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https://www.readbyqxmd.com/read/29684902/effect-of-lipopeptide-structure-on-gene-delivery-system-properties-evaluation-in-2d-and-3d-in-vitro-models
#1
O O Koloskova, A M Gileva, M G Drozdova, M V Grechihina, N E Suzina, U A Budanova, Yu L Sebyakin, D A Kudlay, I P Shilovskiy, A M Sapozhnikov, E I Kovalenko, E A Markvicheva, M R Khaitov
Development of efficient biodegradable, environmentally responsive, biocompatible and non-toxic delivery system is needed for efficient gene delivery. As well known, properties of the vehicle are determined by the structure of carrier components. The aim of the current study was to estimate in vitro transfection efficacy of aliphatic di-, tri- and tetrapeptide-based cationic lipoplexes loaded with siRNA in function of a number of cationic groups using 2D (monolayer culture) and 3D (multicellular tumor spheroids) in vitro models...
April 7, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29684860/polyphenol-rich-extract-of-ocimum-gratissimum-leaves-ameliorates-colitis-via-attenuating-colonic-mucosa-injury-and-regulating-pro-inflammatory-cytokines-production-and-oxidative-stress
#2
Quadri K Alabi, Rufus O Akomolafe, Joseph G Omole, Modinat A Adefisayo, Olaofe L Ogundipe, Ayodeji Aturamu, Joseph O Sanya
Colitis is a chronic inflammation and ulcer on the inner lining of the large intestine. For many centuries Ocimum gratissimum (OG) leaves have been used in folk medicine in Nigeria to treat inflammatory bowel diseases, however, to date, the anti-colitis effects of OG have not been scientifically proven. In this study we investigated the effects of polyphenol rich extract of Ocimum gratissimum (PREOG) leaf on colonic mucosa injury in colitis, its mechanisms, initial administration time and dosage. Dextran sodium sulfate (DSS)-induced rat colitis models was used...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684694/microplastics-in-different-tissues-of-fish-and-prawn-from-the-musa-estuary-persian-gulf
#3
Sajjad Abbasi, Naghmeh Soltani, Behnam Keshavarzi, Farid Moore, Andrew Turner, Mina Hassanaghaei
Commercially-important species of fish and a crustacean from four sites in the Musa estuary and a site in the Persian Gulf have been analysed for the presence and location of microplastics (MPs). A total of 828 MPs were detected in the guts (gastrointestinal tracts), skin, muscle, gills and liver of demersal and pelagic fish (Platycephalus indicus, Saurida tumbil, Sillago sihama, Cynoglossus abbreviatus) from all five sites and in the exoskeleton and muscle of the tiger prawn, Penaeus semisulcatus, from three sites...
April 18, 2018: Chemosphere
https://www.readbyqxmd.com/read/29684689/is-the-chlorophyll-derivative-zn-ii-e-6-me-a-good-photosensitizer-to-be-used-in-root-canal-disinfection
#4
P Diogo, M Mota, C Fernandes, D Sequeira, P Palma, F Caramelo, M G P M S Neves, M A F Faustino, T Gonçalves, J M Santos
BACKGROUND: The aim of this study was to assess antimicrobial efficacy and cytotoxic outcomes of a chlorophyll based photosensitizer (PS) Zn(II)chlorin e6 methyl ester (Zn(II)e6 Me), when applied to human dentin discs and root blocks infected with 48 h biofilms. The results were compared with the ones obtained with FotoSan® (commercial Toluidine Blue O formulation) and 3% sodium hypochlorite (NaOCl). METHODOLOGY: Dentin and root blocks were infected with mixed biofilms of Enterococcus faecalis and Candida albicans; exposed for 15 min to 0...
April 20, 2018: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29684602/trans-cinnamic-acid-application-for-rainbow-trout-oncorhynchus-mykiss-i-effects-on-haematological-serum-biochemical-non-specific-immune-and-head-kidney-gene-expression-responses
#5
Sevdan Yilmaz, Sebahattin Ergün
The present study investigated the effects of dietary trans-cinnamic acid (CA) on pre- and post-challenge haematological, serum biochemical, non-specific immune and head kidney gene expression responses of rainbow trout, Oncorhynchus mykiss juveniles. In this regard, fish with an average weight of 17.01 ± 0.05 g were divided into five groups, and fed daily with an additive free basal diet (control); 250, 500, 750 or 1500 mg kg-1  CA for a 60-day period. Fish were sampled every 20 days during the experiment...
