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https://www.readbyqxmd.com/read/27753830/sy-03-3-overview-of-somatic-mutations-and-epigenetic-regulation-of-aldosterone-producing-adenoma-apa
#1
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27650288/reporting-and-dealing-with-missing-quality-of-life-data-in-rcts-has-the-picture-changed-in-the-last-decade
#2
REVIEW
S Fielding, A Ogbuagu, S Sivasubramaniam, G MacLennan, C R Ramsay
PURPOSE: Missing data are a major problem in the analysis of data from randomised trials affecting power and potentially producing biased treatment effects. Specifically focussing on quality of life outcomes, we aimed to report the amount of missing data, whether imputation was used and what methods and was the missing mechanism discussed from four leading medical journals and compare the picture to our previous review nearly a decade ago. METHODS: A random selection (50 %) of all RCTS published during 2013-2014 in BMJ, JAMA, Lancet and NEJM was obtained...
December 2016: Quality of Life Research
https://www.readbyqxmd.com/read/27642883/sy-03-3-overview-of-somatic-mutations-and-epigenetic-regulation-of-aldosterone-producing-adenoma-apa
#3
Satoshi Umemura
Primary aldosteronism (PA) is a heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most frequent endocrine cause of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension.Here I review the recent progress in understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.Systematic screening detects primary aldosteronism in 5 to 10% of all patients with hypertension and in approximately 20% of patients with resistant hypertension...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/26886545/a-randomized-controlled-trial-of-total-knee-replacement
#4
(no author information available yet)
No abstract text is available yet for this article.
February 18, 2016: New England Journal of Medicine
https://www.readbyqxmd.com/read/25539445/ebola-in-west-africa-at-one-year-from-ignorance-to-fear-to-roadblocks
#5
EDITORIAL
Jeffrey M Drazen, Edward W Campion, Eric J Rubin, Stephen Morrissey, Lindsey R Baden
It has been a year since the first case associated with the current Ebola virus outbreak in West Africa was identified and just over 8 months since we first started reporting on the outbreaks that stemmed from that patient in Guinea. Today's posts at NEJM.org include an anniversary update on the..
February 5, 2015: New England Journal of Medicine
https://www.readbyqxmd.com/read/24553518/haff-disease-associated-with-the-ingestion-of-the-freshwater-fish-mylossoma-duriventre-pacu-manteiga
#6
Oswaldo Tolesani Júnior, Christian Nejm Roderjan, Edgard do Carmo Neto, Micheli Mikaeli Ponte, Mariana Cristina Pelli Seabra, Marcos Freitas Knibel
Haff disease associated rhabdomyolysis is correlated with the ingestion of certain freshwater fish and shellfish and is caused by an unidentified toxin. We report the case of a patient who experienced rhabdomyolysis approximately 2 hours after ingestion of the freshwater fish Mylossoma duriventre (pacu-manteiga) approximately 3 years after an outbreak had been reported in Manaus, Brazilian Amazon.
October 2013: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/19437402/early-repolarization-electrocardiography-pattern-with-unexplained-syncope-during-training-in-a-young-black-african-non-elite-athlete-an-accidental-finding
#7
Aimé Bonny, Ivo Ditah, Walid Amara, Brahim Hamdaoui, Robert Frank, Jean-Yves Le Heuzey
Until recently it was generally thought that early repolarization is benign. But a recent article in the NEJM (Haissaguerre et al.) suggests that some persons with early repolarization may be at risk of life-threatening ventricular tachyarrhythmia. Unexplained syncope or sudden death occurs mostly during sleep. However, some cases of cardiac arrest during exertion have been reported. We report the case of a 39 year-old black African male with early repolarization pattern on electrocardiogram who regularly experienced dizziness (and one episode of transient loss of consciousness) exclusively while exercising...
2009: Cardiology Journal
https://www.readbyqxmd.com/read/18366697/the-use-of-interim-data-and-data-monitoring-committee-recommendations-in-randomized-controlled-trial-reports-frequency-implications-and-potential-sources-of-bias
#8
REVIEW
Puvan Tharmanathan, Melanie Calvert, John Hampton, Nick Freemantle
BACKGROUND: Interim analysis of accumulating trial data is important to protect participant safety during randomized controlled trials (RCTs). Data Monitoring Committees (DMCs) often undertake such analyses, but their widening role may lead to extended use of interim analysis or recommendations that could potentially bias trial results. METHODS: Systematic search of eight major publications: Annals of Internal Medicine, BMJ, Circulation, CID, JAMA, JCO, Lancet and NEJM, including all randomised controlled trials (RCTs) between June 2000 and May 2005 to identify RCTs that reported use of interim analysis, with or without DMC involvement...
2008: BMC Medical Research Methodology
https://www.readbyqxmd.com/read/17458396/a-descriptive-analysis-of-authorship-within-medical-journals-1995-2005
#9
Marc E Levsky, Alex Rosin, Troy P Coon, William L Enslow, Michael A Miller
INTRODUCTION: The emphasis on publications for promotion in academic medicine would lead one to the theory that authorship numbers would increase proportionally with this emphasis. To investigate authorship trends across a number of periodicals, we performed a descriptive study comparing two full years of published articles spaced ten years apart from five medical journals. METHODS: Physician reviewers each reviewed all articles of one medical journal for the 1995 and 2005 publication years...
April 2007: Southern Medical Journal
https://www.readbyqxmd.com/read/10227690/defective-glucose-transport-across-brain-tissue-barriers-a-newly-recognized-neurological-syndrome
#10
J Klepper, D Wang, J Fischbarg, J C Vera, I T Jarjour, K R O'Driscoll, D C De Vivo
Impaired glucose transport across brain tissue barriers causes infantile seizures, developmental delay and acquired microcephaly. Since the first report in 1991 (De Vivo et al, NEJM, 1991) 17 patients have been identified with the glucose transporter protein syndrome (GTPS). The diagnostic feature of the syndrome is an unexplained hypoglycorrhachia in the clinical setting of an infantile epileptic encephalopathy. We review our clinical experience by highlighting one illustrative case: a 6-year old girl who presented at age 2 months with infantile seizures and hypoglycorrhachia...
April 1999: Neurochemical Research
https://www.readbyqxmd.com/read/8591149/associating-semantic-grammars-with-the-snomed-processing-medical-language-and-representing-clinical-facts-into-a-language-independent-frame
#11
B Do Amaral Marcio, Y Satomura
We describe one approach for natural language processing of medical texts that associates a semantic grammar with the SNOMED (Systematized Nomenclature of Medicine). Our research hypothesis is that the combination of the nomenclature's declarative knowledge with a formal grammar would create a scientific sublanguage embedded with medical knowledge that could be used for analyzing and formatting medical texts. This combination permitted the abstraction of templates we call "semantic patterns." These patterns represent both linguistic and medical knowledge, packed into a hybrid information format...
1995: Medinfo
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