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https://www.readbyqxmd.com/read/28050748/development-of-diagnostic-techniques-for-early-rheumatoid-arthritis-using-positron-emission-tomography-with-11-c-pk11195-and-11-c-ketoprofen-tracers
#1
Satoshi Nozaki, Naoko Ozaki, Shinobu Suzuki, Miki Goto, Aya Mawatari, Yuka Nakatani, Emi Hayashinaka, Yasuhiro Wada, Hisashi Doi, Yasuyoshi Watanabe
PURPOSE: In vivo detection of pathological insults during the early stages of rheumatoid synovitis is essential to allow early anti-inflammatory treatment for prevention of joint destruction. Whether rheumatoid synovitis pathology and the efficacy of therapies can be visualized by positron emission tomography (PET) tracers specific to the inflammatory process was investigated. PROCEDURES: Using a collagen-induced experimental rat model of rheumatoid arthritis, in vivo imaging using the PET tracers [(11)C]PK11195, which binds to the translocator protein mainly expressed on myeloid cells, and [(11)C]ketoprofen, for cyclooxygenase imaging, was performed...
January 3, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/27992691/a-multi-biomarker-disease-activity-score-and-the-choice-of-second-line-therapy-in-early-rheumatoid-arthritis-after-methotrexate-failure
#2
Karen Hambardzumyan, Saedis Saevarsdottir, Kristina Forslind, Ingemar F Petersson, Johan K Wallman, Sofia Ernestam, Rebecca J Bolce, Ronald F van Vollenhoven
OBJECTIVE: We investigated whether the multi-biomarker disease activity (MBDA) score predicts optimal add-on treatment in methotrexate-inadequate-responders (MTX-IR) in early rheumatoid arthritis (RA). METHODS: We analysed 157 MTX-IRs (28-joint disease activity score based on erythrocyte sedimentation rate [DAS28-ESR] >3.2) from the Swedish Farmacotherapy (SWEFOT) trial who were randomized to triple therapy (TT [MTX+sulfasalazine+hydroxychloroquine]) versus MTX+infliximab...
December 19, 2016: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/27992656/meta-regression-of-a-dose-response-relationship-of-methotrexate-in-mono-and-combination-therapy-in-dmard-naive-early-rheumatoid-arthritis-patients
#3
S A Bergstra, C F Allaart, T Stijnen, Rbm Landewé
OBJECTIVE: To investigate a possible short term dose-response relationship of initial treatment with methotrexate in monotherapy and combination therapy in recent onset rheumatoid arthritis (RA) patients. METHODS: A systematic literature search was performed on trials and cohorts including early, Disease Modifying Antirheumatic Drugs (DMARD) naive RA patients, treated with methotrexate, with data on clinical results within 6 months from treatment start. Cohen's effect sizes were calculated for the HAQ, ESR/CRP and/or DAS/DAS28 in 4 treatment groups: methotrexate monotherapy, or methotrexate in combination with synthetic (cs)DMARDs, biologic (b)DMARDs or glucocorticoids...
December 19, 2016: Arthritis Care & Research
https://www.readbyqxmd.com/read/27992368/early-detection-of-rheumatoid-arthritis-in-rats-and-humans-with-99mtc-3prgd2-scintigraphy-imaging-synovial-neoangiogenesis
#4
Yu Wu, Guojian Zhang, Xiangcheng Wang, Zhenfang Zhao, Tao Wang, Xuemei Wang, Xiao-Feng Li
OBJECTIVES: To validate 99mTc-labeled arginylglycylaspartic acid (99mTc-3PRGD2) scintigraphy as a means to image synovial neoangiogenesis in joints afflicted by rheumatoid arthritis and to investigate its potential in the early detection and management of rheumatoid arthritis. METHODS: Rheumatoid arthritis and osteoarthritis were generated in Sprague Dawley rats by type II collagen immunization and papain injection, respectively. Rats were imaged with 99mTc-3PRGD2 and 99mTc- methyl diphosphonate (99mTc MDP)...
December 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27989589/efficacy-of-triple-association-methotrexate-sulfasalazine-and-hydroxychloroquine-in-early-treatment-of-rheumatoid-arthritis-with-insufficient-response-to-methotrexate-meta-analysis-of-randomized-controlled-trials
#5
Arnaud Mazouyès, Marine Clay, Anne-Catherine Bernard, Philippe Gaudin, Athan Baillet
OBJECTIVES: To evaluate the efficacy of the triple synthetic Disease Modifying Anti-Rheumatic Drugs (sDMARD) combination methotrexate, sulfasalazine and hydroxychloroquine versus a biologic DMARD (bDMARD) in the treatment of early rheumatoid arthritis. METHODS: A systematic literature search was performed using the PubMed and Cochrane databases, and abstracts presented at rheumatology scientific meetings until December 2013. Randomized controlled trials comparing the efficacy and the safety of biologic DMARD with the triple combination were included...
