keyword
MENU ▼
Read by QxMD icon Read
search

"early rheumatoid arthritis"

keyword
https://www.readbyqxmd.com/read/29146743/testing-treat-to-target-outcomes-with-initial-methotrexate-monotherapy-compared-with-initial-tumour-necrosis-factor-inhibitor-adalimumab-plus-methotrexate-in-early-rheumatoid-arthritis
#1
Arthur Kavanaugh, Ronald van Vollenhoven, Roy M Fleischmann, Paul Emery, Iain Sainsbury, Stefan Florentinus, Su Chen, Benoît Guérette, Hartmut Kupper, Josef S Smolen
OBJECTIVES: To compare responses in patients with early rheumatoid arthritis (RA) initially treated with the tumour necrosis factor inhibitor (TNFi) adalimumab+methotrexate (MTX) versus MTX monotherapy who may have continued receiving MTX or switched to adalimumab rescue therapy after inadequate response to MTX. METHODS: OPTIMA enrolled MTX-naive patients with active RA for <1 year. This post hoc analysis determined the proportion of patients, stratified by initial treatment, who achieved28-joint modified Disease Activity Score based on C reactive protein <3...
November 16, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29142030/plasma-microrna-profiles-in-patients-with-early-rheumatoid-arthritis-responding-to-adalimumab-plus-methotrexate-vs-methotrexate-alone-a-placebo-controlled-clinical-trial
#2
Jacob Sode, Sophine B Krintel, Anting Liu Carlsen, Merete L Hetland, Julia S Johansen, Kim Hørslev-Petersen, Kristian Stengaard-Pedersen, Torkell Ellingsen, Mark Burton, Peter Junker, Mikkel Østergaard, Niels H H Heegaard
OBJECTIVE: The aim was to identify plasma (i.e., cell-free) microRNA (miRNA) predicting antitumor necrosis and/or methotrexate (MTX) treatment response in patients enrolled in an investigator-initiated, prospective, double-blinded, placebo-controlled trial (The OPERA study, NCT00660647). METHODS: We included 180 disease-modifying antirheumatic drug-naive patients with early rheumatoid arthritis (RA) randomized to adalimumab (ADA; n = 89) or placebo (n = 91) in combination with MTX...
November 15, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29125904/early-rheumatoid-arthritis-presentation-treatment-and-outcomes-in-aboriginal-patients-in-canada-a-canadian-early-arthritis-cohort-study-analysis
#3
Sujay Nagaraj, Cheryl Barnabe, Orit Schieir, Janet Pope, Susan J Bartlett, Gilles Boire, Edward Keystone, Diane Tin, Boulos Haraoui, J Carter Thorne, Vivian P Bykerk, Carol Hitchon
OBJECTIVE: Health inequities exist in chronic diseases for Aboriginal people. This study compared early rheumatoid arthritis (ERA) presentation, treatment and outcomes between Aboriginal and Caucasian patients in a large Canadian cohort study. METHODS: Longitudinal data from the Canadian early ArThritis CoHort (CATCH), a prospective multicenter ERA study, were analyzed for participants who self-identified as Aboriginal or Caucasian ethnicity. Disease characteristics at presentation, prognostic factors, frequency of remission and disease-modifying therapy strategies were contrasted between population groups...
November 10, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29119006/cost-utility-of-cobra-light-versus-cobra-therapy-in-patients-with-early-rheumatoid-arthritis-the-cobra-light-trial
#4
Marieke M Ter Wee, Veerle Mh Coupé, Debby den Uyl, Birgit S Blomjous, Esmee Kooijmans, Pit Jsm Kerstens, Mike T Nurmohamed, Dirkjan van Schaardenburg, Alexandre E Voskuyl, Maarten Boers, Willem F Lems
Objective: To evaluate if COmbinatie therapie Bij Reumatoïde Artritis (COBRA)-light therapy is cost-effective in treating patients with early rheumatoid arthritis (RA) compared with COBRA therapy. Methods: This economic evaluation was performed next to the open-label, randomised non-inferiority COBRA-light trial in 164 patients with early RA. Non-responders to COBRA or COBRA-light received etanercept (50 mg/week) for 3-6 months. The societal perspective analysis took medical direct, non-medical direct and indirect costs into account...
