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"early rheumatoid arthritis"

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https://www.readbyqxmd.com/read/29336711/circulating-serum-interleukin-6-serum-chitinase-3-like-protein-1-and-plasma-vascular-endothelial-growth-factor-are-not-predictive-for-remission-and-radiographic-progression-in-patients-with-early-rheumatoid-arthritis-post-hoc-explorative-and-validation-studies
#1
C H Brahe, C Dehlendorff, M Østergaard, J S Johansen, L M Ørnbjerg, K Hørslev-Petersen, K Stengaard-Pedersen, P Junker, T Ellingsen, H Lindegaard, I Hansen, T Lottenburger, S Jacobsen, A G Jurik, M L Hetland
OBJECTIVE: To investigate serum interleukin-6 (IL-6), serum chitinase-3-like protein-1 (YKL-40), and plasma vascular endothelial growth factor (VEGF) as measures of disease activity and predictors of clinical remission and radiographic progression in two early rheumatoid arthritis (RA) randomized controlled trials (RCTs). METHOD: Treatment-naïve patients with early RA (< 6 months' duration) and active disease, participating in two investigator-initiated RCTs, were treated according to a predefined treat-to-target algorithm aiming at inflammatory control, using methotrexate (MTX) + cyclosporine versus MTX + placebo (CIMESTRA study, n = 150, 5 year follow-up) or MTX + adalimumab versus MTX + placebo (OPERA study, n = 180, 2 year follow-up)...
January 16, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29321158/response-to-calprotectin-is-not-independent-from-baseline-erosion-in-predicting-radiological-progression-in-early-rheumatoid-arthritis-by-chevreau-et-al
#2
Maria Karolina Jonsson, Nina Paulshus Sundlisæter, Hilde Haugedal Nordal, Hilde Berner Hammer, Anna-Birgitte Aga, Désirée van der Heijde, Tore Kristian Kvien, Bjørg-Tilde Svanes Fevang, Siri Lillegraven, Espen Andre Haavardsholm
No abstract text is available yet for this article.
January 10, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29318921/-18f-sodium-fluoride-positron-emission-tomography-computed-tomography-a-predictor-of-early-rheumatoid-arthritis-a-case-report
#3
S B Gram, S Hess, P Ahlquist, P F Høilund-Carlsen, T Ellingsen
No abstract text is available yet for this article.
January 10, 2018: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/29316201/women-s-situation-specific-strategies-in-managing-participation-restrictions-due-to-early-rheumatoid-arthritis-a-gender-comparison
#4
Gunnel Östlund, Mathilda Björk, Ingrid Thyberg, Eva Valtersson, Annette Sverker
INTRODUCTION: The present study explored how women describe their use of situation-specific strategies when managing rheumatoid arthritis (RA). The aim was also to compare women's strategies with those of men, and see the extent to which they used the same strategies. METHODS: The data were collected using semi-structured interviews based on the critical incident technique. The sample consisted of women with early rheumatic arthritis (n = 34), and the results were compared with data reported in a previous study on men (n = 25) from the same cohort...
January 9, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29297100/effect-of-daily-low-dose-prednisone-divided-or-single-daily-dose-in-the-treatment-of-african-americans-with-early-rheumatoid-arthritis
#5
Doyt L Conn, Athan Tiliakos, Gaobin Bao, Shuling Li, Kirk A Easley
Determine the effect of daily low divided or single daily dose of prednisone on the longitudinal change in the number of tender and swollen joints and HAQ scores in African Americans (AA) with early rheumatoid arthritis (RA) from the Consortium for the Longitudinal Evaluation of African Americans with Early Rheumatoid Arthritis (CLEAR) 1 Registry. In a prospective, multicenter observational cohort study, AA with early RA were enrolled and followed longitudinally for up to 5 years. 345 were enrolled. The mean age at enrollment was 51 years and 82% were women...
January 3, 2018: Clinical Rheumatology
https://www.readbyqxmd.com/read/29280011/high-burden-of-adverse-events-is-associated-with-reduced-remission-rates-in-early-rheumatoid-arthritis
#6
Laura Kuusalo, Kari Puolakka, Hannu Kautiainen, Anna Karjalainen, Timo Malmi, Leena Paimela, Marjatta Leirisalo-Repo, Vappu Rantalaiho
Adverse events (AEs) are common during disease-modifying antirheumatic drug (DMARD) treatment, but their influence on treatment results is unclear. We studied AEs in relation to disease activity in early rheumatoid arthritis (RA). Ninety-nine patients started intensive treatment with three conventional synthetic DMARDs (csDMARDs) and oral prednisolone, and were randomized to a 6-month induction treatment with infliximab or placebo. All AEs during the first 12 months of treatment were recorded. We scored each AE based on severity (scale 1-4) and defined the burden of AEs as the sum of these scores...