April 20, 2018: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29684590/a-synthetic-snake-venom-based-tripeptide-glu-val-trp-protects-pc12-cells-from-mpp-toxicity-by-activating-the-ngf-signaling-pathway
#6
Carolina P Bernardes, Neife A G Santos, Flavia M Sisti, Rafaela Scalco Ferreira, Norival A Santos-Filho, Adélia C O Cintra, Eduardo M Cilli, Suely V Sampaio, Antonio C Santos
Venom small peptides that target neurotrophin receptors might be beneficial in neurodegeneration, including Parkinsońs disease (PD). Their small size, ease of synthesis, structural stability and target selectivity make them important tools to overcome the limitations of endogenous neurotrophins as therapeutic agents. Additionally, they might be optimized to improve resistance to enzymatic degradation, bioavailability, potency and, mainly, lipophilicity, important to cross the blood brain barrier (BBB). Here, we evaluated the neuroprotective effects and mechanisms of the synthetic snake-venom-based peptide p-BTX-I (Glu-Val-Trp) in PC12 cells treated with MPP+ (1-methyl-4-phenylpyridinium), a dopaminergic neurotoxin that induces Parkinsonism in vivo...
April 20, 2018: Peptides
https://www.readbyqxmd.com/read/29684213/low-thyroid-function-is-not-associated-with-an-accelerated-deterioration-in-renal-function
#7
Christiaan L Meuwese, Merel van Diepen, Anne R Cappola, Mark J Sarnak, Michael G Shlipak, Douglas C Bauer, Linda P Fried, Massimo Iacoviello, Bert Vaes, Jean Degryse, Kay-Tee Khaw, Robert N Luben, Bjørn O Åsvold, Trine Bjøro, Lars J Vatten, Anton J M de Craen, Stella Trompet, Giorgio Iervasi, Sabrina Molinaro, Graziano Ceresini, Luigi Ferrucci, Robin P F Dullaart, Stephan J L Bakker, J Wouter Jukema, Patricia M Kearney, David J Stott, Robin P Peeters, Oscar H Franco, Henry Völzke, John P Walsh, Alexandra Bremner, José A Sgarbi, Rui M B Maciel, Misa Imaizumi, Waka Ohishi, Friedo W Dekker, Nicolas Rodondi, Jacobijn Gussekloo, Wendy P J den Elzen
Background: Chronic kidney disease (CKD) is frequently accompanied by thyroid hormone dysfunction. It is currently unclear whether these alterations are the cause or consequence of CKD. This study aimed at studying the effect of thyroid hormone alterations on renal function in cross-sectional and longitudinal analyses in individuals from all adult age groups. Methods: Individual participant data (IPD) from 16 independent cohorts having measured thyroid stimulating hormone, free thyroxine levels and creatinine levels were included...
April 18, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29684200/ultrasound-for-assessing-disease-activity-in-ibd-patients-a-systematic-review-of-activity-scores
#8
S Bots, K Nylund, M Löwenberg, K Gecse, O H Gilja, G D'Haens
Background and aims: Ultrasound (US) indices for assessing disease activity in IBD patients have never been critically reviewed. We aimed to systematically review the quality and reliability of available ultrasound (US) indices compared with reference standards for grading disease activity in IBD patients. Methods: Pubmed, Embase and Medline were searched from 1990 until June 2017. Relevant publications were identified through full text review after initial screening by 2 investigators...
April 19, 2018: Journal of Crohn's & Colitis
https://www.readbyqxmd.com/read/29684147/plasma-and-csf-pharmacokinetics-of-meropenem-in-neonates-and-young-infants-results-from-the-neomero-studies
#9
Eva Germovsek, Irja Lutsar, Karin Kipper, Mats O Karlsson, Tim Planche, Corine Chazallon, Laurence Meyer, Ursula M T Trafojer, Tuuli Metsvaht, Isabelle Fournier, Mike Sharland, Paul Heath, Joseph F Standing
Background: Sepsis and bacterial meningitis are major causes of mortality and morbidity in neonates and infants. Meropenem, a broad-spectrum antibiotic, is not licensed for use in neonates and infants below 3 months of age and sufficient information on its plasma and CSF disposition and dosing in neonates and infants is lacking. Objectives: To determine plasma and CSF pharmacokinetics of meropenem in neonates and young infants and the link between pharmacokinetics and clinical outcomes in babies with late-onset sepsis (LOS)...
April 19, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29683914/different-patterns-in-muscular-strength-and-hypertrophy-adaptations-in-untrained-individuals-undergoing-nonperiodized-and-periodized-strength-regimens
#10
Eduardo O De Souza, Valmor Tricoli, Jacob Rauch, Michael R Alvarez, Gilberto Laurentino, André Y Aihara, Fabiano N Cardoso, Hamilton Roschel, Carlos Ugrinowitsch
De Souza, EO, Tricoli, V, Rauch, J, Alvarez, MR, Laurentino, G, Aihara, AY, Cardoso, FN, Roschel, H, and Ugrinowitsch, C. Different patterns in muscular strength and hypertrophy adaptations in untrained individuals undergoing non-periodized and periodized strength regimens. J Strength Cond Res 32(5): 1238-1244, 2018-This study investigated the effects of nonperiodized (NP), traditional periodization (TP), and daily undulating periodization (UP) regimens on muscle strength and hypertrophy in untrained individuals...