2017: RMD Open
https://www.readbyqxmd.com/read/29095992/radiographic-joint-damage-in-early-rheumatoid-arthritis-patients-comparing-tocilizumab-and-methotrexate-based-treat-to-target-strategies
#5
Xavier M Teitsma, Johannes W G Jacobs, Paco M J Welsing, Attila Pethö-Schramm, Michelle E A Borm, Jacob M van Laar, Floris P J G Lafeber, Johannes W J Bijlsma
Objective: To evaluate the progression of erosions and joint space narrowing (JSN) in feet and hands in the U-Act-Early trial. Methods: In this trial, 317 newly diagnosed DMARD-naïve RA patients initiated randomly tocilizumab, or step-up MTX or a combination of the two. Radiographs were scored at baseline and after 52 and 104 weeks using the Sharp-van der Heijde erosion and JSN score. Between the strategy arms, changes from baseline and the proportions of patients without radiographic progression (change from baseline ≤0) were compared...
October 31, 2017: Rheumatology
https://www.readbyqxmd.com/read/29079928/calcification-of-coronary-arteries-in-early-rheumatoid-arthritis-prior-to-anti-rheumatic-therapy
#6
Helen V Udachkina, Diana S Novikova, Tatiana V Popkova, Irina G Kirillova, Evgenia I Markelova, Elena L Luchikhina, Galina V Lukina, Valentin E Sinitsyn, Dmitry E Karateev, Eugeniy L Nasonov
Accelerated coronary atherosclerosis is common in patients with rheumatoid arthritis (RA). To examine coronary artery calcification (CAC) frequency and severity, its correlation with traditional risk factors (TRF) of cardiovascular diseases (CVD) and inflammatory markers in patients with early RA prior to anti-rheumatic therapy. RA adult patients (ACR/EULAR criteria, 2010, duration ≤ 12 months, without prior administration of disease-modifying anti-rheumatic drugs, glucocorticoids) underwent 32-row scanning for CAC scoring...
October 27, 2017: Rheumatology International
https://www.readbyqxmd.com/read/29051108/a-bayesian-model-that-jointly-considers-comparative-effectiveness-research-and-patients-preferences-may-help-inform-grade-recommendations-an-application-to-rheumatoid-arthritis-treatment-recommendations
#7
Glen S Hazlewood, Claire Bombardier, George Tomlinson, Deborah Marshall
OBJECTIVE: To estimate the preferred treatment for early rheumatoid arthritis (ERA) using a novel Bayesian approach that jointly considers patients' preferences and comparative effectiveness research STUDY DESIGN AND SETTING: We estimated the preferred treatment by using patients' preferences measured in a discrete-choice experiment to apply weights to benefit and harm outcomes from a network meta-analysis, and other considerations (dosing, rare adverse events). Using Bayesian analyses, we considered the variability in patients' preferences and the imprecision in both patients' preferences and the treatment effects; all key considerations in the GRADE approach...
October 16, 2017: Journal of Clinical Epidemiology
https://www.readbyqxmd.com/read/29041980/comparison-of-the-clinical-effectiveness-of-us-grading-scoring-system-vs-mri-in-the-diagnosis-of-early-rheumatoid-arthritis-ra
#8
Huajun Xu, Yingchun Zhang, Huimei Zhang, Caishan Wang, Pan Mao
BACKGROUND: As an irreversible disease, a treatment delay can negatively affect treatment response in rheumatoid arthritis (RA). Ultrasound and MRI have played an important role in assessing disease progression and response to treatment in RA for many years. The present study was designed to compare the diagnostic efficacy of ultrasound grading and MRI in early RA. METHODS: In this retrospective study, 62 early RA patients within 12 months of symptom onset were included...
October 17, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29029185/patient-reported-outcomes-in-newly-diagnosed-early-rheumatoid-arthritis-patients-treated-to-target-with-a-tocilizumab-or-methotrexate-based-strategy
#9
Xavier M Teitsma, Johannes W G Jacobs, Paco M J Welsing, Attila Pethö-Schramm, Michelle E A Borm, Lidy Hendriks, Natasja H A M Denissen, Jacob M van Laar, Floris P J G Lafeber, Johannes W J Bijlsma
Objective: To evaluate the effect of initiation of tocilizumab, with or without MTX, compared with MTX alone on patient-reported outcomes (PROs), in DMARD-naïve patients with early RA. Methods: In U-Act-Early, patients initiated treat-to-target step-up MTX, tocilizumab or tocilizumab plus MTX therapy. PROs assessed included the Functional Assessment of Chronic Illness Therapy-Fatigue, 36-item Short Form (SF-36), five dimensional EuroQol (EQ-5D) and the Revised Illness Perception Questionnaire...
