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https://www.readbyqxmd.com/read/28096867/nasal-nosocomial-myiasis-infection-caused-by-chrysomya-bezziana-diptera-calliphoridae-following-the-septicemia-a-case-report
#1
Seyed Farzin Mircheraghi, Seyed Farzam Mircheraghi, Hamed Ramezani Awal Riabi, Arezoo Parsapour
A 74 yr old woman from Gonabad, southern part of Khorasan Razavi Province of Iran was admitted to a Hospital of Gonabad, because of respiratory distress, exertional dyspnea and fever. Close contact with domestic animals, history of chronic obstructive pulmonary disease (COPD), and completely resolved pulmonary tuberculosis (TB) in remote past, were notable parts of her past medical history. Due to clinical, paraclinical and radiographic findings and because of recent hospitalization, she was admitted to internal medicine ward with the diagnosis of health care associated pneumonia (HCAP)...
April 2016: Iranian Journal of Parasitology
https://www.readbyqxmd.com/read/28094205/legionnaires-disease-at-a-medical-center-in-southern-taiwan
#2
Tzu-Lun Hung, Ming-Chi Li, Li-Rong Wang, Ching-Chuan Liu, Chia-Wen Li, Po-Lin Chen, Ling-Shan Syue, Nan-Yao Lee, Wen-Chien Ko
BACKGROUND/PURPOSE: Legionella pneumophila had been recognized as a pathogen for both healthcare-associated and community-acquired pneumonia. We aimed to evaluate clinical features and outcomes of patients with Legionnaires' disease at a tertiary medical center in southern Taiwan. METHODS: From January 2005 to December 2013, a retrospective study of adult cases of Legionnaires' disease was conducted in a 1200-bed tertiary hospital. Their medical records were reviewed for further evaluation and analysis...
December 18, 2016: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28069814/muc2-mucin-and-butyrate-contribute-to-the-synthesis-of-the-antimicrobial-peptide-cathelicidin-in-response-to-e-histolytica-and-dss-induced-colitis
#3
Eduardo R Cobo, Vanessa Kissoon-Singh, France Moreau, Ravi Holani, Kris Chadee
Embedded in the colonic mucus are cathelicidins, small cationic peptides secreted by colonic epithelial cells. Humans and mice have one cathelicidin-related antimicrobial peptide (CRAMP), LL-37/hCAP-18 and Cramp respectively, with related structure and functions. Altered production of MUC2 mucin and antimicrobial peptides is characteristic of intestinal amebiasis. The interactions between MUC2 mucin and cathelicidins in conferring innate immunity against Entamoeba histolytica (Eh) are not well characterized...
January 9, 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28006672/gene-electrotransfer-into-skin-using-noninvasive-multi-electrode-array-for-vaccination-and-wound-healing
#4
Spela Kos, Kevin Vanvarenberg, Tanja Dolinsek, Maja Cemazar, Jure Jelenc, Véronique Préat, Gregor Sersa, Gaëlle Vandermeulen
Skin is an attractive target for gene electrotransfer due to its easy accessibility and its interesting immune properties. Since electrodes are often invasive and frequently induce discomfort during pulse application, there is a fundamental need for non-invasive electrodes for skin delivery. We developed circular pin non-invasive multi-electrode array (MEA), suitable for different clinical applications. MEA was first employed to deliver a luciferase reporter gene. Then, it was used to deliver a DNA vaccine coding for ovalbumin or a plasmid encoding hCAP-18/LL-37 for promoting wound healing...
December 10, 2016: Bioelectrochemistry
https://www.readbyqxmd.com/read/27943383/statin-potency-and-the-risk-of-hospitalization-for-community-acquired-pneumonia
#5
Ju-Young Shin, Maria Eberg, Pierre Ernst, Kristian B Filion
AIM: Previous studies suggest that statins may have beneficial respiratory effects. However, it is unclear if these purported benefits vary with statin potency. Our objective was to determine if higher potency statins, compared with lower potency statins, were associated with a reduced risk of hospitalization for community-acquired pneumonia (HCAP). METHODS: We conducted a nested case-control analysis of a retrospective, population-based cohort of new users of statins using data extracted from the United Kingdom's Clinical Practice Research Datalink and Hospital Episode Statistics...