December 15, 2016: Joint, Bone, Spine: Revue du Rhumatisme
https://www.readbyqxmd.com/read/27964757/discordant-inflammation-and-pain-in-early-and-established-rheumatoid-arthritis-latent-class-analysis-of-early-rheumatoid-arthritis-network-and-british-society-for-rheumatology-biologics-register-data
#6
Daniel F McWilliams, Eamonn Ferguson, Adam Young, Patrick D W Kiely, David A Walsh
BACKGROUND: Rheumatoid arthritis (RA) disease activity is often measured using the 28-joint Disease Activity Score (DAS28). We aimed to identify and independently verify subgroups of people with RA that may be discordant with respect to self-reported and objective disease state, with potentially different clinical needs. METHODS: Data were derived from three cohorts: (1) the Early Rheumatoid Arthritis Network (ERAN) and the British Society for Rheumatology Biologics Register (BSRBR), (2) those commencing tumour necrosis factor (TNF)-α inhibitors and (3) those using non-biologic drugs...
December 13, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27943044/anti-mcv-antibodies-predict-radiographic-progression-in-greek-patients-with-very-early-3%C3%A2-months-duration-rheumatoid-arthritis
#7
Georgia Barouta, Christina G Katsiari, Ioannis Alexiou, Christos Liaskos, Areti Varna, Dimitrios P Bogdanos, Anastasios E Germenis, Lazaros I Sakkas
This study aimed to assess the diagnostic and prognostic value of anti-mutated citrullinated vimentin (MCV) antibodies in very early rheumatoid arthritis (VERA) and in established rheumatoid arthritis (RA). Seventy-one patients with undifferentiated arthritis (UA) of <3 months duration, 141 with established RA, 53 with other rheumatic diseases, and 40 healthy individuals were included in the study. Anti-MCV, anti-cyclic citrullinated peptide (CCP) antibodies, and rheumatoid factor (RF) were determined and hand radiographs were recorded...
December 10, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27921185/hand-bone-loss-in-early-rheumatoid-arthritis-during-a-methotrexate-based-treat-to-target-strategy-with-or-without-adalimumab-a-substudy-of-the-optimized-treatment-algorithm-in-early-ra-opera-trial
#8
L M Ørnbjerg, M Østergaard, T Jensen, K Hørslev-Petersen, K Stengaard-Pedersen, P Junker, T Ellingsen, P Ahlquist, H Lindegaard, A Linauskas, A Schlemmer, M Y Dam, I Hansen, T Lottenburger, C G Ammitzbøll, A Jørgensen, S B Krintel, J Raun, M L Hetland, Ole Slot, Lars Kjær Nielsen, Henrik Skjødt, Ole Majgaard, Tove Lorenzen, Hans Christian Horn, Marcin Kowalski, Inger Lauge Johansen, Peter Mosborg Pedersen, Natalia Manilo, Henning Bliddal
This study aims to investigate 1-year hand bone loss (HBL1-year) in early rheumatoid arthritis (RA) patients treated with a methotrexate (MTX) and intra-articular triamcinolone treat-to-target strategy +/- adalimumab and to determine if HBL6months is associated with radiographic progression after 2 years. In a clinical trial (OPERA) of 180 treatment-naive early RA patients, bone mineral density (BMD) was estimated from hand radiographs with digital X-ray radiogrammetry (DXR) at baseline, after 6 (n = 90) and 12 months (n = 70) of follow-up...
December 5, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27909140/longterm-work-productivity-costs-due-to-absenteeism-and-permanent-work-disability-in-patients-with-early-rheumatoid-arthritis-a-nationwide-register-study-of-7831-patients
#9
Janne A Martikainen, Hannu Kautiainen, Vappu Rantalaiho, Kari T Puolakka
OBJECTIVE: To estimate the development and potential disproportional distribution of longterm productivity costs (PC) and their determinants leading to work absenteeism and permanent work disability in working-aged patients with early rheumatoid arthritis (RA). METHODS: A cohort of subjects with early RA was created by identifying the new cases of RA from the national drug reimbursement register that had been granted a special reimbursement for their antirheumatic medications for RA from 2000-2007...