September 23, 2017: Rheumatology
https://www.readbyqxmd.com/read/28990250/galectin-3-is-persistently-increased-in-early-rheumatoid-arthritis-ra-and-associates-with-anti-ccp-seropositivity-and-mri-bony-lesions-while-early-fibrosis-markers-correlate-with-disease-activity
#10
Saida Farah Issa, Anne Friesgaard Christensen, Hanne M Lindegaard, Merete L Hetland, Kim Hørslev-Petersen, Kristian Stengaard-Pedersen, Bo Jannik Ejbjerg, Tine Lottenburger, Torkell Ellingsen, Jens Kristian Pedersen, Kirsten Junker, Anders Svendsen, Ulrik Tarp, Mikkel Østergaard, Peter Junker
Galectin-3 has been suggested as a pro-inflammatory mediator in animal arthritis and rheumatoid arthritis (RA). We aimed to study the serum level of galectin-3 in patients with newly diagnosed RA and associations with disease profile, Magnetic Resonance Imaging (MRI) findings and seromarkers of synovial matrix inflammation. One hundred and sixty DMARD naïve patients newly diagnosed with RA were included (CIMESTRA study). Clinical, serological and imaging data were recorded before treatment and at 6 weeks, 3 and 12 months...
October 9, 2017: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/28968687/the-use-of-glucocorticoids-in-early-rheumatoid-arthritis
#11
Patrick Verschueren, Rene Westhovens
No abstract text is available yet for this article.
July 26, 2017: Rheumatology
https://www.readbyqxmd.com/read/28967710/personalized-diet-and-exercise-recommendations-in-early-rheumatoid-arthritis-a-feasibility-trial
#12
Stephanie Garner, Tanis Fenton, Liam Martin, Caitlin Creaser, Carolyn Johns, Cheryl Barnabe
BACKGROUND: Physical activity and diet have a positive influence on disease activity and cardiovascular risk in patients with rheumatoid arthritis (RA). OBJECTIVE: We tested the feasibility and effect of a brief individualized counselling intervention on physical activity levels and fitness, and dietary intake, compared with standard of care. METHODS: Thirty patients with inflammatory arthritis (<1 year duration) were assigned to standard of care or the intervention, which consisted of individualized visits with a dietetic intern and physiotherapist at two time points, to review age-specific strategies on diet and exercise...
October 2, 2017: Musculoskeletal Care
https://www.readbyqxmd.com/read/28967272/effects-of-psychosocial-factors-on-monitoring-treatment-effect-in-newly-diagnosed-rheumatoid-arthritis-patients-over-time-response-data-from-the-treach-study
#13
T M Kuijper, J J Luime, H Xiong, Php de Jong, Pahm van der Lubbe, D van Zeben, I Tchetverikov, Jmw Hazes, Aeam Weel
OBJECTIVES: To investigate whether, apart from effects of patient- and disease-related factors, psychosocial factors have additional effects on disease activity; and which factors are most influential during the first year of treatment in early rheumatoid arthritis (RA). METHOD: The study assessed 15 month follow-up data from patients in tREACH, a randomized clinical trial comparing initial triple disease-modifying anti-rheumatic drug therapy to methotrexate monotherapy, with glucocorticoid bridging in both groups...
October 2, 2017: Scandinavian Journal of Rheumatology
https://www.readbyqxmd.com/read/28955481/methotrexate-and-low-dose-prednisolone-downregulate-osteoclast-function-by-decreasing-receptor-activator-of-nuclear-factor-%C3%AE%C2%BA%C3%AE-expression-in-monocytes-from-patients-with-early-rheumatoid-arthritis
#14
Inês Pedro Perpétuo, Joana Caetano-Lopes, Ana Maria Rodrigues, Raquel Campanilho-Marques, Cristina Ponte, Helena Canhão, Mari Ainola, João Eurico Fonseca
OBJECTIVE: Rheumatoid arthritis (RA) is a systemic, immune-mediated inflammatory disease that ultimately leads to bone erosions and joint destruction. Methotrexate (MTX) slows bone damage but the mechanism by which it acts is still unknown. In this study, we aimed to assess the effect of MTX and low-dose prednisolone (PDN) on circulating osteoclast (OC) precursors and OC differentiation in patients with RA. METHODS: Patients with RA before and at least 6 months after MTX therapy were analysed and compared with healthy donors...
2017: RMD Open
https://www.readbyqxmd.com/read/28952204/disease-activity-trajectories-in-early-rheumatoid-arthritis-following-intensive-dmard-therapy-over-3-years-association-with-persistence-to-therapy
#15
Nasir Wabe, Jessica Wojciechowski, Mihir D Wechalekar, Leslie G Cleland, Leah McWilliams, Anita Lee, Susanna Proudman, Michael D Wiese
OBJECTIVE: To identify the disease activity trajectories during intensive triple disease modifying anti-rheumatic drug (DMARD) therapy over 3 years in rheumatoid arthritis (RA) patients and to evaluate the association with treatment persistence. METHODS: Disease Activity Score in 28 joints, baseline risk factors and medication usage were obtained from a longitudinal observational cohort of early RA patients, most of whom were treated with combination DMARD therapy consisting of methotrexate, sulfasalazine and hydroxychloroquine...