December 9, 2016: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/27827962/cholecalciferol-additively-reduces-serum-parathyroid-hormone-and-increases-vitamin-d-and-cathelicidin-levels-in-paricalcitol-treated-secondary-hyperparathyroid-hemodialysis-patients
#6
Jing-Quan Zheng, Yi-Chou Hou, Cai-Mei Zheng, Chien-Lin Lu, Wen-Chih Liu, Chia-Chao Wu, Ming-Te Huang, Yuh-Feng Lin, Kuo-Cheng Lu
BACKGROUND: Active Vitamin D analogues are used clinically for prevention and treatment of secondary hyperparathyroidism (SHPT) in hemodialysis (HD) patients. Nutritional vitamin D supplementation is used for additional local parathyroid (PTH) suppression, with lower incidence of hypercalcemia and hyperphosphatemia. This study evaluates the possible beneficial effects of combined vitamin D treatment (paricalcitol and cholecalciferol). METHODS: Sixty HD patients with serum parathyroid hormone (iPTH) >300 pg/mL were enrolled...
November 5, 2016: Nutrients
https://www.readbyqxmd.com/read/27771329/tln-58-an-additional-hcap18-processing-form-found-in-the-lesion-vesicle-of-palmoplantar-pustulosis-in-the-skin
#7
Masamoto Murakami, Kenji Kameda, Hiroki Tsumoto, Teruko Tsuda, Kana Masuda, Ryo Utsunomiya, Hideki Mori, Yuri Miura, Koji Sayama
We previously reported that the early vesicle of the palmoplantar pustulosis (PPP) vesicle originated from eccrine sweat in the acrosyringium and that the PPP vesicle contains the antimicrobial peptide human cathelicidin-18/LL-37. The concentration of LL-37 was sufficient to induce the subsequent inflammation in lesions and human keratinocytes, and the PPP vesicles contained additional small fragments of human cathelicidin-18, of approximately 7 kDa, which have not been identified. The aim of the present study was to clarify the additional processed forms found in PPP vesicles and their physiological effects on normal keratinocytes and sweat gland cells...
October 19, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27770941/bioactivity-characterization-of-45s5-bioglass-using-tl-osl-and-epr-comparison-with-the-case-of-58s-sol-gel-bioactive-glass
#8
G S Polymeris, V Giannoulatou, A Kyriakidou, I K Sfampa, G S Theodorou, E Şahiner, N Meriç, G Kitis, K M Paraskevopoulos
The current work exploits the effective application of thermoluminescence (TL), optically stimulated luminescence (OSL) and the possibility of applying Electron Paramagnetic Resonance (EPR) for the discrimination between different bioactive responses in the case of the 45S5 bioactive glass (SiO2 45, Na2O 24.5, CaO 24.5, P2O5 6 in wt%), which was synthesized through melting process. These techniques are suggested mainly due to their low spectroscopic detection thresholds. The original 45S5 in grain size range of 20-40μm was immersed in the Simulated Body Fluid (SBF) for various different immersion times ranging over one week...
January 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27722084/shortness-of-breath-patient-history-not-always-indicative-of-the-cause
#9
Tony S Brar, Neeka Akhavan
This is a 78 year old male with a past medical history of coronary artery disease (CAD), chronic obstructive pulmonary disease (COPD), hypertension (HTN), and gastroesophageal reflux disorder (GERD) who presented to the emergency room with worsening shortness of breath (SOB) and low-grade fevers for one week prior to admission. He was originally diagnosed with healthcare associated pneumonia (HCAP) and an acute on chronic COPD exacerbation and treated with prednisone, inhalers, ipratropium/albuterol, and broad-spectrum antibiotics...
2016: Respiratory Medicine Case Reports
https://www.readbyqxmd.com/read/27623169/serum-procalcitonin-an-independent-predictor-of-clinical-outcome-in-health-care-associated-pneumonia
#10
Dae Young Hong, Sang O Park, Jong Won Kim, Kyeong Ryong Lee, Kwang Je Baek, Ji Ung Na, Pil Cho Choi, Young Hwan Lee
BACKGROUND: Early prediction of the clinical outcomes for health care-associated pneumonia (HCAP) patients is challenging. OBJECTIVES: This is the first study to evaluate procalcitonin (PCT) as a predictor of outcomes in HCAP patients. METHODS: We conducted an observational study based on data for HCAP patients prospectively collected between 2011 and 2014. Outcome variables were intensive care unit (ICU) admission and 30-day mortality. PCT was categorized into three groups: <0...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27608182/the-use-of-ertapenem-for-the-treatment-of-community-acquired-pneumonia-in-routine-hospital-practice-a-matched-cohort-study
#11
D Sousa, J M Bravo-Ferrer, T Seoane-Pillado, P Vázquez-Rodríguez, L Ramos-Merino, J M Gutiérrez-Urbón, S Pita, P Llinares
OBJECTIVE: The clinical response to ertapenem in community-acquired pneumonia (CAP) at the setting of routine hospital practice has been scarcely evaluated. METHODS: We retrospectively compared CAP cases treated with ertapenem or with other standard antimicrobials (controls) at a tertiary 1,434-bed center from 2005 to 2014. RESULTS: Out of 6,145 patients hospitalized with CAP, 64 (1%) ertapenem-treated and 128 controls were studied (PSI IV-V 72%, mean age 73 years...