December 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27885849/dna-methylation-at-diagnosis-is-associated-with-response-to-disease-modifying-drugs-in-early-rheumatoid-arthritis
#10
John R Glossop, Nicola B Nixon, Richard D Emes, Julius Sim, Jon C Packham, Derek L Mattey, William E Farrell, Anthony A Fryer
AIM: A proof-of-concept study to explore whether DNA methylation at first diagnosis is associated with response to disease-modifying antirheumatic drugs (DMARDs) in patients with early rheumatoid arthritis (RA). PATIENTS & METHODS: DNA methylation was quantified in T-lymphocytes from 46 treatment-naive patients using HumanMethylation450 BeadChips. Treatment response was determined in 6 months using the European League Against Rheumatism (EULAR) response criteria...
November 25, 2016: Epigenomics
https://www.readbyqxmd.com/read/27882112/diagnostic-value-of-high-frequency-ultrasound-and-magnetic-resonance-imaging-in-early-rheumatoid-arthritis
#11
Ming-Yu Wang, Xian-Bin Wang, Xue-Hui Sun, Feng-Li Liu, Sheng-Chuan Huang
Early diagnosis and management improve the outcome of patients with rheumatoid arthritis (RA). The present study explored the application of high-frequency ultrasound (US) and magnetic resonance imaging (MRI) in the detection of early RA. Thirty-nine patients (20 males and 19 females) diagnosed with early RA were enrolled in the study. A total of 1,248 positions, including 858 hand joints and 390 tendons, were examined by high-frequency US and MRI to evaluate the presence of bone erosion, bone marrow edema (BME), synovial proliferation, joint effusion, tendinitis and tendon sheath edema...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27855721/the-lung-microbiota-in-early-rheumatoid-arthritis-and-autoimmunity
#12
Jose U Scher, Vijay Joshua, Alejandro Artacho, Shahla Abdollahi-Roodsaz, Johan Öckinger, Susanna Kullberg, Magnus Sköld, Anders Eklund, Johan Grunewald, Jose C Clemente, Carles Ubeda, Leopoldo N Segal, Anca I Catrina
BACKGROUND: Airway abnormalities and lung tissue citrullination are found in both rheumatoid arthritis (RA) patients and individuals at-risk for disease development. This suggests the possibility that the lung could be a site of autoimmunity generation in RA, perhaps in response to microbiota changes. We therefore sought to test whether the RA lung microbiome contains distinct taxonomic features associated with local and/or systemic autoimmunity. METHODS: 16S rRNA gene high-throughput sequencing was utilized to compare the bacterial community composition of bronchoalveolar lavage fluid (BAL) in patients with early, disease-modifying anti-rheumatic drugs (DMARD)-naïve RA, patients with lung sarcoidosis, and healthy control subjects...
November 17, 2016: Microbiome
https://www.readbyqxmd.com/read/27855453/-no-benefit-from-an-ultrasound-tight-control-strategy-in-patients-with-early-rheumatoid-arthritis
#13
Sarah Ohrndorf
No abstract text is available yet for this article.
November 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27845285/-clinical-significance-of-biomarkers-of-osteochondral-lesions-in-early-rheumatoid-arthritis
#14
D Rekalov
The aim of the research was to study biomarkers of osteochondral lesions on early stages of rheumatoid arthritis (RA). The data showed the prognostic value of indicators of the erosive and destructive changes of joints in early and in the advanced stage of RA. Indicators that determine how directly, inflammatory process activity and markers associated with the speed and staging damage of articular surfaces is analyzed. That can adequately justify individualized clinical strategy in patients with early RA.
October 2016: Georgian Medical News
https://www.readbyqxmd.com/read/27832385/non-medical-costs-during-the-first-year-after-diagnosis-in-two-cohorts-of-patients-with-early-rheumatoid-arthritis-enrolled-10%C3%A2-years-apart
#15
Magnus Husberg, Thomas Davidson, Eva Hallert
The aim of the present study was to calculate non-medical costs during year 1 after diagnosis in two cohorts of patients with early rheumatoid arthritis enrolled 1996-1998 and 2006-2009. Clinical data were collected regularly in both cohorts. Besides information about healthcare utilization and days lost from work, patients reported non-medical costs for aids/devices, transportation, formal and informal care. Formal care was valued as full labour cost for official home help (€42.80/h) and informal care from relatives and friends as opportunity cost of leisure time, corresponding to 35% of labour cost (€15/h)...