December 26, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/29246243/the-risk-of-malignancy-and-its-incidence-in-early-rheumatoid-arthritis-patients-treated-with-biologic-dmards
#7
Soo-Kyung Cho, Jiyoung Lee, Minkyung Han, Sang-Cheol Bae, Yoon-Kyoung Sung
BACKGROUND: Treatment with disease-modifying anti-rheumatic drugs (DMARDs) has raised concerns about the risk of malignancies in rheumatoid arthritis (RA) patients. However, the association between biologic DMARDs (bDMARDs) and malignancy in previous reports remains controversial. Therefore we aimed to estimate the incidence of malignancy in early RA patients and to evaluate the relative risk of malignancy with use of bDMARDs. METHODS: A retrospective cohort of incident RA patients was established using the Korean National Claims Database...
December 15, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29232938/factors-associated-with-time-to-diagnosis-from-symptom-onset-in-patients-with-early-rheumatoid-arthritis
#8
Soo-Kyoung Cho, Dam Kim, Soyoung Won, Jiyoung Lee, Chan-Bum Choi, Jung-Yoon Choe, Seung-Jae Hong, Jae-Bum Jun, Tae-Hwan Kim, Eunmi Koh, Hye-Soon Lee, Jisoo Lee, Dae-Hyun Yoo, Bo Young Yoon, Sang-Cheol Bae, Yoon-Kyoung Sung
Background/Aims: To identify the factors associated with time to diagnosis after symptom onset in patients with early rheumatoid arthritis (RA). Methods: Early RA patients with ≤ 1 year of disease duration in the KORean Observational study Network for Arthritis (KORONA) database were included in this analysis. Patients were further divided into two groups according to the time to diagnosis from symptom onset: the early diagnosis group (time to diagnosis ≤ 1 year) and the late diagnosis group (time to diagnosis > 1 year)...
December 15, 2017: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/29228959/micro-structural-bone-changes-in-early-rheumatoid-arthritis-persist-over-1-year%C3%A2-despite-use-of-disease-modifying-anti-rheumatic-drug-therapy
#9
Lynne M Feehan, Linda L Li, Heather A McKay
BACKGROUND: We used High Resolution - peripheral Quantitative CT (HR-pQCT) imaging to examine peri-articular bone quality in early rheumatoid arthritis (RA) and explore whether bone quality improved over 12-months in individuals receiving care consistent with practice guidelines. METHODS: A 1-year longitudinal cohort study (Baseline and 12-months) evaluating individuals with early RA compared to age/sex-matched peers. Personal demographic and health and lifestyle information were collected for all...
December 11, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29206659/what-are-the-dominant-cytokines-in-early-rheumatoid-arthritis
#10
Laura A Ridgley, Amy E Anderson, Arthur G Pratt
PURPOSE OF REVIEW: Rheumatoid arthritis is a systemic disease of evolving immune dysregulation that culminates in joint destruction and disability. The principle by which pro-inflammatory cytokines may be therapeutically targeted to abrogate disease is well established, but has yet to translate into reliable cures for patients. Emerging insights into cytokine-mediated pathobiology during rheumatoid arthritis development are reviewed, and their implications for future treatment strategies considered...
December 4, 2017: Current Opinion in Rheumatology
https://www.readbyqxmd.com/read/29204090/autoantibodies-c-reactive-protein-erythrocyte-sedimentation-rate-and-serum-cytokine-profiling-in-monitoring-of-early-treatment
#11
Edyta Brzustewicz, Izabella Henc, Agnieszka Daca, Maria Szarecka, Malgorzata Sochocka-Bykowska, Jacek Witkowski, Ewa Bryl
Introduction: Currently used clinical scale and laboratory markers to monitor patients with early rheumatoid arthritis (RA) seem to be not sufficient. It has been demonstrated that disease- related cytokines may be elevated very early in RA development and cytokines are considered as the biomarkers potentially useful for RA monitoring. Material and methods: The group of patients with undifferentiated arthritis (UA) developing RA (UA→RA) was identified from a total of 121 people with arthralgia...