October 2016: Revista Española de Quimioterapia: Publicación Oficial de la Sociedad Española de Quimioterapia
https://www.readbyqxmd.com/read/27595461/health-care-associated-pneumonia-in-the-intensive-care-unit-guideline-concordant-antibiotics-and-outcomes
#12
Russell T Attridge, Christopher R Frei, Mary Jo V Pugh, Kenneth A Lawson, Laurajo Ryan, Antonio Anzueto, Mark L Metersky, Marcos I Restrepo, Eric M Mortensen
PURPOSE: Recent data have not demonstrated improved outcomes when guideline-concordant (GC) antibiotics are given to patients with health care-associated pneumonia (HCAP). This study was designed to evaluate the relationship between health outcomes and GC therapy in patients admitted to an intensive care unit (ICU) with HCAP. MATERIALS AND METHODS: We performed a population-based cohort study of patients admitted to greater than 150 hospitals in the US Veterans Health Administration system to compare baseline characteristics, bacterial pathogens, and health outcomes in ICU patients with HCAP receiving GC-HCAP therapy, GC community-acquired pneumonia (GC-CAP) therapy, or non-GC therapy...
December 2016: Journal of Critical Care
https://www.readbyqxmd.com/read/27529866/cinobufagin-modulates-human-innate-immune-responses-and-triggers-antibacterial-activity
#13
Shanshan Xie, Laura Spelmink, Mario Codemo, Karthik Subramanian, Katrin Pütsep, Birgitta Henriques-Normark, Marie Olliver
The traditional Chinese medicine Chan-Su is widely used for treatment of cancer and cardiovascular diseases, but also as a remedy for infections such as furunculosis, tonsillitis and acute pharyngitis. The clinical use of Chan-Su suggests that it has anti-infective effects, however, the mechanism of action is incompletely understood. In particular, the effect on the human immune system is poorly defined. Here, we describe previously unrecognized immunomodulatory activities of cinobufagin (CBG), a major bioactive component of Chan-Su...
2016: PloS One
https://www.readbyqxmd.com/read/27527659/total-duration-of-antimicrobial-therapy-in-veterans-hospitalized-with-uncomplicated-pneumonia-results-of-a-national-medication-utilization-evaluation
#14
REVIEW
Karl J Madaras-Kelly, Muriel Burk, Christina Caplinger, Jefferson G Bohan, Melinda M Neuhauser, Matthew Bidwell Goetz, Rongping Zhang, Francesca E Cunningham
OBJECTIVE: Practice guidelines recommend the shortest duration of antimicrobial therapy appropriate to treat uncomplicated pneumonia be prescribed to reduce the emergence of resistant pathogens. A national evaluation was conducted to assess the duration of therapy for pneumonia. DESIGN: Retrospective medication utilization evaluation. SETTING: Thirty Veterans Affairs medical centers. PATIENTS: Inpatients discharged with a diagnosis of pneumonia...
December 2016: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/27502599/risk-factors-to-predict-drug-resistant-pathogens-in-hemodialysis-associated-pneumonia
#15
Ping-Huai Wang, Hao-Chien Wang
BACKGROUND: After the concept of healthcare associated pneumonia (HCAP) was introduced in 2005 by the American Thoracic Society/Infectious Disease Society of America (ATS/IDSA), pneumonia in hemodialysis patients has been classified as HCAP. Even though there are several risk factors and scoring systems of drug-resistant pathogens (DRPs) in HCAP, the risk factors for DRPs in hemodialysis-associated pneumonia are unclear. METHODS: Patients who were admitted to our tertiary care hospital from January 2005 to December 2010 were screened by a discharge diagnosis of pneumonia...