May 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29683888/transfusion-rates-and-the-utility-of-type-and-screen-for-pelvic-organ-prolapse-surgery
#11
Taylor J Brueseke, Maggie F Wilkins, Marcella G Willis-Gray, Katherine E Husk, Alexis R Peedin, Elizabeth J Geller, Jennifer M Wu
OBJECTIVES: Limited data exist directly comparing the likelihood of blood transfusion by route of apical pelvic organ prolapse (POP) surgery. In addition, limited evidence is available regarding the risk of not ordering preoperative type and screen (T&S) in apical POP surgery. The objectives of the study are to (1) provide baseline data regarding the current need for preoperative T&S by comparing perioperative blood transfusion rates between 3 routes of apical POP surgery and (2) determine the rate of a positive preoperative antibody screen in women who underwent apical POP surgery...
April 20, 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29683668/blue-and-red-shifting-hydrogen-bonding-a-gas-phase-ftir-and-ab-initio-study-of-rr-co%C3%A2-%C3%A2-%C3%A2-dccl-3-and-rr-s%C3%A2-%C3%A2-%C3%A2-dccl-3-complexes
#12
Bedabyas Behera, Puspendu Kumar Das
Blue shifting H-bonded (C-D···O) complexes between CDCl3 and CH3HCO, (CH3)2CO, C2H5(CH3)CO and red shifting H-bonded (C-D···S) complexes between CDCl3 with (CH3)2S, (C2H5)2S have been identified by FTIR spectroscopy in gas phase at room temperature. With increasing partial pressure of the components, a new band appears in the C-D stretching region of the vibrational spectra. The intensity of this band goes down with increase in temperature at constant pressure which provides the basis for identification of the H-bonded bands in the spectrum...
April 23, 2018: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29683471/comprehensive-high-resolution-genomic-profiling-and-cytogenetics-of-human-chondrocyte-cultures-by-gtg-banding-locus-specific-fish-sky-and-snp-array
#13
M Wallenborn, O Petters, D Rudolf, H Hantmann, M Richter, P Ahnert, L Rohani, J J Smink, G C Bulwin, W Krupp, R M Schulz, H Holland
In the development of cell-based medicinal products, it is crucial to guarantee that the application of such an advanced therapy medicinal product (ATMP) is safe for the patients. The consensus of the European regulatory authorities is: "In conclusion, on the basis of the state of art, conventional karyotyping can be considered a valuable and useful technique to analyse chromosomal stability during preclinical studies". 408 chondrocyte samples (84 monolayers and 324 spheroids) from six patients were analysed using trypsin-Giemsa staining, spectral karyotyping and fluorescence in situ hybridisation, to evaluate the genetic stability of an ATMP named Spherox®...
April 23, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29683342/guttiferone-bl-with-antibacterial-activity-from-the-fruits-of-allanblackia-gabonensis
#14
Blaise Kemajou Nganou, Ingrid Simo Konga, Aimé G Fankam, Gabin Thierry M Bitchagno, Gaielle Sonfack, Paul Nayim, Ilhami Celik, Sema Koyutürk, Victor Kuete, Pierre Tane
Allanblackia genus, an endless source of bioactive compounds, was investigated for its antibacterial properties. The chemical study of the methanol extract from the fruits of Allanblackia gabonensis resulted in the isolation of the undescribed guttiferone BL (1) along with the known kaempferol (2), morelloflavone (3), morelloflavone 7″-O-β-D-glucopyranoside (4), β-sitosterol 3-O-β-D-glucopyranoside and β-sitosterol. Their structures were determined using spectrometry and spectroscopic techniques. The antibacterial activity was evaluated against five Gram-negative and two Gram-positive strains using a broth micro-dilution method...
April 23, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29682875/photochemical-generation-of-chiral-n-b-x-heterocycles-via-heteroaromatic-c-x-bond-scission-x-s-o-and-boron-insertion
#15
Soren K Mellerup, Cally Li, Julian Radtke, Xiang Wang, Quan-Song Li, Suning Wang
Chiral organoboron compounds with a chelate backbone and mesityl/heterocycle substituents on boron (thienyl, furyl and derivatives) undergo a quantitative phototransformation yielding rare, chiral N,B,X-embedded heterocycles (b) (e.g. base-stabilized 1,2-thiaborinines and 1,2-oxaborinines). Boriranes (a) were observed as intermediates in some of these transformations. Oxaborinines display further photoreactivity, generating 4a,12b-dihydro-benzo[h][1,2]-oxaborinino-[4,3-f]quinolones through a sequential conrotatory electrocyclization and [1,5]-H shift...