2017: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/29200598/vitamin-d-status-disease-activity-and-endothelial-dysfunction-in-early-rheumatoid-arthritis-patients
#12
Alexandru Caraba, Viorica Crişan, Ioan Romoşan, Ioana Mozoş, Marius Murariu
Cardiovascular diseases represent important complications in rheumatoid arthritis (RA) patients, generated by an accelerated atherosclerosis. The aim of this study is represented by the assessment of the correlations between serum levels of vitamin D, disease activity, and endothelial dysfunction in patients with early RA. Material and Methods. The study was performed on a group of 35 patients with early RA and 35 healthy subjects matched for age and gender, as controls. In all studied subjects, the following were determined: inflammatory markers, insulin resistance, vitamin D levels, and endothelial dysfunction...
2017: Disease Markers
https://www.readbyqxmd.com/read/29195001/the-foot-as-a-barrier-in-patients-with-early-rheumatoid-arthritis-an-interview-study-among-swedish-women-and-men
#13
Mathilda Björk, Ingrid Thyberg, Eva Valtersson, Gunnel Östlund, Birgitta Stenström, Annette Sverker
OBJECTIVE: Foot impairments are related to reduced mobility and participation restrictions in daily activities in patients with established rheumatoid arthritis (RA). The new biological medications are effective and reduce disease activity, but not disability to the same extent. Foot impairments are assumed to be related to participation restrictions also in patients with early RA, diagnosed after the introduction of biological medications. The knowledge of foot impairments needs to be more explored after the introduction of biological disease-modifying drugs (bDMARDs)...
December 1, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29193840/overweight-and-obesity-reduce-the-likelihood-of-achieving-sustained-remission-in-early-rheumatoid-arthritis-results-from-the-canadian-early-arthritis-cohort-study
#14
Elizabeth Schulman, Susan J Bartlett, Orit Schieir, Kathleen M Andersen, Gilles Boire, Janet E Pope, Carol Hitchon, Shahin Jamal, Carter J Thorne, Diane Tin, Edward C Keystone, Boulos Haraoui, Susan M Goodman, Vivian P Bykerk, Catch Investigators
OBJECTIVE: Obesity is implicated in RA development, severity, outcomes and treatment response. We estimated the independent effects of overweight and obesity on ability to achieve sustained remission (sREM) in the three years following RA diagnosis. METHODS: Data were from the Canadian Early Arthritis Cohort, a multicenter observational trial of ERA patients treated by rheumatologists using guideline-based care. sREM was defined as DAS28 <2.6 for two consecutive visits...
November 30, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29193837/weight-change-during-the-early-rheumatoid-arthritis-period-and-risk-of-subsequent-mortality-in-women-with-rheumatoid-arthritis-and-matched-comparators
#15
Jeffrey A Sparks, Shun-Chiao Chang, Uyen-Sa Nguyen, Medha Barbhaiya, Sara K Tedeschi, Bing Lu, David J Kreps, Karen H Costenbader, Yuqing Zhang, Hyon K Choi, Elizabeth W Karlson
OBJECTIVE: To investigate whether weight change during the early rheumatoid arthritis (RA) period is associated with subsequent mortality and to evaluate whether there is an RA-specific effect. METHODS: We identified patients with incident RA during the Nurses' Health Study (NHS; 1976-2016) and created a comparison cohort by matching each RA patient with up to 10 non-RA comparators by age and calendar year of the RA diagnosis (index date). To capture weight change around the early RA period ("peri-RA/index"), we used weight measurements collected 2-4 years before and 2-4 years after the index date...
January 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29146743/testing-treat-to-target-outcomes-with-initial-methotrexate-monotherapy-compared-with-initial-tumour-necrosis-factor-inhibitor-adalimumab-plus-methotrexate-in-early-rheumatoid-arthritis
#16
Arthur Kavanaugh, Ronald F van Vollenhoven, Roy Fleischmann, Paul Emery, Iain Sainsbury, Stefan Florentinus, Su Chen, Benoît Guérette, Hartmut Kupper, Josef S Smolen
OBJECTIVES: To compare responses in patients with early rheumatoid arthritis (RA) initially treated with the tumour necrosis factor inhibitor (TNFi) adalimumab+methotrexate (MTX) versus MTX monotherapy who may have continued receiving MTX or switched to adalimumab rescue therapy after inadequate response to MTX. METHODS: OPTIMA enrolled MTX-naive patients with active RA for <1 year. This post hoc analysis determined the proportion of patients, stratified by initial treatment, who achieved 28-joint modified Disease Activity Score based on C reactive protein <3...