October 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28950430/low-hemoglobin-predicts-radiographic-damage-progression-in-early-rheumatoid-arthritis-secondary-analysis-from-a-phase-iii-trial
#16
Burkhard Möller, Judith Everts-Graber, Stefan Florentinus, Yihan Li, Hartmut Kupper, Axel Finckh
OBJECTIVE: To study low blood hemoglobin concentrations as a predictor of radiographic damage progression in patients with rheumatoid arthritis (RA). METHODS: Post-hoc analyses were performed in patients from the PREMIER trial with early RA undergoing two years of adalimumab (ADA), methotrexate (MTX), or ADA+MTX combination therapy. Low disease activity was defined by the 28-joint based disease activity score DAS28-CRP <3.2, and clinical response by 20% improvement in the American College of Rheumatology response criteria at week 24...
September 26, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28948174/intestinal-dysbiosis-and-rheumatoid-arthritis-a-link-between-gut-microbiota-and-the-pathogenesis-of-rheumatoid-arthritis
#17
REVIEW
Gabriel Horta-Baas, María Del Socorro Romero-Figueroa, Alvaro José Montiel-Jarquín, María Luisa Pizano-Zárate, Jaime García-Mena, Ninfa Ramírez-Durán
Characterization and understanding of gut microbiota has recently increased representing a wide research field, especially in autoimmune diseases. Gut microbiota is the major source of microbes which might exert beneficial as well as pathogenic effects on human health. Intestinal microbiome's role as mediator of inflammation has only recently emerged. Microbiota has been observed to differ in subjects with early rheumatoid arthritis compared to controls, and this finding has commanded this study as a possible autoimmune process...
2017: Journal of Immunology Research
https://www.readbyqxmd.com/read/28932748/insulin-resistance-in-early-rheumatoid-arthritis-is-associated-with-low-appendicular-lean-mass
#18
Raili Müller, Mart Kull, Margus Lember, Kaja Põlluste, Annika Valner, Riina Kallikorm
In established rheumatoid arthritis (RA), the presence of insulin resistance (IR) is well proven but, in the early stage of the disease, data are inconclusive. We evaluated the presence of IR and associations with body composition (BC) parameters among early RA (ERA) and control subjects. The study group consisted of 92 ERA and 321 control subjects. Using homeostatic model assessment of IR (HOMA-IR), the cut-off value for IR was 2.15. 56% of the ERA patients and 25% of the controls had IR. Of the BC parameters, patients with early RA had less fat-free mass and appendicular lean mass (ALM)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28932306/prevalence-of-asymptomatic-arterial-hypertension-and-its-correlation-with-inflammatory-activity-in-early-rheumatoid-arthritis
#19
Ismet H Bajraktari, Sylejman Rexhepi, Idriz Berisha, Ali Lahu, Avni Kryeziu, Bastri Durmishi, Halit Bajraktari, Elton Bahtiri
BACKGROUND: Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease that worsens during the course of the disease and can cause disability. Early RA refers to the onset of symptoms within the past 3 months. In RA, increased levels of mediators of inflammation may cause arterial stiffness consequently leading to arterial hypertension. AIM: The aim of this cross-sectional study was to assess the prevalence of asymptomatic arterial hypertension in early RA patients as well as the correlation with parameters of inflammation...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28879052/obesity-is-a-strong-predictor-of-worse-clinical-outcomes-and-treatment-responses-in-early-rheumatoid-arthritis-results-from-the-swefot-trial
#20
Adrian Levitsky, Kerstin Brismar, Ingiäld Hafström, Karen Hambardzumyan, Cecilia Lourdudoss, Ronald F van Vollenhoven, Saedis Saevarsdottir
OBJECTIVES: The aim of this paper was to analyse the impact of obesity, in addition to known predictors, on disease outcome in early rheumatoid arthritis (RA). METHODS: Body mass index (BMI) was available in 260 patients from the Swedish pharmacotherapy trial (SWEFOT). Differences in disease activity (DAS28), functional impairment (HAQ), pain (Visual Analogue Scale, VAS-pain) and radiographic damage were evaluated over 24 months between BMI categories (obese BMI >30, n=43; overweight BMI=25-29...
2017: RMD Open
keyword
keyword
79920
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"