatoid-arthritis-followed-for-20-years
#12
James M Gwinnutt, Deborah P M Symmons, Alexander J MacGregor, Jacqueline R Chipping, Chloe Lapraik, Tarnya Marshall, Mark Lunt, Suzanne M M Verstappen
Objectives.: To analyse predictors and outcomes of major orthopaedic surgery in a cohort of RA patients followed for 20 years. Methods.: Patients were recruited to the Norfolk Arthritis Register from 1990 to 1994. Demographic and clinical variables (including the HAQ and swollen and tender joint counts) were assessed at baseline; the 2010 ACR/EULAR RA classification criteria were applied. Patients reported incident comorbidities and major orthopaedic joint surgery (replacement, synovectomy, fusion, excision) when reassessed at years 1, 2, 3, 5, 7, 10, 15 and 20...
May 16, 2017: Rheumatology
https://www.readbyqxmd.com/read/28509333/altered-glycan-accessibility-on-native-immunoglobulin-g-complexes-in-early-rheumatoid-arthritis-and-its-changes-during-therapy
#13
Judith Stümer, Mona H C Biermann, Jasmin Knopf, Iryna Magorivska, Alf Kastbom, Anna Svärd, Christina Janko, Rostyslav Bilyy, Georg Schett, Christopher Sjöwall, Martin Herrmann, Luis E Muñoz
The goal of this study was to investigate the glycosylation profile of native IgG present in serum immune complexes in patients with rheumatoid arthritis (RA). To accomplish this, lectin binding assays, detecting the accessibility of glycans present on IgG-containing immune complexes by biotinylated lectins were employed. Lectins capturing fucosyl residues (AAL), fucosylated tri-mannose N-glycan core sites (LCA), terminal sialic acid residues (SNA) and O-glycosidically-linked galactose/N-acetylgalactosamine (GalNac-L) were used...
May 16, 2017: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/28482738/hepcidin-plasma-levels-are-not-associated-with-changes-in-haemoglobin-in-early-rheumatoid-arthritis-patients
#14
R D Østgård, H Glerup, A G Jurik, T W Kragstrup, K Stengaard-Pedersen, M L Hetland, K Hørslev-Petersen, P Junker, B W Deleuran
OBJECTIVE: A reduction in haemoglobin level is a frequent complication among rheumatoid arthritis (RA) patients. Hepcidin has been linked to disturbed erythropoiesis. The objective of this study was to investigate the longitudinal changes in hepcidin in patients with early RA. METHOD: Hepcidin plasma concentrations were measured by enzyme-linked immunosorbent assay in patients with early RA (n = 80) and healthy volunteers (HV, n = 40). Haemoglobin and other iron-related proteins were also measured...
May 9, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28464477/smoking-behavior-changes-in-the-early-rheumatoid-arthritis-period-and-risk-of-mortality-during-36-years-of-prospective-follow-up
#15
Jeffrey A Sparks, Shun-Chiao Chang, Uyen-Sa D T Nguyen, Medha Barbhaiya, Sara K Tedeschi, Bing Lu, Karen H Costenbader, Yuqing Zhang, Hyon K Choi, Elizabeth W Karlson
OBJECTIVE: We investigated whether rheumatoid arthritis (RA) diagnosis influences smoking behavior changes and whether these changes were associated with mortality. METHODS: We identified an incident RA cohort in the Nurses' Health Study (NHS, 1976-2012). Behavioral data were collected through biennial questionnaires. We created a comparison cohort, matching RA cases to women without RA by age and calendar year at the index date of RA diagnosis. To investigate smoking behavior changes in the early RA period, sustained cessation was defined as permanently quitting within four years of RA/index date...
May 2, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28460018/evaluation-of-the-diagnostic-accuracy-of-hand-and-foot-mri-for-early-rheumatoid-arthritis
#16
Wouter P Nieuwenhuis, Hanna W van Steenbergen, Lukas Mangnus, Elize C Newsum, Johan L Bloem, Tom W J Huizinga, Saskia le Cessie, Monique Reijnierse, Annette H M van der Helm-van Mil
Objectives.: To assess the diagnostic value of MRI for early RA. In some RA patients, a classifiable diagnosis cannot be made at first presentation; these patients present with unclassified arthritis (UA). The use of MRI for early diagnosis of RA is recommended, yet the evidence for its reliability is limited. Methods.: MRI of hand and foot was performed in 589 early arthritis patients included in the Leiden Early Arthritis Clinic (229 presented with RA, 159 with other arthritides and 201 with UA)...