April 23, 2018: Angewandte Chemie
https://www.readbyqxmd.com/read/29682598/cycloid-scanning-for-wide-field-optical-coherence-tomography-endomicroscopy-and-angiography-in-vivo
#16
Kaicheng Liang, Zhao Wang, Osman O Ahsen, Hsiang-Chieh Lee, Benjamin M Potsaid, Vijaysekhar Jayaraman, Alex Cable, Hiroshi Mashimo, Xingde Li, James G Fujimoto
Devices that perform wide field-of-view (FOV) precision optical scanning are important for endoscopic assessment and diagnosis of luminal organ disease such as in gastroenterology. Optical scanning for in vivo endoscopic imaging has traditionally relied on one or more proximal mechanical actuators, limiting scan accuracy and imaging speed. There is a need for rapid and precise two-dimensional (2D) microscanning technologies to enable the translation of benchtop scanning microscopies to in vivo endoscopic imaging...
January 20, 2018: Optica
https://www.readbyqxmd.com/read/29682379/extensor-tendons-rupture-after-volar-plating-of-distal-radius-fracture-related-to-a-dorsal-radial-metaphyseal-bone-spur
#17
M O Abrego, F L De Cicco, J G Boretto, G L Gallucci, P De Carli
Extensor tendon ruptures due to volar plating in distal radius fractures have mostly been described in relation with technique failures such as screw prominence and drill penetration. We report the case of a 71-year-old female with a C2 distal radius fracture with severe dorsal metaphyseal comminution. The patient underwent surgical treatment with reduction of the large fragments and fixation with a volar locking plate; the small dorsal metaphyseal nonarticular fragments were not reduced. Six months later, the patient developed extensor digitorum communis (EDC) rupture and extensor indicis proprius (EIP) laceration in coincidence with the dorsal comminution turned into a bony spur...
2018: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29682166/ros-induced-dna-damage-associates-with-abundance-of-mitochondrial-dna-in-white-blood-cells-of-the-untreated-schizophrenic-patients
#18
I V Chestkov, E M Jestkova, E S Ershova, V G Golimbet, T V Lezheiko, N Yu Kolesina, O A Dolgikh, V L Izhevskaya, G P Kostyuk, S I Kutsev, N N Veiko, S V Kostyuk
Objective: The aim of this study was (1) to examine the leukocyte mtDNA copy number ( CN ) in unmedicated (SZ (m-)) and medicated (SZ (m+)) male patients with paranoid schizophrenia (SZ) in comparison with the healthy male controls (HC) and (2) to compare the leukocyte mtDNA CN with the content of an oxidation marker 8-oxodG in lymphocytes of the SZ (m-) patients. Methods: We evaluated leukocyte mtDNA CN of 110 subjects with SZ in comparison with 60 male HC by the method qPCR (ratio mtDNA/nDNA (gene B2M) was detected)...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29682164/defective-autophagy-in-atherosclerosis-to-die-or-to-senesce
#19
REVIEW
Mandy O J Grootaert, Lynn Roth, Dorien M Schrijvers, Guido R Y De Meyer, Wim Martinet
Autophagy is a subcellular process that plays an important role in the degradation of proteins and damaged organelles such as mitochondria (a process termed "mitophagy") via lysosomes. It is crucial for regulating protein and mitochondrial quality control and maintaining cellular homeostasis, whereas dysregulation of autophagy has been implicated in a wide range of diseases including atherosclerosis. Recent evidence has shown that the autophagic process becomes dysfunctional during the progression of atherosclerosis, regardless of whether there are many autophagy-stimulating factors (e...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29681665/estimating-wetland-connectivity-to-streams-in-the-prairie-pothole-region-an-isotopic-and-remote-sensing-approach
#20
J R Brooks, D M Mushet, M K Vanderhoof, S G Leibowitz, J R Christensen, B P Neff, D O Rosenberry, W D Rugh, L C Alexander
Understanding hydrologic connectivity between wetlands and perennial streams is critical to understanding the reliance of stream flow on inputs from wetlands. We used the isotopic evaporation signal in water and remote sensing to examine wetland-stream hydrologic connectivity within the Pipestem Creek watershed, North Dakota, a watershed dominated by prairie-pothole wetlands. Pipestem Creek exhibited an evaporated-water signal that had approximately half the isotopic-enrichment signal found in most evaporatively enriched prairie-pothole wetlands...
March 9, 2018: Water Resources Research
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