2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27488327/a-randomized-controlled-trial-on-the-effect-of-vitamin-d3-on-inflammation-and-cathelicidin-gene-expression-in-ulcerative-colitis-patients
#16
Amrollah Sharifi, Mohammad Javad Hosseinzadeh-Attar, Homayoon Vahedi, Saharnaz Nedjat
BACKGROUND: Inflammatory bowel disease (IBD) is an intestinal chronic inflammatory condition and includes Crohn's disease (CD) and ulcerative colitis (UC). It has been proposed that Vitamin D supplementation may have a beneficial role in IBD. AIM: To characterize the effects of Vitamin D on cathelicidin (hCAP/LL37) gene expression, ESR, and serum hs-CRP levels. MATERIALS AND METHODS: Ninety UC patients on remission were randomized to receive 300,000 IU intramuscular Vitamin D or 1 mL normal saline as placebo, respectively...
July 2016: Saudi Journal of Gastroenterology: Official Journal of the Saudi Gastroenterology Association
https://www.readbyqxmd.com/read/27357804/vitamin-d-induced-up-regulation-of-human-keratinocyte-cathelicidin-anti-microbial-peptide-expression-involves-retinoid-x-receptor-%C3%AE
#17
Daniel Svensson, Daniel Nebel, Ulrikke Voss, Eva Ekblad, Bengt-Olof Nilsson
The biologically active form of vitamin D, 1α,25-dihydroxyvitamin D3 (1,25D3), has been reported to positively regulate the human cathelicidin anti-microbial peptide (CAMP) gene coding for LL-37, but the mechanisms are not completely understood. We have determined the expression of CAMP, vitamin D receptor (VDR), and the retinoid X receptor (RXR) isoforms in human skin and gingival tissue biopsies and investigated the signaling pathways involved in 1,25D3-induced upregulation of CAMP. Human skin and gingival biopsies exhibited few VDR-immunoreactive cells within the stratum basale, whereas rat colon enterocytes (positive control) possessed abundant VDR immunoreactivity...
June 30, 2016: Cell and Tissue Research
https://www.readbyqxmd.com/read/27356607/vitamin-d3-analog-maxacalcitol-oct-induces-hcap-18-ll-37-production-in-human-oral-epithelial-cells
#18
Hiroyuki Tada, Takamitsu Shimizu, Isao Nagaoka, Haruhiko Takada
Maxacalcitol (22-oxacalcitriol: OCT) is a synthetic vitamin D3 analog with a limited calcemic effect. In this study, we investigated whether OCT increases the production of LL-37/CAP-18, a human cathelicidin antimicrobial peptide, in human gingival/oral epithelial cells. A human gingival epithelial cell line (Ca9-22) and human oral epithelial cell lines (HSC-2, HSC-3, and HSC-4) exhibited the enhanced expression of LL-37 mRNA upon stimulation with OCT as well as active metabolites of vitamins D3 and D2. Among the human epithelial cell lines, Ca9-22 exhibited the strongest response to these vitamin D-related compounds...
2016: Biomedical Research
https://www.readbyqxmd.com/read/27346336/common-laboratory-parameters-for-differentiating-between-community-acquired-and-healthcare-associated-pneumonia
#19
Raymond Farah, Jonathan Bleier, Peter Gilbey, Rola Khamisy-Farah
BACKGROUND AND OBJECTIVES: The correct diagnosis of healthcare-associated pneumonia (HCAP) as opposed to community-acquired pneumonia is essential for the selection of a correct empirical antimicrobial approach, reserving the broad-spectrum or highly potent antimicrobial therapies for resistant strains most commonly present in HCAP, whereas treating the less resistant strains, most commonly associated with community and long-term care facility-acquired infections, with a more targeted empirical approach...
June 27, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27330964/association-of-influenza-with-severe-pneumonia-empyema-in-the-community-hospital-and-healthcare-associated-setting
#20
Masafumi Seki, Ryota Fuke, Nozomi Oikawa, Maya Hariu, Yuji Watanabe
UNLABELLED: We presented three cases of influenza-related severe pneumonia/empyema that occurred in one season. CASE 1: A 76-year-old diabetic man, developed empyema as a result of severe community-acquired pneumonia (CAP) secondary to Haemophilus influenzae, as confirmed on sputum culture. Nasal swab was positive for influenza A antigen. After drainage of empyema, intravenous peramivir and piperacillin/tazobactam were administered for 3 days and 2 weeks, respectively, followed by oral levofloxacin for 2 weeks...
2016: Respiratory Medicine Case Reports
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