April 27, 2017: Rheumatology
https://www.readbyqxmd.com/read/28450312/long-term-outcome-is-better-when-a-methotrexate-based-treatment-strategy-is-combined-with-10-mg-prednisone-daily-follow-up-after-the-second-computer-assisted-management-in-early-rheumatoid-arthritis-trial
#17
M Safy, Jwg Jacobs, N D IJff, Jwj Bijlsma, J M van Laar, Mjh de Hair
OBJECTIVES: In the second Computer-Assisted Management in Early Rheumatoid Arthritis trial, patients had started with methotrexate and 10 mg prednisone (MTX+pred) or placebo (MTX+plac). After the trial, prednisone was tapered and stopped, if possible. The objective was to compare, during the post-trial follow-up between the two former strategy groups, initiation of the first biological disease-modifying antirheumatic drug (bDMARD), radiographic outcome and onset of glucocorticoid (GC)-related comorbidities...
April 27, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28440350/high-frequency-ultrasonography-of-the-hand-versus-anti-ra33-evaluation-in-early-rheumatoid-arthritis-a-pilot-study
#18
Andreea Lili Barbulescu, Paulina Lucia Ciurea, Carmen Mitran, Beatrice Andreea Chisalau, Cristina Dorina Parvanescu, Sineta Cristina Firulescu, Maria Balasoiu, Mihail Virgil Boldeanu, Horatiu Popoviciu, Florentin Ananu Vreju
AIM: Accurate diagnosis and early treatment in rheumatoid arthritis (RA) can lead to a good outcome and a correct management of the disease. We aimed toinvestigate the prognostic value of anti-RA33 antibodies, by evaluating the relationship with ultrasonographic (US) findings in patients with early RA. MATERIAL AND METHODS: We performed a prospective study which included 29 patients, diagnosed with early RA according to the ACR/EULAR 2010 criteria and 21 sex and age-matched control subjects...
April 22, 2017: Medical Ultrasonography
https://www.readbyqxmd.com/read/28439423/rheumatoid-arthritis-what-do-mri-and-ultrasound-show
#19
EDITORIAL
Iwona Sudoł-Szopińska, Lennart Jans, James Teh
Rheumatoid arthritis is the most common inflammatory arthritis, affecting approximately 1% of the world's population. Its pathogenesis has not been completely understood. However, there is evidence that the disease may involve synovial joints, subchondral bone marrow as well as intra- and extraarticular fat tissue, and may lead to progressive joint destruction and disability. Over the last two decades, significant improvement in its prognosis has been achieved owing to new strategies for disease management, the emergence of new biologic therapies and better utilization of conventional disease-modifying antirheumatic drugs...
March 2017: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28408733/high-performance-liquid-chromatography-hplc-quantification-of-liposome-delivered-doxorubicin-in-arthritic-joints-of-collagen-induced-arthritis-rats
#20
Hongqing Niu, Menghua Xu, Shuangtian Li, Junwei Chen, Jing Luo, Xiangcong Zhao, Chong Gao, Xiaofeng Li
BACKGROUND Neoangiogenesis occurring in inflamed articular synovium in early rheumatoid arthritis (RA) is characterized by enhanced vascular permeability that allows nanoparticle agents, including liposomes, to deliver encapsulated drugs to arthritic joints and subsequently improve therapeutic efficacy and reduce adverse effects. However, the targeting distribution of liposomes in arthritic joints during RA has not been quantitatively demonstrated. We performed this study to evaluate the targeting distribution of PEGylated doxorubicin liposomes in the arthritic joints of collagen-induced arthritis (CIA) rats by high-performance liquid chromatography (HPLC)...
April 14, 2017: Medical Science Monitor Basic Research
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