November 10, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27830970/assessment-of-both-articular-synovitis-and-tenosynovitis-by-ultrasound-is-useful-for-evaluations-of-hand-dysfunction-in-early-rheumatoid-arthritis-patients
#16
Ayako Nishino, Shin-Ya Kawashiri, Toshimasa Shimizu, Masataka Umeda, Shoichi Fukui, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Yasuhiro Nagata, Takahiro Maeda, Kiyoshi Aoyagi, Atsushi Kawakami
OBJECTIVES: We investigated the association between hand dysfunction and ultrasound (US)-detected articular synovitis and tenosynovitis in patients with rheumatoid arthritis (RA). METHODS: Thirty RA patients were examined. In both hands of all subjects, articular synovitis and tenosynovitis were assessed by US at 22 joints and 12 tendons. Each joint and tendon was scored by gray-scale (GS) and power Doppler (PD) on a scale from 0 to 3. The sums of the GS or PD scores were used as the articular synovitis score and the tenosynovitis score...
November 15, 2016: Modern Rheumatology
https://www.readbyqxmd.com/read/27829394/the-scottish-early-rheumatoid-arthritis-sera-study-an-inception-cohort-and-biobank
#17
James Dale, Caron Paterson, Ann Tierney, Stuart H Ralston, David M Reid, Neil Basu, John Harvie, Neil D McKay, Sarah Saunders, Hilary Wilson, Robin Munro, Ruth Richmond, Derek Baxter, Michael McMahon, John McLaren, Vinod Kumar, Stefan Siebert, Iain McInnes, Duncan Porter
The Scottish Early Rheumatoid Arthritis (SERA) study is an inception cohort of rheumatoid (RA) and undifferentiated arthritis (UA) patients that aims to provide a contemporary description of phenotype and outcome and facilitate discovery of phenotypic and prognostic biomarkers METHODS: Demographic and clinical outcome data are collected from newly diagnosed RA/UA patients every 6 months from around Scotland. Health service utilization data is acquired from Information Services Division, NHS National Services Scotland...
November 9, 2016: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/27805330/diagnostic-accuracy-of-ultrasonography-in-detection-of-destructive-changes-in-small-joints-of-hands-in-patients-of-rheumatoid-arthritis-a-comparison-with-magnetic-resonance-imaging
#18
Sonal Saran, Meenu Bagarhatta, Renu Saigal
BACKGROUND: Ultrasonography can be used in early Rheumatoid Arthritis to determine and to follow parameters of joint inflammation, such as effusion, synovitis, and marginal erosion that can be radiologically occult. We therefore planned a study to investigate whether Ultrasonography could provide information on signs of inflammation and destruction in Rheumatoid Arthritis affected finger joints that was not available with Radiography and compared it to the information provided by Magnetic resonance imaging...
November 2016: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/27778096/the-dimeric-form-of-hla-g-molecule-is-associated-with-the-response-of-early-rheumatoid-arthritis-era-patients-to-methotrexate
#19
Roberta Rizzo, Ilaria Farina, Daria Bortolotti, Elisa Galuppi, Melissa Padovan, Dario Di Luca, Marcello Govoni
A growing body of evidence indicates a possible involvement of HLA (human leukocyte antigen)-G antigens in rheumatoid arthritis (RA), mainly in the HLA-G dimeric isoform, the most active HLA-G form with the strongest immunosuppression, that showed an excellent anti-inflammatory effect in collagen-induced arthritis model mice. However, the relevance of HLA-G dimers in RA response to methotrexate (MTX) treatment is still unknown. We analyzed the HLA-G dimers' amount in plasma samples from early rheumatoid arthritis (ERA) patients before MTX therapy and evaluated the role of these molecules as biomarker of the different response to the treatment...
October 24, 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/27775461/effect-of-a-treat-to-target-cyclosporin-on-mri-assessed-synovitis-osteitis-tenosynovitis-bone-erosion-and-joint-space-narrowing-in-early-rheumatoid-arthritis-results-from-a-2-year-randomized-double-blind
#20
S Møller-Bisgaard, B J Ejbjerg, I Eshed, K Hørslev-Petersen, M L Hetland, A G Jurik, H Thomsen, T Torfing, K Stengaard-Pedersen, P Junker, N S Krogh, T Lottenburger, T Ellingsen, L S Andersen, H Skjødt, A J Svendsen, U Tarp, I T Hansen, J Pødenphant, J K Pedersen, H Lindegaard, L G Hanson, A Vestergaard, D Glinatsi, M Østergaard
OBJECTIVES: To investigate whether a treat-to-target strategy based on methotrexate (MTX) and intra-articular (IA) betamethasone suppresses magnetic resonance imaging (MRI)-determined measures of disease activity and reduces joint destruction in early rheumatoid arthritis (eRA) patients, and to investigate whether concomitant cyclosporin A (CyA) provides an additional effect. METHOD: In the 2-year randomized, double-blind, treat-to-target trial CIMESTRA, 160 patients with eRA (< 6 months) were randomized to MTX, intra-articular betamethasone and CyA, or placebo CyA...
October 24, 2016: Scandinavian Journal of Rheumatology
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