November 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29142030/plasma-microrna-profiles-in-patients-with-early-rheumatoid-arthritis-responding-to-adalimumab-plus-methotrexate-vs-methotrexate-alone-a-placebo-controlled-clinical-trial
#17
Jacob Sode, Sophine B Krintel, Anting Liu Carlsen, Merete L Hetland, Julia S Johansen, Kim Hørslev-Petersen, Kristian Stengaard-Pedersen, Torkell Ellingsen, Mark Burton, Peter Junker, Mikkel Østergaard, Niels H H Heegaard
OBJECTIVE: The aim was to identify plasma (i.e., cell-free) microRNA (miRNA) predicting antitumor necrosis and/or methotrexate (MTX) treatment response in patients enrolled in an investigator-initiated, prospective, double-blinded, placebo-controlled trial (The OPERA study, NCT00660647). METHODS: We included 180 disease-modifying antirheumatic drug-naive patients with early rheumatoid arthritis (RA) randomized to adalimumab (ADA; n = 89) or placebo (n = 91) in combination with MTX...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29125904/early-rheumatoid-arthritis-presentation-treatment-and-outcomes-in-aboriginal-patients-in-canada-a-canadian-early-arthritis-cohort-study-analysis
#18
Sujay Nagaraj, Cheryl Barnabe, Orit Schieir, Janet Pope, Susan J Bartlett, Gilles Boire, Edward Keystone, Diane Tin, Boulos Haraoui, J Carter Thorne, Vivian P Bykerk, Carol Hitchon
OBJECTIVE: Health inequities exist in chronic diseases for Aboriginal people. This study compared early rheumatoid arthritis (ERA) presentation, treatment and outcomes between Aboriginal and Caucasian patients in a large Canadian cohort study. METHODS: Longitudinal data from the Canadian early ArThritis CoHort (CATCH), a prospective multicenter ERA study, were analyzed for participants who self-identified as Aboriginal or Caucasian ethnicity. Disease characteristics at presentation, prognostic factors, frequency of remission and disease-modifying therapy strategies were contrasted between population groups...
November 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29119006/cost-utility-of-cobra-light-versus-cobra-therapy-in-patients-with-early-rheumatoid-arthritis-the-cobra-light-trial
#19
Marieke M Ter Wee, Veerle Mh Coupé, Debby den Uyl, Birgit S Blomjous, Esmee Kooijmans, Pit Jsm Kerstens, Mike T Nurmohamed, Dirkjan van Schaardenburg, Alexandre E Voskuyl, Maarten Boers, Willem F Lems
Objective: To evaluate if COmbinatie therapie Bij Reumatoïde Artritis (COBRA)-light therapy is cost-effective in treating patients with early rheumatoid arthritis (RA) compared with COBRA therapy. Methods: This economic evaluation was performed next to the open-label, randomised non-inferiority COBRA-light trial in 164 patients with early RA. Non-responders to COBRA or COBRA-light received etanercept (50 mg/week) for 3-6 months. The societal perspective analysis took medical direct, non-medical direct and indirect costs into account...
2017: RMD Open
https://www.readbyqxmd.com/read/29095992/radiographic-joint-damage-in-early-rheumatoid-arthritis-patients-comparing-tocilizumab-and-methotrexate-based-treat-to-target-strategies
#20
Xavier M Teitsma, Johannes W G Jacobs, Paco M J Welsing, Attila Pethö-Schramm, Michelle E A Borm, Jacob M van Laar, Floris P J G Lafeber, Johannes W J Bijlsma
Objective: To evaluate the progression of erosions and joint space narrowing (JSN) in feet and hands in the U-Act-Early trial. Methods: In this trial, 317 newly diagnosed DMARD-naïve RA patients initiated randomly tocilizumab, or step-up MTX or a combination of the two. Radiographs were scored at baseline and after 52 and 104 weeks using the Sharp-van der Heijde erosion and JSN score. Between the strategy arms, changes from baseline and the proportions of patients without radiographic progression (change from baseline ≤0) were compared...
October 31, 2017: Rheumatology
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